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en: Synthesis and Application of Immunomodulatory Natural Products

ja: 天然化合物を基盤とした免疫調節性分子の合成と展開

en: Journal of Synthetic Organic Chemistry, Japan

ja: 有機合成化学協会誌


en: Chemical Synthesis and Molecular Interaction Analysis of α-Galactosyl Ceramide Derivatives as CD1d Ligands.

en: CD1d is a non-classical major histocompatibility complex (MHC) protein, responsible for lipid antigen presentation, which presents lipids to natural killer T (NKT) cells. Various CD1d lipid ligands have been reported, including microbial and endogenous glycolipids/phospholipids. Among them, an α-galactosylceramide (α-GalCer), a representative CD1d ligand, is one of the most potent ligands and its derivatives have been developed. In this chapter, the chemistry of α-GalCer and its derivatives are described with an emphasis on their chemical syntheses and molecular interaction analysis with CD1d are described.

en: Methods in Molecular Biology

ja: Methods in Molecular Biology


en: 脂質改変型CD1dリガンドの創製

ja: 脂質改変型CD1dリガンドの創製

en: 月刊ファインケミカル

ja: 月刊ファインケミカル


en: Azido-Alkynes in Gold(I)-Catalyzed Indole Syntheses.

en: The exploitation of nitrogen-functionalized reactive intermediates plays an important role in the synthesis of biologically relevant scaffolds in the field of pharmaceutical sciences. Those based on gold carbenes carry a strong potential for the design of highly efficient cascade processes toward the synthesis of compounds containing a fused indole core structure. This personal account gives a detailed explanation of our contribution to this sector, and embraces the reaction development of efficient gold-catalyzed cascade processes based on diversely functionalized azido-alkynes. Challenging cyclizations and their subsequent application in the synthesis of pharmaceutically relevant scaffolds and natural products conducted in an intra- or intermolecular fashion are key features of our research.

en: Chemical Record

ja: Chemical Record


en: Nonbiomimetic total synthesis of indole alkaloids using alkyne-based strategies.

en: Biomimetic natural product synthesis is generally straightforward and efficient because of its established feasibility in nature and utility in comprehensive synthesis, and the cost-effectiveness of naturally derived starting materials. On the other hand, nonbiomimetic strategies can be an important option in natural product synthesis since (1) nonbiomimetic synthesis offers more flexibility and can demonstrate the originality of chemists, and (2) the structures of derivatives accessible by nonbiomimetic synthesis can be considerably different from those that are synthesised in nature. This review summarises nonbiomimetic total syntheses of indole alkaloids using alkyne chemistry for constructing core structures, including ergot alkaloids, monoterpene indole alkaloids (mainly corynanthe, aspidosperma, strychnos, and akuammiline), and pyrroloindole and related alkaloids. To clarify the differences between alkyne-based strategies and biosynthesis, the alkynes in nature and the biosyntheses of indole alkaloids are also outlined.

en: Organic & Biomolecular Chemistry

ja: Organic & Biomolecular Chemistry


en: Total Syntheses of Myriocin, Mycestericins and Sphingofungin E: Sphingosine Analogues Containing a β, β¤-Dihydroxy α-Amino Acid Framework

en: Chemistry Letters

ja: Chemistry Letters


en: Total synthesis of naturally occurring chiral cyclopropane fatty acids and related compounds

en: Tetrahedron Letters

ja: Tetrahedron Letters


en: Development and functional evaluation of Th2-biased CD1d ligands containing modified lipid moiety

ja: Th2バイアス型脂質改変CD1dリガンド開発と機能解析

en: Endotoxin and Innate Immunity

ja: エンドトキシン・自然免疫研究


en: Recent Progress in Palladium-Catalyzed Cascade Cyclizations for Natural Product Synthesis

en: Synthesis

ja: Synthesis


en: 糖脂質 α-GalCer を基盤とした脂質改変型 CD1d リガンドの創製研究

ja: 糖脂質 α-GalCer を基盤とした脂質改変型 CD1d リガンドの創製研究

en: エンドトキシン・自然免疫研究20

ja: エンドトキシン・自然免疫研究20


en: Gold-Catalyzed Activation of Glycosyl Donors with Alkyne Moieties for Glycosylation Reaction

ja: Au触媒によるアルキンの活性化を鍵としたグリコシル化反応

en: Glycosylation reaction is an important class of reactions in organic chemistry, and the development of the method contributes to the synthesis of many biologically active compounds containing various glycoside bonds. Recently, several groups have developed novel glycosylation reactions using gold catalysis, which has unique reactivities, such as high`alkynophilicity'. In this short review, recent reports about gold-catalyzed glycosylation reactions through the activation of alkyne moieties are described.

en: Journal of Synthetic Organic Chemistry, Japan


en: The Synthesis of Alkaloids Using Transition-Metal-Catalyzed Intramolecular Amination Reactions

en: Synlett

ja: Synlett