read0013690/published_papers/15122607 Munehisa Fukushima Tadashi Kitahara Ryohei Oya Shiro Akahani Hidenori Inohara Shin Naganawa Noriaki Takeda Longitudinal up-regulation of endolymphatic hydrops in patients with Meniere's disease during medical treatment Laryngoscope Investigative Otolaryngology 2378-8038 2 6 344 350 20171200 10.1002/lio2.115 29299506 read0013690/published_papers/15122608 Eiji Kondo Osamu Jinnouchi Seiichi Nakano Hiroki Ohnishi Ikuji Kawata Hidehiko Okamoto Noriaki Takeda Aural stimulation with capsaicin ointment improved swallowing function in elderly patients with dysphagia: A randomized, placebo-controlled, double-blind, comparative study Dove Medical Press Ltd. Clinical Interventions in Aging 1178-1998 12 1921 1928 20171113 10.2147/CIA.S138357 29180855 2-s2.0-85034586599 read0013690/published_papers/15122609 Munehisa Fukushima Kei Yokoi Junpei Iga Shiro Akahani Hidenori Inohara Noriaki Takeda Contralateral type of delayed endolymphatic hydrops may consist of two phenotypes based on a magnetic resonance imaging preliminary study Taylor and Francis Ltd Acta Oto-Laryngologica 1651-2251 137 11 1153 1157 20171102 10.1080/00016489.2017.1347825 28686071 2-s2.0-85022098315 read0013690/published_papers/15122610 Yui Takahara 高原 由衣 Kumi Satoh 佐藤 公美 Takaaki Takeyama 竹山 孝明 Yuki Sakamoto 坂本 幸 Toshihito Aoki 青木 俊仁 伊藤 美幸 池田 美穂 田上 真希 吉田 充嬉 岡田 規秀 Jiro Udaka 宇高 二良 Aki Shimada 島田 亜紀 Noriaki Takeda 武田 憲昭 学校検診における嗄声の出現率とスポーツ活動 The Japan Journal of Logopedics and Phoniatrics 音声言語医学 1884-3646 58 4 326 332 20171020 10.5112/jjlp.58.326 read0013690/published_papers/15122611 Takao Imai Yasumitsu Takimoto Noriaki Takeda Tomoko Okumura Hidenori Inohara Three-dimensional analysis of linear vestibulo-ocular reflex in humans during eccentric rotation while facing downwards Springer Verlag Experimental Brain Research 1432-1106 235 8 2575 2590 20170801 10.1007/s00221-017-4990-8 28560493 2-s2.0-85019749105 read0013690/published_papers/15122615 Syuji Yonekura Yoshitaka Okamoto Daiju Sakurai Toshioki Sakurai Tomohisa Iinuma Heizaburou Yamamoto Toyoyuki Hanazawa Shigetoshi Horiguchi Yuichi Kurono Kohei Honda Yuichi Majima Keisuke Masuyama Noriaki Takeda Shigeharu Fujieda Mitsuhiro Okano Satoshi Ogino Kimihiro Okubo Complementary and alternative medicine for allergic rhinitis in Japan Japanese Society of Allergology Allergology International 1440-1592 66 3 425 431 20170701 10.1016/j.alit.2016.10.006 27884625 2-s2.0-85007021324 read0013690/published_papers/15122612 Suzuyo Okazaki Takao Imai Kayoko Higashi-Shingai Kazunori Matsuda Noriaki Takeda Tadashi Kitahara Atsuhiko Uno Arata Horii Yumi Ohta Tetsuo Morihana Chisako Masumura Suetaka Nishiike Hidenori Inohara Office-based differential diagnosis of transient and persistent geotropic positional nystagmus in patients with horizontal canal type of benign paroxysmal positional vertigo Taylor and Francis Ltd Acta Oto-Laryngologica 1651-2251 137 3 265 269 20170304 10.1080/00016489.2016.1227478 27644766 2-s2.0-84988443712 read0013690/published_papers/15122616 Tomoko Okumura Takao Imai Yasumitsu Takimoto Noriaki Takeda Tadashi Kitahara Atsuhiko Uno Takefumi Kamakura Yasuhiro Osaki Yoshiyuki Watanabe Hidenori Inohara Assessment of endolymphatic hydrops and otolith function in patients with Ménière's disease. Ménière's disease is associated with hydrops of the inner ear endolymphatic space, and histopathologically, the cochlea and vestibule are usually involved. We used gadolinium-enhanced magnetic resonance imaging and measured cervical and ocular vestibular evoked myogenic potentials and the gain in the utricular induced linear vestibulo-ocular reflex to test the hypothesis that vestibular hydrops in Ménière's disease patients is associated with otolith organ dysfunction. We evaluated 21 patients diagnosed with unilateral definitive Ménière's disease using gadolinium magnetic resonance imaging to detect endolymphatic hydrops in the cochlea and vestibule. Cervical and ocular vestibular evoked myogenic potentials and the gain in utricular induced linear vestibulo-ocular reflex during eccentric rotation were measured to assess otolith organ function. For eccentric rotation, patients were rotated while displaced from the axis of rotation, while linear acceleration stimulated the utricle and induced the vestibulo-ocular reflex. Magnetic resonance imaging revealed vestibular hydrops in 14 of 20 patients (70%). Among the 14 patients, ten (71%) had abnormal cervical and three (21%) had abnormal ocular vestibular evoked myogenic potentials. Four patients (4/21, 19%) had abnormal linear vestibulo-ocular reflexes, three of whom also had abnormal ocular vestibular evoked myogenic potentials. Overall, 16 of 17 patients had normal linear vestibulo-ocular reflexes and normal ocular vestibular evoked myogenic potentials. Vestibular endolymphatic hydrops in Ménière's disease patients caused otolith organ dysfunction, mainly in the saccule. The number of Ménière's disease patients with abnormal ocular vestibular evoked myogenic potentials was low (19%), and they also had abnormal utricular induced linear vestibulo-ocular reflexes. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 1434-4726 274 3 1413 1421 20170300 10.1007/s00405-016-4418-2 27942898 read0013690/published_papers/15122614 Takao Imai on behalf of Committee for Standards in Diagnosis of Japan Society for Equilibrium Research Noriaki Takeda Tetsuo Ikezono Kohichiro Shigeno Masatsugu Asai Yukio Watanabe Mamoru Suzuki Classification, diagnostic criteria and management of benign paroxysmal positional vertigo Elsevier Ireland Ltd Auris Nasus Larynx 1879-1476 44 1 1 6 20170201 10.1016/j.anl.2016.03.013 27174206 2-s2.0-84965122429 read0013690/published_papers/15122613 Naoki Toda 戸田 直紀 松岡 百百世 Yohji Hori 堀 洋二 Hitoshi Shiyouno 庄野 仁志 Mika Takahashi 橋 美香 Katsuhiko Nakamura 中村 克彦 Noriaki Takeda 武田 憲昭 顔面や頸部に帯状疱疹を伴った顔面神経麻痺の3例 Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 102 2 89 93 20170200 10.5631/jibirin.110.89 read0013690/published_papers/15122929 Noriaki Takeda 武田 憲昭 Kazunori Matsuda 松田 和徳 Gou Satou 佐藤 豪 メニエール病診療ガイドライン 耳鼻咽喉科・頭頸部外科 89 1 36 40 20170100 read0013690/published_papers/15122618 Yoshiro Wada Suetaka Nishiike Tadashi Kitahara Toshiaki Yamanaka Takao Imai Taeko Ito Go Sato Kazunori Matsuda Yoshiaki Kitamura Noriaki Takeda Effects of repeated snowboard exercise in virtual reality with time lags of visual scene behind body rotation on head stability and subjective slalom run performance in healthy young subjects. CONCLUSION: After repeated snowboard exercises in the virtual reality (VR) world with increasing time lags in trials 3-8, it is suggested that the adaptation to repeated visual-vestibulosomatosensory conflict in the VR world improved dynamic posture control and motor performance in the real world without the development of motion sickness. OBJECTIVES: The VR technology was used and the effects of repeated snowboard exercise examined in the VR world with time lags between visual scene and body rotation on the head stability and slalom run performance during exercise in healthy subjects. METHODS: Forty-two healthy young subjects participated in the study. After trials 1 and 2 of snowboard exercise in the VR world without time lag, trials 3-8 were conducted with 0.1, 0.2, 0.3, 0.4, 0.5, and 0.6 s time lags of the visual scene that the computer creates behind board rotation, respectively. Finally, trial 9 was conducted without time lag. Head linear accelerations and subjective slalom run performance were evaluated. RESULTS: The standard deviations of head linear accelerations in inter-aural direction were significantly increased in trial 8, with a time lag of 0.6 s, but significantly decreased in trial 9 without a time lag, compared with those in trial 2 without a time lag. The subjective scores of slalom run performance were significantly decreased in trial 8, with a time lag of 0.6 s, but significantly increased in trial 9 without a time lag, compared with those in trial 2 without a time lag. Motion sickness was not induced in any subjects. Acta oto-laryngologica 1651-2251 136 11 1121 1124 20161100 10.1080/00016489.2016.1193890 27319356 read0013690/published_papers/15122621 Yoshiaki Kitamura Hiroyuki Mizuguchi Kentaro Okamoto Mika Kitayama Tatsuya Fujii Akira Fujioka Toshio Matsushita Takashi Mukai Yoshiaki Kubo Nobuo Kubo Hiroyuki Fukui Noriaki Takeda Irradiation with narrowband-ultraviolet B suppresses phorbol ester-induced up-regulation of H 1 receptor mRNA in HeLa cells Taylor and Francis Ltd Acta Oto-Laryngologica 1651-2251 136 4 409 413 20160402 10.3109/00016489.2015.1129555 26824787 2-s2.0-84958059534 read0013690/published_papers/15122624 Hiroyuki Mizuguchi Asish K. Das Kazutaka Maeyama Shrabanti Dev Masum Shahriar Yoshiaki Kitamura Noriaki Takeda Hiroyuki Fukui Antihistamines suppress upregulation of histidine decarboxylase gene expression with potencies different from their binding affinities for histamine H1 receptor in toluene 2,4-diisocyanate-sensitized rats Japanese Pharmacological Society Journal of Pharmacological Sciences 1347-8648 130 4 212 218 20160401 10.1016/j.jphs.2016.02.002 26980430 2-s2.0-84960076791 read0013690/published_papers/15122630 Rie Tsutsumi Masakazu Goda Chisa Fujimoto Kyoko Kanno Misaki Nobe Yoshiaki Kitamura Koji Abe Misako Kawai Hideki Matsumoto Tohru Sakai Noriaki Takeda Effects of chemotherapy on gene expression of lingual taste receptors in patients with head and neck cancer John Wiley and Sons Inc. Laryngoscope 1531-4995 126 3 E103 E109 20160301 10.1002/lary.25679 26422579 2-s2.0-84946593728 read0013690/published_papers/15122625 Hiroyuki Mizuguchi Naoki Orimoto Takuya Kadota Takahiro Kominami Asish K. Das Akiho Sawada Misaki Tamada Kohei Miyagi Tsubasa Adachi Mayumi Matsumoto Tomoya Kosaka Yoshiaki Kitamura Noriaki Takeda Hiroyuki Fukui Suplatast tosilate alleviates nasal symptoms through the suppression of nuclear factor of activated T-cells-mediated IL-9 gene expression in toluene-2,4-diisocyanate-sensitized rats Japanese Pharmacological Society Journal of Pharmacological Sciences 1347-8648 130 3 151 158 20160301 10.1016/j.jphs.2015.12.008 26874672 2-s2.0-84957928465 read0013690/published_papers/15122622 Takao Imai Yasumitsu Takimoto Noriaki Takeda Atsuhiko Uno Hidenori Inohara Shoichi Shimada High-Speed Video-Oculography for Measuring Three-Dimensional Rotation Vectors of Eye Movements in Mice PLOS ONE 1932-6203 11 3 null null 20160300 10.1371/journal.pone.0152307 27023859 read0013690/published_papers/15122626 Manik Chandra Shill Hiroyuki Mizuguchi Sanmoy Karmakar Takuya Kadota Pulok K. Mukherjee Yoshiaki Kitamura Yoshiki Kashiwada Hisao Nemoto Noriaki Takeda Hiroyuki Fukui A novel benzofuran, 4-methoxybenzofuran-5-carboxamide, from Tephrosia purpurea suppressed histamine H1 receptor gene expression through a protein kinase C-δ-dependent signaling pathway Elsevier International Immunopharmacology 1878-1705 30 18 26 20160101 10.1016/j.intimp.2015.11.021 26619301 2-s2.0-84948402928 read0013690/published_papers/15122623 Chisa Fujimoto 藤本 知佐 Koichi Tamura 田村 公一 Noriaki Takeda 武田 憲昭 A case of laryngeal chondroma in the bilateral laminae of the thyroid cartilage 甲状軟骨両翼に生じた喉頭軟骨腫例 Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 109 3 183 188 20160000 10.5631/jibirin.109.183 2-s2.0-84959864419 read0013690/published_papers/15122620 Shizuka Takaishi 高石 静 Ryo Kanamura 金村 亮 Koji Abe 藤本 知佐 Noriaki Takeda 田村 公一 Chisa Fujimoto 阿部 晃治 Koichi Tamura 武田 憲昭 A case of foreign body in the ethmoid sinus diagnosed nine years after the dental implant surgery インプラント治療9年後に発覚した篩骨洞異物例 Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 109 6 393 397 20160000 10.5631/jibirin.109.393 2-s2.0-84973161034 read0013690/published_papers/15122619 Hironori Akizuki 秋月 裕則 Hidetaka Iwasaki 岩? 英隆 Noriaki Takeda 武田 憲昭 A case of subacute pharyngo-laryngeal swelling after accidental ingestion of dimethylammonium chloride 界面活性剤の誤飲により亜急性に生じた咽喉頭粘膜腫脹例 Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 109 6 405 409 20160000 10.5631/jibirin.109.405 2-s2.0-84973091505 read0013690/published_papers/15122617 Sei-Ichi Nakano Hidetaka Iwasaki Eiji Kondo Katsushi Miyazaki Haruhiko Shizuku Sei-Ichiro Kamimura Junya Fukuda Ryo Kanamura Noriaki Takeda Efficacy of proton pump inhibitor in combination with rikkunshito in patients complaining of globus pharyngeus University of Tokushima Journal of Medical Investigation 1349-6867 63 3-4 227 229 20160000 10.2152/jmi.63.227 27644563 2-s2.0-84987925216 read0013690/published_papers/15122631 Yuki Nariai Hiroyuki Mizuguchi Takeyasu Ogasawara T Ogasawara Hiroaki Nagai H Nagai Yohei Sasaki Y Sasaki Yasunobu Okamoto Y Okamoto Yoshiyuki Yoshimura Yoshiaki Kitamura Hisao Nemoto Noriaki Takeda Hiroyuki Fukui Disruption of heat shock protein 90 (Hsp90)-Protein Kinase Cδ (PKCδ) interaction by (-)-Maackiain suppresses histamine h1 receptor gene transcription in Hela cells Disruption of Heat Shock Protein 90 (Hsp90)-Protein Kinase Cδ (PKCδ) Interaction by (-)-Maackiain Suppresses Histamine H1 Receptor Gene Transcription in HeLa Cells American Society for Biochemistry and Molecular Biology Inc. Journal of Biological Chemistry The Journal of Biological Chemistry 1083-351X 290 45 27393 27402 20151106 10.1074/jbc.M115.657023 26391399 2-s2.0-84946594658 read0013690/published_papers/15122628 Yoshiaki Kitamura Hideyuki Nakagawa Tatsuya Fujii Takema Sakoda Tadao Enomoto Hiroyuki Mizuguchi Hiroyuki Fukui Noriaki Takeda Effects of antihistamine on up-regulation of histamine H1 receptor mRNA in the nasal mucosa of patients with pollinosis induced by controlled cedar pollen challenge in an environmental exposure unit Japanese Pharmacological Society Journal of Pharmacological Sciences 1347-8648 129 3 183 187 20151101 10.1016/j.jphs.2015.10.007 26598006 2-s2.0-84951292455 read0013690/published_papers/15122632 Hiroyuki Mizuguchi Yuki Nariai Shuhei Kato Tomohiro Nakano Tomoyo Kanayama Yoshiki Kashiwada Hisao Nemoto Kazuyoshi Kawazoe Yoshihisa Takaishi Yoshiaki Kitamura Noriaki Takeda Hiroyuki Fukui Maackiain is a novel antiallergic compound that suppresses transcriptional upregulation of the histamine H1 receptor and interleukin-4 genes Wiley-Blackwell Publishing Ltd Pharmacology Research and Perspectives 2052-1707 3 5 e00166 e00166 20151001 10.1002/prp2.166 26516579 2-s2.0-84948398882 read0013690/published_papers/15122636 Masakazu Goda Osamu Jinnouchi Tsukasa Takaoka Koji Abe Koich Tamura Yutaka Nakaya Yoshihito Furukita Hirokazu Takechi Akira Tangoku Noriaki Takeda Efficacy of percutaneous endoscopic gastrostomy on unplanned treatment interruption and nutritional status in patients undergoing chemoradiotherapy for advanced head and neck cancer University of Tokushima Journal of Medical Investigation 1349-6867 62 3 173 176 20150918 10.2152/jmi.62.173 26399343 2-s2.0-84942051222 read0013690/published_papers/15122633 Hiroaki Yanagawa Rumi Katashima Noriaki Takeda Research ethics committees in Japan: A perspective from thirty years of experience at Tokushima University University of Tokushima Journal of Medical Investigation 1349-6867 62 3 114 118 20150918 10.2152/jmi.62.114 26399332 2-s2.0-84942030598 read0013690/published_papers/15122635 Yoshiaki Kitamura 北村 嘉章 三好 仁美 松岡 百百世 Tatsuya Fujii 藤井 達也 Kazunori Matsuda 松田 和徳 Noriaki Takeda 武田 憲昭 鼻涙管下鼻甲介スイング法にて内視鏡下に摘出した上顎洞血瘤腫例 We report a 63-year-old woman with recurrent nasal bleeding diagnosed with organized hematoma in the maxillary sinus. Computed tomography showed an expanding lesion with thinning and defect of the adjacent bone and magnetic resonance imaging showed heterogeneous signal intensity with thickening of the maxillary sinus mucosa and marked patchy enhancement. After selective embolization of the feeding artery, we conducted endoscopic sinus surgery and applied the swinging technique of the nasolacrimal duct and inferior turbinate for resection of the organized hematoma. It provides a wide surgical field for the maxillary sinus, resulting in en bloc resection with a straight endoscope and instruments. The postoperative course was uneventful and no recurrence was observed in the 1.5-year follow-up. The swinging technique allows wide and direct access to the maxillary sinus through anterior space of the nasolacrimal duct without damaging the nasolacrimal duct or inferior turbinate mucosal function. This technique is a safe and effective method to remove benign maxillary sinus diseases endoscopically by good accessibility to and visualization of the maxillary sinus. 鼻涙管下鼻甲介スイング法を用いて内視鏡下に摘出した上顎洞血瘤腫例を経験したので報告する．症例は63歳女性で主訴は右鼻出血．CTでは右上顎洞内に膨張性の発育を示す軟部組織陰影が充満し，上顎洞自然口付近から腫瘤中心部にかけて不均一な造影効果を認めた．MRIではT1強調画像で等信号域，T2強調画像で辺縁が低信号域，内部が低信号域と高信号域が混在した腫瘤を認めた．画像所見から血瘤腫を疑い血管造影で栄養血管を確認し，手術前日に塞栓術を施行した．内視鏡下副鼻腔手術により，腫瘤を一塊に切除する目的で鼻涙管下鼻甲介スイング法を用いて摘出術を行った．まず粘膜下下鼻甲介骨切除術を行った後，下鼻道側壁粘膜を剥離し，鼻涙管と下鼻甲介粘膜を一塊として温存した．次に鼻涙管と下鼻甲介を内側・外側へスウィングさせながら上顎洞内側壁を広く切除し，上顎洞を大きく開放した．鼻涙管と下鼻甲介を内側へスウィングさせることで，鼻涙管の前方を経由して上顎洞へアプローチし，上顎洞内の大部分を直視鏡下に弯曲の少ない手術器具を用いて処理でき，血瘤腫を一塊に上顎洞粘膜から切除した．鼻涙管下鼻甲介スイング法は，鼻涙管や下鼻甲介粘膜機能を温存して上顎洞内の処理を広い術野で直視鏡下に行うことが可能であり，血瘤腫などの上顎洞を主座とする腫瘤性病変に広く有用であると考えられた． Japan Rhinologic Society 日本鼻科学会 Japanese Journal of Rhinology 日本鼻科学会会誌 0910-9153 54 1 25 30 20150500 10.7248/jjrhi.54.25 read0013690/published_papers/15122639 Kazuhiko Tahara 太原 一彦 Kazunori Sekine 関根 和教 Go Sato 佐藤 豪 Kazunori Matsuda 松田 和徳 Seiichiro Kamimura 神村 盛一郎 Takahiro Azuma 東 貴弘 Noriaki Takeda 武田 憲昭 The temperature of aural air stimulation equivalent to aural stimulation with water at 20°C in the caloric test 少量注水法に対応するエアーカロリック検査の刺激条件の検討 Japan Society for Equilibrium Research Equilibrium Research 0385-5716 74 1 15 19 20150201 10.3757/jser.74.15 2-s2.0-84927917146 read0013690/published_papers/15122638 Momoyo Matsuoka 松岡 百百世 Yoshiaki Kitamura 北村 嘉章 Koji Abe 遠藤 亜紀 Noriaki Takeda 阿部 晃治 Aki Endo 武田 憲昭 A case of sinonasal-type hemangiopericytoma resected with endoscopic sinus surgery 内視鏡下に摘出しえたsinonasal-type hemangiopericytoma例 Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 108 1 13 17 20150000 10.5631/jibirin.108.13 2-s2.0-84920364656 read0013690/published_papers/15122637 Takao Imai Kazunori Matsuda Noriaki Takeda Atsuhiko Uno Tadashi Kitahara Arata Horii Suetaka Nishiike Hidenori Inohara Light cupula: the pathophysiological basis of persistent geotropic positional nystagmus BMJ OPEN 2044-6055 5 1 null null 20150000 10.1136/bmjopen-2014-006607 25586370 read0013690/published_papers/15122634 Keisuke Naito 内藤 圭介 Aki Shimada 島田 亜紀 Masakazu Goda 合田 正和 Yoshiaki Kitamura 遠藤 亜紀 Koji Abe 北村 嘉章 Noriaki Takeda 阿部 晃治 Aki Endo 武田 憲昭 A case of adenomatoid odontogenic tumor in the maxillary canine 上顎犬歯から発生した腺様歯原性腫瘍例 Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 108 6 461 464 20150000 10.5631/jibirin.108.461 2-s2.0-84930268027 read0013690/published_papers/15122629 Tatsuya Fujii 藤井 達也 Kazunori Matsuda 松田 和徳 Noriaki Takeda 宮崎 かつし Katsushi Miyazaki 武田 憲昭 Effect of glutamine supplementation on chemoradiotherapy-induced mucositis in patients with head and neck cancer 頭頸部癌化学放射線療法による口内炎に対するグルタミン含有成分栄養剤の使用経験 Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 108 10 767 773 20150000 10.5631/jibirin.108.767 2-s2.0-84943161521 read0013690/published_papers/15122627 Eiji Kondo 近藤 英司 Osamu Jinnouchi 陣内 自治 Hiroki Ohnishi 大西 皓貴 Ikuji Kawata 川田 育二 Noriaki Takeda 武田 憲昭 Aural stimulation with capsaicin ointment improved the swallowing function in patients with dysphagia : Evaluation by the SMRC scale 外耳道へのカプサイシン軟膏刺激による嚥下障害患者の嚥下機能の改善 SMRCスケールを用いた評価 Oto-Rhino-Laryngological Society of Japan Inc. Journal of Otolaryngology of Japan 日本耳鼻咽喉科学会会報 0030-6622 118 11 1319 1326 20150000 10.3950/jibiinkoka.118.1319 26827596 2-s2.0-84964411208 read0013690/published_papers/15122642 Katsuhiko Nakamura 中村 克彦 Takahiro Azuma 東 貴弘 Naoki Toda 戸田 直紀 Hidetaka Iwasaki 岩? 英隆 Noriaki Takeda 武田 憲昭 小児集団リハビリテーションにおける病的共同運動治療の長期経過観察症例の検討 Facial Nerve Research Japan 0914-790X 34 78 80 20141200 read0013690/published_papers/15122641 Takahiro Azuma 東 貴弘 高橋 美香 Hidetaka Iwasaki 岩? 英隆 Naoki Toda 戸田 直紀 Katsuhiko Nakamura 中村 克彦 Noriaki Takeda 武田 憲昭 発症した病的共同運動に対するボツリヌス毒素・ミラーバイオフィードバック併用療法の治療開始時期による効果の検討 Facial Nerve Research Japan 0914-790X 34 81 83 20141200 read0013690/published_papers/15122640 Noriaki Takeda 武田 憲昭 神村 盛一郎 嶽村 貞治 太田 有美 森鼻 哲生 猪原 秀典 Yoshiaki Kitamura 北村 嘉章 Koji Abe 阿部 晃治 難治性中耳炎症状を呈するANCA陽性症例の疫学調査と診断基準の問題点に関する検討 It was reported that among the patients who complained of refractory otitis media-like symptoms, some had anti-neutrophil cytoplasmic autoantibodies (ANCA) in the serum, but did not meet the criteria of ANCA-associated vasculites such as granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA). Most of them showed a positive MPO-ANCA, but not PR3-ANCA in the serum with no pulmonary and renal lesions. Subsequently, these patients often suffered from sensorineural hearing loss and facial palsy. In 2011, we proposed the diagnostic term and criteria of MPO-ANCA-associated middle ear disease with sensorineural hearing loss and facial palsy (MPO-ANCA-associated middle ear disease). In the present epidemiological study, we examined 17 ANCA-positive patients with refractory otitis media-like symptoms from 25 affiliated hospitals. The diagnosis of GPA was given to 11 patients, while 6 patients were diagnosed as MPO-ANCA-associated middle ear disease. In the latter group of 6 patients, however, the diagnosis GPA was warranted on the basis of a positive MPO-ANCA in the serum. Indeed, it was reported that some patients with GPA that was diagnosed histopathologically, showed a positive MPO-ANCA in the serum. Therefore, the present study suggests that MPO-ANCA-associated middle ear disease should be classified as a subtype of GPA despite the lack of histopathological evidence of vasculitis. 近年，難治性中耳炎症状を呈するANCA陽性症例の報告が増加している．これらの症例の中には，ANCA関連血管炎であるGPA，MPA，EGPAの診断基準を満たさず，2011年に我々が提唱した感音難聴と顔面神経麻痺を示すMPO-ANCA関連中耳疾患 (以下，MPO-ANCA関連中耳疾患) が含まれる．今回我々は，難治性の中耳炎症状を呈するANCA陽性症例において，MPO-ANCA関連中耳疾患とANCA関連血管炎であるGPA，MPA，EGPAとの関係を明らかにする目的で，近畿と四国の関連病院25施設にアンケート調査を行い，17例の回答を得た．この17例は，診断基準に基づいてGPAとMPO-ANCA関連中耳疾患の2疾患に診断できた．さらに，仮にGPAの診断基準にMPO-ANCA陽性を追加すると，全例がGPAと診断できることが分った．全身型GPAにはMPO-ANCA陽性の症例も存在することから，難治性の中耳炎症状を呈するMPO-ANCA陽性でPR3-ANCA陰性のMPO-ANCA関連中耳疾患は，病理組織検査では血管炎の所見が得られないものの，疫学研究結果からは限局型GPAに含まれると考えられた． THE JAPAN OTOLOGICAL SOCIETY 日本耳科学会 Otology Japan 0917-2025 24 5 760 765 20141200 10.11289/otoljpn.24.760 read0013690/published_papers/15122645 Go Sato Kazunori Sekine Kazunori Matsuda Hitomi Ueeda Arata Horii Suetaka Nishiike Tadashi Kitahara Atsushi Uno Takao Imai Hidenori Inohara Noriaki Takeda Long-term prognosis of hearing loss in patients with unilateral Ménière's disease Informa Healthcare Acta Oto-Laryngologica 1651-2251 134 10 1005 1010 20141001 10.3109/00016489.2014.923114 25029391 2-s2.0-84907179827 read0013690/published_papers/15122644 Masafumi Sakagami 坂上 雅史 Yuichi Kurono 黒野 祐一 Akira Inokuchi 井之口 昭 Noriaki Takeda 武田 憲昭 Tsunemasa Aiba 愛場 庸雅 Tomomi Nin 任 智美 Minoru Ikeda 池田 稔 Time course of changes in gustatory function test results and subjective symptoms, and predictive factors for response in patients with taste disorder receiving 24-week zinc replacement treatment 味覚障害患者に対する24週間の亜鉛内服治療における味覚機能検査と自覚症状の経時的推移および効果予測因子 Oto-Rhino-Laryngological Society of Japan Inc. Journal of Otolaryngology of Japan 日本耳鼻咽喉科学会会報 0030-6622 117 8 1093 1101 20140801 10.3950/jibiinkoka.117.1093 25255648 2-s2.0-84907993465 read0013690/published_papers/15122648 Hitoshi Shono 庄野 仁志 Takahiro Azuma 東 貴弘 Kazunori Sekine 関根 和教 Koji Abe 阿部 晃治 Koichi Tamura 田村 公一 Noriaki Takeda 武田 憲昭 A Case of Descending Necrotizing Mediastinitis Treated with Continuous Saline Irrigation with a Pleated Drain 外科的ドレナージとプリーツドレーンによる持続洗浄が有効であった降下性壊死性縦隔炎例 Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 107 2 141 145 20140000 10.5631/jibirin.107.141 2-s2.0-84893330142 read0013690/published_papers/15122647 Yoshiaki Kitamura 北村 嘉章 Hiroyuki Mizuguchi 水口 博之 Hiroyuki Fukui 福井 裕行 Noriaki Takeda 武田 憲昭 The molecular mechanism of up-regulation of histamine H1 receptor mRNA in the nasal mucosa of patients with allergic rhinitis and the effect of antihistamine on histamine H1 receptor expression アレルギー性鼻炎におけるヒスタミンH1受容体遺伝子発現亢進の分子機構とその制御 Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 107 4 261 270 20140000 10.5631/jibirin.107.261 2-s2.0-84897512112 read0013690/published_papers/15122646 Hiroki Onishi 大西 皓貴 Mika Takahashi 高橋 美香 Koji Abe 阿部 晃治 Noriaki Takeda 武田 憲昭 A case of langerhans cell histiocytosis of the temporal bone 側頭骨に発生したランゲルハンス細胞組織球症例 Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 107 5 369 374 20140000 10.5631/jibirin.107.369 2-s2.0-84899828267 read0013690/published_papers/15122643 Eiji Kondo Osamu Jinnouchi Hiroki Ohnishi Ikuji Kawata Seiichi Nakano Masakazu Goda Yoshiaki Kitamura Koji Abe Hiroshi Hoshikawa Hidehiko Okamoto Noriaki Takeda Effects of aural stimulation with capsaicin ointment on swallowing function in elderly patients with non-obstructive dysphagia CLINICAL INTERVENTIONS IN AGING 1178-1998 9 1661 1667 20140000 10.2147/CIA.S67602 25328387 read0013690/published_papers/15122655 Hinami Nagashima Jiro Udaka Izumi Chida Aki Shimada Eiji Kondo Noriaki Takeda Air-bone gap estimated with multiple auditory steady-state response in young children with otitis media with effusion Auris Nasus Larynx 0385-8146 40 6 534 538 20131200 10.1016/j.anl.2013.03.002 23694737 2-s2.0-84881553765 read0013690/published_papers/15122649 Suzuyo Okazaki Suetaka Nishiike Hiroshi Watanabe Takao Imai Atsuhiko Uno Tadashi Kitahara Arata Horii Takefumi Kamakura Yasumitsu Takimoto Noriaki Takeda Hidenori Inohara Effects of repeated optic flow stimulation on gait termination in humans. Repeated optic flow caused no significant change of body deviation or the time course of the gait termination process in comparison with that in the control. The walking velocity at the start of the termination process showed short-term flexibility that denoted a gradual increase over the trial for within-set and long-term flexibility that denoted a gradual decrease for between-set. Acta Oto-Laryngologica 1651-2251 133 3 246 252 20131126 10.3109/00016489.2012.740163 23176088 read0013690/published_papers/15122652 Go Sato Kazunori Sekine Kazunori Matsuda Noriaki Takeda Risk factors for poor outcome of a single Epley maneuver and residual positional vertigo in patients with benign paroxysmal positional vertigo Acta Oto-Laryngologica 0001-6489 133 11 1124 1127 20131100 10.3109/00016489.2013.817681 23848235 2-s2.0-84885901223 read0013690/published_papers/15122650 Ryo Kanamura 金村 亮 Masakazu Goda 合田 正和 Hideyuki Nakagawa 神村 盛一郎 Koichi Tamura 中川 英幸 Noriaki Takeda 宇高 二良 Seiichiro Kamimura 田村 公一 Jiro Udaka 武田 憲昭 A case of pyoderma gangrenosum in the nasal root associated with ulcerative colitis 潰瘍性大腸炎に伴う鼻根部壊疽性膿皮症例 Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 106 9 797 802 20130900 10.5631/jibirin.106.797 2-s2.0-84884330292 read0013690/published_papers/15122651 Izumi Chida Koichi Tamura Shin-ichi Nakagawa Masahiro Ando Emi Kuno Hiroshi Hoshikawa Nozomu Mori Noriaki Takeda Clinical outcomes of tracheoesophageal diversion and laryngotracheal separation in neurologically impaired children Auris Nasus Larynx 0385-8146 40 4 383 387 20130800 10.1016/j.anl.2012.11.001 23265577 2-s2.0-84876994848 read0013690/published_papers/15122653 Seiichiro Kamimura 神村 盛一郎 Koji Abe 遠藤 亜紀 Yoshiaki Kitamura 阿部 晃治 Noriaki Takeda 北村 嘉章 Aki Endo 武田 憲昭 An intractable case of MPO-ANCA-associated middle ear disease 難治性MPO-ANCA関連中耳疾患例 Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 106 7 585 589 20130700 10.5631/jibirin.106.585 2-s2.0-84880441097 read0013690/published_papers/15122654 Takao Imai Chisako Masumura Noriaki Takeda Tadashi Kitahara Atsuhiko Uno Arata Horii Suetaka Nishiike Yumi Ohta Kayoko Shingai-Higashi Tetsuo Morihana Suzuyo Okazaki Takefumi Kamakura Yasumitsu Takimoto Hidenori Inohara Pseudo-anterior canalolithiasis. In the patient with true anterior canalolithiasis, the direction of positional nystagmus during reverse Epley maneuver was constant and its axis was perpendicular to the plane of the right ASCC three-dimensionally. In contrast, in the patient with pseudo-anterior canalolithiasis, the first positional nystagmus of which the axis was perpendicular to the plane of the left ASCC became a second positional nystagmus of which the axis was perpendicular to the plane of the right PSCC during the reverse Epley maneuver. Informa UK Limited Acta Oto-Laryngologica 1651-2251 133 6 594 599 20130600 10.3109/00016489.2012.763180 23675810 read0013690/published_papers/15122657 Kazunori Matsuda 松田 和徳 Kazunori Sekine 関根 和教 Gou Satou 佐藤 豪 Haruhiko Shizuku 雫 治彦 Noriaki Takeda 武田 憲昭 Therapeutic effects of diphenidol and betahistine on acute vertigo as determined by the self-assessment of handicap in daily life due to vertigo 急性期のめまいに対するジフェニドールとベタヒスチンの治療効果 患者による日常生活の障害の改善から評価した治療効果の比較 Diphenidol and betahistine are anti-vertigo medications used for the treatment of vertiginous disorders. In the present study, we compared the therapeutic effects of diphenidol and betahistine on the handicap in daily life due to vertigo in patients with acute vertigo. The administration of diphenidol for four weeks significantly decreased the scores for factor 1: handicap in social activities, factor 2: handicap in head movements, factor 3: handicap in body movements, factor 4: handicap in emotion, factor 5: handicap in human interactions and factor 6: handicap due to discomfort. Because diphenidol has both anti-vertigo and anti-emetic actions, these findings suggested that its administration for four weeks recovered the functional handicap associated with factors 2 and 3 and the discomfort handicap of factor 6, resulting in recovery of the social handicap in factors 1 and 5 and emotional handicap (factor 4) in patients with vertigo. On the other hand, the administration of betahistine for four weeks only significantly decreased the scores of factors 1 and 5. This finding suggested that long-term administration of betahistine may be necessary to recover the other factors associated with handicap in patients with vertigo, because betahistine is reported to gradually accelerate the process of vestibular compensation after the development of vestibular asymmetry. 