Role of the flocculus in the development of vestibular compensation: Immunohistochemical studies with retrograde tracing and flocculectomy using Fos expression as a marker in the rat brainstem


めまいに対するアメジニウムの効果

めまいに対するアメジニウムの効果


良性発作性頭位めまい症の臨床的検討と耳石器機能

良性発作性頭位めまい症の臨床的検討と耳石器機能


A ground-based animal model of space adaptation syndrome


Molecular cloning of the rat NADH:ubiquinone oxidoreductase subunit and its up-regulation in the facial muscle after denervation: detected by means of differential display

The differential display method was applied to identify gene expression which is especially up-regulated in the rat denervated skeletal muscle. Total RNA from normal and denervated facial muscles was isolated, amplified by PCR using certain primers, and separated by electrophoresis on polyacrylamide gel. PCR products which were apparently higher in the operated than in the control side were cut out from the gel and subsequently sequenced. One of the cDNA fragments obtained in the present study showed about 80% identity in nucleotide sequence and about 84% identity in amino acid sequence to one of the NADH: ubiquinone oxidoreductase (complex I) subunits from the bovine heart mitochondria (813). Complex I, the first and largest enzyme of the mitochondrial respiratory chain, transfers electrons from NADH to ubiquinone-10 (UQ-10). B13 is a 13 kDa subunit; deficiency of which causes incomplete or incorrect assembly of a functional complex I, resulting in one of the types of human mitochondrial myopathy. Northern blot analysis and in situ hybridization histochemistry confirmed that rat B13 mRNA expression was up-regulated after denervation and was distributed throughout whole muscle cell body. These findings suggest that up-regulation of the rat B13 mRNA expression after denervation plays an important role in the effective electron transfer from NADH to UQ-10 in skeletal muscle cells, resulting in restriction of lipid peroxidation and biological tissue damage.


鼓室形成術III型変法の手術成績

鼓室形成術III型変法の手術成績

Hearing results of 130 ears operated on by type III tympanoplasty were reviewed. Postoperative air-bone gap was less than 10dB in 70 ears (53.8%) and less than 20dB in 105 ears (80.8%). There was no statistical difference in hearing results between chronic middle otitis with and without cholesteatoma. There was statistical difference in mean postoperative air-bone gap between the cases used ossicles and the cases used cortical temporal bone chips (Post-hoc test, p<0.05).


GABAergic inhibitory response of locus coeruleus neurons to caloric vestibular stimulation in rats


Effects of caloric vestibular stimulation on parietal and temporal blood flow in human brain: a consecutive technetium-99m-HMPAO spect study


Effects of caloric vestibular stimulation on prepositus hypoglossi neurons in rats

European Archives of Oto-Rhino-Laryngology


突発性難聴の治療法による群間検定

突発性難聴の治療法による群間検定


垂直半規管刺激性回転後眼振 --- 健常耳での外側半規管刺激との比較

垂直半規管刺激性回転後眼振 --- 健常耳での外側半規管刺激との比較


聴力正常の小脳橋角部大腫瘍の2症例

聴力正常の小脳橋角部大腫瘍の2症例


起立生低血圧によるめまい症の1例 --- 椎骨動脈血流の左右差と眼振との関係

起立生低血圧によるめまい症の1例 --- 椎骨動脈血流の左右差と眼振との関係


前庭皮質と前庭失認に関する臨床的検討

前庭皮質と前庭失認に関する臨床的検討


両側および一側レルモワイエ症候群症例と発症機序に関する考察

両側および一側レルモワイエ症候群症例と発症機序に関する考察


Hearing results of 51 ears with tympnaosclerosis were reviewed. Postoperative air-bone gap was less than 10dB in 34 ears (66.7%) and less than 20dB in 46 ears (90.2%). There was no statistical difference in hearing results between type I and type III tympanoplasty. There was statistical difference in hearing results between the eras with and without tympanosclerosis of the stapes. In cases of stapes fixation, the ears with stapedectomy tended to have better hearing results than those without stapedectomy. But there were only 7 ears of tympanosclerosis of stapes, and the experince is needed to further discuss whether stapedectomy is useful or not.


