{"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=405345","label":"url"}],"paper_title":{"en":"Raman Microspectroscopy for Label-Free Diagnosis of Amyloid Light-chain Amyloidosis in Various Organs","ja":"Raman Microspectroscopy for Label-Free Diagnosis of Amyloid Light-chain Amyloidosis in Various Organs"},"authors":{"en":[{"name":"Yanagiya Shin-ichiro"},{"name":"Honda Takeshi"},{"name":"Takanari Hiroki"},{"name":"Sogabe Kimiko"},{"name":"Nakamura Shingen"},{"name":"Bando Yoshimi"},{"name":"Abe Masahiro"},{"name":"Miki Hirokazu"}],"ja":[{"name":"柳谷 伸一郎"},{"name":"本田 剛士"},{"name":"髙成 広起"},{"name":"曽我部 公子"},{"name":"中村 信元"},{"name":"坂東 良美"},{"name":"安倍 正博"},{"name":"三木 浩和"}]},"publication_date":"2024-02","publication_name":{"en":"Journal of Raman Spectroscopy","ja":"Journal of Raman Spectroscopy"},"languages":["eng"],"referee":true,"identifiers":{"issn":["0377-0486"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=404094","label":"url"}],"paper_title":{"en":"線維化と腫瘍随伴リンパ組織増生を伴う粘表皮癌の1例","ja":"線維化と腫瘍随伴リンパ組織増生を伴う粘表皮癌の1例"},"authors":{"en":[{"name":"富田 満"},{"name":"Ogawa Hirohisa"},{"name":"Tsunematsu Takaaki"},{"name":"Sato Mami"},{"name":"山下 貴央"},{"name":"Kitamura Yoshiaki"},{"name":"Ishimaru Naozumi"},{"name":"Tsuneyama Koichi"},{"name":"Uehara Hisanori"},{"name":"Bando Yoshimi"}],"ja":[{"name":"富田 満"},{"name":"小川 博久"},{"name":"常松 貴明"},{"name":"佐藤 真美"},{"name":"山下 貴央"},{"name":"北村 嘉章"},{"name":"石丸 直澄"},{"name":"常山 幸一"},{"name":"上原 久典"},{"name":"坂東 良美"}]},"publication_date":"2023-10","publication_name":{"en":"診断病理","ja":"診断病理"},"volume":"Vol.40","number":"No.4","starting_page":"336","ending_page":"341","languages":["jpn"],"referee":true,"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/118771","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/37940520","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=403775","label":"url"}],"paper_title":{"en":"Early Prediction of Radiotherapeutic Effecacy in a Mouse Model of Non-Small Cell Lung Carcinoma Using 18F-FLT and 18F-FDG PET/CT","ja":"Early Prediction of Radiotherapeutic Effecacy in a Mouse Model of Non-Small Cell Lung Carcinoma Using 18F-FLT and 18F-FDG PET/CT"},"authors":{"en":[{"name":"Ohtani Tamaki"},{"name":"Ikushima Hitoshi"},{"name":"Bando Yoshimi"},{"name":"Yamashita Michiko"},{"name":"Kuwahara Kenmei"},{"name":"Otsuka Hideki"},{"name":"Kondo Kazuya"},{"name":"Miyoshi Hirokazu"}],"ja":[{"name":"大谷 環樹"},{"name":"生島 仁史"},{"name":"坂東 良美"},{"name":"山下 理子"},{"name":"Kuwahara Kenmei"},{"name":"大塚 秀樹"},{"name":"近藤 和也"},{"name":"三好 弘一"}]},"description":{"en":"This study investigated the usefulness of [18F]-3'-deoxy-3'-fluorothymidine (18F-FLT) and [18F]-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) imaging for predicting the therapeutic efficacy of non-small cell lung cancer (NSCLC) irradiation at an early stage after radiation treatment. Mice were xenografted with the human lung adenocarcinoma line A549 or large cell lung cancer line FT821. Tumour uptake of 18F-FLT and 18F-FDG was imaged using PET/CT before and 1 week after irradiation. In A549 tumours, 18F-FLT uptake was significantly decreased, and 18F-FDG uptake was unchanged post-irradiation compared with pre-irradiation. In FT821 tumours, uptake of both 18F-FLT and 18F-FDG uptake was substantially decreased post-irradiation compared with pre-irradiation. In both xenografts, tumour volumes in the irradiated groups were significantly decreased compared with those in the control group. 18F-FLT is expected to contribute to individual NSCLC therapy because it accurately evaluates the decrease in tumour activity that cannot be captured by 18F-FDG. 18F-FDG may be useful for evaluating surviving cells without being affected by the inflammatory reaction at an extremely early stage, approximately 1 week after irradiation. Combined use of 18F-FLT and 18F-FDG PET/CT imaging may increase the accurate prediction of radiotherapy efficacy, which may lead to improved patient outcomes and minimally invasive personalised therapy. J. Med. Invest. 70 : 361-368, August, 2023.","ja":"This study investigated the usefulness of [18F]-3'-deoxy-3'-fluorothymidine (18F-FLT) and [18F]-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) imaging for predicting the therapeutic efficacy of non-small cell lung cancer (NSCLC) irradiation at an early stage after radiation treatment. Mice were xenografted with the human lung adenocarcinoma line A549 or large cell lung cancer line FT821. Tumour uptake of 18F-FLT and 18F-FDG was imaged using PET/CT before and 1 week after irradiation. In A549 tumours, 18F-FLT uptake was significantly decreased, and 18F-FDG uptake was unchanged post-irradiation compared with pre-irradiation. In FT821 tumours, uptake of both 18F-FLT and 18F-FDG uptake was substantially decreased post-irradiation compared with pre-irradiation. In both xenografts, tumour volumes in the irradiated groups were significantly decreased compared with those in the control group. 18F-FLT is expected to contribute to individual NSCLC therapy because it accurately evaluates the decrease in tumour activity that cannot be captured by 18F-FDG. 18F-FDG may be useful for evaluating surviving cells without being affected by the inflammatory reaction at an extremely early stage, approximately 1 week after irradiation. Combined use of 18F-FLT and 18F-FDG PET/CT imaging may increase the accurate prediction of radiotherapy efficacy, which may lead to improved patient outcomes and minimally invasive personalised therapy. J. Med. Invest. 70 : 361-368, August, 2023."},"publication_date":"2023-08","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.70","number":"No.3,4","starting_page":"361","ending_page":"368","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.70.361"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/37355721","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=399092","label":"url"}],"paper_title":{"en":"Insulin receptor expression to predict resistance to axitinib and elucidation of the underlying molecular mechanism in metastatic renal cell carcinoma.","ja":"Insulin receptor expression to predict resistance to axitinib and elucidation of the underlying molecular mechanism in metastatic renal cell carcinoma."},"authors":{"en":[{"name":"Takahashi Masayuki"},{"name":"Daizumoto Kei"},{"name":"Fukawa Tomoya"},{"name":"Fukuhara Yayoi"},{"name":"Bando Yoshimi"},{"name":"Kowada Minoru"},{"name":"Dondoo Tsogt-Ochir"},{"name":"Sasaki Yutaro"},{"name":"Tomida Ryotaro"},{"name":"Ueno Yoshiteru"},{"name":"Tsuda Megumi"},{"name":"Kusuhara Yoshito"},{"name":"Yamaguchi Kunihisa"},{"name":"Yamamoto Yasuyo"},{"name":"Uehara Hisanori"},{"name":"Kanayama Hiroomi"}],"ja":[{"name":"高橋 正幸"},{"name":"大豆本 圭"},{"name":"布川 朋也"},{"name":"福原 弥生"},{"name":"坂東 良美"},{"name":"Kowada Minoru"},{"name":"Dondoo Tsogt-Ochir"},{"name":"佐々木 雄太郎"},{"name":"Tomida Ryotaro"},{"name":"Ueno Yoshiteru"},{"name":"津田 恵"},{"name":"楠原 義人"},{"name":"山口 邦久"},{"name":"山本 恭代"},{"name":"上原 久典"},{"name":"Kanayama Hiroomi"}]},"description":{"en":"Decreased INSR in RCC could be a biomarker to predict axitinib resistance. Regarding the resistant mechanism, vascular endothelial cells with decreased INSR in RCC may secrete interferon-β and induce PD-L1.","ja":"Decreased INSR in RCC could be a biomarker to predict axitinib resistance. Regarding the resistant mechanism, vascular endothelial cells with decreased INSR in RCC may secrete interferon-β and induce PD-L1."},"publication_date":"2023-06-24","publication_name":{"en":"British Journal of Cancer","ja":"British Journal of Cancer"},"languages":["eng"],"referee":true,"identifiers":{"doi":["10.1038/s41416-023-02325-8"],"issn":["1532-1827"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=397814","label":"url"}],"paper_title":{"en":"Dynamic contrast-enhanced MR imaging of uterine endometrial carcinoma with/without squamous differentiation","ja":"Dynamic contrast-enhanced MR imaging of uterine endometrial carcinoma with/without squamous differentiation"},"authors":{"en":[{"name":"Takeuchi Mayumi"},{"name":"Matsuzaki Kenji"},{"name":"Bando Yoshimi"},{"name":"Harada Masafumi"}],"ja":[{"name":"竹内 麻由美"},{"name":"松崎 健司"},{"name":"坂東 良美"},{"name":"原田 雅史"}]},"description":{"en":"Purpose: Endometrial carcinoma with strong enhancement on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is suggestive of high-grade type II endometrial carcinoma. However, low-grade type I endometrial carcinoma may also sometimes show strong enhancement. We hypothesized that squamous differentiation would contribute to the strong enhancement at the early phase on DCE-MRI-like uterine cervical squamous cell carcinoma and compared the DCE-MRI findings of endometrial carcinoma with and without squamous differentiation. Methods: DCE-MRI of endometrial carcinoma including 41 low-grade type I endometrial carcinomas without squamous differentiation (LG), 39 low-grade type I endometrial carcinomas with squamous differentiation (LGSD), and 20 high-grade type II endometrial carcinomas (HG) was retrospectively evaluated. Results: Significant difference in the time-intensity curves was found between LG and HG and LG and LGSD, whereas no significant difference was seen between HG and LGSD. Curve type 3 (initial signal rise which is steeper than that of the myometrium) was more frequent in HG (60%) and LGSD (77%) than in LG (34%). Conclusion: It should be recognized as a pitfall that high-grade type II endometrial carcinoma and low-grade type I endometrial carcinoma with squamous differentiation may show similar early strong enhancement on DCE-MRI.","ja":"Purpose: Endometrial carcinoma with strong enhancement on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is suggestive of high-grade type II endometrial carcinoma. However, low-grade type I endometrial carcinoma may also sometimes show strong enhancement. We hypothesized that squamous differentiation would contribute to the strong enhancement at the early phase on DCE-MRI-like uterine cervical squamous cell carcinoma and compared the DCE-MRI findings of endometrial carcinoma with and without squamous differentiation. Methods: DCE-MRI of endometrial carcinoma including 41 low-grade type I endometrial carcinomas without squamous differentiation (LG), 39 low-grade type I endometrial carcinomas with squamous differentiation (LGSD), and 20 high-grade type II endometrial carcinomas (HG) was retrospectively evaluated. Results: Significant difference in the time-intensity curves was found between LG and HG and LG and LGSD, whereas no significant difference was seen between HG and LGSD. Curve type 3 (initial signal rise which is steeper than that of the myometrium) was more frequent in HG (60%) and LGSD (77%) than in LG (34%). Conclusion: It should be recognized as a pitfall that high-grade type II endometrial carcinoma and low-grade type I endometrial carcinoma with squamous differentiation may show similar early strong enhancement on DCE-MRI."},"publication_date":"2023-05-08","publication_name":{"en":"Abdominal Radiology","ja":"Abdominal Radiology"},"volume":"Vol.48","number":"No.8","starting_page":"2494","ending_page":"2502","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s00261-023-03934-w"],"issn":["2366-0058"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/36697028","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=393829","label":"url"}],"paper_title":{"en":"MR Imaging Findings of Uterine Adenomatoid Tumors.","ja":"MR Imaging Findings of Uterine Adenomatoid Tumors."},"authors":{"en":[{"name":"Takeuchi Mayumi"},{"name":"Matsuzaki Kenji"},{"name":"Bando Yoshimi"},{"name":"Harada Masafumi"}],"ja":[{"name":"竹内 麻由美"},{"name":"松崎 健司"},{"name":"坂東 良美"},{"name":"原田 雅史"}]},"description":{"en":"Adenomatoid tumor is a rare benign genital tract neoplasm of mesothelial origin. Uterine adenomatoid tumors occur in the outer myometrium and may mimic leiomyomas. Because hormonal treatment is not applicable to adenomatoid tumors and laparoscopic enucleation is not easy as myomectomy, it is important to differentiate adenomatoid tumors from leiomyomas for the adequate treatment. The purpose of this study is to evaluate the MRI findings of adenomatoid tumor for the differentiation from leiomyoma. MRI findings of surgically proven 10 uterine adenomatoid tumors in 9 women were retrospectively evaluated with correlation to histopathological findings. All 10 tumors appeared as solid myometrial masses and showed heterogeneous signal intensity with admixture of partially ill-defined slight high-intensity areas containing abundant tubular tumor cells and well-defined myoma-like low-intensity areas reflecting smooth muscle hypertrophy on T2WI including 4 lesions with peripheral ring-like high intensity. High-intensity areas on T2WI tended to show high intensity on diffusion-weighted imaging (DWI) with relatively high apparent diffusion coefficient (ADC), suggesting T2 shine-through effect due to abundant tubules. Intra-tumoral hemorrhage revealed on MRI was rare. Early intense contrast-enhanced areas on dynamic contrast-enhanced study were observed dominantly within the high-intensity areas but rarely within the low-intensity areas on T2WI. The outer myometrial mass with the admixture of well-defined low- and ill-defined high-intensity areas on T2WI may be suggestive of adenomatoid tumor. Peripheral ring-like high intensity on T2WI and DWI may also be suggestive. Dynamic contrast-enhanced MR study may be helpful for the differentiation from leiomyoma.","ja":"Adenomatoid tumor is a rare benign genital tract neoplasm of mesothelial origin. Uterine adenomatoid tumors occur in the outer myometrium and may mimic leiomyomas. Because hormonal treatment is not applicable to adenomatoid tumors and laparoscopic enucleation is not easy as myomectomy, it is important to differentiate adenomatoid tumors from leiomyomas for the adequate treatment. The purpose of this study is to evaluate the MRI findings of adenomatoid tumor for the differentiation from leiomyoma. MRI findings of surgically proven 10 uterine adenomatoid tumors in 9 women were retrospectively evaluated with correlation to histopathological findings. All 10 tumors appeared as solid myometrial masses and showed heterogeneous signal intensity with admixture of partially ill-defined slight high-intensity areas containing abundant tubular tumor cells and well-defined myoma-like low-intensity areas reflecting smooth muscle hypertrophy on T2WI including 4 lesions with peripheral ring-like high intensity. High-intensity areas on T2WI tended to show high intensity on diffusion-weighted imaging (DWI) with relatively high apparent diffusion coefficient (ADC), suggesting T2 shine-through effect due to abundant tubules. Intra-tumoral hemorrhage revealed on MRI was rare. Early intense contrast-enhanced areas on dynamic contrast-enhanced study were observed dominantly within the high-intensity areas but rarely within the low-intensity areas on T2WI. The outer myometrial mass with the admixture of well-defined low- and ill-defined high-intensity areas on T2WI may be suggestive of adenomatoid tumor. Peripheral ring-like high intensity on T2WI and DWI may also be suggestive. Dynamic contrast-enhanced MR study may be helpful for the differentiation from leiomyoma."},"publication_date":"2023-01-24","publication_name":{"en":"Magnetic Resonance in Medical Sciences","ja":"Magnetic Resonance in Medical Sciences"},"volume":"Vol.Online ahead of print","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2463/mrms.mp.2022-0067"],"issn":["1880-2206"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/118205","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/37164730","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=398472","label":"url"}],"paper_title":{"en":"Histological and immunohistochemical analysis of epithelial cells in epidermoid cysts in intrapancreatic accessory spleen.","ja":"Histological and immunohistochemical analysis of epithelial cells in epidermoid cysts in intrapancreatic accessory spleen."},"authors":{"en":[{"name":"Sumida Satoshi"},{"name":"Shimizu Mayuko"},{"name":"Miyakami Yuko"},{"name":"Kakimoto Takumi"},{"name":"Kobayashi Tomoko"},{"name":"Saijo Yasuyo"},{"name":"Matsumoto Minoru"},{"name":"Ogawa Hirohisa"},{"name":"Oya Takeshi"},{"name":"Bando Yoshimi"},{"name":"Uehara Hisanori"},{"name":"Taira Shu"},{"name":"Shimada Mitsuo"},{"name":"Tsuneyama Koichi"}],"ja":[{"name":"住田 智志"},{"name":"清水 真祐子"},{"name":"宮上 侑子"},{"name":"柿本 拓海"},{"name":"小林 智子"},{"name":"西條 康代"},{"name":"松本 穣"},{"name":"小川 博久"},{"name":"尾矢 剛志"},{"name":"坂東 良美"},{"name":"上原 久典"},{"name":"Taira Shu"},{"name":"島田 光生"},{"name":"常山 幸一"}]},"description":{"en":"Novel histological features of epithelial cells of ECIPAS were indicated. Although more cases need to be evaluated, we propose that the cause of ECIPAS may be different from that of pancreatic ductal origin. J. Med. Invest. 70 : 251-259, February, 2023.","ja":"Novel histological features of epithelial cells of ECIPAS were indicated. Although more cases need to be evaluated, we propose that the cause of ECIPAS may be different from that of pancreatic ductal origin. J. Med. Invest. 70 : 251-259, February, 2023."},"publication_date":"2023","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.70","number":"No.1.2","starting_page":"251","ending_page":"259","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.70.251"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/118239","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/36425390","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85142414132&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=397194","label":"url"}],"paper_title":{"en":"Imaging features of a myoepithelial carcinoma of the nasal cavity: A case report and literature review","ja":"Imaging features of a myoepithelial carcinoma of the nasal cavity: A case report and literature review"},"authors":{"en":[{"name":"Shinya Takayoshi"},{"name":"MATSUSHITA Tomoki"},{"name":"HIROSHIMA Yuka"},{"name":"Otomi Youichi"},{"name":"Kanematsu Yasuhisa"},{"name":"Bando Yoshimi"},{"name":"Uehara Hisanori"},{"name":"Kitamura Yoshiaki"},{"name":"Harada Masafumi"}],"ja":[{"name":"新家 崇義"},{"name":"松下 知樹"},{"name":"廣島 由"},{"name":"音見 暢一"},{"name":"兼松 康久"},{"name":"坂東 良美"},{"name":"上原 久典"},{"name":"北村 嘉章"},{"name":"原田 雅史"}]},"description":{"en":"Myoepithelial carcinoma of the nasal cavity is extremely rare. We report the case of a 66-year-old man with myoepithelial carcinoma of the nasal cavity. Computed tomography (CT) and magnetic resonance imaging revealed a lobulated soft tissue mass with central necrosis and hemorrhage, as well as an invasion of the skull base and left orbit. The patient presented with continuous nasal congestion and heavy head and had no elevated level of squamous cell carcinoma-related antigen. CT, magnetic resonance imaging, or F-fluorodeoxyglucose (FDG) positron emission tomography/CT revealed no evidence of a metastatic lesion. F-FDG accumulation in the tumor was inhomogeneous and moderate. Histopathological examination of the resected specimen confirmed a well-circumscribed solid tumor with septa, a small area of hemorrhage, and necrosis. The subsequent diagnosis was a myoepithelial carcinoma of the left nasal cavity. This case shows that nasal myoepithelial carcinoma might appear as a well-defined lobulated mass with hemorrhagic necrosis and intense contrast enhancement in the solid component. We conjecture that hemorrhagic necrosis and intense enhancement values may be potential markers of nasal myoepithelial carcinoma.","ja":"Myoepithelial carcinoma of the nasal cavity is extremely rare. We report the case of a 66-year-old man with myoepithelial carcinoma of the nasal cavity. Computed tomography (CT) and magnetic resonance imaging revealed a lobulated soft tissue mass with central necrosis and hemorrhage, as well as an invasion of the skull base and left orbit. The patient presented with continuous nasal congestion and heavy head and had no elevated level of squamous cell carcinoma-related antigen. CT, magnetic resonance imaging, or F-fluorodeoxyglucose (FDG) positron emission tomography/CT revealed no evidence of a metastatic lesion. F-FDG accumulation in the tumor was inhomogeneous and moderate. Histopathological examination of the resected specimen confirmed a well-circumscribed solid tumor with septa, a small area of hemorrhage, and necrosis. The subsequent diagnosis was a myoepithelial carcinoma of the left nasal cavity. This case shows that nasal myoepithelial carcinoma might appear as a well-defined lobulated mass with hemorrhagic necrosis and intense contrast enhancement in the solid component. We conjecture that hemorrhagic necrosis and intense enhancement values may be potential markers of nasal myoepithelial carcinoma."},"publication_date":"2022-11-18","publication_name":{"en":"Radiology Case Reports","ja":"Radiology Case Reports"},"volume":"Vol.18","number":"No.1","starting_page":"386","ending_page":"391","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.radcr.2022.10.081"],"issn":["1930-0433"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/118921","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/36482942","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=395938","label":"url"}],"paper_title":{"en":"Combination chemotherapy of doxorubicin and ifosfamide with proton beam therapy for myoepithelial carcinoma originating in the paraspinal region: A case report and literature review.","ja":"Combination chemotherapy of doxorubicin and ifosfamide with proton beam therapy for myoepithelial carcinoma originating in the paraspinal region: A case report and literature review."},"authors":{"en":[{"name":"Toki Shun-ichi"},{"name":"Nishisho Toshihiko"},{"name":"Miyagi Ryo"},{"name":"Bando Yoshimi"},{"name":"Sakaki Mika"},{"name":"Demizu Yusuke"},{"name":"Okimoto Tomoaki"},{"name":"Sairyo Koichi"}],"ja":[{"name":"土岐 俊一"},{"name":"西庄 俊彦"},{"name":"宮城 亮"},{"name":"坂東 良美"},{"name":"Sakaki Mika"},{"name":"Demizu Yusuke"},{"name":"Okimoto Tomoaki"},{"name":"西良 浩一"}]},"description":{"en":"Soft tissue myoepithelial carcinoma (MEC) is an extremely rare mesenchymal tumor that has a poor prognosis unless complete surgical resection is achieved. The present study reported a case of a 38-year-old woman with a tumor in the left paraspinal region at L2 to L3 with vertebral destruction. MEC was diagnosed based on molecular pathological examination of a biopsy specimen. Because curative surgery was expected to be difficult, a combination of chemotherapy with doxorubicin and ifosfamide and proton beam therapy as local therapy was performed, resulting in long-term survival for at least 7.8 years. To the best of our knowledge, this is the first case of soft tissue MEC for which classical cytotoxic chemotherapy and proton beam therapy were effective. Although surgical resection with negative margins is the mainstay of treatment for MEC, adequate doxorubicin-based systemic therapy and high-dose radiation therapy may be a feasible alternative in patients with unresectable or advanced MEC. Future studies on the relationship between molecular pathological features, including biomarkers, and the selection of therapeutic agents are warranted.","ja":"Soft tissue myoepithelial carcinoma (MEC) is an extremely rare mesenchymal tumor that has a poor prognosis unless complete surgical resection is achieved. The present study reported a case of a 38-year-old woman with a tumor in the left paraspinal region at L2 to L3 with vertebral destruction. MEC was diagnosed based on molecular pathological examination of a biopsy specimen. Because curative surgery was expected to be difficult, a combination of chemotherapy with doxorubicin and ifosfamide and proton beam therapy as local therapy was performed, resulting in long-term survival for at least 7.8 years. To the best of our knowledge, this is the first case of soft tissue MEC for which classical cytotoxic chemotherapy and proton beam therapy were effective. Although surgical resection with negative margins is the mainstay of treatment for MEC, adequate doxorubicin-based systemic therapy and high-dose radiation therapy may be a feasible alternative in patients with unresectable or advanced MEC. Future studies on the relationship between molecular pathological features, including biomarkers, and the selection of therapeutic agents are warranted."},"publication_date":"2022-11-03","publication_name":{"en":"Molecular and Clinical Oncology","ja":"Molecular and Clinical Oncology"},"volume":"Vol.17","number":"No.6","languages":["eng"],"referee":true,"identifiers":{"doi":["10.3892/mco.2022.2596"],"issn":["2049-9469"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://search.jamas.or.jp/link/ui/2023004968","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/36216544","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1390293710918867840/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=396016","label":"url"}],"paper_title":{"en":"Gastric cancer genome profiling reveals HER2 false-negative status and informs a successful trastuzumab treatment strategy","ja":"がん遺伝子パネル検査を契機にHER2陽性が判明しTrastuzumab投与により長期生存が得られた進行胃癌の1例."},"authors":{"en":[{"name":"wada hironori"},{"name":"Fujino Yasuteru"},{"name":"Kagemoto Kaizo"},{"name":"Kida Yoshifumi"},{"name":"Okada Yasuyuki"},{"name":"Mitsui Yasuhiro"},{"name":"Okamoto Koichi"},{"name":"Sato Yasushi"},{"name":"Bando Yoshimi"},{"name":"Miyamoto Hiroshi"},{"name":"Takayama Tetsuji"}],"ja":[{"name":"和田 浩典"},{"name":"藤野 泰輝"},{"name":"影本 開三"},{"name":"喜田 慶史"},{"name":"岡田 泰行"},{"name":"三井 康裕"},{"name":"岡本 耕一"},{"name":"佐藤 康史"},{"name":"坂東 良美"},{"name":"宮本 弘志"},{"name":"高山 哲治"}]},"description":{"en":"Intratumoral HER2 heterogeneity is a well-described gastric cancer feature and may explain many false-negative results related to this oncogene. An 81-year-old man was diagnosed at our hospital with stage IV gastric cancer with multiple lymph node metastases. Immunohistochemistry (IHC) analysis indicated that the primary tumor was HER2-negative. After a chemotherapy course, we submitted a pretreatment biopsy specimen for comprehensive cancer genome profiling (CGP) to determine the last-line therapy. This revealed HER2 amplification. The specimen was reevaluated using fluorescence in situ hybridization and IHC with deeper-cut specimens, which confirmed that the tumor was indeed HER2-positive. Therefore, the patient was treated with chemotherapy plus trastuzumab, which elicited tumor shrinkage and conferred long-term survival. Our current data underscore the CGP importance, which can provide more accurate tumor profilings and inform subsequent treatment decisions.","ja":"Intratumoral HER2 heterogeneity is a well-described gastric cancer feature and may explain many false-negative results related to this oncogene. An 81-year-old man was diagnosed at our hospital with stage IV gastric cancer with multiple lymph node metastases. Immunohistochemistry (IHC) analysis indicated that the primary tumor was HER2-negative. After a chemotherapy course, we submitted a pretreatment biopsy specimen for comprehensive cancer genome profiling (CGP) to determine the last-line therapy. This revealed HER2 amplification. The specimen was reevaluated using fluorescence in situ hybridization and IHC with deeper-cut specimens, which confirmed that the tumor was indeed HER2-positive. Therefore, the patient was treated with chemotherapy plus trastuzumab, which elicited tumor shrinkage and conferred long-term survival. Our current data underscore the CGP importance, which can provide more accurate tumor profilings and inform subsequent treatment decisions."},"publication_date":"2022-10-10","publication_name":{"en":"The Japanese Journal of Gastro-enterology","ja":"日本消化器病学会雑誌"},"volume":"Vol.119","number":"No.10","starting_page":"937","ending_page":"945","languages":["jpn"],"referee":true,"identifiers":{"doi":["10.11405/nisshoshi.119.937"],"issn":["0446-6586"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/118569","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/36162917","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=396697","label":"url"}],"paper_title":{"en":"Nationwide retrospective observational study of idiopathic dendriform pulmonary ossification: clinical features with a progressive phenotype.","ja":"Nationwide retrospective observational study of idiopathic dendriform pulmonary ossification: clinical features with a progressive phenotype."