=== Generating (published_papers) === === Generating (teaching_experience) === === Generating (education) === === Generating (research_experience) === === Generating (awards) === === Generating (association_memberships) === === Generating (presentations) === ==== begin registerFile(/WWW/pub2/data/ERD/person/405953/researchmap/published_papers-propagate.jsonl) ==== line:1, {"insert":{"user_id":"R000099366","type":"published_papers","id":"51987618"},"force":{"see_also":[{"@id":"https://tokushima-u.repo.nii.ac.jp/records/2012829","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=412333","label":"url"}],"paper_title":{"en":"Serum-Derived Macrophage-Activating Factor ExhibitsAnti-Tumor Activity via M2-to-M1 Macrophage Reprogramming","ja":"Serum-Derived Macrophage-Activating Factor ExhibitsAnti-Tumor Activity via M2-to-M1 Macrophage Reprogramming"},"authors":{"en":[{"name":"Takara Tsuyoshi"},{"name":"Takara Rei"},{"name":"Kobayashi Aya"},{"name":"Shirakata Hina"},{"name":"Ambai Shinobu"},{"name":"Shinohara Yusei"},{"name":"Uto Yoshihiro"}],"ja":[{"name":"髙良 毅"},{"name":"髙良 玲衣"},{"name":"小林 彩"},{"name":"白形 妃菜"},{"name":"Ambai Shinobu"},{"name":"篠原 侑成"},{"name":"宇都 義浩"}]},"publication_date":"2024-06","publication_name":{"en":"International Journal of Translational Medicine","ja":"International Journal of Translational Medicine"},"volume":"4","starting_page":"439","ending_page":"449","languages":["eng"],"referee":true,"identifiers":{"doi":["10.3390/ijtm4030029"],"issn":["2673-8937"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} line:2, {"insert":{"user_id":"R000099366","type":"published_papers","id":"51987619"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/38246115","label":"url"},{"@id":"https://www.scopus.com/pages/publications/85183558460","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=412332","label":"url"}],"paper_title":{"en":"Development of UTX-143, a Selective Sodium-hydrogen Exchange Subtype 5 Inhibitor, using Amiloride as a Lead Compound","ja":"Development of UTX-143, a Selective Sodium-hydrogen Exchange Subtype 5 Inhibitor, using Amiloride as a Lead Compound"},"authors":{"en":[{"name":"Shinohara Yusei"},{"name":"Komiya Yuki"},{"name":"morimoto Kashin"},{"name":"Endo Yoshio"},{"name":"Terashima Minoru"},{"name":"Suzuki Takeshi"},{"name":"Takino Takahisa"},{"name":"Ninomiya Itasu"},{"name":"Yamada Hisatsugu"},{"name":"Uto Yoshihiro"}],"ja":[{"name":"篠原 侑成"},{"name":"小宮 悠生"},{"name":"森本 華真"},{"name":"遠藤 良夫"},{"name":"Terashima Minoru"},{"name":"Suzuki Takeshi"},{"name":"Takino Takahisa"},{"name":"Ninomiya Itasu"},{"name":"山田 久嗣"},{"name":"宇都 義浩"}]},"description":{"en":"NHE5, an isoform of the Na/H exchanger (NHE) protein, is an ion-transporting membrane protein that regulates intracellular pH and is highly expressed in colorectal adenocarcinoma. Therefore, we hypothesized that NHE5 inhibitors can be used as anticancer drugs. However, because NHE1 is ubiquitously expressed in all cells, it is extremely important to demonstrate its selective inhibitory activity against NHE5. We used amiloride, an NHE non-selective inhibitor, as a lead compound and created UTX-143, which has NHE5-selective inhibitory activity, using a structure-activity relationship approach. UTX-143 showed selective cytotoxic effects on cancer cells and reduced the migratory and invasive abilities of cancer cells. These results suggest a new concept wherein drugs exhibit cancer-specific cytotoxic effects through selective inhibition of NHE5 and the possibility of UTX-143 as a lead NHE5-selective inhibitor.","ja":"NHE5, an isoform of the Na/H exchanger (NHE) protein, is