Neuropharmacological mechanisms of emesis. II. Effects of antiemetic drugs on cisplatin-induced pica in rats

Methods and Findings in Experimental and Clinical Pharmacology


Effects of MK801 on Fos expression in the rat brainstem after unilateral labyrinthectomy


Up-regulation of ferritin heavy chain mRNA expression in the rat skeletal muscle after denervation: detected by means of differential display


Neuropharmacological mechanisms of emesis. I. Effects of antiemetic drugs on motion- and apomorphine-induced pica in rats


Serotonin 5HT3-Recepter Antagonist for Cisplatin-Induced Nausea and Vomiting

CDDP嘔吐に対する坑セロトニン薬の効果


Assessment of auditory and vestibular functions after vestibular neurectomy for Meniere's disease

Fourteen patients (12 Meniere's disease, one delayed endolymphatic hydrops and one labyrinthitis) suffering from intractable vertigo were treated with retrosigmoid vestibular neurectomy (RSVN) in our institute. Dizziness was controlled completely in all patients. Hearing was preserved in 91.7% of the cases with pure tone threshold deteriorating by more than 10 dB in one case, remained unchanged in 10 cases and improved in one case during long term observation. Substantial decrease of tinnitus was observed in 78.6%. Vestibular compensation was chronologically analyzed with a stabilometer, ENG and vestibular rotation test (0.01-0.64 Hz). Vestibular compensation under static conditions was accomplished within 2 weeks, except for spontaneous nystagmus measured in the dark. Asymmetry of vestibulo-ocular reflex was noted 2 weeks after the operation but had disappeared after 4 weeks. However, for over 2 years the VOR time constant remained lower (4.3-5.2 s) than the pre-operative value (8.2 s). Electro-cochleogram (ECoG) was recorded before and after RSVN. The -SP/AP ratio tended to increase after RSVN in the operated ear, though there was no change in the contralateral ear. The efferent olivo-cochlear bundle was thought to play a potential role in this increase of the -SP/AP ratio.


めまい患者の日常生活支障度 --- 多変量解析を用いた評価

めまい患者の日常生活支障度 --- 多変量解析を用いた評価


前庭神経炎の診断および治療における問題点 --- 突発性めまい症例の臨床的検討からの考察


Gene regulation of cyclic amp-dependent protein kinase subunits (Cα,β; RIα, β and RIIα,β) in rat facial motoneurons after nerve transection


Up-regulation of GAP-43 (B50/F1) gene expression in vestibular efferent neurons following labyrinthectomy in the rat: In situ hybridization using an alkaline phosphatase-labeled probe


Effects of vestibular stimulation on acetylcholine release from rat hippocampus: an in vivo microdialysis study

1. The effects of electrical stimulation to the round window of the inner ear and caloric vestibular stimulation on the in vivo release of acetylcholine (ACh) from rat hippocampus were investigated, using brain microdialysis coupled with high performance liquid chromatography-electrochemical detection. 2. Hippocampal ACh release was increased to 152% of the basal release by 1-Hz, 200-ms, and 500-microA electrical stimulation to the round window. This effect was dependent on current intensity. 3. Microinjection of 6,7-dinitroquinoxaline-2,3-dione (DNQX) (10 nmol/0.2 microliter), an antagonist of the non-N-methyl-D-aspartate (non-NMDA) type of glutamate receptor, into the medial vestibular nucleus blocked the increase of hippocampal ACh release by electrical stimulation to the round window. In contrast, microinjection of DNQX (10 nmol/0.2 microliter) into the ventral cochlear nucleus did not inhibit the increase of hippocampal ACh release by electrical stimulation to the round window. 4. Electrical stimulation of the round window increased histamine release from the medial septum, which is the origin of the hippocampal cholinergic terminals. However, the depletion of neuronal histamine by alpha-fluoromethylhistidine (100 mg/kg ip) did not suppress the vestibular-evoked release of hippocampal ACh. 5. Although caloric stimulation with water at 37 degrees C did not affect the hippocampal ACh release, the release was increased to 131% of the basal release by caloric stimulation with hot water at 45 degrees C and was also increased to 160% of the basal release by caloric stimulation with ice water, suggesting that the changes in activities of vestibular afferents increased the hippocampal ACh release.(ABSTRACT TRUNCATED AT 400 WORDS)


Expression of GABAA receptor γ1 and γ2 subunits in the peripheral vestibular system of the rat


Occurrence of galanin-like immunoreactivity in vestibular and cochlear efferent neurons after labyrinthectomy in the rat


Strial dysfunction in a melanocyte deficient mutant rat (Ws/Ws rat)

A homozygous mutant rat at the white spotting (Ws) locus showing a deficiency of melanocytes has recently been found (4, 5). The function and morphology of the inner ear of the Ws/Ws rat were examined by auditory brainstem response (ABR), endocochlear DC potential (EP), and electron microscopy. The mean ABR threshold of the Ws/Ws rat was significantly higher than that of the control +/+ rat. Most Ws/Ws rats showed no or very little EP. In electron microscopy, the stria vascularis of the Ws/Ws rat proved to be very thin and flat with poor interdigitation of marginal cells, and absence of intermediate cells. The organ of Corti appeared to be intact in both the +/+ rat and the Ws/Ws rat. These electrophysiological and morphological findings suggest that the Ws/Ws rat suffered from severe hearing loss caused by strial dysfunction.


