read0017318/misc/12857871 N Oka S Nakahara Y Takenaka T Fukumori Hogan, V F Kanayama T Yanagawa A Raz Galectin-3 inhibits tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by activating Akt in human bladder carcinoma cells CANCER RESEARCH 0008-5472 65 17 7546 7553 20050900 10.1158/0008-5472.CAN-05-1197 read0017318/misc/12857870 N Oka Y Yamamoto M Takahashi M Nishitani HO Kanayama S Kagawa Expression of angiopoietin-1 and-2, and its clinical significance in human bladder cancer BJU INTERNATIONAL 1464-4096 95 4 660 663 20050300 10.1111/j.1464-410X.2005.05358.x read0017318/misc/12857862 徳島市前立腺がん検診-平成13∼15年度3年間の比較検討- 泌尿器外科 18(8);916-920 null null 20050000 read0017318/misc/12857861 泌尿器疾患の症状の特徴 泌尿器ケア (100) null null 20050000 read0017318/misc/12857860 徳島市前立腺がん検診-平成13∼15年度3年間の比較検討- 泌尿器外科 18(8):916-920 null null 20050000 read0017318/misc/12857869 Endogenous Galectin-3 Determines the Routing of CD95 Apoptotic Signaling Pathways CANCER RESEARCH 64:3376-3379 null null 20040000 10.1158/0008-5472.CAN-04-0336 read0017318/misc/12857868 Robust Classification of Renal Cell Carcinoma Based on Gene Expression Data and Predicted Cytogenetic Profiles CANCER RESEARCH 64:4117-4121 null null 20040000 10.1158/0008-5472.CAN-04-0534 read0017318/misc/12857859 尿路散乱により発見されたredundant hymenal fimbriaの1例 西日本泌尿器科 66:411-413 null null 20040000 read0017318/misc/12857858 徳島市前立腺がん検診について 第一報:平成13年度初年度の結果に対する解析 日本泌尿器科学会雑誌 95 :3 ,596-603 null null 20040000 10.5980/jpnjurol1989.95.596 read0017318/misc/12857866 N Oka Y Okumura HO Kanayama H Izaki M Okamoto H Kido S Kagawa Amiloride and urinary trypsin inhibitor inhibit urothelial cancer invasion EUROPEAN UROLOGY 0302-2838 44 6 737 741 20031200 10.1016/S0302-2838(03)00383-X read0017318/misc/12857867 Y Yamamoto N Nishimura S Morimoto H Kitamura S Manabe H Kanayama S Kagawa T Sasaki Distinct roles of Rab3B and Rab13 in the polarized transport of apical, basolateral, and tight junctional membrane proteins to the plasma membrane BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 0006-291X 308 2 270 275 20030800 10.1016/S0006-291X(03)01358-5 read0017318/misc/12857865 The t(1;3)breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas Cancer Cell 4:405-413 null null 20030000 10.1016/S1535-6108(03)00269-1 read0017318/misc/12857864 Molecular subclassification of kidney tumors and the discovery of new diagnostic markers Oncogene 22:6810-6818 null null 20030000 read0017318/misc/12857863 Functional evaluation of one-stage urethroplasty with parameatal foreskin flaps repair of hypospadias International Journal of Urology 10:297-301 null null 20030000 10.1046/j.1442-2042.2003.00636.x read0017318/misc/12857857 徳島大学泌尿器科における小児泌尿器科医療の取り組み 西日本泌尿器科別冊 65:433-436 null null 20030000 read0017318/misc/12857856 Regression of primary murine colon cancer and occult liver metastasis by intralesional injection of lyophilized preparation of insect cells producing murine interferon-beta International Journal of Oncology 22:977-984 null null 20030000 read0017318/misc/12857852 5cm以上の副腎手術に対する腹腔鏡下副腎摘除術の検討 Japanese Journal of Endourology & ESWL 16:78-85 null null 20030000 read0017318/misc/12857790 Regression of primary murine colon cancer and occult liver metastasis by intralesional injection of lyophilized preparation of insect cells producing murine interferon-beta International Journal of Oncology 22:977-984 null null 20030000 read0017318/misc/12857855 Laparoscopic nephrectomy for dysplastic kidney in children: an initial experience International Journal of Urology 9:613-617 null null 20020000 10.1046/j.1442-2042.2002.00534.x read0017318/misc/12857854 Prognostic significance of matrix metalloproteinases-2 activation ratio in renal cell carcinoma International Journal of Urology 9:531-538 null null 20020000 10.1046/j.1442-2042.2002.00516.x read0017318/misc/12857853 目でみる泌尿器科手術のポイント:陰のう内手術 513-522 null null 20020000 read0017318/misc/12857850 徳島大学医学部泌尿器科学教室における10年間(1991年∼2000年)の外来臨床統計 西日泌尿 64;176-178 null null 20020000 read0017318/misc/12857849 徳島大学医学部泌尿器科学教室における10年間(1991年∼2000年)の入院手術統計 西日泌尿 64;104-108 null null 20020000 read0017318/misc/12857789 Laparoscopic nephrectomy for dysplastic kidney in children: an initial experience International Journal of Urology 9:613-617 null null 20020000 10.1046/j.1442-2042.2002.00534.x read0017318/misc/12857788 Prognostic significance of matrix metalloproteinases-2 activation ratio in renal cell carcinoma International Journal of Urology 9:531-538 null null 20020000 10.1046/j.1442-2042.2002.00516.x