},"authors":{"en":[{"name":"Nishioka Yasuhiko"},{"name":"Toyoda Yuko"},{"name":"Egashira Ryoko"},{"name":"Johkoh Takeshi"},{"name":"Terasaki Yasuhiro"},{"name":"Hebisawa Akira"},{"name":"Abe Kinya"},{"name":"Baba Tomohisa"},{"name":"Fujikura Yuji"},{"name":"Fujita Etsuo"},{"name":"Hamada Naoki"},{"name":"Handa Tomohiro"},{"name":"Hasegawa Yoshinori"},{"name":"Hidaka Koko"},{"name":"Hisada Takeshi"},{"name":"Hisata Shu"},{"name":"Honjo Chisato"},{"name":"Ichikado Kazuya"},{"name":"Inoue Yoshikazu"},{"name":"Izumi Shinyu"},{"name":"Kato Motoyasu"},{"name":"Kishimoto Takumi"},{"name":"Okamoto Masaki"},{"name":"Miki Keisuke"},{"name":"Mineshita Masamichi"},{"name":"Nakamura Yutaro"},{"name":"Sakamoto Susumu"},{"name":"Sano Masaaki"},{"name":"Tsukada Yoshikazu"},{"name":"Yamasue Mari"},{"name":"Bando Yoshimi"},{"name":"Homma Sakae"},{"name":"Hagiwara Koichi"},{"name":"Suda Takafumi"},{"name":"Inase Naohiko"}],"ja":[{"name":"西岡 安彦"},{"name":"豊田 優子"},{"name":"Egashira Ryoko"},{"name":"Johkoh Takeshi"},{"name":"Terasaki Yasuhiro"},{"name":"Hebisawa Akira"},{"name":"Abe Kinya"},{"name":"Baba Tomohisa"},{"name":"Fujikura Yuji"},{"name":"Fujita Etsuo"},{"name":"Hamada Naoki"},{"name":"Handa Tomohiro"},{"name":"Hasegawa Yoshinori"},{"name":"Hidaka Koko"},{"name":"Hisada Takeshi"},{"name":"Hisata Shu"},{"name":"Honjo Chisato"},{"name":"Ichikado Kazuya"},{"name":"Inoue Yoshikazu"},{"name":"Izumi Shinyu"},{"name":"Kato Motoyasu"},{"name":"Kishimoto Takumi"},{"name":"Okamoto Masaki"},{"name":"Miki Keisuke"},{"name":"Mineshita Masamichi"},{"name":"Nakamura Yutaro"},{"name":"Sakamoto Susumu"},{"name":"Sano Masaaki"},{"name":"Tsukada Yoshikazu"},{"name":"Yamasue Mari"},{"name":"坂東 良美"},{"name":"Homma Sakae"},{"name":"Hagiwara Koichi"},{"name":"Suda Takafumi"},{"name":"Inase Naohiko"}]},"description":{"en":"IDPO develops at a young age with gradually progressive phenotype. Further research and long-term (>20 years) follow-up are required to clarify the pathogenesis and clinical findings in IDPO.","ja":"Twenty-two cases of IDPO were identified. Most subjects (82%) were male, aged 22-56 years (mean (SD), 37.9 (9.1)) at diagnosis. Nearly 80% of the subjects were asymptomatic, and the condition was discovered during a medical check-up. However, 36% of the subjects showed a decline in forced vital capacity (%FVC) predicted <80% at diagnosis. The typical radiological features of high-resolution CT (HRCT) are calcified branching structures that are predominantly distributed in the lower lung fields without any other conspicuous finding. Histopathological analysis also showed dendriform ossified lesions from the intraluminal areas to interstitial areas. Notably, during the follow-up period of 20 years, disease progression was found in 88% on HRCT and more than 50% on pulmonary function tests (FVC and/or forced expiratory volume in 1 s). Two cases with rapid decline of 10% /year in %FVC predicted were observed.)) at diagnosis. Nearly 80% of the subjects were asymptomatic, and the condition was discovered during a medical check-up. However, 36% of the subjects showed a decline in forced vital capacity (%FVC) predicted <80% at diagnosis. The typical radiological features of high-resolution CT (HRCT) are calcified branching structures that are predominantly distributed in the lower lung fields without any other conspicuous finding. Histopathological analysis also showed dendriform ossified lesions from the intraluminal areas to interstitial areas. Notably, during the follow-up period of 20 years, disease progression was found in 88% on HRCT and more than 50% on pulmonary function tests (FVC and/or forced expiratory volume in 1 s). Two cases with rapid decline of 10% /year in %FVC predicted were observed."},"publication_date":"2022-09","publication_name":{"en":"BMJ Open Respiratory Research","ja":"BMJ Open Respiratory Research"},"volume":"Vol.9","number":"No.1","starting_page":"e001337","ending_page":"e001337","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1136/bmjresp-2022-001337"],"issn":["2052-4439"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/35868869","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=387071","label":"url"}],"paper_title":{"en":"Magnetic resonance imaging characteristics of polypoid endometriosis and review of the literature.","ja":"Magnetic resonance imaging characteristics of polypoid endometriosis and review of the literature."},"authors":{"en":[{"name":"Takeuchi Mayumi"},{"name":"Matsuzaki Kenji"},{"name":"Bando Yoshimi"},{"name":"Harada Masafumi"}],"ja":[{"name":"竹内 麻由美"},{"name":"松崎 健司"},{"name":"坂東 良美"},{"name":"原田 雅史"}]},"description":{"en":"Polypoid endometriosis is a rare variant of endometriosis and may mimic malignancy. The purpose of this study is to evaluate magnetic resonance (MR) imaging characteristics of polypoid endometriosis for the differential diagnosis with malignancy. MR imaging findings of four histologically proven polypoid endometriosis were retrospectively evaluated with the review of the literature. All polypoid endometriosis exhibited high signal intensity on T2-weighted images reflecting abundant dilated endometrial glands. Peritoneal lesions were surrounded by low signal intensity rim represented the \"black rim sign\" reflecting endometriotic fibrous adhesion. Two cases arising from endometriotic cysts showed transmural extension (peritoneal extension and myometrial infiltration). Endometriotic hemorrhagic foci were demonstrated in four lesions as high signal intensity on T1-weighted images and/or susceptibility-induced signal voids on susceptibility-weighted MR sequence. Diffusion-weighted images showed high signal intensity with relatively high apparent diffusion coefficient (ADC) due to T2 shine-through effect but no diffusion restriction, and dynamic contrast-enhanced (DCE) MR imaging showed gradually increasing contrast-enhancement pattern like benign pathologies. Polypoid endometriosis may mimic malignancy; however, black rim sign may be a characteristic MR imaging finding for the peritoneal lesions, and no diffusion restriction and gradually increasing contrast-enhancement pattern may reflect its benign nature.","ja":"Polypoid endometriosis is a rare variant of endometriosis and may mimic malignancy. The purpose of this study is to evaluate magnetic resonance (MR) imaging characteristics of polypoid endometriosis for the differential diagnosis with malignancy. MR imaging findings of four histologically proven polypoid endometriosis were retrospectively evaluated with the review of the literature. All polypoid endometriosis exhibited high signal intensity on T2-weighted images reflecting abundant dilated endometrial glands. Peritoneal lesions were surrounded by low signal intensity rim represented the \"black rim sign\" reflecting endometriotic fibrous adhesion. Two cases arising from endometriotic cysts showed transmural extension (peritoneal extension and myometrial infiltration). Endometriotic hemorrhagic foci were demonstrated in four lesions as high signal intensity on T1-weighted images and/or susceptibility-induced signal voids on susceptibility-weighted MR sequence. Diffusion-weighted images showed high signal intensity with relatively high apparent diffusion coefficient (ADC) due to T2 shine-through effect but no diffusion restriction, and dynamic contrast-enhanced (DCE) MR imaging showed gradually increasing contrast-enhancement pattern like benign pathologies. Polypoid endometriosis may mimic malignancy; however, black rim sign may be a characteristic MR imaging finding for the peritoneal lesions, and no diffusion restriction and gradually increasing contrast-enhancement pattern may reflect its benign nature."},"publication_date":"2022-07-22","publication_name":{"en":"The Journal of Obstetrics and Gynaecology Research","ja":"The Journal of Obstetrics and Gynaecology Research"},"volume":"Vol.48","number":"No.10","starting_page":"2583","ending_page":"2593","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1111/jog.15367"],"issn":["1447-0756"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/118012","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/34670901","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=382775","label":"url"}],"paper_title":{"en":"Pulmonary Tumor Thrombotic Microangiopathy Due to Gastric Cancer Diagnosed Antemortem by a Cytological Examination of Aspirated Pulmonary Artery Blood.","ja":"Pulmonary Tumor Thrombotic Microangiopathy Due to Gastric Cancer Diagnosed Antemortem by a Cytological Examination of Aspirated Pulmonary Artery Blood."},"authors":{"en":[{"name":"Mitsui Yasuhiro"},{"name":"Yagi Mai"},{"name":"Muraki Sho"},{"name":"Matsuura Tomomi"},{"name":"Bando Yoshimi"},{"name":"Fujimoto Shota"},{"name":"Kitamura Shinji"},{"name":"Okamoto Koichi"},{"name":"Muguruma Naoki"},{"name":"Sata Masataka"},{"name":"Takayama Tetsuji"}],"ja":[{"name":"三井 康裕"},{"name":"Yagi Mai"},{"name":"村木 翔"},{"name":"松浦 朋美"},{"name":"坂東 良美"},{"name":"藤本 将太"},{"name":"北村 晋志"},{"name":"岡本 耕一"},{"name":"六車 直樹"},{"name":"佐田 政隆"},{"name":"高山 哲治"}]},"publication_date":"2022-05-15","publication_name":{"en":"Internal Medicine","ja":"Internal Medicine"},"volume":"Vol.61","number":"No.10","starting_page":"1491","ending_page":"1495","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2169/internalmedicine.8313-21"],"issn":["0918-2918"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=400276","label":"url"}],"paper_title":{"en":"Dynamic contrast-enhanced magnetic resonance imaging of endometrial cancer with/without squamous differentiation","ja":"Dynamic contrast-enhanced magnetic resonance imaging of endometrial cancer with/without squamous differentiation"},"authors":{"en":[{"name":"Takeuchi Mayumi"},{"name":"Matsuzaki Kenji"},{"name":"Bando Yoshimi"},{"name":"Harada Masafumi"}],"ja":[{"name":"竹内 麻由美"},{"name":"松崎 健司"},{"name":"坂東 良美"},{"name":"原田 雅史"}]},"publication_date":"2022-05-07","publication_name":{"en":"Proc. Intl. Soc. Mag. Reson. Med.","ja":"Proc. Intl. Soc. Mag. Reson. Med."},"starting_page":"4233","ending_page":"4233","languages":["eng"],"referee":true,"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/117152","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/35106660","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=384284","label":"url"}],"paper_title":{"en":"Cancer risk and genotype-phenotype correlation in Japanese patients with Cowden syndrome.","ja":"Cancer risk and genotype-phenotype correlation in Japanese patients with Cowden syndrome."},"authors":{"en":[{"name":"Teramae Satoshi"},{"name":"Muguruma Naoki"},{"name":"Okamoto Koichi"},{"name":"Oseto Kumiko"},{"name":"Nishikawa Ryutaro"},{"name":"Tanoue Takayuki"},{"name":"Hirata Keiji"},{"name":"Yanai Shunichi"},{"name":"Matsumoto Takayuki"},{"name":"Shimizu Seiji"},{"name":"Miwa Jun"},{"name":"Sakaki Yu"},{"name":"Yashima Kazuo"},{"name":"Ohnuma Hiroyuki"},{"name":"Sato Yasushi"},{"name":"Kitayama Yoshitaka"},{"name":"Ohda Yoshio"},{"name":"Yamauchi Atsushi"},{"name":"Sanomura Yoji"},{"name":"Tanaka Kumiko"},{"name":"Kubo Yoshiaki"},{"name":"Ishikawa Hideki"},{"name":"Bando Yoshimi"},{"name":"Sonoda TOmoko"},{"name":"Takayama Tetsuji"}],"ja":[{"name":"寺前 智史"},{"name":"六車 直樹"},{"name":"岡本 耕一"},{"name":"Oseto Kumiko"},{"name":"Nishikawa Ryutaro"},{"name":"Tanoue Takayuki"},{"name":"Hirata Keiji"},{"name":"Yanai Shunichi"},{"name":"Matsumoto Takayuki"},{"name":"Shimizu Seiji"},{"name":"Miwa Jun"},{"name":"Sakaki Yu"},{"name":"Yashima Kazuo"},{"name":"Ohnuma Hiroyuki"},{"name":"佐藤 康史"},{"name":"Kitayama Yoshitaka"},{"name":"Ohda Yoshio"},{"name":"Yamauchi Atsushi"},{"name":"Sanomura Yoji"},{"name":"田中 久美子"},{"name":"久保 宜明"},{"name":"Ishikawa Hideki"},{"name":"坂東 良美"},{"name":"Sonoda TOmoko"},{"name":"高山 哲治"}]},"description":{"en":"Cowden syndrome (CS) is an autosomal-dominant hereditary disorder caused by a germline PTEN variant and characterized by multiple hamartomas and a high risk of cancers. However, no detailed data on CS in Asian patients nor genotype-phenotype correlation have been reported. We performed the first Japanese nationwide questionnaire survey on CS and obtained questionnaire response data on 49 CS patients. Patients included 26 females (median age 48 years). The incidence of breast, thyroid, endometrium, and colorectal cancer was 32.7%, 12.2%, 19.2% (among females), and 6.1%, respectively. The incidence of any cancers was relatively high among all patients (46.9%, 23/49), and particularly female patients (73.1%, 19/26), compared with previous reports from Western countries. Gastrointestinal (GI) polyps were more frequently found throughout the GI tract compared with previous studies. PTEN variants were detected in 95.6% (22/23) of patients; 12 in the N-terminal region (11 in phosphatase domain) and 10 in the C-terminal (C2 domain) region. The incidence of cancer in the C2 domain group was significantly higher than in the N-terminal region (phosphatase) group. All female patients with C2 domain variant had breast cancer. Our data suggest that Japanese patients with CS, particularly female patients and patients with C2 domain variant may have a high risk of cancers.","ja":"Cowden syndrome (CS) is an autosomal-dominant hereditary disorder caused by a germline PTEN variant and characterized by multiple hamartomas and a high risk of cancers. However, no detailed data on CS in Asian patients nor genotype-phenotype correlation have been reported. We performed the first Japanese nationwide questionnaire survey on CS and obtained questionnaire response data on 49 CS patients. Patients included 26 females (median age 48 years). The incidence of breast, thyroid, endometrium, and colorectal cancer was 32.7%, 12.2%, 19.2% (among females), and 6.1%, respectively. The incidence of any cancers was relatively high among all patients (46.9%, 23/49), and particularly female patients (73.1%, 19/26), compared with previous reports from Western countries. Gastrointestinal (GI) polyps were more frequently found throughout the GI tract compared with previous studies. PTEN variants were detected in 95.6% (22/23) of patients; 12 in the N-terminal region (11 in phosphatase domain) and 10 in the C-terminal (C2 domain) region. The incidence of cancer in the C2 domain group was significantly higher than in the N-terminal region (phosphatase) group. All female patients with C2 domain variant had breast cancer. Our data suggest that Japanese patients with CS, particularly female patients and patients with C2 domain variant may have a high risk of cancers."},"publication_date":"2022-02-02","publication_name":{"en":"International Journal of Clinical Oncology","ja":"International Journal of Clinical Oncology"},"volume":"Vol.27","number":"No.4","starting_page":"639","ending_page":"647","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s10147-022-02116-w"],"issn":["1437-7772"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/117392","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/35064748","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=387288","label":"url"}],"paper_title":{"en":"Radiation therapy induces an abscopal effect and upregulates programmed death-ligand 1 expression in a patient with non-small cell lung cancer.","ja":"Radiation therapy induces an abscopal effect and upregulates programmed death-ligand 1 expression in a patient with non-small cell lung cancer."},"authors":{"en":[{"name":"Morita Yutaka"},{"name":"Saijo Atsuro"},{"name":"Nokihara Hiroshi"},{"name":"Mitsuhashi Atsushi"},{"name":"Yoneda Hiroto"},{"name":"Otsuka Kenji"},{"name":"Ogino Hirokazu"},{"name":"Bando Yoshimi"},{"name":"Nishioka Yasuhiko"}],"ja":[{"name":"Morita Yutaka"},{"name":"西條 敦郎"},{"name":"軒原 浩"},{"name":"三橋 惇志"},{"name":"米田 浩人"},{"name":"大塚 憲司"},{"name":"荻野 広和"},{"name":"坂東 良美"},{"name":"西岡 安彦"}]},"description":{"en":"T cells, occasionally resulting in a systemic immune response to the tumor outside of the treatment field. The phenomenon of tumor regression at the site distant from irradiated fields is known as the abscopal effect. Several case reports have indicated a potential role of RT in overcoming primary and acquired resistance against immune checkpoint inhibitors in non-small cell lung cancer (NSCLC) and melanoma patients. We herein report an NSCLC patient who developed acquired resistance to an RT-induced abscopal effect and subsequently experienced reactivation of the systemic antitumor immune response by pembrolizumab, an antiprogrammed death 1 antibody. In this case, RT not only induced an abscopal effect but also upregulated the programmed death-ligand 1 expression outside of the irradiated field when the patient developed resistance to the abscopal effect. This case can facilitate our understanding of the mechanism underlying the RT-induced systemic immune response against cancer cells and adaptive resistance mechanism of cancer cells from immune surveillance. These findings highlight the promising results of current clinical trials combining RT and immune checkpoint inhibitors. Ongoing clinical trials will further establish evidence supporting combination therapy with RT and immune checkpoint inhibitors.","ja":"T cells, occasionally resulting in a systemic immune response to the tumor outside of the treatment field. The phenomenon of tumor regression at the site distant from irradiated fields is known as the abscopal effect. Several case reports have indicated a potential role of RT in overcoming primary and acquired resistance against immune checkpoint inhibitors in non-small cell lung cancer (NSCLC) and melanoma patients. We herein report an NSCLC patient who developed acquired resistance to an RT-induced abscopal effect and subsequently experienced reactivation of the systemic antitumor immune response by pembrolizumab, an antiprogrammed death 1 antibody. In this case, RT not only induced an abscopal effect but also upregulated the programmed death-ligand 1 expression outside of the irradiated field when the patient developed resistance to the abscopal effect. This case can facilitate our understanding of the mechanism underlying the RT-induced systemic immune response against cancer cells and adaptive resistance mechanism of cancer cells from immune surveillance. These findings highlight the promising results of current clinical trials combining RT and immune checkpoint inhibitors. Ongoing clinical trials will further establish evidence supporting combination therapy with RT and immune checkpoint inhibitors."},"publication_date":"2022-01-22","publication_name":{"en":"Thoracic Cancer","ja":"Thoracic Cancer"},"volume":"Vol.13","number":"No.7","starting_page":"1079","ending_page":"1082","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1111/1759-7714.14330"],"issn":["1759-7714"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/34969725","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=393671","label":"url"}],"paper_title":{"en":"ypN0 in Patients with Definitive cN-positive Status After Preoperative Treatment Is a Prognostic Factor in Esophageal Cancer","ja":"ypN0 in Patients with Definitive cN-positive Status After Preoperative Treatment Is a Prognostic Factor in Esophageal Cancer"},"authors":{"en":[{"name":"Yoshida Takahiro"},{"name":"Nishino Takeshi"},{"name":"Goto Masakazu"},{"name":"Inoue Seiya"},{"name":"Fujiwara Satoshi"},{"name":"Takizawa Hiromitsu"},{"name":"Tangoku Akira"},{"name":"Uehara Hisanori"},{"name":"Bando Yoshimi"}],"ja":[{"name":"吉田 卓弘"},{"name":"西野 豪志"},{"name":"後藤 正和"},{"name":"井上 聖也"},{"name":"藤原 聡史"},{"name":"滝沢 宏光"},{"name":"丹黒 章"},{"name":"上原 久典"},{"name":"坂東 良美"}]},"description":{"en":"Histopathological tumor regression grade is applied not to lymph nodes but primary tumors modified by preoperative treatments. This study focused on patients whose pathological examination at the time of surgery showed no residual tumor after chemo(radio)therapy in the primary lesion (ypT0) or lymph nodes (ypN0). A total of 87 patients with clinical stage II/III thoracic esophageal cancer underwent esophagectomy following preoperative treatments to evaluate significances between pathological response and clinical outcomes; 51 patients with clinically definitive lymph node metastasis (cN+) were analyzed as a subgroup. ypT0 rates were 20.7% and 23.5%, and ypN0 rates were 47.1% and 27.5% in the whole cohort and in the cN+ subgroup, respectively. Disease-free survival, from surgery to relapse or death, was significantly influenced by ypN status (p=0.035) but not by ypT status in the 51 patients with definitive cN+ disease. Preoperative chemoradiation was an independent favorable factor for achievement of ypN0 in the 51 patients (odds ratio=0.09; p=0.007). ypN status was a predictive factor for DFS in patients treated with docetaxel plus low-dose 5-fluorouracil and cisplatin combined chemotherapy, superior to ypT status, especially in patients with definitive cN+ disease.","ja":"Histopathological tumor regression grade is applied not to lymph nodes but primary tumors modified by preoperative treatments. This study focused on patients whose pathological examination at the time of surgery showed no residual tumor after chemo(radio)therapy in the primary lesion (ypT0) or lymph nodes (ypN0). A total of 87 patients with clinical stage II/III thoracic esophageal cancer underwent esophagectomy following preoperative treatments to evaluate significances between pathological response and clinical outcomes; 51 patients with clinically definitive lymph node metastasis (cN+) were analyzed as a subgroup. ypT0 rates were 20.7% and 23.5%, and ypN0 rates were 47.1% and 27.5% in the whole cohort and in the cN+ subgroup, respectively. Disease-free survival, from surgery to relapse or death, was significantly influenced by ypN status (p=0.035) but not by ypT status in the 51 patients with definitive cN+ disease. Preoperative chemoradiation was an independent favorable factor for achievement of ypN0 in the 51 patients (odds ratio=0.09; p=0.007). ypN status was a predictive factor for DFS in patients treated with docetaxel plus low-dose 5-fluorouracil and cisplatin combined chemotherapy, superior to ypT status, especially in patients with definitive cN+ disease."},"publication_date":"2022-01","publication_name":{"en":"Anticancer Research","ja":"Anticancer Research"},"volume":"Vol.42","number":"No.1","starting_page":"195","ending_page":"203","languages":["eng"],"referee":true,"identifiers":{"doi":["10.21873/anticanres.15473"],"issn":["1791-7530"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116979","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383448","label":"url"}],"paper_title":{"en":"Small Intestinal Involvement and Genotype-Phenotype Correlation in Familial Adenomatous Polyposis.","ja":"Small Intestinal Involvement and Genotype-Phenotype Correlation in Familial Adenomatous Polyposis."},"authors":{"en":[{"name":"Tanaka Kumiko"},{"name":"Sato Yasushi"},{"name":"Ishikawa Hideki"},{"name":"Muguruma Naoki"},{"name":"Teramae Satoshi"},{"name":"Takeuchi Yoji"},{"name":"Mitsui Yasuhiro"},{"name":"Okamoto Koichi"},{"name":"Miyamoto Hiroshi"},{"name":"Bando Yoshimi"},{"name":"Sonoda Tomoko"},{"name":"Omiya Naoki"},{"name":"Mutoh Michihiro"},{"name":"Takayama Tetsuji"}],"ja":[{"name":"田中 久美子"},{"name":"佐藤 康史"},{"name":"Ishikawa Hideki"},{"name":"六車 直樹"},{"name":"寺前 智史"},{"name":"Takeuchi Yoji"},{"name":"三井 康裕"},{"name":"岡本 耕一"},{"name":"宮本 弘志"},{"name":"坂東 良美"},{"name":"Sonoda Tomoko"},{"name":"Omiya Naoki"},{"name":"Mutoh Michihiro"},{"name":"高山 哲治"}]},"publication_date":"2022-01","publication_name":{"en":"Techniques and Innovations in Gastrointestinal Endoscopy","ja":"Techniques and Innovations in Gastrointestinal Endoscopy"},"volume":"Vol.24","number":"No.1","starting_page":"26","ending_page":"34","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.tige.2021.10.001"],"issn":["2590-0307"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/118013","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/34645765","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=387290","label":"url"}],"paper_title":{"en":"A Case of Radiation-associated Angiosarcoma Presenting as Massive Pleural Effusion.","ja":"A Case of Radiation-associated Angiosarcoma Presenting as Massive Pleural Effusion."},"authors":{"en":[{"name":"Ogino Hirokazu"},{"name":"Tobiume Makoto"},{"name":"Kagawa Kozo"},{"name":"Kawano Hiroshi"},{"name":"Sakaguchi Satoshi"},{"name":"Saijo Atsuro"},{"name":"Matsumoto Daisuke"},{"name":"Takizawa Hiromitsu"},{"name":"Morikawa Yuriko"},{"name":"Bando Yoshimi"},{"name":"Goto Hisatsugu"},{"name":"Nokihara Hiroshi"},{"name":"Nishioka Yasuhiko"}],"ja":[{"name":"荻野 広和"},{"name":"飛梅 亮"},{"name":"香川 耕造"},{"name":"河野 弘"},{"name":"坂口 暁"},{"name":"西條 敦郎"},{"name":"Matsumoto Daisuke"},{"name":"滝沢 宏光"},{"name":"Morikawa Yuriko"},{"name":"坂東 良美"},{"name":"後東 久嗣"},{"name":"軒原 浩"},{"name":"西岡 安彦"}]},"description":{"en":"A 67-year-old man was admitted to our hospital for massive pleural effusion. He had a history of mandibular gingival carcinoma treated with radiation therapy (RT). Based on the cytology findings of pleural effusion and a thoracoscopic pleural biopsy, we finally diagnosed him with radiation-associated angiosarcoma. Retrospective cell-block immunocytochemistry with pleural effusion also showed potential utility for the diagnosis. This case highlights the importance of considering the possibility of radiation-associated secondary cancer in patients with pleural effusion who have a history of RT.","ja":"A 67-year-old man was admitted to our hospital for massive pleural effusion. He had a history of mandibular gingival carcinoma treated with radiation therapy (RT). Based on the cytology findings of pleural effusion and a thoracoscopic pleural biopsy, we finally diagnosed him with radiation-associated angiosarcoma. Retrospective cell-block immunocytochemistry with pleural effusion also showed potential utility for the diagnosis. This case highlights the importance of considering the possibility of radiation-associated secondary cancer in patients with pleural effusion who have a history of RT."},"publication_date":"2021-10-12","publication_name":{"en":"Internal Medicine","ja":"Internal Medicine"},"volume":"Vol.61","number":"No.9","starting_page":"1393","ending_page":"1397","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2169/internalmedicine.8195-21"],"issn":["1349-7235"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116721","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/34720843","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85117511057&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=382916","label":"url"}],"paper_title":{"en":"Long-Term Survival due to Chemotherapy including Paclitaxel in a Patient with Metastatic Primary Splenic Angiosarcoma.","ja":"Long-Term Survival due to Chemotherapy including Paclitaxel in a Patient with Metastatic Primary Splenic Angiosarcoma."},"authors":{"en":[{"name":"Takehara Masanori"},{"name":"Miyamoto Hiroshi"},{"name":"Fujino Yasuteru"},{"name":"Tomonari Tetsu"},{"name":"Taniguchi Tatsuya"},{"name":"Kitamura Shinji"},{"name":"Okamoto Koichi"},{"name":"Sogabe Masahiro"},{"name":"Sato Yasushi"},{"name":"Muguruma Naoki"},{"name":"Bando Yoshimi"},{"name":"Takayama Tetsuji"}],"ja":[{"name":"武原 正典"},{"name":"宮本 弘志"},{"name":"藤野 泰輝"},{"name":"友成 哲"},{"name":"谷口 達哉"},{"name":"北村 晋志"},{"name":"岡本 耕一"},{"name":"曽我部 正弘"},{"name":"佐藤 康史"},{"name":"六車 直樹"},{"name":"坂東 良美"},{"name":"高山 哲治"}]},"description":{"en":"A primary splenic angiosarcoma is a rare type of soft tissue sarcoma and is associated with an extremely poor prognosis. In this study, we describe the case of a patient who was diagnosed with metastatic primary splenic angiosarcoma and survived for about 2 years. A 62-year-old female was referred to us for the treatment of splenic angiosarcoma with disseminated intravascular coagulation (DIC) and multiple liver and bone metastases. Paclitaxel therapy resulted in recovery from DIC and enabled her to continue sequential treatment through to sixth-line chemotherapy. We reviewed all splenic angiosarcoma case reports which were described as stage IV to date and compared with our case. From these data, we found that the median overall survival was 105 days, and the prognosis of splenic angiosarcoma of stage IV was worse than conventional case series. Splenectomy was performed in more patients than chemotherapy as a treatment. Moreover, various chemotherapeutic regimens were used. These data suggest that administering chemotherapy including paclitaxel to patients with splenic angiosarcoma might improve their prognosis.","ja":"A primary splenic angiosarcoma is a rare type of soft tissue sarcoma and is associated with an extremely poor prognosis. In this study, we describe the case of a patient who was diagnosed with metastatic primary splenic angiosarcoma and survived for about 2 years. A 62-year-old female was referred to us for the treatment of splenic angiosarcoma with disseminated intravascular coagulation (DIC) and multiple liver and bone metastases. Paclitaxel therapy resulted in recovery from DIC and enabled her to continue sequential treatment through to sixth-line chemotherapy. We reviewed all splenic angiosarcoma case reports which were described as stage IV to date and compared with our case. From these data, we found that the median overall survival was 105 days, and the prognosis of splenic angiosarcoma of stage IV was worse than conventional case series. Splenectomy was performed in more patients than chemotherapy as a treatment. Moreover, various chemotherapeutic regimens were used. These data suggest that administering chemotherapy including paclitaxel to patients with splenic angiosarcoma might improve their prognosis."