めまいに対するイブジラストの治療効果 --- 医師の評価と患者による日常生活の障害の改善か


Effect of unilateral vestibular stimulation on histamine release from the hypothalamus of rats in vivo

1. We investigated the effect of unilateral vestibular stimulation on histamine release from the anterior hypothalamic area of urethan-anesthetized rats in vivo, using a brain microdialysis method coupled with high-performance liquid chromatography fluorometry. 2. The histamine release was increased to approximately 180% of the basal release by the electrical stimulation of the inner ear with 1 Hz, 500 microA, and 200 ms for 20 min. This effect was dependent on the current intensity. 3. Activation of the unilateral horizontal semicircular canal by middle ear irrigation for 15 min with 45 degrees C water increased the histamine release to approximately 200% of the basal release. 4. Irrigation of the middle ear with ice water for 15 min increased the histamine release to approximately 190% of the basal release. 5. The histamine release was not changed by the irrigation of the middle ear with 37 degrees C water and the irrigation of the auricle with ice water, which suggests that neither somatosensory stimulation to the middle ear nor nonspecific cold stress affects the histamine release. 6. All these findings suggest that the sensory mismatch signals induced by caloric stimulation and unilateral electrical vestibular stimulation activate the histaminergic neuron system in the brain.


Changes in preproenkephalin mRNA after unilateral and bilateral labyrinthectomy in the rat medial vestibular nucleus

Brain Research. Molecular Brain Research


Pica in rats is analogous to emesis: An animal model in emesis research

Pharmacology, Biochemistry, and Behavior


Synaptic contact between vestibular afferent nerve and cholinergic efferent terminal: its putative mediation by nicotinic receptors


「トラベルミンSR錠」のラットの動揺病に対する抑制効果

「トラベルミンSR錠」のラットの動揺病に対する抑制効果


前庭型メニエール病と内リンパ水腫

前庭型メニエール病と内リンパ水腫


Vestibular, central and gastral triggering of emesis --- A study on individual susceptibility in rats

Using kaolin intake as a behavioral index of emesis in rats, we examined the relationship between susceptibility to motion sickness and to emesis induced by apomorphine or copper sulfate. Rats showed a wide variation in susceptibility to motion sickness. Significant positive correlations were found between susceptibility to motion sickness and to emesis induced by intraperitoneal administration of apomorphine and by oral administration of copper sulfate. Motion, apomorphine and copper sulfate induce emesis through different receptors, so these findings suggest that the sensitivity of a common locus of emesis, presumably the emetic center in the brain stem, is one determinant of individual differences in susceptibility to motion sickness.


Relationship between Ménière's Disease and Type Allergy --- Tested by MAST System

メニエール病におけるI型アレルギーの関与 --- MAST法を用いて


Uvula-nodulus and gravity direction (a study on vertical optokinetic-oculomotor functions)

Some characteristics of vertical optokinetic nystagmus and after-nystagmus, in particular, its up/down gain asymmetry, are known to be influenced by gravity direction, which is basically perceived by otolith organs. However, how such an information of gravity direction is processed within the central nervous system is not well understood, even though the role of cerebellar uvula and nodulus in vertical eye movements has been identified for some time. Accordingly, in this study, vertical optokinetic nystagmus and after-nystagmus were studied in squirrel monkeys both in the upright and side-lateral positions (different gravity direction to the head), before and after uvulonodulectomy. When the optokinetic stimulus was given, the slow phase eye velocity of optokinetic nystagmus was significantly higher in the side-lateral position than that obtained in the upright position. This difference disappeared after uvulonodulectomy. When the initial slow phase eye velocity of optokinetic after-nystagmus was compared, the one obtained in the side-lateral position was significantly higher than that acquired in the upright position. This difference also disappeared after the uvulonodular ablation. Thus, in this study of vertical optokinetic nystagmus and after-nystagmus, the role of uvula and nodulus in relaying the information of gravity direction was confirmed.