read0017318/misc/12857787 Expression of angiostatin cDNA in a murine renal cell carcinoma suppresses tumor growth in vivo Urology 59: 973-977 null null 20020000 10.1016/S0090-4295(02)01615-1 read0017318/misc/12857786 A convenient cancer vaccine therapy with in vivo transfer of interleukin 12 expression plasmid using gene gun technology after priming with irradiated carcinoma cells. Cancer Gene Ther 9(2): 156-163 null null 20020000 10.1038/sj/cgt/7700419 read0017318/misc/12857781 S Ozawa H Shinohara H Kanayama CJ Bruns CD Bucana LM Ellis DW Davis IJ Fidler Suppression of angiogenesis and therapy of human colon cancer liver metastasis by systemic administration of interferon-alpha NEOPLASIA 1522-8002 3 2 154 164 20010300 10.1038/sj.neo.7900128 read0017318/misc/12857779 H Kanayama WO Lui M Takahashi T Naroda D Kedra FI Wong Y Kuroki Y Nakahori C Larsson S Kagawa BT Teh Association of a novel constitutional translocation t(1q;3q) with familial renal cell carcinoma JOURNAL OF MEDICAL GENETICS 0022-2593 38 3 165 170 20010300 read0017318/misc/12857851 膀胱内に発生した異所性前立腺組織の1例 泌尿紀要 47;501-504 null null 20010000 read0017318/misc/12857848 徳島県における性感染症(Sexually Transmitted Disease:STD)の現状:STDセンチネル・サーベイランス調査報告(総説) 四国医学雑誌 57;166-174 null null 20010000 read0017318/misc/12857847 膀胱内に発生した異所性前立腺組織の1例 泌尿器科紀要 47 501 504 20010000 read0017318/misc/12857846 内視鏡にて空洞性病変を認めた前立腺結核の1例 日本泌尿器科学会雑誌 92 526 529 20010000 10.5980/jpnjurol1989.92.526 read0017318/misc/12857845 Cushing症候群を呈した副腎皮貭癌の1例 西日本泌尿器科 63 95 97 20010000 read0017318/misc/12857843 アンジオスタチン遺伝子導入によるin vivoマウス腎癌細胞増殖抑制効果の検討 西日本泌尿器科 63 228 232 20010000 read0017318/misc/12857842 金山 博臣 福森 知治 西谷 真明 矢野 聖二 Kim Sun Jin Ozawa Shutaro Ellis Lee M. 香川 征 Fidler Isaiah J. 腎細胞癌の進展におけるVEGFの意義 一般社団法人 日本泌尿器科学会 西日本泌尿器科 0021-5287 92 2 106 106 20010000 10.5980/jpnjurol.92.106 read0017318/misc/12857841 TAKENAKA IKUMASA 竹中 生昌 SORAMOTO SHINJI 空本 慎慈 KAGAWA SUSUMU 香川 征 KANAYAMA HIRO-OMI 金山 博臣 YOKOYAMA MASAYOSHI 横山 雅好 SHUIN TARO 執印 太郎 MORIOKA MASAAKI 森岡 政明 SUMIYOSHI YOSHITERU 住吉 義光 MULTICENTER RANDOMIZED CLINICAL TRIAL COMPARING ESTRACYT MONO-THERAPY WITH COMBINED ANDROGEN BLOCKADE THERAPY (CAB) IN THE TREATMENT OF ADVANCED PROSTATE CANCER 未治療進行前立腺癌(stage D2)に対する エストラサイト単独治療とCAB(combined androgen blockate)療法の無作為比較臨床試験成績 Nishinihon J Urol 西日本泌尿器科 0029-0726 63 1 1 9 20010000 read0017318/misc/12857785 Analysis of the gene expression of sparc and its prognostic value for bladder cancer Journal of Urolog 166(6): 2495-2499 null null 20010000 read0017318/misc/12857784 Prognostic significance of immuno-proteasome subunit expression in patients with renal-cell carcinoma: a preliminary study Molecular Urology 5 (3); 113-119 null null 20010000 read0017318/misc/12857783 Gene expression profiling of clear cell renal cell carcinoma: Gene identification and prognostic classification Proc. Natl. Acad. Sci. U.S.A. 98 (17); 9754-9759 null null 20010000 10.1073/pnas.171209998 read0017318/misc/12857782 N Oka T Fukumori M Takahashi HO Kanayama S Kagawa Secondary amyloidosis of the bladder causing macroscopic hematuria INTERNATIONAL JOURNAL OF UROLOGY 0919-8172 8 6 330 332 20010000 10.1046/j.1442-2042.2001.00309.x 11389752 read0017318/misc/12857780 Matrix metalloproteinases and bladder cancer The Journal of Medical Investigation 48 31 43 20010000 read0017318/misc/12857775 K Kanda M Takahashi Y Murakami H Kanayama S Kagawa The role of the activated form of matrix metalloproteinase-2 in urothelial cancer BJU INTERNATIONAL 1464-4096 86 4 553 557 20000900 10.1046/j.1464-410X.2000.00734.x read0017318/misc/12857844 Tromethamineによる経皮的溶解療法が有用であったシスチン結石の2例 西日本泌尿器科 62 626 629 20000000 read0017318/misc/12857840 泌尿器科疾患における血清中可溶性インターフェロン α/βレセプターの意義 日本泌尿器科学会雑誌 91 630 636 20000000 10.5980/jpnjurol1989.91.630 read0017318/misc/12857839 kock pouch, ileal neobladderの検討 西日本泌尿器科 62 246 250 20000000 read0017318/misc/12857838 腎細胞癌患者における血清可溶性interferon receptor値の臨床的意義の検討 日本泌尿器科学会雑誌 91 514 519 20000000 10.5980/jpnjurol1989.91.514 read0017318/misc/12857777 Expression of vascular endothelial growth factor isoforms and platelet-derived endothelial cell growth factor in bladder cancer Urologic Oncology 5 1 6 20000000 read0017318/misc/12857776 M. A. Nishitani T. Sakai H. O. Kanayama K. Himeno S. Kagawa Cytokine gene therapy for cancer with naked DNA Mary Ann Liebert Inc. Molecular Urology 1091-5362 4 2 47 50 20000000 10.1089/10915360050138576 2-s2.0-0034047678 read0017318/misc/12857774 Analysis of CD44 isoform v10 expression and its prognostic value