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en: High Remission Rate in Eosinophilic Chronic Rhinosinusitis Following More Than Two Years of Dupilumab Therapy


en: TWO CASES OF MPO-ANCA-POSITIVE EGPA WITH CHRONIC RHINOSINUSITIS SHOWING DIFFERENT RESPONSES TO MEPOLIZUMAB

ja: MPO-ANCA陽性のEGPAに伴う鼻副鼻腔炎に対するメポリズマブの効果が異なった2症例

en: Japanese Journal of Allergology

ja: アレルギー


en: A Case of Nevoid Basal Cell Carcinoma Syndrome with an Odontogenic Keratocyst Removed by Endoscopic Endonasal Surgery

ja: 上顎骨歯原性角化囊胞を内視鏡下鼻内手術で摘出した母斑基底細胞癌症候群例

en: Practica Oto-Rhino-Laryngologica

ja: 耳鼻咽喉科臨床


ja: TWO CASES OF MPO-ANCA-POSITIVE EGPA WITH CHRONIC RHINOSINUSITIS SHOWING DIFFERENT RESPONSES TO MEPOLIZUMAB

en: Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic vasculitis associated with chronic rhinosinusitis (CRS) and bronchial asthma. Mepolizumab, an anti-IL-5 monoclonal antibody, has been used in the treatment of EGPA. We report two cases of MPO-ANCA-positive EGPA with CRS that exhibited differing responses to mepolizumab. In Case 1, nasal symptoms persisted despite mepolizumab treatment, and CRS recurred early after endoscopic sinus surgery (ESS). In contrast, Case 2 developed EGPA following dupilumab administration, but nasal symptoms improved with mepolizumab and remained well controlled. These cases suggest that the efficacy of mepolizumab for CRS in ANCA-positive EGPA varies among patients. Even in cases that respond well to treatment, recurrence may still occur, underscoring the importance of continuous follow-up in close collaboration with internal medicine specialists.