α-fluoromethylhistidine but not diphenhydramine prevents motion-induced emesis in the cat

This study seeks to evaluate the comparative role of alpha-fluoromethylhistidine and diphenhydramine in the prevention of motion sickness. The role of histaminergic mechanisms in motion sickness were evaluated in a feline model. Twenty-six female cats were studied. A variety of doses of fluoromethylhistidine and diphenhydramine were administered before motion testing. Fluoromethylhistidine was effective in preventing motion sickness. The efficacy was dose dependent. In contrast, diphenhydramine failed to prevent motion sickness in any of the tested doses. The failure of diphenhydramine to prevent motion sickness was unexpected. This may reflect the route of administration or the animal model studied. Depletion of histamine with fluoromethylhistidine prevented motion sickness in cats. Our results suggest that this drug may provide a very long duration of protection in cats.


Nasal mucosa sensitization with toluene diisocyanate (TDI) increases preprotachykinin A (PPTA) and preproCGRP mRNAs in guinea pig trigeminal ganglion neurons


Effect of capsaicin desensitization on nasal allergy-like symptoms and histamine release in the nose induced by toluene diisocyanate in guinea pigs.


Effects of capsaicin desensitization on nasal allergy-like symptoms and histamine release in the nose induced by toluene diisocyanate in guinea pigs

Intranasal application of toluene diisocyanate (TDI) induced nasal allergy-like symptoms of sneezing and watery rhinorrhea and decreased the histamine content of the nasal mucosa in guinea pigs. However, in the animals pretreated with capsaicin (capsaicin desensitization) before sensitization with TDI, nasal allergy-like symptoms were not induced. Capsaicin desensitization also inhibited histamine release in the nasal mucosa induced by TDI. These findings suggest that antidromic impulses of capsaicin-sensitive sensory nerves stimulated by TDI cause histamine release from mast cells in the nasal mucosa, resulting in nasal discharge and sneezing in guinea pigs. Thus neurogenic inflammation via an axon reflex in the nose may contribute to the pathogenesis of vasomotor rhinitis.


Coexistence of acetylcholine and calcitonin gene-related peptide in the vestibular efferent neurons in the rat


Vestibulo-ocular reflex in eccentric rotation in squirrel monkeys


めまい患者の自律神経機能 --- 圧受容器反射による検討

めまい患者の自律神経機能 --- 圧受容器反射による検討


Catecholaminergic responses to rotational stress in rat brain stem --- implications for amphetamine therapy of motion sickness

Aviation, Space, and Environmental Medicine


Effects of anti-cholinergic and cholinergic drugs on habituation to motion in rats

The effects of the anti-cholinergic drug scopolamine, an anti-motion sickness drug, and of the cholinergics physostigmine and neostigmine on habituation to motion sickness in rats were examined using pica, measured as eating of kaolin, as a behavioural index of motion sickness in rats. Rats were rotated around two axes for 1 h once a day for 10 or 11 days. Rotation-induced kaolin intake of control rats gradually decreased from day 9 of daily rotation. Test rats were not treated for the first 3 days, given drugs on days 4-7 of rotation and then again given no drugs for the next 3 or 4 days. Rotation-induced kaolin intake of test rats was compared to that of controls. Results showed that TTS (Transdermal Therapeutic System)-scopolamine administration facilitated habituation to rotation, whereas physostigmine, a centrally acting cholinesterase inhibitor, suppressed it, and neostigmine, a peripherally active cholinesterase inhibitor, had no effect on habituation at all. These findings suggest that the central cholinergic neuron system plays an important role in the neural mechanism of habituation to motion in rats.


The effect of saccular ablation on vertical optokinetic after-nystagmus in squirrel monkeys

European Archives of Oto-Rhino-Laryngology


Recovery of the otolith-ocular reflex after unilateral deafferentation of the otolith organs in squirrel monkeys

The enhancement of the vestibulo-ocular reflex (VOR) gain in the eccentric rotation is mediated by the otolith organs. Functional recovery of the otolith-ocular reflex after deafferentation of the otolith organs was examined in squirrel monkeys, using the enhancement of the eccentric VOR gain as an indicator of the reflex. After unilateral deafferentation of the otolith organs, the enhancement of the eccentric VOR gain decreased and then recovered completely within eight weeks. However, the eccentric VOR gain was not enhanced after contralateral side lesions. These findings demonstrate that functional recovery of the otolith-ocular reflex is achieved after unilateral deafferentation of the otolith organs, and that afferents from the remaining otolith organs are necessary for the functional compensation.