in renal cell carcinoma British Journal of Urology 85 514 518 20000000 10.1046/j.1464-410X.2000.00483.x read0017318/misc/12857771 Akihiro Yamamoto Yoshiteru Sumiyoshi Noriaki Miyake Hideaki Yokozeki Hiro-Omi Kanayama Susumu Kagawa Prevention of the initial testosterone surge induced by a luteinizing hormone-releasing hormone analogue in prostate cancer patients : The endocrinological effects of pretreatment with chlormadinone acetate Journal of Medical Investigation 1343-1420 46 1-2 55 58 19990200 10408158 2-s2.0-0032714519 read0017318/misc/12857770 Masahito Tsuji Kazuya Kanda Yoshihide Murakami Yasushi Kurokawa Hiro-Omi Kanayama Toshiaki Sano Susumu Kagawa Biologic markers in prostatic intraepithelial neoplasia : Immunohistochemical and cytogenetic analyses Journal of Medical Investigation 1343-1420 46 1-2 35 41 19990200 10408155 2-s2.0-0033074041 read0017318/misc/12857837 骨転移を伴った前立腺癌におけるAlkaline phos(]E87C8[)hatase flare現象の検討 泌尿器科紀要 45 681 685 19990000 read0017318/misc/12857836 腎嚢胞内への溢流を認めた尿管結石の1例 日本泌尿器科学会雑誌 90 688 691 19990000 10.5980/jpnjurol1989.90.688 read0017318/misc/12857835 表在性膀胱癌に対するPirarubicin膀胱内注入療法による再発抑制効果の検討 癌と化学療法 26 651 655 19990000 read0017318/misc/12857834 腹腔鏡下手術の手技習得および教育について-当教室の経験より- 西日本泌尿器科 61 304 307 19990000 read0017318/misc/12857833 腎細胞癌患者における可溶性CD44およびTIM-1の検討 新薬と臨床 48 739 748 19990000 read0017318/misc/12857832 Yasushi Kurokawa Lee Kyung Soo Kin-Ya Yokota Hiro-Omi Kanayama Susumu Kagawa The so-called megaureter-megacystis syndrome: A case report いわゆるMegaureter-Magacystic Syndromeの1例 Japanese Urological Association Japanese Journal of Urology 日本泌尿器科学会雑誌 0021-5287 90 9 798 801 19990000 10.5980/jpnjurol1989.90.798 2-s2.0-6544264445 read0017318/misc/12857831 精巣悪性リンパ腫stage IE 3例の検討 西日本泌尿器科 61 135 138 19990000 read0017318/misc/12857830 コックパウチ内結石の核となった輸入脚カラーを内視鏡的に摘出した1例 泌尿器外科 12 57 60 19990000 read0017318/misc/12857829 嚢胞形成を伴った腎オンコサイトーマの1例 日本泌尿器科学会雑誌 90 49 52 19990000 10.5980/jpnjurol1989.90.49 read0017318/misc/12857828 KOJIMA KEIJI 小島 圭二 TSUJI MASAHITO 辻 雅士 KANAYAMA HIRO-OMI 金山 博臣 KAGAWA SUSUMU 香川 征 NAKAMURA SYOICHIRO 中村 章一郎 NISHITANI MASAAKI 西谷 真明 SUMITANI HARUO 炭谷 晴雄 IZAKI HIROFUMI 井崎 博文 SUMIYOSHI YOSHITERU 住吉 義光 HASHINE KATSUYOSHI 橋根 勝義 CLINICAL CHARACTERISTICS OF PATIENTS WITH ADVANCED PROSTATE CANCER WHO HAD NORMAL SERUM PSA PSAが正常値を示す進行前立腺癌の検討 西日本泌尿器科 0029-0726 61 1 12 15 19990000 read0017318/misc/12857778 H Kanayama S Yano SJ Kim S Ozawa LM Ellis IJ Fidler Expression of vascular endothelial growth factor by human renal cancer cells enhances angiogenesis of primary tumors and production of ascites but not metastasis to the lungs in nude mice CLINICAL & EXPERIMENTAL METASTASIS 0262-0898 17 10 831 840 19990000 10.1023/A:1006792007063 read0017318/misc/12857773 A case of complete testicular feminization : laparoscopic orchiectomy and analysis of androgen receptor gene mutatoin International Journal of Urology 0919-8172 6 6 327 330 19990000 10.1046/j.1442-2042.1999.00065.x 10404311 read0017318/misc/12857772 MN/CA9 gene expression as a potential biomarker in renal cell carcinoma British Journal of Urology 83 743 747 19990000 10.1046/j.1464-410x.1999.00007.x read0017318/misc/12857769 K Yokota K Kanda Y Inoue H Kanayama S Kagawa Semi-quantitative analysis of telomerase activity in exfoliated human urothelial cells and bladder transitional cell carcinoma BRITISH JOURNAL OF UROLOGY 0007-1331 82 5 727 732 19981100 read0017318/misc/12857767 A Furukawa M Tsuji M Nishitani K Kanda Y Inoue HO Kanayama S Kagawa Role of the matrix metalloproteinase and tissue inhibitors of metalloproteinase families in noninvasive and invasive tumors transplanted in mice with severe combined immunodeficiency UROLOGY 0090-4295 51 5 849 853 19980500 10.1016/S0090-4295(98)00010-7 read0017318/misc/12857756 H Kanayama K Yokota Y Kurokawa Y Murakami M Nishitani S Kagawa Prognostic values of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 expression in bladder cancer CANCER 0008-543X 82 7 1359 1366 19980400 10.1002/(SICI)1097-0142(19980401)82:7<1359::AID-CNCR20>3.3.CO;2-F 9529029 read0017318/misc/12857827 4年8ヵ月後に再燃をみた両側精巣腫瘍の1例 西日本泌尿器科 60 824 827 19980000 read0017318/misc/12857826 Kock pouch自然破壊の1例 西日本泌尿器科 60 821 823 19980000 read0017318/misc/12857825 MURAKAMI YOSHIHIDE 村上 佳秀 KANAYAMA HIRO-OMI 金山 博臣 KAGAWA SUSUMU 香川 征 IRIGUCHI HIROHIDE 入口 弘英 FUJITA JIRO 藤田 次郎 KISHIMOTO TOMOTERU 岸本 大樹 FUKUKAWA TOKUZO 福川 徳三 YONEDA FUMIO 米田 文男 NAKAJIMA MIKIO 中島 幹夫 MORIYAMA KAZUMICHI 守山 和道 SAKURAI NORITSUGU 桜井 紀嗣 EVALUATION OF METASTATIC RENAL CELL CARCINOMA IN PATIENTS SHOWING COMPLETE RESPONSE FOLLOWING INTERFERON ALPHA ADMINISTRATION インターフェロンαが著効を示した進行腎細胞癌の検討 西日本泌尿器科 0029-0726 60 11 753 757 19980000 read0017318/misc/12857824 山本 晶弘 住吉 義光 三宅 範明 横関 秀明 金山 博臣 香川 征 Pretreatment with chlormadinone acetate in prostate cancer patients treated with a luteinizing hormone-releasing hormone analogue 前立腺癌に対するLH-RHアナログ療法における酢酸クロルマジノン先行投与の有用性 未治療前立腺癌(stage B∼D)44例に対し,酢酸クロルマジノン(CMA)を4週間(I群),或いは2週間(II群)の先行投与後にluteinizing hormone-releasing hormone(LH-RH)アナログを併用し,一過性のT上昇の予防効果ならびに近接効果について検討した. 