Expresson of Proliferating Cell Nuclear Antigen(PCNA) in biopsy and autopsy specimens of gastric carcinoma

Although proliferating cell nuclear antigen (PCNA) is known to be an indicator of malignant potential in tumors, the biological and clinicopathological significance of PCNA in tumor tissue is controversial. Immunohistochemical expression of PCNA was examined in 58 gastric carcinoma tissues obtained at autopsy to test the clinicopathological significance. In addition, in 24 of the 58 tumor tissues we compared immunohistochemical expression of PCNA in biopsy and autopsy specimens from the same patient in order to know whether the proliferating activity of tumor cells is stationary from the early stage to the end of tumor growth. 1. PCNA was undetectable in some tumor tissues (12.5% in biopsy and 10.3% in autopsy specimens). 2. the frequency of PCNA positive cases and labeling index (LI) (%) of PCNA in tumor tissues were not significantly different between biopsy and autopsy specimens. 3. the intensity of PCNA reaction was not related to prognosis. 4. PCNA positive cases and LI did not correlate with survival condition. It is hard to say whether PCNA is a reliable indicator in predicting malignancy and prognosis of gastric cancer.


Role of left atrial appendage in left atrial reservoir function as evaluated by left atrial appendage clamping during cardiac surgery.


Expression of type I and type III collagens during the course of dimethylnitrosamine-induced hepatic fibrosis in rats


Right atrial potential profiles during atrial fibrillation predict the success of atrial defibrillation

The right atrial electric potential was measured in 29 patients with chronic atrial fibrillation, and the clinical utility of these measurements in predicting the success of atrial defibrillation was investigated. The endocardial electric potential was recorded at 12 sites within the right atrium (high, middle, and low loci of anterior, posterior, lateral, and medial sites of the right atrium) with an electrode catheter. The duration and polar displacement of the atrial waves were measured at the one site that showed the maximum atrial electric potential among the 12 sites. The ratio of the maximum to the minimum atrial electric potential (atrial wave ratio) was calculated. Patients were classified into two groups according to the success (n = 6) or failure (n = 23) of atrial defibrillation. Electrophysiologic data were compared between the two groups, and correlations were evaluated between the data and the maximal left atrial diameter obtained from M-mode echocardiography. The two groups did not differ in the duration and polar displacement of the atrial waves. However, the atrial wave ratio was significantly lower in the success group than in the failure group, and the success rate of atrial defibrillation was also significantly greater in the patients with an atrial wave ratio of 10 or lower. This ratio showed a positive correlation with the maximal left atrial diameter; it became more difficult to achieve atrial defibrillation as the atrial wave ratio increased. Thus, the right atrial electric potential profile of patients with atrial fibrillation is a useful predictor of the success of atrial defibrillation.


Suppressive effect of estradiol on chemical hepatocarcinogenesis in rats.

To examine the effects of oestradiol and testosterone on the early carcinogenic changes expressed in rat liver from the diethylnitrosamine (DEN), 2-acetylaminofluorene (AAF), partial hepatectomy (PH) model of hepatocarcinogenesis. Preneoplastic liver lesions were evaluated using immunohistochemical analysis of glutathione-S-transferase placental form (GST-P) expression; oestrogen and androgen receptor levels were measured by radioimmunoassay. Oestradiol administration to non-castrated DEN-AAF-PH treated males resulted in a decrease in the area of GST-P positive foci, while testosterone increased the serum oestradiol level and reduced the area. In males, castration alone and castration with oestradiol replacement significantly reduced the GST-P positive area, and increased the hepatic oestrogen receptor level. In DEN-AAF-PH treated females, castration with testosterone replacement was associated with a significant increase in the GST-P positive area and the hepatic androgen receptor level. These findings suggest that exogenous and endogenous oestradiol can suppress chemical hepatocarcinogenesis. It appears that oestrogen receptors may be involved in the inhibition of malignant transformation of preneoplastic liver cells, while androgens and androgen receptors are involved in hepatocarcinogenesis.


Differences in transmitral flow velocity pattern during increase in preload in patients with abnormal left ventricular relaxation.

Changes in transmitral flow (TMF) and pulmonary venous flow (PVF) velocities during increases in preload were compared in patients with a higher peak atrial systolic velocity than peak early diastolic velocity (A/E > 1) for the TMF velocity to determine differences in hemodynamic response. Fifteen patients with dilated hearts, 22 with hypertrophied hearts and 15 control patients were studied. TMF and PVF velocities were recorded by transesophageal pulsed Doppler echocardiography before and during application of lower body positive pressure. The value for peak early diastolic velocity increased, while the isovolumic relaxation time decreased with increases in preload in all groups. The value for peak atrial systolic velocity decreased in the dilated-heart group, but increased in the hypertrophied-heart and control groups. The peak second systolic and early diastolic PVF velocities increased in the dilated- and hypertrophied-heart groups, but did not change in the control group. The peak atrial systolic PVF velocity and the difference in duration of the atrial systolic PVF and TMF velocities increased in the dilated- and hypertrophied-heart groups, and its changing rate was highest in the group with dilated hearts. These results suggest that both peak early diastolic and atrial systolic TMF velocities increase during increases in preload through the Frank-Starling mechanism in hypertrophied hearts. Furthermore, the left ventricular functional reserve was lower in the dilated-heart group. Thus, TMF and PVF velocities respond differently during increases in preload, depending on the underlying heart disease.


心磁界から求めた心室脱分極ベクトルの加齢変化

心磁界から求めた心室脱分極ベクトルの加齢変化

The Journal of Japan Biomagnetism and Bioelectromagnetics Society


The Official Journal of Japanese Society of Laboratory Medicine


Dihydropridine系Ca拮抗薬の心臓交感神経機能への影響

Dihydropridine系Ca拮抗薬の心臓交感神経機能への影響


Coronary-Pulmonary Artery Fistulae Depicted by Multiplanar Reconstruction Using Magnetic Resonance Imaging


Effects of intravenous administration of L-arginine on autonomic nervous activities: Analysis of heart rate variability


Synthesis and Reactivities of 3-Indocyanine-green-acyl-1,3-thiazolidine-2-thione (ICG-ATT) as a New Near-Infrared Fluorescent-labeling Reagent


Right atrial electric potential profiles in patients with atrial fibrillation predict the success of atrial defibrillation


Effects of quinaprilat on electrophysiologic changes during acute myocardial ischaemia and following reperfusion in canines


Ischaemic electrocardiographic changes after massive blood transfusion : Findings based on myocardial scintigraphy using 99mTc-MIBI and 123I-MIBG

We performed myocardial scintigraphy on a patient with ischaemic electrocardiographic changes after massive blood transfusion. Although there was no defect by 99mTc-MIBI scintigraphy, 123I-MIBG scintigraphy was observed suggesting denervation after massive blood transfusion. Myocardial scintigraphy using 99mTc-MIBI or 123I-MIBG can be useful for the evaluation of myocardial dysfunction with reversible myocardial infarction.


Evaluation of Left Atrial Filling Using Systolic Pulmonary Venous Flow Velocity Measurements in Patients with Atrial Fibrillation


Usefulness and Limitations of Endoscopic Ultrasonography in Diagnosis of Adenomyomatosis of the Gallbladder


Autonomic nervous system activity during infusion of L-arginine in patients with liver cirrhosis


Characteristics of Coronary Flow Velocity in Constrictive Pericarditis

Catheterization and Cardiovascular Diagnosis


Electrophysiologic effects of quinaprilat in dogs during acute myocardial ischemia and following reperfusion.