},"publication_date":"2021-10-11","publication_name":{"en":"Case Reports in Gastroenterology","ja":"Case Reports in Gastroenterology"},"volume":"Vol.15","number":"No.3","starting_page":"910","ending_page":"918","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1159/000519211"],"issn":["1662-0631"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116931","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/34622010","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85114915216&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383565","label":"url"}],"paper_title":{"en":"Clinicopathological characteristics of early gastric cancer associated with autoimmune gastritis.","ja":"Clinicopathological characteristics of early gastric cancer associated with autoimmune gastritis."},"authors":{"en":[{"name":"Kitamura Shinji"},{"name":"Muguruma Naoki"},{"name":"Okamoto Koichi"},{"name":"Kagemoto Kaizo"},{"name":"Kida Yoshifumi"},{"name":"Mitsui Yasuhiro"},{"name":"Ueda Hiroyuki"},{"name":"Kawaguchi Tomoyuki"},{"name":"Miyamoto Hiroshi"},{"name":"Sato Yasushi"},{"name":"Aoki Rika"},{"name":"Shunto Joji"},{"name":"Bando Yoshimi"},{"name":"Takayama Tetsuji"}],"ja":[{"name":"北村 晋志"},{"name":"六車 直樹"},{"name":"岡本 耕一"},{"name":"影本 開三"},{"name":"喜田 慶史"},{"name":"三井 康裕"},{"name":"上田 浩之"},{"name":"川口 智之"},{"name":"宮本 弘志"},{"name":"佐藤 康史"},{"name":"Aoki Rika"},{"name":"Shunto Joji"},{"name":"坂東 良美"},{"name":"高山 哲治"}]},"publication_date":"2021-09-16","publication_name":{"en":"JGH Open","ja":"JGH Open"},"volume":"Vol.5","number":"No.10","starting_page":"1210","ending_page":"1215","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1002/jgh3.12656"],"issn":["2397-9070"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/34563448","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=403121","label":"url"}],"paper_title":{"en":"Reproducibility and prognostic significance of area of residual tumor (ART) in post-neoadjuvant resections of pancreatic ductal adenocarcinoma.","ja":"Reproducibility and prognostic significance of area of residual tumor (ART) in post-neoadjuvant resections of pancreatic ductal adenocarcinoma."},"authors":{"en":[{"name":"Kameyama Ai"},{"name":"Ye Juanjuan"},{"name":"Shimomura Ayaka"},{"name":"Yokohira Masanao"},{"name":"Nakano-Narusawa Yuko"},{"name":"Yamakawa Keiko"},{"name":"Mukai Yuri"},{"name":"Sanomura Takayuki"},{"name":"Okuyama Hiroyuki"},{"name":"Miyatake Nobuyuki"},{"name":"Furihata Mutsuo"},{"name":"Tanaka Chiharu"},{"name":"Kitazawa Riko"},{"name":"Bando Yoshimi"},{"name":"Suemitsu Yamato"},{"name":"Kojima Motohiro"},{"name":"Mino-Kenudson Mari"},{"name":"Suzuki Yasuyuki"},{"name":"Okano Keiichi"},{"name":"Matsuda Yoko"}],"ja":[{"name":"Kameyama Ai"},{"name":"Ye Juanjuan"},{"name":"Shimomura Ayaka"},{"name":"Yokohira Masanao"},{"name":"Nakano-Narusawa Yuko"},{"name":"Yamakawa Keiko"},{"name":"Mukai Yuri"},{"name":"Sanomura Takayuki"},{"name":"Okuyama Hiroyuki"},{"name":"Miyatake Nobuyuki"},{"name":"Furihata Mutsuo"},{"name":"Tanaka Chiharu"},{"name":"Kitazawa Riko"},{"name":"坂東 良美"},{"name":"Suemitsu Yamato"},{"name":"Kojima Motohiro"},{"name":"Mino-Kenudson Mari"},{"name":"Suzuki Yasuyuki"},{"name":"Okano Keiichi"},{"name":"Matsuda Yoko"}]},"description":{"en":"The ART grading system may be the most practical system to assess the tumor response in post-NACRT resections of PDAC.","ja":"The ART grading system may be the most practical system to assess the tumor response in post-NACRT resections of PDAC."},"publication_date":"2021-09-10","publication_name":{"en":"Pancreatology","ja":"Pancreatology"},"volume":"Vol.21","number":"No.8","starting_page":"1506","ending_page":"1515","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.pan.2021.09.006"],"issn":["1424-3911"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://search.jamas.or.jp/link/ui/2021334268","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1390007282525435264/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=396010","label":"url"}],"paper_title":{"en":"A CASE OF MULTIPLE COLONIC ULCERS CAUSED BY RHEUMATOID VASCULITIS","ja":"関節リウマチの経過中に発生したリウマトイド血管炎に起因する多発大腸潰瘍の1例."},"authors":{"en":[{"name":"Fujino Yasuteru"},{"name":"Tanaka Kumiko"},{"name":"Nakamura Fumika"},{"name":"Kida Yoshifumi"},{"name":"Hirao Akihiro"},{"name":"Okada Yasuyuki"},{"name":"Takehara Masanori"},{"name":"Fukuya Akira"},{"name":"Bando Yoshimi"},{"name":"Takayama Tetsuji"}],"ja":[{"name":"藤野 泰輝"},{"name":"田中 久美子"},{"name":"中村 文香"},{"name":"喜田 慶史"},{"name":"平尾 章博"},{"name":"岡田 泰行"},{"name":"武原 正典"},{"name":"福家 慧"},{"name":"坂東 良美"},{"name":"高山 哲治"}]},"publication_date":"2021-07-01","publication_name":{"en":"Gastroenterological Endoscopy","ja":"Gastroenterological Endoscopy"},"volume":"Vol.63","number":"No.7","starting_page":"1358","ending_page":"1364","languages":["jpn"],"referee":true,"identifiers":{"doi":["10.11280/gee.63.1358"],"issn":["0387-1207"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"http://repo.lib.tokushima-u.ac.jp/115993","label":"url"},{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/115993","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1390288060504040448/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=390585","label":"url"}],"paper_title":{"en":"Clinical application of dynamic 18F-fluorodeoxyglucose positron-emission tomography / computed tomography in the differential diagnoses of musculoskeletal lesions","ja":"Clinical application of dynamic 18F-fluorodeoxyglucose positron-emission tomography / computed tomography in the differential diagnoses of musculoskeletal lesions"},"authors":{"en":[{"name":"Shinya Takayoshi"},{"name":"Yoichi Otomi"},{"name":"Nishisho Toshihiko"},{"name":"Beuthien-Baumann B"},{"name":"Irahara Saho"},{"name":"Kubo Michiko"},{"name":"Otsuka Hideki"},{"name":"Bando Yoshimi"},{"name":"Sairyo Koichi"},{"name":"Harada Masafumi"}],"ja":[{"name":"新家 崇義"},{"name":"Yoichi Otomi"},{"name":"西庄 俊彦"},{"name":"Beuthien-Baumann B"},{"name":"苛原 早保"},{"name":"久保 典子"},{"name":"大塚 秀樹"},{"name":"坂東 良美"},{"name":"西良 浩一"},{"name":"原田 雅史"}]},"description":{"en":"
We aimed to assess the differential diagnostic efficacy of dynamic F-18 fluorodeoxyglucose (FDG) positron emission tomography / computed tomography (PET / CT) and to evaluate the appropriate scan timings for diagnosis of musculoskeletal lesions (MSLs). Dynamic scans (5-15 [phase 1], 15-25 [phase 2], and 25-35 [phase 3] min after F-18 FDG injection) and dual-time-point scans (1 and 2 h after injection) were acquired for 23 MSLs [4 benign MSLs (BMSLs). 10 primary malignant musculoskeletal tumors (PMMSTs), and 9 metastatic musculoskeletal tumors (MMSTs)]. We compared the maximum standardized uptake values (SUVmax) and corresponding retention indices for dynamic (RI-SUVdyn) and dual-time-point (RI-SUVdual) scans and evaluated diagnostic efficacy using receiver operating characteristic (ROC) curve analyses. The SUVmax gradually decreased or was almost identical with minimal fluctuation in 3 BMSLs and 1 PMMST. SUVmax increased over time after phase 2 in 18 malignant MSLs (MMSLs). There were significant differences in SUVmax (for all time phases) and RI-SUV dual between BMSLs and MMSLs and between PMMSTs and MMSTs. In the ROC analyses, the areas under the curve for SUV in phases 2 and 3 were highest for differentiating BMSLs from MMSLs and PMMSTs from MMSTs, respectively. Dynamic F-18 FDG PET / CT is valuable for diagnosis of musculoskeletal lesions. J. Med. Invest. 68 : 96-104, February, 2021
","ja":"We aimed to assess the differential diagnostic efficacy of dynamic F-18 fluorodeoxyglucose (FDG) positron emission tomography / computed tomography (PET / CT) and to evaluate the appropriate scan timings for diagnosis of musculoskeletal lesions (MSLs). Dynamic scans (5-15 [phase 1], 15-25 [phase 2], and 25-35 [phase 3] min after F-18 FDG injection) and dual-time-point scans (1 and 2 h after injection) were acquired for 23 MSLs [4 benign MSLs (BMSLs). 10 primary malignant musculoskeletal tumors (PMMSTs), and 9 metastatic musculoskeletal tumors (MMSTs)]. We compared the maximum standardized uptake values (SUVmax) and corresponding retention indices for dynamic (RI-SUVdyn) and dual-time-point (RI-SUVdual) scans and evaluated diagnostic efficacy using receiver operating characteristic (ROC) curve analyses. The SUVmax gradually decreased or was almost identical with minimal fluctuation in 3 BMSLs and 1 PMMST. SUVmax increased over time after phase 2 in 18 malignant MSLs (MMSLs). There were significant differences in SUVmax (for all time phases) and RI-SUV dual between BMSLs and MMSLs and between PMMSTs and MMSTs. In the ROC analyses, the areas under the curve for SUV in phases 2 and 3 were highest for differentiating BMSLs from MMSLs and PMMSTs from MMSTs, respectively. Dynamic F-18 FDG PET / CT is valuable for diagnosis of musculoskeletal lesions. J. Med. Invest. 68 : 96-104, February, 2021
"},"publication_date":"2021-02","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.68","number":"No.1. 2","starting_page":"96","ending_page":"104","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.68.96"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/115966","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/33395688","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85099095900&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=373131","label":"url"}],"paper_title":{"en":"S100P expression via DNA hypomethylation promotes cell growth in the sessile serrated adenoma/polyp-cancer sequence.","ja":"S100P expression via DNA hypomethylation promotes cell growth in the sessile serrated adenoma/polyp-cancer sequence."},"authors":{"en":[{"name":"Takahashi Sayo"},{"name":"Okamoto Koichi"},{"name":"Tanahashi Toshihito"},{"name":"Fujimoto Shota"},{"name":"Nakagawa Tadahiko"},{"name":"Bando Masahiro"},{"name":"ma beibei"},{"name":"Kawaguchi Tomoyuki"},{"name":"Fujino Yasuteru"},{"name":"Mitsui Yasuhiro"},{"name":"Kitamura Shinji"},{"name":"Miyamoto Hiroshi"},{"name":"Sato Yasushi"},{"name":"Muguruma Naoki"},{"name":"Bando Yoshimi"},{"name":"Sato Toshiro"},{"name":"Fujimori Takahiro"},{"name":"Takayama Tetsuji"}],"ja":[{"name":"高橋 早代"},{"name":"岡本 耕一"},{"name":"棚橋 俊仁"},{"name":"藤本 将太"},{"name":"中川 忠彦"},{"name":"板東 正浩"},{"name":"馬 貝貝"},{"name":"川口 智之"},{"name":"藤野 泰輝"},{"name":"三井 康裕"},{"name":"北村 晋志"},{"name":"宮本 弘志"},{"name":"佐藤 康史"},{"name":"六車 直樹"},{"name":"坂東 良美"},{"name":"Sato Toshiro"},{"name":"Fujimori Takahiro"},{"name":"高山 哲治"}]},"description":{"en":"Sessile serrated adenomas/polyps (SSA/Ps) are a putative precursor lesion of colon cancer. Although the relevance of DNA hypermethylation in the SSA/P-cancer sequence is well documented, the role of DNA hypomethylation is unknown. We investigated the biological relevance of DNA hypomethylation in the SSA/P-cancer sequence by using 3-dimensional organoids of SSA/P. We first analyzed hypomethylated genes using datasets from our previous DNA methylation array analysis on 7 SSA/P and 2 cancer in SSA/P specimens. Expression levels of hypomethylated genes in SSA/P specimens were determined by RT-PCR and immunohistochemistry. We established 3-dimensional SSA/P organoids and performed knockdown experiments using a lentiviral shRNA vector. DNA hypomethylation at CpG sites of the gene was quantitated by MassARRAY analysis. The mean number of hypomethylated genes in SSA/P and cancer in SSA/P was 41.6 ± 27.5 and 214 ± 19.8, respectively, showing a stepwise increment in hypomethylation during the SSA/P-cancer sequence. S100P, S100α2, PKP3, and MUC2 were most commonly hypomethylated in SSA/P specimens. The mRNA and protein expression levels of S100P, S100α2, and MUC2 were significantly elevated in SSA/P compared with normal colon tissues, as revealed by RT-PCR and immunohistochemistry, respectively. Among these, mRNA and protein levels were highest for S100P. Knockdown of the S100P gene using a lentiviral shRNA vector in 3-dimensional SSA/P organoids inhibited cell growth by >50% (p < 0.01). The mean diameter of SSA/P organoids with S100P gene knockdown was significantly smaller compared with control organoids. MassARRAY analysis of DNA hypomethylation in the S100P gene revealed significant hypomethylation at specific CpG sites in intron 1, exon 1, and the 5'-flanking promoter region. These results suggest that DNA hypomethylation, including S100P hypomethylation, is supposedly associated with the SSA/P-cancer sequence. S100P overexpression via DNA hypomethylation plays an important role in promoting cell growth in the SSA/P-cancer sequence.","ja":"Sessile serrated adenomas/polyps (SSA/Ps) are a putative precursor lesion of colon cancer. Although the relevance of DNA hypermethylation in the SSA/P-cancer sequence is well documented, the role of DNA hypomethylation is unknown. We investigated the biological relevance of DNA hypomethylation in the SSA/P-cancer sequence by using 3-dimensional organoids of SSA/P. We first analyzed hypomethylated genes using datasets from our previous DNA methylation array analysis on 7 SSA/P and 2 cancer in SSA/P specimens. Expression levels of hypomethylated genes in SSA/P specimens were determined by RT-PCR and immunohistochemistry. We established 3-dimensional SSA/P organoids and performed knockdown experiments using a lentiviral shRNA vector. DNA hypomethylation at CpG sites of the gene was quantitated by MassARRAY analysis. The mean number of hypomethylated genes in SSA/P and cancer in SSA/P was 41.6 ± 27.5 and 214 ± 19.8, respectively, showing a stepwise increment in hypomethylation during the SSA/P-cancer sequence. S100P, S100α2, PKP3, and MUC2 were most commonly hypomethylated in SSA/P specimens. The mRNA and protein expression levels of S100P, S100α2, and MUC2 were significantly elevated in SSA/P compared with normal colon tissues, as revealed by RT-PCR and immunohistochemistry, respectively. Among these, mRNA and protein levels were highest for S100P. Knockdown of the S100P gene using a lentiviral shRNA vector in 3-dimensional SSA/P organoids inhibited cell growth by >50% (p < 0.01). The mean diameter of SSA/P organoids with S100P gene knockdown was significantly smaller compared with control organoids. MassARRAY analysis of DNA hypomethylation in the S100P gene revealed significant hypomethylation at specific CpG sites in intron 1, exon 1, and the 5'-flanking promoter region. These results suggest that DNA hypomethylation, including S100P hypomethylation, is supposedly associated with the SSA/P-cancer sequence. S100P overexpression via DNA hypomethylation plays an important role in promoting cell growth in the SSA/P-cancer sequence."},"publication_date":"2021-01-04","publication_name":{"en":"Digestion","ja":"Digestion"},"volume":"Vol.102","number":"No.5","starting_page":"789","ending_page":"802","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1159/000512575"],"issn":["1421-9867"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116023","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/33994473","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=377722","label":"url"}],"paper_title":{"en":"A CASE OF VAGUS NERVE SCHWANNOMA DIFFICULT TO DISTINGUISH FROM LYMPH NODAL METASTASIS OF ESOPHAGEAL CANCER.","ja":"A CASE OF VAGUS NERVE SCHWANNOMA DIFFICULT TO DISTINGUISH FROM LYMPH NODAL METASTASIS OF ESOPHAGEAL CANCER."},"authors":{"en":[{"name":"Miyamoto Naoki"},{"name":"Inoue Seiya"},{"name":"Nishino Takeshi"},{"name":"Goto Masakazu"},{"name":"Yoshida Takahiro"},{"name":"Kobayashi Tomoko"},{"name":"Bando Yoshimi"},{"name":"Takizawa Hiromitsu"},{"name":"Tangoku Akira"}],"ja":[{"name":"宮本 直輝"},{"name":"井上 聖也"},{"name":"西野 豪志"},{"name":"後藤 正和"},{"name":"吉田 卓弘"},{"name":"小林 智子"},{"name":"坂東 良美"},{"name":"滝沢 宏光"},{"name":"丹黒 章"}]},"description":{"en":"In this report, we describe a rare case of vagus nerve schwannoma associated with esophageal cancer. A 70-year-old man visited our hospital complaining of worsening dysphagia. His upper gastrointenstinal endoscopy revealed a mass in the esophagus. A contrast-enhanced chest computed tomography also detected a 15 mm nodule attached to the tracheal membrane. This nodule was diagnosed as a metastatic lymph node. Although the primary tumor reduced after neoadjuvant chemotherapy, the nodule remained intact ; it showed fluorodeoxyglucose accumulation on positron emission tomography. We had a clinical diagnosis of stage III after neoadjuvant chemotherapy and underwent surgery. Intraoperatively, the nodule could not be detached from the right vagus nerve ; therefore, we excised the nodule along with the adjacent vagus nerve. The nodule was pathologically diagnosed as a vagus schwannoma. The nodule was not a regional lymph node metastasis of esophageal cancer. His postoperative course was uneventful, and he is currently undergoing outpatient follow-up without recurrence. J. Med. Invest. 68 : 205-208, February, 2021.","ja":"In this report, we describe a rare case of vagus nerve schwannoma associated with esophageal cancer. A 70-year-old man visited our hospital complaining of worsening dysphagia. His upper gastrointenstinal endoscopy revealed a mass in the esophagus. A contrast-enhanced chest computed tomography also detected a 15 mm nodule attached to the tracheal membrane. This nodule was diagnosed as a metastatic lymph node. Although the primary tumor reduced after neoadjuvant chemotherapy, the nodule remained intact ; it showed fluorodeoxyglucose accumulation on positron emission tomography. We had a clinical diagnosis of stage III after neoadjuvant chemotherapy and underwent surgery. Intraoperatively, the nodule could not be detached from the right vagus nerve ; therefore, we excised the nodule along with the adjacent vagus nerve. The nodule was pathologically diagnosed as a vagus schwannoma. The nodule was not a regional lymph node metastasis of esophageal cancer. His postoperative course was uneventful, and he is currently undergoing outpatient follow-up without recurrence. J. Med. Invest. 68 : 205-208, February, 2021."},"publication_date":"2021","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.68","number":"No.1.2","starting_page":"205","ending_page":"208","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.68.205"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/33021438","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=377443","label":"url"}],"paper_title":{"en":"Neuropsychiatric systemic lupus erythematosus with cerebellar vasculitis and obstructive hydrocephalus requiring decompressive craniectomy.","ja":"Neuropsychiatric systemic lupus erythematosus with cerebellar vasculitis and obstructive hydrocephalus requiring decompressive craniectomy."},"authors":{"en":[{"name":"Naito Nobuhito"},{"name":"Kawano Hiroshi"},{"name":"Yamashita Yuya"},{"name":"Kondou Mayo"},{"name":"Haji Shotaro"},{"name":"Miyamoto Ryosuke"},{"name":"Toyoda Yuko"},{"name":"Kanematsu Yasuhisa"},{"name":"Izumi Yuishin"},{"name":"Bando Yoshimi"},{"name":"Nishioka Yasuhiko"}],"ja":[{"name":"内藤 伸仁"},{"name":"河野 弘"},{"name":"山下 雄也"},{"name":"近藤 真代"},{"name":"土師 正太郎"},{"name":"宮本 亮介"},{"name":"豊田 優子"},{"name":"兼松 康久"},{"name":"和泉 唯信"},{"name":"坂東 良美"},{"name":"西岡 安彦"}]},"description":{"en":"A 36-year-old woman who had been diagnosed with systemic lupus erythematosus (SLE) was admitted to our hospital due to increasing disease SLE activity. Despite the intensification of immunosuppressive treatment, headache newly developed and worsened. Magnetic resonance imaging (MRI) revealed spreading of a high-intensity area along the sulci of the bilateral cerebellar hemispheres. She was diagnosed with neuropsychiatric SLE and methylprednisolone (mPSL) pulse therapy was started. However, consciousness disorder due to cerebellar oedema with obstructive hydrocephalus appeared and required decompressive craniectomy. The histological findings of the biopsy specimens from cerebellar vermis were compatible with features of vasculitis. She was successfully treated adding intravenous cyclophosphamide therapy.","ja":"A 36-year-old woman who had been diagnosed with systemic lupus erythematosus (SLE) was admitted to our hospital due to increasing disease SLE activity. Despite the intensification of immunosuppressive treatment, headache newly developed and worsened. Magnetic resonance imaging (MRI) revealed spreading of a high-intensity area along the sulci of the bilateral cerebellar hemispheres. She was diagnosed with neuropsychiatric SLE and methylprednisolone (mPSL) pulse therapy was started. However, consciousness disorder due to cerebellar oedema with obstructive hydrocephalus appeared and required decompressive craniectomy. The histological findings of the biopsy specimens from cerebellar vermis were compatible with features of vasculitis. She was successfully treated adding intravenous cyclophosphamide therapy."},"publication_date":"2020-10-09","publication_name":{"en":"Modern Rheumatology Case Reports","ja":"Modern Rheumatology Case Reports"},"volume":"Vol.5","number":"No.1","starting_page":"52","ending_page":"57","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1080/24725625.2020.1826626"],"issn":["2472-5625"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116240","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/33080748","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=371855","label":"url"}],"paper_title":{"en":"Conversion therapy for unresectable hepatocellular carcinoma after lenvatinib Three case reports.","ja":"Conversion therapy for unresectable hepatocellular carcinoma after lenvatinib Three case reports."},"authors":{"en":[{"name":"Tomonari Tetsu"},{"name":"Sato Yasushi"},{"name":"Tanaka Hironori"},{"name":"Tanaka Takahiro"},{"name":"Taniguchi Tatsuya"},{"name":"Sogabe Masahiro"},{"name":"Okamoto Koichi"},{"name":"Miyamoto Hiroshi"},{"name":"Muguruma Naoki"},{"name":"Saitou Yu"},{"name":"Imura Satoru"},{"name":"Bando Yoshimi"},{"name":"Shimada Mitsuo"},{"name":"Takayama Tetsuji"}],"ja":[{"name":"友成 哲"},{"name":"佐藤 康史"},{"name":"田中 宏典"},{"name":"田中 貴大"},{"name":"谷口 達哉"},{"name":"曽我部 正弘"},{"name":"岡本 耕一"},{"name":"宮本 弘志"},{"name":"六車 直樹"},{"name":"齋藤 裕"},{"name":"居村 暁"},{"name":"坂東 良美"},{"name":"島田 光生"},{"name":"高山 哲治"}]},"description":{"en":"Lenvatinib (LEN) is a novel potent multi-tyrosine kinase inhibitor, approved as first-line treatment for unresectable hepatocellular carcinoma (HCC). Considering its high objective response rate, LEN therapy could be expected to achieve downstaging of tumors and lead to conversion therapy with hepatectomy or ablation. However, the feasibility of conversion therapy after LEN treatment in unresectable HCC remains largely unknown. Here, we reported 3 cases of unresectable HCC: case 1, a 69-year-old man diagnosed with ruptured HCC; case 2, a 72-year-old woman with nonalcoholic steatohepatitis-based HCC; and case 3, a 73-year-old man with a history of alcoholic cirrhosis-based HCC. In all cases, cirrhosis was classified as Child-Pugh 5 and modified albumin-bilirubin grade 1 or 2a. HCC was diagnosed as Barcelona Clinic Liver Cancer (BCLC) stage B. In all cases, LEN was initiated after conventional-transcatheter arterial embolization enforcement, while maintaining liver function. In all cases, the main tumor size decreased after 6 months of LEN treatment and no satellite nodes were detected, indicating downstaging of HCC to BCLC stage A. Subsequently, conversion hepatectomy or ablation was performed. After successful conversion therapy, the general condition of the patients was good, without tumor recurrence during the observation period (median 10 months). This study demonstrated that LEN enables downstaging of HCC and thus represents a bridge to successful surgery or ablation therapy. In particular, LEN treatment may facilitate the possibility for conversion therapy of initially unresectable HCC, while maintaining the hepatic functional reserve.","ja":"Lenvatinib (LEN) is a novel potent multi-tyrosine kinase inhibitor, approved as first-line treatment for unresectable hepatocellular carcinoma (HCC). Considering its high objective response rate, LEN therapy could be expected to achieve downstaging of tumors and lead to conversion therapy with hepatectomy or ablation. However, the feasibility of conversion therapy after LEN treatment in unresectable HCC remains largely unknown. Here, we reported 3 cases of unresectable HCC: case 1, a 69-year-old man diagnosed with ruptured HCC; case 2, a 72-year-old woman with nonalcoholic steatohepatitis-based HCC; and case 3, a 73-year-old man with a history of alcoholic cirrhosis-based HCC. In all cases, cirrhosis was classified as Child-Pugh 5 and modified albumin-bilirubin grade 1 or 2a. HCC was diagnosed as Barcelona Clinic Liver Cancer (BCLC) stage B. In all cases, LEN was initiated after conventional-transcatheter arterial embolization enforcement, while maintaining liver function. In all cases, the main tumor size decreased after 6 months of LEN treatment and no satellite nodes were detected, indicating downstaging of HCC to BCLC stage A. Subsequently, conversion hepatectomy or ablation was performed. After successful conversion therapy, the general condition of the patients was good, without tumor recurrence during the observation period (median 10 months). This study demonstrated that LEN enables downstaging of HCC and thus represents a bridge to successful surgery or ablation therapy. In particular, LEN treatment may facilitate the possibility for conversion therapy of initially unresectable HCC, while maintaining the hepatic functional reserve."},"publication_date":"2020-09-18","publication_name":{"en":"Medicine","ja":"Medicine"},"volume":"Vol.99","number":"No.42","starting_page":"e22782","ending_page":"e22782","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1097/MD.0000000000022782"],"issn":["0025-7974"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116522","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/34191157","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85100671212&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=378077","label":"url"}],"paper_title":{"en":"Preliminary clinical assessment of dynamic carbon-11 methionine positron-emission tomography/computed tomography for the diagnosis of the pathologies in patients with musculoskeletal lesions: a prospective study.","ja":"Preliminary clinical assessment of dynamic carbon-11 methionine positron-emission tomography/computed tomography for the diagnosis of the pathologies in patients with musculoskeletal lesions: a prospective study."},"authors":{"en":[{"name":"Shinya Takayoshi"},{"name":"Otomi Youichi"},{"name":"Nishisho Toshihiko"},{"name":"Beuthien-Baumann Bettina"},{"name":"Kubo Michiko"},{"name":"Otsuka Hideki"},{"name":"Bando Yoshimi"},{"name":"Yanagawa Hiroaki"},{"name":"Sairyo Koichi"},{"name":"Harada Masafumi"}],"ja":[{"name":"新家 崇義"},{"name":"音見 暢一"},{"name":"西庄 俊彦"},{"name":"Beuthien-Baumann Bettina"},{"name":"久保 典子"},{"name":"大塚 秀樹"},{"name":"坂東 良美"},{"name":"楊河 宏章"},{"name":"西良 浩一"},{"name":"原田 雅史"}]},"description":{"en":"Dynamic C-11 MET PET scans have the potential to be good predictors of discriminating MSLs in patients with primary unknown MSLs in clinical practice.","ja":"Dynamic C-11 MET PET scans have the potential to be good predictors of discriminating MSLs in patients with primary unknown MSLs in clinical practice."