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en: Dental Treatment under General Anesthesia in Tokushima University Hospital - Safety Management of Disabled Patients with Special Needs during Dental Treatment-

ja: 当院における全身麻酔下歯科治療について -障害をもつ方へ安全な歯科治療の提供-

en: We report about general anesthesia for disabled patients with special needs or young children during dental treatment in Tokushima University Hospital. We have administered ambulatory anesthesia or general anesthesia with short-term hospitalization for the patients. In this report, we showed anesthesia as a behavior management technique and the system for the patients who schedule ambulatory anesthesia in our hospital. We indicated the present situation of dental treatment under general anesthesia and supposed the prospects of dental care for the patients with special needs.

en: Journal of Oral Health and Biosciences

ja: Journal of Oral Health and Biosciences


en: 2.カリウムチャネルと循環 --- 第37回総会シンポジウム2「神経調節による循環制御」

en: 循環制御

ja: 循環制御


en: Anesthetic Cardioprotection in Relation to Mitochondria: Basic Science.

en: Anesthetic pre- and postconditioning pharmacologically reduce ischemia/reperfusion injury. Mitochondria play a central role in these myocardial protective salvage effects. In the preconditioning, low levels of reactive oxygen species, which are produced by anesthetics in the mitochondria, act as a trigger to prevent cardiomyocytes death and modify intracellular signaling mechanisms. In the postconditioning, decreased mitochondrial matrix pH, which was caused by anesthetics, triggers the onset of a rapid protective effect. The mitochondrial membranes have several ion channels that act as major determining factors of cellular life and death under pathophysiological conditions. In these channels, the mitochondrial adenosine triphosphate-sensitive K+ channels, the mitochondrial Ca2+-activated K+ channels and mitochondrial permeability transition pores play critical roles in cardioprotection against ischemia/reperfusion injury. Mitochondrial permeability transition pores are end effectors, which contribute to myocardial preconditioning and postconditioning. Activation of intracellular signaling and acidification of mitochondrial matrix pH prevent the mitochondrial permeability transition pore opening, and therefore, preserve the mitochondrial function to supply adenosine triphosphate, resulting in myocardial protection due to the maintenance of intracellular homeostasis.

en: Current Pharmaceutical Design

ja: Current Pharmaceutical Design


en: Principles, Usefulness, and Limitations of Recent Circulatory Monitoring --- 「循環系:心拍出量モニタリングを中心に」

ja: 特集 モニタリングを検証する --- 「循環系:心拍出量モニタリングを中心に」

en: Masui

ja: 麻酔


en: 麻酔と周術期心筋虚血

ja: 麻酔と周術期心筋虚血

en: Shikoku Dental Research

ja: 四国歯学会雑誌


en: Intensive insulin therapy during cardiovascular surgery.

en: Recent evidence in the fields of surgery, emergency and critical care medicine indicates that strict glycemic control results in lower mortality. Hyperglycemia occurs frequently in patients with and without diabetes during cardiovascular surgery, especially during cardiopulmonary bypass. However, strict glucose control is difficult to achieve during cardiovascular procedures. To establish effective intensive insulin therapy during cardiovascular surgery, we conduct continuous blood glucose monitoring and employ automatic control by using an artificial endocrine pancreas (the STG-22, Nikkiso, Tokyo, Japan). In this review, we will outline the present status and problems of conventional glycemic control for perioperative cardiovascular surgery and introduce the new perioperative blood glucose management method that we are testing now. We will also discuss the importance of perioperative glycemic control for cardiovascular surgery as well as future prospects.

en: The Journal of Medical Investigation : JMI


en: VIII 循環作動薬 アルプロスタジル

ja: VIII 循環作動薬 アルプロスタジル

en: 麻酔薬および麻酔関連薬使用ガイドライン 第3版

ja: 麻酔薬および麻酔関連薬使用ガイドライン 第3版


en: Problems associated with glucose toxicity: Role of hyperglycemia-induced oxidative stress.