1)12週後効果判定の奏効率はI群83.3%,II群93.8%で,2群間に有意差を認めなかった. 2)LH,testosterone(T)はLH-RHアナログ初回投与3日後に2群とも有意の上昇を認めたが,治療前値よりは低値であった.PSAは2群共に有意の上昇は認めず,stage C,D症例においてflare-upと思われる症状の増悪もみられなかった.以上から,2週間のCMA先行投与によるLH-RHアナログとCMAの併用療法により,一過性のT上昇は十分予防できると考えられたWe evaluated the efficacy of pretreatment with chlormadinone acetate (CMA) in preventing the initial testosterone surge induced by luteinizing hormone-releasing hormone (LH-RH) analogue. A total of 44 patients with previously untreated prostate cancer was included in this study. Patients were randomly assigned to 2 treatment groups: Group I-CMA therapy was begun 4 weeks before the initial LH-RH analogue injection. Group II-CMA therapy was begun 2 weeks before the initial LH-RH analogue injection. After the initial LH-RH analogue injection, CMA was administered for 12 weeks or more. After LH-RH analogue application mean values of serum luteinizing hormone (LH) and testosterone increased in both groups on day 3. However, LH and testosterone levels remained below pretreatment values in both groups. CMA pretreatment reduced the mean serum PSA. The mean relative PSA level slightly increased after administration of the LH-RH analogue in group I on day 7. In group II, the mean relative PSA level decreased after LH-RH analogue administration. Objective response rates at 12 weeks were 83.3% and 93.8% in group I and group II. Our results indicate that pretreatment with CMA for 2 weeks appeared to be sufficient to prevent the initial testosterone surge induced by LH-RH analogue. 泌尿器科紀要刊行会 泌尿器科紀要 0018-1994 44 8 557 563 19980000 read0017318/misc/12857822 膀胱全摘除術と尿路変向術のすべて VI術後管理と合併症対策 3.術中合併症とその対策 腸管損傷とその対策 臨床泌尿器科 52 4 263 null 19980000 10.11477/mf.1413902301 read0017318/misc/12857821 尿中剥離細胞および摘出組織を用いた膀胱癌の分子生物学的診断 臨床泌尿器科 52 3 183 null 19980000 10.11477/mf.1413902249 read0017318/misc/12857820 膀胱癌における尿中剥離細胞の定量的テロメラーゼ活性測定の診断的意義 日本臨床 56 5 1292 null 19980000 read0017318/misc/12857819 前立腺全摘除術の適応に年齢は関与するのか? 西日本泌尿器科 60 4 301 null 19980000 read0017318/misc/12857818 MURAKAMI YOSHIHIDE 村上 佳秀 AMANO EIZOU 天野 英三 INOBE TAKUJI 伊野部 拓治 KUROKAWA YASUSHI 黒川 泰史 TAMURA MASATO 田村 雅人 KOJIMA KEIJI 小島 圭二 NARUO SEIICHI 鳴尾 精一 KANAYAMA HIRO-OMI 金山 博臣 KAGAWA SUSUMU 香川 征 LAPAROSCOPIC DIAGNOSIS OF LOCALIZATION FOR THE NONPALPABLE TESTIS 腹腔鏡によるnonpalpable testisの部位診断 西日本泌尿器科 0029-0726 60 1 8 10 19980000 read0017318/misc/12857768 Yasushi Kurokawa Keiji Kojima Hiro-Omi Kanayama Susumu Kagawa Kazushi Minami Yutaka Nakaya Activation of the Ca2+-activated K+ channel via protein kinase A-dependent phosphorylation in human prostatic smooth muscle cells Churchill Livingstone Japan International Journal of Urology 0919-8172 5 5 482 486 19980000 10.1111/j.1442-2042.1998.tb00394.x 9781439 2-s2.0-0031595296 read0017318/misc/12857764 Molecular diagnosis of bladder cancer utilizing exfoliated cancer cells and resected tumor tissues 52 3 183 null 19980000 10.11477/mf.1413902249 read0017318/misc/12857763 Quantitative analysis of telomerase activity in exfoliated urotherial cells for the diagnosis of bladder carcinoma 56 5 1292 null 19980000 read0017318/misc/12857762 A radical prostatctomy for patients with prostate cancer in elderly patients Nishinihon Journal of Urology 60 4 301 null 19980000 read0017318/misc/12857761 Laparoscopic diagnosis of localization for the nonpalpable testis Nishinihon Journal of Urology 60 1 8 null 19980000 read0017318/misc/12857759 Serum levels of soluble interleukin-2 receptor in renal cell carcinoma Urology 51 1 145 null 19980000 10.1016/S0090-4295(97)00476-7 read0017318/misc/12857758 Immunohistochemical analysis of Ki-67 antigen and Bcl-2 protein expression in prostate cancer : effect of neoadjuvant hormonal therapy British Journal of Urology 81 1 116 null 19980000 10.1046/j.1464-410X.1998.00492.x read0017318/misc/12857757 Role of the matrix metalloproteinase and tissue inhibitors of metalloproteinase families in noninvasive and invasive Tumors transplanted in