},"publication_date":"2020-08-26","publication_name":{"en":"European Journal of Hybrid Imaging","ja":"European Journal of Hybrid Imaging"},"volume":"Vol.26","number":"No.4","starting_page":"15","ending_page":"15","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1186/s41824-020-00083-x"],"issn":["2510-3636"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://ci.nii.ac.jp/naid/120006892839/","label":"url"},{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/115366","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1051975278323002880/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=373097","label":"url"}],"paper_title":{"en":"A case of juvenile fibroadenoma arising from axillary accessory mammary gland","ja":"腋窩副乳発生と考えられる若年性線維腺腫の1例"},"authors":{"en":[{"name":"Sasa Soichiroh"},{"name":"Inoue Hiroaki"},{"name":"Okumura Kazumasa"},{"name":"Aoyama Mariko"},{"name":"INUI Tomohiro"},{"name":"Toba Hiroaki"},{"name":"Yoshida Takahiro"},{"name":"Bando Yoshimi"},{"name":"Tangoku Akira"}],"ja":[{"name":"笹 聡一郎"},{"name":"井上 寛章"},{"name":"奥村 和正"},{"name":"青山 万理子"},{"name":"乾 友浩"},{"name":"鳥羽 博明"},{"name":"吉田 卓弘"},{"name":"坂東 良美"},{"name":"丹黒 章"}]},"description":{"en":"A case is20years old woman. She had previously noticed a mass in the left axilla. The mass grew, so she went to the hospital. Ultrasonography revealed a 71 × 51 mm well-defined tumor in the left axilla. We suspected a benign tumor but could not rule out axillary lymph node metastasis or accessory breast cancer. The findings of fine needle aspiration cytology suggested fibroadenoma or phyllodes tumor. Although we diagnosed fibroadenoma by needle biopsy, a definitive diagnosis was made by tumor resection because it is located in the axilla and large in size, and other diseases such as phyllodes tumors can be distinguished. The histopathological diagnosis of the excised specimen was juvenile fibroadenoma. We report a case of juvenile fibroadenoma arising from the axillary accessory mammary gland.","ja":"A case is20years old woman. She had previously noticed a mass in the left axilla. The mass grew, so she went to the hospital. Ultrasonography revealed a 71 × 51 mm well-defined tumor in the left axilla. We suspected a benign tumor but could not rule out axillary lymph node metastasis or accessory breast cancer. The findings of fine needle aspiration cytology suggested fibroadenoma or phyllodes tumor. Although we diagnosed fibroadenoma by needle biopsy, a definitive diagnosis was made by tumor resection because it is located in the axilla and large in size, and other diseases such as phyllodes tumors can be distinguished. The histopathological diagnosis of the excised specimen was juvenile fibroadenoma. We report a case of juvenile fibroadenoma arising from the axillary accessory mammary gland."},"publication_date":"2020-08-25","publication_name":{"en":"Shikoku Acta Medica","ja":"四国医学雑誌"},"volume":"Vol.76","number":"No.3,4","starting_page":"185","ending_page":"190","languages":["jpn"],"referee":true,"identifiers":{"issn":["0037-3699"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/115328","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/32535957","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85087562532&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=366787","label":"url"}],"paper_title":{"en":"Cancer-associated Adipocytes Promote Pancreatic Cancer Progression Through SAA1 Expression","ja":"Cancer-associated Adipocytes Promote Pancreatic Cancer Progression Through SAA1 Expression"},"authors":{"en":[{"name":"Takehara Masanori"},{"name":"Sato Yasushi"},{"name":"Kimura Tetsuo"},{"name":"Noda Kazuyoshi"},{"name":"Miyamoto Hiroshi"},{"name":"Fujino Yasuteru"},{"name":"Miyoshi Jinsei"},{"name":"Nakamura Fumika"},{"name":"Wada Hironori"},{"name":"Bando Yoshimi"},{"name":"Ikemoto Tetsuya"},{"name":"Shimada Mitsuo"},{"name":"Muguruma Naoki"},{"name":"Takayama Tetsuji"}],"ja":[{"name":"武原 正典"},{"name":"佐藤 康史"},{"name":"木村 哲夫"},{"name":"野田 和克"},{"name":"宮本 弘志"},{"name":"藤野 泰輝"},{"name":"三好 人正"},{"name":"中村 文香"},{"name":"Wada Hironori"},{"name":"坂東 良美"},{"name":"池本 哲也"},{"name":"島田 光生"},{"name":"六車 直樹"},{"name":"高山 哲治"}]},"description":{"en":"Although pancreatic cancer often invades into peripancreatic adipose tissue, little is known about the cancer-adipocyte interaction. We first investigated the ability of adipocytes to de-differentiate to cancer-associated adipocytes (CAAs) by co-culturing with pancreatic cancer cells. We then examined the effects of CAA-conditioned media (CAA-CM) on the malignant characteristics of cancer cells, the mechanism underlying those effects, and their clinical relevance in pancreatic cancer. When 3T3-L1 adipocytes were co-cultured with pancreatic cancer cells (PANC-1) using Transwell system, adipocytes lost their lipid droplets and morphologically changed to fibroblast-like cells (CAA). Adipocyte-specific marker mRNA levels significantly decreased but those of fibroblast-specific markers appeared, characteristic findings of CAA, as revealed by real-time PCR. When PANC-1 cells were cultured with CAA-CM, significantly higher migration/invasion capability, chemoresistance, and epithelial-mesenchymal transition (EMT) properties were observed compared with control cells. To investigate the mechanism underlying these effects, we performed microarray analysis of PANC-1 cells cultured with CAA-CM, and found 78.5-fold higher expression of SAA1 compared with control cells. When SAA1 gene in PANC-1 cells was knocked down with SAA1 siRNA, migration/invasion capability, chemoresistance, and EMT properties were significantly attenuated compared with control cells. Immunohistochemical analysis on human pancreatic cancer tissues revealed positive SAA1 expression in 46/61 (75.4%). Overall survival in the SAA1-positive group was significantly shorter than in the SAA1-negative group (p=0.013). In conclusion, we demonstrated that pancreatic cancer cells induced de-differentiation in adipocytes toward CAA, and CAA promoted malignant characteristics of pancreatic cancer via SAA1 expression, suggesting that SAA1 is a novel therapeutic target in pancreatic cancer.","ja":"Although pancreatic cancer often invades into peripancreatic adipose tissue, little is known about the cancer-adipocyte interaction. We first investigated the ability of adipocytes to de-differentiate to cancer-associated adipocytes (CAAs) by co-culturing with pancreatic cancer cells. We then examined the effects of CAA-conditioned media (CAA-CM) on the malignant characteristics of cancer cells, the mechanism underlying those effects, and their clinical relevance in pancreatic cancer. When 3T3-L1 adipocytes were co-cultured with pancreatic cancer cells (PANC-1) using Transwell system, adipocytes lost their lipid droplets and morphologically changed to fibroblast-like cells (CAA). Adipocyte-specific marker mRNA levels significantly decreased but those of fibroblast-specific markers appeared, characteristic findings of CAA, as revealed by real-time PCR. When PANC-1 cells were cultured with CAA-CM, significantly higher migration/invasion capability, chemoresistance, and epithelial-mesenchymal transition (EMT) properties were observed compared with control cells. To investigate the mechanism underlying these effects, we performed microarray analysis of PANC-1 cells cultured with CAA-CM, and found 78.5-fold higher expression of SAA1 compared with control cells. When SAA1 gene in PANC-1 cells was knocked down with SAA1 siRNA, migration/invasion capability, chemoresistance, and EMT properties were significantly attenuated compared with control cells. Immunohistochemical analysis on human pancreatic cancer tissues revealed positive SAA1 expression in 46/61 (75.4%). Overall survival in the SAA1-positive group was significantly shorter than in the SAA1-negative group (p=0.013). In conclusion, we demonstrated that pancreatic cancer cells induced de-differentiation in adipocytes toward CAA, and CAA promoted malignant characteristics of pancreatic cancer via SAA1 expression, suggesting that SAA1 is a novel therapeutic target in pancreatic cancer."},"publication_date":"2020-07-14","publication_name":{"en":"Cancer Science","ja":"Cancer Science"},"volume":"Vol.111","number":"No.8","starting_page":"2883","ending_page":"2894","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1111/cas.14527"],"issn":["1349-7006"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/32514881","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85086121909&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=373113","label":"url"}],"paper_title":{"en":"A case of long-term unchanged calcifying fibrous tumor","ja":"A case of long-term unchanged calcifying fibrous tumor"},"authors":{"en":[{"name":"Miyamoto Naoki"},{"name":"Yoshida Mitsuteru"},{"name":"Tsuboi Mitsuhiro"},{"name":"Otsuka Kenji"},{"name":"Bando Yoshimi"},{"name":"Kakimoto Takumi"},{"name":"Kawakita Naoya"},{"name":"Takizawa Hiromitsu"},{"name":"Kondo Kazuya"},{"name":"Tangoku Akira"}],"ja":[{"name":"宮本 直輝"},{"name":"吉田 光輝"},{"name":"坪井 光弘"},{"name":"大塚 憲司"},{"name":"坂東 良美"},{"name":"柿本 拓海"},{"name":"河北 直也"},{"name":"滝沢 宏光"},{"name":"近藤 和也"},{"name":"丹黒 章"}]},"description":{"en":"A calcifying fibrous tumor (CFT) is a rare benign tumor that may occur in any part of the body. We report the case of an asymptomatic 21-year-old woman with thoracic tumors. Chest computed tomography showed multiple masses in the left costophrenic angle. As we were unable to diagnose the tumor with a CT-guided needle biopsy, we performed a thoracoscopic biopsy. We found smooth multilobulated masses on the pleura and multiple small nodules around the main tumors. Partial resection of the tumor was performed by VATS. Histological examination revealed that the tumor had hypocellular fibrosclerotic tissue and distributed psammomatous calcifications with inflammatory infiltrates. Immunohistochemistry demonstrated that the spindle cells were partially positive for CD34 and CD99, but negative for anaplastic lymphoma kinase-1, smooth muscle actin, BCL-2, STAT6, and S-100 protein. The tumor was diagnosed as CFT. The patient's postoperative recovery was uneventful, and no progression of the lesions was observed during follow-up.","ja":"A calcifying fibrous tumor (CFT) is a rare benign tumor that may occur in any part of the body. We report the case of an asymptomatic 21-year-old woman with thoracic tumors. Chest computed tomography showed multiple masses in the left costophrenic angle. As we were unable to diagnose the tumor with a CT-guided needle biopsy, we performed a thoracoscopic biopsy. We found smooth multilobulated masses on the pleura and multiple small nodules around the main tumors. Partial resection of the tumor was performed by VATS. Histological examination revealed that the tumor had hypocellular fibrosclerotic tissue and distributed psammomatous calcifications with inflammatory infiltrates. Immunohistochemistry demonstrated that the spindle cells were partially positive for CD34 and CD99, but negative for anaplastic lymphoma kinase-1, smooth muscle actin, BCL-2, STAT6, and S-100 protein. The tumor was diagnosed as CFT. The patient's postoperative recovery was uneventful, and no progression of the lesions was observed during follow-up."},"publication_date":"2020-06-08","publication_name":{"en":"General Thoracic and Cardiovascular Surgery","ja":"General Thoracic and Cardiovascular Surgery"},"volume":"Vol.68","number":"No.12","starting_page":"1587","ending_page":"1590","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s11748-020-01396-1"],"issn":["1863-6713"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/31677131","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85074813194&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=365843","label":"url"}],"paper_title":{"en":"JMJD2A sensitizes gastric cancer to chemotherapy by cooperating with CCDC8.","ja":"JMJD2A sensitizes gastric cancer to chemotherapy by cooperating with CCDC8."},"authors":{"en":[{"name":"Nakagawa Tadahiko"},{"name":"Sato Yasushi"},{"name":"Tanahashi Toshihito"},{"name":"Mitsui Yasuhiro"},{"name":"Kida Yoshifumi"},{"name":"Fujino Yasuteru"},{"name":"Hirata Misato"},{"name":"Kitamura Shinji"},{"name":"Miyamoto Hiroshi"},{"name":"Okamoto Koichi"},{"name":"Muguruma Naoki"},{"name":"Bando Yoshimi"},{"name":"Takayama Tetsuji"}],"ja":[{"name":"中川 忠彦"},{"name":"佐藤 康史"},{"name":"棚橋 俊仁"},{"name":"三井 康裕"},{"name":"喜田 慶史"},{"name":"藤野 泰輝"},{"name":"Hirata Misato"},{"name":"北村 晋志"},{"name":"宮本 弘志"},{"name":"岡本 耕一"},{"name":"六車 直樹"},{"name":"坂東 良美"},{"name":"高山 哲治"}]},"description":{"en":"Jumonji domain-containing protein 2A (JMJD2A) of the JMJD2 family of histone lysine demethylases has been implicated in tumorigenesis. However, its expression and role in gastric cancer (GC) drug resistance remain unknown. Here, we investigated the role of JMJD2A in GC chemotherapeutic susceptibility and its clinical relevance in GC. We selected 12 relevant genes from previously identified gene signatures that can predict GC susceptibility to docetaxel, cisplatin, and S-1 (DCS) therapy. Each gene was knocked down using siRNA in GC cell lines, and cell viability assays were performed. JMJD2A expression in GC cell lines and tissues was assessed using qRT-PCR and immunohistochemistry, respectively. A JMJD2A downstream target related to drug susceptibility was examined using whole-gene expression array and immunoprecipitation. Among the 12 candidate genes, down-regulation of JMJD2A showed the maximum effect on GC susceptibility to anti-cancer drugs and increased the IC values for 5-FU, cisplatin, and docetaxel 15.3-, 2.7-, and 4.0-fold, respectively. JMJD2A was universally expressed in 12 GC cell lines, and its overexpression in GC tissue was positively correlated with tumor regression in 34 DCS-treated patients. A whole-gene expression array of JMJD2A-knockdown GC cells demonstrated a significant decrease in the expression of pro-apoptotic coiled-coil domain containing 8 (CCDC8), a downstream target of JMJD2A. Direct interaction between CCDC8 and JMJD2A was verified using immunoprecipitation. CCDC8 inhibition restored drug resistance to docetaxel, cisplatin, and S-1. Our results indicate that JMJD2A is a novel epigenetic factor affecting GC chemotherapeutic susceptibility, and JMJD2A/CCDC8 is a potential GC therapeutic target.","ja":"Jumonji domain-containing protein 2A (JMJD2A) of the JMJD2 family of histone lysine demethylases has been implicated in tumorigenesis. However, its expression and role in gastric cancer (GC) drug resistance remain unknown. Here, we investigated the role of JMJD2A in GC chemotherapeutic susceptibility and its clinical relevance in GC. We selected 12 relevant genes from previously identified gene signatures that can predict GC susceptibility to docetaxel, cisplatin, and S-1 (DCS) therapy. Each gene was knocked down using siRNA in GC cell lines, and cell viability assays were performed. JMJD2A expression in GC cell lines and tissues was assessed using qRT-PCR and immunohistochemistry, respectively. A JMJD2A downstream target related to drug susceptibility was examined using whole-gene expression array and immunoprecipitation. Among the 12 candidate genes, down-regulation of JMJD2A showed the maximum effect on GC susceptibility to anti-cancer drugs and increased the IC values for 5-FU, cisplatin, and docetaxel 15.3-, 2.7-, and 4.0-fold, respectively. JMJD2A was universally expressed in 12 GC cell lines, and its overexpression in GC tissue was positively correlated with tumor regression in 34 DCS-treated patients. A whole-gene expression array of JMJD2A-knockdown GC cells demonstrated a significant decrease in the expression of pro-apoptotic coiled-coil domain containing 8 (CCDC8), a downstream target of JMJD2A. Direct interaction between CCDC8 and JMJD2A was verified using immunoprecipitation. CCDC8 inhibition restored drug resistance to docetaxel, cisplatin, and S-1. Our results indicate that JMJD2A is a novel epigenetic factor affecting GC chemotherapeutic susceptibility, and JMJD2A/CCDC8 is a potential GC therapeutic target."},"publication_date":"2020-05","publication_name":{"en":"Gastric Cancer","ja":"Gastric Cancer"},"volume":"Vol.23","number":"No.3","starting_page":"426","ending_page":"436","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s10120-019-01024-9"],"issn":["1436-3305"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/32130543","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85081040433&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=373105","label":"url"}],"paper_title":{"en":"Use of a prognostic risk score that aggregates the FDG-PET/CT SUVmax, tumor size, and histologic group for predicting the prognosis of pStage I lung adenocarcinoma","ja":"Use of a prognostic risk score that aggregates the FDG-PET/CT SUVmax, tumor size, and histologic group for predicting the prognosis of pStage I lung adenocarcinoma"},"authors":{"en":[{"name":"Kawakita Naoya"},{"name":"Toba Hiroaki"},{"name":"Kawakami Yukikiyo"},{"name":"Takizawa Hiromitsu"},{"name":"Bando Yoshimi"},{"name":"Otsuka Hideki"},{"name":"Matsumoto Daisuke"},{"name":"Takashima Mika"},{"name":"Tsuboi Mitsuhiro"},{"name":"Yoshida Mitsuteru"},{"name":"Kondo Kazuya"},{"name":"Tangoku Akira"}],"ja":[{"name":"河北 直也"},{"name":"鳥羽 博明"},{"name":"川上 行奎"},{"name":"滝沢 宏光"},{"name":"坂東 良美"},{"name":"大塚 秀樹"},{"name":"松本 大資"},{"name":"髙嶋 美佳"},{"name":"坪井 光弘"},{"name":"吉田 光輝"},{"name":"近藤 和也"},{"name":"丹黒 章"}]},"description":{"en":"pStage I includes clinicopathologically diverse groups. This study aimed to identify the prognostic factors for pStage I lung adenocarcinoma. We retrospectively reviewed 208 patients with pStage I adenocarcinomas who underwent curative resection in our institute between 2006 and 2013. The maximum standardized uptake value (SUVmax) on [F18]-fluoro-deoxy-D-glucose positron emission tomography-computed tomography (PET/CT) was evaluated. Adenocarcinomas were categorized into the following histologic groups: group 0 (minimally invasive adenocarcinoma and lepidic predominant adenocarcinoma), group 1 (papillary predominant adenocarcinoma), and group 2 (acinar predominant adenocarcinoma and all the remaining subtypes). We assessed the relationship between disease-free survival (DFS) and clinicopathological factors. Multivariate analysis of DFS demonstrated that SUVmax > 3.0 (p < 0.001), total tumor size > 20 mm (p = 0.016), and histologic groups (p < 0.05) were independent prognostic factors. The prognostic risk score (PRS) was calculated using the following equation: PRS = SUVmax (≤ 3.0: 0 point, > 3.0: 2 points) + total tumor size (≤ 20 mm: 0 point, > 20 mm: 1 point) + histologic group (group 0: 0 point, group 1: 1 point, group 2: 2 points). Patients were divided into the following three risk groups: low-risk (PRS 0-2 points, n = 136), intermediate-risk (PRS 3-4 points, n = 49), and high-risk groups (PRS 5 points, n = 13). The 5-year DFS rates were 93.2%, 50.6%, and 30.8% for the low-, intermediate-, and high-risk groups, respectively (p < 0.001). The PRS aggregating the FDG-PET/CT SUVmax, total tumor size, and histologic group predicts the prognosis of pStage I lung adenocarcinoma.","ja":"pStage I includes clinicopathologically diverse groups. This study aimed to identify the prognostic factors for pStage I lung adenocarcinoma. We retrospectively reviewed 208 patients with pStage I adenocarcinomas who underwent curative resection in our institute between 2006 and 2013. The maximum standardized uptake value (SUVmax) on [F18]-fluoro-deoxy-D-glucose positron emission tomography-computed tomography (PET/CT) was evaluated. Adenocarcinomas were categorized into the following histologic groups: group 0 (minimally invasive adenocarcinoma and lepidic predominant adenocarcinoma), group 1 (papillary predominant adenocarcinoma), and group 2 (acinar predominant adenocarcinoma and all the remaining subtypes). We assessed the relationship between disease-free survival (DFS) and clinicopathological factors. Multivariate analysis of DFS demonstrated that SUVmax > 3.0 (p < 0.001), total tumor size > 20 mm (p = 0.016), and histologic groups (p < 0.05) were independent prognostic factors. The prognostic risk score (PRS) was calculated using the following equation: PRS = SUVmax (≤ 3.0: 0 point, > 3.0: 2 points) + total tumor size (≤ 20 mm: 0 point, > 20 mm: 1 point) + histologic group (group 0: 0 point, group 1: 1 point, group 2: 2 points). Patients were divided into the following three risk groups: low-risk (PRS 0-2 points, n = 136), intermediate-risk (PRS 3-4 points, n = 49), and high-risk groups (PRS 5 points, n = 13). The 5-year DFS rates were 93.2%, 50.6%, and 30.8% for the low-, intermediate-, and high-risk groups, respectively (p < 0.001). The PRS aggregating the FDG-PET/CT SUVmax, total tumor size, and histologic group predicts the prognosis of pStage I lung adenocarcinoma."},"publication_date":"2020-03-04","publication_name":{"en":"International Journal of Clinical Oncology","ja":"International Journal of Clinical Oncology"},"volume":"Vol.25","number":"No.6","starting_page":"1079","ending_page":"1089","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s10147-020-01637-6"],"issn":["1437-7772"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/115331","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=373106","label":"url"}],"paper_title":{"en":"Noninvasive monitoring of paclitaxel and lenvatinib efficacy against anaplastic thyroid cancer in orthotopic SCID mouse models using smallanimal FDGPET/CT","ja":"Noninvasive monitoring of paclitaxel and lenvatinib efficacy against anaplastic thyroid cancer in orthotopic SCID mouse models using smallanimal FDGPET/CT"},"authors":{"en":[{"name":"Aoyama Mariko"},{"name":"Takizawa Hiromitsu"},{"name":"Otani Tamaki"},{"name":"Inoue Seiya"},{"name":"Kawakita Naoya"},{"name":"Tsuboi Mitsuhiro"},{"name":"Bando Yoshimi"},{"name":"Uehara Hisanori"},{"name":"Kondo Kazuya"},{"name":"Tangoku Akira"}],"ja":[{"name":"青山 万理子"},{"name":"滝沢 宏光"},{"name":"大谷 環樹"},{"name":"井上 聖也"},{"name":"河北 直也"},{"name":"坪井 光弘"},{"name":"坂東 良美"},{"name":"上原 久典"},{"name":"近藤 和也"},{"name":"丹黒 章"}]},"publication_date":"2020","publication_name":{"en":"Oncology Reports","ja":"Oncology Reports"},"volume":"Vol.44","starting_page":"1709","ending_page":"1716","languages":["eng"],"referee":true,"identifiers":{"doi":["10.3892/or.2020.7720"],"issn":["1021-335X"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/114405","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/30449791","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85062415769&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=348787","label":"url"}],"paper_title":{"en":"Systemic Sarcoidosis Presenting with Renal Involvement Caused by Various Sarcoidosis-associated Pathophysiological Conditions","ja":"Systemic Sarcoidosis Presenting with Renal Involvement Caused by Various Sarcoidosis-associated Pathophysiological Conditions"},"authors":{"en":[{"name":"Murakami Taichi"},{"name":"Tamaki Masanori"},{"name":"Kishi Seiji"},{"name":"Nagai Kojiro"},{"name":"Abe Hideharu"},{"name":"Bando Yoshimi"},{"name":"Toyoda Yuko"},{"name":"Ogino Hirokazu"},{"name":"Nishioka Yasuhiko"},{"name":"Ueda Sayo"},{"name":"Doi Toshio"},{"name":"Matsuura Motokazu"}],"ja":[{"name":"村上 太一"},{"name":"田蒔 昌憲"},{"name":"岸 誠司"},{"name":"長井 幸二郎"},{"name":"安部 秀斉"},{"name":"坂東 良美"},{"name":"豊田 優子"},{"name":"荻野 広和"},{"name":"西岡 安彦"},{"name":"上田 紗代"},{"name":"土井 俊夫"},{"name":"松浦 元一"}]},"description":{"en":"A 61-year-old man was diagnosed with sarcoidosis involving the lungs, eyes, parotid gland and extrathoracic lymph nodes complicated by chronic kidney injury and hypercalcemia. Kidney biopsy showed non-specific interstitial nephritis and nephrosclerosis. However, immunohistochemical staining of cell surface markers revealed a multinucleated giant macrophage surrounded by T-cells, suggesting granulomatous interstitial nephritis. Corticosteroid improved the kidney function, and reduced the serum levels of calcium and angiotensin-converting enzyme. Sarcoid nephropathy may be caused by the combination of several sarcoidosis-associated pathophysiological conditions and a comprehensive kidney examination should be performed to assess the type of injury when determining a treatment strategy.","ja":"A 61-year-old man was diagnosed with sarcoidosis involving the lungs, eyes, parotid gland and extrathoracic lymph nodes complicated by chronic kidney injury and hypercalcemia. Kidney biopsy showed non-specific interstitial nephritis and nephrosclerosis. However, immunohistochemical staining of cell surface markers revealed a multinucleated giant macrophage surrounded by T-cells, suggesting granulomatous interstitial nephritis. Corticosteroid improved the kidney function, and reduced the serum levels of calcium and angiotensin-converting enzyme. Sarcoid nephropathy may be caused by the combination of several sarcoidosis-associated pathophysiological conditions and a comprehensive kidney examination should be performed to assess the type of injury when determining a treatment strategy."},"publication_date":"2019-03-01","publication_name":{"en":"Internal Medicine","ja":"Internal Medicine"},"volume":"Vol.58","number":"No.5","starting_page":"679","ending_page":"684","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2169/internalmedicine.1558-18"],"issn":["1349-7235"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/30711948","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=355460","label":"url"}],"paper_title":{"en":"Low Expression of Toll-like Receptor 4 Is Associated With Poor Prognosis in Bladder Cancer.","ja":"Low Expression of Toll-like Receptor 4 Is Associated With Poor Prognosis in Bladder Cancer."},"authors":{"en":[{"name":"Kusuhara Yoshito"},{"name":"Daizumoto Kei"},{"name":"Kawai Kaichi"},{"name":"Hirayama Kento"},{"name":"Kowada Minoru"},{"name":"Shintani Terumichi"},{"name":"Fukuhara Yayoi"},{"name":"Dondoo Tsogt-Ochir"},{"name":"Ozaki Keisuke"},{"name":"Tsuda Megumi"},{"name":"Fukawa Tomoya"},{"name":"Nakatsuji Hiroyoshi"},{"name":"Bando Yoshimi"},{"name":"Uehara Hisanori"},{"name":"Fukumori Tomoharu"},{"name":"Takahashi Masayuki"},{"name":"Kanayama Hiro-omi"}],"ja":[{"name":"楠原 義人"},{"name":"大豆本 圭"},{"name":"Kawai Kaichi"},{"name":"Hirayama Kento"},{"name":"Kowada Minoru"},{"name":"新谷 晃理"},{"name":"福原 弥生"},{"name":"Dondoo Tsogt-Ochir"},{"name":"Ozaki Keisuke"},{"name":"Tsuda Megumi"},{"name":"布川 朋也"},{"name":"中逵 弘能"},{"name":"坂東 良美"},{"name":"上原 久典"},{"name":"福森 知治"},{"name":"高橋 正幸"},{"name":"金山 博臣"}]},"description":{"en":"Low TLR4 expression was correlated with tumor progression.","ja":"Low TLR4 expression was correlated with tumor progression."},"publication_date":"2019-02","publication_name":{"en":"Anticancer Research","ja":"Anticancer Research"},"volume":"Vol.39","number":"No.2","starting_page":"703","ending_page":"711","languages":["eng"],"referee":true,"identifiers":{"doi":["10.21873/anticanres.13166"],"issn":["1791-7530"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/30056613","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85050721343&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=341950","label":"url"}],"paper_title":{"en":"Massive hemobilia following plastic stent removal in common bile duct cancer associated with primary sclerosing cholangitis (with video).","ja":"Massive hemobilia following plastic stent removal in common bile duct cancer associated with primary sclerosing cholangitis (with video)."