Reproducibility of Metabolite Concentration Evaluated by Intraclass Correlation Coefficient Using Clinical MR Apparatus.

The purpose of this study was to evaluate the reproducibility of in vivo quantitative proton MR spectroscopy (MRS) by repeated-measure analysis of variance and intraclass correlation coefficient (ICC) including assessment of both inter- and intrasubject variation. The concentration of metabolites was quantified using long-TR and short-TE stimulated-echo acquisition mode sequences with a quadrature head coil. All preparation procedures for MRS measurement except volume of interest determination were done by an automatic preparation scanning system equivalent to a clinical setting. Analyses were conducted by an LCModel running based on our original basis set by two different reference methods. The ICC showed a good correlation (r = 0.61-0.99) in any metabolite and almost the same value between the two different reference methods, but the concentration of myoinositol had a large intersubject variation. Our results suggest that the reproducibility of quantified metabolite concentration is acceptable in the clinical setting regardless of the reference method, although quantified values may have different intersubject variations.


新構想徳島大学医学部歯学部附属病院におけるHIS,RIS,PACS-モダリティ連携と歯科放射線科


Insufficiency fractures following radiation therapy for gynecologic malignancies

The Official Jpurnal of The Japanese Society for Therapeutic Radiology and Oncology


A characteristic feature of acute haematomas in the brain on echo-planar diffusion-weighted imaging

Diffusion-weighted MRI (DWI) is used in the diagnosis of acute ischaemic disease of the brain, but it is not clear whether or not it can be used to differentiate an acute haematoma from an infarct. Our purpose was to identify any characteristic feature of acute haematomas which can be recognised on DWI and to evaluate the usefulness of DWI in acute cerebral stroke. We examined nine patients with acute haemorrhage using CT and MRI including DWI. We measured the volume and apparent diffusion coefficient (ADC) of the haematomas. All showed heterogeneous signal on DWI, and the centre of the large (>20 ml) haematomas especially a mixed pattern with high and low signal. The characteristic feature of acute haematomas was a peripheral low-signal region, found in all subjects regardless of the size of the haematoma; acute infarcts did not show this. This low-signal rim on DWI may be useful for differentiating an acute haematoma from an infarct.


X線により発色をする反射型フィルム素材を用いたIVR手技時の患者皮膚線量測定

X線により発色をする反射型フィルム素材を用いたIVR手技時の患者皮膚線量測定

Japanese Journal of Radiological Technology


Diffusion-weighted in vivo localized proton MR spectroscopy of human cerebral ischemia and tumor

The apparent diffusion coefficients (ADCs) of water and brain metabolites were determined by proton MR spectroscopy on a clinical MR scanner for healthy volunteers and for pathological changes in cases of acute cerebral infarction and brain tumor. The ADCs of N-acetyl aspartate (NAA) and creatines in tissue involved in acute infarction were decreased compared to normal control values, while in tumors they showed increased values. Since NAA is a neuronal marker, these findings suggest that neuronal cell viscosity changes according to the pathological status of the tissue. The lactate ADC was significantly larger than the values for other major metabolites in cases of ischemia and tumor, suggesting that lactate is present in a different compartment. These results indicate that metabolite diffusion data can be used to reveal changes in the intracellular environment depending on the pathological status.