今回，われわれはめまいによりもたらされる日常生活の障害の程度を客観的に評価できるアンケートを用い，ジフェニドールとベタヒスチンの治療効果を比較検討した．ジフェニドールは 4 週間投与で，めまいによる社会活動性の障害，めまいを増悪させる身体の動き(頭位，視覚)，めまいによる身体行動の制限(全般的，体動)，めまいによる感情障害，めまいによる対人関係の障害，めまいによる不快感のすべての因子を有意に改善させた．ジフェニドールは抗めまい作用に加えて制吐作用を持つことから，めまいによる機能障害およびめまいに伴う不快感を改善させ，その結果，めまいによる社会的障害およびめまいによる感情障害を改善させたものと考えられた．ベタヒスチンは 4 週間投与で，めまいによる社会活動性の障害，めまいによる対人関係の障害を有意に改善させたが，その他の因子には有意な改善を認めなかった．薬理作用の点から，ベタヒスチンは 2 カ月以上の長期投与を推奨している報告もあり，めまいにより引き起こされる日常生活の障害に対するベタヒスチンによる効果を明らかにするためには，さらに長期間の投与による検討が必要であると考えられた． Otologia Fukuoka 耳鼻と臨床 0447-7227 59 3 115 121 20130500 10.11334/jibi.59.115 read0013690/published_papers/15122656 Seiichi Nakano 中野 誠一 Eiji Kondo 秋月 裕則 Hironori Akizuki 岩? 英隆 Hidetaka Iwasaki 山下 理子 Satoko Yamashita 藤井 義幸 Yoshiyuki Fujii 近藤 英司 Haruhiko Shizuku 雫 治彦 Koichi Tamura 田村 公一 Noriaki Takeda 武田 憲昭 A case of a laryngocele with recurrent infection 感染を繰り返したlaryngocele例 Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 106 5 439 445 20130500 10.5631/jibirin.106.439 2-s2.0-84878023452 read0013690/published_papers/15122660 高橋 美香 Naoki Toda 戸田 直紀 Noriaki Takeda 武田 憲昭 めまいを伴うHunt症候群における上前庭神経障害 耳鼻咽喉科ニューロサイエンス 27 55 57 20130400 read0013690/published_papers/15122659 Hidetaka Iwasaki Naoki Toda Mika Takahashi Takahiro Azuma Katsuhiko Nakamura Shoichiro Takao Masafumi Harada Noriaki Takeda Vestibular and cochlear neuritis in patients with Ramsay Hunt syndrome: a Gd-enhanced MRI study It is suggested that vertigo in patients with Ramsay Hunt syndrome is mostly induced by superior vestibular neuritis consecutive to the reactivation of varicella-zoster virus (VZV) infection from the geniculate ganglion through the faciovestibular anastomosis. Refractory hearing loss in patients with Ramsay Hunt syndrome may be due to cochlear neuritis following the spread of VZV. An attempt was made to selectively identify vestibulocochlear nerves in the internal auditory canal (IAC) on gadolinium (Gd)-enhanced MRI in patients with Ramsay Hunt syndrome. Fourteen patients with Ramsay Hunt syndrome presenting with facial palsy, herpes zoster oticus, vertigo, and/or sensorineural hearing loss were scanned on 1.5 T MRI enhanced with Gd. Perpendicular section images of the IAC were reconstructed to identify the facial, superior, and inferior vestibular nerves and the cochlear nerves separately. All except one of the patients with Ramsay Hunt syndrome with vertigo showed both canal paresis on the caloric test and Gd enhancement of the superior vestibular nerve in the IAC on MRI. Among 10 patients with hearing loss, 3 patients with severe to moderate sensorineural hearing loss showed Gd enhancement of the cochlear nerve in the IAC on MRI. Acta Oto-Laryngologica 1651-2251 133 4 373 377 20130400 10.3109/00016489.2012.750735 23237095 read0013690/published_papers/15122661 Atsuo Takeichi 武市 充生 Hidetaka Iwasaki 岩? 英隆 Hironori Akizuki 秋月 裕則 Ryo Kanamura 金村 亮 Noriaki Takeda 武田 憲昭 嚥下困難を主訴とした破傷風3例 We report three patients with tetanus who complained of dysphagia. All cases showed trismus, however, physical, serological and endoscopic examinations revealed not abnormalities. Under the diagnosis of tetanus, intravenous penicillin was administered to all three cases, which resulted in the disappearance of trismus, although one case showed a brief episode of generalized convulsion. The diagnosis of tetanus should be suspected in patients complaining of dysphagia who are found to have trismus, but no accompanying endoscopic findings. Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 106 3 229 233 20130300 10.5631/jibirin.106.229 read0013690/published_papers/15122662 Masashi Hattori Hiroyuki Mizuguchi Yuko Baba Shohei Ono Tomohiro Nakano Qian Zhang Yohei Sasaki Makoto Kobayashi Yoshiaki Kitamura Noriaki Takeda Hiroyuki Fukui Quercetin inhibits transcriptional up-regulation of histamine H1 receptor via suppressing protein kinase C-δ/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 signaling pathway in HeLa cells International Immunopharmacology 1567-5769 15 2 232 239 20130200 10.1016/j.intimp.2012.12.030 23333628 2-s2.0-84872759849 read0013690/published_papers/15122930 Izumi Chida 千田 いづみ 島田 亜紀 Jiro Udaka 宇高 二良 佐藤 公美 長嶋 比奈美 Noriaki Takeda 武田 憲昭 Seven-year follow-up of infants born in 2004 in Tokushima with bilateral hearing loss diagnosed without newborn hearing screening 新生児聴覚スクリーニングを受けずに診断された両側難聴児の追跡調査:徳島県で平成16年度に出生した両側難聴児の7年間の経過 Padiatric Otorhinolaryngology Japan 小児耳鼻咽喉科 0919-5858 34 3 345 351 20130000 10.11374/shonijibi.34.345 read0013690/published_papers/15122670 Eiji Kondo 近藤 英司 Ikuji Kawata 川田 育二 Tsukasa Takaishi 高石 司 Ritsuko Abe 阿部 律子 Yoji Hori 堀 洋二 Masakazu Goda 合田 正和 Aki Shimada 島田 亜紀 Noriaki Takeda 武田 憲昭 Role of arteriosclerosis in development of and recovery from sudden deafness and therapeutic effects of lipo-PGE1 突発性難聴における動脈硬化の関与とLipo-PGE1の効果 Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 106 3 203 206 20130000 10.5631/jibirin.106.203 2-s2.0-84874735353 read0013690/published_papers/15122669 高橋 美香 Takahiro Azuma 東 貴弘 Katsuhiko Nakamura 中村 克彦 Noriaki Takeda 武田 憲昭 小児顔面神経麻痺後遺症患者における集団リハビリテーション Facial Nerve Research Japan 0914-790X 33 62 64 20130000 read0013690/published_papers/15122668 Suetaka Nishiike Suzuyo Okazaki Hiroshi Watanabe Hironori Akizuki Takao Imai Atsuhiko Uno Tadashi Kitahara Arata Horii Noriaki Takeda Hidenori Inohara The effect of visual-vestibulosomatosensory conflict induced by virtual reality on postural stability in humans Journal of Medical Investigation 1343-1420 60 3-4 236 239 20130000 10.2152/jmi.60.236 24190041 2-s2.0-84886997901 read0013690/published_papers/15122667 Kumi Sato 佐藤 公美 Jiro Udaka 宇高 二良 Hinami Nagashima 長嶋 比奈美 Kana Morizane 森実 加奈 Miyuki Ito 伊藤 美幸 Yui Goda 合田 侑以 Akiko Ishihara 石原 章子 Noriaki Takeda 武田 憲昭 Correlation between self-voicing and Non-self-voicing, and environmental sound in professional voice abusers -field study using hearing aid with data logging function- 職業的音声酷使者の自己発話と他者発話，環境音との関係 ―補聴器のデータログを用いた検討─ Japan Society of Logopedics and Phoniatrics Japan Journal of Logopedics and Phoniatrics 音声言語医学 0030-2813 54 1 14 19 20130000 10.5112/jjlp.54.14 2-s2.0-84873829931 read0013690/published_papers/15122666 Katsuhiko Nakamura 中村 克彦 高橋 美香 Naoki Toda 戸田 直紀 Takahiro Azuma 東 貴弘 Hidetaka Iwasaki 岩? 英隆 Noriaki Takeda 武田 憲昭 顔面神経麻痺の予後診断とリハビリテーションについて Facial Nerve Research Japan 0914-790X 33 160 162 20130000 read0013690/published_papers/15122665 Takahiro Azuma 東 貴弘 高橋 美香 Naoki Toda 戸田 直紀 Hidetaka Iwasaki 岩? 英隆 Katsuhiko Nakamura 中村 克彦 Noriaki Takeda 武田 憲昭 ボツリヌス投与量を減らしたボツリヌス毒素・ミラーバイオフィードバック併用療法 Facial Nerve Research Japan 0914-790X 33 166 168 20130000 read0013690/published_papers/15122664 Minoru Ikeda 池田 稔 Yuichi Kurono 黒野 祐一 Akira Inokuchi 井之口 昭 Noriaki Takeda 武田 憲昭 Tsunemasa Aiba 愛場 庸雅 Yasuyuki Nomura 野村 泰之 Masafumi Sakagami 阪上 雅史 The effect of zinc agent in 219 patients with zinc deficiency-inductive/ idiopathic taste disorder: A placebo controlled randomized study プラセボ対照無作為化試験による亜鉛欠乏性または特発性味覚障害219例に対するポラプレジンク投与の臨床的検討 Journal of Otolaryngology of Japan 日本耳鼻咽喉科学会会報 0030-6622 116 1 17 26 20130100 10.3950/jibiinkoka.116.17 23484369 2-s2.0-84874276500 read0013690/published_papers/15122663 Tatsuya Fujii 藤井 達也 Masakazu Goda 合田 正和 Kazuhide Mineda 松田 和徳 Noriaki Takeda 宮崎 かつし Kazunori Matsuda 峯田 一秀 Katsushi Miyazaki 中川 宏治 Koji Nakagawa 武田 憲昭 A case of Frey's syndrome after fracture of the mandibular condyle 下顎骨関節突起骨折後に発症したFrey症候群 Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 106 1 13 16 20130100 10.5631/jibirin.106.13 2-s2.0-84872702136 read0013690/published_papers/15122658 Wakana Kuroda Yoshiaki Kitamura Hiroyuki Mizuguchi Yuko Miyamoto Bukasa Kalubi Hiroyuki Fukui Noriaki Takeda Combination of leukotoriene receptor antagonist with antihistamine has an additive suppressive effect on the up-regulation of H1-receptor mRNA in the nasal mucosa of toluene 2,4-diisocyanate-sensitized rat Journal of Pharmacological Sciences 1347-8613 122 1 55 58 20130000 10.1254/jphs.12250SC 23615224 2-s2.0-84878131133 read0013690/published_papers/15122671 Hiroyuki Mizuguchi Kohei Miyagi Takuma Terao Noriko Sakamoto Yosuke Yamawaki Tsubasa Adachi Shohei Ono Yohei Sasaki Yoshiyuki Yoshimura Yoshiaki Kitamura Noriaki Takeda Hiroyuki Fukui PMA-induced dissociation of Ku86 from the promoter causes transcriptional up-regulation of histamine H-1 receptor SCIENTIFIC REPORTS 2045-2322 2 916 916 20121200 10.1038/srep00916 23209876 read0013690/published_papers/15122673 高橋 美香 Naoki Toda 戸田 直紀 Takahiro Azuma 東 貴弘 Hidetaka Iwasaki 岩? 英隆 Katsuhiko Nakamura 中村 克彦 Noriaki Takeda 武田 憲昭 Hunt症候群における内耳道造影MRIについて Facial Nerve Research Japan 0914-790X 32 113 115 20121100 read0013690/published_papers/15122672 Takahiro Azuma 東 貴弘 Hidetaka Iwasaki 岩? 英隆 Naoki Toda 戸田 直紀 Katsuhiko Nakamura 中村 克彦 Noriaki Takeda 武田 憲昭 発症した病的共同運動に対するボツリヌス毒素・ミラーフィードバック併用療法の長期成績 Facial Nerve Research Japan 0914-790X 32 68 70 20121100 read0013690/published_papers/15122674 Takao Imai Noriaki Takeda Atsuhiko Uno Arata Horii Tadashi Kitahara Suetaka Nishiike Kayoko Higashi-Shingai Hidenori Inohara Benign paroxysmal positional vertigo showing sequential translations of four types of nystagmus Auris Nasus Larynx 0385-8146 39 5 544 548 20121000 10.1016/j.anl.2011.10.007 22088257 2-s2.0-84861823654 read0013690/published_papers/15122675 Osamu Jinnouchi Tomomi Kuwahara Shiro Ishida Yoshiro Okano Yasuko Kasei Kazufumi Kunitomo Noriaki Takeda Anti-microbial and therapeutic effects of modified Burow's solution on refractory otorrhea Auris Nasus Larynx 0385-8146 39 4 374 377 20120800 10.1016/j.anl.2011.07.007 21862264 2-s2.0-84860310688 read0013690/published_papers/15122676 Junya FUKUDA 福田 潤弥 Masakazu Goda 合田 正和 Chisa Fujimoto 藤本 知佐 Tetsuo IKEZONO 池園 哲郎 Takashi NAKAGAWA 中川 尚志 Hiroshi HIBINO 日比野 浩 Yoshiaki Kitamura 北村 嘉章 Koji Abe 阿部 晃治 Koichi Tamura 田村 公一 Noriaki Takeda 武田 憲昭 A case of suspected perilymphatic oozer with CTP-positive cerebrospinal otorrhea Perilymphatic oozer が疑われたCTP陽性の耳性髄液漏症例 (一社)日本耳科学会 Otology Japan 1884-1457 22 3 274 279 20120725 10.11289/otoljpn.22.274 read0013690/published_papers/15122684 Nobuko Sarukura Shinji Takai Shinji Ikemoto Tomoo Korin Yukiko Ueda Yoshiaki Kitamura Bukasa Kalubi Shigeru Yamamoto Noriaki Takeda Effects of dietary zinc deprivation on zinc concentration and ratio of apo/holo-activities of angiotensin converting enzyme in serum of mice Auris Nasus Larynx 0385-8146 39 3 294 297 20120600 10.1016/j.anl.2011.05.007 21862265 2-s2.0-84859732125 read0013690/published_papers/15122679 Cisa Fujimoto Noriaki Takeda A Matsunaga A Sawada T Tanaka Takashi Kimoto Wakako Shinahara Takako Sawabuchi Miyoko Yamaguchi M Hayama Hiroaki Yanagawa Mihiro Yano Hiroshi Kido Induction and maintenance of anti-influenza antigen-specific nasal secretory IgA levels and serum IgG levels after influenza infection in adults. To determine the induction and changes in anti-influenza virus secretory IgA (s-IgA) levels in nasal washes and serum IgG levels in patients with influenza. The study recruited 16 patients with influenza aged 35.6 ± 9.6 years in 2007/2008 and 2008/2009 seasons. Nasal washes and serum were obtained throughout the first year. Anti-viral s-IgA levels and neutralization activities in nasal washes, and serum anti-viral IgG levels and hemagglutination inhibition (HI) titers were measured. Anti-viral(H1N1) s-IgA to total IgA ratio and neutralizing antibody titer were low in nasal washes of all patients, whereas serum levels of anti-viral IgG and HI titers varied widely at day 1.4 ± 1.0 postinfection. Both nasal s-IgA and serum IgG levels later increased significantly, reaching peak levels at day 9.6 ± 3.3 postinfection. The induced nasal s-IgA then returned toward the initial levels within 300 days, although the levels at day 143 ± 70 were 3.03-fold of the initial. Individual serum IgG levels also returned toward the initial levels within 300 days, although the mean levels remained high probably because of re-infection in a subgroup of patients. Although influenza A (H3N2) was a minor epidemic subtype in both flu seasons, a significant rise in nasal anti-viral (H3N2) s-IgA levels and a slightly increase in serum IgG levels were noted. Low levels of nasal anti-viral s-IgA and neutralizing antibody were noted compared with a wide range of serum anti-viral IgG and HI titers at the onset of infection. Elevated s-IgA and IgG returned toward the initial levels within 300 days of infection with minor exceptions. Influenza and Other Respiratory Viruses 1750-2659 6 6 396 403 20120600 10.1111/j.1750-2659.2011.00330.x 22226319 read0013690/published_papers/15122678 Gou Satou Kazunori Sekine Kazunori Matsuda Noriaki Takeda Effects of sleep position on time course in remission of positional vertigo in patients with benign paroxysmal positional vertigo. The side of the affected ear was significantly associated with the head-lying side during sleep in patients with P-BPPV and was closely but not significantly associated with it in patients with H-BPPV. However, the head-lying side during sleep did not affect the remission rate of their positional vertigo. Acta Oto-Laryngologica 1651-2251 132 6 614 617 20120600 10.3109/00016489.2012.655860 22384815 read0013690/published_papers/15122677 Mie Shimatani 島谷 美映 Izumi Chida 宇高 二良 Aki Shimada 島谷 佳光 Koichi Tamura 千田 いづみ Noriaki Takeda 島田 亜紀 Jiro Udaka 田村 公一 Yoshimitsu Shimatani 武田 憲昭 A case of tetanus associated with dysphagia 嚥下障害を主訴とした破傷風例 Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 105 6 571 575 20120601 10.5631/jibirin.105.571 2-s2.0-84862659981 read0013690/published_papers/15122682 Kayoko Higashi-Shingai Takao Imai Noriaki Takeda Atsuhiko Uno Suetaka Nishiike Arata Horii Tadashi Kitahara Yuka Fuse Misako Hashimoto Osamu Senba Tsuyoshi Suzuki Toshiaki Fujita Hideo Otsuki Hidenori Inohara 3D analysis of spontaneous upbeat nystagmus in a patient with astrocytoma in cerebellum Auris Nasus Larynx 0385-8146 39 2 216 219 20120400 10.1016/j.anl.2011.03.005 21602005 2-s2.0-84856693285 read0013690/published_papers/15122681 Yoshiaki Kitamura Hiroyuki Mizuguchi Hirotaka Ogishi Wakana Kuroda Masashi Hattori Hiroyuki Fukui Noriaki Takeda Preseasonal prophylactic treatment with antihistamines suppresses IL-5 but not IL-33 mRNA expression in the nasal mucosa of patients with seasonal allergic rhinitis caused by Japanese cedar pollen. These findings suggest that the down-regulation of interleukin (IL)-5 gene expression in collaboration with the suppression of histamine H(1) receptor (H1R) gene expression in the nasal mucosa provides the basis for better therapeutic effects of preseasonal prophylactic treatment with antihistamines in patients with seasonal allergic rhinitis caused by Japanese cedar pollen. The effects of prophylactic administration of antihistamines on the expression of IL-5 and IL-33 mRNA in the nasal mucosa of the patients with pollinosis were investigated. Eight patients had already visited the hospital before the peak pollen period and started preseasonal prophylactic treatment with antihistamines. Seventeen patients who first visited the hospital during the peak pollen period were designated as the no treatment group. After local anesthesia, nasal mucosa was obtained by scraping the inferior concha with a small spatula during the peak pollen period. During the peak pollen period, the expression of IL-5 mRNA, but not that of IL-33 mRNA, in the nasal mucosa of patients receiving preseasonal prophylactic treatment with antihistamines was significantly lower in comparison with that of patients without treatment. Moreover, there was a significant correlation between the expression of IL-5 mRNA and the nasal symptoms or the expression of H1R mRNA. Acta Oto-Laryngologica 1651-2251 132 4 434 438 20120400 10.3109/00016489.2011.644804 22216765 read0013690/published_papers/15122680 Kazunori Matsuda 松田 和徳 Ikuji Kawata 川田 育二 Ritsuko Abe 阿部 律子 Yoshiaki Kitamura 北村 嘉章 Kazunori Sekine 関根 和教 Koji Abe 阿部 晃治 Koich Tamura 田村 公一 Noriaki Takeda 武田 憲昭 Effects of oral administration of prostaglandin 12 as a salvage treatment in patients with sudden deafness 突発性難聴難治例に対するプロスタグランディンI2製剤を用いた二次治療の検討 Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 105 4 375 379 20120400 10.5631/jibirin.105.375 2-s2.0-84859751092 read0013690/published_papers/15122683 Arata Horii Aya Nakagawa Atsuhiko Uno Tadashi Kitahara Takao Imai Suetaka Nishiike Noriaki Takeda Hidenori Inohara Implication of substance P neuronal system in the amygdala as a possible mechanism for hypergravity-induced motion sickness Brain Research 0006-8993 1435 91 98 20120130 10.1016/j.brainres.2011.11.047 22192410 2-s2.0-84856403284 read0013690/published_papers/15122931 Noriaki Takeda 武田 憲昭 MPO-ANCA関連中耳疾患の取り扱い The Oto-Rhino-Laryngological Society of Japan, Inc. Journal of Otolaryngology of Japa 日本耳鼻咽喉科学会会報 0030-6622 115 10 932 933 20120000 10.3950/jibiinkoka.115.932 read0013690/published_papers/15122686 Noriaki Takeda 武田 憲昭 MPO-ANCA陽性の難治性中耳炎と顔面神経障害 Facial Nerve Research Japan 0914-790X 31 29 30 20111200 read0013690/published_papers/15122685 高橋 美香 Takahiro Azuma 東 貴弘 Katsuhiko Nakamura 中村 克彦 Hidetaka Iwasaki 岩? 英隆 Naoki Toda 戸田 直紀 Noriaki Takeda 武田 憲昭 顔面神経麻痺患者に対する集団リハビリテーション Facial Nerve Research Japan 0914-790X 31 148 150 20111200 read0013690/published_papers/15122689 Islam Mohammed Nurul Hiroyuki Mizuguchi Masum Shahriar Pichairajan Venkatesh Kazutaka Maeyama Pulok K. Mukherjee Masashi Hattori Mohamed Sahabuddin Kabir Choudhuri Noriaki Takeda Hiroyuki Fukui Albizia lebbeck suppresses histamine signaling by the inhibition of histamine H 1 receptor and histidine decarboxylase gene transcriptions International Immunopharmacology 1567-5769 11 11 1766 1772 20111100 10.1016/j.intimp.2011.07.003 21782040 2-s2.0-80054978051 read0013690/published_papers/15122687 川田 仁美 Izumi Chida 千田 いづみ Kazunori Matsuda 松田 和徳 Gou Satou 佐藤 豪 Seizo Oyama 大山 晴三 石谷 保夫 Noriaki Takeda 武田 憲昭 小児の中耳奇形腫例 We report a case of infantile middle-ear teratoma. A 6-month-old girl was first seen and reported to have a history of refractory left-ear otitis media. Computed tomography (CT) and magnetic resonance imaging (MRI) showed a tumor occupying the tympanic cavity and eustachian tube. The tumor, was biopsied twice transaural, under general anesthesia, contained squamous epithelium, striated muscle, and adipose tissue, suggesting middle-ear teratoma. The tumor was resected completely in canal wall tympanoplasty with mastoidectomy under general anesthesia. Histologically, the heterogeneous tumor consisted of tissues including squamous epithelium, sebaceous gland and hair follicle, skin appendages, adipose tissue, striated muscle, cartilage, minor salivary-gland-like tissue, and bone. Mature middle-ear teratoma was diagnosed due to the absence of immaturity and malignancy. The girl remains recurrence-free in the 3 years since surgery. Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 104 10 689 695 20111001 10.5631/jibirin.104.689 read0013690/published_papers/15122690 Hiroyuki Mizuguchi Takuma Terao Mika Kitai Mitsuhiro Ikeda Yoshiyuki Yoshimura Asish Kumar Das Yoshiaki Kitamura Noriaki Takeda Hiroyuki Fukui Involvement of protein kinase Cδ/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 (PARP-1) signaling pathway in histamine-induced up-regulation of histamine H 1 receptor gene expression in HeLa cells Journal of Biological Chemistry 0021-9258 286 35 30542 30551 20110902 10.1074/jbc.M111.253104 21730054 2-s2.0-80052248531 read0013690/published_papers/15122688 Nobuko Sarukura Miho Kogirima Shinji Takai Yoshiaki Kitamura Bukasa Kalubi Shigeru Yamamoto Noriaki Takeda Dietary zinc intake and its effects on zinc nutrition in healthy Japanese living in the central area of Japan. In the present study, we first examined the dietary zinc intake from food groups in 109 healthy Japanese (24-82 years old, 45 male and 64 female) by means of the 72-h recall method. We then used the ratio of apo/holo-activities of angiotensin converting enzyme (ACE ratio) that is a more sensitive index of zinc nutrition than zinc concentration in the serum and examined the correlation between their zinc intake and ACE ratio. Dietary zinc intake in healthy Japanese was maximal from rice and rice products. There were significant inverse correlations between the ACE ratio and dietary zinc intake from rice and rice products and shellfish, and a significant positive correlation between ACE ratio and dietary zinc intake from other beans and bean processed foods. On the other hand, there were no significant correlations between serum zinc concentrations and dietary zinc intake from any food group except processed fish. These findings suggested that rice is a major source of dietary zinc intake in healthy Japanese. It is also suggested that shellfish also has a major impact on zinc nutrition, although dietary zinc intake from this source is minimal. Since beans contain phytic acid, which inhibits the absorption of dietary zinc, it is suggested that intake of beans causes impairment of zinc nutrition. The Journal of Medical Investigation : JMI 1349-6867 58 3-4 203 209 20110800 10.2152/jmi.58.203 21921421 read0013690/published_papers/15122692 Noriaki Takeda 武田 憲昭 神村 盛一郎 Izumi Chida 千田 いづみ Yoshiaki Kitamura 北村 嘉章 Osamu Jinnouchi 陣内 自治 Koji Abe 阿部 晃治 Koichi Tamura 田村 公一 Jiro Udaka 宇高 二良 Aki Endo 遠藤 亜紀 感音難聴と顔面神経麻痺を示すMPO-ANCA関連中耳疾患の1例 診断基準案の提案 We reported a case of MPO-ANCA-associated middle ear disease with sensorineural hearing loss and facial palsy. A 62-year-old female first complained of bilateral aural obstruction and the treatment for otitis media with effusion was ineffective. Then, bilateral sensorineural hearing loss developed, and after the transient effect of steroid therapy, left facial palsy appeared. CT demonstrated that the low density area in the middle ear cavity without bone destruction, and its granular tissue surgically resected showed non-specific findings by the histopathological examination. MPO-ANCA was positive, but PR3-ANCA was negative in the serum without pulmonary and renal lesions. Steroid treatment with cyclophosphamaide improved the hearing loss and facial palsy with a decrease of serum MPO-ANCA level.<br> Although it was reported previously that patients with MPO-ANCA-associated middle ear disease with sensorineural hearing loss and facial palsy were successfully treated by combination therapy with steroid and immunosuppressive drug in addition to our case, they could not meet the criteria of ANCA-associated vasculitides such as Wegener's glanulomatosis. Therefore, we proposed the diagnostic term and criteria of MPO-ANCA-associated middle ear disease with sensorineural hearing loss and facial palsy. The underlying pathophysiology of this disease may be MPO-ANCA-induced vasculitis, but review of literature showed that its clinical characteristics are different from those of ANCA-associated vasculitides.<br>The proposed diagnostic criteria were as follows: 1) the onset of otitis media-like symptom, 2) progressed sensorineural hearing loss, 3) complicating facial palsy, 4) lesion limited to the middle ear without pulmonary and renal lesions, 5) MPO-ANCA positive, but PR3-ANCA negative in the serum, 6) no findings of vasculitis in the middle ear lesion. 感音難聴と顔面神経麻痺を示したMPO-ANCA関連中耳疾患症例を報告した．耳閉感で初発し，滲出性中耳炎の治療を受けるも両感音難聴が進行した．ステロイドの効果は一時的であり，その後，左顔面神経麻痺が出現した．側頭骨CTでは中耳に軟部陰影を認めたが，骨破壊なし．PR3-ANCA陰性，MPO-ANCA陽性であったが，肺・腎病変はなく，中耳組織に血管炎の所見を認めなかった．ステロイドと免疫抑制薬の投与により，難聴と顔面神経麻痺は改善した．このような感音難聴と顔面神経麻痺を示すMPO-ANCA関連中耳疾患は，MPO-ANCAによる血管炎が関与している可能性があるが，組織検査でANCA関連血管炎と診断できない．また，本疾患はANCA関連血管炎とは臨床的特徴が異なっていた．本疾患はステロイドと免疫抑制薬の併用治療が有効であるため，免疫抑制剤の使用の根拠となる診断名が必要と考え，診断基準とともに提案した． THE JAPAN OTOLOGICAL SOCIETY Otology Japan 0917-2025 21 5 808 815 20110500 10.11289/otoljpn.21.808 read0013690/published_papers/15122691 Seiichi Nakano 中野 誠一 Haruhiko Shizuku 雫 治彦 Hironori Akizuki 秋月 裕則 Hidetaka Iwasaki 岩? 英隆 Koichi Shichijou 七條 光市 Takeshi Ogose 生越 剛司 Tsutomu Watanabe 渡邉 力 Tadanori Nakatsu 中津 忠則 Noriaki Takeda 武田 憲昭 Periodic fever with aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome, an autoinflammatory disease treated with tonsillectomy 扁摘が有効であった自己炎症疾患PFAPA症候群例 Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 104 5 347 352 20110500 10.5631/jibirin.104.347 2-s2.0-79957449630 read0013690/published_papers/15122693 Kana Morizane 森実 加奈 Kumi Satou 佐藤 公美 Akane Mineoi 三根生 茜 Yui Goda 合田 侑以 Hinami Nagashima 長嶋 比奈美 Jiro Udaka 宇高 二良 Noriaki Takeda 武田 憲昭 The importance of language disorder screening in school medical examinations 学校健診における言語障害検診の重要性 Japan Journal of Logopedics and Phoniatrics 音声言語医学 0030-2813 52 2 183 188 20110400 10.5112/jjlp.52.183 2-s2.0-79955794956 read0013690/published_papers/15122696 Noriaki Takeda Mahito Ito Hidenori Inohara Natural course of positional vertigo in patients with apogeotropic variant of horizontal canal benign paroxysmal positional vertigo. OBJECTIVE: The purpose of this study was to assess the natural course of positional vertigo in patients with the apogeotropic variant of horizontal canal type of benign paroxysmal positional vertigo (AH-BPPV), which is reported to be more refractory to physiotherapy than the geotropic variant of horizontal canal type of BPPV (GH-BPPV). METHODS: 14 patients with AH-BPPV treated without physiotherapy were asked to visit the hospital every 2 weeks. At every follow-up visit, they were interviewed and positional nystagmus was assessed. After the disappearance of positional nystagmus, patients were asked about the time of cessation of the positional vertigo. Thus, the primary outcomes were evaluated by the self-reported onset and remission of positional vertigo. The time course of remission of positional vertigo was then calculated. RESULTS: The average and median period from the onset to natural remission of positional vertigo in patients with AH-BPPV was 13 and 7 days, respectively. CONCLUSION: We have already reported that the average and median period from the onset to natural remission of positional vertigo in patients with GH-BPPV was 16 and 7 days, respectively (Imai et al., 2005 [8]). Thus, the natural course of AH-BPPV is not as refractory as that of GH-BPPV. Auris, Nasus, Larynx 1879-1476 38 1 2 5 20110200 10.1016/j.anl.2010.05.011 20591594 read0013690/published_papers/15122695 Hiroyuki Mizuguchi 水口 博之 Yoshiaki Kitamura 北村 嘉章 Yuto Kondo 近藤 勇人 Wakana Kuroda 黒田 若奈 Haruka Yoshida 吉田 陽香 Yuko Miyamoto 宮本 裕子 Masashi Hattori 服部 将史 Noriaki Takeda 武田 憲昭 Hiroyuki Fukui 福井 裕行 ヒスタミンH1受容体遺伝子発現機構のアレルギー疾患における病理学的意義 Therapeutics targeting disease-sensitive genes are required for the therapy of multifactorial diseases. There is no clinical report on therapeutics for allergic disease-sensitive genes. We are focusing on the histamine H1 receptor (H1R) as a sensitive gene. H1R mediates allergy histamine signals. H1R is a rate-limiting molecule of the H1R signal because the signal is increased with elevated receptor expression level. We discovered that the stimulation of H1R induced H1R gene expression through PKCδ activation, resulting in receptor upregulation. The mechanism of H1R gene expression was revealed to play a key role in the receptor expression level in studies using cultured HeLa cells and allergic rhinitis model rats. Preseasonal prophylactic treatment with antihistamines is recommended for the therapy of pollinosis. However, the mechanism of the therapy remains to be elucidated. We demonstrated that repeated pretreatment treatment with antihistamines in the allergic rhinitis model rats resulted not only in improvement of symptoms but also in suppressed elevation of H1R mRNA levels in the nasal mucosa. A clinical trial was then initiated. When symptoms and H1R mRNA levels in the nasal mucosa of pollinosis patients with or without preseasonal prophylactic treatment with antihistamines were examined, both symptoms and high levels of H1R mRNA were significantly improved in treated compared with untreated patients. These results strongly suggest that H1R is an allergic disease-sensitive gene. Journal of the Pharmaceutical Society of Japan 薬学雑誌 0031-6903 131 2 171 178 20110200 10.1248/yakushi.131.171 read0013690/published_papers/15122694 Hideyuki Nakagawa 中川 英幸 Yoji Hori 堀 洋二 Seizo Oyama 大山 晴三 Koichi Tamura 田村 公一 Noriaki Takeda 武田 憲昭 Kazunori Matsuda 松田 和徳 Chemosurgery with Mohs' paste improves terminal recurrent maxillary cancer QOL Mohs 軟膏を用いた chemosurgery で緩和ケアを行った上顎洞癌末期例 Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 104 3 187 191 20110000 10.5631/jibirin.104.187 2-s2.0-79953138037 read0013690/published_papers/15122697 中山 壽孝 Yoshiaki Kitamura 北村 嘉章 Noriaki Takeda 武田 憲昭 徳島県における過去26年間のヒノキ科花粉の飛散状況 徳島県におけるヒノキ科花粉の飛散状況を1981年から2007年までの26年間測定した．1)ヒノキ科花粉の総飛散数はスギ花粉の総飛散数の3割以下であった．両者の花粉の飛散総数の変化はほぼ一致したが，両者の比率は年によって異なっており，ヒノキ科花粉の独自の飛散予報も必要と考えられた．2)スギ花粉の飛散総数は前年7月の最高気温，平均気温，日照時間との間に有意な正の相関がみられ，湿度との間に有意な負の相関が認められたが，降水量との間に相関は確認されなかった．一方，ヒノキ科花粉の飛散総数は前年7月の最高気温，平均気温との間にのみ相関が認められた．3)ヒノキ科花粉の飛散総数に影響する，スギ花粉とは異なる気象因子の解明が必要であると考えられた．すなわちヒノキ科花粉の飛散期間は3月下旬から4月下旬でスギ花粉飛散期間よりも約1ヵ月遅かった．尚，両花粉は共通抗原性を持つため，ヒノキ科花粉がスギ花粉症患者の症状遷延化や増悪の一因となっていると考えられた． Japanese Journal of Rhinology 日本鼻科学会会誌 0910-9153 49 4 474 480 20101210 10.7248/jjrhi.49.474 read0013690/published_papers/15122702 H. Mizuguchi Y. Kitamura Y. Kondo W. Kuroda H. Yoshida Y. Miyamoto M. Hattori H. Fukui N. Takeda PRESEASONAL PROPHYLACTIC TREATMENT WITH ANTIHISTAMINES SUPPRESSES NASAL SYMPTOMS AND EXPRESSION OF HISTAMINE H-1 RECEPTOR mRNA IN THE NASAL MUCOSA OF PATIENTS WITH POLLINOSIS METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY 0379-0355 32 10 745 748 20101200 10.1358/mf.2010.32.10.1533687 21225011 read0013690/published_papers/15122701 Katsuhiko Nakamura 中村 克彦 高橋 美香 Naoki Toda 戸田 直紀 Takahiro Azuma 東 貴弘 Hidetaka Iwasaki 岩? 