There have been few studies concerning the electrophysiologic changes associated with the use of angiotensin-converting enzyme inhibitors in patients with acute myocardial infarction. We examined the electrophysiologic effects of quinaprilat in dogs during acute myocardial ischemia and following reperfusion. The left anterior descending coronary artery was occluded for 10 min and reperfused for 10 min. Animals received intravenous quinaprilat (3 micrograms/kg per min, quinaprilat group) or saline (control group). We measured the ventricular effective refractory period and intra-myocardial conduction time within the left anterior descending coronary artery region (ischemic region) during myocardial ischemia and following reperfusion, and determined the frequency of ventricular fibrillation. The effective refractory period in the ischemic region decreased during myocardial ischemia and decreased further immediately after reperfusion in the control group. The intra-myocardial conduction time in the ischemic region increased during myocardial ischemia but rapidly shortened after reperfusion in the control group. In the quinaprilat group, however, no significant differences were evident between the ischemic and non-ischemic regions in either the effective refractory period or the intra-myocardial conduction time during myocardial ischemia or following reperfusion. The percentage shortening of the effective refractory period and the percentage prolongation of the intra-myocardial conduction time in the ischemic region were significantly lower in the quinaprilat group than in the control group during myocardial ischemia and following reperfusion. The frequency of ventricular fibrillation during myocardial ischemia and following reperfusion was significantly lower in the quinaprilat group (21%) than in the control group (74%; P < 0.01). Quinaprilat protects against electrophysiologic abnormalities, and may decrease arrhythmias during acute myocardial ischemia and following reperfusion.


Coronary flow velocity patterns immediately after reperfusion reflect pathologic characteristics of reperfused myocardium in canine models of acute myocardial infarction

It is difficult to evaluate the extent of myocardial injury after successful reperfusion following acute myocardial infarction (AMI). We investigated the relationship between the coronary flow velocity pattern immediately after reperfusion and pathologic characteristics after myocardial reperfusion injury in dogs. We measured distal coronary flow velocity variables in the left circumflex coronary artery in a canine model of AMI (n = 12) 10 min after the release of a clamp (3-10 h clamp procedure) using a 0.35 mm Doppler guide-wire. Dogs were divided into two groups according to presence or absence of early systolic retrograde coronary flow. Hearts were excised 2 h after reperfusion and examined histopathologically. The clamping time tended to be longer in dogs with early systolic retrograde coronary flow. Neutrophil infiltration was observed in the myocardium of dogs without systolic retrograde flow (n = 9); hemorrhage was rarely detectable and the myocardium maintained a bundle form. However, the bundle form of the myocardium became rough, and the severity of the incidence of hemorrhage tended to increase as the ratio of the diastolic coronary flow velocity to systolic velocity (DSVR) decreased. Vacuolar degeneration of the myocardium was also observed in hearts with a relatively low DSVR. In the group with systolic retrograde flow (n = 3), hearts were characterized by coagulation necrosis, marked vacuolar degeneration of the myocardium and diffusely distributed red cells in the intermyocytes. Systolic antegrade flow velocity was much reduced in this group, resulting in a markedly increased DSVR. These findings appeared to be related to severe myocardial damage. Coronary flow velocity patterns immediately after successful reperfusion appear to reflect the pathologic characteristics of the reperfused myocardium in dogs with AMI.


Transesophageal pulsed Doppler echocardiographic study of systolic flow velocity patterns of the pulmonary vein in patients with atrial fibrillation.


Difference in systolic motion velocity of the left ventricular posterior wall in patients with asymmetric septal hypertrophy and prior anteroseptal myocardial infarction: evaluation by pulsed tissue Doppler imaging.


Left atrial contribution to left ventricular filling in patients with mitral stenosis: combined analysis of transmitral and pulmonary venous flow velocities.


Echocardiographic characteristics and causal mechanism of physiologic mitral regurgitation in young normal subjects.


Clinical application of pulsed Doppler tissue imaging for assessing abnormal left ventricular relaxation.


単冠動脈症を合併した肥大型心筋症の1例

単冠動脈症を合併した肥大型心筋症の1例


Evaluation of left atrial appendage function by measurement of changes in flow velocity patterns after electrical cardioversion in patients with isolated atrial fibrillation


Tricuspid inflow and regurgitant flow dynamics after mitral valve replacement: Differences relating to surgical repair of the tricuspid valve

Changes in tricuspid inflow and regurgitant flow dynamics were evaluated in patients with functional tricuspid regurgitation (TR) who underwent mitral valve replacement (MVR) with and without tricuspid annuloplasty (TAP). In a group of 30 patients, all with atrial fibrillation, 15 underwent TAP performed according to the modified De Vega technique; the remaining 15 did not undergo TAP. Patients were studied before and serially after surgery, using pulsed and color Doppler echocardiography. The mean follow up was 4.7 years in the TAP group and 5.1 years in the non-TAP group. In the TAP group, immediately after surgery, the area of the TR jet decreased markedly, and the deceleration time of the tricuspid inflow velocity wave was significantly prolonged compared with that before surgery. By contrast, in the non-TAP group, both the area of the TR jet and deceleration time of tricuspid inflow velocity were virtually unchanged. The area of the TR jet remained small for a long period in the TAP group, but in non-TAP patients was increased in four cases over seven years, with two patients developing right-sided heart failure. Recent data showed the area of the TR jet to be significantly smaller, with maximum tricuspid inflow velocity significantly increased, and deceleration time of the tricuspid inflow velocity wave significantly prolonged in the TAP group compared with the non-TAP group. In patients with functional tricuspid regurgitation undergoing MVR, concomitant TAP may cause mild tricuspid stenosis, but produces sustained preventive effects against TR. Careful follow up is needed in patients who have not undergone TAP, as TR is not markedly decreased and may even be exacerbated. Aggressive TAP is recommended in patients showing dilatation of the tricuspid annulus, even if TR is mild.


Cross sectional echocardiographic demonstration of the mechanisms of abnormal interventricular septal motion in congenital total absence of the left pericardium.


Development of an imaging system using fluorescent labeling substances excited by infrared rays.


Mutations in a hydrophilic part of the core gene of hepatitis C virus from patients with hepatocellular carcinoma in China.


Transesophageal pulsed Doppler echocardiographic evaluation of left atrial systolic performance in hypertrophic cardiomyopathy: combined analysis of transmitral and pulmonary venous flow velocities.


Transesophageal echocardiographic prediction of initially successful electrical cardioversion of isolated atrial fibrillation. --- Effects of left atrial appendage function.


心磁図法によるQTc dispersion:心筋梗塞による検討

心磁図法によるQTc dispersion:心筋梗塞による検討

The Journal of Japan Biomagnetism and Bioelectromagnetics Society


内視鏡実施時の循環動態研究委員会報告

内視鏡実施時の循環動態研究委員会報告


Signal averaged electrocardiogram after exercise in patients with mitral valve prolapse

While late potentials are correlated with an increased incidence of ventricular tachycardia, they are not necessarily a good predictor of ventricular electrical instability in patients with mitral valve prolapse (MVP). Our objective was to determine whether the signal averaged electrocardiogram (SAECG) after exercise can discriminate groups with a higher frequency of ventricular arrhythmia from those without. The SAECG was recorded before and after treadmill exercise in 20 normal subjects (N group), 20 patients with MVP (MVP group) and 10 patients with old myocardial infarction (MI group). Five patients (25%) in the MVP group and two patients (33%) in the MI group had late potentials before exercise. Late potentials in the MI group did not disappear with exercise, whereas they disappeared with exercise in two patients in the MVP group. The results suggest that the late potentials observed in patients with MVP differ in nature from those with old myocardial infarction and are not always related to lethal arrhythmia.