強迫性障害におけるproton MRSによる評価 --- 特にグルタミン酸とグルタミン代謝に対して

Japanese Journal of Magnetic Resonance in Medicine


Huang, L., Ogushi, F., Tani, K., Ogawa, H., Kawano, T., Endo, T., Izumi, K., Ueno, J., Nishitani, H. and Sone, S. Thrombin Promotes Fibroblast Proliferation during the Early Stages of Experimental Radiation Pneumonitis. Radiat. Res. 156, 45-52 (2001). To clarify the role of thrombin in the pathogenesis of radiation-induced pneumonitis, we measured the thrombin activity and fibroblast growth-inducing activity in bronchoalveolar lavage fluid obtained from the irradiated lungs of rats at 1, 2, 4, 8 and 18 weeks after irradiation. Thrombin activity was not detected in the bronchoalveolar lavage fluid from unirradiated rats, but the bronchoalveolar lavage fluid from irradiated rats showed significantly increased thrombin activity which reached a maximum at 4 weeks after treatment. Higher fibroblast growth-inducing activity was detected in the bronchoalveolar lavage fluid from irradiated rats at 4 and 18 weeks than in fluid from unirradiated rats. Bronchoalveolar lavage fluid from irradiated rats that were pretreated with the thrombin inhibitors antithrombin III and argatroban showed significantly inhibited fibroblast growth-inducing activity and thrombin activity at 4 weeks. However, these thrombin inhibitors did not inhibit fibroblast growth-inducing activity in bronchoalveolar lavage fluid from irradiated rats at 18 weeks. Purified rat thrombin similarly induced proliferation of fibroblasts derived from irradiated and unirradiated rats. These findings suggest that thrombin may play an important role as a fibroblast growth-inducing factor during the early stages of radiation pneumonitis.


Multivariate analysis of regional metabolic differences in normal ageing on localised quantitative proton MR spectroscopy


Evaluation of female intrapelvic tumors by clinical proton MR spectroscopy.

We measured metabolites in large tumors of the female pelvis (23 cases total: 6 malignant cases, 17 benign cases) using single-voxel proton magnetic resonance (MR) spectroscopy and evaluated the clinical significance of this method in the differential diagnosis of female pelvic tumors. The characteristically obtained signal was lactate, which was detected not only in all the malignant tumors but also in some of the benign tumors. However, the lactate signals of the malignant tumors tended to form higher peaks than those of benign tumors, which was a finding consistent with the result of the earlier in vitro study reported in ovarian tumors. The signal of choline-containing compounds (Cho) was found only in solid tumors, and the signal intensity varied among different histological types of tumors, possibly reflecting metabolic activity of the cell membrane. We considered that proton MR spectroscopy (MRS) of intrapelvic tumors would be useful for the diagnosis of the nature of female intrapelvic tumors. J. Magn. Reson. Imaging 2001;13:912-917.

Journal of Magnetic Resonance Imaging : JMRI


拡散強調画像で過小評価された急性期脳梗塞の2例

拡散強調画像で過小評価された急性期脳梗塞の2例


摂食による冠動脈血流速度の変化，胃電図および冠動脈シネMRAを用いた検討

摂食による冠動脈血流速度の変化，胃電図および冠動脈シネMRAを用いた検討


99mTc-MIBIによる運動負荷時冠血流増加率と冠動脈血流速波形との関連 --- -冠動脈MR coronary angiographyを用いた検討-


The Effects of Inhomogeneities on MCG forward Solution

高精度な胸部磁界の逆問題解法について述べた．これは胸部画像から胸部実形状モデルを得て磁気信号源が存在する胸部領域をMUSIC法で解析する手法を示し，この手法が分布型磁気信号源モデルの推定に期待できることを示した．

IEICE Transactions on Information and Systems


Clinical Investigation of Accumulation Process of 99mTc-HMDP and -MDP in Bone

99m-Tc-HMDPおよび-MDPの骨への集積過程の臨床的研究


脳卒中急性期における画像診断プロトコール

脳卒中急性期における画像診断プロトコール


A comparison of the results of radiotherapy and surgical treatment of tangue cancer

The Official Jpurnal of The Japanese Society for Therapeutic Radiology and Oncology


Evaluation of multi-vendor PACS in the wards --- performance and users' behavior


Overexpression of wild-type Akt1 promoted insulin-stimulated p70S6 kinase (p70S6K) activity and affected GSK3 beta regulation, but did not promote insulin-stimulated GLUT4 translocation or glucose transport in L6 myotubes.