mice with severe combined immunodeficiency Urology 51 5 849 null 19980000 10.1016/S0090-4295(98)00010-7 read0017318/misc/12857817 術後補助療法施行にもかかわらず5年後に再発したpure seminomaの1例 西日本泌尿器科 59 12 893 null 19970000 read0017318/misc/12857816 腎細胞癌患者における血清中可溶性インターロイキン2レセプター(sIL-2R)値測定の意義 日本泌尿器科学会雑誌 88 4 473 null 19970000 10.5980/jpnjurol1989.88.473 read0017318/misc/12857815 泌尿器科腫瘍における浸潤・転移に関わる因子 西日本泌尿器科 59 3 160 null 19970000 read0017318/misc/12857812 多房性襄胞状腎細胞癌の1例 西日本泌尿器科 59 2 128 null 19970000 read0017318/misc/12857811 ダウン症候群に合併した精巣腫瘍の1例 西日本泌尿器科 59 1 43 null 19970000 read0017318/misc/12857760 Pure seminoma recurring five years after orchiectomy in a patient who received adjuvant chemotherapy : a case report Nishinihon Journal of Urology 59 12 893 null 19970000 read0017318/misc/12857755 Kin-Ya Akiyama Masahito Tsuji Yasushi Kurokawa Kin-Ya Yokota Keiji Kojima Seiichi Naruo Hiro-Omi Kanayana Susumu Kagawa The role of serum soluble interleukin 2 receptor (sIL-2R) levels in patients with renal cell carcinoma Japanese Urological Association Japanese Journal of Urology 0021-5287 88 4 473 478 19970000 10.5980/jpnjurol1989.88.473 2-s2.0-0030971585 read0017318/misc/12857754 Factors associated with tumor invasion and metastasis in urological cancers Nishinihon Journal of Urology 59 3 160 null 19970000 read0017318/misc/12857751 Multilocular cystic renal cell carcinoma : a case report Nishinihon Journal of Urology 59 2 128 null 19970000 read0017318/misc/12857750 Testicular tumor associated with Down's syndrome : a case report Nishinihon Journal of Urology 59 1 43 null 19970000 read0017318/misc/12857747 Prognostic value of Ki-67 antigen and p53 protein in urinary bladder cancer : immunohistochemical analysis of radical cystectomy specimens Birtish Journal of Urology 79 367 null 19970000 read0017318/misc/12857743 GM Chowdhury K Kojima H Kanayama M Tsuji Y Kurokawa S Kagawa The proliferation index of MIB-1 as a prognostic factor for patients with transitional cell carcinoma of the upper urinary tract CANCER 0008-543X 78 4 827 833 19960800 10.1002/(SICI)1097-0142(19960815)78:4<827::AID-CNCR20>3.0.CO;2-W 8756378 read0017318/misc/12857814 腎血管筋脂肪腫のgrowth potentialについての検討 西日本泌尿器科 58 12 1181 null 19960000 read0017318/misc/12857813 腎血尿管癌の治療成績-特に補助化学療法の有用性について- 西日本泌尿器科 58 11 1078 null 19960000 read0017318/misc/12857810 膀股原発神経内分泌癌の1例 西日本泌尿器科 58 10 1034 null 19960000 read0017318/misc/12857809 泌尿器科領域の癌化学療法における悪心・嘔吐出現後の塩酸Granisetronの治療効果 癌と化学療法 23 7 899 null 19960000 read0017318/misc/12857808 膀股上皮内癌に対するBCG療法 西日本泌尿器科 58 7 711 null 19960000 read0017318/misc/12857807 泌尿器科悪性腫瘍における新しい測定キットを用いた血清中TPAの検討 西日本泌尿器科 58 6 697 702 19960000 read0017318/misc/12857806 KOJIMA Keiji 小島 圭二 NARUO Seiichi 鳴尾 精一 KANAYAMA Hiro-omi 金山 博臣 KAGAWA Susumu 香川 征 EVALUATION OF KI67 ANTIGEN USING MIB1 ANTIBODY AS A PROGNOSTIC FACTOR IN RENAL PELVIC AND URETERAL CANCER 腎盂尿管癌におけるMIB-1抗体を用いたKi-67抗原発現の検討 (Purpose) Recently, several reports showed that immunohistochemistry using MIB-1 antibody, which recognizes Ki-67 antigen, is one of the usefull methods to determine the proliferative activity in various cancer. To evaluate the prognostic usefulness of the MIB-1, antibody we assessed the cell proliferation immunohistochemically in urothelial cancer.<br>(Methods) The proliferative activity of thirty cases of renal pelvic and ureteral cancer has been investigated immunohistochemically using MIB-1 antibody, which recognizes Ki-67 antigen, a human nuclear antigen expressed in proliferating cells.<br>(Results) The Ki-67 index correlated with prognostic factors such as pathological stage and histological grade. The patients with early stage or low grade tumors had lower Ki-67 indices. And the Ki-67 index significantly correlated with recurrence and prognosis. The tumors of patients with recurrence or cancer death had higher Ki-67 indices. When the patients were subgrouped according to Ki-67 indices (more than 22%) had significantly worse prognosis even in the same grade. Especially in the grade 2 group, all the four patients in the higher Ki-67 index subgroup had recurred and died of cancer, whereas, in the subgrouped patients with tumors of lower Ki-67 indices, only three patients had bladder cancer recurrence, and no patients had died of cancer, except one case with advanced tumor (T4, N3, M0) resected incompletely.