Risk factors and incidence of coronary artery lesions in patients with abdominal aortic aneurysms


The 'Sail sound' and tricuspid regulation in Epstein's anomaly: the value of echocardiography in evaluating their mechanisms.


Tricuspid inflow and regurgitant flow dynamics after mitral valve replacement: differences relating to surgical repair of the tricuspid valve.


Concealed left ventricular hypertrophy and diastolic dysfunction in hypertrophic cardiomyopathy in the presence of acute left ventricular volume overload: a case report.


Left atrial systolic performance in the presence of elevated left ventricular end-diastolic pressure: evaluation by transesophageal pulsed Doppler echocardiography of left ventricular inflow and pulmonary venous flow velocities.


Dynamics and relationships between serum lipoprotein(a) and fibrinolysis factors in patients with coronary artery disease.


Relationship between the angiotensin converting enzyme gene polymorphism and the effects of Enalapril on left ventricular hypertrophy and impaired diastolic filling in essential hypertension: M-mode and pulsed Doppler echocardiographic studies.

To investigate the relationship between the angiotensin converting enzyme (ACE) gene polymorphism and the effects of the ACE inhibitor enalapril on left ventricular hypertrophy and impaired diastolic filling. Enalapril (5-10 mg/day) was administered for 12 months to 60 previously untreated patients with essential hypertension. M-mode and pulsed Doppler echocardiography were performed before and after treatment, and changes in various parameters after treatment with enalapril were examined. ACE gene polymorphism was examined by the polymerase chain reaction method and the patients were classified as having the 190 bp deletion homozygous (DD) genotype, the 490 bp insertion homozygous (II) genotype or the 490 bp insertion 190 bp deletion heterozygous (ID) genotype. The DD genotype was observed in 10 patients (17%), the ID genotype in 24 patients (40%) and the II genotype in 26 patients (43%). Plasma ACE activity before treatment with enalapril was significantly higher in seven patients with DD genotype than it was in 18 patients with ID genotype and in 14 patients with II genotype. In all of the 60 patients, the left ventricular mass index, the peak atrial systolic velocity:early diastolic velocity ratio and the deceleration time from the peak of the early diastolic wave to the baseline in transmitral flow velocity were decreased significantly after treatment with enalapril. The changes in left ventricular mass index and atrial systolic velocity:early diastolic velocity ratio after enalapril administration were significantly greater in the DD genotype group than they were in the other two genotype groups. Enalapril-induced regression of left ventricular hypertrophy and improvement in left ventricular impaired diastolic filling were significantly greater in the DD genotype group than they were in the ID and II genotype groups, suggesting that the circulating and tissue renin-angiotensin systems, particularly the former system, are most active in hypertensive patients with the DD genotype.


Influence of left atrial pressure on left atrial appendage flow velocity patterns in patients in sinus rhythm.

Journal of the American Society of Echocardiography


Relationship between pulmonary capillary wedge V wave and transmitral and pulmonary venous flow velocity patterns in various heart diseases.

A large V wave in a pulmonary capillary wedge pressure (PCWP) tracing is characteristic of mitral regurgitation. However, the V wave is often increased in patients without or with no significant mitral regurgitation. The V wave was in the PCWP tracing investigated in 65 patients using transmitral flow (TMF) and pulmonary venous flow (PVF) velocity patterns obtained by transesophageal pulsed Doppler echocardiography. A large V wave was defined if the peak V wave minus the mean PCWP (V-mPCWP) was greater than 7 mmHg. Three study groups were formed: 15 patients with large V waves and significant mitral regurgitation, 15 patients with large V waves with no significant mitral regurgitation, and 35 patients with small V waves. The mPCWP and left ventricular end-diastolic pressure were greatest in the group with large V waves and no significant mitral regurgitation. Peak early diastolic TMF and PVF velocities were significantly greater in the two groups with large V waves. The peak second systolic PVF velocity was lowest in the group with large V waves and significant mitral regurgitation, followed by the group with large V waves and no significant mitral regurgitation. The V-mPCWP was positively correlated with the peak early diastolic TMF and PVF velocities and negatively correlated with the peak second systolic PVF velocities. Additionally, mitral regurgitation severity in patients with large V waves and significant mitral regurgitation was positively correlated with the peak early diastolic TMF and PVF velocities and negatively correlated with the peak second systolic PVF velocity. These results suggest that large V waves in PCWP tracings appear not only in severe mitral regurgitation, but also in any condition with markedly elevated left ventricular end-diastolic pressure. Combined analysis of the TMF and PVF velocity patterns is helpful in determining the etiology of these hemodynamic abnormalities.


Evaluation of Myocardial Sympathetic Nerve Function in Patients With Mitral Valve Prolapse Using Iodine-123-Metaiodobenzylguanidine Myocardial Scintigraphy

123I-Metaiodobenzylguanidine心筋シンチグラフィーによる僧帽弁逸脱の交感神経機能評価


Influence of aging on left atrial appendage flow velocity patterns in normal subjects.


Changes in left ventricular inflow and pulmonary venous flow velocities during preload alteration on hypertrophic cardiomyopathy.


Changes in transmitral and pulmonary venous flow velocity patterns after cardioversion of atrial fibrillation.


Detection of Different Quasispecies of Hepatitis C Virus Core Region in Cancerous and Non-cancerous Regions.

Biochemical and Biophysical Research Communications


Stimulation of rat hepatocyte albumin synthesis by ascites from patients with cirrhosis.

The Tokushima Journal of Experimental Medicine


右心内転移をきたした悪性黒色腫の1例

右心内転移をきたした悪性黒色腫の1例


Malignant melanoma metastasizing to the right heart: a case report.


A Case of Cardiac Amyloidosis Presenting with Mid- to Late Diastolic Retrograde Flow from the Left Atrium to the Pulmonary Vein: Transesophageal Pulsed Doppler Echocardiographic Observations.


Clinical significance of the apical late systolic ejection murmur: a new phonocardiographic sign indicating dynamic mid-left ventricular obstruction.


A 90-year old patient with atrial septal defect and sinus rhythm

A 90-year old patient with an atrial septal defect (ASD) and sinus rhythm, but no history of atrial fibrillation of heart failure is presented. Literature searches revealed no similar report of such a case. In addition, this patient represents the oldest documented patients with ASD associated and sinus rhythm.


64チャンネル磁束計を用いた小腸磁界の測定

64チャンネル磁束計を用いた小腸磁界の測定

The Journal of Japan Biomagnetism and Bioelectromagnetics Society


特発性心筋症における初期QRSベクトルの信号源

特発性心筋症における初期QRSベクトルの信号源


L-アルギニン静脈注射による自律神経活動の影響:心拍変動解析による検討

L-アルギニン静脈注射による自律神経活動の影響:心拍変動解析による検討


長時間運動負荷後の回復過程のエネルギー代謝と自律神経活動の検討‐呼気ガス分析と心拍変動解析による検討


Heart rate variability during painful medical procedures(Percutaneous ethanol injection therapy)

Electrocardiology '96 from the cell to the body surface


Prevention of posttranfusion hepatitis by screening with second-generation anti-HCV antibody and clinical features of HCV infection


Systolic and diastolic mitral regurgitation in a patient with annulo-aortic ectasia demonstrated by color Doppler flow imaging.


