mfukuba/published_papers/54076538 西田 真理 大塚 邦紘 福場 真美 浪花 耕平 可児 耕一 桃田 幸弘 石丸 直澄 青田 桂子 老化関連B細胞を介したシェーグレン症候群の病態形成機序の解明 (NPO)日本口腔科学会 日本口腔科学会雑誌 2185-0461 73 2 146 146 20240900 mfukuba/published_papers/42745383 Mami Sato-Fukuba Rieko Arakaki Aya Ushio Kunihiro Otsuka Ruka Nagao Shigefumi Matsuzawa Hiroaki Tawara Takaaki Tsunematsu Naozumi Ishimaru CD4+ T-cell-dependent differentiation of CD23+ follicular B cells contributes to the pulmonary pathology in a primary Sjögren's syndrome mouse model Introduction Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease that affects the function of exocrine glands, such as the lacrimal and the salivary glands. Extraglandular lesions and malignant lymphoma also occur during the progressive stage of pSS. We have, herein, focused on the pulmonary lesions of pSS and have aimed clarifying their pathophysiological mechanism by comparing the glandular with the extraglandular lesions observed in a mouse model of pSS. Results The histopathological analysis of lung tissues obtained from NFS/sld mice that have undergone neonatal thymectomy was performed. Moreover, in vivo and in vitro experiments were conducted along with immunological analyses in order to characterize the unique phenotypes of the pulmonary lesions identified in these pSS model mice. Inflammatory lesions with a bronchus-associated lymphoid tissue-like structure were identified in the lungs of pSS model mice. In addition, relative to salivary gland lesions, pulmonary lesions showed increased CD23⁺ follicular B (FB) cells. In vitro and pulmonary B cells were more readily driven to CD23⁺ FB cell phenotype than salivary gland B cells in pSS model mice. Furthermore, the CD23⁺ FB cell differentiation was found to be enhanced in a CD4⁺ T-cell-dependent manner under a Th2-type condition in the lungs of herein examined pSS model mice. Discussion A Th2-type response in the pSS lung may promote the progression of autoimmune lesions through an enhanced abnormal differentiation of B cells. Frontiers Media SA Frontiers in Immunology 1664-3224 14 null null 20230705 10.3389/fimmu.2023.1217492 mfukuba/published_papers/42118040 Takaaki Tsunematsu Rieko Arakaki Mami Sato Masako Saito Kunihiro Otsuka Yusuke Furukawa Yuhji Taquahashi Jun Kanno Naozumi Ishimaru Exposure to Multiwall Carbon Nanotubes Promotes Fibrous Proliferation by Production of Matrix Metalloproteinase-12 via NF-κB Activation in Chronic Peritonitis. The American journal of pathology 1525-2191 192 11 null null 20220810 10.1016/j.ajpath.2022.07.009 35963465 2-s2.0-85141886100 mfukuba/published_papers/42118041 Kunihiro Otsuka Mami Sato Takaaki Tsunematsu Naozumi Ishimaru Virus Infections Play Crucial Roles in the Pathogenesis of Sjögren's Syndrome. Viruses 1999-4915 14 7 null null 20220704 10.3390/v14071474 35891453 2-s2.0-85133687255 mfukuba/published_papers/42118039 Mami Sato Rieko Arakaki Hiroaki Tawara Ruka Nagao Hidetaka Tanaka Kai Tamura Yuhki Kawahito Kunihiro Otsuka Aya Ushio Takaaki Tsunematsu Naozumi Ishimaru Disturbed natural killer cell homeostasis in the salivary gland enhances autoimmune pathology via IFN-γ in a mouse model of primary Sjögren's syndrome. Frontiers in medicine 2296-858X 9 1036787 1036787 20220000 10.3389/fmed.2022.1036787 36388880 2-s2.0-85141621873 mfukuba/published_papers/42118042 Mami Sato Rieko Arakaki Hiroaki Tawara Takaaki Tsunematsu Naozumi Ishimaru Formation of Autoimmune Lesions Is Independent of Antibiotic Treatment in NOD Mice. International journal of molecular sciences 1422-0067 22 6 null null 20210322 10.3390/ijms22063239 33810172 2-s2.0-85102763522 mfukuba/published_papers/42118043 Kunihiro Otsuka Akiko Yamada Masako Saito Aya Ushio Mami Sato Satoru Kisoda Wenhua Shao Takaaki Tsunematsu Yasusei Kudo Rieko Arakaki Naozumi Ishimaru Achaete-Scute Homologue 2-Regulated Follicular Helper T Cells Promote Autoimmunity in a Murine Model for Sjögren Syndrome. The American journal of pathology 1525-2191 189 12 2414 2427 20191200 10.1016/j.ajpath.2019.08.008 31539517 2-s2.0-85075213858 mfukuba/published_papers/42118044 Rieko Arakaki Aya Ushio Satoru Kisoda Mami Sato Yoshitaka Nakamura Kanako Yuyama Riho Tateyama Satoru Morishita Noriyuki Monoi Yasusei Kudo Naozumi Ishimaru Novel effects of rooibos extract on tear and saliva secretion mediated by the muscarinic acetylcholine receptor 3 in mice. Journal of oral biosciences 1349-0079 61 3 179 182 20190900 10.1016/j.job.2019.06.001 31400544 2-s2.0-85070548928 徳島大学口腔科学研究科優秀論文賞 20230300 第64回歯科基礎医学会学術大会 モリタ優秀発表賞 20220900 四国免疫フォーラム奨励賞 20210600 令和2年度口腔科学教育部研究奨励賞ゴールド賞 20200700