<br>(Conclusions) These results indicate that the Ki-67 index is a useful prognostic factor and may enhance the prognostic accuracy determined by conventional morphological grading systems. G0期以外の増殖期 (G1, S, G2, M期) にある細胞の核に発現するKi-67抗原を認識するMIB-1抗体を用いて, 腎盂尿管癌の増殖動態を免疫組織化学的に検討した. ホルマリン固定パラフィン包埋切片をMIB-1を1次抗体とするSAB法で免疫染色し, 染色された核の比率をKi-67 index とした. Ki-67 index は grade と良く相関し, grade 3のKi-67 index は grade 1, grade 2のそれと比べて有意に高値であった (p<0.01). また, stage ともに良く相関し, pT3以上の群は, pT1以下の群と比べて有意に高値であった (p<0.05). 更に, Ki-67 index は再発ならびに予後とも良く相関しており, 再発群では非再発群や膀胱内再発のみの群と比べて有意に高値 (p<0.01) であり, 癌死群ではNED (no evidence of disease) 群と比べて有意に高値であった (p<0.0001). また, Kaplan-Meier 法による生存率の比較では, Ki-67 index が22%以上の群は22%未満の群と比べ有意に予後不良であった (p<0.0001). これは, 同一 grade の症例をKi-67 index の値によって細分類した場合も同様で, Ki-67 index が22%以上の症例は有意に予後不良であった (p<0.01)<br>MIB-1抗体を用いた腎盂尿管癌に対するKi-67抗原の検討は予後を反映しており, 予後因子として有用である可能性が示唆された. The Japanese Urological Association 社団法人日本泌尿器科学会 The Japanese Journal of Urology 日本泌尿器科学会雑誌 0021-5287 87 5 822 830 19960000 10.5980/jpnjurol1989.87.822 read0017318/misc/12857805 泌尿器癌の浸潤・転移に関する分子生物学的検討 西日本泌尿器科 58 4 315 321 19960000 read0017318/misc/12857804 ヒト腎癌細胞株・膀胱癌細胞株におけるインターフェロンによる主要組織適合抗原の発現修飾 四国医学雑誌 52 2 25 32 19960000 read0017318/misc/12857753 Growth potential of angiomyolipoma Nishinihon Journal of Urology 58 12 1181 null 19960000 read0017318/misc/12857752 MATSUSHITA KAZUHIRO 松下 和弘 TANIMOTO SHUJI 谷本 修二 NARODA TAKUSHI 奈路田 拓史 YAMANAKA MASAHITO 山中 正人 YAMAMOTO AKIRA 山本 明 KAWANISHI YASUO 川西 泰夫 NUMATA AKIRA 沼田 明 YUASA MAKOTO 湯浅 誠 HASHINE KATSUYOSHI 橋根 勝義 SUMIYOSHI YOSHITERU 住吉 義光 MIYAMOTO TADAYUKI 宮本 忠幸 KANAYAMA HIROOMI 金山 博臣 TAKIGAWA HIROSHI 滝川 浩 KAGAWA SUSUMU 香川 征 Results of treatment of renal pelvic and ureteral cancer -efficacy of adjuvant chemotherapy- 腎盂尿管癌の治療成績 : 特に補助化学療法の有用性について Nishinihon Journal of Urology 西日本泌尿器科 0029-0726 58 11 1078 1084 19960000 read0017318/misc/12857749 Neuro endocrine carcinoma of the urinary bladder : a case report Nishinihon Journal of Urology 58 10 1034 null 19960000 read0017318/misc/12857748 Efficacy of Granisetron Rescue Therapy for Nausea and Vomiting Induced by Cancer Cancer Chemotherapies in Urogenital Malignant Tumor Japanese Journal Cancer Chemotherapy 23 7 899 null 19960000 read0017318/misc/12857746 Role of rBAT gene products in cystinuria International Journal of Urology 3 supple S92 null 19960000 read0017318/misc/12857745 Keiji Kojima Hisanori Uehara Sei-Ichi Naruo Hiro-Omi Kanayama Susumu Kagawa Papillary cystadenocarcinoma of the prostate Blackwell Publishing International Journal of Urology 0919-8172 3 6 511 513 19960000 10.1111/j.1442-2042.1996.tb00588.x 9170585 2-s2.0-0030467259 read0017318/misc/12857744 Serological Evaluation of Soluble CD44 in Renal Cancer Japanese Journal of Cancer Research 87 11 1191 null 19960000 10.1111/j.1349-7006.1996.tb03131.x read0017318/misc/12857742 SUMIYOSHI YOSHITERU 住吉 義光 HASHINE KATSUYOSHI 橋根 勝義 KANAYAMA HIROOMI 金山 博臣 TAKIGAWA HIROSHI 滝川 浩 KAGAWA SUSUMU 香川 征 MATSUSHITA KAZUHIRO 松下 和弘 YUASA MAKOTO 湯浅 誠 Bacillus Calmette-Guerin for intravesical treatment in patients with carcinoma in situ of the bladder 膀胱上皮内癌に対するBCG療法 Nishinihon Journal of Urology 西日本泌尿器科 0029-0726 58 7 711 714 19960000 read0017318/misc/12857741 Evaluation of serum tissue polypeptide antigen measured by a new immunoradiometric assay in urological cancer patients Nishinihon Journal of Urology 58 6 697 702 19960000 read0017318/misc/12857740 KOJIMA Keiji 小島 圭二 NARUO Seiichi 鳴尾 精一 KANAYAMA Hiro-omi 金山 博臣 KAGAWA Susumu 香川 征 Evaluation of Ki67 antigen using MIB1 antibody as a prognostic factor in renal pelvic and ureteral cancer 腎盂尿管癌におけるMIB-1抗体を用いたKi-67抗原発現の検討 (Purpose) Recently, several reports showed that immunohistochemistry using MIB-1 antibody, which recognizes Ki-67 antigen, is one of the usefull methods to determine the proliferative activity in various cancer. To evaluate the prognostic usefulness of the MIB-1, antibody we assessed the cell proliferation immunohistochemically in urothelial cancer.<br>(Methods) The proliferative activity of thirty cases of renal pelvic and ureteral cancer has been investigated immunohistochemically using MIB-1 antibody, which recognizes Ki-67 antigen, a human nuclear antigen expressed in proliferating cells.<br>(Results) The Ki-67 index correlated with prognostic factors such as pathological stage and histological grade. The patients with early stage or low grade tumors had lower Ki-67 indices. And the Ki-67 index significantly correlated with recurrence and prognosis. The tumors of patients with recurrence or cancer death had higher Ki-67 indices. When the patients were subgrouped according to Ki-67 indices (more than 22%) had significantly worse prognosis even in the same grade. Especially in the grade 2 group, all the four patients in the higher Ki-67 index subgroup had recurred and died of cancer, whereas, in the subgrouped patients with tumors of lower Ki-67 indices, only three patients had bladder cancer recurrence, and no patients had died of cancer, except one case with advanced tumor (T4, N3, M0) resected incompletely.