Peculiar patterns of aortic regurgitation and carotid pulse due to dysfunction of a Medtronic Hall prosthetic valve: a case report.


Possible mechanisms of mitral regurgitation in dilated hearts: a study using transesophageal echocardiography.


Assessment of left atrial pressure and volume changes during atrial systole with transesophageal pulsed Doppler echocardiography of transmitral and pulmonary venous flow velocities.


ADP-dependent activation of ATP-sensitive K+ channels in cultured porcine coronary artery smooth muscle cells by tilisolol hydrochloride.


Development of fluorescence-emitting antibody labeling substance by near-infrared ray exciation.

Bioorganic & Medicinal Chemistry Letters


Predisposing factors of severe mitral regurgitation in idiopathic mitral valve prolapse.


A case of mitral valve prolapse simulating a mitral tumor or vegetation.


Pulmonary and systemic venous flow patterns assessed by transesophageal Doppler echocardiography in congenital absence of the pericardium.


The first heart sound in atrial septal defect with reference to atrioventricular valve motion and hemodynamics.


僧帽弁逸脱における運動負荷時の心拍変動スペクトルの検討

僧帽弁逸脱における運動負荷時の心拍変動スペクトルの検討


64チャンネルSQUID磁束計を用いた胃活動電流の測定‐臨床的有用性の検討‐

64チャンネルSQUID磁束計を用いた胃活動電流の測定‐臨床的有用性の検討‐


高温超伝導SQUIDを用いた胃運動機能の評価

高温超伝導SQUIDを用いた胃運動機能の評価


胃磁検出のための低周波信号処理

胃磁検出のための低周波信号処理


前壁心筋梗塞症および健常例の初期QRSベクトルの信号源推定

前壁心筋梗塞症および健常例の初期QRSベクトルの信号源推定


Histopathologic studies of innervation of normal and prolapsed mitral valves of humans.


Differences in the entire nucleotide sequence between hepatitis B virus genomes from carriers positive for antibody to hepatitis B e antigen with and without active disease.

The entire nucleotide sequence was determined for eight hepatitis B virus (HBV) genomes from three symptom-free carriers, two patients with chronic persistent hepatitis and one patient with chronic active hepatitis, who were positive for antibody to hepatitis B e antigen (HBeAg). The two patients with chronic persistent hepatitis were tested again after they developed chronic active or fulminant hepatitis, making a total of eight samples. Six had a point mutation in the preC region prohibiting the encoding of HBeAg precursor, while the remaining two had a deletion of 8 or 21 nucleotides within the X gene upstream of the preC transcription initiation sites which would affect the X gene and the putative preC/C promoter. Most genomes from the three symptom-free carriers and the two patients with chronic persistent hepatitis, with HBV DNA levels of 10(2)-10(3)/ml, had deletion, frameshift mutation, initiation failure or a premature stop codon, rendering them replication-incompetent. In contrast, such mutations were rarely seen in HBV genomes from the two patients with chronic persistent hepatitis after they had developed active or fulminant hepatitis and from the patient with chronic active hepatitis, all of whom had vigorous HBV replication with serum HBV DNA from 10(6) to 10(9)/ml. Unique mutations for amino acid changes were more frequent in HBV genomes with a higher replicative activity. These results indicate two kinds of HBV genomes with an HBeAg-minus phenotype, one with defects seriously affecting viral replication and the other without such defects, which would account for different clinical profiles in carriers with antibody to HBeAg.


Serologic, virologic, and histologic characteristics of chronic phase hepatitis C virus disease in children infected by transfusion


Ribosome recycling factor (ribosome releasing factor) is essential for bacterial growth.

Proceedings of the National Academy of Sciences of the United States of America


Noninvasive localization of accessory pathways by magnetocardiographic imaging

The magnetocardiogram (MCG) is a newly developed method that helps localize a cardiac current source. To test the clinical accuracy of a 7-channel biomagnetic system in the localization of early ventricular depolarization sites, the MCGs of 14 patients with Wolff-Parkinson-White (WPW) syndrome were recorded in a radiofrequency-shielded room. The locations of early ventricular depolarization sites were classified by standard 12-lead electrocardiograms (ECGs) and body surface isopotential mapping. The accessory pathways of 3 patients with WPW syndrome were located in the right free wall and in 11 patients in the left free wall. The three-dimensional (3-D) dipole location was computed every 2 ms from the onset of the QRS complex by the least-square method. These 3-D dipole locations were projected onto a gated magnetic resonance image in order to visualize the propagation of the calculated ventricular source. The results were compared with those obtained by body surface isopotential mapping, and electrocardiographic and electrophysiologic studies. The location of the deduced current dipole at 20 ms correlated well with the location of the accessory pathway by the body surface mappings in 12 of the 14 patients with WPW syndrome. The MCG is capable of precisely determining the 3-D location of a current source in a noninvasive manner and may be of potential benefit in the treatment of WPW syndrome by catheter ablation.


Incidences of hepatitis C virus (HCV) antibodies and HCV-RNA in blood donors and patients with liver diseases in the inshore area of the Yangtze river.

The Nantong area is a high risk region for primary hepatocellular carcinoma (PHC) in the inshore area of the Yangtze River. However, no detailed data are available about hepatitis C virus (HCV) infection in this area. We examined the incidences of anti-HCV and HCV-RNA in blood donors with hepatitis B surface antigen (HBsAg)- and hepatitis B core antibody (HBcAb)-negative and patients with chronic liver diseases in the Nantong area at Nantong Medical College, Jiangsu Province, the People's Republic of China. The incidences of HBV markers (HBsAg and/or HBcAb), anti-HCV (C100-3), second generation anti-HCV, HCV-RNA and any marker of HCV in the Nantong area were found to be: 0.0, 0.7, 0.4, 0.2 and 0.7% in donor bloods; 16.9, 0.0, 3.4, 15.7 and 16.9% in patients with acute hepatitis; 82.8, 2.7, 4.8, 7.5 and 10.2% in those with chronic hepatitis; 86.4, 4.5, 9.1, 4.5 and 11.4% in those with liver cirrhosis; 87.5, 6.3, 0.0, 0.0 and 6.3% in those with PHC; and 21.8, 1.3, 1.3, 0.0 and 1.3% in patients without liver diseases, respectively. Although the Nantong area is a high risk region for PHC, these data suggest that HCV infection is not an important aetiological factor for PHC in this area.

Journal of Gastroenterology and Hepatology


Virological features of hepatitis C virus infection in patients with liver diseases in the inshore area of the Yangtze River

The Tokushima Journal of Experimental Medicine


Endoscopic therapy using monopolar and bipolar snare with a high-frequency current in patients with a pacemaker


Kallikrein-kinin system during the cold pressor test in cirrhotic rats.


HCV infection and its clinical features in recipients of blood screened for HCV (C100-3) antibody.


Hemopneumothorax secondary to multiple cavitary metastasis in angiosarcoma of the scalp

We report a case of hemopneumothorax secondary to multiple cavitary metastasis in the angiosarcoma of the scalp in an 86-year-old woman, who died of respiratory failure. At autopsy, multiple cavities were found in both lungs. Histologic specimen of the cavitary metastasis of the lung showed that tumor cells proliferated forming several tubular spaces and these tubular spaces seemed to communicate with the central cyst. These findings suggested that imperfect vessel-like structures of the cavitary metastasis are likely to break down and finally grow up to large thin-walled cavities.