},"authors":{"en":[{"name":"Miyamoto Hiroshi"},{"name":"Tanaka Kumiko"},{"name":"Nakamura Fumika"},{"name":"Ikeda Takahiro"},{"name":"Kitamura Shinji"},{"name":"Kimura Tetsuo"},{"name":"Okamoto Koichi"},{"name":"Sogabe Masahiro"},{"name":"Muguruma Naoki"},{"name":"Bando Yoshimi"},{"name":"Takayama Tetsuji"}],"ja":[{"name":"宮本 弘志"},{"name":"田中 久美子"},{"name":"中村 文香"},{"name":"池田 敬洋"},{"name":"北村 晋志"},{"name":"木村 哲夫"},{"name":"岡本 耕一"},{"name":"曽我部 正弘"},{"name":"六車 直樹"},{"name":"坂東 良美"},{"name":"高山 哲治"}]},"description":{"en":"Hemobilia is defined as bleeding into the biliary tract. Herein, we report a very rare case of massive hemobilia following plastic stent (PS) removal in common bile duct (CBD) cancer. A 72-year-old man with primary sclerosing cholangitis had undergone repeated insertion of a PS into the CBD. Biliary tract biopsy was performed based on suspicion of combined CBD cancer. Biopsy revealed poorly differentiated adenocarcinoma of the CBD. One month after the biliary tract biopsy, he was admitted for acute cholangitis, and endoscopic retrograde cholangiography was performed for the exchange of the PS. When one of the two biliary PSs was removed, spurting bleeding from the major papilla began abruptly. The massive bleeding caused the patient to be in a pre-shock state. A retrieval balloon catheter was compressed against the papilla for hemostasis. Although he was treated conservatively, the patient developed a bloody discharge. Upper gastrointestinal endoscopy revealed that the pulsatile bleeding beside the PSs started immediately after the removal of the coagula. Emergent contrast-enhanced computed tomography showed right hepatic artery aneurysm across the CBD. Therefore, transarterial embolization was performed. The patient's post-therapeutic course was uneventful. He received chemotherapy, but died about a half year after hemobilia occurred.","ja":"Hemobilia is defined as bleeding into the biliary tract. Herein, we report a very rare case of massive hemobilia following plastic stent (PS) removal in common bile duct (CBD) cancer. A 72-year-old man with primary sclerosing cholangitis had undergone repeated insertion of a PS into the CBD. Biliary tract biopsy was performed based on suspicion of combined CBD cancer. Biopsy revealed poorly differentiated adenocarcinoma of the CBD. One month after the biliary tract biopsy, he was admitted for acute cholangitis, and endoscopic retrograde cholangiography was performed for the exchange of the PS. When one of the two biliary PSs was removed, spurting bleeding from the major papilla began abruptly. The massive bleeding caused the patient to be in a pre-shock state. A retrieval balloon catheter was compressed against the papilla for hemostasis. Although he was treated conservatively, the patient developed a bloody discharge. Upper gastrointestinal endoscopy revealed that the pulsatile bleeding beside the PSs started immediately after the removal of the coagula. Emergent contrast-enhanced computed tomography showed right hepatic artery aneurysm across the CBD. Therefore, transarterial embolization was performed. The patient's post-therapeutic course was uneventful. He received chemotherapy, but died about a half year after hemobilia occurred."},"publication_date":"2019-02","publication_name":{"en":"Clinical Journal of Gastroenterology","ja":"Clinical Journal of Gastroenterology"},"volume":"Vol.12","number":"No.1","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s12328-018-0888-7"],"issn":["1865-7265"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116223","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/30270253","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=346361","label":"url"}],"paper_title":{"en":"Evaluation of Red Degeneration of Uterine Leiomyoma with Susceptibility-weighted MR Imaging","ja":"Evaluation of Red Degeneration of Uterine Leiomyoma with Susceptibility-weighted MR Imaging"},"authors":{"en":[{"name":"Takeuchi Mayumi"},{"name":"Matsuzaki Kenji"},{"name":"Bando Yoshimi"},{"name":"Harada Masafumi"}],"ja":[{"name":"竹内 麻由美"},{"name":"松崎 健司"},{"name":"坂東 良美"},{"name":"原田 雅史"}]},"publication_date":"2018-10-01","publication_name":{"en":"Magnetic Resonance in Medical Sciences","ja":"Magnetic Resonance in Medical Sciences"},"volume":"Vol.18","number":"No.2","starting_page":"158","ending_page":"162","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2463/mrms.mp.2018-0074"],"issn":["1880-2206"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/115710","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/30112272","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=347644","label":"url"}],"paper_title":{"en":"A case of pulmonary pleomorphic carcinoma with malignant phenotypes induced by ZEB1-associated epithelial-mesenchymal transition.","ja":"A case of pulmonary pleomorphic carcinoma with malignant phenotypes induced by ZEB1-associated epithelial-mesenchymal transition."},"authors":{"en":[{"name":"Kondo Mayo"},{"name":"Ogino Hirokazu"},{"name":"Ogawa Hirohisa"},{"name":"Afroj Tania"},{"name":"Toyoda Yuko"},{"name":"Sakaguchi Satoshi"},{"name":"Tsuboi Miki"},{"name":"Bando Yoshimi"},{"name":"Goto Hisatsugu"},{"name":"Tsuneyama Koichi"},{"name":"Nishioka Yasuhiko"}],"ja":[{"name":"Kondo Mayo"},{"name":"荻野 広和"},{"name":"小川 博久"},{"name":"Afroj Tania"},{"name":"豊田 優子"},{"name":"坂口 暁"},{"name":"Tsuboi Miki"},{"name":"坂東 良美"},{"name":"後東 久嗣"},{"name":"常山 幸一"},{"name":"西岡 安彦"}]},"description":{"en":"A 60-year-old man was admitted to our hospital with non-small cell lung cancer (NSCLC). Imaging and pathological studies revealed NSCLC, not otherwise specified (NOS), at clinical stage T3N1M0 stage IIIA. We started radiotherapy alone because of obstructive pneumonia and end-stage renal disease, but the tumors progressed rapidly and resulted in death due to air obstruction by pharyngeal metastasis. The cancer was diagnosed as pleomorphic carcinoma in an autopsy. Viable lung tumor cells, which were resistant to radiotherapy, and the pharyngeal metastasis had mesenchymal phenotypes and expressed ZEB1 but not SNAI1. These observations indicated that ZEB1-associated epithelial-mesenchymal transition has malignant features including resistance to radiotherapy and aggressive metastatic potential. ZEB1-associated EMT may be an important mechanism to understand the pathophysiology of pleomorphic carcinoma.","ja":"A 60-year-old man was admitted to our hospital with non-small cell lung cancer (NSCLC). Imaging and pathological studies revealed NSCLC, not otherwise specified (NOS), at clinical stage T3N1M0 stage IIIA. We started radiotherapy alone because of obstructive pneumonia and end-stage renal disease, but the tumors progressed rapidly and resulted in death due to air obstruction by pharyngeal metastasis. The cancer was diagnosed as pleomorphic carcinoma in an autopsy. Viable lung tumor cells, which were resistant to radiotherapy, and the pharyngeal metastasis had mesenchymal phenotypes and expressed ZEB1 but not SNAI1. These observations indicated that ZEB1-associated epithelial-mesenchymal transition has malignant features including resistance to radiotherapy and aggressive metastatic potential. ZEB1-associated EMT may be an important mechanism to understand the pathophysiology of pleomorphic carcinoma."},"publication_date":"2018-08-03","publication_name":{"en":"Respiratory Medicine Case Reports","ja":"Respiratory Medicine Case Reports"},"volume":"Vol.25","starting_page":"119","ending_page":"121","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.rmcr.2018.07.008"],"issn":["2213-0071"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/29968043","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85049558259&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=340817","label":"url"}],"paper_title":{"en":"First report of an Asian family with gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) revealed with the germline mutation of the APC exon 1B promoter region.","ja":"First report of an Asian family with gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) revealed with the germline mutation of the APC exon 1B promoter region."},"authors":{"en":[{"name":"Mitsui Yasuhiro"},{"name":"Yokoyama Reiko"},{"name":"Fujimoto Shota"},{"name":"Kagemoto Kaizoh"},{"name":"Kitamura Shinji"},{"name":"Okamoto Koichi"},{"name":"Muguruma Naoki"},{"name":"Bando Yoshimi"},{"name":"Eguchi Hidetaka"},{"name":"Okazaki Yasushi"},{"name":"Ishida Hideyuki"},{"name":"Takayama Tetsuji"}],"ja":[{"name":"三井 康裕"},{"name":"Yokoyama Reiko"},{"name":"藤本 将太"},{"name":"影本 開三"},{"name":"北村 晋志"},{"name":"岡本 耕一"},{"name":"六車 直樹"},{"name":"坂東 良美"},{"name":"Eguchi Hidetaka"},{"name":"Okazaki Yasushi"},{"name":"Ishida Hideyuki"},{"name":"高山 哲治"}]},"description":{"en":"A 48-year-old Japanese female with left hypochondralgia presented at our hospital. Esophagogastroduodenoscopy (EGD) revealed gastric cancers and carpeting fundic gland polyposis (FGPs) without Helicobacter pylori infection. Computed tomography showed multiple liver metastases. Total colonoscopy revealed a colonic tubular adenoma but not polyposis. She was diagnosed as having advanced gastric cancer with liver metastasis and received chemotherapy. Her mother had died from gastric cancer, and her elderly brother and niece had FGPs as revealed by EGD. Thus, the pedigree was diagnosed as gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS). Germline mutation analysis exhibited a point mutation in exon1B of the APC gene (c.-191T > C). Adenocarcinoma showed a gastric mucinous phenotype and was positive for a somatic mutation of p53, suggesting that p53 mutation may play a role in FGPs carcinogenesis. This is the first family with GAPPS in Asia in whom germline mutation of APC exon 1B has been detected.","ja":"A 48-year-old Japanese female with left hypochondralgia presented at our hospital. Esophagogastroduodenoscopy (EGD) revealed gastric cancers and carpeting fundic gland polyposis (FGPs) without Helicobacter pylori infection. Computed tomography showed multiple liver metastases. Total colonoscopy revealed a colonic tubular adenoma but not polyposis. She was diagnosed as having advanced gastric cancer with liver metastasis and received chemotherapy. Her mother had died from gastric cancer, and her elderly brother and niece had FGPs as revealed by EGD. Thus, the pedigree was diagnosed as gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS). Germline mutation analysis exhibited a point mutation in exon1B of the APC gene (c.-191T > C). Adenocarcinoma showed a gastric mucinous phenotype and was positive for a somatic mutation of p53, suggesting that p53 mutation may play a role in FGPs carcinogenesis. This is the first family with GAPPS in Asia in whom germline mutation of APC exon 1B has been detected."},"publication_date":"2018-07-02","publication_name":{"en":"Gastric Cancer","ja":"Gastric Cancer"},"volume":"Vol.21","number":"No.6","starting_page":"1058","ending_page":"1063","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s10120-018-0855-5"],"issn":["1436-3305"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/115584","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/29794407","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=340354","label":"url"}],"paper_title":{"en":"A Case of Uterine Tumor Resembling Ovarian Sex-cord Tumor (UTROSCT) Exhibiting Similar Imaging Characteristics to Those of Ovarian Sex-cord Tumor.","ja":"A Case of Uterine Tumor Resembling Ovarian Sex-cord Tumor (UTROSCT) Exhibiting Similar Imaging Characteristics to Those of Ovarian Sex-cord Tumor."},"authors":{"en":[{"name":"Takeuchi Mayumi"},{"name":"Matsuzaki Kenji"},{"name":"Bando Yoshimi"},{"name":"Nishimura Masato"},{"name":"Hayashi Aki"},{"name":"Harada Masafumi"}],"ja":[{"name":"竹内 麻由美"},{"name":"松崎 健司"},{"name":"坂東 良美"},{"name":"西村 正人"},{"name":"林 亜紀"},{"name":"原田 雅史"}]},"publication_date":"2018-05-24","publication_name":{"en":"Magnetic Resonance in Medical Sciences","ja":"Magnetic Resonance in Medical Sciences"},"volume":"Vol.18","number":"No.2","starting_page":"113","ending_page":"114","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2463/mrms.ci.2017-0177"],"issn":["1880-2206"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/29491110","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=353847","label":"url"}],"paper_title":{"en":"Ki-67 and Survivin as Predictive Factors for Rectal Cancer Treated with Preoperative Chemoradiotherapy.","ja":"Ki-67 and Survivin as Predictive Factors for Rectal Cancer Treated with Preoperative Chemoradiotherapy."},"authors":{"en":[{"name":"Yoshikawa Kouzou"},{"name":"Shimada Mitsuo"},{"name":"Higashijima Jun"},{"name":"Nakao Toshihiro"},{"name":"Nishi Masaaki"},{"name":"Takasu Chie"},{"name":"Kashihara Hideya"},{"name":"Eto Syohei"},{"name":"Bando Yoshimi"}],"ja":[{"name":"吉川 幸造"},{"name":"島田 光生"},{"name":"東島 潤"},{"name":"中尾 寿宏"},{"name":"西 正暁"},{"name":"髙須 千絵"},{"name":"柏原 秀也"},{"name":"江藤 祥平"},{"name":"坂東 良美"}]},"description":{"en":"To evaluate the usefulness of Ki-67 index and survivin as predictive prognostic factors for rectal cancer treated with preoperative chemoradiotherapy. The Ki-67 index and survivin expression were examined in patients with stage II/III rectal cancer (n=46) by immunohistochemistry. Patients were divided into a high-group and a low-group for the Ki-67 index, and positive and negative groups for survivin expression. Overall and disease-free survival were compared between the groups, and the correlation between Ki-67 index and survivin expression was assessed. The 5-year disease-free survival rate of the group with high Ki-67 index was significantly lower than that of the group with low Ki-67 index (53% and 88%, p=0.03), as was the 5-year overall survival rate (68% and 100%, p=0.03). Findings for survivin were not significant. Ki-67 index and survivin may be useful biomarkers for rectal cancer with preoperative CRT.","ja":"To evaluate the usefulness of Ki-67 index and survivin as predictive prognostic factors for rectal cancer treated with preoperative chemoradiotherapy. The Ki-67 index and survivin expression were examined in patients with stage II/III rectal cancer (n=46) by immunohistochemistry. Patients were divided into a high-group and a low-group for the Ki-67 index, and positive and negative groups for survivin expression. Overall and disease-free survival were compared between the groups, and the correlation between Ki-67 index and survivin expression was assessed. The 5-year disease-free survival rate of the group with high Ki-67 index was significantly lower than that of the group with low Ki-67 index (53% and 88%, p=0.03), as was the 5-year overall survival rate (68% and 100%, p=0.03). Findings for survivin were not significant. Ki-67 index and survivin may be useful biomarkers for rectal cancer with preoperative CRT."},"publication_date":"2018-03","publication_name":{"en":"Anticancer Research","ja":"Anticancer Research"},"volume":"Vol.38","number":"No.3","starting_page":"1735","ending_page":"1739","languages":["eng"],"referee":true,"identifiers":{"doi":["10.21873/anticanres.12409"],"issn":["1791-7530"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/29277815","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85039796842&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=351462","label":"url"}],"paper_title":{"en":"The Outcome of Sorafenib Therapy on Unresectable Hepatocellular Carcinoma: Experience of Conversion and Salvage Hepatectomy.","ja":"The Outcome of Sorafenib Therapy on Unresectable Hepatocellular Carcinoma: Experience of Conversion and Salvage Hepatectomy."},"authors":{"en":[{"name":"Yoshimoto Toshiaki"},{"name":"Imura Satoru"},{"name":"Morine Yuji"},{"name":"Ikemoto Tetsuya"},{"name":"Arakawa Yusuke"},{"name":"Iwahashi Shuichi"},{"name":"Saitou Yu"},{"name":"Takasu Chie"},{"name":"Ishikawa Daichi"},{"name":"Teraoku Hiroki"},{"name":"Bando Yoshimi"},{"name":"Shimada Mitsuo"}],"ja":[{"name":"良元 俊昭"},{"name":"居村 暁"},{"name":"森根 裕二"},{"name":"池本 哲也"},{"name":"荒川 悠佑"},{"name":"岩橋 衆一"},{"name":"齋藤 裕"},{"name":"髙須 千絵"},{"name":"石川 大地"},{"name":"寺奥 大貴"},{"name":"坂東 良美"},{"name":"島田 光生"}]},"description":{"en":"We report the outcomes of sorafenib therapy for advanced hepatocellular carcinoma (HCC) in our Department. Thirty-eight patients with unresectable HCC who were administrated sorafenib from 2009 to 2015 were investigated retrospectively. The 1-year overall survival rate was 59.3%. The macroscopic vascular invasion and response rate were independent prognostic factors of survival. Surgical resection after sorafenib achieved long-term survival in two cases. Case 1: A patient with locally unresectable HCC showed significant response induced by sorafenib, which allowed complete surgical resection. This tumor tested positive for FGF4. Case 2: A patient with a history of hepatectomy for HCC had multiple distant metastases. Most lesions were reduced in size after sorafenib therapy and new lesions in the remnant liver and residual lung metastases were resected. The sorafenib-resistant lesions were negative for FGF4. Sorafenib combined with surgical resection is a feasible option in advanced HCC patients, if sorafenib has been effective.","ja":"We report the outcomes of sorafenib therapy for advanced hepatocellular carcinoma (HCC) in our Department. Thirty-eight patients with unresectable HCC who were administrated sorafenib from 2009 to 2015 were investigated retrospectively. The 1-year overall survival rate was 59.3%. The macroscopic vascular invasion and response rate were independent prognostic factors of survival. Surgical resection after sorafenib achieved long-term survival in two cases. Case 1: A patient with locally unresectable HCC showed significant response induced by sorafenib, which allowed complete surgical resection. This tumor tested positive for FGF4. Case 2: A patient with a history of hepatectomy for HCC had multiple distant metastases. Most lesions were reduced in size after sorafenib therapy and new lesions in the remnant liver and residual lung metastases were resected. The sorafenib-resistant lesions were negative for FGF4. Sorafenib combined with surgical resection is a feasible option in advanced HCC patients, if sorafenib has been effective."},"publication_date":"2018-01","publication_name":{"en":"Anticancer Research","ja":"Anticancer Research"},"volume":"Vol.38","number":"No.1","starting_page":"501","ending_page":"507","languages":["eng"],"referee":true,"identifiers":{"doi":["10.21873/anticanres.12250"],"issn":["1791-7530"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=340746","label":"url"}],"paper_title":{"en":"関節症性乾癬に続発した反応性アミロイドーシス","ja":"関節症性乾癬に続発した反応性アミロイドーシス"},"authors":{"en":[{"name":"Hirose Kenji"},{"name":"宮本 千暁"},{"name":"Matsudate Yoshihiro"},{"name":"Kubo Yoshiaki"},{"name":"Taniguchi Tatsuya"},{"name":"Bando Yoshimi"}],"ja":[{"name":"廣瀬 憲志"},{"name":"宮本 千暁"},{"name":"松立 吉弘"},{"name":"久保 宜明"},{"name":"谷口 達哉"},{"name":"坂東 良美"}]},"publication_date":"2017-12","publication_name":{"en":"Practical Dermatology","ja":"皮膚病診療"},"volume":"Vol.39","number":"No.12","starting_page":"1291","ending_page":"1294","languages":["jpn"],"referee":true,"identifiers":{"doi":["10.24733/J01268.2018134054"],"issn":["0387-7531"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/111442","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/29527554","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=335366","label":"url"}],"paper_title":{"en":"Linked color imaging enhances endoscopic detection of sessile serrated adenoma/polyps.","ja":"Linked color imaging enhances endoscopic detection of sessile serrated adenoma/polyps."},"authors":{"en":[{"name":"Fujimoto Daisaku"},{"name":"Muguruma Naoki"},{"name":"Okamoto Koichi"},{"name":"Fujino Yasuteru"},{"name":"Kagemoto Kaizoh"},{"name":"Okada Yasuyuki"},{"name":"Takaoka Yoshifumi"},{"name":"Mitsui Yasuhiro"},{"name":"Kitamura Shinji"},{"name":"Kimura Tetsuo"},{"name":"Miyamoto Hiroshi"},{"name":"Bando Yoshimi"},{"name":"Sonoda Tomoko"},{"name":"Takayama Tetsuji"}],"ja":[{"name":"藤本 大策"},{"name":"六車 直樹"},{"name":"岡本 耕一"},{"name":"藤野 泰輝"},{"name":"影本 開三"},{"name":"岡田 泰行"},{"name":"Takaoka Yoshifumi"},{"name":"三井 康裕"},{"name":"北村 晋志"},{"name":"木村 哲夫"},{"name":"宮本 弘志"},{"name":"坂東 良美"},{"name":"Sonoda Tomoko"},{"name":"高山 哲治"}]},"description":{"en":"Although new image-enhanced endoscopy (IEE) technologies such as blue laser imaging (BLI), BLI-bright, and linked color imaging (LCI) have been developed, their utility for the detection of sessile serrated adenoma/polyps (SSA/Ps) is still unclear. This study aimed to evaluate the utility of BLI, BLI-bright, and LCI for SSA/P detection in still image examinations and in a prospective randomized controlled trial (RCT). A group of 6 expert and non-expert endoscopists read 200 endoscopic still images containing SSA/P lesions using white light image (WLI), BLI, BLI-bright, and LCI. Color differences were calculated using the color space method. A prospective RCT of tandem colonoscopy with WLI and LCI was performed. Patients with SSA/P and those with a history of SSA/P that had been endoscopically removed were enrolled and randomly allocated to WLI-LCI or LCI-WLI groups. Additional endoscopic detection rates for SSA/P were compared between the 2 groups. LCI showed the highest SSA/P detection rate among the 4 modes for both expert and non-expert endoscopists. The detection rate with LCI for the 6 expert endoscopists (mean 98.3 ± standard deviation 2.0 %) was significantly higher than that with WLI (86.7 ± 6.0 %, < 0.01). Likewise, the detection rate with LCI for the 6 non-expert endoscopists (92.3 ± 2.9 %) was significantly higher than that with WLI (72.7 ± 11.5 %, < 0.01). The color difference of SSA/P with LCI was the highest among the 4 modes, and was significantly higher than with WLI (median 15.9, (interquartile range 13.7 - 20.6) vs. 10.2, (7.6 - 14.2); < 0.0001). In the RCT, a total of 44 patients (WLI-LCI 22 vs. LCI-WLI 22) underwent colonoscopy. The additional detection rate for SSA/P in the second inspection in the WLI-LCI group (21.6 %, 8/37) was significantly higher than in the LCI-WLI group (3.2 %, 1/31; = 0.02). The small, flat, non-mucus and isochromatic SSA/Ps in the transverse colon were detected more frequently in the second inspection with LCI. LCI was the most sensitive mode for SSA/P detection among WLI, BLI, BLI-bright, and LCI in the still image examinations. Our RCT strongly suggests that LCI is superior to conventional WLI for SSA/P detection during colonoscopy. UMIN000017599.","ja":"Although new image-enhanced endoscopy (IEE) technologies such as blue laser imaging (BLI), BLI-bright, and linked color imaging (LCI) have been developed, their utility for the detection of sessile serrated adenoma/polyps (SSA/Ps) is still unclear. This study aimed to evaluate the utility of BLI, BLI-bright, and LCI for SSA/P detection in still image examinations and in a prospective randomized controlled trial (RCT). A group of 6 expert and non-expert endoscopists read 200 endoscopic still images containing SSA/P lesions using white light image (WLI), BLI, BLI-bright, and LCI. Color differences were calculated using the color space method. A prospective RCT of tandem colonoscopy with WLI and LCI was performed. Patients with SSA/P and those with a history of SSA/P that had been endoscopically removed were enrolled and randomly allocated to WLI-LCI or LCI-WLI groups. Additional endoscopic detection rates for SSA/P were compared between the 2 groups. LCI showed the highest SSA/P detection rate among the 4 modes for both expert and non-expert endoscopists. The detection rate with LCI for the 6 expert endoscopists (mean 98.3 ± standard deviation 2.0 %) was significantly higher than that with WLI (86.7 ± 6.0 %, < 0.01). Likewise, the detection rate with LCI for the 6 non-expert endoscopists (92.3 ± 2.9 %) was significantly higher than that with WLI (72.7 ± 11.5 %, < 0.01). The color difference of SSA/P with LCI was the highest among the 4 modes, and was significantly higher than with WLI (median 15.9, (interquartile range 13.7 - 20.6) vs. 10.2, (7.6 - 14.2); < 0.0001). In the RCT, a total of 44 patients (WLI-LCI 22 vs. LCI-WLI 22) underwent colonoscopy. The additional detection rate for SSA/P in the second inspection in the WLI-LCI group (21.6 %, 8/37) was significantly higher than in the LCI-WLI group (3.2 %, 1/31; = 0.02). The small, flat, non-mucus and isochromatic SSA/Ps in the transverse colon were detected more frequently in the second inspection with LCI. LCI was the most sensitive mode for SSA/P detection among WLI, BLI, BLI-bright, and LCI in the still image examinations. Our RCT strongly suggests that LCI is superior to conventional WLI for SSA/P detection during colonoscopy. UMIN000017599."},"publication_date":"2017-12","publication_name":{"en":"Endoscopy International Open","ja":"Endoscopy International Open"},"volume":"Vol.6","number":"No.3","starting_page":"E322","ending_page":"E334","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1055/s-0043-124469"],"issn":["2364-3722"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/28965110","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85030724288&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=334027","label":"url"}],"paper_title":{"en":"Clinicopathological Assessment of Gastric Xanthomas as Potential Predictive Markers of Gastric Cancer.","ja":"Clinicopathological Assessment of Gastric Xanthomas as Potential Predictive Markers of Gastric Cancer."},"authors":{"en":[{"name":"Kitamura Shinji"},{"name":"Muguruma Naoki"},{"name":"Okamoto Koichi"},{"name":"Tanahashi Toshihito"},{"name":"Fukuya Akira"},{"name":"Tanaka Kumiko"},{"name":"Fujimoto Daisaku"},{"name":"Kimura Tetsuo"},{"name":"Miyamoto Hiroshi"},{"name":"Bando Yoshimi"},{"name":"Takeuchi Hisashi"},{"name":"Shiba Masako"},{"name":"Takayama Tetsuji"}],"ja":[{"name":"北村 晋志"},{"name":"六車 直樹"},{"name":"岡本 耕一"},{"name":"棚橋 俊仁"},{"name":"福家 慧"},{"name":"田中 久美子"},{"name":"藤本 大策"},{"name":"木村 哲夫"},{"name":"宮本 弘志"},{"name":"坂東 良美"},{"name":"Takeuchi Hisashi"},{"name":"Shiba Masako"},{"name":"高山 哲治"}]},"description":{"en":"Gastric xanthomas are frequently observed in the stomach as small yellowish plaques or nodules. A close relationship among Helicobacter pylori infection, atrophic gastritis, and xanthomas has been reported. We assessed the clinicopathological features of gastric cancer with or without xanthomas. A total of 91 patients who were diagnosed as having early gastric cancer were enrolled. We evaluated the gastritis status using scores for gastritis and atrophy, positivity of H. pylori infection, the prevalence rate of xanthomas, and the clinicopathological features of gastric cancer. Gastric xanthomas were observed in 72.5% of early gastric cancer cases. Scores for gastritis and atrophy were significantly higher in the xanthoma-positive group than those in the xanthoma-negative group. A higher prevalence of differentiated-type adenocarcinoma was found in the xanthoma-positive group. Among the cases with multiple gastric xanthomas, the prevalence of males was significantly higher than that of females. A high prevalence rate of gastric xanthomas in gastric cancer cases was shown. Xanthomas were highly associated with age, the severities of gastritis and atrophy, and differentiated-type adenocarcinoma. Regardless of the eradication of H. pylori, xanthomas may be useful predictive markers for the development of differentiated-type adenocarcinoma.","ja":"Gastric xanthomas are frequently observed in the stomach as small yellowish plaques or nodules. A close relationship among Helicobacter pylori infection, atrophic gastritis, and xanthomas has been reported. We assessed the clinicopathological features of gastric cancer with or without xanthomas. A total of 91 patients who were diagnosed as having early gastric cancer were enrolled. We evaluated the gastritis status using scores for gastritis and atrophy, positivity of H. pylori infection, the prevalence rate of xanthomas, and the clinicopathological features of gastric cancer. Gastric xanthomas were observed in 72.5% of early gastric cancer cases. Scores for gastritis and atrophy were significantly higher in the xanthoma-positive group than those in the xanthoma-negative group. A higher prevalence of differentiated-type adenocarcinoma was found in the xanthoma-positive group. Among the cases with multiple gastric xanthomas, the prevalence of males was significantly higher than that of females. A high prevalence rate of gastric xanthomas in gastric cancer cases was shown. Xanthomas were highly associated with age, the severities of gastritis and atrophy, and differentiated-type adenocarcinoma. Regardless of the eradication of H. pylori, xanthomas may be useful predictive markers for the development of differentiated-type adenocarcinoma."},"publication_date":"2017-09-30","publication_name":{"en":"Digestion","ja":"Digestion"},"volume":"Vol.96","number":"No.4","starting_page":"199","ending_page":"206","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1159/000481346"],"issn":["1421-9867"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/115063","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/28241409","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85030241581&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=323281","label":"url"}],"paper_title":{"en":"Twin Rectal Tonsils Mimicking Carcinoid or Mucosa-Associated Lymphoid Tissue Lymphoma.","ja":"Twin Rectal Tonsils Mimicking Carcinoid or Mucosa-Associated Lymphoid Tissue Lymphoma."