英隆 Seizo Oyama 大山 晴三 Noriaki Takeda 武田 憲昭 完全脱神経を来たしたHumt症候群に対するリハビリテーション Facial Nerve Research Japan 0914-790X 30 137 139 20101200 read0013690/published_papers/15122700 Naoki Toda 戸田 直紀 高橋 美香 Takahiro Azuma 東 貴弘 Hidetaka Iwasaki 岩? 英隆 Katsuhiko Nakamura 中村 克彦 Noriaki Takeda 武田 憲昭 Hunt症候群における聴力障害の検討 Facial Nerve Research Japan 0914-790X 30 75 77 20101200 read0013690/published_papers/15122699 高橋 美香 Naoki Toda 戸田 直紀 Takahiro Azuma 東 貴弘 Hidetaka Iwasaki 岩? 英隆 Katsuhiko Nakamura 中村 克彦 Noriaki Takeda 武田 憲昭 上前庭神経障害によるめまいと考えられた不完全Hunt症候群症例 Facial Nerve Research Japan 0914-790X 30 179 180 20101200 read0013690/published_papers/15122698 H. Umehara H. Mizuguchi N. Mizukawa M. Matsumoto N. Takeda E. Senba H. Fukui INNERVATION OF HISTAMINE NEURONS IN THE CAUDAL PART OF THE ARCUATE NUCLEUS OF HYPOTHALAMUS AND THEIR ACTIVATION IN RESPONSE TO FOOD DEPRIVATION UNDER SCHEDULED FEEDING METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY 0379-0355 32 10 733 736 20101200 10.1358/mf.2010.32.10.1545781 21225009 read0013690/published_papers/15122703 Hideo Shojaku Yukio Watanabe Noriaki Takeda Tetsuo Ikezono Masahiro Takahashi Akinobu Kakigi Juichi Ito Katsumi Doi Mamoru Suzuki Masaya Takumida Katsumasa Takahashi Hiroshi Yamashita Izumi Koizuka Shinichi Usami Mitsuhiro Aoki Hideaki Naganuma Clinical characteristics of delayed endolymphatic hydrops in Japan: A nationwide survey by the Peripheral Vestibular Disorder Research Committee of Japan. CONCLUSION: Similarly to almost all delayed endolymphatic hydrops (DEH) cases with both precedent sudden deafness and mumps deafness, two-thirds of DEH cases with precedent deafness of unknown cause with onset in early childhood developed DEH symptoms within 40 years after the precedent deafness. In spite of the diagnosis of precedent deafness, viral labyrinthitis may build up the late endolymphatic hydrops in most DEH cases up to four decades. OBJECTIVE: To clarify the characteristics of DEH in Japan. METHODS: Clinical information on 198 DEH cases was collected by nationwide, multicenter surveys conducted by the Peripheral Vestibular Disorders Research Committee of Japan. RESULTS: The incidence of the ipsilateral type of DEH was 47.5%, which was almost equal to that of the contralateral type. In both types of DEH, the most common diagnosis of precedent deafness was deafness of unknown cause with onset in early childhood: 43.9% in both types of DEH. Sudden deafness and mumps deafness were the subsequent diagnoses of precedent deafness. The distribution of time delay of the onset between precedent deafness of unknown cause with onset in early childhood and DEH was different from that between precedent sudden and mumps deafness and DEH. Acta oto-laryngologica 1651-2251 130 10 1135 40 20101000 10.3109/00016481003745543 20441535 read0013690/published_papers/15122704 Yoshiaki Kitamura 北村 嘉章 黒田 若奈 Hiroyuki Mizuguchi 水口 博之 Hiroyuki Fukui 福井 裕行 Noriaki Takeda 武田 憲昭 スギ花粉症における初期療法の作用機序の検討 Japanese Journal of Rhinology 日本鼻科学会会誌 0910-9153 49 3 375 375 20100700 read0013690/published_papers/15122705 Takao Imai Arata Horii Noriaki Takeda Tadashi Kitahara Kayoko Higashi-Shingai Hidenori Inohara A case of apogeotropic nystagmus with brainstem lesion: An implication for mechanism of central apogeotropic nystagmus. We report a case showing apogeotropic nystagmus with the lesion of the brain stem, and discuss a possible mechanism of central apogeotropic nystagmus. The case was a 73-year-old male. We analyzed his nystagmus three-dimensionally. He showed apogeotropic nystagmus. Axis angles of slow phase eye velocity of his apogeotropic nystagmus were not in line with the axes perpendicular to the plane of horizontal semicircular canals, but with the patient&amp;apos;s vertical axis. We then found that his nystagmus including the apogeotropic nystagmus was positioning, but not positional and that the direction of his positioning nystagmus was the same direction of postrotatory nystagmus after his head movement. His MRI scans showed an infarction around the prepositus hypoglossi nucleus of the brain. His apogeotropic nystagmus seemed to consist of a combination of prolonged postrotatory nystagmus after his head rotation to the left and right lateral position because the axis of postrotatory nystamus was in line with the axis of the head rotation. Therefore, it is suggested that a possible mechanism of central apogeotropic nystagmus is a prolonged postrotatory nystagmus after his head movement in the supine position due to the brain lesion involving the velocity storage mechanisms. Auris, Nasus, Larynx 1879-1476 37 6 742 746 20100626 10.1016/j.anl.2010.04.004 20580172 read0013690/published_papers/15122708 Tsukasa Takaoka Nobuko Sarukura Chizuru Ueda Yoshiaki Kitamura Bukasa Kalubi Naoki Toda Koji Abe Shigeru Yamamoto Noriaki Takeda Effects of zinc supplementation on serum zinc concentration and ratio of apo/holo-activities of angiotensin converting enzyme in patients with taste impairment. OBJECTIVE: The aim of the present study was to evaluate the effects of zinc supplementation on hypogeusia, serum zinc concentration and the ratio of apo/holo-activities of angiotensin converting enzyme (ACE ratio) in patients with taste impairment. ACE ratio was used as an index of zinc nutritional status. METHODS: Forty patients complaining of taste impairment were divided into two groups: zinc deficiency taste impairment (n=12) and idiopathic taste impairment (n=28). Patients with zincemia values of less than 63 microg/dl with no history of other disorder or medication known to cause dysgeusia were diagnosed as zinc deficiency group, while those with the same condition and values more than 64 microg/dl were considered to belong to the idiopathic group. Patients orally received 150 mg of polaprezinc containing 33 mg of zinc every day. Subjective symptom was scored according to visual analogue scale (VAS). RESULTS: Zinc supplementation improved hypogeusia in both idiopathic and zinc deficiency groups. The mean improvements of VAS were 3.02+/-3.03 in the idiopathic group and 3.13+/-2.53 in the zinc deficiency group. Thus, there were no significant differences in idiopathic and zinc deficiency groups. Significant correlations were found between the improvement of VAS score and the ACE ratio after zinc supplementation in both idiopathic and zinc deficiency groups. On the contrary, significant correlations were not found between the improvement of VAS score and the zinc concentration in the serum after zinc supplementation in both groups. CONCLUSION: The results of the present study indicated that zinc deficiency is a predominant factor underlying taste impairment and ACE ratio may be a predictor of the prognosis for taste impairment after zinc supplementation, in addition to a more sensitive indicator of zinc nutrition than zinc concentration in the serum. Auris, Nasus, Larynx 1879-1476 37 2 190 194 20100400 10.1016/j.anl.2009.07.003 19716667 read0013690/published_papers/15122707 Noriaki Takeda 武田 憲昭 Zinc deficiency in patients with idiopathic taste impairment from the view point of ratio of apo/holo-activities of angiotensin converting enzyme as an index. 【亜鉛酵素・トランスポーター研究の最前線】 亜鉛酵素「アンギオテンシン変換酵素」活性比を用いた味覚障害患者の亜鉛栄養状態の評価 日本微量元素学会 Biomedical Research on Trace Elements 0916-717X 21 1 32 37 20100401 10.11299/brte.21.32 read0013690/published_papers/15122712 Noriaki Takeda 武田 憲昭 【めまいのup date】 めまい疾患の診断と治療 メニエール病 Clinician クリニシアン 0387-1541 57 3 248 253 20100300 read0013690/published_papers/15122711 Kazunori Sekine 関根 和教 松田 和徳 Gou Satou 佐藤 豪 Noriaki Takeda 武田 憲昭 アルコール性頭位眼振の3次元主軸解析 厚生労働省 難治性疾患克服事業 前庭機能異常に関する調査研究班 平成21年度報告書 142 145 20100300 read0013690/published_papers/15122710 松田 和徳 Kazunori Sekine 関根 和教 Gou Satou 佐藤 豪 Haruhiko Shizuku 雫 治彦 Tetsuya Uemura 植村 哲也 Noriaki Takeda 武田 憲昭 急性期のめまいに対するジフェニドールとベタヒスチンの効果:日常生活障害度の改善の評価 厚生労働省 難治性疾患克服研究事業 前庭機能異常に関する調査研究班 平成21年度報告書 164 168 20100300 read0013690/published_papers/15122709 長嶋 比奈美 Izumi Chida 千田 いづみ 島田 亜紀 Noriaki Takeda 武田 憲昭 吃音児への早期介入の効果 3ヵ月以上の言語指導期間のある18歳未満の吃音児57名を対象に,介入時期と吃音の改善効果について検討した．紹介元では,他機関の専門職からの紹介が59 Padiatric Otorhinolaryngology Japan 小児耳鼻咽喉科 0919-5858 31 1 71 75 20100301 10.11374/shonijibi.31.71 read0013690/published_papers/15122713 Kazunori Sekine 関根 和教 Takao Imai 今井 貴夫 Fumitoshi Tachibana 立花 文寿 Kazunori Matuda 松田 和徳 Go Sato 佐藤 豪 Noriaki Takeda 武田 憲昭 A case of Costen's syndrome with chewing-induced vertigo 咀嚼によりめまいが誘発されたCosten症候群症例 Japan Society for Equilibrium Research Equilibrium Research 0385-5716 69 1 47 51 20100000 10.3757/jser.69.47 2-s2.0-77949823310 read0013690/published_papers/15122706 Takuma Sekita 関田 拓馬 Akio Kondo 近藤 昭男 Noriaki Takeda 武田 憲昭 Palliative treatment with Mohs' paste for unresectable cervical lymph node metastasis in hypopharyngeal carcinoma Mohs軟膏によりQOLを改善しえた下咽頭癌の手術不能頸部リンパ節転移例 Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 103 6 587 590 20100000 10.5631/jibirin.103.587 2-s2.0-77953790542 read0013690/published_papers/15122715 Koichi Tamura Kim Masanobu Koji Abe Naoki Toda Osamu Jinnouchi Bukasa Kalubi Noriaki Takeda A new video laryngo-pharyngoscope with shape-holding coiled tube and surgical forceps: a preliminary study We developed a new video laryngo-pharyngoscope with a shape-holding coiled tube and examined its effectiveness in some patients. The video laryngo-pharyngoscope is designed to inspect the pharynx and larynx transorally and to perform surgical manipulations. The scope consists of a coiled tube, a grip with trigger connected to the forceps and a CCD Camera with a battery. The stainless coiled tube of the scope is flexible but shape-holding, so that its shape can be changed by hand with the characteristic that the new orientation remains invariable during both inspection and operation in the pharynx and larynx. After a local anesthesia, the operator holds the scope in one hand and pulls the patient&#039;s tongue by the other hand. The operator then inserted the scope transorally while monitoring video images that were wirelessly transferred to the display to ensure that the forceps has reached the area of interest and treated lesions successfully. Using the scope, we successfully examined the upper airway lesions and removed foreign bodies from the pharynx and performed both resection of a benign tumor and taking a biopsy of a malignant tumor from the pharynx and larynx. But, we could hardly remove vocal fold polyps because of the structural limitation of the scope. We demonstrated that the new video laryngo-pharyngoscope can be used safely and successfully in the inspection and removal of lesions in the oropharynx and supraglottic area of the larynx and will be a useful tool for minimally invasive office-based surgery. Auris, Nasus, Larynx 1879-1476 36 6 677 681 20091200 10.1016/j.anl.2009.04.006 19631482 read0013690/published_papers/15122717 Takao Imai Noriaki Takeda Mahito Ito Kazunori Sekine Gou Satou Yoshihiro Midoh Koji Nakamae Takeshi Kubo 3D analysis of benign positional nystagmus due to cupulolithiasis in posterior semicircular canal The characteristic of both the vertical-torsional positional nystagmus with long time constant and its disappearance at the neutral head position could diagnose cupulolithiasis in posterior semicircular canal (PSCC) in the eight patients with the PSCC type of benign paroxysmal positional vertigo (P-BPPV). The aim of the study was to diagnose cupulolithiasis in patients with P-BPPV. We used three-dimensional rotation axis analysis of nystagmus of the vertical-torsional positional nystagmus in 111 patients with P-BPPV and evaluated its time constant. We then examined whether the vertical-torsional positional nystagmus with long time constant disappeared at the neutral head position where the axis of the heavy cupula of the affected PSCC is aligned with gravity. The first parameter showed a wide variation that could be divided into two groups: one lasting more than 40 s in 8 patients and another below 20 s in 103 patients. Since the time constant of the positional nystagmus induced by cupulolithiasis was much longer than that induced by canalolithiasis, this finding suggests that cupulolithiasis in the PSCC induced the vertical-torsional positional nystagmus with a long time constant in the group of eight patients. The vertical-torsional positional nystagmus disappeared in these patients at the neutral head position, where the axis of the cupula of affected PSCC aligned with gravity. Acta Oto-Laryngologica 1651-2251 129 10 1044 1049 20091000 10.1080/00016480802566303 19058052 read0013690/published_papers/15122716 Masafumi Sakagami Minoru Ikeda Hiroshi Tomita Akihiro Ikui Tsunemasa Aiba Noriaki Takeda Akira Inokuchi Yuichi Kurono Mitsuyoshi Nakashima Yuji Shibasaki Osamu Yotsuya A zinc-containing compound, Polaprezinc, is effective for patients with taste disorders: randomized, double-blind, placebo-controlled, multi-center study. Conclusions. The effect of a zinc-containing compound, Polaprezinc, was shown to clinically improve the disease conditions of idiopathic taste disorders with no serious side effects in a well controlled double-blinded clinical study. Objectives. The purpose of the present study was to evaluate the efficacy and safety of a zinc-containing compound in the treatment of patients with idiopathic taste disorders, including patients with low serum zinc, by a Good Clinical Practice (GCP)-compliant, randomized, placebo-controlled, double-blind, multi-center clinical study. Subjects and methods. A group of 109 patients suffering from taste disorders was assigned into placebo and three treatment groups. Each group of patients was given either placebo (n=28), or 17 mg (n=27), 34 mg (n=26) or 68 mg (n=28) of oral zinc, Polaprezinc preparations, daily for 12 weeks. Results. The group of patients given 68 mg zinc showed a significant improvement in their gustatory sensitivity compared with the placebo group. The most common side effects observed were increase in serum triglyceride and serum alkaline phosphatase, decrease in serum iron, and some gastrointestinal incidents, although they were not serious. Acta Oto-Laryngologica 1651-2251 129 10 1115 1120 20091000 10.1080/00016480802552550 19037756 read0013690/published_papers/15122719 坂崎 弘幸 佐藤 公美 三根生 茜 瀧元 美和 合田 侑以 森実 加奈 長嶋 比奈美 Jiro Udaka 宇高 二良 Noriaki Takeda 武田 憲昭 1歳6ヵ月児および3歳児健康診査における聴覚スクリーニングの現状と問題点の検討 Audiology Japan 0303-8106 52 4 188 194 20090831 10.4295/audiology.52.188 read0013690/published_papers/15122720 Masum Shahriar Hiroyuki Mizuguchi Kazutaka Maeyama Yoshiaki Kitamura Naoki Orimoto Shuhei Horio Hayato Umehara Masashi Hattori Noriaki Takeda Hiroyuki Fukui Suplatast tosilate inhibits histamine signaling by direct and indirect down-regulation of histamine H1 receptor gene expression through suppression of histidine decarboxylase and IL-4 gene transcriptions Journal of Immunology 0022-1767 183 3 2133 2141 20090801 10.4049/jimmunol.0901058 19596986 2-s2.0-68149163186 read0013690/published_papers/15122729 Chisa Fujimoto Hiroshi Kido Takako Sawabuchi Dai Mizuno Masaki Hayama Hiroaki Yanagawa Noriaki Takeda Evaluation of nasal IgA secretion in normal subjects by nasal spray and aspiration. OBJECTIVE: Nasal washing (NW) is a popular method for collecting human nasal lavage fluid. However, for NW the subject must be trained, and the method is unsuitable for field studies on untrained subjects. To overcome this problem, we have developed an easy and painless method, a nasal spray and aspiration (NSA) method. METHODS: This method is different from NW in that the nasal cavity is misted over with saline, and the nasal lavage fluid is aspirated from the nostrils through a silicon tube. First, nasal lavage fluid was obtained twice by NSA with an interval of a week between lavages to evaluate intraindividual variability, and the IgA and protein levels in the nasal lavage fluid were measured by enzyme-linked immunosorbent assay and bicinchoninic acid assay, respectively. Next, the IgA value determined by NSA was compared with that by NW in another 12 normal subjects 2 days after NSA. RESULTS: In 10 normal subjects, mean volume of saline sprayed into the nose was 0.46+/-0.15 ml (mean+/-S.D.). Mean volume of aspirated nasal lavage fluid containing both sprayed saline and nasal secretion was 0.44+/-0.37 ml. The mean IgA level/mg protein in the nasal lavage fluid determined by NSA was 112+/-18 microg/mg protein at the first and 99+/-20 at the second times of measurement, being highly reproducible. The mean value by NSA was 114+/-19 microg/mg protein, being almost the same as that by NW of 99+/-27. CONCLUSION: These findings suggest that the IgA level/mg protein in nasal lavage fluid determined by NSA instead of NW might be useful for assessing the variability of nasal IgA secretion. Auris, nasus, larynx 1879-1476 36 3 300 4 20090600 10.1016/j.anl.2008.09.005 19013037 read0013690/published_papers/15122722 Akemi Sugita-Kitajima 北島 明美 Kazunori Sekine 関根 和教 Takao Imai 今井 貴夫 Noriaki Takeda 武田 憲昭 Izumi Koizuka 肥塚 泉 Eye analysis of ocular counter rolling: Is there an effect of somatosensory? 体性感覚がOcular counter rollingに及ぼす影響の検討 Equilibrium Research 0385-5716 68 3 138 142 20090600 10.3757/jser.68.138 2-s2.0-68549133336 read0013690/published_papers/15122726 Naoki Toda 戸田 直紀 Hidetaka Iwasaki 岩? 英隆 東 貴弘 Seizo Oyama 大山 晴三 高橋 美香 Katsuhiko Nakamura 中村 克彦 Noriaki Takeda 武田 憲昭 第8脳神経症状のみを呈する耳性帯状疱疹(Haymann IV型)の検討 Facial Nerve Research Japan 0914-790X 28 166 169 20090228 read0013690/published_papers/15122725 Katsuhiko Nakamura 中村 克彦 Seizo Oyama 大山 晴三 Hidetaka Iwasaki 岩? 英隆 高橋 美香 Naoki Toda 戸田 直紀 東 貴弘 Noriaki Takeda 武田 憲昭 神経障害の程度に応じたミラーバイオフィードバック Facial Nerve Research Japan 0914-790X 28 0 129 131 20090228 read0013690/published_papers/15122724 Seizo Oyama 大山 晴三 Katsuhiko Nakamura 中村 克彦 Naoki Toda 戸田 直紀 Hidetaka Iwasaki 岩? 英隆 東 貴弘 高橋 美香 Noriaki Takeda 武田 憲昭 病的共同運動に対するボツリヌス治療とミラーバイオフィードバックの併用療法の治療効果 Facial Nerve Research Japan 0914-790X 28 0 126 128 20090228 read0013690/published_papers/15122723 Hidetaka Iwasaki 岩? 英隆 Naoki Toda 戸田 直紀 東 貴弘 Seizo Oyama 大山 晴三 高橋 美香 Katsuhiko Nakamura 中村 克彦 Noriaki Takeda 武田 憲昭 病的共同運動に対するボツリヌス治療とミラーバイオフィードバック併用療法におけるQOLの評価 Facial Nerve Research Japan 0914-790X 28 0 132 134 20090228 read0013690/published_papers/15122727 Hideo Shojaku Yukio Watanabe Toshiaki Yagi Masahiro Takahashi Taizo Takeda Tetsuo Ikezono Juichi Ito Takeshi Kubo Mamoru Suzuki Masaya Takumida Noriaki Takeda Nobuhiko Furuya Hiroshi Yamashita Changes in the characteristics of definite Meniere's disease over time in Japan: a long-term survey by the Peripheral Vestibular Disorder Research Committee of Japan, formerly the Meniere's Disease Research Committee of Japan. CONCLUSION: The incidence of new cases of Meniere's disease (MD) in elderly patients aged 60 years or more was found to have increased over time after correction for age distribution in the overall population. Job- and care-related fatigue may be involved in the recent increase in elderly-onset cases because physical and mental fatigue can induce onset of the disease. OBJECTIVES: Changes over time in the epidemiologic characteristics of MD in Japan were analyzed. MATERIALS AND METHODS: Between 1975 and 2006, four nationwide, multi-center surveys of MD were conducted by the Meniere's Disease Research Committee of Japan (1975-1976) and the Peripheral Vestibular Disorders Research Committee of Japan (1982-1984, 1990, and 2001-2006). Information was collected by the committee members on a total of 1368 de novo cases of definite MD, 520 reported in the first survey, 290 in the second survey, 148 in the third survey, and 410 in the fourth survey. RESULTS: Clear changes were seen over time in the population-adjusted sex distribution of the disease and population-adjusted age at onset. The number of definite MD cases in females increased over time relative to the number of cases in males. The proportion of cases in which onset occurred at 60 years of age or more increased over time when the number of cases in each age group was adjusted for changes in age distribution of the population over time. From the time of the third survey, there was a slight increase in the proportion of cases with bilateral involvement. Acta oto-laryngologica 1651-2251 129 2 155 60 20090200 10.1080/00016480802112587 18607900 read0013690/published_papers/15122728 Gou Satou Atsuhiko Uno Arata Horii Hayato Umehara Yoshiaki Kitamura Kazunori Sekine Koichi Tamura Hiroyuki Fukui Noriaki Takeda Effects of hypergravity on histamine H1 receptor mRNA expression in hypothalamus and brainstem of rats: implications for development of motion sickness The study findings suggest that histamine was released from the axon terminals in the hypothalamus and brainstem and the released histamine activated post-synaptic H1 receptors there, resulting in the development of motion sickness. We first examined which subtype of post-synaptic histaminergic receptor was responsible for the development of motion sickness. We then examined whether H1 receptors were up-regulated in various areas of the rat brain after 2 G hypergravity load, because the stimulation of H1 receptor was reported to up-regulate the level of H1 receptor protein expression through augmentation of H1 receptor mRNA expression. For this purpose, we used an animal model of motion sickness, using pica (eating non-nutritive substances such as kaolin), as a behavioral index in rats. After 2 G hypergravity load, rats ate a significant amount of kaolin, indicating that they suffered from motion sickness. The hypergravity-induced kaolin intake was suppressed by mepyramine, but not by terfinadine or zolantizine. This finding indicates that cerebral post-synaptic H1 but not H2 or peripheral H1 receptors play an important role in the development of motion sickness. The expression of H1 receptor mRNA was up-regulated in the hypothalamus and brainstem, but not in the cerebral cortex after 2 G hypergravity load in rats. Acta Oto-Laryngologica 1651-2251 129 1 45 51 20090100 10.1080/00016480802008173 18607976 read0013690/published_papers/15122721 Takuma Sekita 関田 拓馬 Akio Kondou 近藤 昭男 Noriaki Takeda 武田 憲昭 Endoscopic re-operation on a patient with sphenoidal sinus cyst through contralateral sphenoidal sinus under X-ray imaging 術中X線透視を用い対側よりアプローチした蝶形骨洞嚢胞再手術例 Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 102 7 559 563 20090000 10.5631/jibirin.102.559 2-s2.0-68049137336 read0013690/published_papers/15122718 Hitomi Kawata 川田 仁美 Go Sato 佐藤 豪 Koji Abe 阿部 晃治 Noriaki Takeda 武田 憲昭 A case of solitary plasmacytoma of bone in the clivus 頭蓋底骨斜台部に発生した骨の孤発性形質細胞腫例 Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 102 9 773 779 20090000 10.5631/jibirin.102.773 2-s2.0-70350164879 read0013690/published_papers/15122714 Asish Kumar Das Hiroyuki Mizuguchi Madoka Kodama Shrabanti Dev Hayato Umehara Yoshiaki Kitamura Chiyo Matsushita Noriaki Takeda Hiroyuki Fukui Sho-seiryu-to suppresses histamine signaling at the transcriptional level in TDI-sensitized nasal allergy model rats Japanese Society of Allergology Allergology International 1440-1592 58 1 81 88 20090000 10.2332/allergolint.O-07-526 19050374 2-s2.0-65449137864 read0013690/published_papers/15122730 Hiroyuki Mizuguchi Masaya Hatano Chiyo Matsushita Hayato Umehara Wakana Kuroda Yoshiyuki Kitamura Noriaki Takeda Hiroyuki Fukui Repeated Pre-treatment With Antihistamines Causes Transcriptional Up-regulations of Histamine H-1 Receptor and Interleukin-4 Genes in Toluene-2,4-diisocyanate-Sensitized Rats JOURNAL OF PHARMACOLOGICAL SCIENCES 1347-8613 108 4 480 486 20081200 10.1254/jphs.08222FP 19075512 read0013690/published_papers/15122733 中野 誠一 山本 元久 嶽村 貞治 Naozumi Ishimaru 石丸 直澄 Katsushi Miyazaki 宮崎 かつし Koichi Tamura 田村 公一 氷見 徹夫 Yoshio Hayashi 林 良夫 Noriaki Takeda 武田 憲昭 Three Cases of Mikulicz's Disease as an IgG4-related Disease ミクリッツ病3例の検討 We reported three cases of Mikuhcz&#039;s disease. Mikulicz&#039;s disease was diagnosed by the following criteria: 1) symmetrical enlargement of the lacrimal and salivary glands lasting at least 3 months&#039;, 2) the lacrimal and salivary glands were microscopically involved in the infiltration of inflammatory cells, 3) sarcoidosis and other lymphoproliferative diseases were excluded. Three patients with Mikulicz&#039;s disease were all characterized by elevated IgG4 concentration in the serum and prominent infiltration of IgG4-positive plasmacytes in the minor salivary glands. On the contrary, there were no findings indicating sicca syndrome or anti-SS-A and SS-B antibodies, which characterize Sj?gren syndrome. It is suggested that Mikulicz&#039;s disease is an IgG4-related plasmacytec disease, with a pathogenesis differing from that of Sj?gren syndrome. The Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 101 8 591 597 20080801 10.5631/jibirin.101.591 read0013690/published_papers/15122732 Gou Satou 佐藤 豪 今井 貴夫 Kazunori Sekine 関根 和教 Yoshiaki Kitamura 北村 嘉章 Noriaki Takeda 武田 憲昭 頸性めまいを訴えたBow hunter's stroke例 We report a case of Bow hunters stroke with the complaint of cervical vertigo. A 48-year-old man complained of cervical vertigo following head rotation to the left. He showed positional nystagmus when his head was rotated to the left in the supine position and, if the head rotation was maintained, he felt a gradual drop into unconsciousness. The positional nystagmus and fainting were not, however, induced in the patient in the left lateral decubitus position without head rotation. Three-dimensional analysis of his positional nystagmus showed its inconsistent rotational axis, which is different from the single rotational axis in patients with peripheral positional nystagmus. These findings suggested the central cervical positional vertigo/nystagmus in the patients. MRI showed an old infarction of the left cerebellum and MRA showed severe hypoplasia of the left vertebral artery. Vertebral angiography showed severe stenosis of the left vertebral artery and the mechanical occlusion of the right vertebral artery by the atlas-axis joint at C1-C2 when the patients head was rotated to the left. Therefore, it is demonstrated that his positional vertigo/nystagmus with fainting caused by head rotation to the left was induced by the vertebrobasilar insufficiency due to mechanical occlusion of the vertebral artery associated with head rotation, resulting in the diagnosis of Bow hunters stroke in this patient. Japan Society for Equilibrium Research Equilibrium Research 0385-5716 67 4 301 306 20080801 10.3757/jser.67.301 read0013690/published_papers/15122734 佐藤 孝宣 Koji Abe 阿部 晃治 Shin-ichi Nakagawa 中川 伸一 Noriaki Takeda 武田 憲昭 近藤 英司 Katsushi Miyazaki 宮崎 かつし 外傷による眼窩先端症候群の1例 Otologia Fukuoka 耳鼻と臨床 2185-1034 54 4 200 205 20080700 10.11334/jibi1954.54.4_200 read0013690/published_papers/15122736 Yoshiaki Kitamura 北村 嘉章 黒田 若奈 K DasAsish Hiroyuki Fukui 福井 裕行 Noriaki Takeda 武田 憲昭 鼻過敏症モデルおけるヒスタミンH1受容体発現上昇機構とその制御について 頭頚部自律神経 22 24 26 20080600 read0013690/published_papers/15122735 関田 拓馬 近藤 昭男 Noriaki Takeda 武田 憲昭 Two Cases of Incomplete Type and Suspected Type of Behcet's Disease ベーチェット病不全型例と疑い例 We report two cases of an incomplete type and a suspected type of Beh?et&#039;s disease that met the diagnostic criteria. Both patients complained of acute sore throat with multiple oropharyngeal aphthous ulcers. The first case had additional diagnostic symptoms of genital ulcers, skin lesions of erythema nodosum with gastrointestinal ulcers, leading to a diagnosis of incomplete type of Beh?et&#039;s disease. The second patient had additional diagnostic symptoms of genital ulcers with positive HLA-B51 and abnomal signals on brain MRI, leading to a diagnosis of suspected type of Beh?et&#039;s disease. The Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 101 6 465 471 20080601 10.5631/jibirin.101.465 read0013690/published_papers/15122737 藤井 達也 Naoki Toda 戸田 直紀 Noriaki Takeda 武田 憲昭 Two Cases of Neurofibromatosis Type 2 神経線維腫症2型の2例 We reported two cases of neurofibromatosis type 2. Case 1 was a 24-year-old woman with bilateral slight to moderate sensorineural hearing loss. MRI demonstrated a large acoustic tumor (AT) measuring 4.0cm on the right side and another small AT of 1.0cm on the left side. Surgical resection of the right AT resulted in deafness of the right ear. She decided to delay surgery on the left ear until the hearing diminished and/or the tumor grew. However, the remaining hearing of the left ear became further gradually impaired reaching deafness 5 years later without apparent growth of the left AT. Case 2 was a 36-year-old man with moderate sensorineural hearing loss of the left ear and juvenile deafness of the rightear. He showed right peripheral facial palsy and cerebellar ataxia. MRI demonstrated bilateral ATs measuring 2.0cm and 2.5cm, respectively, in addition to several meningiomas in the brain and neurofibromas in the spine. Neurosurgeons estimated that there was no indication for surgical resection or gammaknife treatment. The Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 101 5 343 347 20080501 10.5631/jibirin.101.343 read0013690/published_papers/15122740 Koji Abe 阿部 晃治 押川 千恵 Koichi Tamura 田村 公一 Noriaki Takeda 武田 憲昭 False-positive FDG-PET Finding in the Contralateral Larynx of Patients with Unilateral Laryngeal Palsy FDG-PETにて健側喉頭に偽陽性を示した一側喉頭麻痺症例 Positron emission tomography with 18F-fluorodeoxyglucose (FDG-PET) is useful for the diagnosis of head and neck cancers. We report 5 cases of abnormal FDG uptake in the contralateral larynx of patients with unilateral laryngeal palsy due to lung cancer, lung metastasis of breast cancer, lung metastasis of mesopharyngeal cancer, idiopathic cause and laryngeal cancer after complete remission. We concluded that overactivity of the laryngeal muscles that compensated for the paralyzed vocal cord caused a false-positive PET finding with abnormal uptake of FDG in the contralateral larynx of patients with unilateral laryngeal palsy. The Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 101 4 299 302 20080401 10.5631/jibirin.101.299 read0013690/published_papers/15122739 島田 亜紀 Kazunori Sekine 関根 和教 Gou Satou 佐藤 豪 Noriaki Takeda 武田 憲昭 回転性めまいで発症した若年性Wallenberg syndromeの2症例 We report two young patients of Wallenberg syndrome who presented with acute vertigo as the initial symptom. Neither Case 1, an 8-year-old girl, nor Case 2, a 29-year-old man, showed any abnormal findings on the initial magnetic resonance imaging (MRI) on day 1. In addition to nystagmus, several neurological signs became positive during the clinical course. Finally, the diagnosis of Wallenberg syndrome was made in both cases based on the detection of a lateral medullary infarction in a follow-up MRI conducted on day 4. Stroke should be considered in the differential diagnosis of acute vertigo, even in young patients without risk factors for cerebrovascular disorders, such as hypertension, diabetes and/or hyperlipidemia. Since MRI may show no abnormalities in the very early stages of stroke, neurological examinations are useful to establish the diagnosis in cases presenting with vertigo induced by brain stem or cerebellar infarction. Japan Society for Equilibrium Research Equilibrium Research 0385-5716 67 2 115 120 20080401 10.3757/jser.67.115 read0013690/published_papers/15122741 Hironori Akizuki 秋月 裕則 近藤 英司 Seizo Oyama 大山 晴三 Koji Abe 阿部 晃治 Koichi Tamura 田村 公一 Noriaki Takeda 武田 憲昭 Preoperative MRI for Surgery on Multiple Paranasal Mucoceles 多胞性副鼻腔嚢胞の術前MRIの有用性 We reported two cases of multiple paranasal mucoceles, in which MRI was useful to choose the appropriate surgical approach. The first case was a 53-year-old woman, with right visual disturbance due to spheno-ethmoid mucoceles. CT showed a large mucocele in the right spheno-ethmoid sinus, which was closely associated with the right optic nerve. However, MRI could detect a small mucocele lateral to the large one and showed that the small one, but not the large one, involved the optic nerve. The surgical treatment with an endonasal endoscopic approach and navigation-assisted endoscopic drainage of both mucoceles was performed, resulting in complete recovery of visual acuity.The second case was a 52-year-old woman with three paranasal mucoceles. CT showed two mucoceles in the right maxillary sinus. However, MRI showed that the lateral lesion was separated from the medial wall of the nasal cavity by two other medial lesions in the maxillary sinus. Surgical treatment was performed by an external approach and drainage of the three mucoceles was successful. The Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 101 3 195 200 20080301 10.5631/jibirin.101.195 read0013690/published_papers/15122744 Seizo Oyama 大山 晴三 Katsuhiko Nakamura 中村 克彦 Naoki Toda 戸田 直紀 Hidetaka Iwasaki 岩? 