僧帽弁逸脱における血中遊離型および硫酸抱合型カテコラミンの変動

僧帽弁逸脱における血中遊離型および硫酸抱合型カテコラミンの変動


心磁図法によるPベクトルの位置推定

心磁図法によるPベクトルの位置推定


肝硬変患者における自律神経機能:体表面平均加算化心電図法を用いた検討

肝硬変患者における自律神経機能:体表面平均加算化心電図法を用いた検討


心磁図法による心房性再分極波(Ta波)の検討

心磁図法による心房性再分極波(Ta波)の検討

The Journal of Japan Biomagnetism and Bioelectromagnetics Society


心筋梗塞症の初期QRSベクトルと心室再分極ベクトル-心磁図法による電流源の位置

心筋梗塞症の初期QRSベクトルと心室再分極ベクトル-心磁図法による電流源の位置


Time- and frequency-domain analyses of signal averaged electrocardiograms in patients with diabetes mellitus

We recorded the signal-averaged electrocardiography (SAECG) of patients with diabetic retinopathy in order to clarify whether a ventricular conduction disturbance can be detected by time- or frequency-domain analysis of the SAECG. Twenty-four normal subjects (N group) and 20 patients with diabetic retinopathy [diabetes mellitus (DM) group] were studied. On time-domain analysis, the duration of the filtered QRS (f-QRS), the duration of the terminal QRS below 40 microV (LAS40) and the root-mean-square amplitude of the terminal 40 msec (RMS40) were measured. The frequency-domain analysis was performed using two windows. In each window, the ratio of the area under the spectral curve from 40 to 100 Hz was compared with that from 0 to 40 Hz and the area from 20 to 50 Hz was compared with that from 0 to 20 Hz. The LAS40 of the DM group was significantly prolonged when compared with the N group. The area ratio from 40 to 100 Hz versus 0 to 40 Hz significantly increased in the DM group when compared with the N group. These results suggest that SAECG can be used to detect abnormal electrical signals due to diabetic microangiopathy. Moreover, high frequency components of 40 to 100 Hz at the terminus of the QRS wave were most sensitive for abnormalities due to diabetic microangiopathy.


Circadian profile of heart rate variability in mitral valve prolapse syndrome


Time- and frequency-domain heart rate variabilities in patients with liver cirrhosis


Relationship between the ischemic myocardium and focus of ventricular tachycardia in old myocardial infarction


Serologic, virologic, and histrogic characteristics of chronic phase hepatitis C virus disease in children infected by transfusion


Prevalence of HCV-antibodies And HCV-RNA In Donor Blood In Tokushima Prefecture


Comparative phonocardiographic, echocardiographic and Doppler echocardiographic evaluation of normally functioning Medtrinic-Hall and Bj rk-Shiley mitral prosthetic valves.


Serologic, virologic, and histologic characteristics of chronic phase hepatitis C virus disease in children infected by transfusion.PEDIATRICS (,) /,


HCV(C100-3)抗体スクリーニング後の輸血後肝炎例におけるHCV感染状況と病態に関する研究


心房興奮伝播のMRI画像上の表示‐心磁図法による電流dipoleの位置推定‐

心房興奮伝播のMRI画像上の表示‐心磁図法による電流dipoleの位置推定‐


Prediction of the site of origin of ventricular premature beat by magnetocardiogram

心臓磁界測定による心室性期外収縮の心室最早期興奮部位の推定

心磁図による診断法を確立するために，生体内の電流源を三次元的に推定する心磁図法と，心電図同期MRI断層法を併用して，心室性期外収縮発生源の位置を推定した．推定された値は，体表面電位図法から推定される発生源とほぼ一致し，診断学的にも有用であることがわかった．


Radioimmunoreactive plasma bradykinin levels and histological changes during the course of cerulein-induced pancreatitis in rats.

The plasma bradykinin (BK) and serum amylase levels and histological changes in rats during the course of acute pancreatitis induced by a large dose of cerulein were examined. Animals were given four intraperitoneal injections of 20 micrograms/kg body wt of cerulein at hourly intervals. The plasma concentration of BK-like immunoreactivity (BK-LI), measured by a highly sensitive and specific radioimmunoassay established in this study, was found to reach a peak 6 h after the first injection of cerulein and then to remain elevated. On the other hand, the serum amylase and the histological alterations (i.e., interstitial edema, vacuolization, and inflammatory infiltration) were maximal 9 h after the first injection and returned to nearly normal after 24 h. These observations suggest that the BK generation is indicative of the participation of the kallikrein-kinin system in the pathophysiological change and that the plasma BK-LI level is a good marker of cellular damage and inflammation within the pancreas during the course of acute pancreatitis.


Epidemiological characteristics of the incidence of hepatitis C virus (C100-3) antibodies in patients with liver diseases in the inshore area of the Yangtze river.

The Nantong area is an endemic region of hepatitis B virus (HBV) infection in the inshore area of the Yangtze River. However, no detailed data are available about hepatitis C virus (HCV) infection in this area. In this study recent reports are reviewed about the incidence of viral hepatitis and primary hepatocellular carcinoma (PHC) in China, and it is shown that the Nantong area is a high risk region for PHC. This study reports on the incidence of antibody to HCV (anti-HCV) in patients with chronic liver diseases in the Nantong area; investigated in collaboration with members of the Nantong Medical College, Jiangsu Province, the People's Republic of China. The incidence of anti-HCV (C100-3) in the Nantong area was: 0.67% (three of 451) in donor blood; 0.0% (none of 89) in patients with acute hepatitis; 2.7% (five of 186) in those with chronic hepatitis, 4.5% (two of 44) in those with liver cirrhosis; 6.3% (one of 16) in those with PHC; and 1.3% (one of 78) in patients without liver disease. The incidence of hepatitis B surface antigen in the Nantong area was: 15.7% (14 of 89) in patients with acute hepatitis; 81.2% (151 of 186) in those with chronic hepatitis; 81.8% (36 of 44) in those with liver cirrhosis; 87.5% (14 of 16) in those with PHC; and 20.5% (16 of 78) in patients without liver disease. Although the Nantong area is a high risk region for PHC, these data suggest that HCV infection is not an important aetiological factor for PHC in this area.

Journal of Gastroenterology and Hepatology


心磁図法によるQRS初期ベクトルの位置推定‐MRI画像上への表示

心磁図法によるQRS初期ベクトルの位置推定‐MRI画像上への表示


SQUIDを用いた心房興奮伝播のMRI画像上の表示

SQUIDを用いた心房興奮伝播のMRI画像上の表示

The Journal of Japan Biomagnetism and Bioelectromagnetics Society


心室性不整脈の発生源の推定-心電図と心磁図の比較

心室性不整脈の発生源の推定-心電図と心磁図の比較


マラソン前後における血中遊離型および硫酸抱合型カテコラミンの変動

マラソン前後における血中遊離型および硫酸抱合型カテコラミンの変動


HCV (C100-3) 抗体スクリーニング後の輸血後肝炎および同疑診例の感染源に関する検討


輸血用血液におけるHCV(C100-3)抗体スクリーニングの効果

輸血用血液におけるHCV(C100-3)抗体スクリーニングの効果


Incidences of hepatitis C virus(HCV) antibodies and HCV-RNA in blood donors and patients with liver diseases in the Inshore Area of the yangtze River.


