label: url

en: 手術療法が有効であった難治性絨毛癌の肺転移の一例

ja: 手術療法が有効であった難治性絨毛癌の肺転移の一例

en: 徳島産婦人科医報

ja: 徳島産婦人科医報


en: New treatment strategies for uterine sarcoma using secreted frizzledrelated proteins

en: Secreted frizzled-related proteins (SFRPs) are involved in the development of various types of cancer and function by suppressing the Wnt signaling pathway. To elucidate the clinical implications of SFRPs in uterine sarcoma, SFRP expression levels and their effects on uterine leiomyosarcoma cells were examined. Immunostaining for SFRP4 was performed on uterine smooth muscle, uterine fibroid and uterine leiomyosarcoma tissues. Additionally, the effects of SFRP4 administration on cell viability, migration and adhesion were evaluated in uterine leiomyosarcoma SKN cells using the WST-1 assay (Roche Diagnostics) and the CytoSelect 24-well Cell Migration Assay Kit and the CytoSelect 48-well Cell Adhesion Assay Kit. The expression levels of SFRP4 in uterine leiomyosarcoma tissues were lower than those in normal smooth muscle and uterine fibroid tissues. In addition, SFRP4 suppressed the viability and migration, and increased the adhesion ability of uterine leiomyosarcoma cells compared with in the control group. In conclusion, SFRP4 may suppress the viability and migration, and enhance the adhesion of sarcoma cells. These results suggested that SFRP4 could be considered as a novel therapeutic target for uterine sarcoma.

en: Experimental and Therapeutic Medicine

ja: Experimental and Therapeutic Medicine


en: 当院における最近の微弱陣痛の頻度とオキシトシン製剤投与時に配慮すべき母児への影響

en: Modern Trends in Obstetrics & Gynecology

ja: 現代産婦人科


en: 術前に卵巣原発胚細胞性腫瘍を疑ったが，傍卵巣の平滑筋肉腫であった一例

ja: 術前に卵巣原発胚細胞性腫瘍を疑ったが，傍卵巣の平滑筋肉腫であった一例