label: url

en: ツツガムシ病・日本紅斑熱・SFTS

ja: ツツガムシ病・日本紅斑熱・SFTS

en: 文光堂

ja: 文光堂


en: メラノーマの危険因子 (1)環境因子，宿主因子，臨床遺伝学およびリスク評価

ja: メラノーマの危険因子 (1)環境因子，宿主因子，臨床遺伝学およびリスク評価


en: 代表的ながん遺伝子

ja: 代表的ながん遺伝子

en: IGAKU-SHOIN Ltd.Tokyo,Japan

ja: 株式会社 医学書院


en: 皮膚癌

ja: 皮膚癌


en: 血管腫・血管奇形 臨床アトラス その他血管奇形をきたしうる疾患(Cowden病，Ehles-Danlos症候群IV)

en: Nankodo

ja: 南江堂


en: 皮膚科からみた歯科との連携

ja: 皮膚科からみた歯科との連携

en: クインテッセンス

ja: クインテッセンス


en: 顔面の不整形潰瘍から疑うtrigeminal trophic syndrome

ja: 顔面の不整形潰瘍から疑うtrigeminal trophic syndrome

en: Nakayama-Shoten Co., Ltd.

ja: 株式会社 中山書店


en: Cronkhite-Canada症候群

ja: Cronkhite-Canada症候群


en: PTEN hamartoma tumor syndrome

ja: PTEN hamartoma tumor syndrome


en: Cowden病

ja: Cowden病


en: Gardner症候群

ja: Gardner症候群


en: 脂漏性皮膚炎，ふけ症

ja: 脂漏性皮膚炎，ふけ症


en: ツツガムシ病，日本紅斑熱

ja: ツツガムシ病，日本紅斑熱


en: 成人T細胞白血病・リンパ腫

ja: 成人T細胞白血病・リンパ腫


en: Verrucous carcinoma of the scalp associated with human papillomavirus type 33

en: Blackwell Publishing Ltd

ja: Blackwell Publishing Ltd

en: Verrucous carcinoma (VC) is a low-grade, well-differentiated squamous cell carcinoma of the skin or mucosae, and human papillomavirus (HPV) infection has been considered to be one of the causative factors of VC at three main sites, including the oral cavity, the genitoanal region, and the foot. However, the relationship between cutaneous VC at other sites and HPV infection remains obscure. We describe a rare case of cutaneous VC originating in a burn scar on the scalp and our attempt to find HPV infection in the lesion. We investigated the presence of HPV by polymerase chain reaction-restriction fragment length polymorphisms and immunohistochemical analysis. HPV type 33 was detected in the lesion, and positive stains for HPV were observed in several cell nuclei at the upper stratum malpighi. Since HPV type 33, as well as HPV types 16 and 18, is regarded as a high-risk, mucosal type, HPV type 33 infection likely contributed to the development of the lesion. We suggest that HPV infection should be relevant to a subset of cutaneous VC.


en: Three cases of Bowen's disease on the lower abdomen associated with high-risk types 16, 33, and 59 of human papillomavirus

en: Elsevier Science

ja: Elsevier Science


en: Bowen's disease on the sole: p16INK4a overexpression associated with human papillomavirus type 16

en: We report a case of Bowen's disease on the sole presenting clinically as an exophytic, blackish-grey, verrucous tumour, and showing human papillomavirus (HPV) type 16 on analysis with polymerase chain reaction. Positive stains for HPV particles by immunohistochemical analysis were limited to several cell nuclei at the upper stratum Malpighii. However, all the tumour cells in the epidermis exhibited strong and diffuse nuclear and cytoplasmic stains for the tumour suppressor protein p16INK4a. We speculate that dysregulation of the retinoblastoma/p16INK4a pathway may be involved in the pathogenesis of the lesion, and p16INK4a overexpression might serve as a useful surrogate marker for identifying Bowen's disease harbouring high-risk types of HPV infection.