Single moving dipole obtained from magnetic field of the heart in patients with left ventricular hypertrophy

Magnetocardiograms (MCGs) were recorded by means of a second-derivative SQUID (superconducting quantum interference device) magnetometer in 20 normal subjects and 28 patients with left ventricular overload to analyze the activation sequence of the heart and amplitude of estimated current source. In the normal subjects, the dipole was directed to the left and gradually superiorly 40 ms after the beginning of the QRS wave mainly due to the activation of the left ventricle. In the patients with hypertension, the direction and location of the dipoles were similar to those of the normal subjects, but their dipole moments were increased. In the patients with mitral regurgitation, the dipoles of late QRS were directed more inferiorly than in the normal subjects and their amplitude was increased. In the patients with aortic valve disease, the amplitude of the dipoles was increased markedly and their location was deviated more to the left than the dipoles of the normal subjects. We established the criterion for diagnosis of LVO from the dipole moment of 50 ms of 3.13 x 10(-3) A or more. The sensitivity of this criterion is significantly higher in the diagnosis of left ventricular overload than the electrocardiogram (ECG). The present study shows that the moving dipole method is useful to determine the increased electromotive force in patients with left ventricular overload and that sensitivity in diagnosis of left ventricular overload is increased.

Single moving dipole法により，高血圧，僧帽弁閉鎖不全，大動脈弁狭窄の症例について，推定dipoleの値を経時的定量的に求めた．健常例との比較により診断率の精度を比較検討し，各疾患の特徴と診断基準を明らかにした．


左室負荷疾患における心磁図-Isomagnetic mapおよび single movingmoving dipole法による診断‐

心磁図による診断法を確立する目的で，磁界図の等価二重極を用いて推定dipoleを求めた．これを各時相で重ね合わせて，経時的に移動する moving dipoleとして表現した．健常群と左室負荷疾患群の moving dipoleを比較すると，電流源の大きさや経時変化および位置の情報を捉えやすく，疾患の特徴をよく反映していた．さらに電流源から体表面までの距離の影響を受けにくく，診断学的な有用性が認められた．


正常例の初期QRS波のdipoleの位置推定‐心電図同期MRI画像上への表示‐

正常例の初期QRS波のdipoleの位置推定‐心電図同期MRI画像上への表示‐


心磁図法による心室最早期興奮部位の推定‐磁界分布図と体表面電位図·心表面マッピングとの対比‐


Effects of vasopressin on K+ channels of vascular smooth muscle cells


Effect of screening for hepatitis C virus antibody and hepatitis B virus core antibody on incidence of post-transfusion hepatitis


Diagnosis of ventricular hypertrophy by single moving dipole

磁界図の等価二重極を用いて推定dipoleを求めた．これを各時相で重ね合わせて，経時的に移動する moving dipoleとして表現した．健常例と本態性高血圧症例，僧帽弁閉鎖不全症例大動脈弁凶作券閉鎖不全症例について moving dipoleを比較し，診断上の有用性を報告した

International Conference on Biomagnetism.


A case of melanosis duodeni in which pigmentation disappeared after the discontinuation of hydralazine administration.


Prevention of posttransfusional non-A, non-B hepatitis by a screen test for hepatitis C virus antibody of donor bloods.

The Tokushima Journal of Experimental Medicine


HISTOCHEMICAL AND BIOCHEMICAL STUDIES ON GUANASE IN THE HUMAN AND RAT KIDNEY


Histochemical and biochemical studies on guanase in kidney.


Purification of human liver guanase and characterization of antibody against it by immunoblotting.


Elevation of the ulcer base in cases treated with an H2-blocker; difference between an elevated type gastric ulcer scar and a white elevated lesion.


Elevation of the ulcer base in cases treated with an H2-blocker. Difference between an elevated type of gastric ulcer scar and a white elevated lesion.


Characterization of antibody against human liver guanase by immunoblotting and immunohistochemical staining on human liver guanase by a direct labelling antibody-enzyme method

The Journal of Histochemistry and Cytochemistry


Cytochemical demonstration of guanase in human liver using yellow tetrazolium


Cytochemical demonstration of guanase in human liver using yellow tetrazolium.

Histochemical studies of human guanase (guanine deaminase) have seldom been undertaken, in part because of technical difficulties which result in heavy background staining. We reported a modified procedure for histochemical demonstration of guanase in human tissues involving hydrolytic deamination of the substrate guanine to xanthine via guanase, and then oxidation of xanthine to uric acid, with concomitant reduction of nitrotetrazolium blue (NBT). In this report, we describe a modification of this method for cytochemical demonstration of guanase at the fine structural level using yellow tetrazolium in place of NBT for determination of the intracellular distribution of guanase in human hepatocytes. In the hepatocytes, the reaction products were seen to be concentrated in the nucleus, in mitochondria, cisternae of the smooth and/or rough-surfaced endoplasmic reticulum, and lysosomes. The precise locations of the reaction product in the cisternae of the nuclear envelope, chromosomes, and nucleus could not be determined. However, the reaction products in the mitochondria were clearly seen to be located in the spaces of cristae. This information of the intracellular distribution of guanase in normal hepatocytes will be useful in determining the physiological role of this enzyme and in further studies on diseased hepatocytes including those in non-A non-B hepatitis.


Clinical value of the guanase screening test in donor blood for prevention of posttransfusional hepatitis.


An elevated type of gastric ulcer scar in patients treated with cimetidine.


Histochemical distribution of guanase in human tissues with guanase in bicine buffer as substrate.


A new device of esophageal dilatation for the severe and recurrent post- operative stenotic stoma.


Relationship between the guanase activity in donor blood for transfusion and the incidence of post-transfusional non A non B hepatitis.


Histochemical demonstration of guanase in human liver using guanine in bicine buffer as substrate.


Clinical value of the determination of serum guanase activity. Studies on patients and experimental data from mongrel dogs and cultured rat hepatocytes.


Trial diagnostic test kit for the determination of guanase activity using 8-azaguanine solution in dotite bicine buffer as substrate.


A sensitive new method for measurement of guanase with 8-azaguanine bicine bis-hydroxy ethyl glycine buffer as substrate.


Relationship Between the Ratio of Peak Early Diastolic Transmitral Flow and Mitral Annular Velocities and the Plasma B-Type Natriuretic Peptide (BNP) Concentration in Patients with Atrial Fibrillation: Assessment by Simultaneous Recording of Transmitral Flow and Mitral Annular Velocity.

Journal of the American College of Cardiology


Evaluation of the effects of mastication and swallowing on gastric motility using electrogastrography

The influence of mastication and swallowing on gastric motor function was evaluated by electrogastrography (EGG) and abdominal ultrasonography. The subjects were 30 elderly patients with tubal feeding without mastication and swallowing (T group) and 30 elderly controls who processed food by mastication and swallowing (C group). Gastric motor function was percutaneously examined before and after the ingestion of 250 ml of a liquid diet using an electrogastrograph (NIPRO EGG, A and D, Tokyo, Japan). The cross-sectional area of the gastric antrum was measured at 1 and 30 min after the start of ingestion of the liquid diet by external ultrasonography of the abdomen, and the gastric excretion function was evaluated. Furthermore, the spectral analysis of heart rate variability was performed using Holter electrocardiograms before and after ingestion. The low frequency power (LF power, 0.04-0.15 Hz), high frequency power (HF power, 0.15-0.40 Hz), and the LF/HF ratio were determined. The peak amplitude at 3 cycles per minute (cpm) was significantly increased after ingestion in the C and T groups (p<0.05), and the ratio of increase was significantly lower in the T group (p<0.05). The mean amplitude for the brady-gastria and tachy-gastria was significantly higher in the T group than in the C group (p<0.05). The gastric excretion function, as evaluated by external ultrasonography of the abdomen, was significantly lower in the T group than in the C group (p<0.05). An analysis of heart rate variability demonstrated that the HF power, a parameter of parasympathetic activity, after ingestion was significantly higher in the C group than in the T group (p<0.05). No changes in LF power or LF/HF ratio, parameters of sympathetic activity, were induced by ingestion in either the C or T groups. The parasympathetic nerve dominantly controls gastric motor function, but autonomic nervous activity is reduced in patients who are unable to masticate and swallow food, resulting in adverse effects on gastric motor function and excretion function. Mastication and swallowing not only prepare food for passage from the oral cavity to the esophagus but are also important in terms of subsequent events that occur in stomach. It has been proposed that autonomic nervous activity might be involved in mastication and swallowing.

