type: misc

label: url

en: 小児・成人のためのCowden症候群/PTEN過誤腫症候群診療ガイドライン(2020年版)

en: Journal of Hereditary Tumors

ja: 遺伝性腫瘍


en: 皮膚癌

ja: 皮膚癌

en: 今日の治療指針 2019年版

ja: 今日の治療指針 2019年版


en: これが皮膚科診療スペシャリストの目線!診断・検査マニュアル―不変の知識と最新の情報― ツツガムシ病

en: MB Derma

ja: MB Derma


en: 乳幼児健診―診察のポイント&保護者の疑問・相談にこたえる 保護者の疑問・相談にこたえるために 母斑(あざ)

en: Pediatrics of Japan

ja: 小児科


en: 皮膚発癌の分子機構―最近の知見―

ja: 皮膚発癌の分子機構―最近の知見―

en: Japanese Journal of Cancer and Chemotherapy

ja: 癌と化学療法


en: ツツガムシ病，日本紅斑熱，SFTS

ja: ツツガムシ病，日本紅斑熱，SFTS

en: Monthly Book Derma

ja: Monthly Book Derma


en: 母斑:青色母斑，色素性母斑，カフェ・オ・レ斑，白斑―蒙古斑も含めて

ja: 母斑:青色母斑，色素性母斑，カフェ・オ・レ斑，白斑―蒙古斑も含めて

en: Japanese Journal of Pediatric Medicine

ja: 小児内科


en: Cowden disease (PTEN hamartoma tumor syndrome, Bannayan-Riley-Ruvalcaba syndrome, Multiple hamartoma syndrome)(カウデン病)

en: Nihon Rinsho. Japanese Journal of Clinical Medicine

ja: 日本臨牀


en: Tumorigenesis of the Epidermal Keratinocytes(the last part)Cancer

ja: 表皮角化細胞の腫瘍化メカニズム(後編)癌

en: The Nishinihon Journal of Dermatology

ja: 西日本皮膚科


en: Tumorigenesis of the Epidermal Keratinocytes(the first part)Introduction

ja: 表皮角化細胞の腫瘍化メカニズム(前編)総論


en: 今日の治療指針 2015年版

ja: 今日の治療指針 2015年版


en: ライム病

ja: ライム病

en: 皮膚疾患最新の治療 2015-2016

ja: 皮膚疾患最新の治療 2015-2016


en: 高発癌性遺伝性疾患の概要と最近の知見

ja: 高発癌性遺伝性疾患の概要と最近の知見

en: 高発癌性遺伝性疾患の中で，母斑性基底細胞癌症候群は若年の多発性基底細胞癌の発症と先天奇形を特徴とするが，欧米と比べて本邦では，基底細胞癌の発症率が低く発症年齢が高いことが明らかになってきた．Cowden病は，内臓悪性腫瘍を好発する一方で，特徴的な皮膚粘膜病変を有し，診断における皮膚科医の役割が大きい．遺伝子変異型が表現型と必ずしも一致しないまれな家系もあり，皮膚科医としてそれらの特徴と問題点をおさえておく必要がある．

en: The Japanese Journal of Dermatology

ja: 日本皮膚科学会雑誌


en: Tumorigenesis of the Epidermal Keratinocytes (the second part): Benign Tumor, Carcinoma in situ

ja: 表皮角化細胞の腫瘍化メカニズム(中編)―良性，表皮内癌―


en: Molecular carcinogenesis of the skin for development of novel therapy

ja: 皮膚発癌機構と分子標的治療薬

en: Skin cancers are considered to develop through accumulations of genetic and/or epigenetic events in normal cells of the skin. Among them, we focus on common skin cancers, including squamous cell carcinoma and melanoma. Many important molecules have been found to be involved in molecular carcinogenesis of these disorders, and some drugs targeting those molecules have been already developed. We review the updates on molecular carcinogenesis with our current works.

en: Shikoku Acta Medica

ja: 四国医学雑誌


en: 【歯科医師のための医学ハンドブック】 (Chapter 9)膠原病・免疫疾患・アレルギー疾患 金属アレルギー

en: Dental Outlook

ja: 歯界展望


en: Molecular tumorigenesis of the skin.

ja: Molecular tumorigenesis of the skin.

en: Skin tumors are supposed to develop through accumulations of genetic and/or epigenetic events in normal cells of the skin. Among them, we focus on common skin tumors, including benign, seborrheic keratosis, and malignant, squamous cell carcinoma and melanoma. Many important molecules have been detected on the molecular tumorigenesis of each of them to date, and some drugs targeted for their molecules have been already developed. We review updates on the molecular tumorigenesis of these tumors with our current works.

en: The Journal of Medical Investigation : JMI


en: 【皮膚悪性腫瘍-基礎と臨床の最新研究動向-】 有棘細胞癌(日光角化症・Bowen病) 有棘細胞癌の分子生物学と発癌機序 有棘細胞癌の遺伝子異常 概論


en: The opening of a new age in the treatment of psoriasis : Biologics

ja: 【生活の質(QOL:Quality of life)を高める医療最前線-難治な病気に光明が見えた!-】 乾癬治療に新しい時代の幕開け 生物学的製剤

en: Psoriasis is a chronic inflammatory skin disease, which is clinically characterized by scaly erythemas on the whole body. In the fully developed lesions of psoriasis, the histological features have demonstrated epidermal hyperproliferation with infiltration of T lymphocytes in the dermal papillae. Although pre-biological systemic therapies has targeted mainly proliferative keratinocytes and activated T cells, their effects were limited or these therapies could not be applied for patients with severe organ failures. Therefore, more effective agents are expected to improve quality of life (QOL) of patients with psoriasis. Recent studies have showed what kinds of cells, cell surface molecules, and cytokines should play a pivotal role in the pathogenesis of psoriasis. Biological therapies targeting these molecules have proved to be so effective for obstinate lesions of psoriasis. Here, we describe clinical features and pathogenesis of psoriasis, and the characteristics of several conventional and biological therapies for psoriasis in Japan.


en: Tumorigenesis of the Epidermal Keratinocytes

ja: 表皮角化細胞の腫瘍化機構

en: Hifuka No Rinsho

ja: 皮膚科の臨床