{"insert":{"user_id":"5000005612","type":"misc"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/21158720","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=251787","label":"url"}],"paper_title":{"en":"Silica Nanoparticles as Promising Drug/Gene Delivery Carriers and Fluorescent Nano-Probes: Recent Advances: Recent Advances","ja":"Silica Nanoparticles as Promising Drug/Gene Delivery Carriers and Fluorescent Nano-Probes: Recent Advances: Recent Advances"},"authors":{"en":[{"name":"Liu Y"},{"name":"Lou C"},{"name":"Yang H"},{"name":"Shi M"},{"name":"Miyoshi Hirokazu"}],"ja":[{"name":"Liu Y"},{"name":"Lou C"},{"name":"Yang H"},{"name":"Shi M"},{"name":"三好 弘一"}]},"description":{"en":"The application of nanotechnology to biomedical research is expected to have a major impact leading to the development of new types of diagnostic and therapeutic tools. One focus in nanobiotechnology is to develop safe and efficient drug/gene delivery vehicles. Research into the rational delivery and targeting of pharmaceutical, therapeutic and diagnostic agents is at the forefront of projects in nanomedicine. Silica, as a major and natural component of sand and glass, is a versatile material due to the variety of available chemical and physical modifications that are available, and recently have been widely applied in nanobiotechnology as drug/gene carriers or fluorescent nano-probes. The goal of this brief review is to illustrate selected examples of various functionalized silica nanoparticles as drug/gene delivery systems that have been applied to the arenas of human disease therapy or detection (molecular and cellular imaging).","ja":"The application of nanotechnology to biomedical research is expected to have a major impact leading to the development of new types of diagnostic and therapeutic tools. One focus in nanobiotechnology is to develop safe and efficient drug/gene delivery vehicles. Research into the rational delivery and targeting of pharmaceutical, therapeutic and diagnostic agents is at the forefront of projects in nanomedicine. Silica, as a major and natural component of sand and glass, is a versatile material due to the variety of available chemical and physical modifications that are available, and recently have been widely applied in nanobiotechnology as drug/gene carriers or fluorescent nano-probes. The goal of this brief review is to illustrate selected examples of various functionalized silica nanoparticles as drug/gene delivery systems that have been applied to the arenas of human disease therapy or detection (molecular and cellular imaging)."},"publication_date":"2011-02","publication_name":{"en":"Current Cancer Drug Targets","ja":"Current Cancer Drug Targets"},"volume":"11","number":"2","starting_page":"156","ending_page":"163","languages":["eng"],"identifiers":{"doi":["10.2174/156800911794328411"],"issn":["1568-0096"]},"misc_type":"introduction_scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"5000005612","type":"misc"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/16824637","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=164973","label":"url"}],"paper_title":{"en":"Encapsulated ultrasound microbubbles: Therapeutic application in drug/gene delivery","ja":"Encapsulated ultrasound microbubbles: Therapeutic application in drug/gene delivery"},"authors":{"en":[{"name":"Liu Yiyao"},{"name":"Miyoshi Hirokazu"},{"name":"Nakamura Michihiro"}],"ja":[{"name":"Liu Yiyao"},{"name":"三好 弘一"},{"name":"中村 教泰"}]},"description":{"en":"Encapsulated gas microbubbles are well known as ultrasound contrast agents for medical ultrasound imaging. Nonetheless, not only do these microbubbles help to image, but they can also be used as drug/gene carriers. The microbubbles as drug/gene carriers have an average size less than that of red blood cells, i.e. they are capable of penetrating even into the small blood capillaries and releasing drug and genes under the action of ultrasound field. The application of ultrasound and microbubbles to targeted drug and gene delivery has been the subject of intense experimental research. Under exposure of sufficiently high-amplitude ultrasound, these targeted microbubbles would rupture, spewing drugs or genes, which are contained in its encapsulating layer, to targeted cells or tissues. Recently, targeting ligands are attached to the surface of the microbubbles (i.e. targeted-microbubbles), which have been widely used in cardiovascular system and tumor diagnosis and therapy. In this paper, the characterization of novel targeted ultrasonic contrast agents or microbubbles and their potential applications in drug delivery or gene therapy are reviewed.","ja":"Encapsulated gas microbubbles are well known as ultrasound contrast agents for medical ultrasound imaging. Nonetheless, not only do these microbubbles help to image, but they can also be used as drug/gene carriers. The microbubbles as drug/gene carriers have an average size less than that of red blood cells, i.e. they are capable of penetrating even into the small blood capillaries and releasing drug and genes under the action of ultrasound field. The application of ultrasound and microbubbles to targeted drug and gene delivery has been the subject of intense experimental research. Under exposure of sufficiently high-amplitude ultrasound, these targeted microbubbles would rupture, spewing drugs or genes, which are contained in its encapsulating layer, to targeted cells or tissues. Recently, targeting ligands are attached to the surface of the microbubbles (i.e. targeted-microbubbles), which have been widely used in cardiovascular system and tumor diagnosis and therapy. In this paper, the characterization of novel targeted ultrasonic contrast agents or microbubbles and their potential applications in drug delivery or gene therapy are reviewed."},"publication_date":"2006-05-27","publication_name":{"en":"Journal of Controlled Release","ja":"Journal of Controlled Release"},"volume":"114","number":"1","starting_page":"89","ending_page":"99","languages":["eng"],"identifiers":{"doi":["10.1016/j.jconrel.2006.05.018"],"issn":["0168-3659"]},"misc_type":"introduction_scientific_journal"},"priority":"input_data"}
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