The Journal of Medical Investigation : JMI


Ghrelin Protects Myocardium Against Ischemia/Reperfusion Injury via Inhibiting Myocardial Apoptosis.


小児に対し安全に施行しえたERCPの1例

小児に対し安全に施行しえたERCPの1例


Long-term left ventricular morphologic change in hypertrophic cardiomyopathy: a relationship with development of atrial fibrillation.

Journal of the American Society of Echocardiography


Pseudonormalization of the transmitral inflow Doppler velocities re-evaluated in relation to the left atrial function using tissue strain imaging.


Quantitative assessment of biphasic response to dobutamine by tissue strain echocardiography.


Quantitative and Direct Assessment of the Left Atrial Reservoir Function Using Tissue Strain Imaging.


Effect of Left Ventricular Geometry on Systolic Myocardial Velocity Gradient in Patients With Hypertension.


肝臓におけるグアナーゼ研究の新しい可能性

肝臓におけるグアナーゼ研究の新しい可能性

Japanese Journal of Medicine and Pharmaceutical Science


包括評価制度導入後の潰瘍性大腸炎に対する白血球除去療法

包括評価制度導入後の潰瘍性大腸炎に対する白血球除去療法


包括評価制度導入後の急性血液浄化療法

包括評価制度導入後の急性血液浄化療法


Better Choice of Color Tissue Doppler Imaging Couped with High Dose Dobutamine Stress Echocardiography for Detection Coronary Artery Stenoosis.


Assessment of the Left Ventricular Diastolic Function Independent of Cardiac Translation Using a Newly Developed Tissue Strain Imaging.


Impact of Angiotensin II receptor Antagonist on Left Ventricular Myocardial Function on Hypertensive Hypertrophy: Assessment of Myocardial Velocity Profile and Plasma Vasoactive Peptide.


偶発症対策のモニタリング．内視鏡検査中の自律神経活動及びQT dispersionの変化


逆流性食道炎における胃運動機能の検討 --- 胃電図および超音波法による胃排泄能の検討

消化性潰瘍研究，第20集(四国ESDフォーラム編集，伊東 進監修)

消化性潰瘍研究，第20集(四国ESDフォーラム編集，伊東 進監修)


肝硬変における門脈血流速度の変化

肝硬変における門脈血流速度の変化


肝星細胞におけるエストロゲン受容体βの発現

肝星細胞におけるエストロゲン受容体βの発現


H.pylori除菌後に発見された胃癌症例の経験

H.pylori除菌後に発見された胃癌症例の経験


グアナーゼからみたB型肝炎とC型肝炎との差異

グアナーゼからみたB型肝炎とC型肝炎との差異


選択的エストロゲン受容体モジュレーター,idoxifeneの抗酸化作用,抗アポトーシス作用と肝線維化抑制作用


肝細胞癌に対する診断と治療

肝細胞癌に対する診断と治療


Biomagnetic measurement of gastric mechanical motility using a high-temperature SQUID imaging.


Source localization of initial QRS vector in patients with idiopathic cardiomyopathy : Comparison with normal subjects and patients with anterior myocardial infarction.


Myocardial gradient as an indicator of regional myocardial contraction after cardiac surgery: a study with tissue Doppler imaging.


Regional left ventricular myocardial function in hypertrophic cardiomyopathy: assessment by tissue Doppler imaging and 123 I-b-methyliodopheny1 pentadecanoic acid scintigraphy.


Assessment of left ventricular myocardial viability using mitral annular descent velocity: a study with dobutamine stress pulsed tissue Doppler imaging.


消化器癌と遺伝子異常·治療

消化器癌と遺伝子異常·治療


Assessment of early diastolic left ventricular regional myocardial function in patients with hypertrophic cardiomyopathy using tissue Doppler imaging and magnetic resonance myocardial tagging.


Evaluation of left atrial relaxation abnormality using pulmonary venous flow velocity and interatrial septal motion.


Differentiation of left ventricular diastolic wall motion velocities between aortic and mitral regurgitation using tissue Doppler imaging.


Relationship between left ventricular regional wall motion abnormalities and mitral annular descent velocities in patients with myocardial infarction and dilated cardiomyopathy: a study with tissue Doppler imaging.


Relationship between left atrial appendage function and plasma concentration of atrial natriuretic peptide.


Influence of aging on early diastolic and atrial systolic motion dynamics of the left ventricular wall in normal subjects: Vector analysis of the wall motion velocities using pulsed tissue Doppler imaging.

Journal of the American Society of Echocardiography


Evaluation of left ventricular regional systolic wall motion velocity in hypertrophied hearts using pulsed tissue Doppler imaging.


Evaluation of electrical and mechanical discordance during atrial systole using pulsed tissue Doppler imaging.


長時間運動後のエネルギー代謝におよぼす影響

長時間運動後のエネルギー代謝におよぼす影響


腎癌など多彩な多臓器合併症を伴ったvon-Hippel-Lindau病の1例

腎癌など多彩な多臓器合併症を伴ったvon-Hippel-Lindau病の1例

The Japanese journal of clinical and experimental medicine


コラーゲン代謝動態における女性ホルモンの役割に関する検討

コラーゲン代謝動態における女性ホルモンの役割に関する検討

Japanese Journal of Medicine and Pharmaceutical Science


Clinical application of pulsed Doppler tissue imaging for assessing abnormal relaxation of the left ventricle.


Roles of left atrial appendage for left atrial hemodynamics by left atrial appendage clamping during cardiac surgery.


Assessment of myocardial circumferential shortening of the left ventricular wall using pulsed Doppler tissue imaging.


Non-invasive assessment of left ventricular relaxation by pulsed Doppler tissue imaging: comparison with cardiac catheterization.


Evaluation of left ventricular diastolic function in hypertrophied hearts using Doppler tissue imaging.


Evalution of left ventricular diastolic function in hypertrophied hearts using Doppler tissue imaging.


Coronary flow velocity immediately after reperfusion reflects myocardial microcirculation in canine acute myocardial infarction models.

Journal of the American College of Cardiology


Influence of left atrial pressure on the left atrial appendage flow velocity pattern.