},"authors":{"en":[{"name":"Takehara Masanori"},{"name":"Muguruma Naoki"},{"name":"Kitamura Shinji"},{"name":"Kimura Tetsuo"},{"name":"Okamoto Koichi"},{"name":"Miyamoto Hiroshi"},{"name":"Bando Yoshimi"},{"name":"Takayama Tetsuji"}],"ja":[{"name":"武原 正典"},{"name":"六車 直樹"},{"name":"北村 晋志"},{"name":"木村 哲夫"},{"name":"岡本 耕一"},{"name":"宮本 弘志"},{"name":"坂東 良美"},{"name":"高山 哲治"}]},"description":{"en":"The rectal tonsil is a rare polypoid lesion exclusively found in the rectum and is considered a reactive proliferation of the lymphoid tissue. Although this lesion is benign, we recommend that it should be differentiated from carcinoid or polypoid type of mucosaassociated lymphoid tissue (MALT) lymphomas, based on gross findings. In this case report, we describe a case of rectal lesions with a unique appearance in a 41-year-old man. Colonoscopy revealed two 5-mm-sized nodules located opposite from each other on the left and right sides of the lower rectum. Endoscopic mucosal resection was conducted. Histopathologically, both lesions were mainly located in the submucosa and consisted of prominent lymphoid follicles with germinal centers of various sizes. No immunoreactivity of Bcl-2 was seen in the germinal centers. Immunohistochemical staining for kappa and lambda light chains revealed a polyclonal pattern. Therefore, these lesions were diagnosed as rectal tonsils.","ja":"The rectal tonsil is a rare polypoid lesion exclusively found in the rectum and is considered a reactive proliferation of the lymphoid tissue. Although this lesion is benign, we recommend that it should be differentiated from carcinoid or polypoid type of mucosaassociated lymphoid tissue (MALT) lymphomas, based on gross findings. In this case report, we describe a case of rectal lesions with a unique appearance in a 41-year-old man. Colonoscopy revealed two 5-mm-sized nodules located opposite from each other on the left and right sides of the lower rectum. Endoscopic mucosal resection was conducted. Histopathologically, both lesions were mainly located in the submucosa and consisted of prominent lymphoid follicles with germinal centers of various sizes. No immunoreactivity of Bcl-2 was seen in the germinal centers. Immunohistochemical staining for kappa and lambda light chains revealed a polyclonal pattern. Therefore, these lesions were diagnosed as rectal tonsils."},"publication_date":"2017-09","publication_name":{"en":"Clinical Endoscopy","ja":"Clinical Endoscopy"},"volume":"Vol.50","number":"No.5","starting_page":"500","ending_page":"503","languages":["eng"],"referee":true,"identifiers":{"doi":["10.5946/ce.2016.157"],"issn":["2234-2400"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/114393","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/28566596","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85020067897&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=323309","label":"url"}],"paper_title":{"en":"Paraneoplastic hypocalcemia developed in gastric cancer accompanied by osteoblastic metastasis","ja":"Paraneoplastic hypocalcemia developed in gastric cancer accompanied by osteoblastic metastasis"},"authors":{"en":[{"name":"Okazaki Jun"},{"name":"Muguruma Naoki"},{"name":"Kitamura Shinji"},{"name":"Kimura Tetsuo"},{"name":"Okamoto Koichi"},{"name":"Miyamoto Hiroshi"},{"name":"Kishi Kazuhiro"},{"name":"Bando Yoshimi"},{"name":"Kondo Takeshi"},{"name":"Endo Itsuro"},{"name":"Abe Masahiro"},{"name":"Takayama Tetsuji"}],"ja":[{"name":"Okazaki Jun"},{"name":"六車 直樹"},{"name":"北村 晋志"},{"name":"木村 哲夫"},{"name":"岡本 耕一"},{"name":"宮本 弘志"},{"name":"岸 和弘"},{"name":"坂東 良美"},{"name":"近藤 剛史"},{"name":"遠藤 逸朗"},{"name":"安倍 正博"},{"name":"高山 哲治"}]},"description":{"en":"Paraneoplastic syndromes are generally defined as clinical disorders associated with malignant diseases, and hypocalcemia associated with cancer is a rare condition. A woman in her 60s was referred to our hospital for the further examination of massive ascites due to carcinoma of unknown primary origin. She complained of numbness around her lips, and marked hypocalcemia of 5.0 mg/dL was noted. After two courses of chemotherapy, computed tomography showed a decrease in the ascites, and her serum calcium level increased. Although hypocalcemia is a very rare condition in patients with gastric cancer, serum calcium values should be evaluated when neurological symptoms are observed.","ja":"Paraneoplastic syndromes are generally defined as clinical disorders associated with malignant diseases, and hypocalcemia associated with cancer is a rare condition. A woman in her 60s was referred to our hospital for the further examination of massive ascites due to carcinoma of unknown primary origin. She complained of numbness around her lips, and marked hypocalcemia of 5.0 mg/dL was noted. After two courses of chemotherapy, computed tomography showed a decrease in the ascites, and her serum calcium level increased. Although hypocalcemia is a very rare condition in patients with gastric cancer, serum calcium values should be evaluated when neurological symptoms are observed."},"publication_date":"2017-06-01","publication_name":{"en":"Internal Medicine","ja":"Internal Medicine"},"volume":"Vol.56","number":"No.11","starting_page":"1345","ending_page":"1349","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2169/internalmedicine.56.8545"],"issn":["1349-7235"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/112449","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/28555617","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85019970677&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=325303","label":"url"}],"paper_title":{"en":"A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells.","ja":"A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells."},"authors":{"en":[{"name":"Yoshimaru Tetsuro"},{"name":"Ono Masaya"},{"name":"Bando Yoshimi"},{"name":"Chen Yi-An"},{"name":"Mizuguchi Kenji"},{"name":"Shima Hiroshi"},{"name":"Komatsu Masato"},{"name":"Imoto Issei"},{"name":"Izumi Keisuke"},{"name":"Honda Junko"},{"name":"Miyoshi Yasuo"},{"name":"Sasa Mitsunori"},{"name":"Katagiri Toyomasa"}],"ja":[{"name":"吉丸 哲郎"},{"name":"Ono Masaya"},{"name":"坂東 良美"},{"name":"Chen Yi-An"},{"name":"Mizuguchi Kenji"},{"name":"Shima Hiroshi"},{"name":"Komatsu Masato"},{"name":"井本 逸勢"},{"name":"Izumi Keisuke"},{"name":"Honda Junko"},{"name":"Miyoshi Yasuo"},{"name":"Sasa Mitsunori"},{"name":"片桐 豊雅"}]},"description":{"en":"Approximately 70% of breast cancer cells express oestrogen receptor alpha (ER). Previous studies have shown that the Brefeldin A-inhibited guanine nucleotide-exchange protein 3-prohibitin 2 (BIG3-PHB2) complex has a crucial role in these cells. However, it remains unclear how BIG3 regulates the suppressive activity of PHB2. Here we demonstrate that BIG3 functions as an A-kinase anchoring protein that binds protein kinase A (PKA) and the isoform of the catalytic subunit of protein phosphatase 1 (PP1C), thereby dephosphorylating and inactivating PHB2. E2-induced PKA-mediated phosphorylation of BIG3-S305 and -S1208 serves to enhance PP1C activity, resulting in E2/ER signalling activation via PHB2 inactivation due to PHB2-S39 dephosphorylation. Furthermore, an analysis of independent cohorts of ER-positive breast cancers patients reveal that both BIG3 overexpression and PHB2-S39 dephosphorylation are strongly associated with poor prognosis. This is the first demonstration of the mechanism of E2/ER signalling activation via the BIG3-PKA-PP1C tri-complex in breast cancer cells.","ja":"Approximately 70% of breast cancer cells express oestrogen receptor alpha (ER). Previous studies have shown that the Brefeldin A-inhibited guanine nucleotide-exchange protein 3-prohibitin 2 (BIG3-PHB2) complex has a crucial role in these cells. However, it remains unclear how BIG3 regulates the suppressive activity of PHB2. Here we demonstrate that BIG3 functions as an A-kinase anchoring protein that binds protein kinase A (PKA) and the isoform of the catalytic subunit of protein phosphatase 1 (PP1C), thereby dephosphorylating and inactivating PHB2. E2-induced PKA-mediated phosphorylation of BIG3-S305 and -S1208 serves to enhance PP1C activity, resulting in E2/ER signalling activation via PHB2 inactivation due to PHB2-S39 dephosphorylation. Furthermore, an analysis of independent cohorts of ER-positive breast cancers patients reveal that both BIG3 overexpression and PHB2-S39 dephosphorylation are strongly associated with poor prognosis. This is the first demonstration of the mechanism of E2/ER signalling activation via the BIG3-PKA-PP1C tri-complex in breast cancer cells."},"publication_date":"2017-05-30","publication_name":{"en":"Nature Communications","ja":"Nature Communications"},"volume":"Vol.8","number":"No.15427","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1038/ncomms15427"],"issn":["2041-1723"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/28054178","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85008158342&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=322015","label":"url"}],"paper_title":{"en":"Hemosuccus pancreaticus caused by a mucinous cystic neoplasm of the pancreas.","ja":"Hemosuccus pancreaticus caused by a mucinous cystic neoplasm of the pancreas."},"authors":{"en":[{"name":"Matsumoto Yuri"},{"name":"Miyamoto Hiroshi"},{"name":"Fukuya Akira"},{"name":"Nakamura Fumika"},{"name":"Goji Takahiro"},{"name":"Kitamura Shinji"},{"name":"Kimura Tetsuo"},{"name":"Okamoto Koichi"},{"name":"Sogabe Masahiro"},{"name":"Muguruma Naoki"},{"name":"Shimada Mitsuo"},{"name":"Bando Yoshimi"},{"name":"Takayama Tetsuji"}],"ja":[{"name":"Matsumoto Yuri"},{"name":"宮本 弘志"},{"name":"Fukuya Akira"},{"name":"中村 文香"},{"name":"郷司 敬洋"},{"name":"北村 晋志"},{"name":"木村 哲夫"},{"name":"岡本 耕一"},{"name":"曽我部 正弘"},{"name":"六車 直樹"},{"name":"島田 光生"},{"name":"坂東 良美"},{"name":"高山 哲治"}]},"description":{"en":"Hemosuccus pancreaticus is a gastrointestinal hemorrhage through the main pancreatic duct. Here, we report a rare case of hemosuccus pancreaticus due to a mucinous cystic neoplasm of the pancreas. A 62-year-old woman who had been followed for a branch duct intraductal papillary mucinous neoplasm visited our emergency room due to severe abdominal pain and bloody discharge. Computed tomography revealed that the pancreatic cyst increased the tension of the wall and a high-density area indicative of bleeding into the cyst was observed. Endoscopy showed opening of and hemorrhaging from the papilla of Vater. The patient was diagnosed with hemosuccus pancreaticus caused by hemorrhaging into the cyst from the branch duct intraductal papillary mucinous neoplasm. Based on this diagnosis, elective distal pancreatectomy was performed. The histopathological diagnosis was a mucinous cystic neoplasm with intermediate-grade dysplasia based upon the pathological findings that fibrous ovarian-type stroma existed abundantly and the stroma cells were positive for progesterone receptor and inhibin. Hemosuccus pancreaticus caused by a mucinous cystic neoplasm is extremely rare and there has been only one case reported to date. In conclusion, it should be recognized that pancreatic cystic neoplasms including mucinous cystic neoplasms may cause hemosuccus pancreaticus.","ja":"Hemosuccus pancreaticus is a gastrointestinal hemorrhage through the main pancreatic duct. Here, we report a rare case of hemosuccus pancreaticus due to a mucinous cystic neoplasm of the pancreas. A 62-year-old woman who had been followed for a branch duct intraductal papillary mucinous neoplasm visited our emergency room due to severe abdominal pain and bloody discharge. Computed tomography revealed that the pancreatic cyst increased the tension of the wall and a high-density area indicative of bleeding into the cyst was observed. Endoscopy showed opening of and hemorrhaging from the papilla of Vater. The patient was diagnosed with hemosuccus pancreaticus caused by hemorrhaging into the cyst from the branch duct intraductal papillary mucinous neoplasm. Based on this diagnosis, elective distal pancreatectomy was performed. The histopathological diagnosis was a mucinous cystic neoplasm with intermediate-grade dysplasia based upon the pathological findings that fibrous ovarian-type stroma existed abundantly and the stroma cells were positive for progesterone receptor and inhibin. Hemosuccus pancreaticus caused by a mucinous cystic neoplasm is extremely rare and there has been only one case reported to date. In conclusion, it should be recognized that pancreatic cystic neoplasms including mucinous cystic neoplasms may cause hemosuccus pancreaticus."},"publication_date":"2017-04-01","publication_name":{"en":"Clinical Journal of Gastroenterology","ja":"Clinical Journal of Gastroenterology"},"volume":"Vol.10","number":"No.2","starting_page":"185","ending_page":"190","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s12328-016-0711-2"],"issn":["1865-7265"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/109690","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/26577115","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-84947424480&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=335758","label":"url"}],"paper_title":{"en":"CXCR4 Expression is Associated with Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma","ja":"CXCR4 Expression is Associated with Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma"},"authors":{"en":[{"name":"Goto Masakazu"},{"name":"Yoshida Takahiro"},{"name":"Yamamoto Yota"},{"name":"Furukita Yoshihito"},{"name":"Inoue Seiya"},{"name":"Fujiwara Satoshi"},{"name":"Kawakita Naoya"},{"name":"Nishino Takeshi"},{"name":"Minato Takuya"},{"name":"Yuasa Yasuhiro"},{"name":"Yamai Hiromichi"},{"name":"Takechi Hirokazu"},{"name":"Seike Jun-ichi"},{"name":"Bando Yoshimi"},{"name":"Tangoku Akira"}],"ja":[{"name":"後藤 正和"},{"name":"吉田 卓弘"},{"name":"山本 洋太"},{"name":"古北 由仁"},{"name":"井上 聖也"},{"name":"藤原 聡史"},{"name":"河北 直也"},{"name":"西野 豪志"},{"name":"湊 拓也"},{"name":"湯浅 康弘"},{"name":"山井 礼道"},{"name":"武知 浩和"},{"name":"清家 純一"},{"name":"坂東 良美"},{"name":"丹黒 章"}]},"description":{"en":"Chemokines and their receptors are known to play important roles in the tumorigenesis of many malignancies. The chemokine CXCL12 and its receptors CXCR4 and CXCR7 were suggested to be involved in cancer invasion and metastasis. The aim of this retrospective study was to evaluate the prognostic impact of the expressions of CXCL12, CXCR4 and CXCR7 in patients with esophageal squamous cell carcinoma (ESCC). We used immunohistochemistry (IHC) and reverse transcriptase-polymerase chain reaction (RT-PCR) to evaluate the expressions of CXCL12, CXCR4, and CXCR7 in ESCC patients' tumor biopsy specimens obtained during preoperative endoscopy or surgery. These results were compared with the patients' clinicopathological parameters and survival. IHC was conducted for 172 patients. High expression of CXCR4 in the cytoplasm and nuclei and that of CXCR7 were associated with poor cause-specific survival (CSS) (P= .002 and .010, respectively). The specimens from 52 of the 172 patients were examined by RT-PCR and quantitative real-time PCR. The expression levels of messenger RNA (mRNA) of CXCR4 and CXCR7 were significantly increased in the tumors compared with normal esophageal mucosae (P < .0001). The expression level of mRNA of CXCR4 was associated with poor recurrence-free survival and CSS (P = .012 and .038, respectively). CXCR4 expression is associated with poor prognosis in patients with ESCC.","ja":"Chemokines and their receptors are known to play important roles in the tumorigenesis of many malignancies. The chemokine CXCL12 and its receptors CXCR4 and CXCR7 were suggested to be involved in cancer invasion and metastasis. The aim of this retrospective study was to evaluate the prognostic impact of the expressions of CXCL12, CXCR4 and CXCR7 in patients with esophageal squamous cell carcinoma (ESCC). We used immunohistochemistry (IHC) and reverse transcriptase-polymerase chain reaction (RT-PCR) to evaluate the expressions of CXCL12, CXCR4, and CXCR7 in ESCC patients' tumor biopsy specimens obtained during preoperative endoscopy or surgery. These results were compared with the patients' clinicopathological parameters and survival. IHC was conducted for 172 patients. High expression of CXCR4 in the cytoplasm and nuclei and that of CXCR7 were associated with poor cause-specific survival (CSS) (P= .002 and .010, respectively). The specimens from 52 of the 172 patients were examined by RT-PCR and quantitative real-time PCR. The expression levels of messenger RNA (mRNA) of CXCR4 and CXCR7 were significantly increased in the tumors compared with normal esophageal mucosae (P < .0001). The expression level of mRNA of CXCR4 was associated with poor recurrence-free survival and CSS (P = .012 and .038, respectively). CXCR4 expression is associated with poor prognosis in patients with ESCC."},"publication_date":"2017-03","publication_name":{"en":"Annals of Surgical Oncology","ja":"Annals of Surgical Oncology"},"volume":"Vol.24","number":"No.3","starting_page":"832","ending_page":"840","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1245/s10434-015-4974-5"],"issn":["1534-4681"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/28303455","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85015616972&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=323307","label":"url"}],"paper_title":{"en":"Duodenal cancer in a young patient with Peuts-Jeghers syndrome harboring an entire deletion of the STK11 gene.","ja":"Duodenal cancer in a young patient with Peuts-Jeghers syndrome harboring an entire deletion of the STK11 gene."},"authors":{"en":[{"name":"Teramae Satoshi"},{"name":"Okamoto Koichi"},{"name":"Tanaka Kumiko"},{"name":"Matsumoto Reika"},{"name":"Kitamura Shinji"},{"name":"Kimura Tetsuo"},{"name":"Sogabe Masahiro"},{"name":"Miyamoto Hiroshi"},{"name":"Muguruma Naoki"},{"name":"Bando Yoshimi"},{"name":"Shimada Mitsuo"},{"name":"Takayama Tetsuji"}],"ja":[{"name":"Teramae Satoshi"},{"name":"岡本 耕一"},{"name":"田中 久美子"},{"name":"Matsumoto Reika"},{"name":"北村 晋志"},{"name":"木村 哲夫"},{"name":"曽我部 正弘"},{"name":"宮本 弘志"},{"name":"六車 直樹"},{"name":"坂東 良美"},{"name":"島田 光生"},{"name":"高山 哲治"}]},"publication_date":"2017-03","publication_name":{"en":"Clinical Journal of Gastroenterology","ja":"Clinical Journal of Gastroenterology"},"volume":"Vol.10","number":"No.3","starting_page":"232","ending_page":"239","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s12328-017-0731-6"],"issn":["1865-7257"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/111119","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/28954985","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=340994","label":"url"}],"paper_title":{"en":"A Novel Method of DAPI Staining for Differential Diagnosis of Renal Amyloidosis.","ja":"A Novel Method of DAPI Staining for Differential Diagnosis of Renal Amyloidosis."},"authors":{"en":[{"name":"Matsuura Motokazu"},{"name":"Abe Hideharu"},{"name":"Tominaga Tatsuya"},{"name":"Sakurai Akiko"},{"name":"Murakami Taichi"},{"name":"Kishi Seiji"},{"name":"Bando Yoshimi"},{"name":"Minakuchi Jun"},{"name":"Nagai Kojiro"},{"name":"Doi Toshio"}],"ja":[{"name":"松浦 元一"},{"name":"安部 秀斉"},{"name":"冨永 辰也"},{"name":"櫻井 明子"},{"name":"村上 太一"},{"name":"岸 誠司"},{"name":"坂東 良美"},{"name":"Minakuchi Jun"},{"name":"長井 幸二郎"},{"name":"土井 俊夫"}]},"description":{"en":"Amyloidosis is often overlooked because its clinical manifestations can mimic those of more-common diseases. It is important to get a precise diagnosis as early as possible for the prevention of further organ damages. Amyloidosis is a disorder caused by deposition of insoluble abnormal amyloid. The kidney is a frequent site of amyloid deposition. The amyloid fibrils have a characteristic appearance and generate birefringence under polarized light when stained with the Congo red dye. Classification of amyloidosis is based on the precursor protein that forms the amyloid fibrils and the distribution of amyloid deposits as either systemic or localized. Involvement of amyloid fibrils in kidneys mainly occurs as amyloid light-chain (AL) or amyloid A (AA) amyloidosis. The potassium permanganate method with Congo red staining was once used widely to discriminate AL and AA amyloidoses, but this method has a problem of false positive results. We found that extracellular and cytoplasmic glomerular 4', 6-diamidino-2-phenylindole (DAPI)-positive areas were clearly consistent with amyloid deposition in AL amyloidosis. In contrast, the overlapping staining was not seen in AA amyloidosis. Therefore, we propose that DAPI staining readily distinguishes AL renal amyloidosis from AA renal amyloidosis as a simple and reproducible histochemical method. J. Med. Invest. 64: 217-221, August, 2017.","ja":"Amyloidosis is often overlooked because its clinical manifestations can mimic those of more-common diseases. It is important to get a precise diagnosis as early as possible for the prevention of further organ damages. Amyloidosis is a disorder caused by deposition of insoluble abnormal amyloid. The kidney is a frequent site of amyloid deposition. The amyloid fibrils have a characteristic appearance and generate birefringence under polarized light when stained with the Congo red dye. Classification of amyloidosis is based on the precursor protein that forms the amyloid fibrils and the distribution of amyloid deposits as either systemic or localized. Involvement of amyloid fibrils in kidneys mainly occurs as amyloid light-chain (AL) or amyloid A (AA) amyloidosis. The potassium permanganate method with Congo red staining was once used widely to discriminate AL and AA amyloidoses, but this method has a problem of false positive results. We found that extracellular and cytoplasmic glomerular 4', 6-diamidino-2-phenylindole (DAPI)-positive areas were clearly consistent with amyloid deposition in AL amyloidosis. In contrast, the overlapping staining was not seen in AA amyloidosis. Therefore, we propose that DAPI staining readily distinguishes AL renal amyloidosis from AA renal amyloidosis as a simple and reproducible histochemical method. J. Med. Invest. 64: 217-221, August, 2017."},"publication_date":"2017","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.64","number":"No.3.4","starting_page":"217","ending_page":"221","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.64.217"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/114395","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/27803418","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=329382","label":"url"}],"paper_title":{"en":"An Autopsy Case of Aortic Intimal Sarcoma Initially Diagnosed as Polyarteritis Nodosa.","ja":"An Autopsy Case of Aortic Intimal Sarcoma Initially Diagnosed as Polyarteritis Nodosa."},"authors":{"en":[{"name":"Toyoda Yuko"},{"name":"Ozaki Ryohiko"},{"name":"Kishi Jun"},{"name":"Hanibuchi Masaki"},{"name":"Kinoshita Katsuhiro"},{"name":"Tezuka Toshifumi"},{"name":"Goto Hisatsugu"},{"name":"Ono Hiroyuki"},{"name":"Nagai Kojiro"},{"name":"Bando Yoshimi"},{"name":"Doi Toshio"},{"name":"Nishioka Yasuhiko"}],"ja":[{"name":"豊田 優子"},{"name":"Ozaki Ryohiko"},{"name":"岸 潤"},{"name":"埴淵 昌毅"},{"name":"木下 勝弘"},{"name":"手塚 敏史"},{"name":"後東 久嗣"},{"name":"Ono Hiroyuki"},{"name":"長井 幸二郎"},{"name":"坂東 良美"},{"name":"土井 俊夫"},{"name":"西岡 安彦"}]},"description":{"en":"A 61-year-old man had hypertension with stenosis in the left renal artery. When his fever, abdominal pain, and renal dysfunction progressed, he was admitted to our hospital. He was diagnosed with polyarthritis nodosa. His renal function rapidly deteriorated despite immunosuppressive therapy. His digestive tract perforated twice, and he subsequently died. An autopsy revealed that aortic intimal sarcoma caused stenosis in multiple arteries. Both polyarteritis nodosa and aortic intimal sarcoma are very rare diseases and the diagnoses are very difficult. It is very important to consider these entities when making a differential diagnosis of vasculitis.","ja":"A 61-year-old man had hypertension with stenosis in the left renal artery. When his fever, abdominal pain, and renal dysfunction progressed, he was admitted to our hospital. He was diagnosed with polyarthritis nodosa. His renal function rapidly deteriorated despite immunosuppressive therapy. His digestive tract perforated twice, and he subsequently died. An autopsy revealed that aortic intimal sarcoma caused stenosis in multiple arteries. Both polyarteritis nodosa and aortic intimal sarcoma are very rare diseases and the diagnoses are very difficult. It is very important to consider these entities when making a differential diagnosis of vasculitis."},"publication_date":"2016-11-01","publication_name":{"en":"Internal Medicine","ja":"Internal Medicine"},"volume":"Vol.55","number":"No.21","starting_page":"3191","ending_page":"3195","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2169/internalmedicine.55.7152"],"issn":["1349-7235"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/27669698","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-84991294478&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=322235","label":"url"}],"paper_title":{"en":"Congenital craniopharyngioma treated by radical surgery: case report and review of the literature","ja":"Congenital craniopharyngioma treated by radical surgery: case report and review of the literature"},"authors":{"en":[{"name":"Kageji Teruyoshi"},{"name":"Miyamoto Takeshi"},{"name":"Kotani Yumiko"},{"name":"Kaji Tuyoshi"},{"name":"Bando Yoshimi"},{"name":"Mizobuchi Yoshifumi"},{"name":"Nakajima Kohhei"},{"name":"Nagahiro Shinji"}],"ja":[{"name":"影治 照喜"},{"name":"宮本 健志"},{"name":"小谷 裕美子"},{"name":"Kaji Tuyoshi"},{"name":"坂東 良美"},{"name":"溝渕 佳史"},{"name":"中島 公平"},{"name":"永廣 信治"}]},"description":{"en":"Craniopharyngiomas are 5-10 % of all pediatric tumors, but are seldomly encountered in the perinatal period. Only seven instances of a truly antenatal diagnosis of a congenital craniopharyngioma that subsequently underwent radical surgery have been reported. We present the case of a patient who received the diagnosis of a suprasellar tumor during the prenatal period and received radical surgery. We report a case of a neonatal craniopharyngioma treated surgically. The pregnancy progressed uneventfully until a routine ultrasound at 37 weeks of gestation showed a 15 × 15 mm high echoic mass in the center of the fetal head. Neonatal Gd-enhanced T1-weighted MRI at 5 days of life showed a homogenously enhanced mass (16×22×15 mm) in the sellar and suprasellar lesion. As the tumor showed rapid growth at the 3rd month of life, the patient underwent a surgical treatment and the mass was totally removed. Three years later, the physical and mental development of the patient was normal, and Gd-MRI studies showed no tumor recurrence. The present case is the eighth case of a truly antenatal diagnosis of a craniopharyngioma that underwent successful radical surgery. Craniopharyngioma is a benign tumor and thought to be a slow growing tumor in childhood. The results of radical surgery were very poor, and the mortality and morbidity rates were high in the previous reports due to the huge size of tumor at operation. The present case demonstrated the rapid growth in short interval of Gd-MRI. This is the first report of tumor kinetics of congenital craniopharyngioma with previous reports. The calculated tumor doubling time in our case was 37 days.","ja":"Craniopharyngiomas are 5-10 % of all pediatric tumors, but are seldomly encountered in the perinatal period. Only seven instances of a truly antenatal diagnosis of a congenital craniopharyngioma that subsequently underwent radical surgery have been reported. We present the case of a patient who received the diagnosis of a suprasellar tumor during the prenatal period and received radical surgery. We report a case of a neonatal craniopharyngioma treated surgically. The pregnancy progressed uneventfully until a routine ultrasound at 37 weeks of gestation showed a 15 × 15 mm high echoic mass in the center of the fetal head. Neonatal Gd-enhanced T1-weighted MRI at 5 days of life showed a homogenously enhanced mass (16×22×15 mm) in the sellar and suprasellar lesion. As the tumor showed rapid growth at the 3rd month of life, the patient underwent a surgical treatment and the mass was totally removed. Three years later, the physical and mental development of the patient was normal, and Gd-MRI studies showed no tumor recurrence. The present case is the eighth case of a truly antenatal diagnosis of a craniopharyngioma that underwent successful radical surgery. Craniopharyngioma is a benign tumor and thought to be a slow growing tumor in childhood. The results of radical surgery were very poor, and the mortality and morbidity rates were high in the previous reports due to the huge size of tumor at operation. The present case demonstrated the rapid growth in short interval of Gd-MRI. This is the first report of tumor kinetics of congenital craniopharyngioma with previous reports. The calculated tumor doubling time in our case was 37 days."