英隆 東 貴弘 高橋 美香 Noriaki Takeda 武田 憲昭 ボツリヌス治療とミラーバイオフィードバックの併用による病的共同運動の治療効果 Facial Nerve Research Japan 0914-790X 27 0 189 191 20080130 read0013690/published_papers/15122743 Katsuhiko Nakamura 中村 克彦 Seizo Oyama 大山 晴三 Hidetaka Iwasaki 岩? 英隆 高橋 美香 Naoki Toda 戸田 直紀 東 貴弘 Noriaki Takeda 武田 憲昭 完全脱神経をきたした顔面神経麻痺例に対するリハビリテーション Facial Nerve Research Japan 0914-790X 27 0 186 188 20080130 read0013690/published_papers/15122932 Noriaki Takeda 武田 憲昭 メニエール病 今日の耳鼻咽喉科頭頸部外科治療指針 174 175 20080000 read0013690/published_papers/15122745 Takao Imai Noriaki Takeda Go Sato Kazunori Sekine Mahito Ito Koji Nakamae Takeshi Kubo Changes in slow phase eye velocity and time constant of positional nystagmus at transform from cupulolithiasis to canalolithiasis ACTA OTO-LARYNGOLOGICA 0001-6489 128 1 22 28 20080000 10.1080/00016480701283752 17851914 read0013690/published_papers/15122742 Takao Imai Noriaki Takeda Go Sato Kazunori Sekine Mahito Ito Koji Nakamae Takeshi Kubo Differential diagnosis of true and pseudo-bilateral benign positional nystagmus ACTA OTO-LARYNGOLOGICA 0001-6489 128 2 151 158 20080000 10.1080/00016480701477594 17851906 read0013690/published_papers/15122738 Haruhiko Shizuku Yohji Hori Tetsuya Uemura Hideyuki Nakagawa Kazunori Matsuda Bukasa Kalubi Noriaki Takeda Combination of Bernouilli effect producing maneuver-induced pharyngeal narrowing rate with body mass index as predictive tool for obstructive sleep apnea syndrome ACTA OTO-LARYNGOLOGICA 0001-6489 128 5 569 573 20080000 10.1080/00016480701558922 18421613 read0013690/published_papers/15122731 Seizo Ohyama Suetaka Nishiike Hiroshi Watanabe Katsunori Matsuoka Noriaki Takeda Effects of optokinetic stimulation induced by virtual reality on locomotion: a preliminary study ACTA OTO-LARYNGOLOGICA 0001-6489 128 11 1211 1214 20080000 10.1080/00016480801901683 19241605 read0013690/published_papers/15122748 Seizo Ohyama Suetaka Nishiike Hiroshi Watanabe Katsunori Matsuoka Hironori Akizuki Noriaki Takeda Tamotsu Harada Autonomic responses during motion sickness induced by virtual reality AURIS NASUS LARYNX 0385-8146 34 3 303 306 20070900 10.1016/j.anl.2007.01.002 17336009 read0013690/published_papers/15122749 Masaki Hayama Yuushi Okumura Etsuhisa Takahashi Aki Shimabukuro Manabu Tamura Noriaki Takeda Takeshi Kubo Hiroshi Kido Identification and analysis of the promoter region of the type II transmembrane serine protease polyserase-1 and its transcript variants BIOLOGICAL CHEMISTRY 1431-6730 388 8 853 858 20070800 10.1515/BC.2007.093 17655505 read0013690/published_papers/15122752 Asish K. Das Sachiho Yoshimura Ryoko Mishima Katsumi Fujimoto Hiroyuki Mizuguchi Shrabanti Dev Yousuke Wakayama Yoshiaki Kitamura Shuhei Horio Noriaki Takeda Hiroyuki Fukui Stimulation of histamine H-1 receptor up-regulates histamine H-1 receptor itself through activation of receptor gene transcription JOURNAL OF PHARMACOLOGICAL SCIENCES 1347-8613 103 4 374 382 20070400 10.1254/jphs.FP0061411 17409634 read0013690/published_papers/15122757 Gou Satou 佐藤 豪 Kazunori Sekine 関根 和教 Masahiro Ando 安藤 正裕 Osamu Jinnouchi 陣内 自治 Naoki Toda 戸田 直紀 Koji Abe 阿部 晃治 Koichi Tamura 田村 公一 Noriaki Takeda 武田 憲昭 当科における真珠腫性中耳炎の術式と術後聴力成績 Otologia Fukuoka 耳鼻と臨床 2185-1034 53 1 22 26 20070000 10.11334/jibi1954.53.1_22 read0013690/published_papers/15122756 Noriaki Takeda 武田 憲昭 Kazunori Sekine 関根 和教 Gou Satou 佐藤 豪 前庭型メニエール病の臨床的検討 厚生労働省科学研究費補助金 特定疾患対策研究事業 前庭機能異常に関する調査研究 平成18年度報告書 134 137 20070000 read0013690/published_papers/15122755 Noriaki Takeda 武田 憲昭 Gou Satou 佐藤 豪 Kazunori Sekine 関根 和教 今井 貴夫 眼振の3次元主軸解析による両側性後半規管BPPVの病態解明 厚生労働省科学研究費補助金 特定疾患対策研究事業 前庭機能異常に関する調査研究 平成18年度報告書 161 166 20070000 read0013690/published_papers/15122754 渡辺 行雄 池田 哲郎 伊藤 寿一 伊藤 八次 久保 武 鈴木 衛 高橋 正紘 工田 昌也 竹田 泰三 Noriaki Takeda 武田 憲昭 古屋 信彦 山下 裕司 平成18年度内リンパ水腫疾患疫学臨床調査 厚生労働省科学研究費補助金 特定疾患対策研究事業 前庭機能異常に関する調査研究 平成18年度報告書 130 133 20070000 read0013690/published_papers/15122753 高橋 正紘 池田 哲郎 伊藤 寿一 伊藤 八次 久保 武 鈴木 衛 竹田 泰三 Noriaki Takeda 武田 憲昭 工田 昌也 長沼 英明 山下 裕司 渡辺 行雄 保坂 隆 他施設におけるメニエール病行動特性調査 厚生労働省科学研究費補助金 特定疾患対策研究事業 前庭機能異常に関する調査研究 平成18年度報告書 107 117 20070000 read0013690/published_papers/15122751 Eiji Kondo 近藤 英司 Yoshiaki Kitamura 北村 嘉章 Osamu Jinnouchi 陣内 自治 Shinichi Nakagawa 秋月 裕則 Noriaki Takeda 由良 いづみ Hironori Akizuki 中川 英幸 Izumi Yura 中川 伸一 Hideyuki Nakagawa 佐野 暢哉 Nobuya Sano 武田 憲昭 Two cases of invasive aspergillus sinusitis and mastoiditis successfully treated with voriconazole ボリコナゾールが著効した副鼻腔と中耳の侵襲性アスペルギルス症例 Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 100 6 473 483 20070000 10.5631/jibirin.100.473 2-s2.0-34250832775 read0013690/published_papers/15122750 Chisa Fujimoto 藤本 知佐 Akio Kondo 近藤 昭男 Masahiro Morita 守田 雅弘 Noriaki Takeda 武田 憲昭 Follow-up survey of patulous eustachian tube syndrome 耳管開放症例の追跡調査 Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 100 8 637 641 20070000 10.5631/jibirin.100.637 2-s2.0-34547955358 read0013690/published_papers/15122747 Takahiro Azuma 東 貴弘 Naoki Toda 戸田 直紀 Koichi Tamura 田村 公一 Noriaki Takeda 武田 憲昭 Evaluation of tonsillectomy with four different methods 4種類の機器による扁摘の比較検討 Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 100 9 743 746 20070000 10.5631/jibirin.100.743 2-s2.0-34548864366 read0013690/published_papers/15122746 Sei-Ichi Nakano 中野 誠一 Hitomi Kawata 川田 仁美 Takanori Sato 佐藤 孝宣 Shin-Ichi Nakagawa 宮崎 かつし Noriaki Takeda 中川 伸一 Katsushi Miyazaki 武田 憲昭 A case report of extrapharyngeal foreign body CTが有用であった咽頭腔外魚骨異物例 Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 100 12 1009 1013 20070000 10.5631/jibirin.100.1009 2-s2.0-37349111489 read0013690/published_papers/15122758 Naoki Toda 戸田 直紀 中川 英幸 東 貴弘 Seizo Oyama 大山 晴三 Noriaki Takeda 武田 憲昭 二次性真珠腫の3症例 Secondary cholesteatoma, an acquired open-typed cholesteatoma, is considered to be formed by disorderly migration of epidermis. The epidermis, which is activated by chronic inflammation, becomes to extend from the manubrium of the malleus at the center of a perforation of the tympanic membrane. The epidermis then passes along the inner surface of the tympanic membrane through the edge of perforation of an opentyped cholesteatoma. We reported 3 cases of secondary cholesteatoma. Patients 1 and 2 showed common characteristics of secondary cholesteatoma that have been reported: a large perforation of the tympanic membrane, long-term inflammation of the middle ear and an open-typed cholesteatoma extended from the manubrium of the malleus to the inner surface of the tympanic membrane. However, in patients 3 with a traumatic small perforation of the tympanic membrane, his secondary cholesteatoma seemed to be formed under a specific condition of severe persistent inflammation due to MRSA. After tympanoplasty, it is suggested that the epidermis folded on the inner surface of the tympanic membrane at the edged of the perforation was activated by MRSA inflammation and extended to form an open-typed cholesteatoma. THE JAPAN OTOLOGICAL SOCIETY Otology Japan 0917-2025 16 5 606 610 20061225 10.11289/otoljpn1991.16.5_606 read0013690/published_papers/15122764 Yohji Hori Haruhiko Shizuku Akio Kondo Hideyuki Nakagawa Bukasa Kalubi Noriaki Takeda Endoscopic evaluation of dynamic narrowing of the pharynx by the Bernouilli effect producing maneuver in patients with obstructive sleep apnea syndrome AURIS NASUS LARYNX 0385-8146 33 4 429 432 20061200 10.1016/j.anl.2006.05.012 16904855 read0013690/published_papers/15122759 合田 正和 Kazunori Sekine 関根 和教 Katsuhiko Nakamura 中村 克彦 Noriaki Takeda 武田 憲昭 A Case of Dissociated Taste Impairment after Injury of the Major Petrosus Nerve 頭部外傷後の大錐体神経障害による乖離性味覚障害例 We report the case of a 16-year-old female patient with taste impairment of the soft palate. After receiving a skull fracture due to a traffic accident, she experienced the taste of bitter chocolate. CT showed the fracture around the right temporal bone. Electrogustometry showed that the decreased sensation of taste was restricted to the right soft palate. Shirmer test showed that lacrimal secretion of the right eye was decreased. These findings indicated that the selective injury of the major petrosus nerve on the right side due to the fracture caused taste impairment of the soft palate. It has been reported that the sensation of a sweet taste is more sensitive in the soft palate of young women. Therefore, it is suggested that the taste impairment of the soft palate caused the dissociated impairment of a sweet taste, resulting in the taste of bitter chocolate in the present case. The Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 99 11 901 903 20061101 10.5631/jibirin.99.901 read0013690/published_papers/15122761 Kazunori Sekine Takao Imai Go Sato Mahito Ito Noriaki Takeda Natural history of benign paroxysmal positional vertigo and efficacy of Epley and Lempert maneuvers OTOLARYNGOLOGY-HEAD AND NECK SURGERY 0194-5998 135 4 529 533 20061000 10.1016/j.otohns.2005.09.021 17011412 read0013690/published_papers/15122773 Chizuru Ueda Tsukasa Takaoka Nobuko Sarukura Kazunori Matsuda Yoshiaki Kitamura Naoki Toda Takeshi Tanaka Shigeru Yamamoto Noriaki Takeda Zinc nutrition in healthy subjects and patients with taste impairment from the view point of zinc ingestion, serum zinc concentration and angiotensin converting enzyme activity AURIS NASUS LARYNX 0385-8146 33 3 283 288 20060900 10.1016/j.anl.2006.01.006 16530365 read0013690/published_papers/15122765 高橋 美香 Jiro Udaka 宇高 二良 Noriaki Takeda 武田 憲昭 剣道によると思われた難聴の臨床的検討と発症機序に関する考察 We report 6 cases of Japanese fencing players with sensorineural hearing loss associated in fencing, Kendo. Kendo-associated hearing loss is characterized by notch at 2000Hz, at 4000Hz and both. The hearing loss at 2000Hz initially was reversible, and then became permanent. On the contrary, the hearing loss at 4000Hz is induced by repeated exposure to loud noise(about 120dB)at beating a kendo mask by a bamboo sword. It is also suggested that the hearing loss at 2000Hz is induced by concussion of the inner ear with vibration of the head at a peak frequency of 2000Hz when a bamboo sword beats a kendo mask. Independent appearance and progression of 4000Hz and 2000Hz notches manifest the variety of hearing loss patterns associated with Kendo. THE JAPAN OTOLOGICAL SOCIETY Otology Japan 0917-2025 16 3 178 182 20060725 10.11289/otoljpn1991.16.178 read0013690/published_papers/15122767 Noriaki Takeda 武田 憲昭 危険なめまい 南山堂 The Journal of Therapy 治療 0022-5207 88 5 1473 1477 20060500 read0013690/published_papers/15122770 T Imai N Takeda M Ito K Nakamae H Sakae H Fujioka T Kubo Three-dimensional analysis of benign paroxysmal positional nystagmus in a patient with anterior semicircular canal variant OTOLOGY & NEUROTOLOGY 1531-7129 27 3 362 366 20060400 10.1097/00129492-200604000-00012 16639275 read0013690/published_papers/15122769 Noriaki Takeda Autonomic Dysfunction in Patients with Vertigo JMAJ: Japan Medical Association Journal 1346-8650 49 4 153 157 20060400 read0013690/published_papers/15122768 北原 糺 Noriaki Takeda 武田 憲昭 肥塚 泉 荻野 仁 前庭型メニエール病に対するプロスタグランディンI2誘導体の治療効果 We treated 44 cases of vestibular M?ni?res disease with prostaglandin I&lt;SUB&gt;2&lt;/SUB&gt; (PGI&lt;SUB&gt;2&lt;/SUB&gt;), a vasodialator, at a dose of 120μg per day for more than two months (mean: 8.0 months). The long-term administration of constant daily amounts of PGI&lt;SUB&gt;2&lt;/SUB&gt; attained good long-term results in vertigo according to the criteria of the Japan Society for Equilibrium Research. The results were as follows: the administration of PGI&lt;SUB&gt;2&lt;/SUB&gt; completely controlled vertigo in 65.9% (29/44) and improved it in 29.5% (13/44); however, four cases suffered from the typical type of Menieres disease thereafter (9.1%: 4/44). The objective findings of nystagmus were also reduced in 85.7% (24/28) after PGI2 treatments.&lt;BR&gt;PGI&lt;SUB&gt;2&lt;/SUB&gt; was significantly more effective in patients with a vertigo duration within 120 min and -SP/AP negative results on electro-cochleogram (ECoG) than the others. On the contrary, patients with a vertigo duration of more than 120 min and -SP/AP positive results on ECoG experienced cochlear symptoms together with vertiginous sensations later. These patients should be treated with an oral osmotic diuretic, isosorbide. These findings suggest that cases presently diagnosed as vestibular M?ni?res disease could include at least two kinds of oto-pathologies; vascular disease and endolymphatic hydrops. Equilibrium Research 0385-5716 65 2 116 121 20060401 10.3757/jser.65.116 read0013690/published_papers/15122771 Shin-ichi Nakagawa 中川 伸一 Koichi Tamura 田村 公一 Koji Abe 阿部 晃治 Noriaki Takeda 武田 憲昭 喉頭截開術の適応と術式について The Journal of Japan Society for Clinical Anesthesia 日本臨床麻酔学会誌 0285-4945 26 2 225 232 20060315 10.2199/jjsca.26.225 read0013690/published_papers/15122772 Naoki Toda 戸田 直紀 東 貴弘 Katsuhiko Nakamura 中村 克彦 Noriaki Takeda 武田 憲昭 Three cases of herpes zoster oticus with only the 8th cranial nerve dysfunction 第8脳神経症状のみを呈した耳性帯状疱疹の3症例 Facial Nerve Research Japan 0914-790X 26 90 93 20060310 read0013690/published_papers/15123033 Noriaki Takeda Autonomic Dysfunction in Patients with Vertigo JAAM 49 4 153 157 20060101 read0013690/published_papers/15122783 今井 貴夫 Noriaki Takeda 武田 憲昭 BPPVと耳石器機能 JOHNS 22 2 155 158 20060000 read0013690/published_papers/15122782 Noriaki Takeda 武田 憲昭 めまいといえば，メイロンでよいのか? 治療別冊 88 3 1098 1099 20060000 read0013690/published_papers/15122781 Noriaki Takeda 武田 憲昭 Tsukasa Takaoka 高岡 司 上田 千鶴 アンギオテンシン変換酵素活性比を用いた味覚障害患者の亜鉛栄養状態の評価 日本味と匂学会誌 13 1 29 34 20060000 10.18965/tasteandsmell.13.1_29 read0013690/published_papers/15122780 Noriaki Takeda 武田 憲昭 Rieger syndrome 耳鼻咽喉科・頭頸部外科 78 5 237 237 20060000 read0013690/published_papers/15122779 Noriaki Takeda 武田 憲昭 Reye syndrome 耳鼻咽喉科・頭頸部外科 78 5 236 236 20060000 read0013690/published_papers/15122778 Noriaki Takeda 武田 憲昭 Riley-Day syndrome(家族性自律神経失調症) 耳鼻咽喉科・頭頸部外科 78 5 238 238 20060000 read0013690/published_papers/15122777 Noriaki Takeda 武田 憲昭 めまいの薬物療法 綜合臨床 55 10 2519 2520 20060000 read0013690/published_papers/15122776 Noriaki Takeda 武田 憲昭 Kazunori Sekine 関根 和教 Gou Satou 佐藤 豪 Kazuhito Rokutan 六反 一仁 メニエール病患者におけるストレス関連遺伝子発現変化のDNAマイクロアレイ解析 厚生労働省科学研究補助金，特定疾患対策研究事業，前庭機能異常に関する調査研究，平成17年度報告書 148 152 20060000 read0013690/published_papers/15122775 Noriaki Takeda 武田 憲昭 肥塚 泉 荻野 仁 遅発性内リンパ水腫症例の臨床的検討 厚生労働省科学研究費補助金 特定疾患対策研究事業 前庭機能異常に関する調査研究 平成17年度報告書 153 155 20060000 read0013690/published_papers/15122774 Takao Imai Noriaki Takeda Mahito Ito Koji Nakamae Hideki Sakae Hiromu Fujioka Takashi Matsunaga Takeshi Kubo Benign paroxysmal positional vertigo due to a simultaneous involvement of both horizontal and posterior semicircular canals AUDIOLOGY AND NEURO-OTOLOGY 1420-3030 11 3 198 205 20060000 10.1159/000091892 16534183 read0013690/published_papers/15122766 Yoshiaki Kitamura Asish K. Das Yuki Murata Kazutaka Maeyama Shrabanti Dev Yousuke Wakayama Bukasa Kalubi Noriaki Takeda Hiroyuki Fukui Dexamethasone suppresses histamine synthesis by repressing both transcription and activity of HDC in allergic rats Japanese Society of Allergology Allergology International 1440-1592 55 3 279 286 20060000 10.2332/allergolint.55.279 17075268 2-s2.0-33748930011 read0013690/published_papers/15122763 Hideyuki Nakagawa 中川 英幸 Koichi Tamura 田村 公一 Koji Abe 阿部 晃治 Katsushi Miyazaki 宮崎 かつし Hironori Akizuki 秋月 裕則 Noriaki Takeda 武田 憲昭 First bite syndrome after dissection of parapharyngeal tumor First bite syndrome2症例と発症機序 Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 99 9 751 757 20060000 10.5631/jibirin.99.751 2-s2.0-33748934183 read0013690/published_papers/15122762 Kazunori Matsuda 松田 和徳 Yoshiaki Kitamura 北村 嘉章 Kazunori Sekine 関根 和教 Katsushi Miyazaki 宮崎 かつし Koichi Tamura 田村 公一 Noriaki Takeda 山本 由佳 Yuka Yamamoto 西山 佳宏 Yoshihiro Nishiyama 武田 憲昭 The usefulness of FDG-PET in diagnosing head and neck cancer - Report of four cases 頭頸部癌の診断にFDG-PETが有用であった4例 Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 99 9 771 780 20060000 10.5631/jibirin.99.771 2-s2.0-33748922925 read0013690/published_papers/15122760 Eiji Kondo 近藤 英司 Koichi Tamura 田村 公一 Hironori Akizuki 中川 英幸 Katsushi Miyazaki 秋月 裕則 Noriaki Takeda 宮崎 かつし Hideyuki Nakagawa 武田 憲昭 A case of tracheobronchial foreign body diagnosed by multi-detector row CT Multi-detector Row CT(多列検出器型CT)が診断に有用であった気道異物例 Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 99 10 875 880 20060000 10.5631/jibirin.99.875 2-s2.0-33750303046 read0013690/published_papers/15122935 東 貴弘 戸田 直紀 Katsuhiko Nakamura 中村 克彦 Noriaki Takeda 武田 憲昭 末梢性顔面神経麻痺後に発症したGuillain-Barre症候群の1例 Facial Nerve Research Japan 0914-790X 25 114 116 20051210 read0013690/published_papers/15122934 Katsuhiko Nakamura 中村 克彦 高橋 美香 Seizo Oyama 大山 晴三 Naoki Toda 戸田 直紀 東 貴弘 Noriaki Takeda 武田 憲昭 ボツリヌス治療とバイオフィードバック療法の併用による病的共同運動の治療 Facial Nerve Research Japan 0914-790X 25 144 146 20051210 read0013690/published_papers/15122933 戸田 直紀 東 貴弘 高橋 美香 Katsuhiko Nakamura 中村 克彦 Noriaki Takeda 武田 憲昭 Hunt症候群における内耳道造影MRIの検討 Facial Nerve Research Japan 0914-790X 25 105 107 20051210 read0013690/published_papers/15122786 M Ikeda T Aiba A Ikui A Inokuchi Y Kurono M Sakagami N Takeda H Tomita Taste disorders: a survey of the examination methods and treatments used in Japan ACTA OTO-LARYNGOLOGICA 0001-6489 125 11 1203 1210 20051100 10.1080/00016480510040173 16353402 read0013690/published_papers/15122785 M Ando K Sawada H Sakata-Haga YG Jeong N Takeda Y Fukui Regional difference in corticotropin-releasing factor immunoreactivity in mossy fiber terminals innervating calretinin-immunoreactive unipolar brush cells in vestibulocerebellum of rolling mouse Nagoya BRAIN RESEARCH 0006-8993 1063 1 96 101 20051100 10.1016/j.brainres.2005.09.018 16256961 read0013690/published_papers/15122788 K Miyazaki N Takeda N Ishimaru F Omotehara R Arakaki Y Hayashi Analysis of in vivo role of alpha-fodrin autoantigen in primary Sjogren's syndrome AMERICAN JOURNAL OF PATHOLOGY 0002-9440 167 4 1051 1059 20051000 10.1016/S0002-9440(10)61194-7 16192640 read0013690/published_papers/15122787 T Kitahara N Takeda S Nishiike S Okumura T Kubo Prognosis of inner ear periphery and central vestibular plasticity in sudden deafness with vertigo ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY 0003-4894 114 10 786 791 20051000 16285269 read0013690/published_papers/15122790 Kazunori Sekine 関根 和教 佐藤 豪 Noriaki Takeda 武田 憲昭 大学病院におけるめまい症例の統計的検討とめまい疾患の診断基準の問題点 Subjects were 626 patients reporting vertigo or dizziness seen at the University Hospital Department of Otolaryngology from April 2001 to September 2003. Patients were diagnosed based on diagnostic criteria prescribed by the Japan Society for Equilibrium Research. The most common peripheral vestibular disorder was benign paroxysmal positional vertigo (32%), followed by Meniere&#039;s disease (12%). All peripheral vestibular disorders accounted for 65%. Central vestibular disorder accounted for 7%, of which space-occupying lesions in the posterior fossa accounted for 1.0% and cerebral infarction 1.9%. Dizziness due to orthostatic hypotension accounted for 4.0%. Among past reports on clinical statistics of vertigo, the incidence of vertigo and dizziness disorders differed greatly, but our research and the past 2 reports based on diagnostic criteria prescribed by the Japan Society for Equilibrium Research showed almost the same incidence, i. e., BPPV of 30-40%, Meniere&#039;s disease of 7-10%, other peripheral vestibular disorders of 15-20%, and central vestibular disorder of 6-8%. Unified diagnostic criteria are thus important in the statistical analysis of vertigo disorders. Journal of Otolaryngology of Japa 日本耳鼻咽喉科学会会報 0030-6622 108 9 842 849 20050920 10.3950/jibiinkoka.108.842 read0013690/published_papers/15122791 西池 季隆 北原 糺 依藤 史郎 Noriaki Takeda 武田 憲昭 めまい発作に伴い左右側方注視眼振が周期性に変化した特異な1症例 We report on a case with periodic nystagmus on lateral gaze during vertigo attack. The case is a 19-year-old woman who had repeated vertigo attacks in the early stage of the disease. During remission, she had continuous nystagmus on lateral gaze with a large amplitude. During vertigo attack, she had periodic nystagmus with a small amplitude on lateral gaze with null periods of 8s. At onset, her tentative diagnosis was spinocerebellar degeneration such as dentatorubral-pallidoluysian atrophy because of brain stem tegmentum and cerebellar vermis atrophy identified on MRI, but brainstem encephalitis and cerebellitis couldnt be excluded. Periodic nystagmus during vertigo attack may be induced by the depression of higher neural control which was indicated by lesions in the cerebellar vermis shown on MRI. Equilibrium Research 0385-5716 64 3 157 163 20050601 10.3757/jser.64.157 read0013690/published_papers/15122793 長嶋 比奈美 宇高 ニ良 近藤 英二 Noriaki Takeda 武田 憲昭 重複障害児に対する聴性定常反応を用いた骨導検査と音場検査の試み Audiology Japan 0303-8106 48 2 165 173 20050428 10.4295/audiology.48.165 read0013690/published_papers/15122792 H Akizuki A Uno K Arai S Morioka S Ohyama S Nishiike K Tamura N Takeda Effects of immersion in virtual reality on postural control NEUROSCIENCE LETTERS 0304-3940 379 1 23 26 20050400 10.1016/j.neulet.2004.12.041 15814192 read0013690/published_papers/15122794 Takao Imai Noriaki Takeda Atsuhko Uno T Matsunaga Kazunori Sekine Kubo Takeshi Natural course of the remission of vertigo in patients with benign paroxysmal positional vertigo The authors assessed the natural course of benign paroxysmal positional vertigo (BPPV) in 108 patients who were not treated with canalith repositioning procedure. The average number of days from onset to remission of positional vertigo in patients with posterior canal BPPV (P-BPPV) (39 days) was longer than in those with horizontal canal BPPV (H-BPPV) (16 days). The ratio of patients with H-BPPV to those with BPPV was 33%. Neurology 1526-632X 64 5 920 921 20050308 10.1212/01.WNL.0000152890.00170.DA 15753441 read0013690/published_papers/15122795 T Imai K Sekine K Hattori N Takeda Koizuka, I K Nakamae K Miura H Fujioka T Kubo Comparing the accuracy of video-oculography and the scleral search coil system in human eye movement analysis AURIS NASUS LARYNX 1879-1476 32 1 3 9 20050300 10.1016/j.anl.2004.11.009 15882818 read0013690/published_papers/15122798 Noriaki Takeda 武田 憲昭 Kazunori Sekine 関根 和教 上枝 仁美 Gou Satou 佐藤 豪 メニエール病の難聴の長期予後 平成16年度厚生労働省科学研究補助金 特定疾患対策研究事業 前庭機能異常に関する調査研究報告書 102 103 20050000 read0013690/published_papers/15122797 Noriaki Takeda 武田 憲昭 Gou Satou 佐藤 豪 Kazunori Sekine 関根 和教 良性発作性頭位めまい症における眼振の性状と治癒期間 平成16年度厚生労働省科学研究補助金 特定疾患対策研究事業 前庭機能異常に関する調査研究報告書 104 105 20050000 read0013690/published_papers/15122796 N Toda K Nakamura N Takeda Blink reflex R2 recovery curves in patients with facial palsy within ten days after onset ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES 0301-1569 67 1 16 22 20050000 10.1159/000083009 15637417 read0013690/published_papers/15122789 Kazunori Matsuda 松田 和徳 Noriaki Takeda 堀 洋二 Yohji Hori 雫 治彦 Haruhiko Shizuku 武田 憲昭 Screening of sleep apnea syndrome using subjective sleepiness evaluation, ESS 自覚的眠気評価法Epworth Sleepiness Scale(ESS)の有用性 ─睡眠時無呼吸症候群のスクリーニング─ Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 98 10 809 814 20050000 10.5631/jibirin.98.809 2-s2.0-26644452065 read0013690/published_papers/15122784 K Sekine K Morita K Masuda G Sato K Rokutan N Takeda Microarray analysis of stress-related gene expression in patients with Meniere's disease ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES 0301-1569 67 5 294 299 20050000 10.1159/000089411 16374063 read0013690/published_papers/15122937 中村 克彦 戸田 直紀 武市 美香 Noriaki Takeda 武田 憲昭 EVALUATION OF PATHOLOGICAL SYNKINESIS (DEVIATION IN THE POSITION OF THE LIPS AT BLINKING) BY EMPLOYING A BIO-IMPEDANCE METER 生体インピーダンス測定装置による病的共同運動(瞬目時の口唇の偏位)の評価 Facial Nerve Research Japan 0914-790X 24 113 115 20041210 read0013690/published_papers/15122936 戸田 直紀 東 貴弘 中村 克彦 Noriaki Takeda 武田 憲昭 EVALUATION OF ENOG IN THE EARLY STAGE OF FACIAL NERVE PARALYSIS 顔面神経麻痺発症早期ENoGの検討 Facial Nerve Research Japan 0914-790X 24 70 71 20041210 read0013690/published_papers/15122799 N Takeda T Takaoka C Ueda N Toda B Kalubi S Yamamoto Zinc deficiency in patients with idiopathic taste impairment with regard to angiotensin converting enzyme activity AURIS NASUS LARYNX 0385-8146 31 4 425 428 20041200 10.1016/j.anl.2004.09.006 15571918 read0013690/published_papers/15122808 Y Kitamura A Miyoshi Y Murata B Kalubi H Fukui N Takeda Effect of glucocorticoid on upregulation of histamine H-1 receptor mRNA in nasal mucosa of rats sensitized by exposure to toluene diisocyanate ACTA OTO-LARYNGOLOGICA 0001-6489 124 9 1053 1058 20041100 10.1080/00016480410022525 15513549 read0013690/published_papers/15122800 K Sekine T Imai M Morita K Nakamae K Miura H Fujioka T Kubo K Tamura N Takeda Vertical canal function in normal subjects and patients with benign paroxysmal positional vertigo ACTA OTO-LARYNGOLOGICA 0001-6489 124 9 1046 1052 20041100 10.1080/00016480410018061 15513548 read0013690/published_papers/15122801 K Yamamoto MP Ngan N Takeda A Yamatodani JA Rudd Differential activity of drugs to induce emesis and pica behavior in Suncus murinus (house musk shrew) and rats PHYSIOLOGY & BEHAVIOR 0031-9384 83 1 151 156 20041000 10.1016/j.physbeh.2004.08.006 15501502 read0013690/published_papers/15122803 A Horii K Mitani T Kitahara A Uno T Takeda T Kubo Paroxetine, a selective serotonin reuptake inhibitor, reduces depressive symptoms and subjective handicaps in patients with dizziness OTOLOGY & NEUROTOLOGY 1531-7129 25 4 536 543 20040700 10.1097/00129492-200407000-00022 15241233 read0013690/published_papers/15122805 K Sekine T Imai K Nakamae K Miura H Fujioka N Takeda Dynamics of the vestibulo-ocular reflex in patients with the horizontal semicircular canal variant of benign paroxysmal positional vertigo ACTA OTO-LARYNGOLOGICA 0001-6489 124 5 587 594 20040600 10.1080/00016480310002131 15267177 read0013690/published_papers/15122804 北原 糺 Noriaki Takeda 武田 憲昭 肥塚 泉 荻野 仁 メニエール病に対する浸透圧利尿薬の長期連続投与の治療効果と蝸電図におよぼす影響 We treated 7 cases of Meniere&#039;s disease with an oral osmotic diuretic, isosorbide, at a dose of 90 ml per day for more than one year (mean: 31.7 months). One case suffered from bilateral Meniere&#039;s disease. The long-term administration of constant daily amounts of isosorbide attained good long-term results in vertigo but poor in hearing according to the criteria of the Japan Society for Equilibrium Research for Meniere&#039;s disease. The results were as follows: the administration of isosorbide completely controlled vertigo in 29% and improved it in 42%, however, hearing was unchanged in 71% and worsened in 29%. To see if long-term follow-up of Meniere&#039;s patients using