レチノイドの肝線維化予防効果

レチノイドの肝線維化予防効果


内視鏡的粘膜切除を施行した十二指腸腺腫の1例

内視鏡的粘膜切除を施行した十二指腸腺腫の1例


ステロイド治療によりHCV-RNAの陽転化を認めた自己免疫性肝炎の1例

ステロイド治療によりHCV-RNAの陽転化を認めた自己免疫性肝炎の1例


Virological features of hepatitis C virus infection in patients with liver diseases in a high risk region for hepatocellular carcinoma in the inshore area of the Yangtze river

揚子江下流域肝癌多発地区における肝疾患の特性とHCVに関する研究

Hepatocellular carcinoma (HCC) is relatively common in China, especially in the inshore area of the Yangtze river including Nantong. In Nantong, most patients with liver disease were infected with HBV, but the prevalence of HCV infection was very low. In HCV infected patients with chronic liver disease, 45.6% were associated with HBV, and 61.4% had a history of blood transfusion. HCV genotype analysis shows that in Nantong genotype II was dominant, followed by genotype III. The genome sequences of the HCV core gene in Natong were more closely similar to those of previous isolates from Japan than those of American and French isolates. These results suggest that HCV infection is not an important etiological factor for HCC in a HBV endemic area, and that HCV in Nantong may have evolved epidemiologically with infections in Japan.

中国の揚子江下流域には肝癌多発地区が存在し,南通も含まれた.南通の供血者のHCV抗体陽性率は中国各地区と比較しても0.7%と低値で,しかも,慢性肝疾患におけるHCV抗体またはHCV-RNAの陽性率は11.6%と低く大半がHBV感染例(82.6%)で,HCV陽性例のHBVとの重複感染率も45.6%であった.さらに,非A非B型慢性肝疾患のHCV陽性率は36.0%で,そのうちの61.4%に輸血歴が認められた.南通のHCVゲノタイプはII型が大半を占め,次いでIII型優位で,日本の分布状況と近似し,HCVコア領域における遺伝子配列は日本型と最も高い相同性を示した.また,中国内の同じ肝癌多発地区でも,HCV感染率およびHBVとの重複感染率に地域差がみられたが,高いHBV感染率とゲノタイプの分布状況は共通していた.これらより中国肝癌多発地区においてはHCVよりHBVが肝癌発生の重要な因子と考えられ,さらに,HCVゲノムの存在状況が日本と近似していることよりHCVが日本より感染伝播した可能性が考えられた.


Effect of left atrial pressure on the rate of left ventricular relaxation estimated by mitral regurgitant flow velocity using continuous wave Doppler echocardiography in dilated heart.


Transesophageal pulsed Doppler echocardiographic evaluation of left atrial systolic performance in hypertrophic cardiomyopathy.


Influence of ageing on left atrial appendage flow velocity pattern in healthy subjects with sinus rhythm: a study with transesophageal pulsed Doppler echocardiography.


Influence of left atrial pressure on the left atrial appendage flow velocity pattern in myocardial diseases with sinus rhythm.


非代償性肝硬変患者に対する肝不全用成分栄養剤ヘパンEDの腹水，脳症および臨床検査値改善効果に関する検討


徳島県における消化性潰瘍治療の現況 --- レバミピド併用療法オープン試験とアンケート調査結果を解析して


大量下血をきたした空腸平滑筋腫の1例

大量下血をきたした空腸平滑筋腫の1例


各種画像診断にて肝癌と鑑別困難であった肝内多発結節性病変の1例

各種画像診断にて肝癌と鑑別困難であった肝内多発結節性病変の1例


輸血後肝炎におけるHCV抗体陰性例の実態

輸血後肝炎におけるHCV抗体陰性例の実態


慢性肝疾患における検査と治療

慢性肝疾患における検査と治療

日本臨床化学会四国支部会誌

日本臨床化学会四国支部会誌


肝硬変患者腹水中の蛋白合成刺激活性

肝硬変患者腹水中の蛋白合成刺激活性

Japanese Journal of Medicine and Pharmaceutical Science


C型肝炎のIFN療法における精神的副作用について

C型肝炎のIFN療法における精神的副作用について


The Japanese journal of clinical and experimental medicine


十二指腸液逆流にもとづく実験的逆流性食道炎の実験モデル作成法

十二指腸液逆流にもとづく実験的逆流性食道炎の実験モデル作成法


H2ブロッカー抵抗性潰瘍

H2ブロッカー抵抗性潰瘍


γ-グルタミルトランスペプチダーゼ(γ-GTP)

γ-グルタミルトランスペプチダーゼ(γ-GTP)


型肝炎のIFN療法における短期副作用(特に白血球数，好中球数および血小板数)について


揚子江下流域肝癌多発地区における肝疾患の特性とHCV

揚子江下流域肝癌多発地区における肝疾患の特性とHCV


HCV (C100-3) 抗体スクリーニング後の輸血後肝炎について

HCV (C100-3) 抗体スクリーニング後の輸血後肝炎について


ラット実験的逆流性食道炎モデルの成因について

ラット実験的逆流性食道炎モデルの成因について


HCV抗体測定の問題点と将来

HCV抗体測定の問題点と将来


食道静脈瘤硬化療法が有効であった巨木型食道静脈瘤(pipeline varix)の1例


実験的急性膵炎における血中ブラデイキニンの動態に関する研究

実験的急性膵炎における血中ブラデイキニンの動態に関する研究


十二指腸と空腸に多発した平滑筋腫の1例．

十二指腸と空腸に多発した平滑筋腫の1例．


Guanaseの免疫組織化学的研究 --- 特に Western blotting法によるguanase抗体の検討


H2ブロッカ-使用例における潰瘍底の隆起について --- 特に隆起型潰瘍瘢痕と白色隆起の差異


Peroxidase 標識抗体を用いたguanaseの免疫組織化学染色法

Peroxidase 標識抗体を用いたguanaseの免疫組織化学染色法


逆流性食道炎に対する塩酸ロキサチジンアセタートの1日1回150mg就寝前投与による臨床効果


Guanaseの電顕組織化学的証明法

Guanaseの電顕組織化学的証明法

Journal of Clinical and Experimental Medicine


隆起性胃潰瘍瘢痕の検討 --- 特にcimetidine 使用例について

隆起性胃潰瘍瘢痕の検討 --- 特にcimetidine 使用例について


第30回 四国肝臓研究会

第30回 四国肝臓研究会


Surveillance and the Approach for the Proper Use of Antibiotics at Tokushima University Hospital

徳島大学医学部附属病院における抗菌薬適正使用の取り組みと使用状況

The working committee for the proper use of antibiotics was organized at Tokushima University Hospital in March 2002, and the institutional guidelines for the selection and use of antibiotics were established. The infection control team (ICT) also started monitoring the use of particular antibiotics, including third- and fourthgeneration cephalosporins, calbapenems and anti-MRSA antibiotics, and reported on their use in August 2002. To assess these activities, we examined the status of antibiotic use for injections and compared our findings with the previous data. The results were as follows : 1) the reports required were presented in 47% of the total antibiotics used ; 2) after starting the surveillance, the use of the third- and fourth-generation cephalosporins and calbapenems shifted to the first- and second-generation drugs, while the use of anti-MRSA drugs clearly decreased ; 3) these changes resulted in a savings of more than two million yen in medical expenditures in a month. These results suggest that closely monitoring the use of antibiotics may thus be beneficial not only for promoting the proper use of antibiotics but also for reducing overall medical costs.

Japanese Journal of Pharmaceutical Health Care and Sciences


肝細胞アポトーシスにおけるエストラジオールとエストロゲン受容体βの抑制的関与

肝細胞アポトーシスにおけるエストラジオールとエストロゲン受容体βの抑制的関与


コリンエステラーゼについて

コリンエステラーゼについて


脂質過酸化反応と肝繊維化

脂質過酸化反応と肝繊維化