We have developed a simple, direct and sensitive method to detect GLUT4 on the cell surface. Using this system, we found that PI3-kinase plays a key role in the signaling pathway of insulin-stimulated GLUT4 translocation. One of the down stream effectors of PI3-kinase is serine-threonine kinase Akt (protein kinase B, RAK-PK), but the involvement of Akt in insulin-stimulated GLUT4 translocation is controversial. To investigate whether Akt1 regulates insulin-stimulated GLUT4 translocation and glucose uptake in L6 myotubes, we established L6 myotubes stably expressing c-myc epitope-tagged GLUT4 (GLUT4myc) and mouse wild type (WT) Akt1. We found that overexpression of WT Akt1 promoted insulin-stimulated p70S6 kinase (p70S6K) activity and increased the basal activity of GSK3 beta, but did not promote insulin-stimulated GLUT4 translocation or glucose uptake. These data supported the result that Akt is not a main signaling molecule to transmit the signal of insulin-stimulated GLUT4 translocation or glucose uptake from insulin-activated PI3-kinase.

The Journal of Medical Investigation : JMI


Neuronal impairment of adult moyamoya disease detected by quantified proton MRS and comarison with cerebral perfusion by SPECT with Tc-99m HM-PAO: A trial of clinical quantification of metabolites

We evaluated neuronal impairment of adult moyamoya patients by proton magnetic resonance spectroscopy (MRS) and cerebral perfusion scintigraphy. After evaluating two methods for compensating relaxation times, we selected a long TR, short TE sequence to achieve better reproducibility. The cerebral blood flow (CBF) value was measured by scintigraphy following the method of quantification reported in the previous literature. N-acetyl aspartate (NAA) concentrations and CBFs value were decreased statistically (P < 0. 05) compared with those of the age-matched normal controls. However, the decreased rate of NAA concentration was changed more than the CBF value, and no linear correlation was found between the two values. We considered that the NAA concentration was not always correlated with that of the present cerebral perfusion. The NAA concentration showed a more dispersive distribution in patients than in controls, indicating a large individual variation in neuronal impairment. We concluded that proton MRS may provide useful information about neuronal impairment in individual patients. J. Magn. Reson Imaging 1999;10:124-129.


Brain metabolites in the hippocampus-amygdala region and cerebellum in autism: an 1H-MR spectroscopy study.

Histological abnormalities of the brain in autism have been investigated extensively. We studied metabolites in the hippocampus-amygdala (HA) region and cerebellum. We examined the right HA region and left cerebellar hemisphere of 27 autistic patients 2-18 years old, 21 boys and 6 girls and 10 normal children 6-14 years old, 4 boys and 6 girls, using the STEAM sequence. This sequence was used to minimise the influence of relaxation times. The N-acetyl aspartate (NAA) concentration was significantly lower (P = 0.042) in autistic patients than in normal children (9.37 and 10.95 mM, respectively). There was no significant difference in other metabolites. The correlation coefficient (r value) of NAA between the HA region and cerebellum was 0.616. The decreased NAA concentration may be due to neuronal hypofunction or immature neurons. The NAA concentration in the HA region and cerebellum may be related, because of neuronal circuits or networks.


Radiotherapy for Carcinoma of the Uterine Cervix using Low-Dose-Rate Intercavitary Brachytherapy- A Retrospective Analysis of Pretreatment and Treatment Prognostic Factore-


Effects of hepatic impairment on the metabolism of fructose and 5-fluorouracil, as studied in fatty liver models using in vivo 31P-MRS and 19F-MRS.

The purpose of this study was to observe the effects of hepatic impairment on the metabolism of fructose and 5-fluorouracil (5-FU) in fatty liver models using in vivo 31P-MRS and 19F-MRS and to compare the results. In addition, we compared the results to those of other conventional tests such as laboratory examinations, imaging and pathology. Male SIc:Wistar rats were examined on BEM170/200 (4.7 T, Otsuka Electronics, USA) with 17-mm diameter surface coil. Fatty liver was induced by a choline deficient diet (CD diet) for 2 weeks. 31P-MRS were obtained for 90 min after intravenous (i.v.) injection of 1 g/kg of fructose and 19F-MRS were measured for 100 min after i.v. injection of 100 mg/kg of 5-FU. 1H-MRS and 1H-MRI were also performed. On 31P-MRS, there was no statistical difference in the time course of phosphomonoester (PME), adenosine triphosphate (ATP), and inorganic phosphate (Pi) between CD diet group and control group. On 19F-MRS, we detected high peak of fluoronucleotide (Fnct) and suppressed peak of alpha-fluoro-beta-alanine (FBAL) in CD diet group. We showed the metabolism of fructose and 5-FU by 31P-MRS and 19F-MRS, respectively. There was no difference in fructose metabolism but we observed increased fluoronucleotide and decreased a-fluoro-b-alanine in 5-FU metabolism of fatty liver. We speculate that the effects of hepatic impairment in fatty liver may be more severe on 5-FU metabolism and the increased fluoronucleotide may reflect cell proliferation.