electro-cochleogram (ECoG) is useful for determination of therapeutic effects of isosorbide and establishment of its effective medication protocol, we examined relation-ships between long-term results of oral medication of isosorbide and the medication-induced changes in dominant -SP of ECoG. All eight affected ears of seven cases showed dominant -SP at their first visit and half of them didn&#039;t show it anymore after the long-term medication. There was no significant relationship between normalization of ECoG findings and improvement of vertigo. These findings indicate that normalization of ECoG findings cannot be a good marker for determination of therapeutic effects of isosorbide or establishment of its effective medication protocol. Equilibrium Research 0385-5716 63 3 237 241 20040601 10.3757/jser.63.237 read0013690/published_papers/15122939 Y Kitamura A Miyoshi Y Murata K Maeyama N Takeda H Fukui Increase in the level of histidine decarboxylase mRNA expression in nasal mucosa of rats sensitized by toluene diisocyanate INFLAMMATION RESEARCH 1023-3830 53 Suppl 1 S13 S14 20040300 10.1007/s00011-003-0305-6 15054596 read0013690/published_papers/15122938 Y Murata A Miyoshi Y Kitamura N Takeda H Fukui Up-regulation of histamine H-1 receptors in an allergic rat nasal mucosa model INFLAMMATION RESEARCH 1023-3830 53 Suppl 1 S11 S12 20040300 10.1007/s00011-003-0304-7 15054595 read0013690/published_papers/15122806 Kazuhiko Sawada Masahiro Ando Hiromi Sakata-Haga Xue-Zhi Sun Young-Gil Jeong Setsuji Hisano Noriaki Takeda Yoshihiro Fukui Abnormal expression of tyrosine hydroxylase not accompanied by phosphorylation at serine 40 in cerebellar Purkinje cells of ataxic mutant mice, rolling mouse Nagoya and dilute-lethal Congenital Anomalies 0914-3505 44 1 46 50 20040300 10.1111/j.1741-4520.2003.00008.x 15008900 read0013690/published_papers/15122943 安藤 正裕 Kazuhiko Sawada 澤田 和彦 Hiromi Sakata-Haga 坂田 ひろみ Yoshihiro Fukui 福井 義浩 Noriaki Takeda 武田 憲昭 ローリングマウス小脳におけるカルレチニン陽性 unipolar brush cell と CRF 陽性苔状線維終末 頭頚部自律神経 18 53 55 20040000 read0013690/published_papers/15122942 北村 嘉章 村田 有希 荻野 敏 福井 裕行 Noriaki Takeda 武田 憲昭 TDI感作ラットにおけるヒスタミンH1受容体，ヒスチジン脱炭酸酵素発現 頭頚部自律神経 18 21 23 20040000 read0013690/published_papers/15122941 武市 美香 中村 克彦 Yoshihiro Fukui 福井 義浩 Noriaki Takeda 武田 憲昭 外耳道に生じたリンパ腫様丘疹症例 Otolaryngology-Head and Neck Surgery 耳鼻咽喉科・頭頸部外科 76 918 919 20040000 read0013690/published_papers/15122940 武市 美香 戸田 直紀 中村 克彦 Noriaki Takeda 武田 憲昭 眼裂比を用いた病的共同運動の評価 Facial Nerve Research Japan 0914-790X 24 117 119 20040000 read0013690/published_papers/15122810 荻野 敏 Noriaki Takeda 武田 憲昭 原田 保, 他 The effect of centirizine prophylactic treatment on the quality of life in patients with Japanese cedar pollinosis. The 3rd report スギ花粉症患者に対する塩酸セチリジン初期投与の有用性(第3報) Otologia Fukuoka 耳鼻と臨床 0447-7227 50 28 36 20040000 10.11334/jibi1954.50.1_28 read0013690/published_papers/15122809 荻野 敏 Noriaki Takeda 武田 憲昭 原田 保, 他 スギ花粉症患者に対する塩酸セチリジン初期投与の有用性(第4報) Otologia Fukuoka 耳鼻と臨床 0447-7227 50 361 364 20040000 10.11334/jibi1954.50.5_361 read0013690/published_papers/15122802 Reiko Kobayashi 小林 礼子 Rumi Kanbara 西池 季隆 Takeshi Kubo 神原 留美 Suetaka Nishiike 荻野 仁 Hitoshi Ogino 久保 武 Noriaki Takeda 武田 憲昭 A case report of localized Wegener's granulomatosis presenting as otitis media 耳症状初発の限局型Wegener肉芽腫症例 Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 97 8 685 690 20040000 10.5631/jibirin.97.685 2-s2.0-4243139566 read0013690/published_papers/15122811 辻 美由起 西池 季隆 Noriaki Takeda 武田 憲昭 耳閉感と内リンパ水腫 Between 1993 and 1995, 178 patients complaining of fullness of the ear visited our clinic. Of these, 24 were found to have low-tone sensorineural hearing loss. Glycerol test revealed positive/ pseudopositive results in 20 of these 24 cases. Of these, 15 cases were followed up more than 3 years. Average hearing level at low-tone (125 Hz, 250 Hz and 500 Hz) in the 24 hearing-impaired patients were 34.0 dB. Clinical symptoms and low-tone sensorineural hearing loss of all patients were improved by isosorbide or betamethasone. The subjects who had temporary hearing impairment at 4, 000 Hz or 8, 000 Hz had significantly higher risk of recurrence. One findings suggested that low-tone deafness with a chief complaint of ear fullness is caused by endolymphatic hydrops. Prognosis may be dependent on the extent rather than the degree of the impairment in the inner ear. Prompt treatment and follow-up is important for patients who complain ear fullness, because some of them may progress to Meniere disease in the future. Equilibrium Research 0385-5716 62 6 569 574 20031201 10.3757/jser.62.569 read0013690/published_papers/15122944 K Naoi K Nakamae H Fujioka T Imai K Sekine N Takeda T Kubo Three-dimensional eye movement simulator extracting instantaneous eye movement rotation axes, the plane formed by rotation axes, and innervations for eye muscles IEICE TRANSACTIONS ON INFORMATION AND SYSTEMS 0916-8532 E86D 11 2452 2462 20031100 read0013690/published_papers/15122812 A Nakagawa A Uno A Horii T Kitahara M Kawamoto Y Uno M Fukushima S Nishiike N Takeda T Kubo Fos induction in the amygdala by vestibular information during hypergravity stimulation BRAIN RESEARCH 0006-8993 986 1-2 114 123 20031000 10.1016/S0006-8993(03)03220-7 12965235 read0013690/published_papers/15122814 M Morita T Imai S Kazunori N Takeda L Koizuka A Uno T Kitahara T Kubo A new rotational test for vertical semicircular canal function AURIS NASUS LARYNX 0385-8146 30 3 233 237 20030800 10.1016/S0385-8146(03)00098-1 12927284 read0013690/published_papers/15122813 Takuma Sekita 関田 拓馬 Junji Koda 幸田 純治 Hironori Masuda 増田 博範 Kazunori Sekine 関根 和教 Jiro Udaka 宇高 二良 Naoya Takeda 武田 直也 Katuhiko Nakamura 中村 克彦 Noriaki Takeda 武田 憲昭 Two Cases of Laryngeal Palsy Caused by Varicella-Zoster Virus 水痘帯状疱疹ウイルスによる喉頭麻痺の2例 We report two cases of vocal fold paralysis due to varicella-zoster virus infection. Both patients complained of otalgia and hoarseness and the serum antibody titers for varicella-zoster virus were significantly elevated. Neither patient showed facial palsy, and laryngeal electromyography showed reduced recruitment patterns in cricothyroid muscles and thyroarytenoid muscles on the affected side. These findings indicated the paralysis of the vagus nerve, but not the recurrence nerve. Acyclovir was administrated in both cases and the patients recovered from vocal fold paralysis within 3 months. The Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 96 8 717 721 20030801 10.5631/jibirin.96.717 read0013690/published_papers/15122815 Tsukasa Takaoka 高岡 司 Katsuhiko Nakamura 中村 克彦 Katsushi Miyazaki 宮崎 かつし Masahiro Ando 安藤 正裕 Chisa Harada 原田 知佐 Masakazu Goda 合田 正和 Noriaki Takeda 武田 憲昭 A Case of Calcific Retropharyngeal Tendinitis with a Differential Diagnosis of Retropharyngeal Abscess 咽後膿瘍と鑑別を要した切開沈着性長頸筋炎例 We report a case of Calcific retropharyngeal tendinitis that was difficult to distinguish from retropharyngeal abscess. The patient was a 36-year-old woman who complained of severe cervical pain. Clinical findings of moderately elevated WBC count and MRI findings of fluid filling the retropharyngeal space suggested retropharyngeal abscess. However, the patient was not very sick, without high fever or sore throat. CT scan showed a clump of calcification in front of the C1-C2 cervical spines, which is characteristic of calcific retropharyngeal tendinitis. Emergency drainage operation was avoided and the patient fully recovered after treatment by NSAIDs. The Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 96 7 637 640 20030701 10.5631/jibirin.96.637 read0013690/published_papers/15122819 K Nakamura N Toda K Sakamaki K Kashima N Takeda Biofeedback rehabilitation for prevention of synkinesis after facial palsy OTOLARYNGOLOGY-HEAD AND NECK SURGERY 0194-5998 128 4 539 543 20030400 10.1016/mhn.2003.39 12707658 read0013690/published_papers/15122818 T Kitahara K Kondoh T Morihana S Okumura A Horii N Takeda T Kubo Steroid effects on vestibular compensation in human NEUROLOGICAL RESEARCH 0161-6412 25 3 287 291 20030400 10.1179/016164103101201364 12739240 read0013690/published_papers/15122817 H Akiduki S Nishiike H Watanabe K Matsuoka T Kubo N Takeda Visual-vestibular conflict induced by virtual reality in humans NEUROSCIENCE LETTERS 0304-3940 340 3 197 200 20030400 10.1016/S0304-3940(03)00098-3 12672540 read0013690/published_papers/15122950 西池 季隆 中川 誠司 渡辺 洋 山口 雅彦 外池 光雄 Noriaki Takeda 武田 憲昭 中川 あや 久保 武 Optical flowの脳内処理過程 頭頚部自律神経 17 10 125 20030000 read0013690/published_papers/15122949 Noriaki Takeda 武田 憲昭 関根 和教 今井 貴夫 良性発作性頭位めまい症の半規管動特性 厚生労働省科学研究補助金，特定疾患対策研究事業，前庭機能異常に関する調査研究報告書 104 105 20030000 read0013690/published_papers/15122948 Noriaki Takeda 武田 憲昭 辻 美由起 耳閉感と内リンパ水腫 厚生労働省科学研究補助金，特定疾患対策研究事業，前庭機能異常に関する調査研究報告書 106 107 20030000 read0013690/published_papers/15122947 中村 克彦 東 貴弘 武市 美香 上枝 仁美 Noriaki Takeda 武田 憲昭 病的共同運動の発症を予防するためのバイオフィードバック療法の開始時期と訓練期間について Facial Nerve Research Japan 0914-790X 23 174 176 20030000 read0013690/published_papers/15122946 武市 美香 東 貴弘 上枝 仁美 中村 克彦 Noriaki Takeda 武田 憲昭 末梢性顔面神経麻痺後の後遺症発症患者のQOL Facial Nerve Research Japan 0914-790X 23 168 170 20030000 read0013690/published_papers/15122945 東 貴弘 戸田 直紀 武市 美香 上枝 仁美 中村 克彦 Noriaki Takeda 武田 憲昭 頭部外傷後の大錐体神経障害による味覚障害の1例 Facial Nerve Research Japan 0914-790X 23 158 159 20030000 read0013690/published_papers/15122823 荻野 敏 Noriaki Takeda 武田 憲昭 原田 保, 他 スギ花粉症患者における塩酸セチリジン初期投与の有用性(第2報) Otologia Fukuoka 耳鼻と臨床 0447-7227 49 118 124 20030000 10.11334/jibi1954.49.2_118 read0013690/published_papers/15122822 高石 司 阿部 真琴 Noriaki Takeda 武田 憲昭 ムンプス不顕感染によりめまい，難聴をきたした3歳児の症例 We report the case of a young child suffering from vertigo and hearing loss caused by asymptomatic mumps.<BR>A three-year-old boy showed loss of body balance and vomiting. There was no swelling of the parotid glands and he did not complain of hearing loss, but we found he had spontaneous nystagmus to the left. During the medical examination, he staggered to the right from the standing position. After ABR testing, we found abnormality of his right ear and the testing showed high indices of mumps IgM and IgG. CT findings suggested tympanitis in his left ear, but no such sign was seen in the right. As a result of these tests we diagnosed asymptomatic mumps causing dizziness and hearing loss. Four months after he became ill, we found his spontaneous nystagmus had disappeared, but after head shaking nystagmus testing, nystagmus to the left was still observed. Subsequently, we observed that the patient often ran in the opposite direction from which his name was called.<BR>It is very rare for young children to complain of dizziness and vertigo. We should be aware that some children with hearing loss may not complain of symptoms. Physi-cians must also keep in mind that inner ear disorders can be caused by asymptomatic mumps. The number of mumps infections is on the increase. This disease is very hard to cure, so vaccination against mumps needs to be encouraged. Japan Society for Equilibrium Research Equilibrium Research 0385-5716 62 3 199 204 20030000 10.3757/jser.62.199 read0013690/published_papers/15122821 Masahiro Ando 安藤 正裕 Kazuhiko Sawada 澤田 和彦 Hiromi Sakata-Haga 坂田 ひろみ Yoshihiro Fukui 福井 義浩 Noriaki Takeda 武田 憲昭 ローリングマウス小脳におけるカルレチニン陽性unipolar brush cellとCRF陽性苔状線 頭頚部自律神経 18 53 55 20030000 read0013690/published_papers/15122820 Chisa Harada 原田 知佐 Kazunori Sekine 関根 和教 Koichi Tamura 田村 公一 Koji Kimoto 記本 晃治 Naoki Toda 戸田 直紀 Hitoshi Ikushima 生島 仁史 Noriaki Takeda 武田 憲昭 Radiation therapy for middle ear carcinoma; A report of three cases 放射線治療を行った中耳癌の3症例 Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 96 3 201 206 20030000 10.5631/jibirin.96.201 2-s2.0-0037231909 read0013690/published_papers/15122816 Naoki Toda 戸田 直紀 Katsuhiko Nakamura 中村 克彦 Takahiro Azuma 東 貴弘 Katsushi Miyazaki 宮崎 かつし Noriaki Takeda 武田 憲昭 Long-term prognosis of vertigo and hearing loss in Ramsay Hunt syndrome ハント症候群におけるめまいと難聴の長期予後 Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 96 5 405 409 20030000 10.5631/jibirin.96.405 2-s2.0-0038245301 read0013690/published_papers/15122953 中村 克彦 戸田 直紀 Katsushi Miyazaki 宮崎 かつし 東 貴弘 武市 美香 Noriaki Takeda 武田 憲昭 ボツリヌス治療とバイオフィードバック療法の併用による病的共同運動の治療 Facial Nerve Research Japan 0914-790X 22 0 161 163 20021210 read0013690/published_papers/15122952 東 貴弘 中村 克彦 武市 美香 戸田 直紀 Katsushi Miyazaki 宮崎 かつし Noriaki Takeda 武田 憲昭 病的共同運動の発症を予防するためのバイオフィードバック療法の適応について Facial Nerve Research Japan 0914-790X 22 0 158 160 20021210 read0013690/published_papers/15122951 戸田 直紀 中村 克彦 東 貴弘 Katsushi Miyazaki 宮崎 かつし Noriaki Takeda 武田 憲昭 Ramsay Hunt 症候群におけるめまいと難聴の長期予後 Facial Nerve Research Japan 0914-790X 22 0 123 125 20021210 read0013690/published_papers/15122825 T Imai N Takeda A Uno M Morita Koizuka, I T Kubo Three-dimensional eye rotation axis analysis of benign paroxysmal positioning nystagmus ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES 0301-1569 64 6 417 423 20021100 10.1159/000067567 12499766 read0013690/published_papers/15122824 JA Rudd K Yamamoto A Yamatodani N Takeda Differential action of ondansetron and dexamethasone to modify cisplatin-induced acute and delayed kaolin consumption ("pica") in rats EUROPEAN JOURNAL OF PHARMACOLOGY 0014-2999 454 1 47 52 20021100 10.1016/S0014-2999(02)02472-X read0013690/published_papers/15122826 K Yamamoto N Takeda A Yamatodani Establishment of an animal model for radiation-induced vomiting in rats using pica JOURNAL OF RADIATION RESEARCH 0449-3060 43 2 135 141 20020600 10.1269/jrr.43.135 12238327 read0013690/published_papers/15122827 北原 糺 堀井 新 三代 康雄 福嶋 宗久 近藤 千雅 奥村 新一 Noriaki Takeda 武田 憲昭 久保 武 内リンパ嚢高濃度ステロイド挿入術と血中内耳関連ホルモン動態 Journal of Otolaryngology of Japa 日本耳鼻咽喉科学会会報 0030-6622 105 5 557 563 20020520 10.3950/jibiinkoka.105.5_557 read0013690/published_papers/15122828 K Yamamoto S Matsunaga M Matsui N Takeda A Yamatodani Pica in mice as a new model for the study of emesis METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY 0379-0355 24 3 135 138 20020400 10.1358/mf.2002.24.3.802297 12087874 read0013690/published_papers/15122955 北原 糺 中川 あや 福島 宗久 堀井 新 奥村 新一 Noriaki Takeda 武田 憲昭 久保 武 Bechtrew's現象と中枢前庭神経回路 頭頚部自律神経 16 43 46 20020000 read0013690/published_papers/15122954 Noriaki Takeda 武田 憲昭 合田 正和 堀 洋二 Amyloidosis of the Tongue 舌アミロイドーシス The Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 95 8 774 775 20020000 10.5631/jibirin.95.774 read0013690/published_papers/15122829 荻野 敏 Noriaki Takeda 武田 憲昭 原田 保, 他 The effect of cetirizine prophylactic treatment for patients with Japanese cedar pollinosis スギ花粉症患者における塩酸セチリジン初期投与の有用性(第1報) Otologia Fukuoka 耳鼻と臨床 0447-7227 48 6 421 431 20020000 10.11334/jibi1954.48.6_421 read0013690/published_papers/15122830 K Sawada H Sakata-Haga M Ando N Takeda Y Fukui An increased expression of Ca2+ channel alpha(1A) subunit immunoreactivity in deep cerebellar neurons of rolling mouse Nagoya NEUROSCIENCE LETTERS 0304-3940 316 2 87 90 20011200 10.1016/S0304-3940(01)02373-4 11742722 read0013690/published_papers/15122831 S Nishiike A Uno T Kubo A Yamatodani N Takeda S Nakamura Effect of AF64A, a cholinergic neurotoxin, on footshock stimulation-induced locus coeruleus excitation in rats NEUROSCIENCE LETTERS 0304-3940 302 1 33 36 20010400 10.1016/S0304-3940(01)01642-1 11278105 read0013690/published_papers/15122832 T Kitahara N Takeda Y Mishiro T Saika M Fukushima S Okumura T Kubo Effects of exposing the opened endolymphatic sac to large doses of steroids to treat intractable Meniere's disease ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY 0003-4894 110 2 109 112 20010200 11219515 read0013690/published_papers/15122960 S. Nishiike S. Nakagawa M. Tonoike N. Takeda T. Kubo Information processing of visually-induced apparent self motion in the cortex of humans: Analysis with magnetoencephalography Acta Oto-Laryngologica, Supplement 0365-5237 545 545 113 115 20010000 11677722 2-s2.0-0034740970 read0013690/published_papers/15122959 Suetaka Nishiike Noriaki Takeda Takeshi Kubo Shoji Nakamura Noradrenergic pathways involved in the development of vertigo and dizziness--a review In this study, vestibular caloric stimulation (CS) inhibited noradrenergic (NA) neurons of the locus coeruleus (LC) in rats. The vestibular input can be modified by the ventrolateral medulla (VLM), which then inhibits the LC neuronal activity via GABAA receptors. Clinically, CS induces vertigo in humans. Thus, LC-NA inhibition may be involved in the development of vertigo. Moreover, it is speculated that Sopite syndrome, one of the major symptom complexes of motion sickness, is also evoked by LC-NA inhibition. The central LC-NA neuronal system may participate in vertigo and motion sickness independent of the histaminergic neuronal system. In contrast, the cholinergic neuronal system may mediate LC-NA inhibition during the vestibulo-atonomic reflex. The LC-NA system projects to most higher centers and affects sensory information processing. Therefore, it is suggested that the suppression of sensory information processing induced by LC-NA inhibition causes drowsiness, one of the major symptoms of vertigo and motion sickness. It is also speculated that LC-NA inhibition participates in the development of sensory mismatch during vertigo and motion sickness. Acta Oto-Laryngologica. Supplementum. 0365-5237 545 61 64 20010000 10.1080/000164801750388135 11677745 read0013690/published_papers/15122958 中村 克彦 戸田 直紀 Noriaki Takeda 武田 憲昭 顔面神経麻痺後の病的共同運動の予防 Facial Nerve Research Japan 0914-790X 21 134 135 20010000 read0013690/published_papers/15122957 中村 克彦 戸田 直紀 Noriaki Takeda 武田 憲昭 末梢性顔面神経麻痺の発症早期における瞬目煩瑣の興奮性の検討 Facial Nerve Research Japan 0914-790X 21 70 71 20010000 read0013690/published_papers/15122956 北原 糺 福島 宗久 Noriaki Takeda 武田 憲昭 雑賀 孝昇 宇野 敦彦 奥村 新一 久保 武 前庭代償過程におけるcholinergic mossy fiberの役割 頭頚部自律神経 15 32 35 20010000 read0013690/published_papers/15122836 北原 糺 Noriaki Takeda 武田 憲昭 近藤 千雅 森鼻 哲生 奥村 新一 三代 康雄 福嶋 宗久 久保 武 メニエール病に対する内リンパ嚢局所ステロイド暴露による長期治療成績 Journal of Otolaryngology of Japa 日本耳鼻咽喉科学会会報 0030-6622 104 728 734 20010000 10.3950/jibiinkoka.104.728 read0013690/published_papers/15122835 北原 糺 Noriaki Takeda 武田 憲昭 西池 季隆 宇野 敦彦 福嶋 宗久 奥村 新一 久保 武 前庭神経炎にたいするステロイド治療の効果に関する検討 Journal of Otolaryngology of Japa 日本耳鼻咽喉科学会会報 0030-6622 104 1059 1064 20010000 10.3950/jibiinkoka.104.1059 read0013690/published_papers/15122834 立花 文寿 Noriaki Takeda 武田 憲昭 Costen症候群 Equilibrium Research 0385-5716 60 3 195 195 20010000 read0013690/published_papers/15122833 Naoki Toda 戸田 直紀 Katsuhiko Nakamura 中村 克彦 Noriaki Takeda 武田 憲昭 末梢性顔面神経麻痺の発症早期における瞬目反射の興奮性の検討 Facial Nerve Research Japan 0914-790X 21 70 72 20010000 read0013690/published_papers/15122961 戸田 直紀 中村 克彦 岩崎 英隆 酒巻 孝一郎 Noriaki Takeda 武田 憲昭 EARLY DIAGNOSIS OF RAMSAY HUNT SYNDROME : SIGNIFICANCE OF SCHIRMER'S TEST Hunt 症候群の早期診断について:流涙検査法の意義 Facial Nerve Research Japan 0914-790X 20 68 69 20001210 read0013690/published_papers/15122838 T Kitahara M Fukushima N Takeda T Saika T Kubo Effects of pre-flocculectomy on Fos expression and NMDA receptor-mediated neural circuits in the central vestibular system after unilateral labyrinthectomy ACTA OTO-LARYNGOLOGICA 0001-6489 120 7 866 871 20001000 10.1080/000164800750061741 11132722 read0013690/published_papers/15122839 Yasuo Mishiro Masafumi Sakagami Shin-Ichi Okumura Noriaki Takeda Takeshi Kubo Postoperative results for cholesteatoma in children Auris Nasus Larynx 0385-8146 27 3 223 226 20000700 10.1016/S0385-8146(00)00059-6 10808109 2-s2.0-0034059769 read0013690/published_papers/15122842 Suetaka Nishiike Noriaki Takeda Atsuhiko Uno Takeshi Kubo Atsushi Yamatodani Shoji Nakamura Cholinergic Influence on Vestibular Stimulation-Induced Locus Coeruleus Inhibition in Rats In our previous study, caloric stimulation (CS) of the vestibular apparatus inhibited noradrenergic neuronal activity in the locus coeruleus (LC) in urethane-anaesthetized rats. Therefore, the inhibition of LC noradrenergic neurons is involved in vestibulo-autonomic responses. Since motion sickness can be cured by scopolamine, cholinergic neuron system may also be involved in vestibulo-autonomic responses. The present study examined the effects of intracerebroventricular injection of ethylcholine mustard aziridinium ion (AF64A), a presynaptic cholinergic neurotoxin, on CS-induced LC inhibition. In AF64A-treated rats, the CS-induced LC inhibition was less pronounced than in normal rats. In a subsequent series of experiments, the intravenous injection of scopolamine blocked the CS-induced LC inhibition. These findings suggest that central cholinergic neurons are associated with noradrenergic neuronal inhibition during the vestibulo-autonomic reflex. Acta Oto-Laryngologica 0001-6489 120 3 404 409 20000300 10.1080/000164800750000649 10894417 read0013690/published_papers/15122963 中村 克彦 戸田 直紀 酒巻 孝一郎 岩崎 英隆 Noriaki Takeda 武田 憲昭 病的共同運動の予防を目的としたバイオフィードバック療法の効果 Facial Nerve Research Japan 0914-790X 20 120 122 20000000 read0013690/published_papers/15122962 北原 糺 Noriaki Takeda 武田 憲昭 奥村 新一 久保 武 前庭小脳グルタミン酸受容体デルタ2の前庭代償への関与 頭頚部自律神経 14 33 35 20000000 read0013690/published_papers/15122841 A Uno N Takeda T Kitahara Y Sakata A Yamatodani T Kubo Effects of vestibular cerebellum lesion on motion sickness in rats ACTA OTO-LARYNGOLOGICA 0001-6489 120 3 386 389 20000000 10.1080/000164800750000612 10894414 read0013690/published_papers/15122840 Tadashi Kitahara 北原 糺 Kazumasa Kondoh 近藤 千雅 Junko Murata 武田 憲昭 Shin-Ichi Okumura 村田 潤子 Noriaki Takeda 奥村 新一 A long-term prognosis of sudden deafness with vertigo; a retrospective study めまいを伴う突発性難聴の平衡障害長期予後 Society of Practical Otolaryngology Practica Otologica 耳鼻咽喉科臨床 0032-6313 93 6 449 454 20000000 10.5631/jibirin.93.449 2-s2.0-0242489007 read0013690/published_papers/15122837 T. Kitahara 北原 糺 N. Takeda 武田 憲昭 Y. Mishiro 三代 康雄 K. Kondoh 近藤 千雅 J. Murata 村田 潤子 S. Okumura 奥村 新一 T. Kubo 久保 武 Vestibular symptoms and ENG findings during periods of convalescence after endolymphatic sac drainage and steroid-instillation surgery (EDSS) 内リンパ嚢高濃度ステロイド挿入術の手術侵襲に伴うめまい経過 Oto-Rhino-Laryngological Society of Japan Inc. Journal of Otolaryngology of Japan 日本耳鼻咽喉科学会会報 0030-6622 103 12 1255 1262 20000000 10.3950/jibiinkoka.103.1255 11197811 2-s2.0-0034523604 read0013690/published_papers/15122843 Koichi Arai 新井 浩一 Shigenobu Furuta 古田 重信 Soukiti Morioka 森岡 荘吉 Hideki Kawabata 川端 秀樹 Yoshihiro Matsumoto 松本 美浩 Toshiro Inui 乾 敏郎 Takashi Hujikado 不二門 尚 Haruo Takemura 竹村 治雄 Noriaki Takeda 武田 憲昭 VR技術を用いたシミュレータの体験時間の検討 An indoor distribution substation simulator for the training of substation maintenance personnel was developed. In this development, the major consideration was focused on what and how the user experiences in the virtual space which was generated by the simulator. And more important consideration was how long the developer can enable the user to experience virtual space without discomfortness or sickness. There are many factors to decide the appropriate experience time and the contents of the simulator. The experience in the virtual space brings various physiological and psychological influences on the users. These effects depend heavily on the environment of each simulator. The physiological and psychological influences on the users in the simulator were experimentally studied. The 40 minutes experience and the experience with delay were done with the simulator. The influences on the sense of sight and the sense of balance, subjective symptoms and the influences of system's delay on the users were measured and considered. THE VIRTUAL REALITY SOCIETY OF JAPAN 特定非営利活動法人 日本バーチャルリアリティ学会 Transactions of the Virtual Reality Society of Japan 日本バーチャルリアリティ学会論文誌 1344-011X 4 4 707 716 19991200 10.18974/tvrsj.4.4_707 read0013690/published_papers/15122845 N Miyazaki T Furuyama M Amasaki H Sugimoto T Sakai N Takeda T Kubo S Inagaki Mouse semaphorin H inhibits neurite outgrowth from sensory neurons NEUROSCIENCE RESEARCH 0168-0102 33 4 269 274 19990400 10.1016/S0168-0102(99)00015-2 10401979 read0013690/published_papers/15122846 三代 康雄 Noriaki Takeda 武田 憲昭 阪上 雅史 北原 糺 梶川 泰 久保 武 再発性真珠腫症例の検討 Thirty nine ears of recurrent cholesteatoma after closed tympnoplasty were reviewed. The mean period between the previous operation and the reoperation was 5.3 years with a range from 2 to 20 years. The mean age at the reoperation was 41.9 years old with a range from 8 to 68 years old. The opposite ear was normal in twenty five ears (64.1%), cholesteatoma in 10 ears (25.6%), otitis media with effusion in 2 ears (5.1%), adhesive otitis media in one ear (2.6%) and chronic suppurative otitis media in one ear (2.6%). In the reoperation, closed tympanoplasty was performed in 13 ears (33.3%), open tympanoplasty in 18 ears (46.2%), total mastoid obliteration in 4 ears (10.3%) and partial mastoid obliteration in 4 ears (10.3%). No cases showed common findings of recurrent cholesteatoma in the previous operation. Recurrent cholesteatoma ocurred again in 2 ears (15.4%) and a deep retraction pocket in 2 ears (15.4%) of 13 ears operated on with closed tympanoplasty in the reoperation. Recurrent cholesteatoma should be operated with open tympanoplasty or mastoid obliteration technique because of the high risk of recurrent cholesteatoma after closed tympanoplasty. Cholesteatoma in the only hearing ear, bilateral ears, aged patients or with medical complications should be operated on with open tympanoplasty in the first operation. To evaluate operative results of closed tympanoplasty needs at least 6 years, because the mean periods between the previous operation and the reoperation was 5.3 years. THE JAPAN OTOLOGICAL SOCIETY Otology Japan 0917-2025 9 1 44 47 19990225 10.11289/otoljpn1991.9.44 read0013690/published_papers/15122847 N Miyazaki T Furuyama N Takeda T Inoue T Kubo S Inagaki Expression of mouse semaphorin H mRNA in the inner ear of mouse fetuses NEUROSCIENCE LETTERS 0304-3940 261 1-2 127 129 19990200 10.1016/S0304-3940(98)00988-4 10081944 read0013690/published_papers/15122964 北原 糺 Noriaki Takeda 武田 憲昭 奥村 新一 木山 博資 久保 武 前庭代償過程における小脳片葉 unipolar brush cell におけるNOの役割 頭頚部自律神経 13 31 32 19990000 read0013690/published_papers/15122850 北原 糺 Noriaki Takeda 武田 憲昭 三代 康雄 村田 潤子 小畠 秀浩 近藤 千雅 奥村 新一 内リンパ嚢開放高濃度ステロイド挿入術 Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 92 607 611 19990000 10.5631/jibirin.92.607 read0013690/published_papers/15122849 Noriaki Takeda 武田 憲昭 神畠 俊子 西池 季隆 坂田 義治 荻野 仁 久保 武 肥塚 泉 中枢性頭位めまい症例 Equilibrium Research 0385-5716 58 209 214 19990000 10.3757/jser.58.209 read0013690/published_papers/15122848 T Kitahara N Takeda T Kubo H Kiyama Nitric oxide in the flocculus works the inhibitory neural circuits after unilateral labyrinthectomy BRAIN RESEARCH 0006-8993 815 2 405 409 19990100 10.1016/S0006-8993(98)01113-5 9878854 read0013690/published_papers/15122844 Takao Imai Noriaki Takeda Masahiro Morita Izumi Koizuka Takeshi Kubo Katsuyoshi Miura Koji Nakamae Hiromu Fujioka Rotation vector analysis of eye movement in three dimensions with an infrared CCD camera Acta Oto-Laryngologica 0001-6489 119 1 24 28 19990000 10.1080/00016489950181882 10219380 2-s2.0-0032976796 read0013690/published_papers/15122851 T Kitahara Tadashi Kitahara N Takeda Noriaki Takeda A Uno Atsuhiko Uno T Kubo Takeshi Kubo M Mishina Takeshi Kubo H Kiyama Masayoshi Mishina Hiroshi Kiyama Unilateral labyrinthectomy downregulates glutamate receptor delta-2 expression in the rat vestibulocerebellum Unilateral labyrinthectomy downregulates glutamate receptor δ-2 expression in the rat vestibulocerebellum MOLECULAR BRAIN RESEARCH Brain Research. Molecular Brain Research 0169-328X 61 1-2 170 178 19981000 10.1016/S0169-328X(98)00228-9 9795202 read0013690/published_papers/15122852 Tadashi Kitahara Noriaki Takeda Takeshi Kubo Hiroshi Kiyama An Implication of Protein Phosphatase 2A-? in the Rat Flocculus for Lesion-induced Vestibular Plasticity The differential display method was applied to identify genes, the expression of which is up-regulated in the cerebellar flocculus after unilateral labyrinthectomy (UL). Total RNA from sham-operated and labyrinthectomized rat flocculi was isolated, amplified by polymerase chain reaction (PCR) using a single arbitrary primer and separated by electrophoresis on a polyacrylamide gel. PCR products in amounts significantly higher in samples from labyrinthectomized animals than in those from controls were cut out of the gel and sequenced. One of the cDNA fragments showed 100% nucleotide sequence identity to the rat protein phosphatase 2A (PP2A)-beta catalytic subunit mRNA. In situ hybridization histochemistry and Northern blot analysis showed that PP2A-beta mRNA expression was intensely localized to the floccular Purkinje cell layer and up-regulated with a maximum increase within 2 days after UL. In labyrinthectomized rats, UL-induced nystagmus gradually disappeared within 3 days after UL. However, in animals with continuous floccular infusion of okadaic acid, a potent inhibitor of PP2A, UL-induced nystagmus lasted significantly longer. All these findings suggest that up-regulation of PP2A-beta mRNA in floccular Purkinje cells after UL is involved in lesion-induced vestibular plasticity. So far, various kinds of neural plasticity-associated molecules have been investigated mainly by slice in vitro studies. This paper indicates that differential display is the feasible molecular biological in vivo method for an investigation about the mechanism of neural plasticity. Acta Oto-Laryngologica 0001-6489 118 5 685 691 19980900 10.1080/00016489850183188 9840505 read0013690/published_papers/15122853 K Noda M Tonoike K Doi Koizuka, I M Yamaguchi R Seo N Matsumoto T Noiri N Takeda T Kubo Auditory evoked off-response: its source distribution is different from that of on-response NEUROREPORT 0959-4965 9 11 2621 2625 19980800 read0013690/published_papers/15122967 Suetaka Nishiike Noriaki Takeda Atsuhiko Uno Takeshi Kubo Atsushi Yamatodani Shoji Nakamura Histaminergic influence on vestibular stimulation-induced locus coeruleus inhibition in rats Acta Oto-Laryngologica, Supplement 0365-5237 539 539 15 18 19980000 10.1080/00016489850182062 10095855 2-s2.0-0032216825 read0013690/published_papers/15122966 Tadashi Kitahara Noriaki Takeda H Kiyama Takeshi Kubo Molecular mechanisms of vestibular compensation in the central vestibular system--review Acta Oto-Laryngologica. Supplementum. 