Effect of vestibulo-cerebellar lesions on asymmetry of vertical optokinetic functions in the squirrel monkey


Immunocytochemical localization of mitochondrial and cytosolic aspartate aminotransferase isozymes in the vestibular end-organs of rats


めまい患者に対する抗不安薬 etizolam の有効性 --- 二重盲検比較試験による臨床成績


Autonomic indexes during the vestibular-visual conflict exposure: a squirrel monkey study


Localization, origin and fine structure of calcitonin gene-related peptide-containing fibers in the vestibular end-organs of the rat


内耳局所水分代謝異常が原因と思われたレルモワイエ症候群の1症例

内耳局所水分代謝異常が原因と思われたレルモワイエ症候群の1症例


Localization of calcitonin gene-related peptide in the vestibular end-organs in the rat: an immunohistochemical study


水分代謝障害を背景に持つと思われたレルモワイエ症候群の1症例

水分代謝障害を背景に持つと思われたレルモワイエ症候群の1症例


Effects of ethyl alcohol and heavy-water administration on vestibulo-ocular reflex in rabbits

ORL; Journal for Oto-Rhino-Laryngology and Its Related Specialties


Effects of anti-motion sickness drugs on motion sickness in rats


Pica as an index of motion sickness of rats


Localization and fine structure of calcitonin gene-related peptide (CGRP)-like immunoreactive nerve fibres in the organ of Corti of guinea pigs by immunohistochemistry

The localization and fine structure of calcitonin gene-related peptide (CGRP)-like immunoreactive (CGRPI) fibres in the guinea pig cochlea were examined using immunohistochemistry. Numerous CGRPI fibres were located in the inner spiral bundle corresponding to the lateral system of the olivocochlear bundle. Immunoelectron microscopic analysis demonstrated that the CGRPI fibres belonged to the efferent terminals and some of them made synaptic contacts with peripheral neurites of the auditory nerve. These findings suggested that the olivocochlear CGRP neuron system influenced the neural activity of the auditory nerve, which conveys auditory information from the cochlea to the central nervous system.


Histaminergic mechanism of motion sickness --- Neurochemical and neuropharmacological studies in rats


The presence of a calcitonin gene-related peptide in the olivocochlear bundle in rat


Localization of calcitonin gene-related peptide in the organ of Corti of the rat: an immunohistochemical study


突発性難聴に対する脱線維素原療法について

突発性難聴に対する脱線維素原療法について


Origins of histamine-containing fibers in the cerebral cortex of rats studied by immunohistochemistry with histidine decarboxylase as a marker and transection


Immunohistochemical Evidence for the Coexistence of Histidine Decarboxylase-Like and Glutamate Decarboxylase-Like Immunoreactivities in Nerve Cells of the Magnocellular Nucleus of the Posterior Hypothalamus of Rats

Proceedings of the National Academy of Sciences of the United States of America


Effect of a new eburnamine derivative, RU 24722, on the turnover of monoamines in mouse brain --- Selective and reversible decrease of noradrenaline


Fine structure of histaminergic neurons in the caudal magnocellular nucleus of the rat as demonstrated by immunocytochemistry using histidine decarboxylase as a marker

The morphology of histamine-containing neurons in the caudal magnocellular nucleus was light and electron microscopically examined by means of peroxidase-antiperoxidase (PAP) immunocytochemistry with histidine decarboxylase (HDC) as a marker. HDC-like immunoreactive (HDCI) neurons had large (25-30 microns in diameter) perikarya from which two to four primary dendrites arose. The perikarya had a nearly round nucleus and well-developed Golgi apparatus in addition to a large number of mitochondria and rough endoplasmic reticulum. Immunoreactive endproducts were found diffusely throughout the perikarya, dendrites, and axons. HDCI neurons made synaptic contact with nonreactive axon terminals on the perikarya and dendrites. In addition, the HDCI neurons very frequently formed puncta adherentia with neuronal elements, either HDCI or nonreactive, or glial cells. Most of the HDCI axon terminals serially observed under electron microscopy did not exhibit typical synaptic contact in the caudal magnocellular nucleus. These findings suggest the nonsynaptic release of histamine in the caudal magnocellular nucleus.