},"publication_date":"2016-09-26","publication_name":{"en":"Child's Nervous System","ja":"Child's Nervous System"},"volume":"Vol.33","number":"No.2","starting_page":"357","ending_page":"362","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s00381-016-3249-1"],"issn":["0256-7040"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/27262570","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=331242","label":"url"}],"paper_title":{"en":"Neuroendocrine carcinoma of the pancreas with similar genetic alterations to invasive ductal adenocarcinoma.","ja":"Neuroendocrine carcinoma of the pancreas with similar genetic alterations to invasive ductal adenocarcinoma."},"authors":{"en":[{"name":"Kimura Tetsuo"},{"name":"Miyamoto Hiroshi"},{"name":"Fukuya Akira"},{"name":"Kitamura Shinji"},{"name":"Okamoto Koichi"},{"name":"Kimura Masako"},{"name":"Muguruma Naoki"},{"name":"Ikemoto Tetsuya"},{"name":"Shimada Mitsuo"},{"name":"Yoneda Akiko"},{"name":"Bando Yoshimi"},{"name":"Takishita Makoto"},{"name":"Takayama Tetsuji"}],"ja":[{"name":"木村 哲夫"},{"name":"宮本 弘志"},{"name":"Fukuya Akira"},{"name":"北村 晋志"},{"name":"岡本 耕一"},{"name":"木村 雅子"},{"name":"六車 直樹"},{"name":"池本 哲也"},{"name":"島田 光生"},{"name":"米田 亜樹子"},{"name":"坂東 良美"},{"name":"Takishita Makoto"},{"name":"高山 哲治"}]},"description":{"en":"Neuroendocrine carcinoma (NEC) of the pancreas is very rare, and its origin is not fully elucidated. Here, we present a case of a small-size NEC of the pancreas that is genetically similar to invasive ductal adenocarcinoma (IDA). A 65-year-old man was referred to our hospital due to obstructive jaundice and found to have a 12-mm solid tumor in the pancreas head. The tumor exhibited low vascularity on enhanced computed tomography, and endoscopic retrograde pancreatographic imaging revealed an irregular obstruction in a branch duct of the pancreas. The patient was thereby diagnosed with a pancreatic ductal cancer, and stomach-preserving pancreaticoduodenectomy with regional lymph node resection was performed. Histochemical analysis of the resected tumor showed that the neoplastic cells with scanty cytoplasm and hyperchromatic nuclei strongly expressed chromogranin A and synaptophysin. The Ki-67 index was 40 % in the most proliferative tumor regions, and the tumor was diagnosed as a NEC of the pancreas. However, in the analysis of genetic alterations of the tumor tissue, the neoplastic cells showed altered KRAS, TP53, and SMAD4/DPC4, suggesting that the NEC in our case is genetically related to IDA. Our data suggest that poorly differentiated IDAs may transform into NECs.","ja":"Neuroendocrine carcinoma (NEC) of the pancreas is very rare, and its origin is not fully elucidated. Here, we present a case of a small-size NEC of the pancreas that is genetically similar to invasive ductal adenocarcinoma (IDA). A 65-year-old man was referred to our hospital due to obstructive jaundice and found to have a 12-mm solid tumor in the pancreas head. The tumor exhibited low vascularity on enhanced computed tomography, and endoscopic retrograde pancreatographic imaging revealed an irregular obstruction in a branch duct of the pancreas. The patient was thereby diagnosed with a pancreatic ductal cancer, and stomach-preserving pancreaticoduodenectomy with regional lymph node resection was performed. Histochemical analysis of the resected tumor showed that the neoplastic cells with scanty cytoplasm and hyperchromatic nuclei strongly expressed chromogranin A and synaptophysin. The Ki-67 index was 40 % in the most proliferative tumor regions, and the tumor was diagnosed as a NEC of the pancreas. However, in the analysis of genetic alterations of the tumor tissue, the neoplastic cells showed altered KRAS, TP53, and SMAD4/DPC4, suggesting that the NEC in our case is genetically related to IDA. Our data suggest that poorly differentiated IDAs may transform into NECs."},"publication_date":"2016-08","publication_name":{"en":"Clinical Journal of Gastroenterology","ja":"Clinical Journal of Gastroenterology"},"volume":"Vol.9","number":"No.4","starting_page":"261","ending_page":"265","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s12328-016-0655-6"],"issn":["1865-7265"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/27170298","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-84966709449&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=313072","label":"url"}],"paper_title":{"en":"Protein-losing enteropathy in a patient with familial adenomatous polyposis and advanced colon cancer.","ja":"Protein-losing enteropathy in a patient with familial adenomatous polyposis and advanced colon cancer."},"authors":{"en":[{"name":"Miyamoto Yoshihiko"},{"name":"Muguruma Naoki"},{"name":"Kimura Tetsuo"},{"name":"Okamoto Koichi"},{"name":"Sogabe Masahiro"},{"name":"Miyamoto Hiroshi"},{"name":"Kohno Seiya"},{"name":"Nakasono Masahiko"},{"name":"Hayashi Hiroshige"},{"name":"Bando Yoshimi"},{"name":"Takayama Tetsuji"}],"ja":[{"name":"Miyamoto Yoshihiko"},{"name":"六車 直樹"},{"name":"木村 哲夫"},{"name":"岡本 耕一"},{"name":"曽我部 正弘"},{"name":"宮本 弘志"},{"name":"Kohno Seiya"},{"name":"Nakasono Masahiko"},{"name":"Hayashi Hiroshige"},{"name":"坂東 良美"},{"name":"高山 哲治"}]},"description":{"en":"A 29-year-old female visited a hospital because of increasingly severe lower leg edema. She was diagnosed as having multiple polyps in the stomach and colon by gastroscopy and sigmoidoscopy as well as multiple liver tumors by abdominal CT. She was referred to our hospital for further examination. Total colonoscopy revealed a type 2 tumor in the transverse colon and more than 200 polyps distributed throughout the colorectum. Biopsies of the tumor and polyps showed histological characteristics of adenocarcinoma and tubulovillous adenoma, respectively. Thus, she was diagnosed as having metastatic colon cancer derived from familial adenomatous polyposis (FAP). Laboratory tests showed a marked hypoalbuminemia of 1.1 g/dl. The fecal alpha-1 anti-trypsin test showed abnormal clearance (62.1 ml/day), and scintigraphy using 99mTc-human serum albumin revealed protein loss in the whole colon. Multiple ligation probe amplification analysis of the APC gene identified a germline duplication of exons 11-13. Direct sequencing of the reverse transcription PCR products of APC mRNA revealed a deletion of 25 base pairs and a tandem duplication of exons 11-13. This case was considered to be protein-losing enteropathy resulting from numerous colonic tubulovillous adenomas and advanced colon cancer in a FAP patient with unusual mutational events in APC.","ja":"A 29-year-old female visited a hospital because of increasingly severe lower leg edema. She was diagnosed as having multiple polyps in the stomach and colon by gastroscopy and sigmoidoscopy as well as multiple liver tumors by abdominal CT. She was referred to our hospital for further examination. Total colonoscopy revealed a type 2 tumor in the transverse colon and more than 200 polyps distributed throughout the colorectum. Biopsies of the tumor and polyps showed histological characteristics of adenocarcinoma and tubulovillous adenoma, respectively. Thus, she was diagnosed as having metastatic colon cancer derived from familial adenomatous polyposis (FAP). Laboratory tests showed a marked hypoalbuminemia of 1.1 g/dl. The fecal alpha-1 anti-trypsin test showed abnormal clearance (62.1 ml/day), and scintigraphy using 99mTc-human serum albumin revealed protein loss in the whole colon. Multiple ligation probe amplification analysis of the APC gene identified a germline duplication of exons 11-13. Direct sequencing of the reverse transcription PCR products of APC mRNA revealed a deletion of 25 base pairs and a tandem duplication of exons 11-13. This case was considered to be protein-losing enteropathy resulting from numerous colonic tubulovillous adenomas and advanced colon cancer in a FAP patient with unusual mutational events in APC."},"publication_date":"2016-06","publication_name":{"en":"Clinical Journal of Gastroenterology","ja":"Clinical Journal of Gastroenterology"},"volume":"Vol.9","number":"No.3","starting_page":"134","ending_page":"139","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s12328-016-0650-y"],"issn":["1865-7257"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/26960725","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=309712","label":"url"}],"paper_title":{"en":"A case of polypoid endometriosis with malignant transformation.","ja":"A case of polypoid endometriosis with malignant transformation."},"authors":{"en":[{"name":"Takeuchi Mayumi"},{"name":"Matsuzaki Kenji"},{"name":"Bando Yoshimi"},{"name":"Nishimura Masato"},{"name":"Yoneda Akiko"},{"name":"Harada Masafumi"}],"ja":[{"name":"竹内 麻由美"},{"name":"松崎 健司"},{"name":"坂東 良美"},{"name":"西村 正人"},{"name":"米田 亜樹子"},{"name":"原田 雅史"}]},"description":{"en":"Polypoid endometriosis is a benign, rare variant of endometriosis which forms multiple polypoid nodules in the female pelvis mimicking malignant tumors; however, it may rarely cause malignant transformation. We report magnetic resonance imaging findings of a case of polypoid endometriosis with malignant transformation. Multiple high-signal intensity polypoid nodules in the cul-de-sac surrounded by low-signal intensity rim-like fibrous adhesion protruding to the posterior wall of the uterine body were demonstrated on T2-weighted images. The polypoid nodules showed weak contrast enhancement compared with that of uterine myometrium on post-contrast T1-weighted images, and slight high signal intensity on diffusion-weighted images with relatively high mean apparent diffusion coefficient. Reported cases of polypoid endometriosis showed intense contrast enhancement similar to that of uterine myometrium, and weak contrast enhancement similar to that of endometrial carcinoma may be suggestive for malignant transformation of polypoid endometriosis.","ja":"Polypoid endometriosis is a benign, rare variant of endometriosis which forms multiple polypoid nodules in the female pelvis mimicking malignant tumors; however, it may rarely cause malignant transformation. We report magnetic resonance imaging findings of a case of polypoid endometriosis with malignant transformation. Multiple high-signal intensity polypoid nodules in the cul-de-sac surrounded by low-signal intensity rim-like fibrous adhesion protruding to the posterior wall of the uterine body were demonstrated on T2-weighted images. The polypoid nodules showed weak contrast enhancement compared with that of uterine myometrium on post-contrast T1-weighted images, and slight high signal intensity on diffusion-weighted images with relatively high mean apparent diffusion coefficient. Reported cases of polypoid endometriosis showed intense contrast enhancement similar to that of uterine myometrium, and weak contrast enhancement similar to that of endometrial carcinoma may be suggestive for malignant transformation of polypoid endometriosis."},"publication_date":"2016-03-10","publication_name":{"en":"Abdominal Radiology","ja":"Abdominal Radiology"},"volume":"Vol.41","number":"No.9","starting_page":"1699","ending_page":"1702","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s00261-016-0696-9"],"issn":["2366-0058"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/114387","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/26875964","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=310783","label":"url"}],"paper_title":{"en":"Primary Pulmonary Synovial Sarcoma Showing a Prolonged Survival with Multimodality Therapy","ja":"Primary Pulmonary Synovial Sarcoma Showing a Prolonged Survival with Multimodality Therapy"},"authors":{"en":[{"name":"Ogino Hirokazu"},{"name":"Hanibuchi Masaki"},{"name":"Takizawa Hiromitsu"},{"name":"Sakiyama Shoji"},{"name":"Hiroyuki Sumitomo"},{"name":"Iwamoto Seiji"},{"name":"Ikushima Hitoshi"},{"name":"Kohei Nakajima"},{"name":"Nagahiro Shinji"},{"name":"Taito Yamago"},{"name":"Toyoda Yuko"},{"name":"Bando Yoshimi"},{"name":"Nishioka Yasuhiko"}],"ja":[{"name":"荻野 広和"},{"name":"埴淵 昌毅"},{"name":"滝沢 宏光"},{"name":"先山 正二"},{"name":"Hiroyuki Sumitomo"},{"name":"岩本 誠司"},{"name":"生島 仁史"},{"name":"Kohei Nakajima"},{"name":"永廣 信治"},{"name":"Taito Yamago"},{"name":"豊田 優子"},{"name":"坂東 良美"},{"name":"西岡 安彦"}]},"description":{"en":"A 54-year-old man was referred to our hospital due to a mass shadow noted on a chest X-ray. Thoracoscopic lobectomy yielded a diagnosis of primary pulmonary synovial sarcoma according to the histology and SYT-SSX1 gene analyses. Five months after the thoracic surgery, he developed brain metastasis; therefore, we performed resection of the brain metastatic focus followed by radiotherapy. As a local recurrence in the thoracic cavity concurrently emerged, systemic chemotherapy was also administered. These observations indicated that a multidisciplinary approach may be useful against primary pulmonary synovial sarcoma, although there is presently no established therapeutic strategy due to its rarity and highly aggressive nature.","ja":"A 54-year-old man was referred to our hospital due to a mass shadow noted on a chest X-ray. Thoracoscopic lobectomy yielded a diagnosis of primary pulmonary synovial sarcoma according to the histology and SYT-SSX1 gene analyses. Five months after the thoracic surgery, he developed brain metastasis; therefore, we performed resection of the brain metastatic focus followed by radiotherapy. As a local recurrence in the thoracic cavity concurrently emerged, systemic chemotherapy was also administered. These observations indicated that a multidisciplinary approach may be useful against primary pulmonary synovial sarcoma, although there is presently no established therapeutic strategy due to its rarity and highly aggressive nature."},"publication_date":"2016-02-15","publication_name":{"en":"Internal Medicine","ja":"Internal Medicine"},"volume":"Vol.55","number":"No.4","starting_page":"381","ending_page":"387","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2169/internalmedicine.55.5169"],"issn":["1349-7235"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/111180","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/27644557","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-84987887510&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=323810","label":"url"}],"paper_title":{"en":"Thirty percent of ductal carcinoma in situ of the breast in Japan is extremely low-grade ER(+)/HER2(-) type without comedo necrosis","ja":"Thirty percent of ductal carcinoma in situ of the breast in Japan is extremely low-grade ER(+)/HER2(-) type without comedo necrosis"},"authors":{"en":[{"name":"Kanematsu Miyuki"},{"name":"Morimoto Masami"},{"name":"Takahashi Masako"},{"name":"Honda Junko"},{"name":"Bando Yoshimi"},{"name":"Moriya Takuya"},{"name":"Tadokoro Yukiko"},{"name":"Nakagawa Misako"},{"name":"Takechi Hirokazu"},{"name":"Yoshida Takahiro"},{"name":"Toba Hiroaki"},{"name":"Yoshida Mitsuteru"},{"name":"Kajikawa Aiichiro"},{"name":"Tangoku Akira"},{"name":"Imoto Issei"},{"name":"Sasa Mitsunori"}],"ja":[{"name":"兼松 美幸"},{"name":"森本 雅美"},{"name":"高橋 雅子"},{"name":"本田 純子"},{"name":"坂東 良美"},{"name":"Moriya Takuya"},{"name":"田所 由紀子"},{"name":"中川 美砂子"},{"name":"武知 浩和"},{"name":"吉田 卓弘"},{"name":"鳥羽 博明"},{"name":"吉田 光輝"},{"name":"梶川 愛一郎"},{"name":"丹黒 章"},{"name":"井本 逸勢"},{"name":"笹 三徳"}]},"description":{"en":"Background Overdiagnosis in mammography (MMG) is a problem. Combination of MMG and ultrasonography for breast cancer screening may increase overdiagnosis. Most cases of overdiagnosis are low-grade ductal carcinoma in situ (LGD), but no reports have focused on them. Materials and methods We immunostained 169 ductal carcinoma in situ (DCIS) cases for ER, PgR, HER2 and Ki67 and classified them into 4 subtypes: ER(+)/HER2(-), ER(+)/HER2(+), ER(-)/HER2(-) and ER(-)/HER2(+). The Ki67 index was used to evaluate the grade of malignancy and examined for correlations with each ER/HER2 subtype and the nuclear grade (NG), with/without comedo necrosis. Results The Ki67 index correlated significantly with NG, both with/without comedo necrosis, and reliably evaluated the grade of malignancy. The index for ER(+)/HER2(-) (n=117, 69.2%) was 7.45±7.10, which was significantly lower than for each of the other types. The index was 5.71±6.94 for ER(+)/HER2(-) without comedo necrosis (n=52, 30.8%), which was significantly lower than with comedo necrosis. This was considered LGD, characterized by absence of microcalcification in MMG and either presence of a solid mass or cystic lesion or absence of hypoechoic areas in ultrasound. Conclusion In Japan, ER(+)/HER2(-) without comedo necrosis accounts for about 30% of DCIS and is LGD. This may be being overdiagnosed. J. Med. Invest. 63: 192-198, August, 2016.","ja":"Background Overdiagnosis in mammography (MMG) is a problem. Combination of MMG and ultrasonography for breast cancer screening may increase overdiagnosis. Most cases of overdiagnosis are low-grade ductal carcinoma in situ (LGD), but no reports have focused on them. Materials and methods We immunostained 169 ductal carcinoma in situ (DCIS) cases for ER, PgR, HER2 and Ki67 and classified them into 4 subtypes: ER(+)/HER2(-), ER(+)/HER2(+), ER(-)/HER2(-) and ER(-)/HER2(+). The Ki67 index was used to evaluate the grade of malignancy and examined for correlations with each ER/HER2 subtype and the nuclear grade (NG), with/without comedo necrosis. Results The Ki67 index correlated significantly with NG, both with/without comedo necrosis, and reliably evaluated the grade of malignancy. The index for ER(+)/HER2(-) (n=117, 69.2%) was 7.45±7.10, which was significantly lower than for each of the other types. The index was 5.71±6.94 for ER(+)/HER2(-) without comedo necrosis (n=52, 30.8%), which was significantly lower than with comedo necrosis. This was considered LGD, characterized by absence of microcalcification in MMG and either presence of a solid mass or cystic lesion or absence of hypoechoic areas in ultrasound. Conclusion In Japan, ER(+)/HER2(-) without comedo necrosis accounts for about 30% of DCIS and is LGD. This may be being overdiagnosed. J. Med. Invest. 63: 192-198, August, 2016."},"publication_date":"2016","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.63","number":"No.3-4","starting_page":"192","ending_page":"198","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.63.192"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/25867231","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=298999","label":"url"}],"paper_title":{"en":"Henoch-Schönlein purpura nephritis occurring postpartum in a patient with anti-PL-7 anti-synthetase syndrome.","ja":"Henoch-Schönlein purpura nephritis occurring postpartum in a patient with anti-PL-7 anti-synthetase syndrome."},"authors":{"en":[{"name":"Nagai Kojiro"},{"name":"Kishi Jun"},{"name":"Morizumi Shun"},{"name":"Minakuchi Jun"},{"name":"Bando Yoshimi"},{"name":"Nishioka Yasuhiko"},{"name":"Doi Toshio"}],"ja":[{"name":"長井 幸二郎"},{"name":"岸 潤"},{"name":"Morizumi Shun"},{"name":"Minakuchi Jun"},{"name":"坂東 良美"},{"name":"西岡 安彦"},{"name":"土井 俊夫"}]},"description":{"en":"A 37-year-old pregnant woman developed purpura which was subsequently diagnosed as Henoch-Schönlein purpura (HSP). After childbirth, the patient developed proteinuria and hematuria. Further examination revealed that the HSP nephritis (HSPN) was associated with anti-threonyl-tRNA synthetase anti-synthetase syndrome. The onset of HSPN during pregnancy or after childbirth is rare. Moreover, to our knowledge, this is the first case to describe renal involvement in anti-synthetase syndrome.","ja":"A 37-year-old pregnant woman developed purpura which was subsequently diagnosed as Henoch-Schönlein purpura (HSP). After childbirth, the patient developed proteinuria and hematuria. Further examination revealed that the HSP nephritis (HSPN) was associated with anti-threonyl-tRNA synthetase anti-synthetase syndrome. The onset of HSPN during pregnancy or after childbirth is rare. Moreover, to our knowledge, this is the first case to describe renal involvement in anti-synthetase syndrome."},"publication_date":"2015-05-28","publication_name":{"en":"Modern Rheumatology","ja":"Modern Rheumatology"},"volume":"Vol.28","starting_page":"1","ending_page":"4","languages":["eng"],"referee":true,"identifiers":{"doi":["10.3109/14397595.2015.1038879"],"issn":["1439-7609"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/114526","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/25808597","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-84925679901&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=300310","label":"url"}],"paper_title":{"en":"Immunocytochemical results for HER2 and Ki67 in breast cancer touch-smear cell specimens are reliable.","ja":"Immunocytochemical results for HER2 and Ki67 in breast cancer touch-smear cell specimens are reliable."},"authors":{"en":[{"name":"Morimoto Masami"},{"name":"Bando Yoshimi"},{"name":"Nakagawa Misako"},{"name":"Takechi Hirokazu"},{"name":"Yoshida Takahiro"},{"name":"Honda Junko"},{"name":"Tadokoro Yukiko"},{"name":"Moriya Takuya"},{"name":"Sasa Mitsunori"},{"name":"Tangoku Akira"}],"ja":[{"name":"Morimoto Masami"},{"name":"坂東 良美"},{"name":"中川 美砂子"},{"name":"武知 浩和"},{"name":"吉田 卓弘"},{"name":"本田 純子"},{"name":"田所 由紀子"},{"name":"Moriya Takuya"},{"name":"Sasa Mitsunori"},{"name":"丹黒 章"}]},"description":{"en":"The reliability of ICC analysis of HER2 expression and the Ki67 index using TSC were recognized.","ja":"HER2 and Ki67 were analyzed in TSC from 36 and 28 patients, respectively. The HER2 expression scores in the TSC and HS groups showed good agreement (kappa value =0.640) and significant correlation (correlation coefficient =0.860, p < 0.001). The Ki67 indexes in the TSC and HS groups also showed significant correlation (correlation coefficient =0.861, p < 0.001)."},"publication_date":"2015-03-26","publication_name":{"en":"Breast Cancer","ja":"Breast Cancer"},"volume":"Vol.23","number":"No.4","starting_page":"577","ending_page":"582","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s12282-015-0605-z"],"issn":["1880-4233"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/25734803","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-84930007610&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=294304","label":"url"}],"paper_title":{"en":"Epidermoid metaplasia of the esophagus with an unusual appearance on magnification.","ja":"Epidermoid metaplasia of the esophagus with an unusual appearance on magnification."},"authors":{"en":[{"name":"Kitamura Shinji"},{"name":"Okada Yasuyuki"},{"name":"Muguruma Naoki"},{"name":"Miyamoto Hiroshi"},{"name":"Bando Yoshimi"},{"name":"Aoki Rika"},{"name":"Takayama Tetsuji"}],"ja":[{"name":"北村 晋志"},{"name":"Okada Yasuyuki"},{"name":"六車 直樹"},{"name":"宮本 弘志"},{"name":"坂東 良美"},{"name":"Aoki Rika"},{"name":"高山 哲治"}]},"publication_date":"2015-03-03","publication_name":{"en":"Endoscopy","ja":"Endoscopy"},"volume":"Vol.47","number":"No.S1","starting_page":"E100","ending_page":"E100","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1055/s-0034-1391299"],"issn":["1438-8812"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/25605315","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-84925493491&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=289423","label":"url"}],"paper_title":{"en":"Insulin-like growth factor II-producing metastatic colon cancer with recurrent hypoglycemia.","ja":"Insulin-like growth factor II-producing metastatic colon cancer with recurrent hypoglycemia."},"authors":{"en":[{"name":"Teramae Satoshi"},{"name":"Miyamoto Hiroshi"},{"name":"Muguruma Naoki"},{"name":"Okada Yasuyuki"},{"name":"Goji Takahiro"},{"name":"Kitamura Shinji"},{"name":"Kimura Tetsuo"},{"name":"Kimura Masako"},{"name":"Bando Yoshimi"},{"name":"Takayama Tetsuji"}],"ja":[{"name":"Teramae Satoshi"},{"name":"宮本 弘志"},{"name":"六車 直樹"},{"name":"Okada Yasuyuki"},{"name":"郷司 敬洋"},{"name":"北村 晋志"},{"name":"木村 哲夫"},{"name":"木村 雅子"},{"name":"坂東 良美"},{"name":"高山 哲治"}]},"description":{"en":"A 45-year-old man was referred to our hospital and found to have a tubular adenocarcinoma of the descending colon with multiple liver metastases. During hospitalization, the patient suffered recurrent hypoglycemic attacks that required intravenous 50% glucose infusion. He was diagnosed with non-islet cell tumor hypoglycemia (NICTH) because the colon cancer tissue obtained by biopsy was strongly stained for insulin-like growth factor-II (IGF-II) by immunohistochemistry. He received chemotherapy with oxaliplatin, 5-FU and leucovorin (FOLFOX) plus bevacizumab (Bmab), and showed a partial response. As the metastatic lesions decreased in size, the hypoglycemic attacks gradually disappeared. Subsequently, he received outpatient chemotherapy and maintained a high quality of life for about 10 months. Western blot analysis of IGF-II in serum at the time of admission showed a high-molecular-weight form of IGF-II, which was considered to have caused hypoglycemia. This patient presents a very rare case of colorectal cancer associated with NICTH syndrome due to production of high-molecular-weight IGF-II by cancer cells. It is important to investigate IGF-II expression in cancer tissues for establishing the diagnosis of NICTH in cases with intractable hypoglycemia complicated by advanced cancer.","ja":"A 45-year-old man was referred to our hospital and found to have a tubular adenocarcinoma of the descending colon with multiple liver metastases. During hospitalization, the patient suffered recurrent hypoglycemic attacks that required intravenous 50% glucose infusion. He was diagnosed with non-islet cell tumor hypoglycemia (NICTH) because the colon cancer tissue obtained by biopsy was strongly stained for insulin-like growth factor-II (IGF-II) by immunohistochemistry. He received chemotherapy with oxaliplatin, 5-FU and leucovorin (FOLFOX) plus bevacizumab (Bmab), and showed a partial response. As the metastatic lesions decreased in size, the hypoglycemic attacks gradually disappeared. Subsequently, he received outpatient chemotherapy and maintained a high quality of life for about 10 months. Western blot analysis of IGF-II in serum at the time of admission showed a high-molecular-weight form of IGF-II, which was considered to have caused hypoglycemia. This patient presents a very rare case of colorectal cancer associated with NICTH syndrome due to production of high-molecular-weight IGF-II by cancer cells. It is important to investigate IGF-II expression in cancer tissues for establishing the diagnosis of NICTH in cases with intractable hypoglycemia complicated by advanced cancer."},"publication_date":"2015-02","publication_name":{"en":"Clinical Journal of Gastroenterology","ja":"Clinical Journal of Gastroenterology"},"volume":"Vol.8","number":"No.1","starting_page":"35","ending_page":"40","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s12328-015-0552-4"],"issn":["1865-7265"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://ci.nii.ac.jp/naid/130004470997/","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/24990463","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1390282680171447808/","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-84920870427&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=279140","label":"url"}],"paper_title":{"en":"Magnetic Resonance Manifestations of Villoglandular Papillary Adenocarcinoma of the Uterine Cervix with a Fern-leaf-like Appearance.","ja":"Magnetic Resonance Manifestations of Villoglandular Papillary Adenocarcinoma of the Uterine Cervix with a Fern-leaf-like Appearance."},"authors":{"en":[{"name":"Takeuchi Mayumi"},{"name":"Matsuzaki Kenji"},{"name":"Bando Yoshimi"},{"name":"Sakaki Mika"},{"name":"Furumoto Hiroyuki"},{"name":"Harada Masafumi"}],"ja":[{"name":"竹内 麻由美"},{"name":"松崎 健司"},{"name":"坂東 良美"},{"name":"榊 美佳"},{"name":"古本 博孝"},{"name":"原田 雅史"}]},"description":{"en":"Villoglandular papillary adenocarcinoma (VGPA) is a rare subtype of cervical adenocarcinoma that generally affects young women and has a favorable prognosis. Its preoperative diagnosis is important to avoid excessive surgery. We report the magnetic resonance (MR) findings of a case in which the cervical tumor showed a fern-leaf-like appearance on high resolution T2-weighted images obtained at 3 tesla. MR imaging clearly showed this pathological feature that may suggest this disease.","ja":"Villoglandular papillary adenocarcinoma (VGPA) is a rare subtype of cervical adenocarcinoma that generally affects young women and has a favorable prognosis. Its preoperative diagnosis is important to avoid excessive surgery. We report the magnetic resonance (MR) findings of a case in which the cervical tumor showed a fern-leaf-like appearance on high resolution T2-weighted images obtained at 3 tesla. MR imaging clearly showed this pathological feature that may suggest this disease."