<br>(Conclusions) These results indicate that the Ki-67 index is a useful prognostic factor and may enhance the prognostic accuracy determined by conventional morphological grading systems. G0期以外の増殖期 (G1, S, G2, M期) にある細胞の核に発現するKi-67抗原を認識するMIB-1抗体を用いて, 腎盂尿管癌の増殖動態を免疫組織化学的に検討した. ホルマリン固定パラフィン包埋切片をMIB-1を1次抗体とするSAB法で免疫染色し, 染色された核の比率をKi-67 index とした. Ki-67 index は grade と良く相関し, grade 3のKi-67 index は grade 1, grade 2のそれと比べて有意に高値であった (p<0.01). また, stage ともに良く相関し, pT3以上の群は, pT1以下の群と比べて有意に高値であった (p<0.05). 更に, Ki-67 index は再発ならびに予後とも良く相関しており, 再発群では非再発群や膀胱内再発のみの群と比べて有意に高値 (p<0.01) であり, 癌死群ではNED (no evidence of disease) 群と比べて有意に高値であった (p<0.0001). また, Kaplan-Meier 法による生存率の比較では, Ki-67 index が22%以上の群は22%未満の群と比べ有意に予後不良であった (p<0.0001). これは, 同一 grade の症例をKi-67 index の値によって細分類した場合も同様で, Ki-67 index が22%以上の症例は有意に予後不良であった (p<0.01)<br>MIB-1抗体を用いた腎盂尿管癌に対するKi-67抗原の検討は予後を反映しており, 予後因子として有用である可能性が示唆された. The Japanese Urological Association 社団法人日本泌尿器科学会 Japanese Journal of Urology 日本泌尿器科学会雑誌 0021-5287 87 5 822 830 19960000 10.5980/jpnjurol1989.87.822 read0017318/misc/12857739 Molecular biology of tumor invasion and metastasis in urological cancers Nishinihon Journal of Urology 58 4 315 321 19960000 read0017318/misc/12857738 Induction of expressions of HLA class (]G0001[) and clas (]G0002[) antigens by interferon on human renal cell carcinoma or bladder cancer cell lines Shikoku Acta Medica 52 2 25 32 19960000 read0017318/misc/12857732 A Case of Renal Cell Crcinoma producing granulocyte-Macrophage Colony-Stimulating Factor The Journal of Urology 155 2022-2023 null null 19960000 read0017318/misc/12857728 M KAN M AKI K AKIYAMA S NARUO H KANAYAMA S KAGAWA HIGH-LEVEL EXPRESSION OF THE CD44 VARIANT SHARING EXON V10 IN RENAL-CANCER JAPANESE JOURNAL OF CANCER RESEARCH 0910-5050 86 9 847 853 19950900 10.1111/j.1349-7006.1995.tb03095.x read0017318/misc/12857803 金山博臣 腎細胞癌におけるCD44変異型の発現について 日本臨床 53 7 1710 1715 19950000 read0017318/misc/12857802 von Hippel-Lindau病の1家系における遺伝子解析 西日本泌尿器科学会雑誌 86 7 1216 1220 19950000 10.5980/jpnjurol1989.86.1216 read0017318/misc/12857801 進行精巣腫瘍に対するsalvage surgeryについての検討 西日本泌尿器科 57 6 737 741 19950000 read0017318/misc/12857800 尿路上皮癌における17番染色体短腕(17p)の欠失 西日本泌尿器科 57 6 732 736 19950000 read0017318/misc/12857799 精巣腫瘍の臨床的検討-CDDP導入以後の症例について- 西日本泌尿器科 57 3 232 235 19950000 read0017318/misc/12857798 尿路上皮癌における17番染色体短腕(17P)の欠失 西日本泌尿器科 57 6.732-736 null null 19950000 read0017318/misc/12857737 KANAYAMA H. Expression of CD44 variant form in human renal cell carcinoma Nipponrinsho Jpn. J. Clin. Med. 53 7 1710 1715 19950000 read0017318/misc/12857736 H. O. Kanayama S. Naruo H. Takigawa S. Kagawa K. Kondo M. Yao T. Shuin M. Hosaka Molecular genetic analysis of a family with von Hippel-Lindau disease Japanese Urological Association Japanese Journal of Urology 0021-5287 86 7 1216 1220 19950000 10.5980/jpnjurol1989.86.1216 7637236 2-s2.0-0029095979 read0017318/misc/12857735 Salvage surgery for advanced testicular tumors Nishinihon Journal of Urology 57 6 737 741 19950000 read0017318/misc/12857734 Allelic loss of chromosome 17p in human urothelial cancer Nishinihon Journal of Urology 57 6 732 736 19950000 read0017318/misc/12857733 Clinical study of testicular tumors -after introduction of CDDP-) Nishinihon Journal of Urology 57 3 232 235 19950000 read0017318/misc/12857731 Germline mutations in the von Hippel9Lindau disease (VHL) gene in Japanese VHL Human Molecular Genetics 4 2233-2237 null null 19950000 read0017318/misc/12857730 Mutations of the basic amino acid transporter gene associated with cystinuria Biochem. J. 310 951-955 null null 19950000 read0017318/misc/12857729 Expression of CD44 splice variants in bladder cancer International Journal of Urology 2 295-301 null null 19950000 read0017318/misc/12857723 Expression of CD44 Splice Variants in Bladder Cancer International Journal of Urology 2 295 null null 19950000 read0017318/misc/12857722 High-level Expression of CD44 Variant Sharing v10 in Renal Cancer Japanese Journal of Cancer Research 86 847 null null 19950000 10.1111/j.1349-7006.1995.tb03095.x read0017318/misc/12857719 A