興味ある経過を示した起立性低血圧症例:血圧と眼振の関係

興味ある経過を示した起立性低血圧症例:血圧と眼振の関係


ノルアドレナリンの血液粘稠度およびその規定因子におよぼす影響 --- 自律神経機能との関係


耳下腺内リンパ節原発悪性リンパ腫:症例と文献的考察

耳下腺内リンパ節原発悪性リンパ腫:症例と文献的考察


第34回日耳鼻秋季大会を終えて

第34回日耳鼻秋季大会を終えて


Clinical practice guideline of Meniere's disease

メニエール病診療ガイドライン

Otolaryngology-Head and Neck Surgery (Tokyo)


Seven-year follow-up of infants born in 2004 in Tokushima with bilateral hearing loss diagnosed without newborn hearing screening

新生児聴覚スクリーニングを受けずに診断された両側難聴児の追跡調査:徳島県で平成16年度に出生した両側難聴児の7年間の経過


MPO-ANCA関連中耳疾患の取り扱い

MPO-ANCA関連中耳疾患の取り扱い


今日の耳鼻咽喉科頭頸部外科治療指針

今日の耳鼻咽喉科頭頸部外科治療指針


Hunt症候群における内耳道造影MRIの検討

Hunt症候群における内耳道造影MRIの検討


ボツリヌス治療とバイオフィードバック療法の併用による病的共同運動の治療

ボツリヌス治療とバイオフィードバック療法の併用による病的共同運動の治療


末梢性顔面神経麻痺後に発症したGuillain-Barre症候群の1例

末梢性顔面神経麻痺後に発症したGuillain-Barre症候群の1例


EVALUATION OF ENOG IN THE EARLY STAGE OF FACIAL NERVE PARALYSIS

顔面神経麻痺発症早期ENoGの検討


EVALUATION OF PATHOLOGICAL SYNKINESIS (DEVIATION IN THE POSITION OF THE LIPS AT BLINKING) BY EMPLOYING A BIO-IMPEDANCE METER

生体インピーダンス測定装置による病的共同運動(瞬目時の口唇の偏位)の評価


Up-regulation of histamine H1 receptors in an allergic rat nasal mucosa model


Increase in the level of histidine decarboxylase mRNA expression in nasal mucosa of rats sensitized by toluene diisocyanate


眼裂比を用いた病的共同運動の評価

眼裂比を用いた病的共同運動の評価


外耳道に生じたリンパ腫様丘疹症例

外耳道に生じたリンパ腫様丘疹症例


TDI感作ラットにおけるヒスタミンH1受容体，ヒスチジン脱炭酸酵素発現

TDI感作ラットにおけるヒスタミンH1受容体，ヒスチジン脱炭酸酵素発現


ローリングマウス小脳におけるカルレチニン陽性 unipolar brush cell と CRF 陽性苔状線維終末


Three-Dimensional Eye Movement Simulator Extracting Instantaneous Eye Movement Rotation Axes, the Plane Formed by Rotation Axes, and Innervations for Eye Muscles

We have developed a three-dimensional eye movement simulator that simulates eye movement. The simulator allows us to extract the instantaneous eye movement rotation axes from clinical data sequences. It calculates the plane formed by rotation axes and displays it on an eyeball with rotation axes. It also extracts the innervations for eye muscles. The developed simulator is mainly programmed by a CG programming language. OpenGL First, the simulator was applied to saccadic eye movement data in order to show the so-called Listing's plane on which all hypothetical rotation axes lie. Next, it was applied to clinical data sequences of two patients with benign paroxysmal positional vertigo (BPPV) Instantaneous actual rotation axes and innervations for eye muscle extracted from data sequences have special characteristics. These results are useful for the elucidation of the mechanism of vestibular symptoms, particularly vertigo.

IEICE Transactions on Information and Systems


頭部外傷後の大錐体神経障害による味覚障害の1例

頭部外傷後の大錐体神経障害による味覚障害の1例


末梢性顔面神経麻痺後の後遺症発症患者のQOL

末梢性顔面神経麻痺後の後遺症発症患者のQOL


病的共同運動の発症を予防するためのバイオフィードバック療法の開始時期と訓練期間について


厚生労働省科学研究補助金，特定疾患対策研究事業，前庭機能異常に関する調査研究報告書


良性発作性頭位めまい症の半規管動特性

良性発作性頭位めまい症の半規管動特性


Ramsay Hunt 症候群におけるめまいと難聴の長期予後

Ramsay Hunt 症候群におけるめまいと難聴の長期予後


病的共同運動の発症を予防するためのバイオフィードバック療法の適応について

病的共同運動の発症を予防するためのバイオフィードバック療法の適応について


ボツリヌス治療とバイオフィードバック療法の併用による病的共同運動の治療

ボツリヌス治療とバイオフィードバック療法の併用による病的共同運動の治療


Bechtrew's現象と中枢前庭神経回路

Bechtrew's現象と中枢前庭神経回路


末梢性顔面神経麻痺の発症早期における瞬目煩瑣の興奮性の検討

末梢性顔面神経麻痺の発症早期における瞬目煩瑣の興奮性の検討


顔面神経麻痺後の病的共同運動の予防 --- ハードディスク録画再生装置を用いた訓練療法


Noradrenergic pathways involved in the development of vertigo and dizziness--a review

