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en: A Case of Nevoid Basal Cell Carcinoma Syndrome with an Odontogenic Keratocyst Removed by Endoscopic Endonasal Surgery

ja: 上顎骨歯原性角化囊胞を内視鏡下鼻内手術で摘出した母斑基底細胞癌症候群例

en: Practica Oto-Rhino-Laryngologica

ja: 耳鼻咽喉科臨床


en: A Pediatric Case of Earpick Injury Accompanied with Traumatic Facial Palsy and Ossicular Disruption Treated by Transcanal Endoscopic Ear Surgery

ja: 経外耳道的内視鏡下耳科手術を施行した耳小骨離断と顔面神経麻痺をきたした小児耳かき外傷例


en: A Case of Radiation-Induced Meningioma of the Cerebellopontine Angle in a Young Man Presenting with Disequilibrium

ja: ふらつき，浮動性めまいで発症した小児放射線誘発性髄膜腫例

en: Equilibrium Research

ja: Equilibrium Research


en: Orbital apex syndrome secondary to acute invasive fungal rhinosinusitis diagnosed by transnasal endoscopic biopsy of the optic canal:A case report.

en: Orbital apex syndrome (OAS) is a complex condition characterized by visual loss, diplopia, and eye pain that occurs secondary to several pathological processes involving the orbital apex. We report a case of acute invasive fungal rhinosinusitis (AIFRS) associated with OAS. A 76-year-old man with left-sided visual loss, diplopia, palpebral ptosis, and headache was diagnosed with OAS secondary to Tolosa-Hunt syndrome and received systemic corticosteroid therapy from his neurologist. Owing to persistent symptoms, we opened the optic canal using a transnasal endoscopic approach for a surgical biopsy of the orbital apex lesions. Histopathological evaluation revealed numerous Aspergillus organisms in the biopsied granuloma. After surgical debridement, he received a 12-month course of voriconazole, and no recurrence of AIFRS occurred during 8-year follow-up. Patients with OAS may occasionally be prescribed corticosteroids because the clinical manifestations of AIFRS-induced OAS are similar to those observed in OAS secondary to Tolosa-Hunt syndrome, especially no nasal symptoms which is known to respond to corticosteroid therapy. Because both AIFRS-induced OAS and OAS secondary to Tolosa-Hunt syndrome induce ophthalmoplegia, proptosis, eye pain, it is sometimes difficult to differentiate these two diseases in early stage. However, corticosteroid therapy causes exacerbation of fungal infection in patients with AIFRS-induced OAS resulting in delayed accurate diagnosis and poor prognosis. AIFRS is associated with a high mortality rate ; therefore, transnasal endoscopic biopsy of orbital apex lesions before corticosteroid administration is recommended in patients with OAS. J. Med. Invest. 71 : 310-313, August, 2024.

en: The Journal of Medical Investigation : JMI