0365-5237 539 19 274 19980000 read0013690/published_papers/15122965 北原 糺 Noriaki Takeda 武田 憲昭 奥村 新一 久保 武 前庭小脳グルタミン酸受容体デルタ2の前庭代償への関与 頭頚部自律神経 12 33 35 19980000 read0013690/published_papers/15122858 神畠 俊子 Noriaki Takeda 武田 憲昭 肥塚 泉 森脇 計博 坂田 義治 荻野 仁 久保 武 上眼瞼向き眼振を認めた Werniche 脳症例 Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 91 775 779 19980000 read0013690/published_papers/15122857 今井 貴夫 守田 雅弘 Noriaki Takeda 武田 憲昭 久保 武 垂直半規管の回転検査 Equilibrium Research 0385-5716 57 322 327 19980000 10.3757/jser.57.322 read0013690/published_papers/15122856 北原 糺 Noriaki Takeda 武田 憲昭 肥塚 泉 西池 季隆 荻野 仁 久保 武 めまいに対するブロマゼパムの治療効果 Equilibrium Research 0385-5716 57 401 407 19980000 10.3757/jser.57.401 read0013690/published_papers/15122855 Noriaki Takeda 武田 憲昭 肥塚 泉 西池 季隆 北原 糺 堀井 新 宇野 敦彦 矢野 裕之 田矢 直三 土井 勝美 荻野 仁 久保 武 遅発性内リンパ水腫症例の臨床的検討 Journal of Otolaryngology of Japa 日本耳鼻咽喉科学会会報 0030-6622 101 1385 1389 19980000 10.3950/jibiinkoka.101.12_1385 read0013690/published_papers/15122854 北原 糺 Noriaki Takeda 武田 憲昭 奥村 新一 久保 武 分子生物学的手法による前庭代償分子機構の解明 The Oto-Rhino-Laryngological Society of Japan, Inc. Journal of Otolaryngology of Japa 日本耳鼻咽喉科学会会報 0030-6622 101 1 37 43 19980000 10.3950/jibiinkoka.101.37 read0013690/published_papers/15122859 T Kitahara N Takeda PC Emson T Kubo H Kiyama Changes in nitric oxide synthase-like immunoreactivities in unipolar brush cells in the rat cerebellar flocculus after unilateral labyrinthectomy BRAIN RESEARCH 0006-8993 765 1 1 6 19970800 10.1016/S0006-8993(97)00436-8 read0013690/published_papers/15122860 A Uno N Takeda A Horii M Morita Y Yamamoto A Yamatodani T Kubo Histamine release from the hypothalamus induced by gravity change in rats and space motion sickness PHYSIOLOGY & BEHAVIOR 0031-9384 61 6 883 887 19970600 10.1016/S0031-9384(96)00613-0 read0013690/published_papers/15122970 北原 糺 Noriaki Takeda 武田 憲昭 久保 武 木山 博資 前庭代償における小脳プロテイン・フォスファターゼ2Aの関与 頭頚部自律神経 11 8 10 19970000 read0013690/published_papers/15122969 Noriaki Takeda 武田 憲昭 北原 糺 前庭代償 Equilibrium Research 0385-5716 306 307 19970000 read0013690/published_papers/15122968 S. Nakamura S. Nishiike Y. Fujii N. Takeda T. Kubo Sensory Response of the Locus Ceruleus: Neonatal and Adult Studies Academic Press Inc. Advances in Pharmacology 1054-3589 42 C 772 776 19970000 10.1016/S1054-3589(08)60861-3 9328012 2-s2.0-77956725710 read0013690/published_papers/15122863 Noriaki Takeda 武田 憲昭 肥塚 泉 西池 季隆 北原 糺 荻野 仁 久保 武 良性発作性頭位めまい症の臨床的検討と耳石器機能 Journal of Otolaryngology of Japa 日本耳鼻咽喉科学会会報 0030-6622 100 449 456 19970000 10.3950/jibiinkoka.100.449 read0013690/published_papers/15122862 Noriaki Takeda 武田 憲昭 北原 糺 肥塚 泉 西池 季隆 守田 雅弘 竹本 市紅 田矢 直三 執行 昭男 藤原 亨 神畠 俊子 荻野 仁 奥村 新一 三好 敏三 久保 武 めまいに対するアメジニウムの効果 The therapeutic effects of amezinium, an indirect sympathomimetic, was evaluated in 71 patients with vertigo or dizziness. The patients were given a 10mg tablet of amezinium two times a day for over four weeks. In 39 patients (54.9%), the symptoms were reduced. Mild side effects were noted in 4 patients (5.6%). These findings suggest that amenizium is a clinically useful drug for the treatment of vertigo or dizziness. The administration of amezinium tended to be more effective in patients with orthostatic dysregulation (OD), as diagnosed by an OD questionnaire and a Schellong test, than in patients without OD. These findings suggest that amezinium improved the sympathetic nervous system dysfunction in these patients, leading to its therapeutic effect. The Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 90 11 1281 1286 19970000 10.5631/jibirin.90.1281 read0013690/published_papers/15122861 T Kitahara N Takeda T Saika T Kubo H Kiyama Role of the flocculus in the development of vestibular compensation: Immunohistochemical studies with retrograde tracing and flocculectomy using Fos expression as a marker in the rat brainstem NEUROSCIENCE 0306-4522 76 2 571 580 19970100 10.1016/S0306-4522(96)00374-0 read0013690/published_papers/15122864 N Takeda A Horii A Uno M Morita T Mochizuki A Yamatodani T Kubo A ground-based animal model of space adaptation syndrome JOURNAL OF VESTIBULAR RESEARCH-EQUILIBRIUM & ORIENTATION 0957-4271 6 6 403 409 19961100 read0013690/published_papers/15122865 T Kitahara N Takeda T Kubo H Kiyama Molecular cloning of the rat NADH:ubiquinone oxidoreductase subunit and its up-regulation in the facial muscle after denervation: Detected by means of differential display NEUROLOGICAL RESEARCH 0161-6412 18 4 329 336 19960800 8875451 read0013690/published_papers/15122971 Arata Horii Noriaki Takeda Atsushi Yamatodani Takeshi Kubo Vestibular influences on the histaminergic and cholinergic systems in the rat brain Annals of the New York Academy of Sciences 0077-8923 781 633 634 19960600 10.1111/j.1749-6632.1996.tb15743.x read0013690/published_papers/15122866 三代 康雄 Noriaki Takeda 武田 憲昭 江崎 光彦 奥村 新一 北村 健 阪上 雅史 久保 武 鼓室形成術III型変法の手術成績 Hearing results of 130 ears operated on by type III tympanoplasty were reviewed. Postoperative air-bone gap was less than 10dB in 70 ears (53.8%) and less than 20dB in 105 ears (80.8%). There was no statistical difference in hearing results between chronic middle otitis with and without cholesteatoma. There was statistical difference in mean postoperative air-bone gap between the cases used ossicles and the cases used cortical temporal bone chips (Post-hoc test, p&lt;0.05). THE JAPAN OTOLOGICAL SOCIETY Otology Japan 0917-2025 6 2 125 128 19960528 10.11289/otoljpn1991.6.125 read0013690/published_papers/15122867 S Nishiike S Nakamura S Arakawa N Takeda T Kubo GABAergic inhibitory response of locus coeruleus neurons to caloric vestibular stimulation in rats BRAIN RESEARCH 1872-6240 712 1 84 94 19960300 10.1016/0006-8993(95)01485-3 read0013690/published_papers/15122972 北原 糺 Noriaki Takeda 武田 憲昭 土井 勝美 岩倉 進 久保 武 木山 博資 GABAA レセプターγ1 ，γ2 サブユニットの前庭神経節における発現 頭頚部自律神経 10 17 19 19960000 read0013690/published_papers/15122874 Noriaki Takeda 武田 憲昭 肥塚 泉 土井 勝美 堀井 新 丹生 真理子 西池 季隆 北原 糺 久保 武 両側および一側レルモワイエ症候群症例と発症機序に関する考察 Two cases of bilateral Lermoyez's syndrome and one case of unilateral Lermoyez's syndrome are reported. The patients had recurrent episodes of vertigo with improvement of hearing or tinnitus, which is characteristic of Lermoyez's syndrome. In case 1, a 48-year-old female, dehydration with glycerol or furosemide induced nystagmus and improved bilateral hearing and the gain of the vestibulo-ocular reflex, while overhydration with drinking water impaired bilateral hearing with disappearance of nystagmus. These findings indicate that she had endolymphatic hydrops in both ears, suggesting that simultaneous changes in bilateral cochlear and vestibular function induce Lermoyez's syndrome. In case 3, a 52-year-old female, which we already reported, endolymphatic collapse in both ears may have changed bilateral inner ear function, resulting in Lermoyez's syndrome. On the other hand, patients 2, a 47-year-old male, experienced a vertigo attack with improvement of unilateral hearing after defibrinogenation therapy. In this case, slowly developing insufficiency of the inner ear blood supply may have caused the gradual hearing loss. It seemed that decreasing blood viscosity by defibrinogenation allowed blood to rush into the labyrinth, causing vertigo but at the same time improving hearing. We proposed that there are two types of Lermoyez's syndrome, bilateral (cases 1 and 3) and unilateral (case 2). 両側レルモワイエ症候群の症例1は, 脱水により聴力と前庭動眼反射の利得が改善したが, 眼振とめまい感が出現した. 両側の内耳に内リンパ水腫が存在し, 両側の蝸牛, 前庭機能が同時に変動することが発症のメカニズムであると推定した. 以前に報告した症例3も両側レルモワイエ症候群と考えられた. 一側レルモワイエ症候群の症例2は, バトロキソビン投与により発作が誘発された. バトロキソビンにより血液粘稠度が低下することで右内耳血流障害が急激に改善し, 右聴力は改善し, 前庭代償が破綻しめまいが発症したものと推定した. レルモワイエ症候群には両側性および一側性の2つの発症機序が存在するものと考えられる. The Oto-Rhino-Laryngological Society of Japan, Inc. Journal of Otolaryngology of Japa 日本耳鼻咽喉科学会会報 0030-6622 99 2 277 285 19960000 10.3950/jibiinkoka.99.277 read0013690/published_papers/15122873 辻 美由起 Noriaki Takeda 武田 憲昭 沢田 徹 肥塚 泉 久保 武 前庭皮質と前庭失認に関する臨床的検討 Equilibrium Research 0385-5716 55 38 43 19960000 10.3757/jser.55.38 read0013690/published_papers/15122872 Noriaki Takeda 武田 憲昭 田矢 直三 中上 哲広 肥塚 泉 川嵜 良明 守田 雅弘 荻野 仁 大和谷 厚 久保 武 松永 亨 起立生低血圧によるめまい症の1例 Equilibrium Research 0385-5716 55 364 370 19960000 10.3757/jser.55.364 read0013690/published_papers/15122871 赤埴 詩朗 Noriaki Takeda 武田 憲昭 竹本 市紅 肥塚 泉 清水 恵司 久保 武 聴力正常の小脳橋角部大腫瘍の2症例 Two patients with large cerebellopontine (CP) angle tumors and normal pure-tone hearing levels are reported. Case 1, a 49-year-old woman, first experienced hearing distortion in her left ear. Case 2, a 45-year-old woman, first experienced numbness at the tip of her tongue, and then noted hearing loss in the left ear. However, their pure-tone audiograms were normal. In both cases, the Bekesy audiogram showed a type III tracing for the left ear, and the results of auditory brainstem response (ABR) testing were abnormal. A CT scan and a MR imaging demonstrated a CP angle tumor of 6×4 cm size in Case 1, and of 3.5×3 cm size in Case 2. The former was a surgically confirmed CP angle meningioma, and the latter was a surgically suspected facial nerve neuroma. These cases emphasize the fact that a large CP angle tumor can be present without affec-ting pure-tone hearing sensitivity. The clinician must be aware that a subjective hearing impair-ment may be the only clues to the presence of a CP angle tumor. ABR is a valuable procedure for detecting CP angles tumors in patients with normal pure-tone hearing. The Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 89 7 787 793 19960000 10.5631/jibirin.89.787 read0013690/published_papers/15122870 守田 雅弘 Noriaki Takeda 武田 憲昭 肥塚 泉 久保 武 垂直半規管刺激性回転後眼振 Equilibrium Research 0385-5716 55 380 386 19960000 10.3757/jser.55.380 read0013690/published_papers/15122869 北村 健 土井 勝美 Noriaki Takeda 武田 憲昭 三代 康雄 大草 方子 久保 武 突発性難聴の治療法による群間検定 Journal of Otolaryngology of Japa 日本耳鼻咽喉科学会会報 0030-6622 90 1676 1683 19960000 10.3950/jibiinkoka.99.1676 read0013690/published_papers/15122868 S Nishiike Noriaki Takeda Takeshi Kubo S Nakamura Effects of caloric vestibular stimulation on prepositus hypoglossi neurons in rats European Archives of Oto-Rhino-Laryngology 253 1-2 52 56 19960100 read0013690/published_papers/15122875 三代 康雄 Noriaki Takeda 武田 憲昭 奥村 新一 北村 健 梶川 泰 阪上 雅史 久保 武 鼓室硬化症の手術成績 Hearing results of 51 ears with tympnaosclerosis were reviewed. Postoperative air-bone gap was less than 10dB in 34 ears (66.7%) and less than 20dB in 46 ears (90.2%). There was no statistical difference in hearing results between type I and type III tympanoplasty. There was statistical difference in hearing results between the eras with and without tympanosclerosis of the stapes. In cases of stapes fixation, the ears with stapedectomy tended to have better hearing results than those without stapedectomy. But there were only 7 ears of tympanosclerosis of stapes, and the experince is needed to further discuss whether stapedectomy is useful or not. THE JAPAN OTOLOGICAL SOCIETY Otology Japan 0917-2025 5 5 583 587 19951225 10.11289/otoljpn1991.5.583 read0013690/published_papers/15122876 Noriaki Takeda S Hasegawa M Morita A Horii A Uno A. Yamatodani Toru Matsunaga Neuropharmacological mechanisms of emesis. II. Effects of antiemetic drugs on cisplatin-induced pica in rats Methods and Findings in Experimental and Clinical Pharmacology 17 10 647 652 19951200 read0013690/published_papers/15122878 Noriaki Takeda S Hasegawa M Morita A Horii A Uno A. Yamatodani Toru Matsunaga Neuropharmacological mechanisms of emesis. I. Effects of antiemetic drugs on motion- and apomorphine-induced pica in rats Methods and Findings in Experimental and Clinical Pharmacology 17 9 589 590 19951100 read0013690/published_papers/15122877 T KITAHARA S KIRYU N TAKEDA T KUBO H KIYAMA UP-REGULATION OF FERRITIN HEAVY-CHAIN MESSENGER-RNA EXPRESSION IN THE RAT SKELETAL-MUSCLE AFTER DENERVATION - DETECTED BY MEANS OF DIFFERENTIAL DISPLAY NEUROSCIENCE RESEARCH 0168-0102 23 4 353 360 19951100 10.1016/0168-0102(95)00963-T read0013690/published_papers/15122973 土井 勝美 Noriaki Takeda 武田 憲昭 久保 武 van der Hoeve 症候群 Molecular Medicine 臨時増刊号 32 338 339 19950415 read0013690/published_papers/15122880 T KUBO K DOI KOIZUKA, I N TAKEDA N SUGIYAMA K YAMADA E KOHMURA T HAYAKAWA ASSESSMENT OF AUDITORY AND VESTIBULAR FUNCTIONS AFTER VESTIBULAR NEURECTOMY FOR MENIERES-DISEASE ACTA OTO-LARYNGOLOGICA 0001-6489 115 2 149 153 19950300 7610792 read0013690/published_papers/15122980 Noriaki Takeda M Tanaka-Tsuji T Sawada Izumi Koizuka Takeshi Kubo Clinical investigation of the vestibular cortex Acta Oto-Laryngologica. Supplementum. 0365-5237 520 Pt 1 110 112 19950000 read0013690/published_papers/15122979 Tadashi Kitahara T Saika Noriaki Takeda Hiroshi Kiyama Takeshi Kubo Changes in Fos and Jun expression in the rat brainstem in the process of vestibular compensation Acta Oto-Laryngologica. Supplementum. 0365-5237 520 Pt 2 401 404 19950000 read0013690/published_papers/15122978 Suetaka Nishiike Noriaki Takeda S Nakamura S Arakawa Takeshi Kubo Responses of locus coeruleus neurons to caloric stimulation in rats Acta Oto-Laryngologica. Supplementum. 0365-5237 520 Pt 1 105 109 19950000 read0013690/published_papers/15122977 Arata Horii Noriaki Takeda T Mochizuki K Okamura-Mochizuki Yumiko Yamamoto Atsushi Yamatodani Takeshi Kubo Vestibular modulation of the septo-hippocampal cholinergic system of rats Acta Oto-Laryngologica. Supplementum. 0365-5237 520 Pt 2 395 398 19950000 read0013690/published_papers/15122976 I Koizuka Masafumi Sakagami Katsumi Doi Noriaki Takeda T Matsunaga Takeshi Kubo Nystagmus measured by ENG after stapes surgery Acta Oto-Laryngologica. Supplementum. 0365-5237 520 Pt 2 258 259 19950000 read0013690/published_papers/15122975 大野 浩司 Noriaki Takeda 武田 憲昭 久保 武 33 神経切断後に認められた顔面神経ニューロンでの cAMP 依存性プロテインキナーゼ発現変化 頭頚部自律神経 9 53 55 19950000 read0013690/published_papers/15122974 Noriaki Takeda 武田 憲昭 めまいと自律神経機能 The Autonomic Nervous System 自律神経 32 13 15 19950000 read0013690/published_papers/15122882 Noriaki Takeda 武田 憲昭 肥塚 泉 河野 幹子 西池 季隆 久保 武 荻野 仁 前庭神経炎の診断および治療における問題点 Journal of Otolaryngology of Japa 日本耳鼻咽喉科学会会報 0030-6622 98 951 958 19950000 10.3950/jibiinkoka.98.951 read0013690/published_papers/15122881 西池 季隆 Noriaki Takeda 武田 憲昭 肥塚 泉 林 治博 久保 武 荻野 仁 めまい患者の日常生活支障度 Journal of Otolaryngology of Japa 日本耳鼻咽喉科学会会報 0030-6622 98 31 40 19950000 10.3950/jibiinkoka.98.31 read0013690/published_papers/15122879 Takashi Okumura 奥村 隆司 Noriaki Takeda 武田 憲昭 Kenji Hattori 服部 賢二 Takeshi Kubo 久保 武 Serotonin 5HT3-Receptor Antagonist for Cisplatin-Induced Nausea and Vomiting CDDP嘔吐に対する坑セロトニン薬の効果 Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 88 8 1101 1106 19950000 10.5631/jibirin.88.1101 2-s2.0-0029153413 read0013690/published_papers/15122883 K OHNO Koji Ohno T KITAHARA T Kitahara N TAKEDA Noriaki Takeda T KUBO Takeshi Kubo H KIYAMA H Kiyama GENE-REGULATION OF CYCLIC-AMP-DEPENDENT PROTEIN-KINASE SUBUNITS (C-ALPHA,BETA, RI-ALPHA,BETA AND RII-ALPHA,BETA) IN RAT FACIAL MOTONEURONS AFTER NERVE TRANSECTION Gene regulation of cyclic amp-dependent protein kinase subunits (Cα,β; RIα, β and RIIα,β) in rat facial motoneurons after nerve transection NEUROSCIENCE Neuroscience 0306-4522 63 4 1101 1109 19941200 10.1016/0306-4522(94)90575-4 read0013690/published_papers/15122884 A HORII N TAKEDA T MOCHIZUKI A OKAKURAMOCHIZUKI Y YAMAMOTO A YAMATODANI EFFECTS OF VESTIBULAR STIMULATION ON ACETYLCHOLINE-RELEASE FROM RAT HIPPOCAMPUS - AN IN-VIVO MICRODIALYSIS STUDY JOURNAL OF NEUROPHYSIOLOGY 0022-3077 72 2 605 611 19940800 read0013690/published_papers/15122885 T KITAHARA Tadashi Kitahara N TAKEDA Noriaki Takeda K OHNO Koji Ohno T ARAKI Toshiyuki Araki T KUBO Takeshi Kubo H KIYAMA Hiroshi Kiyama EXPRESSION OF GABA(A) RECEPTOR GAMMA-1 AND GAMMA-2 SUBUNITS IN THE PERIPHERAL VESTIBULAR SYSTEM OF THE RAT Expression of GABAA receptor γ1 and γ2 subunits in the peripheral vestibular system of the rat BRAIN RESEARCH Brain Research 0006-8993 650 1 157 160 19940700 10.1016/0006-8993(94)90220-8 read0013690/published_papers/15122983 N TAKEDA K YAMAMOTO T KUBO T MATSUNAGA EFFECTS OF ACUTE DECREASE IN SYSTEMIC BLOOD PRESSURE ON CANAL OXYGEN CONCENTRATION AND PER-ROTATIONAL NYSTAGMUS IN GUINEA PIGS WITH ENDOLYMPHATIC HYDROPS MENIERE'S DISEASE 353 356 19940000 read0013690/published_papers/15122982 T MATSUNAGA K YAMAMOTO T KUBO H OGINO K OCHIAI N TAKEDA SYMPATHO-VASCULAR MECHANISM OF VERTIGO ATTACK IN MENIERES DISEASE MENIERE'S DISEASE 77 80 19940000 read0013690/published_papers/15122981 Noriaki Takeda 武田 憲昭 気道過敏性の神経因子 The Japanese Journal of Thoracic Diseases 日本胸部疾患学会雑誌 0301-1542 31 108 114 19940000 read0013690/published_papers/15122886 Noriaki Takeda 武田 憲昭 西池 季隆 田矢 直三 肥塚 泉 荻野 仁 松永 亨 めまいに対するイブジラストの治療効果 Equilibrium Research 0385-5716 536 437 445 19940000 10.3757/jser.53.437 read0013690/published_papers/15122887 A HORII N TAKEDA T MATSUNAGA A YAMATODANI T MOCHIZUKI K OKAKURAMOCHIZUKI H WADA EFFECT OF UNILATERAL VESTIBULAR STIMULATION ON HISTAMINE-RELEASE FROM THE HYPOTHALAMUS OF RATS IN-VIVO JOURNAL OF NEUROPHYSIOLOGY 0022-3077 70 5 1822 1826 19931100 read0013690/published_papers/15122889 N TAKEDA S HASEGAWA M MORITA T MATSUNAGA PICA IN RATS IS ANALOGOUS TO EMESIS - AN ANIMAL-MODEL IN EMESIS RESEARCH PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 0091-3057 45 4 817 821 19930800 10.1016/0091-3057(93)90126-E read0013690/published_papers/15122888 T SAIKA N TAKEDA H KIYAMA T KUBO M TOHYAMA T MATSUNAGA CHANGES IN PREPROENKEPHALIN MESSENGER-RNA AFTER UNILATERAL AND BILATERAL LABYRINTHECTOMY IN THE RAT MEDIAL VESTIBULAR NUCLEUS MOLECULAR BRAIN RESEARCH 0169-328X 19 3 237 240 19930800 10.1016/0169-328X(93)90034-M read0013690/published_papers/15122987 Arata Horii Noriaki Takeda Masahiro Morita Takeshi Kubo T Matsunaga Motion sickness induced by sinusoidal linear acceleration in rats Acta Oto-Laryngologica. Supplementum. 0365-5237 501 31 33 19930000 read0013690/published_papers/15122986 I Koizuka Noriaki Takeda S Sato Takeshi Kubo T Matsunaga Nystagmus responses in normal subjects during eccentric sinusoidal rotation Acta Oto-Laryngologica. Supplementum. 0365-5237 501 34 37 19930000 read0013690/published_papers/15122985 Noriaki Takeda 武田 憲昭 呼吸上皮知覚神経系:免疫組織化学法，in situ ハイブリダイゼーション法 日本鼻科学会会誌 13 351 353 19930000 read0013690/published_papers/15122984 大野 浩司 Noriaki Takeda 武田 憲昭 久保 武 松永 亨 木山 博資 遠山 正弥 前庭遠心系における神経伝達物質について 頭頚部自律神経 7 4 5 19930000 read0013690/published_papers/15122892 Noriaki Takeda 武田 憲昭 芦田 健太郎 田矢 直三 肥塚 泉 阪上 雅史 土井 勝美 荻野 仁 松永 亨 前庭型メニエール病と内リンパ水腫 Equilibrium Research 0385-5716 52 175 180 19930000 10.3757/jser.52.332 read0013690/published_papers/15122891 Noriaki Takeda 武田 憲昭 佐藤 信次 肥塚 泉 林 治博 荻野 仁 松永 亨 前庭機能の加齢変化 The effects of age on vestibular functions was examined with comparative vestibular testings in young and elderly volunteers. In rotational test with pseudorandom acceleration, the gain in the vestibulo-ocular reflex (VOR) at 0.6, 0.8, 1.0 Hz in the elderly subjects was not different from that in the young subjects. The elementary mechanisms of VOR seem to be preserved with aging. However, perception of velocity change was markedly impaired in the elderly people during pseudorandom rotation in the dark. Central dysfunction processing the vestibular information to provide self-motion perception was suggested in the elderly people. When subjects were rotated sinusoidally at 0.64 Hz and asked to fixate stationary imaginary target in the dark, the gain of VOR was increased. The gain enhancement of VOR in the elderly people was less than that in the young people. It is suggested that adaptive control system of VOR that depend on selecting orienting strategies is impaired by aging. The central vestibular system dysfunction seems to primarily contribute to disequilibrium in the elderly. 加齢にともなう平衡機能の変化を調べる目的で, まず回転検査による前庭-動眼反射の利得を高齢者群と若年者群で比較したが差は認められなかつた. 次に, pseudorandom acceleration回転刺激中の回転速度の変化の認知率を検討したところ, 高齢者群では著明に低下していた. さらに, 中心性および偏中心性回転刺激において被検者に暗算を負荷した場合と地上の想定指標を固視するように指示した場合で前庭-動眼反射の利得を比較した. その結果, 指標を想定することによる前庭-動眼反射の利得の増加は高齢者群で劣つていた. 以上の結果から加齢による反射レベルの機能低下はほとんど認められず, 高齢者の平衡障害は高次中枢における前庭情報の求心性処理機能の低下や, 高次中枢が空間認知に基づいて前庭-動眼反射を調節する遠心性制御機構の異常に基づくものと推定した. JIBI TO RINSHO KAI 耳鼻と臨床会 Otologia Fukuoka 耳鼻と臨床 0447-7227 39 5 750 756 19930000 10.11334/jibi1954.39.5Supplement2_750 read0013690/published_papers/15122890 Noriaki Takeda 武田 憲昭 長谷川 哲 松永 亨 「トラベルミンSR錠」のラットの動揺病に対する抑制効果 the Clinical Report 基礎と臨床 27 3175 3180 19930000 read0013690/published_papers/15122893 S Hasegawa Noriaki Takeda M Morita A Horii I Koizuka Takeshi Kubo Toru Matsunaga Vestibular, central and gastral triggering of emesis Using kaolin intake as a behavioral index of emesis in rats, we examined the relationship between susceptibility to motion sickness and to emesis induced by apomorphine or copper sulfate. Rats showed a wide variation in susceptibility to motion sickness. Significant positive correlations were found between susceptibility to motion sickness and to emesis induced by intraperitoneal administration of apomorphine and by oral administration of copper sulfate. Motion, apomorphine and copper sulfate induce emesis through different receptors, so these findings suggest that the sensitivity of a common locus of emesis, presumably the emetic center in the brain stem, is one determinant of individual differences in susceptibility to motion sickness. Acta Oto-Laryngologica 0001-6489 112 6 927 931 19921100 1481662 read0013690/published_papers/15122899 Y ABE N TAKEDA M IRIFUNE S OGINO B KALUBI IMAMURA, I H FUKUI H WADA T MATSUNAGA EFFECTS OF CAPSAICIN DESENSITIZATION ON NASAL ALLERGY-LIKE SYMPTOMS AND HISTAMINE-RELEASE IN THE NOSE INDUCED BY TOLUENE DIISOCYANATE IN GUINEA-PIGS ACTA OTO-LARYNGOLOGICA 0001-6489 112 4 703 709 19920700 1279933 read0013690/published_papers/15122898 Y ABE N TAKEDA M IRIFUNE S OGINO B KALUBI IMAMURA, I H FUKUI H WADA T MATSUNAGA EFFECTS OF CAPSAICIN DESENSITIZATION ON NASAL ALLERGY-LIKE SYMPTOMS AND HISTAMINE-RELEASE IN THE NOSE INDUCED BY TOLUENE DIISOCYANATE IN GUINEA-PIGS ACTA OTO-LARYNGOLOGICA 0001-6489 112 4 703 709 19920700 read0013690/published_papers/15122895 M IGARASHI N TAKEDA S CHAE UVULA-NODULUS AND GRAVITY DIRECTION (A STUDY ON VERTICAL OPTOKINETIC-OCULOMOTOR FUNCTIONS) ACTA ASTRONAUTICA 0094-5765 27 25 30 19920700 10.1016/0094-5765(92)90170-N 11537592 read0013690/published_papers/15122896 JB LUCOT James B. Lucot N TAKEDA Noriaki Takeda ALPHA-FLUOROMETHYLHISTIDINE BUT NOT DIPHENHYDRAMINE PREVENTS MOTION-INDUCED EMESIS IN THE CAT α-fluoromethylhistidine but not diphenhydramine prevents motion-induced emesis in the cat AMERICAN JOURNAL OF OTOLARYNGOLOGY American Journal of Otolaryngology 0196-0709 13 3 176 180 19920500 10.1016/0196-0709(92)90119-E 1626619 read0013690/published_papers/15122897 B KALUBI N TAKEDA M IRIFUNE S OGINO Y ABE SL HONG M YAMANO T MATSUNAGA M TOHYAMA NASAL-MUCOSA SENSITIZATION WITH TOLUENE DIISOCYANATE (TDI) INCREASES PREPROTACHYKININ-A (PPTA) AND PREPROCGRP MESSENGER-RNAS IN GUINEA-PIG TRIGEMINAL GANGLION NEURONS BRAIN RESEARCH 0006-8993 576 2 287 296 19920400 10.1016/0006-8993(92)90692-3 read0013690/published_papers/15122998 Noriaki Takeda S Hasegawa Masahiro Morita Arata Horii Takeshi Kubo T Matsunaga Pharmacology of motion-induced emesis of rats Proceedings of XVII Barany Society Meeting 281 283 19920000 read0013690/published_papers/15122997 K Ohino Noriaki Takeda H Kiyama Takeshi Kubo M Tohyama T Matsunaga Cholinergic innervation in the rat vestibular end-organs Proceedings of XVII Barany Society Meeting 194 1958 19920000 read0013690/published_papers/15122996 T Saika Noriaki Takeda H Kiyama Takeshi Kubo M Tohyama T Matsunaga Changes in gene-expression of neuropeptides after unilateral labyrinthectomy in the rat brain stem Proceedings of XVII Barany Society Meeting 196 197 19920000 read0013690/published_papers/15122995 Arata Horii Noriaki Takeda T Matsunaga Atsushi Yamatodani T Mochizuki K Okakura H Wada Effect of caloric stimulation of histaminergic neuron system of rats Proceedings of XVII Barany Society Meeting 167 168 19920000 read0013690/published_papers/15122994 Noriaki Takeda S Hasegawa Masahiro Morita Arata Horii T Matsunaga Effects of anti-emetics on motion sickness of rats Proceedings of the 3rd International Symposium on Space Medicine in Nagoya 1992 187 193 19920000 read0013690/published_papers/15122993 K Ohino Noriaki Takeda H Kiyama Takeshi Kubo M Tohyama T Matsunaga Acetylcholine in the rat vestibular efferent system Proceedings of Sendai Symposium 17 19 19920000 read0013690/published_papers/15122992 M Sakagami M Umemoto K Kitamura Noriaki Takeda T Matsunaga T Kasugai Y Kitamura Inner ear function and Morphology of a Ws/Ws rat Journal of Clinical Electron Microscopy 25 5 6 19920000 read0013690/published_papers/15122991 川嵜 良明 Noriaki Takeda 武田 憲昭 肥塚 泉 荻野 仁 松永 亨 めまい患者の自律神経機能: R-R 間隔の周波数分析を用いた検討 頭頚部自律神経 6 21 25 19920000 read0013690/published_papers/15122990 落合 薫 Noriaki Takeda 武田 憲昭 肥塚 泉 松永 亨 荻野 仁 メニエール病患者の自律神経機能動態について 頭頚部自律神経 6 26 28 19920000 read0013690/published_papers/15122989 北村 健 梅本 匡則 阪上 雅史 Noriaki Takeda 武田 憲昭 松永 亨 春日井 務 北村 幸彦 メラノサイト欠損ラットにおける聴覚機能 Audiology Japan 0303-8106 35 405 406 19920000 10.4295/audiology.35.405 read0013690/published_papers/15122988 松永 亨 Noriaki Takeda 武田 憲昭 めまい:メニエール症候群 Popular Medicine からだの科学 0453-3038 166 22 28 19920000 read0013690/published_papers/15122894 Kayoko Bessho 別所 佳代子 Satoshi Ogino 武田 憲昭 Noriaki Takeda 荻野 敏 Tamotsu Harada 原田 保 Toru Matsunaga 入船 盛弘 Hitoshi Ogino 松永 亨 Morihiro Irifune Relationship between Ménière's Disease and Type I Allergy Tested by MAST System. メニエール病におけるI型アレルギーの関与 Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 85 9 1375 1381 19920000 10.5631/jibirin.85.1375 2-s2.0-85009535679 read0013690/published_papers/15122900 K OHNO N TAKEDA M YAMANO T MATSUNAGA M TOHYAMA COEXISTENCE OF ACETYLCHOLINE AND CALCITONIN GENE-RELATED PEPTIDE IN THE VESTIBULAR EFFERENT NEURONS IN THE RAT BRAIN RESEARCH 0006-8993 566 1-2 103 107 19911200 10.1016/0006-8993(91)91686-U read0013690/published_papers/15123005 Noriaki Takeda M Igarashi I Koizuka SY Chae T Matsunaga Effects of otolith stimulation in eccentric rotation on the vestibulo-ocular reflex in squirrel monkeys Acta Oto-Laryngologica. Supplementum. 0365-5237 481 27 30 19910000 read0013690/published_papers/15123004 I Koizuka Noriaki Takeda S Sato M Sakagami T Matsunaga Centric and eccentric VOR tests in patients with Meniere's disease and vestibular Meniere's disease Acta Oto-Laryngologica. Supplementum. 0365-5237 481 55 58 19910000 read0013690/published_papers/15123003 Noriaki Takeda Pharmacology of motion and space sickness Proceedings of International Conference on the Vestibular Nervous System in Space 39 43 19910000 read0013690/published_papers/15123002 田矢 直三 尾崎 康弘 荻野 仁 Noriaki Takeda 武田 憲昭 肥塚 泉 後藤 和彦 松永 亨 ストレス負荷時の椎骨動脈，総頚動脈血流の変化 頭頚部自律神経 5 16 17 19910000 read0013690/published_papers/15123001 落合 薫 Noriaki Takeda 武田 憲昭 肥塚 泉 荻野 仁 松永 亨 メニエール病患者の自律神経機能について:サーモグラフィーを用いて 頭頚部自律神経 5 14 15 19910000 read0013690/published_papers/15123000 芦田 健太郎 Noriaki Takeda 武田 憲昭 肥塚 泉 坂上 雅史 荻野 仁 松永 亨 前庭型メニエール病の蝸電図検査 Clinical vestibular and auditory studies were done on 17 patients with vestibular Meniere's disease characterized by recurrent episodes of vertigo. According to the duration of the vertigo attack, the subjects were dividided into two groups. Four of eight patients in the group with long duration of vertigo (more than 10 minutes) showed fluctuating hearing loss in the lower frequency ranges and later develo ped typical Meniere's disease. All of them exhibited canal paresis and three of them have predominance of -SP in the affected ear. We concluded that in patients with vestibular Meniere's disease with long vertigo attacks and predominance of -SP and canal paresis, vestibular symptoms would probably be followed by the development of typical Meniere's disease. Japan Society for Equilibrium Research Equilibrium Research. Supplement 0385-5716 7 7 43 454 19910000 10.3757/jser.50.Suppl-7_43 read0013690/published_papers/15122999 松永 亨 Noriaki Takeda 武田 憲昭 Meniere病 Internal Medicine 臨床雑誌 内科 0022-1961 68 454 458 19910000 read0013690/published_papers/15122901 川嵜 良明 Noriaki Takeda 武田 憲昭 肥塚 泉 荻野 仁 松永 亨 めまい患者の自律神経機能 Otologia Fukuoka 耳鼻と臨床 0447-7227 37 1266 1273 19910000 10.11334/jibi1954.37.5Supplement6_1266 read0013690/published_papers/15122902 Noriaki Takeda Masahiro Morita A Yamatodani Hiroshi Wada Toru Matsunaga Catecholaminergic responses to rotational stress in rat brain stem Aviation, Space, and Environmental Medicine 61 11 1018 1021 19901100 read0013690/published_papers/15122903 M MORITA N TAKEDA S HASEGAWA A YAMATODANI H WADA SI SAKAI T KUBO T MATSUNAGA EFFECTS OF ANTICHOLINERGIC AND CHOLINERGIC DRUGS ON HABITUATION TO MOTION IN RATS ACTA OTO-LARYNGOLOGICA 0001-6489 110 3-4 196 202 19900900 read0013690/published_papers/15122905 N TAKEDA M IGARASHI KOIZUKA, I SY CHAE T MATSUNAGA RECOVERY OF THE OTOLITH-OCULAR REFLEX AFTER UNILATERAL DEAFFERENTATION OF THE OTOLITH ORGANS IN SQUIRREL-MONKEYS ACTA OTO-LARYNGOLOGICA 0001-6489 110 1-2 25 30 19900700 read0013690/published_papers/15122906 T Himi M Igarashi Noriaki Takeda Effect of vestibulo-cerebellar lesions on asymmetry of vertical optokinetic functions in the squirrel monkey Acta Oto-Laryngologica 0001-6489 109 3-4 188 194 19900500 read0013690/published_papers/15123007 肥塚 泉 Noriaki Takeda 武田 憲昭 佐藤 信次 坂上 雅史 松永 亨 Centric, Eccentric VOR からみたメニエール病の評価:特に前庭型メニエール病 Pendular rotation in the eccentric position produces the same angular stimulation as conventional pendular rotation (i. e., centric rotation) ; moreover, it involves linear centrifugal and tangential acceleration forces which act on the otolith organs. In the eccentric position, normal subjects showed a greater gain of slow phase eye movements at 0.64 Hz, than when the head was in the centric position. We conclude that it is possible to diagnose otolith dysfunction by these comparison. In this study, we applied centric and eccentric pendular rotation tests to eleven patients with Meniere's disease and seven patients with vestibular Meniere's disease to investigate their otolith function. With in one month after their first attack or after a recent attack, no gain enhancement with eccentric rotation was noted in either group. Others showed normal gain enhancement in the eccentric rotation test. We conclude that there is no difference in otolith function in patients with Meniere's disease and those with vestibular Meniere's disease. Japan Society for Equilibrium Research Equilibrium Research. Supplement 0385-5716 6 6 77 81 19900000 10.3757/jser.49.Suppl-6_77 read0013690/published_papers/15123006 落合 薫 Noriaki Takeda 武田 憲昭 肥塚 泉 荻野 仁 松永 亨 メニエール病患者の自律神経機能について(サーモグラフィーを用いて) 頭頚部自律神経 4 38 40 19900000 read0013690/published_papers/15122909 M Igarashi S Chae S MacDonald T Himi Noriaki Takeda Autonomic indexes during the vestibular-visual conflict exposure: a squirrel monkey study Auris Nasus Larynx 17 2 69 76 19900000 read0013690/published_papers/15122908 荻野 仁 肥塚 泉 Noriaki Takeda 武田 憲昭 松永 亨 めまい患者に対する抗不安薬 etizolam の有効性 The effect of etizolam, a thienodiazepine, was compared with that of a placebo in a double-blind controlled study of patients with vertigo.