In this study, vestibular caloric stimulation (CS) inhibited noradrenergic (NA) neurons of the locus coeruleus (LC) in rats. The vestibular input can be modified by the ventrolateral medulla (VLM), which then inhibits the LC neuronal activity via GABAA receptors. Clinically, CS induces vertigo in humans. Thus, LC-NA inhibition may be involved in the development of vertigo. Moreover, it is speculated that Sopite syndrome, one of the major symptom complexes of motion sickness, is also evoked by LC-NA inhibition. The central LC-NA neuronal system may participate in vertigo and motion sickness independent of the histaminergic neuronal system. In contrast, the cholinergic neuronal system may mediate LC-NA inhibition during the vestibulo-atonomic reflex. The LC-NA system projects to most higher centers and affects sensory information processing. Therefore, it is suggested that the suppression of sensory information processing induced by LC-NA inhibition causes drowsiness, one of the major symptoms of vertigo and motion sickness. It is also speculated that LC-NA inhibition participates in the development of sensory mismatch during vertigo and motion sickness.


Information processing of visually-induced apparent self motion in the cortex of humans: analysis with magnetoencephalography.

The cortical site which processes information on whole-body linear displacement is unknown. In this study, neuromagnetic responses to a visually-induced linear vection were recorded in 5 healthy, right-handed, adult subjects using a 122-channel whole cortex neuromagnetometer. We presented expanding rectangles on the screen which came into view one after another and accelerated in expanding speed at random cycle, giving the subjects the sensation of linear self motion (linear vection) through an illusory tunnel with occasional acceleration. Clear responses of magnetic fields related to the accelerative event were obtained in both hemispheres around the parietal and temporal regions. The dipole sources of the component were estimated in the cortex around the superior temporal sulcus, insula and medial superior temporal area. Some parts of these regions may have been comprised in the vestibular cortex, suggesting that it processes the sensation of linear self motion and plays an important role in space perception.


EARLY DIAGNOSIS OF RAMSAY HUNT SYNDROME : SIGNIFICANCE OF SCHIRMER'S TEST

Hunt 症候群の早期診断について:流涙検査法の意義


前庭小脳グルタミン酸受容体デルタ2の前庭代償への関与

前庭小脳グルタミン酸受容体デルタ2の前庭代償への関与


病的共同運動の予防を目的としたバイオフィードバック療法の効果

病的共同運動の予防を目的としたバイオフィードバック療法の効果


前庭代償過程における小脳片葉 unipolar brush cell におけるNOの役割


Molecular mechanisms of vestibular compensation in the central vestibular system--review


Histaminergic influence on vestibular stimulation-induced locus coeruleus inhibition in rats


Sensory response of the locus ceruleus: neonatal and adult studies


前庭代償における小脳プロテイン・フォスファターゼ2Aの関与 --- Differential Display を用いた前庭代償関連因子の検索


Vestibular influences on the histaminergic and cholinergic systems in the rat brain

Annals of the New York Academy of Sciences


GABAA レセプターγ1 ，γ2 サブユニットの前庭神経節における発現

GABAA レセプターγ1 ，γ2 サブユニットの前庭神経節における発現


33 神経切断後に認められた顔面神経ニューロンでの cAMP 依存性プロテインキナーゼ発現変化


Nystagmus measured by ENG after stapes surgery


Vestibular modulation of the septo-hippocampal cholinergic system of rats


Responses of locus coeruleus neurons to caloric stimulation in rats


Changes in Fos and Jun expression in the rat brainstem in the process of vestibular compensation


Clinical investigation of the vestibular cortex


The Japanese Journal of Thoracic Diseases


Sympatho-vascular mechanism of vertigo attack in Meniere's disease

Meniere's Disease: Perspectives in the 90's


Effects of acute decrease in systemic blood pressure on canal oxygen concentration and per-rotational nystagmus in guinea pigs with endolympahtic hydrops