an ion-transporting membrane protein that regulates intracellular pH and is highly expressed in colorectal adenocarcinoma. Therefore, we hypothesized that NHE5 inhibitors can be used as anticancer drugs. However, because NHE1 is ubiquitously expressed in all cells, it is extremely important to demonstrate its selective inhibitory activity against NHE5. We used amiloride, an NHE non-selective inhibitor, as a lead compound and created UTX-143, which has NHE5-selective inhibitory activity, using a structure-activity relationship approach. UTX-143 showed selective cytotoxic effects on cancer cells and reduced the migratory and invasive abilities of cancer cells. These results suggest a new concept wherein drugs exhibit cancer-specific cytotoxic effects through selective inhibition of NHE5 and the possibility of UTX-143 as a lead NHE5-selective inhibitor."},"publication_date":"2024-01-14","publication_name":{"en":"Bioorganic & Medicinal Chemistry","ja":"Bioorganic & Medicinal Chemistry"},"volume":"99","starting_page":"117603","ending_page":"117603","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.bmc.2024.117603"],"issn":["1464-3391"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} line:3, {"insert":{"user_id":"R000099366","type":"published_papers","id":"51987620"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=412331","label":"url"}],"paper_title":{"en":"Enhancing Effect of Novel Schiff Base Derivatives, UTX-134 and UTX-135, on 5-Aminolevulinic Acid-based Photodynamic Therapy","ja":"Enhancing Effect of Novel Schiff Base Derivatives, UTX-134 and UTX-135, on 5-Aminolevulinic Acid-based Photodynamic Therapy"},"authors":{"en":[{"name":"Yamahana Hirari"},{"name":"Shinohara Yusei"},{"name":"Endo Yoshio"},{"name":"Obata Tohru"},{"name":"Yamada Hisatsugu"},{"name":"Uto Yoshihiro"}],"ja":[{"name":"山花 啓梨"},{"name":"篠原 侑成"},{"name":"遠藤 良夫"},{"name":"Obata Tohru"},{"name":"山田 久嗣"},{"name":"宇都 義浩"}]},"publication_date":"2021-08","publication_name":{"en":"ALA-Porphyrin Science","ja":"ALA-Porphyrin Science"},"volume":"10","number":"1","starting_page":"1","ending_page":"14","languages":["eng"],"referee":true,"published_paper_type":"scientific_journal"},"priority":"input_data"} ==== end registerFile(/WWW/pub2/data/ERD/person/405953/researchmap/published_papers-propagate.jsonl, 5iZF-J8Bn_HdSsNVDFYM) ==== ====== BulkResult(R000099366, 5iZF-J8Bn_HdSsNVDFYM) : Begin ====== --- error {"code":304,"status":"completion","start_datetime":"2026-08-13T00:37:21Z","end_datetime":"2026-08-13T00:37:21Z","estimated_end_datetime":"2026-08-13T00:37:22Z","total_items":3} --- success {"code":304,"status":"completion","start_datetime":"2026-08-13T00:37:21Z","end_datetime":"2026-08-13T00:37:21Z","estimated_end_datetime":"2026-08-13T00:37:22Z","total_items":3} {"no":1,"line":1,"code":304,"action":"insert","action_type":"merge","type":"published_papers","id":"51987618","link":"https://api.researchmap.jp/Yusei_Shinohara/published_papers/51987618","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =51987618]。"}]} {"no":1,"line":2,"code":304,"action":"insert","action_type":"merge","type":"published_papers","id":"51987619","link":"https://api.researchmap.jp/Yusei_Shinohara/published_papers/51987619","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =51987619]。"}]} {"no":1,"line":3,"code":304,"action":"insert","action_type":"merge","type":"published_papers","id":"51987620","link":"https://api.researchmap.jp/Yusei_Shinohara/published_papers/51987620","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =51987620]。"}]} ====== BulkResult(R000099366, 5iZF-J8Bn_HdSsNVDFYM) : End ======