Radiation Complications Following Breast Conserving Therapy


Segmentation of Sputum Color Image for Lung Cancer Diagnosis Based on Neural Networks

高性能喀痰自動細胞診システムの開発を目指している．このために喀痰画像から肺がん細胞を検出するために細胞画像から肺がん細胞をセグメンテーションする手法を述べた．その実験結果を示した．


Segmentation of sputum color image for lung cancer diagnosis based on neural networks

IEICE Transactions on Information and Systems


回転デジタルX線撮影装置を用いたコーンビームC --- 肺野および骨病変に対する初期臨床経験


Radioimmunodetection of human myeloma xenografts with a monoclonal antibody directed against a plasma cell specific antigen, HM1.24


Three dimensional solid model reconstruction for neurosurgical approach.


MRIによる冠動脈血流速度

MRIによる冠動脈血流速度


Coronary-Pulmonary Artery Fistulae Depicted by Multiplanar Reconstruction Using Magnetic Resonance Imaging


Proton MR SPectroscopyの定量化における基礎的検討と慢性脳虚血性疾患に対する応用


Proton MRSにおける脳内代謝物の横緩和時間について-定量化に関わる要因として-


Hopfield neural network for the multichannel segmentation of magnetic resonance cerebral images

改良ポップフィ-ルドネットワ-クを用いてマルチスペクトルMR画像を高精度にセグメンテ-ションする手法を述べた．改良ポップフィ-ルドネットワ-クは従来法と比較して高速で高品質なセグメント結果を得ていることを示した．


Influence of copper on MRI of hepatocellular carcinoma.

The purpose of this paper is to clarify whether copper accumulation in hepatocellular carcinoma (HCC) is a cause of high intensity signal pattern on T1-weighted images (T1-WI) by comparing the histologically proven copper accumulation with MR images. Forty-five surgically resected HCCs were analyzed. Distribution patterns of divalent copper by a modified Timm's method on their maximum cut surfaces were compared with signal patterns on corresponding T1-WI. The degree of copper accumulation in tumor compared with surrounding liver tissue was higher in 6 lesions, equal in 17 lesions, and lower in 22 lesions. High intensity pattern on T1-WI were observed in 3 of 6 lesions (50%), 10 of 17 lesions (59%), and 10 of 22 lesions (45%). Distribution patterns of copper were not correlated with intensity patterns on T1-WI. We conclude that the paramagnetic effect of divalent copper accumulation in HCC is insufficient to influence the MRI.

Journal of Magnetic Resonance Imaging : JMRI


Carcinoma of the Uterine Cervix with Myocardial Metastasis


Complexities encountered in reconstructing 3D images of sellar and parasellar lesions from CT data for surgical planning


A comparison of hopfield neural network and boltzmann machine in segmenting MR images

MR画像のセグメンテ-ションに関して我々が改良したホップフィ-ルドネットワ-クと一般的なボルツマンマシンを比較評価した．その結果，改良ホップフィ-ルドネットワ-クがボルツマンマシンと比べて処理速度·セグメント精度ともに好結果であることを示した．


Segmentation of brain MR images based on neural networks

改良ポップフィ-ルドネットワ-クを用いたマルチスペクトルMR画像のセグメンテ-ション法を述べた．評価関数や準最適化解を得る高速収束アルゴリズムを示し，その実行結果を専門医との比較評価をして高精度であることを示した．

IEICE Transactions on Information and Systems


Therpeutic Efficacy of A Case of Pyruvate Dehydrogenase Complex Deficiency Monitored by Localized Proton Magnetic Resonance Imaging