前庭遠心系における神経伝達物質について

前庭遠心系における神経伝達物質について


呼吸上皮知覚神経系:免疫組織化学法，in situ ハイブリダイゼーション法

呼吸上皮知覚神経系:免疫組織化学法，in situ ハイブリダイゼーション法


Nystagmus responses in normal subjects during eccentric sinusoidal rotation


Motion sickness induced by sinusoidal linear acceleration in rats


めまい:メニエール症候群

めまい:メニエール症候群


メラノサイト欠損ラットにおける聴覚機能

メラノサイト欠損ラットにおける聴覚機能


メニエール病患者の自律神経機能動態について --- 交感神経機能，副交感神経機能，両側面か


めまい患者の自律神経機能: R-R 間隔の周波数分析を用いた検討

めまい患者の自律神経機能: R-R 間隔の周波数分析を用いた検討


Inner ear function and Morphology of a Ws/Ws rat


Acetylcholine in the rat vestibular efferent system


Effects of anti-emetics on motion sickness of rats

Proceedings of the 3rd International Symposium on Space Medicine in Nagoya 1992


Effect of caloric stimulation of histaminergic neuron system of rats

Proceedings of XVII Barany Society Meeting


Changes in gene-expression of neuropeptides after unilateral labyrinthectomy in the rat brain stem


Cholinergic innervation in the rat vestibular end-organs


Pharmacology of motion-induced emesis of rats


前庭型メニエール病の蝸電図検査

前庭型メニエール病の蝸電図検査


メニエール病患者の自律神経機能について:サーモグラフィーを用いて

メニエール病患者の自律神経機能について:サーモグラフィーを用いて


ストレス負荷時の椎骨動脈，総頚動脈血流の変化

ストレス負荷時の椎骨動脈，総頚動脈血流の変化


Pharmacology of motion and space sickness

Proceedings of International Conference on the Vestibular Nervous System in Space


Centric and eccentric VOR tests in patients with Meniere's disease and vestibular Meniere's disease


Effects of otolith stimulation in eccentric rotation on the vestibulo-ocular reflex in squirrel monkeys


メニエール病患者の自律神経機能について(サーモグラフィーを用いて)

メニエール病患者の自律神経機能について(サーモグラフィーを用いて)


Centric, Eccentric VOR からみたメニエール病の評価:特に前庭型メニエール病


上気道粘膜における neuropeptide の分布について

上気道粘膜における neuropeptide の分布について


動揺病の発症要因としての加速度刺激の意義 --- 動揺病の動物モデルを用いて

動揺病の発症要因としての加速度刺激の意義 --- 動揺病の動物モデルを用いて


ラット前庭末梢 CGRP 含有神経線維の電子顕微鏡的観察

ラット前庭末梢 CGRP 含有神経線維の電子顕微鏡的観察


超音波ドップラー血流計を用いた循環改善剤の評価について

超音波ドップラー血流計を用いた循環改善剤の評価について


メニエール病の長期の聴力変化について

メニエール病の長期の聴力変化について


病態との関与:鼻過敏症と神経ペプチド

病態との関与:鼻過敏症と神経ペプチド


ocalization and origins of calcitonin gene-related peptide containing fibres in the vestibular end-organs of the rat


ラット前庭におけるCGRP含有神経線維の分布

ラット前庭におけるCGRP含有神経線維の分布


メニエール病患者の自律神経機能6-ハイドロキシドーパミン及びアンフェタミン投与時の家兎圧受容器反射感度について


メニエール病患者の自律神経機能について

メニエール病患者の自律神経機能について


総合的平衡機能検査装置(MVM-C2)による Centric 及び Eccentric VOR 検査


Effects of deuterium oxide and ethyl alcohol on vestibulo-ocular reflex in rabbits


Is the noradrenergic neuron system in the brain stem related to motion sickness in rats


ラット聴覚前庭系における活性物質の分布

ラット聴覚前庭系における活性物質の分布


総合的平衡機能検査装置(MVM-C2)による前庭機能異常患者の評価

総合的平衡機能検査装置(MVM-C2)による前庭機能異常患者の評価


Role of histamine in motion sickness and space motion sickness


Histaminergic projection from the posterior hypothalamus to the medial vestibular nucleus of rats and its relation to motion sickness

The Vestibular System: Neurophysiological and Clinical Research


ラット内耳における calcitonin gene-related peptide (CGRP) 含有神経線維の分布について


めまい患者における起立負荷試験と血中カテコラミンの関係

めまい患者における起立負荷試験と血中カテコラミンの関係


Purication of and antibodies against L-histidine decarboxylase

Frontiers in Histamine Research - A Tribute to Heinz Schild (Hardcover)


ラット内耳における calcitonin gene-related peptide (CGRP) 含有神経線維の分布とその投射路


Histaminergic projection from the posterior hypothalamus to the medial vestibular nucleus in rats

Sensory-motor Function under Weightlessness and Space Motion Sickness


Bell麻痺患者における交感神経機能

Bell麻痺患者における交感神経機能


Autonomic Dysfunction in Patients with Vertigo