en: Glucose homeostasis deficiency leads to a chronic increase in blood glucose concentration. In contrast to physiological glucose concentration, chronic superphysiological glucose concentration negatively affects a large number of organs and tissues. Glucose toxicity means a decrease in insulin secretion and an increase in insulin resistance due to chronic hyperglycemia. It is now generally accepted that glucose toxicity is involved in the worsening of diabetes by affecting the secretion of beta-cells. Several mechanisms have been proposed to explain the adverse effects of hyperglycemia. It was found that persistent hyperglycemia caused the functional decline of neutrophils. Infection is thus the main problem resulting from glucose toxicity in the acute phase. In other words, continued hyperglycemia is a life-threatening risk factor, not only in the chronic but also the acute phase, and it becomes a risk factor for infection, particularly in the perioperative period.

en: World Journal of Gastroenterology : WJG

ja: World Journal of Gastroenterology : WJG


en: 2. 虚血性心疾患 TEEセミナー「私のルーチン」

ja: 2. 虚血性心疾患 TEEセミナー「私のルーチン」

en: Cardiovascular Anesthesia

ja: Cardiovascular Anesthesia


en: 心エコー・ドプラ法の新技術 --- -後方散乱エコーとストレイン/ストレインレート-

en: 日本臨床麻酔学会誌

ja: 日本臨床麻酔学会誌


en: [Intraoperative application of transesophageal echocardiography]. --- 経食道心エコーによる術中モニタリング

ja: 生体機能検査による術中モニタリング (5) --- 経食道心エコーによる術中モニタリング

en: Transesophageal echocardiography (TEE) has become a routine monitor in the operating room for cardiac surgery because it provides instantaneous and continuous assessment of cardiac function and anatomy. TEE aids intraoperative management and improves outcome in patients undergoing cardiac valve repairs, complex congenital heart corrections, and high-risk patients undergoing coronary artery bypass graft surgery. Especially in mitral valve repair surgery, it is mandatory to evaluate the results of the surgical procedure after cardiopulmonary bypass during surgery. Multiple investigations have also documented the improved sensitivity of TEE for the detection of myocardial ischemia compared with ECG or pulmonary capillary wedge pressure measurements. Intraoperative TEE is, however, not without risks, so emerging evidence demonstrating the utility of TEE as a diagnostic monitor or to alter the management of patients is required, especially in non-cardiac surgery. TEE is less frequently used in non-cardiac surgery; however, the emergent use of intraoperative or perioperative TEE to determine the cause of an acute, persistent, and life-threatening hemodynamic abnormality is well indicated. A task force of the American Society of Anesthesiologists and the Society of Cardiovascular Anesthesiologists developed guidelines for the appropriate use of TEE, which were evidence-based and focused on the effectiveness of perioperative TEE in improving clinical outcomes. Compliance with the guidelines for basic intraoperative TEE resulted in a marked improvement in intraoperative TEE practice. Technical progress of echocardiographic equipment and the TEE probe will increase the application of intraoperative and perioperative TEE in the future.

en: The Official Journal of Japanese Society of Laboratory Medicine

ja: 臨床病理


en: 小児麻酔における経食道心エコーの功罪

ja: 小児麻酔における経食道心エコーの功罪


en: 実践麻酔シリーズ --- 経食道心エコー:重要ポイントはこれだ

ja: 実践麻酔シリーズ --- 経食道心エコー:重要ポイントはこれだ

en: Anesthesia Network

ja: Anesthesia Network


en: 手術中の不整脈 -原因，診断，治療-

ja: 手術中の不整脈 -原因，診断，治療-

en: 麻酔


en: 特集「吸入麻酔薬と冠循環」 --- 吸入麻酔薬とcoronary steal現象


en: 経食道心エコーの術中応用-最近の話題 --- 麻酔中のモニタリング-最近の話題

ja: 経食道心エコーの術中応用-最近の話題 --- 麻酔中のモニタリング-最近の話題


en: 吸入麻酔薬とcoronary steal -最近の動向-

ja: 吸入麻酔薬とcoronary steal -最近の動向-

en: 循環制御


en: 心臓血管系の超音波ドプラー法 -麻酔科領域(Ⅱ)- --- 経食道カラードプラ心エコーの術中応用


en: Applications of transesophageal two-dimensional color Doppler echocardiography in cardiac anesthesia --- Present and future

en: Medical Review

ja: Medical Review