<BR>1) The final global improvement rate in the etizolam group was moderate to excellent in 52.4%, and slight to excellent in 81.0%.<BR>The final global improvement rate in the placebo group was excellent in 18.8% and slight to excellent in 56.3%, and worsening of vertigo occurred in 12.5 % of the placebo group. The difference between the two groups are significant.<BR>2) Etizolam was significantly more effective than placebo in treating patients with anxiety.<BR>3) Etizolam was significantly more effective than placebo for non-rotatory vertigo in the first and second weeks of treatment.<BR>4) Side-effects were observed in 12.5% of the etizolam group and in 25.0% of the placebo group, not a significant difference. None of the side-effects were severe.<BR>5) The global utility rate of etizolam was significantly greater than that of placebo. Japan Society for Equilibrium Research Equilibrium Research 0385-5716 49 3 301 311 19900000 10.3757/jser.49.301 read0013690/published_papers/15122907 M TANAKA N TAKEDA M TOHYAMA T MATSUNAGA IMMUNOCYTOCHEMICAL LOCALIZATION OF MITOCHONDRIAL AND CYTOSOLIC ASPARTATE-AMINOTRANSFERASE ISOZYMES IN THE VESTIBULAR END-ORGANS OF RATS EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY 0937-4477 247 2 119 121 19900000 read0013690/published_papers/15122904 M IGARASHI T HIMI S MACDONALD N TAKEDA A KATAURA THE EFFECT OF SACCULAR ABLATION ON VERTICAL OPTOKINETIC AFTER-NYSTAGMUS IN SQUIRREL-MONKEYS EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY 0937-4477 247 5 274 276 19900000 10.1007/BF00176535 read0013690/published_papers/15122910 M TANAKA N TAKEDA E SENBA M TOHYAMA T KUBO T MATSUNAGA LOCALIZATION, ORIGIN AND FINE-STRUCTURE OF CALCITONIN GENE-RELATED PEPTIDE-CONTAINING FIBERS IN THE VESTIBULAR END-ORGANS OF THE RAT BRAIN RESEARCH 0006-8993 504 1 31 35 19891200 10.1016/0006-8993(89)91593-X read0013690/published_papers/15123015 M Tanaka Noriaki Takeda E Senba M Tohyama Takeshi Kubo T Matsunaga ocalization and origins of calcitonin gene-related peptide containing fibres in the vestibular end-organs of the rat Acta Oto-Laryngologica. Supplementum. 0365-5237 468 31 34 19890000 read0013690/published_papers/15123014 Noriaki Takeda 武田 憲昭 病態との関与:鼻過敏症と神経ペプチド The Journal of Japan Rhinologic Society 日本鼻科学会会誌 27 311 320 19890000 read0013690/published_papers/15123013 肥塚 泉 佐藤 信次 Noriaki Takeda 武田 憲昭 荻野 仁 久保 武 松永 亨 Centric, Eccentric VOR 検査による前庭機能異常患者の評価 Harmonic acceleration tests in the yaw plane with the head centered or in an eccentric position 90cm from the axis of rotation were performed in 41 patients with unilateral canal paresis due to vestibular neuronitis and sudden deafness, Meniere's disease and benign paroxysmal positional vertigo (BPPV). In the eccentric VOR at 0.32 and 0.6Hz, gain enhancement and phase lead were observed in the normal subjects. In the eccentric VOR, subjects were stimulated both by angular acceleration, as well as linear centrifugal and tangential acceleration, which act on the otolith organs. At 0.32 and 0.64Hz in this position, tangential acceleration showed a higher value than centrifugal acceleration. Therefore, we concluded that the gain enhancement and phase lead in the eccentric VOR were derived from tangential acceleration acting on the utriculus.<BR>The patients with vestibular disorders other than BPPV showed normal gain enhancement and phase lead at 0.32 and 0.64Hz. However, patients with BPPV, showed no gain enhancement or phase lead in 53.3% and 73.3% of the patients, respectively.<BR>It is suggested that BPPV results from incorrect response of the cupola in the posterior semicircular canal to gravitational changes due to otolithiasis. Therefore, the loss of gain enhancement and phase lead in the eccentric VOR in the patients with BPPV may be the result of utricular dysfunction. Japan Society for Equilibrium Research Equilibrium Research. Supplement 0385-5716 5 5 143 146 19890000 10.3757/jser.48.5Supplement_143 read0013690/published_papers/15123012 荻野 仁 肥塚 泉 Noriaki Takeda 武田 憲昭 佐藤 光弘 松永 亨 メニエール病の長期の聴力変化について Long-term hearing changes were investigated in 63 patients with Meniere's disease (46 unilateral, 17 bilateral). In most patients with unilateral Meniere's disease, the hearing level noted on the initial visit remained unchanged for a long time. In young patients who had therapy at an early stage, hearing was improved or conserved at a good level. On the other hand, in most patients with bilateral disease, hearing on the initial visit was worse than in those with unilateral disease, and it became gradually worse. Those with late onset often had very poor hearing and early therapy was not possible. Hearing changes in unilateral and bilateral Meniere's disease appear to have different mechanism. Japan Society for Equilibrium Research Equilibrium Research. Supplement 0385-5716 5 5 26 33 19890000 10.3757/jser.48.5Supplement_26 read0013690/published_papers/15123011 田矢 直三 尾崎 康弘 後藤 和彦 佐野 光弘 肥塚 泉 Noriaki Takeda 武田 憲昭 荻野 仁 松永 亨 超音波ドップラー血流計を用いた循環改善剤の評価について 1. We evaluated the effects of ATP (adenosine triphosphate), dilazep dihydrochloride and vinpocetine by testing vertebral arterial blood flow with the ultrasonic doppler method. Each drug was administrered orally to patients with vertigo or dizziness for 4 to 8 weeks.<BR>2. The rate of clinical efficacy of ATP was 88.9%, that of dilazep dihydrochloride was 87.5%, and that of vinpocetine was 73.7%. No adverse reaction was observed.<BR>3. In the patients who received vinpocentine, there was a significant increase of vertebral arterial blood flow and a significant decrease of the right left difference in that flow.<BR>4. In 10 patients whose vertebral arterial blood flow before administration was normal, the clinical efficacy rate was high, 100% and 78.3% in the decreased blood flow group, and 78.3% in the right-left difference blood flow group.<BR>5. In the patients with abnormal vertebral arterial blood flow before treatment and after with normal flow, after treatment, the rate of efficacy was higher than in the patients with abnormal flow after treatment.<BR>6. Administering ATP and dilazep dihydrochloride together had a good clinical effect and improved vertebral arterial blood flow. Japan Society for Equilibrium Research Equilibrium Research. Supplement 0385-5716 5 5 120 125 19890000 10.3757/jser.48.5Supplement_120 read0013690/published_papers/15123010 田中 美由起 Noriaki Takeda 武田 憲昭 久保 武 松永 亨 仙波 恵美子 遠山 正弥 ラット前庭末梢 CGRP 含有神経線維の電子顕微鏡的観察 In this immunoelectromicroscopic analysis, calcitonin gene-related peptide (CGRP) -like immunoreactive (CGRPI) fibers were identified to make the synaptic contact with the nerve chalices which surround the type I cells in the vestibular end-organs. But no synaptic contact between CGRPI fibers and type II cells was found. Therefore, it is suggersted that CGRP containing efferent fibers are involved in the regulation of the transmission of the vestibular information from the type I cells. THE JAPAN OTOLOGICAL SOCIETY Ear Research Japan 0288-9781 20 1 105 106 19890000 10.11289/otoljpn1981.20.105 read0013690/published_papers/15123009 守田 雅弘 Noriaki Takeda 武田 憲昭 長谷川 哲 酒井 俊一 久保 武 松永 亨 動揺病の発症要因としての加速度刺激の意義 頭頚部自律神経 3 51 54 19890000 read0013690/published_papers/15123008 カルビ ブカサ 田中 美由起 Noriaki Takeda 武田 憲昭 入船 盛弘 荻野 敏 塩坂 貞夫 遠山 正弥 松永 亨 上気道粘膜における neuropeptide の分布について 頭頚部自律神経 3 4 5 19890000 read0013690/published_papers/15122911 肥塚 泉 島田 久美 Noriaki Takeda 武田 憲昭 荻野 仁 浅井 英世 久保 武 松永 亨 内耳局所水分代謝異常が原因と思われたレルモワイエ症候群の1症例 A 62-year-old female presented with vertigo, tinnitus, sensation of fullness and fluctuating hearing loss of sensorineural type on the left ear. Thirteen years after, the vestibular symptoms disappeared naturally, but the cochlear symptoms are still present. Dehydration therapy, such as the oral administration of iso-sorbid or the intra-venous injection of furosemide aggravated the cochlear symptoms while overhydration therapy improved them. The results of the dehydration and hydration tests evaluated by hearing level were opposite to those frequently observed in patients with endolymphatic hydrops.Therefore, we assume that occlusion of the reuniens duct or utriculo-endolymphatic valve and endolymphatic collapse in the cochlea were responsible for the characteristic course of the symptoms in our patient. Japan Society for Equilibrium Research Equilibrium Research 0385-5716 49 2 216 221 19890000 10.3757/jser.49.216 read0013690/published_papers/15122915 M MORITA N TAKEDA T KUBO A YAMATODANI H WADA T MATSUNAGA EFFECTS OF ANTI-MOTION SICKNESS DRUGS ON MOTION SICKNESS IN RATS ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES 0301-1569 50 5 330 333 19880900 read0013690/published_papers/15122912 M TANAKA N TAKEDA E SENBA M TOHYAMA T KUBO T MATSUNAGA LOCALIZATION OF CALCITONIN GENE-RELATED PEPTIDE IN THE VESTIBULAR END-ORGANS IN THE RAT - AN IMMUNOHISTOCHEMICAL STUDY BRAIN RESEARCH 0006-8993 447 1 175 177 19880400 10.1016/0006-8993(88)90981-X read0013690/published_papers/15123022 Noriaki Takeda M Morita Takeshi Kubo Atsushi Yamatodani H Wada T Matsunaga Is the noradrenergic neuron system in the brain stem related to motion sickness in rats Advances in Oto-Rhino-Laryngology 42 234 237 19880000 read0013690/published_papers/15123021 I Koizuka Noriaki Takeda Takeshi Kubo T Matsunaga Effects of deuterium oxide and ethyl alcohol on vestibulo-ocular reflex in rabbits Advances in Oto-Rhino-Laryngology 42 238 241 19880000 read0013690/published_papers/15123020 肥塚 泉 Noriaki Takeda 武田 憲昭 荻野 仁 久保 武 松永 亨 総合的平衡機能検査装置(MVM-C2)による Centric 及び Eccentric VOR 検査 Harmonic acceleration tests in yaw plane were performed in 14 normal subjects, with the head centered or in an eccentric position 90 cm from the axis of rotation in an investigation of the influence of additional linear acceleration on the canal-ocular reflex. Pendular rotation in the eccentric position produces the same angular stimulation and, in addition, involves linear centrifugal and tangential acceleration vectors which act on the otolith organs. In the eccentric position, all subjects showed an in crease in gain of slow phase eye movements at 0.32 Hz and 0.64 Hz, when compared with the results in the head centered position. For the high frequency range in eccentric pendular rotation, the value of tangential acceleration was larger than that of centrifugal acceleration. In the eccentric position, tangential acceleration is sensed mainly by the utriculus. Therefore it appeares that gain enhancement at high frequencies in eccentric pendular rotation is derived from tangential acceleration acting on the utriculus. Japan Society for Equilibrium Research Equilibrium Research. Supplement 0385-5716 4 4 63 67 19880000 10.3757/jser.47.Suppl-4_63 read0013690/published_papers/15123019 落合 薫 Noriaki Takeda 武田 憲昭 荻野 仁 松永 亨 メニエール病患者の自律神経機能について We analyzed the bilateral oculo-cardiac reflex in patients with Meniere's disease and evaluated their parasympathetic nervous function. Although the oculo-cardiac responses of patients with Meniere's disease were not different from those of healthy controls, the incidence of difference in laterality of each eye response was significantly increased in the patients. In addition, the patients with Meniere's disease exhibited weaker oculo-cardiac responses of the affec-ted side than on the unaffected side. These findings suggest asymmetry of parasympathetic nervous function in patients with Meniere's disease. Japan Society for Equilibrium Research Equilibrium Research. Supplement 0385-5716 4 4 84 87 19880000 10.3757/jser.47.Suppl-4_84 read0013690/published_papers/15123018 山本 好一 Noriaki Takeda 武田 憲昭 久保 武 松永 亨 メニエール病患者の自律神経機能6-ハイドロキシドーパミン及びアンフェタミン投与時の家兎圧受容器反射感度について The effects of 6-hydroxydopamine (6-OHDA) and amphetamine on baroreflex sensitivity (BRS), blood pressure (BP) and brain stem PO2 tension were studied in conscious rabbits. 6-OHDA, which produces chronic degeneration of catecholamine (CA) nerve terminals was injected into a lateral ventricle of the brain. The facilitation of CNS CA release was produced by intravenous injection of amphetamine.BRS was calculated from changes in the BP after the injection of norepinephrine (NE) or nitroglycerine. Following 6-OHDA administration, BRS became significantly higher and BP fluctuation was minimum for one hour in loosely restrained rabbits. On the other hand, amphetamine inhibited the BRS and caused large fluctuations of BP, as has been shown in other reports. Furthermore, decreases of BP and brain stem PO2 were observed when passive head up tilt (45 degrees) was performed quickly in rabbits with lower BRS.<BR>These findings suggest that brain stem blood flow is hampered by disturbances of BRS caused by prolonged exposure to stressfull conditions. Japan Society for Equilibrium Research Equilibrium Research. Supplement 0385-5716 4 4 45 50 19880000 10.3757/jser.47.Suppl-4_45 read0013690/published_papers/15123017 神畠 俊子 守田 雅弘 Noriaki Takeda 武田 憲昭 荻野 仁 松永 亨 めまい患者の血小板機能 Equilibrium Research. Supplement 4 91 93 19880000 10.3757/jser.47.Suppl-4_91 read0013690/published_papers/15123016 田中 美由起 Noriaki Takeda 武田 憲昭 松永 亨 仙波 恵美子 遠山 正弥 ラット前庭におけるCGRP含有神経線維の分布 The present immunocytochemical study has demonstrated the presence of a dense fiber plexus containing calcitonin gene-related peptide (CGRP) in the vestibular end-organs in the rats. These fibers appear to originate from the central nervous system. And it was suggested that the possibility that CGRP acts as a vestibular efferent neurotransmitter. THE JAPAN OTOLOGICAL SOCIETY Ear Research Japan 0288-9781 19 28 29 19880000 10.11289/otoljpn1981.19.28 read0013690/published_papers/15122916 M Morita Noriaki Takeda T Kubo T Matsunaga Pica as an index of motion sickness of rats ORL; Journal for Oto-Rhino-Laryngology and Its Related Specialties 50 3 188 192 19880000 read0013690/published_papers/15122914 I Koizuka Noriaki Takeda T Kubo T Matsunaga CI Cha Effects of ethyl alcohol and heavy-water administration on vestibulo-ocular reflex in rabbits ORL; Journal for Oto-Rhino-Laryngology and Its Related Specialties 51 3 151 155 19880000 read0013690/published_papers/15122913 Noriaki Takeda 武田 憲昭 荻野 仁 浅井 英世 森山 篤 松永 亨 水分代謝障害を背景に持つと思われたレルモワイエ症候群の1症例 A 52-year-old female had recurrent episodes of tinnitus, hearing less and vertigo. When systemic edema accompanied the vertigo attack, tinnitus and hearing less disappeared--the characteristic course of Lermoyez's syndrome.<BR>Overhydration with drinking water could induce systemic edema, nystagmus and improvement of hearing, while dehydration with furosemide caused the impatred hearing and disapparance of edema and nystagmus. The results of the hydration and dehydration tests were directly opposite to those in patients with Meniere's disease, in which the etiology is endolymphatic hydrops. Therefore, we concluded that endolymphatic collapse was responsible for the characteristic course of the symptoms in our patient. The same mechanism of water metabolism is probably the cause of both Lermoyez's syndrome and idiopathic edema. Japan Society for Equilibrium Research Equilibrium Research 0385-5716 47 3 365 370 19880000 10.3757/jser.47.365 read0013690/published_papers/15122917 N TAKEDA K DOI N MORI H YAMAZAKI M TOHYAMA T MATSUNAGA LOCALIZATION AND FINE-STRUCTURE OF CALCITONIN GENE-RELATED PEPTIDE (CGRP)-LIKE IMMUNOREACTIVE NERVE-FIBERS IN THE ORGAN OF CORTI OF GUINEA-PIGS BY IMMUNOHISTOCHEMISTRY ACTA OTO-LARYNGOLOGICA 0001-6489 103 5-6 567 571 19870500 read0013690/published_papers/15123026 Noriaki Takeda M Morita Takeshi Kubo Atsushi Yamatodani H Wada M Tohyama T Matsunaga Histaminergic projection from the posterior hypothalamus to the medial vestibular nucleus of rats and its relation to motion sickness The Vestibular System: Neurophysiological and Clinical Research 607 616 19870000 read0013690/published_papers/15123025 Noriaki Takeda M Morita Takeshi Kubo H Wada T Matsunaga Role of histamine in motion sickness and space motion sickness Biological Sciences in Space 173 177 19870000 read0013690/published_papers/15123024 肥塚 泉 Noriaki Takeda 武田 憲昭 荻野 仁 久保 武 松永 亨 総合的平衡機能検査装置(MVM-C2)による前庭機能異常患者の評価 Over the past several years, quantitative analysis for quantifying voluntary and involuntary eye movements has developed, accompanied with the advancement of computer technology. In our laboratory, we introduced computer aided test equipment for evaluating the vestibular function of patients with vestibular disorder. In this paper, we showed specification of this new machine and we indicated results of centric and eccentric VOR test and that of pseudo random binary sequence. Japan Society for Equilibrium Research Equilibrium Research. Supplement 0385-5716 2 2 92 98 19870000 10.3757/jser.46.Suppl-2_92 read0013690/published_papers/15123023 田中 美由起 Noriaki Takeda 武田 憲昭 松永 亨 仙波 恵美子 遠山 正弥 和田 博 ラット聴覚前庭系における活性物質の分布 The distribution of cholin acethyltranseferase-like immunoreactivities (CATI) and glutamic oxaloacetic transaminase-like immunoreactivities (GOTI) were studied immunohistochemically in the auditory and vestibular system of rat brain. CATI neurons were iocated in the superior olivary nuclear complex, the medial vestibular nucleus and the prepositus hypoglossal nucleus. Both cytosolic (s-) and mitochondrial (m-) GOTI neurons and fibers were unevenly distributed in the all auditory and vestibular nuclei. However, the Iatelar vestibular nucleus contained only m-GOTI neurons. These findings suggested that acethylcholine and glutamate/aspartate play important roles in the central auditory and vestibular system. THE JAPAN OTOLOGICAL SOCIETY Ear Research Japan 0288-9781 18 94 95 19870000 10.11289/otoljpn1981.18.94 read0013690/published_papers/15122918 Noriaki Takeda M Morita T Kubo A Yamatodani T Watanabe H Wada T Matsunaga Histaminergic mechanism of motion sickness Acta Oto-Laryngologica 101 5-6 416 421 19860500 read0013690/published_papers/15122919 Noriaki Takeda M. Kitajiri S. Girgis C. J. Hillyard I. MacIntyre P. C. Emson S. Shiosaka M. Tohyama T. Matsunaga The presence of a calcitonin gene-related peptide in the olivocochlear bundle in rat Experimental Brain Research 61 3 1432 1106 19860200 read0013690/published_papers/15123028 岡田 益明 Noriaki Takeda 武田 憲昭 松永 亨 大和谷 厚 和田 博 めまい患者における起立負荷試験と血中カテコラミンの関係 頭頚部自律神経 1 18 20 19860000 read0013690/published_papers/15123027 北尻 雅則 山下 敏夫 遠山 裕司 熊沢 忠躬 Noriaki Takeda 武田 憲昭 松永 亨 遠山 正弥 ラット内耳における calcitonin gene-related peptide (CGRP) 含有神経線維の分布について The localization and origins of calcitonin gene-related peptide-like immunoreactive (CGRPI) fibers in the rat cochlea were examined immunohistochemically. Numerous CGRPI fibers were found in the intraganglionic spiral bundle and inner spiral bundle. No CGRPI cells were seen in the organ of Corti and spiral ganglion.<BR>After parasagital transection of the brain just medial to the principle sensory trigeminal nucleus, CGRPI fibers in the cochlea disappeared ipsilaterally.<BR>From these results, CGRPI fibers in the cochlea seemed to be one of major components of the olivocochlear bundles originated from the superior olivary complex. THE JAPAN OTOLOGICAL SOCIETY Ear Research Japan 0288-9781 17 352 354 19860000 10.11289/otoljpn1981.17.352 read0013690/published_papers/15123029 T Watanabe Y Taguchi Noriaki Takeda S Shiosaka M Tohyama H Wada Purication of and antibodies against L-histidine decarboxylase Frontiers in Histamine Research - A Tribute to Heinz Schild (Hardcover) 91 102 19850601 read0013690/published_papers/15123031 Noriaki Takeda M Morita T Watanabe H Wada M Tohyama Takeshi Kubo T Matsunaga Histaminergic projection from the posterior hypothalamus to the medial vestibular nucleus in rats Sensory-motor Function under Weightlessness and Space Motion Sickness 91 98 19850000 read0013690/published_papers/15123030 Noriaki Takeda 武田 憲昭 北尻 雅則 川嵜 良明 遠山 正弥 松永 亨 ラット内耳における calcitonin gene-related peptide (CGRP) 含有神経線維の分布とその投射路 Audiology Japan 0303-8106 28 357 358 19850000 read0013690/published_papers/15122921 久保 武 奥村 新一 浅井 英世 守田 雅弘 Noriaki Takeda 武田 憲昭 白石 孝之 田中 美由起 松永 亨 突発性難聴に対する脱線維素原療法について Otologia Fukuoka 耳鼻と臨床 0447-7227 31 1231 1236 19850000 10.11334/jibi1954.31.6_1231 read0013690/published_papers/15122920 M KITAJIRI T YAMASHITA Y TOHYAMA T KUMAZAWA N TAKEDA Y KAWASAKI T MATSUNAGA S GIRGIS CJ HILLYARD MACINTYRE, I PC EMSON S SHIOSAKA M TOHYAMA LOCALIZATION OF CALCITONIN GENE-RELATED PEPTIDE IN THE ORGAN OF CORTI OF THE RAT - AN IMMUNOHISTOCHEMICAL STUDY BRAIN RESEARCH 0006-8993 358 1-2 394 397 19850000 10.1016/0006-8993(85)90992-8 read0013690/published_papers/15122924 Noriaki Takeda Atsushi Yamatodani Takehiko Watanabe Hiroshi Wada Effect of a new eburnamine derivative, RU 24722, on the turnover of monoamines in mouse brain European Journal of Pharmacology 0014-2999 106 2 357 362 19841113 10.1016/0014-2999(84)90723-4 read0013690/published_papers/15123032 岡田 益明 Noriaki Takeda 武田 憲昭 松永 亨 大和谷 厚 和田 博 Bell麻痺患者における交感神経機能 Facial Nerve Research Japan 0914-790X 4 117 120 19840000 read0013690/published_papers/15122926 阪上 雅史 荻野 仁 Noriaki Takeda 武田 憲昭 川崎 良明 松永 亨 後藤 和彦 古川 裕 興味ある経過を示した起立性低血圧症例:血圧と眼振の関係 Journal of Otolaryngology of Japa 日本耳鼻咽喉科学会会報 0030-6622 87 22 26 19840000 10.3950/jibiinkoka.87.22 read0013690/published_papers/15122925 H HAYASHI H TAKAGI N TAKEDA Y KUBOTA M TOHYAMA T WATANABE H WADA FINE-STRUCTURE OF HISTAMINERGIC NEURONS IN THE CAUDAL MAGNOCELLULAR NUCLEUS OF THE RAT AS DEMONSTRATED BY IMMUNOCYTOCHEMISTRY USING HISTIDINE-DECARBOXYLASE AS A MARKER JOURNAL OF COMPARATIVE NEUROLOGY 0021-9967 229 2 233 241 19840000 10.1002/cne.902290208 6094618 read0013690/published_papers/15122923 N TAKEDA S INAGAKI S SHIOSAKA Y TAGUCHI WH OERTEL M TOHYAMA T WATANABE H WADA IMMUNOHISTOCHEMICAL EVIDENCE FOR THE COEXISTENCE OF HISTIDINE DECARBOXYLASE-LIKE AND GLUTAMATE DECARBOXYLASE-LIKE IMMUNOREACTIVITIES IN NERVE-CELLS OF THE MAGNOCELLULAR NUCLEUS OF THE POSTERIOR HYPOTHALAMUS OF RATS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 0027-8424 81 23 7647 7650 19840000 10.1073/pnas.81.23.7647 read0013690/published_papers/15122922 N TAKEDA S INAGAKI Y TAGUCHI M TOHYAMA T WATANABE H WADA ORIGINS OF HISTAMINE-CONTAINING FIBERS IN THE CEREBRAL-CORTEX OF RATS STUDIED BY IMMUNOHISTOCHEMISTRY WITH HISTIDINE-DECARBOXYLASE AS A MARKER AND TRANSECTION BRAIN RESEARCH 0006-8993 323 1 55 63 19840000 10.1016/0006-8993(84)90264-6 read0013690/published_papers/15122927 Noriaki Takeda 武田 憲昭 久保 武 松永 亨 田中 悦子 真銅 昌二郎 ノルアドレナリンの血液粘稠度およびその規定因子におよぼす影響 Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 76 2304 2316 19830000 read0013690/published_papers/15122928 辻本 俊弥 玉置 弘光 石田 稔 Noriaki Takeda 武田 憲昭 松永 亨 宇田 弘次 耳下腺内リンパ節原発悪性リンパ腫:症例と文献的考察 Journal of Otolaryngology of Japa 日本耳鼻咽喉科学会会報 0030-6622 85 128 313 19820000 10.3950/jibiinkoka.85.128 read0013690/misc/11885383 Izumi Chida 千田 いづみ Noriaki Takeda 武田 憲昭 難聴を疑う 小児科 58 9 1063 1068 20170831 10.18888/sh.0000000147 read0013690/misc/11885384 Noriaki Takeda 武田 憲昭 めまいのリハビリテーション 耳石置換法と平衡訓練 Journal of Otolaryngology of Japa 日本耳鼻咽喉科学会会報 0030-6622 120 1 9 14 20170120 10.3950/jibiinkoka.120.9 read0013690/misc/11885386 Izumi Chida 千田 いづみ Noriaki Takeda 武田 憲昭 上・下気道症状を有するかぜの診断と治療 JOHNS 33 1 97 101 20170000 read0013690/misc/11885385 Aki Shimada 島田 亜紀 Jiro Udaka 宇高 二良 Noriaki Takeda 武田 憲昭 軽度中等度難聴児に対する補聴器購入費助成制度は? JOHNS 0910-6820 33 10 1479 1490 20170000 read0013690/misc/11885488 Noriaki Takeda 武田 憲昭 The 11^th Conference on Pediatric Otorhinolaryngology Japan 第11回日本小児耳鼻咽喉科学会 総会&bull;学術講演会 Padiatric Otorhinolaryngology Japan 小児耳鼻咽喉科 0919-5858 37 3 340 342 20160600 10.11374/shonijibi.37.340 read0013690/misc/11885388 Gou Satou 佐藤 豪 Noriaki Takeda 武田 憲昭 メニエール病 耳鼻咽喉科・頭頸部外科 88 5 238 241 20160430 read0013690/misc/11885387 近藤 昭男 Noriaki Takeda 武田 憲昭 ベーチェット病 耳鼻咽喉科・頭頸部外科 88 5 196 198 20160430 read0013690/misc/11885389 Noriaki Takeda 武田 憲昭 遅発性内リンパ水種 耳鼻咽喉科・頭頸部外科 88 3 248 251 20160320 read0013690/misc/11885390 Noriaki Takeda 武田 憲昭 前庭神経炎の診断と治療 一般社団法人 日本耳鼻咽喉科学会 日耳鼻専門医通信 0030-6622 119 3 119 220 20160000 10.3950/jibiinkoka.119.220 read0013690/misc/11885391 Noriaki Takeda 武田 憲昭 めまいの診断と治療 The Oto-Rhino-Laryngological Society of Japan, Inc. Journal of Otolaryngology of Japa 日本耳鼻咽喉科学会会報 0030-6622 118 11 1349 1351 20151100 10.3950/jibiinkoka.118.1348 read0013690/misc/11885392 Gou Satou 佐藤 豪 Noriaki Takeda 武田 憲昭 Meniere病 内科 114 6 1083 1086 20141200 read0013690/misc/11885393 Noriaki Takeda 武田 憲昭 神経耳科学の新展開 脳21 17 3 269 270 20140730 read0013690/misc/11885394 Takahiro Azuma 東 貴弘 Noriaki Takeda 武田 憲昭 顔面神経麻痺後後遺症評価法:その予防と治療 脳21 17 3 360 366 20140720 read0013690/misc/11885395 Noriaki Takeda 武田 憲昭 めまいの薬物治療 朝日新聞社 Medical ASAHI 0919-7818 43 7 37 39 20140700 read0013690/misc/11885398 Noriaki Takeda 武田 憲昭 メニエール病 ENT Compass 176 179 20140000 read0013690/misc/11885397 Noriaki Takeda 武田 憲昭 第32回日本耳鼻咽喉科免疫アレルギー学会 鼻アレルギーフロンティア 14 2 108 109 20140000 read0013690/misc/11885396 Noriaki Takeda 武田 憲昭 抗めまい薬のEBM ENTONI 162 1 4 20140100 read0013690/misc/11885399 Noriaki Takeda 武田 憲昭 難治性めまいへの対応 The Oto-Rhino-Laryngological Society of Japan, Inc. Journal of Otolaryngology of Japa 日本耳鼻咽喉科学会会報 0030-6622 116 4 1185 1191 20131100 10.3950/jibiinkoka.116.381 read0013690/misc/11885400 Noriaki Takeda 武田 憲昭 めまいの薬物治療 Pharma Medica 31 55 58 20131000 read0013690/misc/11885402 Noriaki Takeda 武田 憲昭 小児のめまい診断・治療の要点 ENTONI 158 71 75 20130900 read0013690/misc/11885401 Gou Satou 佐藤 豪 Noriaki Takeda 武田 憲昭 小児の脳血管障害によるめまい ENTONI 158 64 70 20130900 read0013690/misc/11885403 Takahiro Azuma 東 貴弘 Noriaki Takeda 武田 憲昭 口蓋扁桃摘出術に便利な手術装置を紹介してください ENT臨床フロンティア 口腔・咽頭疾患，歯牙関連疾患を診る 197 198 20130813 read0013690/misc/11885404 Noriaki Takeda 武田 憲昭 Kazunori Matsuda 松田 和徳 【メニエール病Update】 診療ガイドライン 耳鼻咽喉科・頭頸部外科 84 13 985 988 20121200 read0013690/misc/11885405 Noriaki Takeda 武田 憲昭 各めまい疾患の薬物治療 ENT臨床フロンティア めまいを見分ける・治療する 300 302 20121015 read0013690/misc/11885407 Noriaki Takeda 武田 憲昭 リハビリは有効か? ENT臨床フロンティア 急性難聴の鑑別とその対処 189 190 20120815 read0013690/misc/11885406 Noriaki Takeda 武田 憲昭 再発防止のための日常的アドバイス ENT臨床フロンティア 急性難聴の鑑別とその対処 191 192 20120815 read0013690/misc/11885408 Noriaki Takeda 武田 憲昭 Gou Satou 佐藤 豪 温度眼振検査 ENTONI 141 45 49 20120600 read0013690/misc/11885409 Noriaki Takeda 武田 憲昭 Gou Satou 佐藤 豪 めまい治療におけるステロイドと抗ウイルス薬の位置づけ ENTONI 139 39 43 20120400 read0013690/misc/11885410 Noriaki Takeda 武田 憲昭 Gou Satou 佐藤 豪 めまいとEBM JOHNS 0910-6820 28 2 167 171 20120200 read0013690/misc/11885414 小川 郁 北川 泰久 寺本 明 Noriaki Takeda 武田 憲昭 木村 健二郎 Multi-disciplinary Clinic for Vertigo and Dizziness 境界領域としてのめまい診療 日本医師会 The Journal of the Japan Medical Association 日本医師会雑誌 0021-4493 140 10 2049 2061 20120100 read0013690/misc/11885413 Yoshiaki Kitamura 北村 嘉章 Hiroyuki Mizuguchi 水口 博之 Hiroyuki Fukui 福井 裕行 Noriaki Takeda 武田 憲昭 初期療法はなぜ有効なのか? JOHNS 0910-6820 28 1 55 58 20120100 read0013690/misc/11885412 Yoshiaki Kitamura 北村 嘉章 Hiroyuki Mizuguchi 水口 博之 Hiroyuki Fukui 福井 裕行 Noriaki Takeda 武田 憲昭 Preseasonal prophylactic treatment with antihistamine on the expression of histamine H1 receptor and IL-5 in the nasal mucosa of patients with pollinosis ヒスタミンH1受容体遺伝子発現の亢進メカニズムと花粉症初期療法の分子機構 科学評論社 Clinical Immunology & Allergology 臨床免疫・アレルギー科 1881-1930 57 1 45 51 20120100 read0013690/misc/11885411 Gou Satou 佐藤 豪 Noriaki Takeda 武田 憲昭 良性発作性頭位めまい(BPPV) Clinical Neuroscience 0289-0585 30 1 68 73 20120101 read0013690/misc/11885415 高橋 美香 Noriaki Takeda 武田 憲昭 剣道 JOHNS 27 12 1939 1942 20111200 read0013690/misc/11885416 Yoshiaki Kitamura 北村 嘉章 Hiroyuki Mizuguchi 水口 博之 Hiroyuki Fukui 福井 裕行 Noriaki Takeda 武田 憲昭 スギ花粉症に対する初期療法 (特集 遺伝子解析からアレルギー疾患の治療戦略を考える) 金原出版 Pediatrics of Japan 小児科 0037-4121 52 6 853 858 20110500 read0013690/misc/11885418 Noriaki Takeda 武田 憲昭 自律神経機能異常はめまい発症に強くかかわっているか? レジデントノート別冊救急・ERノート1 218 222 20110400 read0013690/misc/11885417 Yoshiaki Kitamura 北村 嘉章 Hiroyuki Mizuguchi 水口 博之 Hiroyuki Fukui 福井 裕行 Noriaki Takeda 武田 憲昭 スプラタストのヒスタミンシグナルの抑制を介した抗アレルギー作用 頭頚部自律神経 25 33 35 20110400 read0013690/misc/11885419 Noriaki Takeda 武田 憲昭 反復するめまいへの対応 日本医事新報社 Japan Medical Journal 日本医事新報 0385-9215 0 4524 55 60 20110108 read0013690/misc/11885420 Noriaki Takeda 武田 憲昭 【お母さんへの回答マニュアル耳鼻咽喉科Q&A 2010】 耳編 めまい・動揺病 めまいはどうして起こるのでしょうか? &lt;回答のポイント&gt;1)めまいを訴える小児の年齢により，原因となるめまい疾患が異なる．2)幼児期から学童期までの小児のめまいで比較的多いのは，ウイルス感染によるめまいや内耳奇形によるめまいである．3)学童期から思春期までの小児のめまいで比較的多いのは，起立性調節障害によるめまいである．