YAMAMOTO HO KANAYAMA S NARUO H TAKIGAWA S KAGAWA THE CAMEY-LE DUC ANTIREFLUX TECHNIQUE FOR THE KOCK POUCH - EVALUATION OF THE UPPER URINARY-TRACT EUROPEAN UROLOGY 0302-2838 27 3 236 240 19950000 read0017318/misc/12857720 N MAEDA M KAMADA T DAITOH M MAEGAWA K HIRANO T AONO T SHIOTSU H KANAYAMA S KAGAWA S FUTAKI M MURAGUCHI Y OHMOTO ZG LIANG SS KOIDE IMMUNOGLOBULIN BINDING-FACTOR - A NEW TUMOR-MARKER FOR PROSTATIC TUMORS PROSTATE 0270-4137 24 3 125 130 19940300 read0017318/misc/12857797 腎細胞癌におけるインターロイキン1β(IL-1β),インターロイキン6(IL-6),腫瘍壊死因子-α(TNF-α)の血清値および遺伝子発現 日本泌尿器科学会雑誌 85 4 563 570 19940000 10.5980/jpnjurol1989.85.563 read0017318/misc/12857727 Detection of immunogloblin binding factor by enzyme-linked immunosorbent assay using two monoclonal antibodies Biochemistry and Molecular Biology Internatinal 34 4 837 844 19940000 read0017318/misc/12857726 Serum levels of a tissue inhibitor of metalloproteinases-1 (TIMP-1) in bladder cancer patients International Journal of Urology 1 2 228 230 19940000 read0017318/misc/12857721 Hiro-omi Kanayama Hiroshi Takigazva Susumii Kagazva ANALYSIS OF nm23 GENE EXPRESSIONS IN HUMAN BLADDER AND RENAL CANCERS International Journal of Urology 1442-2042 1 4 324 331 19940000 10.1111/j.1442-2042.1994.tb00058.x 7614395 2-s2.0-0028675568 read0017318/misc/12857796 膀股全摘術および尿道亜全摘術後尿道舟状窩に発生した移行上皮癌の1例 西日本泌尿器科 55 7 1138 null 19930000 read0017318/misc/12857795 前立腺肥大症に対するアリルエストレノールの臨床効果 西日本泌尿器科 55 8 1295 null 19930000 read0017318/misc/12857794 Ileal reobladder 西日本泌尿器科 55 4 504 null 19930000 read0017318/misc/12857793 Kock Pouch-合併症減少を目的とした手抜の改良- 西日本泌尿器科 55 4 498 null 19930000 read0017318/misc/12857792 膀胱癌におけるタイプ(]G0004[)コラゲナーゼとTissue inhibitor of mefalloproteinases(TIMP)の遺伝子発現についての検討 日本泌尿器科学会雑誌 84 5 841 null 19930000 10.5980/jpnjurol1989.84.841 read0017318/misc/12857718 Occurrence of fransitional cell carcinoma in the fossa navicularis of the urethra folloming total cystectomy and subtotal urethrectomy : a case report 55 7 1138 null 19930000 read0017318/misc/12857717 Clinical evaluation of Allylesterenol for the treatment of benign prostatic hypertrophy 55 8 1295 null 19930000 read0017318/misc/12857716 Ileal reobladder 55 4 504 null 19930000 read0017318/misc/12857715 Modified technique of Kock continent ileal reservoir for reducing postoperative complications. 55 4 498 null 19930000 read0017318/misc/12857714 Endourological Management of complications of Kock Pouch and Ileal Condint Japanese Journal of Endourology and ESWL 6 2 175 null 19930000 read0017318/misc/12857713 S. Naruo H. Kanayama M. Aki S. Kagawa Gene expression of type IV collagenase and tissue inhibitor of metalloproteinases (TIMP) in human bladder cancers Japanese Journal of Urology 0021-5287 84 5 841 850 19930000 10.5980/jpnjurol1989.84.841 8320889 2-s2.0-0027213421 read0017318/misc/12857711 Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms Europian Journal of Biochemistry 206 null null 19920000 10.1111/j.1432-1033.1992.tb16961.x read0017318/misc/12857791 泌尿器癌におけるプロテアソーム(多機能プロテアーゼ複合体)の変動 西日本泌尿器科 53 4 null null 19910000 read0017318/misc/12857712 Alteratious of Proteasomes(multicatalytic proteinase complexes)in urological Cancers. 53 4 null null 19910000 read0017318/misc/12857710 Changes in Expressions of Proteasome and Ubiquitin Genes in Human Renal Cancer Cells Cancer Research 51 24 null null 19910000 read0017318/misc/12857725 K TANAKA H KANAYAMA T TAMURA DH LEE A KUMATORI T FUJIWARA A ICHIHARA F TOKUNAGA R ARUGA S IWANAGA CDNA CLONING AND SEQUENCING OF COMPONENT C8 OF PROTEASOMES FROM RAT HEPATOMA-CELLS BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 0006-291X 171 2 676 683 19900900 10.1016/0006-291X(90)91199-3 2403356 read0017318/misc/12857724 Altered Kinetic Properties of A Mutant Adenine Phosphoribosyltransferase Metabolism 35 187-192 null null 19860000 read0017318/misc/12857823 原発性膀胱上皮内癌に対する膀胱温存治療と膀胱全摘除 西日本泌尿器科 null null read0017318/misc/12857765 Bladder preservation therapy and total cystectomy for primary carcinoma in situ of the Uninay blads Nishinihon Journd of Urology null null read0017318/books_etc/1798014 症例呈示・小児例-尿管胃所開口を伴う右低形成腎- 腹腔鏡下腎・副腎摘徐術-腎篇 診断と治療社，東京 19960000 read0017318/books_etc/1798013 Abnormal expression of proteasomes (multicatalytic proteinase complexes) in human renal cancers SOCIETE INTERNATIONALE D'UROLOGIE REPORTS -ONCOGENES AND MOLECULAR GENETICS OF UROLOGICAL TUMORS- Edited by C A Olsson. Churchill livingstone. London. 19920000 徳島新聞・安芸花江医学助成金 20000000 財団法人康楽会賞 19970000 重松賞(日本泌尿器科学会西日本総会) 19960000