新オルソシステムを用いた被曝線量低減の検討(3) --- Kodak Insight EF/RA Imaging Systemについての検討


Undergraduate Radiology Education Utilizing WWW Server-Client System


Multimedia Based Teaching File for Radiological Cases Diagnosed with 3D Images and Models from CT and MR Modalities


Ectopic Gastric Mucosa in the Upper Esophagus --- Prevalence and Radiologic Findings


Non-invasive Characterization of Brain Tumor by in-vivo Proton Magnetic Resonance Spectroscopy


Brain Asbcess Observed by Localized Proton Magnetic Resonance Spectroscopy


Diagnostic Ability of Computer Recreated Images of Pathological Lesions of the Alimentary System

Computer Applicatons to Assist Radiology


Ectopic Gastric Mucosa in the Upper Esophagus --- Detection and Radiographic Findings


Noninvasive localization of accessory pathways by magnetocardiographic imaging

The magnetocardiogram (MCG) is a newly developed method that helps localize a cardiac current source. To test the clinical accuracy of a 7-channel biomagnetic system in the localization of early ventricular depolarization sites, the MCGs of 14 patients with Wolff-Parkinson-White (WPW) syndrome were recorded in a radiofrequency-shielded room. The locations of early ventricular depolarization sites were classified by standard 12-lead electrocardiograms (ECGs) and body surface isopotential mapping. The accessory pathways of 3 patients with WPW syndrome were located in the right free wall and in 11 patients in the left free wall. The three-dimensional (3-D) dipole location was computed every 2 ms from the onset of the QRS complex by the least-square method. These 3-D dipole locations were projected onto a gated magnetic resonance image in order to visualize the propagation of the calculated ventricular source. The results were compared with those obtained by body surface isopotential mapping, and electrocardiographic and electrophysiologic studies. The location of the deduced current dipole at 20 ms correlated well with the location of the accessory pathway by the body surface mappings in 12 of the 14 patients with WPW syndrome. The MCG is capable of precisely determining the 3-D location of a current source in a noninvasive manner and may be of potential benefit in the treatment of WPW syndrome by catheter ablation.


Prediction of the site of origin of ventricular premature beat by magnetocardiogram

心臓磁界測定による心室性期外収縮の心室最早期興奮部位の推定

心磁図による診断法を確立するために，生体内の電流源を三次元的に推定する心磁図法と，心電図同期MRI断層法を併用して，心室性期外収縮発生源の位置を推定した．推定された値は，体表面電位図法から推定される発生源とほぼ一致し，診断学的にも有用であることがわかった．


心磁図法によるQRS初期ベクトルの位置推定‐MRI画像上への表示

心磁図法によるQRS初期ベクトルの位置推定‐MRI画像上への表示


7チャンネルSQUID磁束計による心臓磁界計測およびdipoleの位置推定

7チャンネルSQUID磁束計による心臓磁界計測およびdipoleの位置推定


Accuracy of the results measured by in vivo 1H-MRS using model solution

The Tokushima Journal of Experimental Medicine


正常例の初期QRS波のdipoleの位置推定‐心電図同期MRI画像上への表示‐

正常例の初期QRS波のdipoleの位置推定‐心電図同期MRI画像上への表示‐

The Journal of Japan Biomagnetism and Bioelectromagnetics Society


心磁図法による心室最早期興奮部位の推定‐磁界分布図と体表面電位図·心表面マッピングとの対比‐


A study of skeletal metastasis of Carcinoma of the Uterine Cervix

子宮頸癌の骨転移例の検討

The Official Jpurnal of The Japanese Society for Therapeutic Radiology and Oncology


Eight Cases of Intracranial Arteriovenous Malformations Conducted Conventional Radiation Therapy

放射線療法を行った頭蓋内動静脈奇形について


Measurement of left atrial volume curve by advanced 2D tissue tracking technique: validation by contrast multidetector computed tomography.

Journal of the American Society of Echocardiography


MDCTのボリュームデータを用いた肺結節の検出法の検討

MDCTのボリュームデータを用いた肺結節の検出法の検討

The purpose of this study is to determine if combination of adequate postprocessing techniques and thin section image data from MDCT could improve the accuracy of detection of lung nodules. Readers' performance for the nodule detection was evaluated by ROC analysis. The combination of postprocessing techniques (STS-MIP or STS-VR) using thin section image data from MDCT improved the accuracy of detection of lung nodules significantly. There is no statistically significant difference in the detectability of lung nodules between the scrolling through thin section images and the scrolling through thick section images.

