type: misc

label: url

en: 【薬物選択の論点】 抗ウイルス薬

ja: 【薬物選択の論点】 抗ウイルス薬

en: Ophthalmology

ja: 眼科


en: 【中毒と眼】 各種内服薬と眼の副作用

ja: 【中毒と眼】 各種内服薬と眼の副作用


en: Medical significance of cysteine protease inhibitors in mammalian secretory fluids

en: New cysteine protease inhibitors in human tears and milk and their medical significance are reviewed in this paper. As protective components against bacterial infection in the eyes, we detected four kinds of anti-bacterial proteins in normal human tears including lysozyme and three kinds of cysteine protease inhibitors. Using our reverse zymography of normal tears, three kinds of cysteine protease inhibitors were found to be 78kDa, 20kDa and 15kDa and were determined to be lactoferrin, Von Ebner's Gland (VEG) protein and cystatin S, respectively. All of them belong to the cystatin super family and VEG protein and cystatin S are well known cysteine protease inhibitors. The C-terminus area 17mer peptide, Y679-K695, of lactoferrin showed strong homology with a common active domain of the cystatin family and the synthesized peptide showed inhibition of cysteine proteases. Not only were disease-specific changes found in these inhibitor profiles, but also disease-specific new inhibitors in patients tears with certain autoimmune diseases. A 35kDa inhibitor, which was detected specifically in tears with Behcet's disease, an typical autoimmune disease, was determined to be a lacrimal acidic proline-rich protein based on the N-terminus sequence analysis. A 65kDa inhibitor of tears with Harada's autoimmune disease was determined to be an Ig heavy chain V-III region. In addition, lactoferrin content in Harada's disease was very low. We found two cathepsin inhibitors in bovine milk using reverse zymography, namely lactoferrin and beta-casein. The L133-Q151, in the human beta-casein molecule is the active inhibitory domain. They may play an important role in antiseptic and anti-infectious functions.

en: The Journal of Medical Investigation : JMI


en: 【ウイルス性眼疾患の診療】 ウイルス感染症の治療 抗ウイルス薬の種類

ja: 【ウイルス性眼疾患の診療】 ウイルス感染症の治療 抗ウイルス薬の種類

en: 眼科診療プラクティス

ja: 眼科診療プラクティス


en: アカントアメーバ角膜炎とその治療方法について教えて下さい

ja: アカントアメーバ角膜炎とその治療方法について教えて下さい

en: Journal of the Eye

ja: あたらしい眼科


en: ヘルペス性角膜炎

ja: ヘルペス性角膜炎

en: The Japanese journal of clinical and experimental medicine

ja: 臨床と研究