4)小児のめまいは，小脳腫瘍などの命にかかわる病気が原因の場合があるので，必ず医療機関を受診させる．(著者抄録) JOHNS 0910-6820 26 9 1294 1295 20100901 read0013690/misc/11885421 Kazunori Sekine 関根 和教 Noriaki Takeda 武田 憲昭 【内科医のための耳鼻科疾患の診かたと治療】 内科医が留意すべき耳鼻科疾患の診断と治療，予防 患者の症状から見逃さないためのコツとポイント めまい 54歳男．約2年前より左頸部リンパ節腫脹が出現しその3ヵ月後に受診し，下咽頭梨状陥凹癌，頸部リンパ節転移(T1N3M0)と診断され，放射線治療，ドセタキセルの化学療法を行った．原発巣は消失したが左頸部リンパ節転移は残存し，頸部リンパ節転移は内頸動脈に浸潤し，右ルビエールリンパ節にも転移を認めたため手術不能であった．アルコール性肝障害に汎血球減少も認め，化学療法の継続も困難で，肝障害の悪化，食欲不振，疼痛に対する補液，栄養管理，癌性疼痛緩和で入院を繰り返した．左頸部リンパ節転移が皮膚に浸潤して突出，自潰し，滲出液，悪臭が出現したため，ガーゼによる被覆も難しく，QOLも大きく低下したためMohs軟膏治療を開始した．造影CTで頸部動脈が腫瘍から離れていることを確認し，Mohs軟膏を自潰部に約1mmの厚さで塗布し，2時間後に軟膏を除去して翌日に固定された部分をメスで切除する治療を計7回毎日繰り返した．自潰した腫瘍はほぼ平坦になり，自潰部は凝固されて出血や滲出液は停止し悪臭も消失した．QOLは改善したが約1ヵ月後に原因不明の呼吸不全で死亡した．剖検よりMohs軟膏による治療部位に好塩基性物質を伴った凝固壊死組織を認め，最も深いところで表面から17mmまで及んでいた． Progress in Medicine 0287-3648 30 4 1025 1029 20100400 read0013690/misc/11885422 西池 季隆 Noriaki Takeda 武田 憲昭 渡邊 洋 【予防医学からみた耳鼻咽喉科臨床】 予防医学からみた高齢者の平衡障害 (株)東京医学社 JOHNS 0910-6820 25 12 1747 1750 20091200 read0013690/misc/11885423 Noriaki Takeda 武田 憲昭 神経科学の素朴な疑問 宇宙酔いのメカニズムはどのようなものか? Clinical Neuroscience 27 7 831 831 20090700 read0013690/misc/11885424 Noriaki Takeda 武田 憲昭 【メニエール病を理解する】 メニエール病の診断基準と検査の進め方 JOHNS 25 6 815 821 20090600 read0013690/misc/11885425 Gou Satou 佐藤 豪 Noriaki Takeda 武田 憲昭 【訴えからみためまいの見分け方】 繰り返す回転性めまい ENTONI 102 9 17 20090500 read0013690/misc/11885427 渡辺 行雄 池園 哲郎 伊藤 壽一 柿木 章伸 肥塚 泉 鈴木 衞 高橋 克昌 工田 昌也 Noriaki Takeda 武田 憲昭 土井 勝美 山下 裕司 青木 光広 宇佐美 真一 高橋 正紘 長沼 英明 メニエール病診断基準 Equilibrium Research 0385-5716 68 2 103 106 20090400 read0013690/misc/11885426 Osamu Jinnouchi 陣内 自治 Noriaki Takeda 武田 憲昭 画像診断の診かた コツとピットフォール 真菌症・悪性腫瘍との鑑別が困難であった頬部放線菌症の一例 メディカルレビュー社 深在性真菌症: SFI Forum 1880-4810 5 1 28 30 20090400 read0013690/misc/11885428 Noriaki Takeda 武田 憲昭 Naoki Toda 戸田 直紀 【耳鼻咽喉科ウイルス感染症】 めまいとウイルス感染 ENTON 99 17 23 20090300 read0013690/misc/11885429 Koichi Tamura 田村 公一 Noriaki Takeda 武田 憲昭 【異物 初期対応から摘出まで】耳鼻咽喉科領域の異物 成人例の特徴 ENTONI 96 30 35 20081200 read0013690/misc/11885430 Katsuhiko Nakamura 中村 克彦 Noriaki Takeda 武田 憲昭 Rehabilitation for a Patient with Peripheral Facial Palsy 顔面神経麻痺のリハビリテーション Synkinesis is the most unpleasant sequelae of peripheral facial palsy. It is an abnormal involuntary associate facial movement such as eye closure during smiling and mouth movement during blinking. Synkinesis strongly reduces the quality of life; however, treatment of synkinesis is difficult. We developed new rehabilitation therapies to prevent and to treat the synkinesis.&lt;br&gt;We developed a mirror biofeedback rehabilitation method to prevent synkinesis involving eye closure during mouth movement. We instructed a patient to move his mouth while keeping their eyes open symmetrically using a mirror (mirror biofeedback). Thirty minutes of daily training was continued for a period of 10 month.&lt;br&gt;To evaluate the degree of synkinesis, we computed the % eye opening, as a percent ratio of the width of the eyelid of the affected side relative to the normal side.&lt;br&gt;The % eye opening was compared between patients with and without the training. The % eye opening was significantly greater in the group with training than in the control group. This outcome indicates that our mirror biofeedback rehabilitation effectively to prevents involuntary eye closure during mouth movements.&lt;br&gt;EMG biofeedback rehabilitation is used to prevent synkinesis of involuntary mouth movement during eye closure.&lt;br&gt;To treat the synkinesis of eye closure during mouth movement, we developed a combination therapy of mirror biofeedback rehabilitation with botulinum A toxin injection. Botulinum A toxin is injected into the orbicularis oculi muscle that shows involuntary associate movement. After botulinum A toxin injection, mirror biofeedback rehabilitation was continued for a period of 10 months.&lt;br&gt;The % eye opening was compared before and after treatment. The % eye opening during mouth movement was significantly improved after treatment. This outcome indicated that combination therapy with mirror biofeedback and rehabilitation with botulinum A toxin injection is an effective treatment for facial synkinesis after facial palsy. The Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 101 6 413 421 20080601 10.5631/jibirin.101.413 read0013690/misc/11885431 Gou Satou 佐藤 豪 Noriaki Takeda 武田 憲昭 【難聴の神経学】 Meniere病 神経内科 68 5 422 428 20080500 read0013690/misc/11885432 Noriaki Takeda 武田 憲昭 【高齢者のめまい診断におけるpitfall】 高齢者のメニエール病 ENTONI 87 63 66 20080400 read0013690/misc/11885433 Yoshiaki Kitamura 北村 嘉章 Noriaki Takeda 武田 憲昭 鼻粘膜過敏性亢進における軸索反射を介した神経原性炎症の役割 アレルギーと神経ペプチド 4 33 41 20080200 read0013690/misc/11885434 Kazunori Sekine 関根 和教 Noriaki Takeda 武田 憲昭 文献検索の方法-発表，論文への応用 耳鼻咽喉科・頭頸部外科 80 1 55 64 20080100 read0013690/misc/11885435 Noriaki Takeda 武田 憲昭 めまい 耳鼻科的立場から メディカルノート症候がわかる 92 93 20071200 read0013690/misc/11885437 Jiro Udaka 宇高 二良 Koichi Tamura 田村 公一 Noriaki Takeda 武田 憲昭 呼吸理学療法排痰困難な患者への対応 排痰困難症例に対する耳鼻咽喉科的アプローチ Japanese Society of Pediatric Pulmonology 日本小児呼吸器疾患学会雑誌 0918-3876 18 1 98 101 20070600 10.5701/jjpp.18.98 read0013690/misc/11885438 Noriaki Takeda 武田 憲昭 急性めまいと慢性めまい -診断・治療の差- めまいの薬物治療のEBM評価 ENTONI 75 0 31 36 20070515 read0013690/misc/11885439 Osamu Jinnouchi 陣内 自治 Noriaki Takeda 武田 憲昭 外耳道真菌症の治療 耳鼻咽喉科・頭頸部外科 79 4 301 306 20070400 read0013690/misc/11885436 Takao Imai 今井 貴夫 Noriaki Takeda 武田 憲昭 Three-dimensional rotational axis analysis of eye movement as clinical applications 眼球運動三次元回転軸解析の臨床応用 Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 100 8 599 613 20070000 10.5631/jibirin.100.599 2-s2.0-34547929635 read0013690/misc/11885442 関根 和教 Noriaki Takeda 武田 憲昭 書字検査 JOHNS : Journal of Otolaryngology, Head & Neck Surgery 20 351 354 20040000 read0013690/misc/11885441 Noriaki Takeda 武田 憲昭 めまい・ふらつきの治療 JOHNS : Journal of Otolaryngology, Head & Neck Surgery 20 1512 1514 20040000 read0013690/misc/11885440 Noriaki Takeda 武田 憲昭 Arata Horii Suetaka Nishiike Atsuhiko Uno Neurochemical basis of spatial orientation 空間識と神経伝達物質 Japan Society for Equilibrium Research Equilibrium Research 0385-5716 63 1 1 7 20040000 10.3757/jser.63.1 2-s2.0-2442690401 read0013690/misc/11885447 北村 嘉章 三好 綾子 村田 有希 荻野 敏 福井 裕行 Noriaki Takeda 武田 憲昭 鼻過敏症動物モデルにおける鼻粘膜ヒスタミンH1受容体mRNA発現上昇とヒスタミンH1受容体拮抗薬による抑制 Journal of Japan Society of Immunology & Allergology in Otolaryngology 耳鼻咽喉科免疫アレルギー 21 2 134 135 20030000 read0013690/misc/11885446 Noriaki Takeda 武田 憲昭 関根 和教 回転検査 Otolaryngology-Head and Neck Surgery 耳鼻咽喉科・頭頸部外科 75 145 151 20030000 read0013690/misc/11885445 Noriaki Takeda 武田 憲昭 頭部外傷後のめまい 耳鼻咽喉科診療Q&A 37 406 407 20030000 read0013690/misc/11885444 Noriaki Takeda 武田 憲昭 心因性のめまい 耳鼻咽喉科診療Q&A 37 416 417 20030000 read0013690/misc/11885443 Noriaki Takeda 武田 憲昭 耳鼻咽喉科領域におけるめまい Current Therapy カレントテラピー 21 1023 1030 20030000 read0013690/misc/11885448 Noriaki Takeda 武田 憲昭 Space sickness and space medicine 宇宙医学のミニレビューと宇宙酔い In this review, physiological responses to space flight are summarized. Soon after orbital insertion, space motion sickness occurs during the first few days on orbit. The loss of body fluids is then followed by the shift of body fluids toward the head. During longer space flight, muscle atrophy, calcium loss and possible effects from cumulative radiation appear to increase continually. 徳島医学会 Shikoku Acta Medica 四国医学雑誌 0037-3699 58 6 284 288 20021225 read0013690/misc/11885449 Noriaki Takeda 武田 憲昭 めまい手術のリスクマネージメント 頭頸部外科 12 2 53 56 20021000 read0013690/misc/10681769 Kouichi Yamamoto Noriaki Takeda Atsushi Yamatodani Establishment of an animal model for radiation-induced vomiting in rats using pica Journal of Radiation Research 0449-3060 43 2 135 141 20020600 10.1269/jrr.43.135 12238327 2-s2.0-0036614964 read0013690/misc/11885451 Noriaki Takeda 武田 憲昭 抗めまい薬の使い方と薬物治療のエビデンス Medicina 39 1002 1003 20020000 read0013690/misc/11885450 Noriaki Takeda 武田 憲昭 めまい手術のリスクマネジメント Journal of Japan Society for Head and Neck Surgery 頭頸部外科 12 53 56 20020000 read0013690/misc/10681780 Changes in Fos expression in the rat brainstem after bilateral labyrinthectomy Acta Otolavyngol 1221, 620-626 null null 20020000 read0013690/misc/10681779 Establishment of an animal model for radiation-induced vowiting in rats using Pica J. Radiat. Res. 431, 135-141 null null 20020000 10.1269/jrr.43.135 read0013690/misc/10681778 Magnetic cortical responses evoked by visual linear forward acceleration Neuro Report 131, 1805-1808 null null 20020000 read0013690/misc/10681770 Changes in Fos expression in the rat brainstem after bilateral labyrinthectomy Acta Otolavyngol 1221, 620-626 null null 20020000 read0013690/misc/10681768 Magnetic cortical responses evoked by visual linear forward acceleration Neuro Report 131, 1805-1808 null null 20020000 read0013690/misc/11885452 Noriaki Takeda 武田 憲昭 めまいの薬物治療におけるEBMをこう考える Medicine and Drug Journal 医薬ジャーナル 0287-4741 37 9 134 137 20010900 read0013690/misc/11885460 Noriaki Takeda 武田 憲昭 耳鼻咽喉科疾患における抗ウイルス剤とステロイド剤の使い方 ENTONI 3 9 12 20010000 read0013690/misc/11885459 Noriaki Takeda 武田 憲昭 めまいの病因・病態 脳 214 46 50 20010000 read0013690/misc/11885458 Noriaki Takeda 武田 憲昭 荻野 仁 外耳道に生じたリンパ腫様丘疹症例 Otolaryngology-Head and Neck Surgery 耳鼻咽喉科・頭頸部外科 73 819 821 20010000 read0013690/misc/11885457 Noriaki Takeda 武田 憲昭 めまいがする:脳梗塞のめまいを見落とさないために レジデントノート 3 68 72 20010000 read0013690/misc/11885456 Noriaki Takeda 武田 憲昭 良性発作性頭位めまい症:臨床疫学と病態生理 Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 94 963 976 20010000 read0013690/misc/11885455 Noriaki Takeda 武田 憲昭 見逃してはいけないめまい The Journal of Therapy 治療 83 1941 1945 20010000 read0013690/misc/11885454 Noriaki Takeda 武田 憲昭 北原 糺 前庭代償のメカニズム JOHNS : Journal of Otolaryngology, Head & Neck Surgery 17 831 834 20010000 read0013690/misc/11885453 Noriaki Takeda 武田 憲昭 宇野 敦彦 堀井 新 ヒスタミン神経系と動揺病 Clinical Neuroscience 94 1176 1178 20010000 read0013690/misc/10681767 N. Takeda M. Morita A. Horii S. Nishiike T. Kitahara A. Uno Neural mechanisms of motion sickness Journal of Medical Investigation 1343-1420 48 1-2 44 59 20010000 11286016 2-s2.0-0035066802 read0013690/misc/10681766 M Fukushima T Kitahara N Takeda T Saika A Uno T Kubo Role of cholinergic mossy fibers in medial vestibular and prepositus hypoglossal nuclei in vestibular compensation NEUROSCIENCE 0306-4522 102 1 159 166 20010000 10.1016/S0306-4522(00)00457-7 read0013690/misc/10681765 A Uno N Takeda A Horii Y Sakata A Yamatodani T Kubo Effects of amygdala or hippocampus lesion on hypergravity-induced motion sickness in rats ACTA OTO-LARYNGOLOGICA 0001-6489 120 7 860 865 20001000 10.1080/000164800750061732 read0013690/misc/11885461 Noriaki Takeda 武田 憲昭 メニエール病の治療におけるEBM For the treatment of patients with Meniere&#039;s disease in the acute period, randomized controlled trials showed that anti-vertigo drugs, such as diphenidol and betahistine, are significantly effective. In the chronic period, Meniere&#039;s disease is specifically managed by osmotic diuretic, isosorbide. The dose comparative study showed that its opitimal dose is 90ml/day. Despite many controversies against endolymphatic sac surgery, including the Danish sham surgery study suggesting a placebo effect of mastoidectomy, the efficacy of the procedure is widely accepted. However, it is not clear that endolymphatic sac surgery alters the natural history of Meniere&#039;s disease in a long term. THE JAPAN OTOLOGICAL SOCIETY Otology Japan 0917-2025 10 3 147 149 20000725 10.11289/otoljpn1991.10.147 read0013690/misc/11885467 Noriaki Takeda 武田 憲昭 抗めまい薬の作用メカニズム Equilibrium Research 0385-5716 59 93 102 20000000 10.3757/jser.59.93 read0013690/misc/11885466 Noriaki Takeda 武田 憲昭 耳鼻咽喉科疾患による頭痛 Clinic all-round 総合臨床 49 1801 1804 20000000 read0013690/misc/11885465 Noriaki Takeda 武田 憲昭 制吐薬 JOHNS : Journal of Otolaryngology, Head & Neck Surgery 16 1311 1313 20000000 read0013690/misc/11885464 Noriaki Takeda 武田 憲昭 EBMに基づくめまい治療 Otolaryngology-Head and Neck Surgery 耳鼻咽喉科・頭頸部外科 72 873 878 20000000 read0013690/misc/11885463 Noriaki Takeda 武田 憲昭 前庭代償の分子機構 Clinical Neuroscience 18 768 770 20000000 read0013690/misc/11885462 Noriaki Takeda 武田 憲昭 中枢前庭系における平衡代償の分子機構 Shikoku Acta Medica 四国医学雑誌 0037-3699 56 132 135 20000000 read0013690/misc/11885468 Noriaki Takeda 武田 憲昭 Diagnosis and Treatment of Acute Vertigo 急性期のめまいの診断と治療 The Society of Practical Otolaryngology Practica Oto-Rhino-Laryngologica 耳鼻咽喉科臨床 0032-6313 92 1 106 107 19990100 10.5631/jibirin.92.106 read0013690/misc/10681764 N Miyazaki T Furuyama T Sakai S Fujioka T Mori Y Ohoka N Takeda T Kubo S Inagaki Developmental localization of semaphorin H messenger RNA acting as a collapsing factor on sensory axons in the mouse brain NEUROSCIENCE 0306-4522 93 1 401 408 19990000 10.1016/S0306-4522(99)00134-7 10430503 read0013690/misc/11885471 Noriaki Takeda 武田 憲昭 耳鼻咽喉科疾患とヒスタミン Journal of Clinical and Experimental Medicine 医学のあゆみ 0039-2359 184 980 980 19980000 read0013690/misc/11885470 Noriaki Takeda 武田 憲昭 久保 武 前庭神経炎の診断と治療 日耳鼻専門医通信 56 6 7 19980000 read0013690/misc/11885469 Noriaki Takeda 武田 憲昭 第8脳神経障害 Medicine and Drug Journal 医薬ジャーナル 0287-4741 35 109 111 19980000 read0013690/misc/10681763 Molecular mechanisms of vestibular compensation in the central vestibular system. acta otolarygol. Suppl.539 15 18 19980000 read0013690/misc/10681762 T Kitahara N Takeda PC Emson T Kubo H Kiyama Changes in nitric oxide synthase-like immunoreactivities in unipolar brush cells in the rat cerebellar flocculus after unilateral labyrinthectomy BRAIN RESEARCH 0006-8993 765 1 1 6 19970800 10.1016/S0006-8993(97)00436-8 9310387 read0013690/misc/10681759 S Nishiike N Takeda T Kubo S Nakamura Neurons in rostral ventrolateral medulla mediate vestibular inhibition of locus coeruleus in rats NEUROSCIENCE 0306-4522 77 1 219 232 19970300 10.1016/S0306-4522(96)00436-8 9044388 read0013690/misc/11885474 Noriaki Takeda 武田 憲昭 松永 亨 めまいとヒスタミンH1 受容体 Metabolism and Disease 代謝 0372-1566 29 23 30 19970000 read0013690/misc/11885473 Noriaki Takeda 武田 憲昭 宇野 敦彦 直線加速度負荷における生体応答解析の展望 Japanese Journal of Aerospace and Environmental Medicine 宇宙航空環境医学 34 27 30 19970000 read0013690/misc/10681761 Histamine release from the hypothalamus induced by changes in gravity in rats and its relation to space adaptation syndrome. Physiol. Behav. 61 883 887 19970000 10.1016/S0031-9384(96)00613-0 read0013690/misc/10681760 Role of the flocculus for the development of vestibular compensation : immunohistochemical studies with retrograde tracing and flocculectomy using Fos expression as a marker in the rat brainstem. Neuroscience 0306-4522 76 2 571 580 19970000 10.1016/S0306-4522(96)00374-0 9015339 read0013690/misc/10681757 N Takeda K Hashikawa H Moriwaki N Oku Koizuka, I T Kitahara N Taya T Kubo T Nishimura Effects of caloric vestibular stimulation on parietal and temporal blood flow in human brain: A consecutive technetium-99m-hmpao SPECT study JOURNAL OF VESTIBULAR RESEARCH-EQUILIBRIUM & ORIENTATION 0957-4271 6 2 127 134 19960300 read0013690/misc/11885477 Noriaki Takeda 武田 憲昭 教育講座:中枢性眼振の神経機序 Equilibrium Research 0385-5716 55 335 342 19960000 10.3757/jser.55.335 read0013690/misc/11885476 Noriaki Takeda 武田 憲昭 耳性めまいの治療 Clinics & Drug Therapy 臨床と薬物治療 15 467 469 19960000 read0013690/misc/11885475 北原 糺 Noriaki Takeda 武田 憲昭 久保 武 木山 博資 前庭代償 ブレインサイエンス 7 363 367 19960000 read0013690/misc/10681777 武田憲昭 中枢性眼振の神経機序 Equilibrium Research 0385-5716 55 4 335 342 19960000 10.3757/jser.55.335 read0013690/misc/10681758 Arata Horii Noriaki Takeda Atsushi Yamatodani Neurotransmitters in the central vestibular circuit. Neurotransmitters in the central vestibular circuit Meth. Find. Clin. Exp. Pharmacol. Methods and Findings in Experimental and Clinical Pharmacology 0379-0355 18 Suppl A 119 124 19960000 read0013690/misc/10681755 N Takeda S Hasegawa M Morita A Horii A Uno A Yamatodani T Matsunaga Neuropharmacological mechanisms of emesis .2. Effects of antiemetic drugs on cisplatin-induced pica in rats METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY 0379-0355 17 10 647 652 19951200 read0013690/misc/10681756 T KITAHARA N TAKEDA T SAIKA T KUBO H KIYAMA EFFECTS OF MK801 ON FOS EXPRESSION IN THE RAT BRAIN-STEM AFTER UNILATERAL LABYRINTHECTOMY BRAIN RESEARCH 0006-8993 700 1-2 182 190 19951100 10.1016/0006-8993(95)00950-U 8624709 read0013690/misc/10681754 N Takeda S Hasegawa M Morita A Horii A Uno A Yamatodani T Matsunaga Neuropharmacological mechanisms of emesis .1. Effects of antiemetic drugs on motion- and apomorphine-induced pica in rats METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY 0379-0355 17 9 589 596 19951100 read0013690/misc/10681776 前庭神経炎の診断および治療における問題点-突発性めまい症例の臨床的検討からの考察- 日耳鼻 98 951 958 19950000 10.3950/jibiinkoka.98.951 read0013690/misc/10681753 K OHNO T KITAHARA N TAKEDA T KUBO H KIYAMA GENE-REGULATION OF CYCLIC-AMP-DEPENDENT PROTEIN-KINASE SUBUNITS (C-ALPHA,BETA, RI-ALPHA,BETA AND RII-ALPHA,BETA) IN RAT FACIAL MOTONEURONS AFTER NERVE TRANSECTION NEUROSCIENCE 0306-4522 63 4 1101 1109 19941200 10.1016/0306-4522(94)90575-4 7700511 read0013690/misc/10681751 K OHNO N TAKEDA T KUBO H KIYAMA UP-REGULATION OF GAP-43 (B50/F1) GENE-EXPRESSION IN VESTIBULAR EFFERENT NEURONS FOLLOWING LABYRINTHECTOMY IN THE RAT - IN-SITU HYBRIDIZATION USING AN ALKALINE PHOSPHATASE-LABELED PROBE HEARING RESEARCH 1878-5891 80 1 123 127 19941000 10.1016/0378-5955(94)90016-7 7852198 read0013690/misc/10681748 A HORII N TAKEDA T MOCHIZUKI A OKAKURAMOCHIZUKI Y YAMAMOTO A YAMATODANI EFFECTS OF VESTIBULAR STIMULATION ON ACETYLCHOLINE-RELEASE FROM RAT HIPPOCAMPUS - AN IN-VIVO MICRODIALYSIS STUDY JOURNAL OF NEUROPHYSIOLOGY 0022-3077 72 2 605 611 19940800 read0013690/misc/10681750 T KITAHARA N TAKEDA K OHNO T ARAKI T KUBO H KIYAMA EXPRESSION OF GABA(A) RECEPTOR GAMMA-1 AND GAMMA-2 SUBUNITS IN THE PERIPHERAL VESTIBULAR SYSTEM OF THE RAT BRAIN RESEARCH 0006-8993 650 1 157 160 19940700 10.1016/0006-8993(94)90220-8 7953668 read0013690/misc/10681749 K OHNO N TAKEDA H KIYAMA T KUBO M TOHYAMA OCCURRENCE OF GALANIN-LIKE IMMUNOREACTIVITY IN VESTIBULAR AND COCHLEAR EFFERENT NEURONS AFTER LABYRINTHECTOMY IN THE RAT BRAIN RESEARCH 0006-8993 644 1 135 143 19940400 10.1016/0006-8993(94)90356-5 7518335 read0013690/misc/10681752 K KITAMURA M SAKAGAMI M UMEMOTO N TAKEDA K DOI T KASUGAI Y KITAMURA STRIAL DYSFUNCTION IN A MELANOCYTE DEFICIENT MUTANT RAT (WS/WS RAT) ACTA OTO-LARYNGOLOGICA 0001-6489 114 2 177 181 19940300 read0013690/misc/11885478 Noriaki Takeda 武田 憲昭 脳と免疫とクロストーク ブレインサイエンス 5 373 378 19940000 read0013690/misc/10681775 気道アレルギーと神経ペプチド ブレインサイエンス 5 373 378 19940000 read0013690/misc/10681774 Noriaki Takeda 武田 憲昭 内耳の遠心性制御 ブレインサイエンス 5 31 38 19940000 read0013690/misc/11885481 Noriaki Takeda 武田 憲昭 宇宙適応症候群の神経生化学的メカニズム 有人宇宙飛行技術研究会報告書:無重力環境における神経適応 29 37 19930000 read0013690/misc/11885480 Noriaki Takeda 武田 憲昭 久保 武 宇宙医学I:宇宙適応症候群 ブレインサイエンス 4 356 361 19930000 read0013690/misc/11885479 Noriaki Takeda 武田 憲昭 久保 武 宇宙医学II:無重力における生理学 ブレインサイエンス 4 489 492 19930000 read0013690/misc/10681747 Noriaki Takeda B Kalbi Y Abe M Irifune S Oghino Toru Matsunaga Neurogenic inflammation in nasal allergy : Histochemical and pharmacological studies in guinea pigs. A review. Neurogenic inflammation in nasal allergy: histochemical and pharmacological studies in guinea pigs. A review. Acta Otolarygol. Acta Oto-Laryngologica. Supplementum. 0365-5237 501 21 24 19930000 read0013690/misc/10681746 K Ohino Noriaki Takeda M Tanaka-Tsuji T Matsunaga Calcitonin gene-related peptide in the efferent system of the inner ear. A review. Calcitonin gene-related peptide in the efferent system of the inner ear. A review Acta Otolarygol. Acta Oto-Laryngologica. Supplementum. 0365-5237 501 16 20 19930000 read0013690/misc/10681745 Noriaki Takeda Masahiro Morita Satoshi Hasegawa Arata Horii Takeshi Kubo Toru Matsunaga Neuropharmacology of motion sickness and emesis. A review. Neuropharmacology of motion sickness and emesis. A review Acta Otolarygol. Acta Oto-Laryngologica. Supplementum. 0365-5237 501 10 15 19930000 read0013690/misc/10681744 Synaptic contact between vestibular afferent nerve and cholinergic efferent terminal : Its putative mediation by nicotinic receptors. Mol. Brain Res. 18,343-346 null null 19930000 10.1016/0169-328X(93)90100-4 read0013690/misc/10681743 Pica is analogous to emesis in rats : an animal model in emesis research. Pharmacol. Biochem. Behav. 45,817-821 null null 19930000 10.1016/0091-3057(93)90126-E read0013690/misc/10681742 Change of perproenkephalin mRNA after unilateral and bilateral labyrynthectomy in the rat medial vestibular nucleus. Mol. Brain Res. 19,237-240 null null 19930000 10.1016/0169-328X(93)90034-M read0013690/misc/10681741 Effect of unilateral vestibular stimulation on the histamine release from the hypothalamus of rats in vivo. J. Neurophysiol. 70,1822-1826 null null 19930000 read0013690/misc/11885483 Noriaki Takeda 武田 憲昭 症候の生化学:めまい Metabolism and Disease 代謝 0372-1566 29 525 533 19920000 read0013690/misc/11885482 Noriaki Takeda 武田 憲昭 組織過敏性と神経ペプチド Clinical Immunology 臨床免疫 0386-9695 24 1262 1269 19920000 read0013690/misc/10681771 めまいとヒスタミンH₁受容体 代謝 29 23 30 19920000 read0013690/misc/10681734 N TAKEDA M IGARASHI KOIZUKA, I SY CHAE T MATSUNAGA VESTIBULOOCULAR REFLEX IN ECCENTRIC ROTATION IN SQUIRREL-MONKEYS AMERICAN JOURNAL OF OTOLARYNGOLOGY 0196-0709 12 4 185 190 19910700 read0013690/misc/10681772 Noriaki Takeda 武田 憲昭 動揺病と嘔吐のメカニズム Practica Oto-Rhino-Laryngologica suppl. 耳鼻臨床(補41巻) 41 197 207 19910000 read0013690/misc/11885485 Noriaki Takeda 武田 憲昭 遠山 正弥 気道の神経支配と神経ペプチド The Journal of Clinical Science 臨床科学 26 1297 1303 19900000 read0013690/misc/11885484 Noriaki Takeda 武田 憲昭 動揺病と中枢神経系 JOHNS : Journal of Otolaryngology, Head & Neck Surgery 6 1197 1201 19900000 read0013690/misc/10681735 Recovery of the otolith-ocular reflex after unilateral deafterentation of the otolith organs in squirrel monkeys. Acta Oto-Laryngologica 110 null null 19900000 read0013690/misc/10681736 N TAKEDA M MORITA S HASEGAWA T KUBO T MATSUNAGA NEUROCHEMICAL MECHANISMS OF MOTION SICKNESS AMERICAN JOURNAL OF OTOLARYNGOLOGY 0196-0709 10 5 351 359 19890900 10.1016/0196-0709(89)90112-9 2573285 read0013690/misc/10681773 松永 亨 Noriaki Takeda 武田 憲昭 動揺病と宇宙酔い Practica Oto-Rhino-Laryngologica 耳鼻臨床 0032-6313 81,1095-1120 1095 1121 19880000 10.5631/jibirin.81.1095 read0013690/misc/11885486 Noriaki Takeda 武田 憲昭 松永 亨 和田 博 前庭自律神経反射の薬理 Japanese Journal of Neuropsychopharmacology 神経精神薬理 9 559 566 19870000 read0013690/misc/10681737 Localization and fine structure of calcitonin gene-related peptide-like immunoreactive nerre fibers in the organ of Corti of guinea pigs. Octa Oto-Laryngologica 103,567-571 null null 19870000 read0013690/misc/10681739 Histaminergic mechanism of motion sickness - Neurochemical and neuropharmacological studies of rats - Acta Oto-Laryngologica 101,416-421 null null 19860000 read0013690/misc/10681738 The presence of a calcitonin gene-related peptide in the olivocochlear bondle in rats. Experimental Brain Research 61,575-578 null null 19860000 read0013690/misc/11885487 Noriaki Takeda 武田 憲昭 渡辺 健彦 和田 博 ヒスタミン・ニューロン Japanese Journal of Neuropsychopharmacology 神経精神薬理 7 209 222 19850000 read0013690/misc/10681740 Immunohistochemical evidence for the coexistence of histidine decarboxylase-like and glutamate decarboxylase-like immunoreactivities in nerve cells. Proceedings of National Academy of Sueuce of USA 81,7647-7650 null null 19840000 10.1073/pnas.81.23.7647 read0013690/books_etc/12939803 Noriaki Takeda 武田 憲昭 前庭神経炎 Japan Medkal Journal 日本医事新報社 20170000 read0013690/books_etc/12939802 Noriaki Takeda 武田 憲昭 めまい，平衡障害 IGAKU-SHOIN Ltd.Tokyo,Japan 株式会社 医学書院 20170000 read0013690/books_etc/12939801 Yoshiaki Kitamura 北村 嘉章 Noriaki Takeda 武田 憲昭 メカニズム:生理学的機序 株式会社 最新医学社 20170000 read0013690/books_etc/12939800 Gou Satou 佐藤 豪 Noriaki Takeda 武田 憲昭 平衡機能検査 KANEHARA & CO., LTD. 金原出版 株式会社 20170000 read0013690/books_etc/12939799 Izumi Chida 千田 いづみ Koichi Tamura 田村 公一 Noriaki Takeda 武田 憲昭 先天性耳瘻孔 KANEHARA & CO., LTD. 金原出版 株式会社 20170000 read0013690/books_etc/12939804 Hiroyuki Fukui 福井 裕行 Hiroyuki Mizuguchi 水口 博之 Yoshiki Kashiwada 柏田 良樹 Hisao Nemoto 根本 尚夫 Yoshiaki Kitamura 北村 嘉章 Noriaki Takeda 武田 憲昭 Molecular pharmacology of (-)maackiain, from Kujin, an anti-allergic Kampo medicine 抗アレルギー天然物医薬，苦参の有効成分，(-)マーキアインの分子薬理機構 ヒスタミンH1受容体には，受容体刺激による遺伝子発現亢進を介する受容体アップレギュレーション機構が存在することを見いだし，タンパク質キナーゼC-δ(PKCδ)活性化を介することを明らかにした．臨床研究により，この機構が花粉症の鼻過敏症状悪化に関与し，ヒスタミンH1受容体遺伝子が疾患感受性遺伝子であることが示唆された．鼻過敏症モデルラットに対する抗ヒスタミン薬および抗アレルギー天然物医薬である苦参エキスの投与は，共に鼻過敏症状の改善とそれに相関した鼻粘膜ヒスタミンH1受容体mRNAレベル上昇の抑制を引き起こした．苦参エキスに含まれるヒスタミンH1受容体遺伝子発現抑制物質として(-)マーキアインを同定し，鼻過敏症モデルラットの鼻過敏症状に対する改善作用を明らかにした．(-)マーキアインの作用点がPKCδ活性化抑制であり，標的分子としてヒートショックタンパク質-90(Hsp90)の同定に成功した．Hsp90とPKCδは複合体を形成し，(-)マーキアインは複合体を解離させることにより，PKCδシグナルを核に伝えないと考えられた．さらに，Hsp90抑制薬が，鼻過敏症モデルラットの鼻過敏症状および鼻粘膜ヒスタミンH1受容体遺伝子発現亢進に対する改善作用を示した．以上の結果より，ヒスタミンH1受容体遺伝子が花粉症の感受性遺伝子であり，抗ヒスタミン薬はH1受容体のレベルで，苦参エキスはPKCδのレベルで改善作用を発揮することが示唆された． The Japanese Pharmacological Society 公益社団法人 日本薬理学会 20160300 read0013690/books_etc/12939806 Hiroyuki Fukui Hiroyuki Mizuguchi Yoshiaki Kitamura Noriaki Takeda Clinical significance of histamine H1 receptor gene expression and drug action of antihistamines. Springer Science, NewYork 20160000 read0013690/books_etc/12939805 Hiroyuki Fukui Hiroyuki Mizuguchi Hisao Nemoto Yoshiaki Kitamura Yoshiki Kashiwada Noriaki Takeda Histamine H1 receptor gene expression and drug action of antihistamines. Springer Science, NewYork 20160000 read0013690/books_etc/12939807 Noriaki Takeda 武田 憲昭 中耳炎 バリューメディカル 20150831 read0013690/books_etc/12939808 Noriaki Takeda 武田 憲昭 良性発作性頭位めまい症 IGAKU-SHOIN Ltd.Tokyo,Japan 株式会社 医学書院 20130000 read0013690/books_etc/12939809 Noriaki Takeda 武田 憲昭 外耳奇形 Nakayama-Shoten Co., Ltd. 株式会社 中山書店 20110500 read0013690/books_etc/12939811 Noriaki Takeda 武田 憲昭 めまい患者にメイロン注射が有効なわけは? 全日本病院出版会 20110400 read0013690/books_etc/12939810 Noriaki Takeda 武田 憲昭 どのような訴えの時に外リンパ瘻を疑うか? 20110400 read0013690/books_etc/12939812 Noriaki Takeda 武田 憲昭 Meniere病 IGAKU-SHOIN Ltd.Tokyo,Japan 株式会社 医学書院 20100000 read0013690/books_etc/12939813 Noriaki Takeda 武田 憲昭 北原 糺 宇野 敦彦 前庭系の代謝 20090500 read0013690/books_etc/12939814 Noriaki Takeda 武田 憲昭 めまい NANZANDO Co.,Ltd. 株式会社 南山堂 20070300 read0013690/books_etc/12939815 Noriaki Takeda 武田 憲昭 Approaches to Dizzy Patients without Apparent Vestibular Dysfunction 所見のないめまい患者への対応 The Society of Practical Otolaryngology 20050701 read0013690/books_etc/12939816 Noriaki Takeda 武田 憲昭 めまい診療のコツと落とし穴 Nakayama-Shoten Co., Ltd. 株式会社 中山書店 20050530 read0013690/books_etc/12939822 Noriaki Takeda 武田 憲昭 薬物性めまい 20050000 read0013690/books_etc/12939821 西池 季隆 Hironori Akizuki 秋月 裕則 Seizo Oyama 大山 晴三 渡邉 洋 松岡 克典 Noriaki Takeda 武田 憲昭 Virtual realityを用いた動揺病研究 20050000 read0013690/books_etc/12939820 Tsukasa Takaoka 高岡 司 Noriaki Takeda 武田 憲昭 亜鉛欠乏の新しい機能評価法:アンギオテンシン変換酵素活性比と味覚障害患者への応用 20050000 read0013690/books_etc/12939819 Noriaki Takeda 武田 憲昭 低音障害型感音難聴とメニエール病 20050000 read0013690/books_etc/12939818 Noriaki Takeda 武田 憲昭 めまい薬の上手な使い方 20050000 read0013690/books_etc/12939817 Noriaki Takeda 武田 憲昭 内リンパ水腫と内リンパ嚢手術 20050000 read0013690/books_etc/12939823 Noriaki Takeda 武田 憲昭 西池 季隆 耳鼻咽喉科診療プラクティス 第13巻 耳鼻咽喉科・頭頚部外科領域の外傷と異物 文光堂 20041016 read0013690/books_etc/12939824 Noriaki Takeda 武田 憲昭 耳鼻咽喉科・頭頸部外科クリニカルトレンド Part4 Nakayama-Shoten Co., Ltd. 株式会社 中山書店 20040800 read0013690/books_etc/12939825 大野 浩司 Noriaki Takeda 武田 憲昭 分子脳・神経機能解剖学 KINPODO, INC. 株式会社 金芳堂 20040600 read0013690/books_etc/12939826 Noriaki Takeda 武田 憲昭 今日の治療指針 IGAKU-SHOIN Ltd.Tokyo,Japan 株式会社 医学書院 20040000 read0013690/books_etc/12939827 Noriaki Takeda 武田 憲昭 ダイナミックメディシン 第1巻 西村書店 20030600 read0013690/books_etc/12939828 Noriaki Takeda 武田 憲昭 耳鼻咽喉科診療プラクティス 第12巻 嗅覚・味覚障害の臨床最前線 文光堂 20030520 read0013690/books_etc/12939830 Noriaki Takeda 武田 憲昭 耳鼻咽喉科薬物療法マニュアル KANEHARA & CO., LTD. 金原出版 株式会社 20030500 read0013690/books_etc/12939829 Noriaki Takeda 武田 憲昭 今日の耳鼻咽喉科頭頸部外科治療指針 第2版 IGAKU-SHOIN Ltd.Tokyo,Japan 株式会社 医学書院 20030500 read0013690/books_etc/12939831 S Ogino Noriaki Takeda T Harada Clinical Immunology and allergy in Medicine JGC Editions 20030000 read0013690/books_etc/12939832 Noriaki Takeda 武田 憲昭 看護のための最新医学講座 第21巻 耳鼻咽喉科疾患 Nakayama-Shoten Co., Ltd. 株式会社 中山書店 20020200 read0013690/books_etc/12939833 Noriaki Takeda 武田 憲昭 耳鼻咽喉科診療プラクティス 第6巻 EBMに基づくめまいの診断と治療 文光堂 20011122 read0013690/books_etc/12939834 Noriaki Takeda 武田 憲昭 CLIENT21 -21世紀耳鼻咽喉科領域の臨床 5 内耳・内耳道 Nakayama-Shoten Co., Ltd. 株式会社 中山書店 20010525 read0013690/books_etc/1330900 EBNに基づくめまいの診断と治療 文光堂 20010000 read0013690/books_etc/12939835 Noriaki Takeda 武田 憲昭 別冊「医学のあゆみ」 ヒスタミン研究の最近の進歩 Ishiyaku Publishers,Inc. 医歯薬出版 株式会社 20000700 read0013690/books_etc/12939836 Noriaki Takeda 武田 憲昭 新図説臨床耳鼻咽喉科・頭頚部外科講座 第1巻 内耳 MEDICAL VIEW CO., LTD. 株式会社 メジカルビュー社 20000400 read0013690/books_etc/12939837 Noriaki Takeda 武田 憲昭 CLIENT21 -21世紀耳鼻咽喉科領域の臨床 8 めまい・平衡障害 Nakayama-Shoten Co., Ltd. 株式会社 中山書店 19991213 read0013690/books_etc/12939838 Noriaki Takeda 武田 憲昭 内科学教科書 文光堂 19991029 read0013690/books_etc/12939839 Noriaki Takeda 武田 憲昭 NEW 耳鼻咽喉科・頭頚部外科学 Nankodo 南江堂 19990700 read0013690/books_etc/1330899 Noriaki Takeda 武田 憲昭 神経耳科学 KINPODO, INC. 金芳堂 19980000 read0013690/books_etc/12939840 Noriaki Takeda 武田 憲昭 耳鼻咽喉科・頭頚部外科クリニカルトレンド Part 2 Nakayama-Shoten Co., Ltd. 株式会社 中山書店 19980000 read0013690/books_etc/12939841 Noriaki Takeda Progress in Allergy and Clinical Immunology Hogrefe & Huber Publishers 19970700 read0013690/books_etc/12939842 Noriaki Takeda Toru Matsunaga Disorders of the Vestibular System Oxford University Press 19960115 read0013690/books_etc/1330898 Neurochemical basis of motion sickness and its treatment and prevention. Disorders of the Vestibular System, Oxford University Press 19960000 read0013690/books_etc/12939843 Noriaki Takeda 武田 憲昭 分子神経科学の最先端 ー分子から病態ー 厚生社 19950400 read0013690/books_etc/12939844 Toru Matsunaga Noriaki Takeda Histaminergic Neurons: Morphology and Function CRC Press 19910222 read0013690/books_etc/12939845 松永 亨 Noriaki Takeda 武田 憲昭 化学的神経機能解剖学 厚生社 19870600 read0013690/books_etc/12939846 Noriaki Takeda Toru Matsunaga Monoaminergic Neurons: Light Microscopy and Ultrastructure John Wiley & Sons, Inc. 19870000