MDCTで撮像された胸部CTにおいて肺野の小結節を対象に，その存在診断における薄いスライス厚のボリュームデータの有効な利用観察方法について検討した．Thick section (10mm)，thin section (1mm)のaxial像および15mmスラブ厚でのインタラクティブなスライディングを用いたMIP法とVR法で検出能の違いを比較するための読影実験を行い，ROC解析を用い検討した．MIP法やVR法での観察が有用であり，thin sectionのみの観察では検出能は向上しなかった．


Assessment of early diastolic left ventricular regional myocardial function in patients with hypertrophic cardiomyopathy using tissue Doppler imaging and magnetic resonance myocardial tagging.


機能性磁気共鳴画像(FMRI)法を用いた視覚神経系の賦活に関する基礎的検討

機能性磁気共鳴画像(FMRI)法を用いた視覚神経系の賦活に関する基礎的検討

Bulletin of School of Medical Sciences, the University of Tokushima

徳島大学医療技術短期大学部紀要


水溶性高分子で構造化した水に溶解した代謝物質の緩和時間変化

水溶性高分子で構造化した水に溶解した代謝物質の緩和時間変化

徳島大学医療技術短期大学部紀要


1H-MRSによる脳内代謝物質の内部標準としての水の有用性

1H-MRSによる脳内代謝物質の内部標準としての水の有用性

徳島大学医療技術短期大学部紀要


モデル溶液中の脳内代謝物質と水の緩和時間の基礎的検討

モデル溶液中の脳内代謝物質と水の緩和時間の基礎的検討

徳島大学医療技術短期大学部紀要


脳運動野における機能性MRIの基礎的検討

脳運動野における機能性MRIの基礎的検討

徳島大学医療技術短期大学部紀要


Three Dimensional Dissection View of the Urinary Bladder

International Journal of Computer Assisted Radiology and Surgery


1H-MRスペクトロスコピーによる脳内代謝物質の検討

1H-MRスペクトロスコピーによる脳内代謝物質の検討

徳島大学医療技術短期大学部紀要


オムニパークの有用性に関する徳島地区多施設共同研究

オムニパークの有用性に関する徳島地区多施設共同研究


点滴静注尿路造影におけるイオパミロン150の使用経験

点滴静注尿路造影におけるイオパミロン150の使用経験

The Japanese journal of clinical and experimental medicine


Detecting Lung Cancer Symptoms with Analogic CNN Algorithms Based on a Constrained Diffusion Template

In this article, a new type of diffusion template and an analogic CNN algorithm using this diffusion template for detecting some lung cancer symptoms in X-ray films are proposed. The performance of the diffusion template is investigated and our CNN algorithm is verified to detect some key lung cancer symptoms, successfully.

本研究では，新しいタイプの拡散テンプレートと，その拡散テンプレートを利用したX線画像の肺癌部分検出セルラ·ニューラル·ネットワークのアルゴリズムを提案している．拡散テンプレートの特徴を詳細に調査し，さらに，本手法が肺癌部分を効果的に抽出できることを確認している．

IEICE Transactions on Fundamentals of Electronics, Communications and Computer Sciences


Proton MRSにおける脳内代謝物の横緩和時間について-定量化に関わる要因として-


A case of recurrent Squamous Cell Carcinoma of Cervix successfully treated with BOMP

癌性心膜炎，癌性腹膜炎に対する全身BOMP療法が奏効した再発子宮頸癌の1例

Japanese Journal of Cancer and Chemotherapy


An Anal Cancer that responded to Chemoradiotherapy A case report

化学放射線併用療法にて組織学的にCRとなった肛門癌の1症例


Eosinophilic Granuloma in Hypothalamus and Pituitary Gland ; A case report of effective Radiation Therapy

視床下部ー下垂体原発好酸球肉芽腫の放射線治療著効例