},"publication_date":"2014-07-02","publication_name":{"en":"Magnetic Resonance in Medical Sciences","ja":"Magnetic Resonance in Medical Sciences"},"volume":"Vol.13","number":"No.4","starting_page":"267","ending_page":"270","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2463/mrms.2013-0078"],"issn":["1880-2206"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"http://repo.lib.tokushima-u.ac.jp/109897","label":"url"},{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/109897","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1050282812441738752/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=302029","label":"url"}],"paper_title":{"en":"Support System for Women Doctors by Tokushima City Medical Association","ja":"徳島市医師会の女性医師支援事業"},"authors":{"en":[{"name":"坂東 智子"},{"name":"Akaike Masashi"},{"name":"鶴尾 美穂"},{"name":"石本 寛子"},{"name":"宮内 和瑞"},{"name":"Bando Yoshimi"},{"name":"生島 葉子"},{"name":"宮 恵子"},{"name":"瀧 雅"},{"name":"原田 和代"},{"name":"角瀬 裕子"},{"name":"豊崎 纏"}],"ja":[{"name":"坂東 智子"},{"name":"赤池 雅史"},{"name":"鶴尾 美穂"},{"name":"石本 寛子"},{"name":"宮内 和瑞"},{"name":"坂東 良美"},{"name":"生島 葉子"},{"name":"宮 恵子"},{"name":"瀧 雅"},{"name":"原田 和代"},{"name":"角瀬 裕子"},{"name":"豊崎 纏"}]},"description":{"en":"In recent years, an increase in the ratio of female physicians in Tokushima Prefecture, with a particularly notable rise among younger generations that has exceeded the national average, has been observed. However, these physicians continue to face severe working environments, and support measures are required for female physicians during childbirth and in the early stages of parenthood. To this end, the Tokushima City Medical Association has been involved in initiatives to support female physicians since 2008. First, we developed ``Net Joy,'' a website that provides the information necessary for female physicians to continue their clinical work through a bulletin board system that offers information on topics such as employment and childcare. Furthermore, we have administered questionnaire surveys related to working environments and support systems in clinical training hospitals and compiled a booklet entitled Support Notebook for Female Physicians that is available on the Net Joy website. Since 2011, as post-residency training in ultrasound techniques, we have held six separate practical training seminars at the Tokushima University Hospital Ultrasound Examination Center and the Tokushima City Medical Association Hall. Since 2014, we have been involved in efforts to enhance its training content and develop it into a long-term program.","ja":"In recent years, an increase in the ratio of female physicians in Tokushima Prefecture, with a particularly notable rise among younger generations that has exceeded the national average, has been observed. However, these physicians continue to face severe working environments, and support measures are required for female physicians during childbirth and in the early stages of parenthood. To this end, the Tokushima City Medical Association has been involved in initiatives to support female physicians since 2008. First, we developed ``Net Joy,'' a website that provides the information necessary for female physicians to continue their clinical work through a bulletin board system that offers information on topics such as employment and childcare. Furthermore, we have administered questionnaire surveys related to working environments and support systems in clinical training hospitals and compiled a booklet entitled Support Notebook for Female Physicians that is available on the Net Joy website. Since 2011, as post-residency training in ultrasound techniques, we have held six separate practical training seminars at the Tokushima University Hospital Ultrasound Examination Center and the Tokushima City Medical Association Hall. Since 2014, we have been involved in efforts to enhance its training content and develop it into a long-term program."},"publication_date":"2014-05","publication_name":{"en":"Shikoku Acta Medica","ja":"四国医学雑誌"},"volume":"Vol.70","number":"No.5-6","starting_page":"161","ending_page":"166","languages":["jpn"],"referee":true,"identifiers":{"issn":["0037-3699"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/106141","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/24705763","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=284297","label":"url"}],"paper_title":{"en":"Comparing the performance of visual estimation and standard uptake value of F-18 fluorodeoxyglucose positron emission tomography/computed tomography for detecting malignancy in pancreatic tumors other than invasive ductal carcinoma.","ja":"Comparing the performance of visual estimation and standard uptake value of F-18 fluorodeoxyglucose positron emission tomography/computed tomography for detecting malignancy in pancreatic tumors other than invasive ductal carcinoma."},"authors":{"en":[{"name":"Otomi Youichi"},{"name":"Otsuka Hideki"},{"name":"Terazawa Kaori"},{"name":"Nose Hayato"},{"name":"Kubo Michiko"},{"name":"Matsuzaki Kenji"},{"name":"Ikushima Hitoshi"},{"name":"Bando Yoshimi"},{"name":"Harada Masafumi"}],"ja":[{"name":"音見 暢一"},{"name":"大塚 秀樹"},{"name":"Terazawa Kaori"},{"name":"能勢 隼人"},{"name":"久保 典子"},{"name":"松崎 健司"},{"name":"生島 仁史"},{"name":"坂東 良美"},{"name":"原田 雅史"}]},"description":{"en":"The utility of FDG PET/CT for the detection and evaluation of invasive ductal carcinoma has been widely reported, but a few studies have assessed the utility of FDG PET/CT to detect malignancy in a variety of pancreatic lesions other than invasive ductal carcinoma. To compare the diagnostic performance of visual estimation with the semi-quantitative scores of FDG PET/CT for detecting malignancy in a variety of pancreatic lesions other than invasive ductal carcinoma. Images of pathologically proven pancreatic lesions from 32 patients were retrospectively evaluated: 14 benign lesions, 7 borderline (low malignant) lesions, and 11 malignant lesions. The average scores from visual estimation by the two observers were compared to two semi-quantitative analyses of FDG uptake in the lesions, namely the maximum standardized uptake value (SUVmax) and mean standardized uptake value (SUVmean). Visual analysis value, SUVmax and SUVmean were 0.33 ± 0.21, 1.8 ± 0.7 and 1.5 ± 0.7 for the benign lesions, 0.70 ± 0.28, 5.0 ± 2.6 and 3.1±1.7 for the borderline lesions, and 0.73 ± 0.18, 4.7 ± 2.5 and 3.2 ± 1.6 for the malignant lesions, respectively. Receiver operating characteristic analysis revealed the areas under the curves for detecting non-benign (malignant or borderline) lesions through visual analysis, SUVmax, and SUVmean were 0.914, 0.954, and 0.875, respectively. For a variety of pancreatic lesions other than invasive ductal carcinoma, visual analysis and semi-quantitative analyses all showed strong diagnostic performance. However, semi-quantitative analysis with SUVmax proved to be the most effective method for detecting non-benign pancreatic lesions.","ja":"The utility of FDG PET/CT for the detection and evaluation of invasive ductal carcinoma has been widely reported, but a few studies have assessed the utility of FDG PET/CT to detect malignancy in a variety of pancreatic lesions other than invasive ductal carcinoma. To compare the diagnostic performance of visual estimation with the semi-quantitative scores of FDG PET/CT for detecting malignancy in a variety of pancreatic lesions other than invasive ductal carcinoma. Images of pathologically proven pancreatic lesions from 32 patients were retrospectively evaluated: 14 benign lesions, 7 borderline (low malignant) lesions, and 11 malignant lesions. The average scores from visual estimation by the two observers were compared to two semi-quantitative analyses of FDG uptake in the lesions, namely the maximum standardized uptake value (SUVmax) and mean standardized uptake value (SUVmean). Visual analysis value, SUVmax and SUVmean were 0.33 ± 0.21, 1.8 ± 0.7 and 1.5 ± 0.7 for the benign lesions, 0.70 ± 0.28, 5.0 ± 2.6 and 3.1±1.7 for the borderline lesions, and 0.73 ± 0.18, 4.7 ± 2.5 and 3.2 ± 1.6 for the malignant lesions, respectively. Receiver operating characteristic analysis revealed the areas under the curves for detecting non-benign (malignant or borderline) lesions through visual analysis, SUVmax, and SUVmean were 0.914, 0.954, and 0.875, respectively. For a variety of pancreatic lesions other than invasive ductal carcinoma, visual analysis and semi-quantitative analyses all showed strong diagnostic performance. However, semi-quantitative analysis with SUVmax proved to be the most effective method for detecting non-benign pancreatic lesions."},"publication_date":"2014","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.61","number":"No.1-2","starting_page":"171","ending_page":"179","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.61.171"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/23432631","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=274179","label":"url"}],"paper_title":{"en":"Prevalence and characteristics of nodular gastritis in Japanese elderly.","ja":"Prevalence and characteristics of nodular gastritis in Japanese elderly."},"authors":{"en":[{"name":"Kitamura Shinji"},{"name":"Yasuda Mitsugi"},{"name":"Muguruma Naoki"},{"name":"Okamoto Koichi"},{"name":"Takeuchi Hisashi"},{"name":"Bando Yoshimi"},{"name":"Miyamoto Hiroshi"},{"name":"Okahisa Toshiya"},{"name":"Yano Mitsuyasu"},{"name":"Torisu Ryusuke"},{"name":"Takayama Tetsuji"}],"ja":[{"name":"北村 晋志"},{"name":"Yasuda Mitsugi"},{"name":"六車 直樹"},{"name":"岡本 耕一"},{"name":"Takeuchi Hisashi"},{"name":"坂東 良美"},{"name":"宮本 弘志"},{"name":"岡久 稔也"},{"name":"Yano Mitsuyasu"},{"name":"Torisu Ryusuke"},{"name":"高山 哲治"}]},"description":{"en":"NG in the elderly was also suggested to be a risk factor for gastric cancer as well as in the young.","ja":"NG was found in 62 cases (0.94%) out of 6623 patients who underwent endoscopy, with a mean age of 47.3 ± 13.3 years. Female patients were present at a significantly higher rate in the elderly group (P < 0.001). The grade of neutrophil infiltration in the greater curvature of the upper gastric body was recognized at a significantly higher rate in the elderly group (P < 0.05). PG II was present at a higher rate and PG I/II at a lower rate in the elderly group (P < 0.05). The odds ratio for the risk of gastric cancer in patients with NG was 2.1 (95% confidence interval 0.3-15.3) in the elderly group."},"publication_date":"2013-07","publication_name":{"en":"Journal of Gastroenterology and Hepatology","ja":"Journal of Gastroenterology and Hepatology"},"volume":"Vol.28","number":"No.7","starting_page":"1154","ending_page":"1160","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1111/jgh.12180"],"issn":["1440-1746"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/23674658","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=264177","label":"url"}],"paper_title":{"en":"18F-fluorodeoxyglucose positron emission tomography/computed tomography and the relationship between fluorodeoxyglucose uptake and the expression of hypoxia-inducible factor-1, glucose transporter-1 and vascular endothelial growth factor in thymic epithelial tumours.","ja":"18F-fluorodeoxyglucose positron emission tomography/computed tomography and the relationship between fluorodeoxyglucose uptake and the expression of hypoxia-inducible factor-1, glucose transporter-1 and vascular endothelial growth factor in thymic epithelial tumours."},"authors":{"en":[{"name":"Toba Hiroaki"},{"name":"Kondo Kazuya"},{"name":"Sadohara Yohei"},{"name":"Otsuka Hideki"},{"name":"Morimoto Masami"},{"name":"Kajiura Koichiro"},{"name":"Nakagawa Yasushi"},{"name":"Yoshida Mitsuteru"},{"name":"Kawakami Yukikiyo"},{"name":"Takizawa Hiromitsu"},{"name":"Kenzaki Koichiro"},{"name":"Sakiyama Shoji"},{"name":"Bando Yoshimi"},{"name":"Tangoku Akira"}],"ja":[{"name":"鳥羽 博明"},{"name":"近藤 和也"},{"name":"Sadohara Yohei"},{"name":"大塚 秀樹"},{"name":"Morimoto Masami"},{"name":"梶浦 耕一郎"},{"name":"中川 靖士"},{"name":"吉田 光輝"},{"name":"川上 行奎"},{"name":"滝沢 宏光"},{"name":"監﨑 孝一郎"},{"name":"先山 正二"},{"name":"坂東 良美"},{"name":"丹黒 章"}]},"description":{"en":"OBJECTIVES: The objective of this study was to evaluate the usefulness of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) and the relationships among the expressions of hypoxia-inducible factor-1 (HIF-1), glucose transporter-1 (Glut-1) and vascular endothelial growth factor (VEGF), histological type, other clinical factors and FDG uptake in thymic epithelial tumours. METHODS: Thirty-three patients who underwent FDG-PET/CT before treatment were reviewed. All types of tumours were reclassified into three subgroups: low-risk thymomas (types A, AB and B1), high-risk thymomas (types B2 and B3) and thymic carcinomas. Tumour contour, pattern of FDG uptake, tumour size and maximum standardized uptake value (SUVmax) were obtained. Expressions of HIF-1, Glut-1 and VEGF were analysed immunohistochemically, and these expressions were evaluated using grading scales. RESULTS: FDG uptake was visually recognized in all (100%) tumours. A homogeneous pattern of FDG uptake was increasingly observed in the order of low-risk thymomas to high-risk thymomas to thymic carcinomas (P = 0.016). SUVmax for thymic carcinomas was significantly higher than that for thymomas (P = 0.008). With the optimal cut-off value of SUVmax of 5.6, the sensitivity, specificity and accuracy for diagnosing thymic carcinoma were 0.75, 0.80 and 0.79, respectively. Regarding the mean scoring of HIF-1, Glut-1 and VEGF, increasing trends were observed in the order of low-risk thymomas to high-risk thymomas to thymic carcinomas. Tumour size revealed a significant correlation with SUVmax (r = 0.60, P < 0.001), and the expression of HIF-1 showed a moderate association, but the expression of Glut-1 showed no correlation with SUVmax. Regarding correlations between the expression of the three markers, there were moderate associations between HIF-1 and Glut-1, and HIF-1 and VEGF, and a significant correlation between Glut-1 and VEGF (r = 0.60, P < 0.001). In type B1 thymoma, HIF-1 and Glut-1 were partly expressed in non-neoplastic immature lymphocytes. CONCLUSIONS: FDG-PET/CT should be performed in patients with tumours in the anterior mediastinum because the pattern of FDG uptake and SUVmax are useful in the differential diagnosis of thymic epithelial tumours. Furthermore, the expressions of HIF-1, Glut-1 and VEGF might be associated with malignancy of thymic epithelial tumours. In contrast, FDG uptake might be dependent on tumour size rather than Glut-1 overexpression.","ja":"OBJECTIVES: The objective of this study was to evaluate the usefulness of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) and the relationships among the expressions of hypoxia-inducible factor-1 (HIF-1), glucose transporter-1 (Glut-1) and vascular endothelial growth factor (VEGF), histological type, other clinical factors and FDG uptake in thymic epithelial tumours. METHODS: Thirty-three patients who underwent FDG-PET/CT before treatment were reviewed. All types of tumours were reclassified into three subgroups: low-risk thymomas (types A, AB and B1), high-risk thymomas (types B2 and B3) and thymic carcinomas. Tumour contour, pattern of FDG uptake, tumour size and maximum standardized uptake value (SUVmax) were obtained. Expressions of HIF-1, Glut-1 and VEGF were analysed immunohistochemically, and these expressions were evaluated using grading scales. RESULTS: FDG uptake was visually recognized in all (100%) tumours. A homogeneous pattern of FDG uptake was increasingly observed in the order of low-risk thymomas to high-risk thymomas to thymic carcinomas (P = 0.016). SUVmax for thymic carcinomas was significantly higher than that for thymomas (P = 0.008). With the optimal cut-off value of SUVmax of 5.6, the sensitivity, specificity and accuracy for diagnosing thymic carcinoma were 0.75, 0.80 and 0.79, respectively. Regarding the mean scoring of HIF-1, Glut-1 and VEGF, increasing trends were observed in the order of low-risk thymomas to high-risk thymomas to thymic carcinomas. Tumour size revealed a significant correlation with SUVmax (r = 0.60, P < 0.001), and the expression of HIF-1 showed a moderate association, but the expression of Glut-1 showed no correlation with SUVmax. Regarding correlations between the expression of the three markers, there were moderate associations between HIF-1 and Glut-1, and HIF-1 and VEGF, and a significant correlation between Glut-1 and VEGF (r = 0.60, P < 0.001). In type B1 thymoma, HIF-1 and Glut-1 were partly expressed in non-neoplastic immature lymphocytes. CONCLUSIONS: FDG-PET/CT should be performed in patients with tumours in the anterior mediastinum because the pattern of FDG uptake and SUVmax are useful in the differential diagnosis of thymic epithelial tumours. Furthermore, the expressions of HIF-1, Glut-1 and VEGF might be associated with malignancy of thymic epithelial tumours. In contrast, FDG uptake might be dependent on tumour size rather than Glut-1 overexpression."},"publication_date":"2013-05-14","publication_name":{"en":"European Journal of Cardio-Thoracic Surgery","ja":"European Journal of Cardio-Thoracic Surgery"},"volume":"Vol.44","number":"No.2","starting_page":"e105","ending_page":"e112","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1093/ejcts/ezt263"],"issn":["1873-734X"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"http://ci.nii.ac.jp/naid/40019562587/","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1522825130745084544/","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-84873164822&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=271456","label":"url"}],"paper_title":{"en":"The value of diagnostic imaging in neoadjuvant chemoradiation therapy for non-small cell lung cancer","ja":"非小細胞肺癌に対する術前導入化学放射線療法における画像診断の有用性"},"authors":{"en":[{"name":"Tanaka Yoshihiro"},{"name":"Ikushima Hitoshi"},{"name":"Kondo Kazuya"},{"name":"Kenzaki Koichiro"},{"name":"Bando Yoshimi"},{"name":"Otomi Youichi"},{"name":"Maezawa Hiroshi"}],"ja":[{"name":"田中 義浩"},{"name":"生島 仁史"},{"name":"近藤 和也"},{"name":"監﨑 孝一郎"},{"name":"坂東 良美"},{"name":"音見 暢一"},{"name":"前澤 博"}]},"publication_date":"2013-01","publication_name":{"en":"Japanese Journal of Clinical Radiology","ja":"(月刊)臨床放射線"},"volume":"Vol.58","number":"No.1","starting_page":"222","ending_page":"228","languages":["jpn"],"referee":true,"identifiers":{"issn":["0009-9252"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"http://ci.nii.ac.jp/naid/40019553441/","label":"url"},{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/110365","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1050282812441819136/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=264169","label":"url"}],"paper_title":{"en":"Erlotinibでinduction therapyを行ったIIIA期非小細胞肺癌の1手術例","ja":"Erlotinibでinduction therapyを行ったIIIA期非小細胞肺癌の1手術例"},"authors":{"en":[{"name":"坂本 晋一"},{"name":"Kajiura Koichiro"},{"name":"Takizawa Hiromitsu"},{"name":"Nakagawa Yasushi"},{"name":"池田 真由美"},{"name":"古川 尊子"},{"name":"森本 雅美"},{"name":"西野 豪志"},{"name":"Goto Masakazu"},{"name":"Nakagawa Misako"},{"name":"Yamamoto Yota"},{"name":"Furukita Yoshihito"},{"name":"Takechi Hirokazu"},{"name":"Yoshida Mitsuteru"},{"name":"Kawakami Yukikiyo"},{"name":"Tadokoro Yukiko"},{"name":"Sakiyama Shoji"},{"name":"Kondo Kazuya"},{"name":"Bando Yoshimi"},{"name":"岡崎 弘泰"},{"name":"Goto Hisatsugu"},{"name":"Nishioka Yasuhiko"},{"name":"Tangoku Akira"}],"ja":[{"name":"坂本 晋一"},{"name":"梶浦 耕一郎"},{"name":"滝沢 宏光"},{"name":"中川 靖士"},{"name":"池田 真由美"},{"name":"古川 尊子"},{"name":"森本 雅美"},{"name":"西野 豪志"},{"name":"後藤 正和"},{"name":"中川 美砂子"},{"name":"山本 洋太"},{"name":"古北 由仁"},{"name":"武知 浩和"},{"name":"吉田 光輝"},{"name":"川上 行奎"},{"name":"田所 由紀子"},{"name":"先山 正二"},{"name":"近藤 和也"},{"name":"坂東 良美"},{"name":"岡崎 弘泰"},{"name":"後東 久嗣"},{"name":"西岡 安彦"},{"name":"丹黒 章"}]},"publication_date":"2012-05","publication_name":{"en":"Shikoku Acta Medica","ja":"四国医学雑誌"},"volume":"Vol.68","number":"No.5-6","starting_page":"251","ending_page":"256","languages":["jpn"],"referee":true,"identifiers":{"issn":["0037-3699"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/22612511","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=270060","label":"url"}],"paper_title":{"en":"Autopsy case of amebic granulomatous meningoencephalitis caused by Balamuthia mandrillaris in Japan","ja":"Autopsy case of amebic granulomatous meningoencephalitis caused by Balamuthia mandrillaris in Japan"},"authors":{"en":[{"name":"Bando Yoshimi"},{"name":"Takahashi Tetsuyuki"},{"name":"Uehara Hisanori"},{"name":"Kageji Teruyoshi"},{"name":"Nagahiro Shinji"},{"name":"Izumi Keisuke"}],"ja":[{"name":"坂東 良美"},{"name":"髙橋 徹行"},{"name":"上原 久典"},{"name":"影治 照喜"},{"name":"永廣 信治"},{"name":"泉 啓介"}]},"description":{"en":"Balamuthia mandrillaris is a free-living ameba that causes amebic encephalitis. Herein, we report an autopsy case of Balamuthia encephalitis proven with polymerase chain reaction (PCR) and immunohistochemistry from paraffin-embedded brain biopsy specimens. A 68-year-old Japanese male presented at a hospital with progressive right hemiparesis approximately 3 months before his death. An open-brain biopsy specimen showed diffuse meningitis with massive coagulative necrosis. The perivascular spaces contained numerous lymphocytes, histiocytes and giant cells, although the etiology was not determined. The patient deteriorated into coma and died from cerebral herniation. Autopsy revealed abundant trophozoites and cysts in the subarachnoid and Virchow-Robin's spaces. Electron-micrographs of the amebic cysts showed a characteristic triple-walled envelope. The amebas were identified as Balamuthia mandrillaris based on immunohistochemical analysis from the autopsy and biopsy specimens. Primer sets designed to amplify approximately 200 bp bands of mitochondrial 16S rRNA gene of Balamuthia by PCR produced positive results from the biopsy specimens but negative results from the autopsy specimens. In summary, PCR to amplify shorter segments of DNA may be of diagnostic value in detecting suspected cases of balamuthiasis in formalin-fixed, paraffin-embedded specimens. Increased awareness and timely diagnosis of Balamuthia encephalitis might lead to earlier initiation of therapy and improved outcome.","ja":"Balamuthia mandrillaris is a free-living ameba that causes amebic encephalitis. Herein, we report an autopsy case of Balamuthia encephalitis proven with polymerase chain reaction (PCR) and immunohistochemistry from paraffin-embedded brain biopsy specimens. A 68-year-old Japanese male presented at a hospital with progressive right hemiparesis approximately 3 months before his death. An open-brain biopsy specimen showed diffuse meningitis with massive coagulative necrosis. The perivascular spaces contained numerous lymphocytes, histiocytes and giant cells, although the etiology was not determined. The patient deteriorated into coma and died from cerebral herniation. Autopsy revealed abundant trophozoites and cysts in the subarachnoid and Virchow-Robin's spaces. Electron-micrographs of the amebic cysts showed a characteristic triple-walled envelope. The amebas were identified as Balamuthia mandrillaris based on immunohistochemical analysis from the autopsy and biopsy specimens. Primer sets designed to amplify approximately 200 bp bands of mitochondrial 16S rRNA gene of Balamuthia by PCR produced positive results from the biopsy specimens but negative results from the autopsy specimens. In summary, PCR to amplify shorter segments of DNA may be of diagnostic value in detecting suspected cases of balamuthiasis in formalin-fixed, paraffin-embedded specimens. Increased awareness and timely diagnosis of Balamuthia encephalitis might lead to earlier initiation of therapy and improved outcome."},"publication_date":"2012-04-20","publication_name":{"en":"Pathology International","ja":"Pathology International"},"volume":"Vol.62","number":"No.6","starting_page":"418","ending_page":"423","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1111/j.1440-1827.2012.02816.x"],"issn":["1440-1827"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/21947696","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=258416","label":"url"}],"paper_title":{"en":"Prognosis of Esophageal Squamous Cell Carcinoma in Patients Positive for Human Epidermal Growth Factor Receptor Family Can Be Improved by Initial Chemotherapy with Docetaxel, Fluorouracil and Cisplatin","ja":"Prognosis of Esophageal Squamous Cell Carcinoma in Patients Positive for Human Epidermal Growth Factor Receptor Family Can Be Improved by Initial Chemotherapy with Docetaxel, Fluorouracil and Cisplatin"},"authors":{"en":[{"name":"Yamamoto Yota"},{"name":"Hiromichi Yamai"},{"name":"Seike Jun-ichi"},{"name":"Yoshida Takahiro"},{"name":"Takechi Hirokazu"},{"name":"Furukita Yoshihito"},{"name":"Kajiura Koichiro"},{"name":"Takuya Minato"},{"name":"Bando Yoshimi"},{"name":"Tangoku Akira"}],"ja":[{"name":"山本 洋太"},{"name":"Hiromichi Yamai"},{"name":"清家 純一"},{"name":"吉田 卓弘"},{"name":"武知 浩和"},{"name":"古北 由仁"},{"name":"梶浦 耕一郎"},{"name":"Takuya Minato"},{"name":"坂東 良美"},{"name":"丹黒 章"}]},"description":{"en":"The human epidermal growth factor receptor (HER) family, Ki-67 and p53 are important biomarkers for several malignancies. However, few studies have examined the role of these in prognosis and therapeutic sensitivity of esophageal squamous cell carcinoma (ESCC). The efficacy of triple-drug combination therapy with docetaxel, fluorouracil and cisplatin has recently been expected for ESCC. Subjects comprised 142 patients with ESCC who underwent operation (OP group, n = 54), neoadjuvant chemotherapy with docetaxel, fluorouracil, and cisplatin (DFP therapy) followed by operation (NAC group, n = 37) or initial systemic DFP therapy (CT group, n = 51) between January 2004 and December 2010. Immunohistochemical expressions of epidermal growth factor receptor (EGFR), HER2, HER3, Ki-67, and p53 were evaluated and compared with prognosis and sensitivity to DFP therapy. Positive correlations existed between EGFR, HER2, and HER3 expressions. In the OP group, EGFR was independently associated with postoperative recurrence in multivariate analysis (P = .036). In the NAC group, EGFR correlated with pathological response to DFP therapy (P = .004). In the CT group, EGFR, HER2, and HER3 correlated with clinical response to DFP therapy and EGFR was independently associated with favorable prognosis in multivariate analysis (P = .022). EGFR represents a predictor of postoperative recurrence and sensitivity to triple-drug combination therapy including a taxane. EGFR-positive patients may show improved prognosis with taxane combination chemotherapy and molecular targeted therapy for HER family members.","ja":"The human epidermal growth factor receptor (HER) family, Ki-67 and p53 are important biomarkers for several malignancies. However, few studies have examined the role of these in prognosis and therapeutic sensitivity of esophageal squamous cell carcinoma (ESCC). The efficacy of triple-drug combination therapy with docetaxel, fluorouracil and cisplatin has recently been expected for ESCC. Subjects comprised 142 patients with ESCC who underwent operation (OP group, n = 54), neoadjuvant chemotherapy with docetaxel, fluorouracil, and cisplatin (DFP therapy) followed by operation (NAC group, n = 37) or initial systemic DFP therapy (CT group, n = 51) between January 2004 and December 2010. Immunohistochemical expressions of epidermal growth factor receptor (EGFR), HER2, HER3, Ki-67, and p53 were evaluated and compared with prognosis and sensitivity to DFP therapy. Positive correlations existed between EGFR, HER2, and HER3 expressions. In the OP group, EGFR was independently associated with postoperative recurrence in multivariate analysis (P = .036). In the NAC group, EGFR correlated with pathological response to DFP therapy (P = .004). In the CT group, EGFR, HER2, and HER3 correlated with clinical response to DFP therapy and EGFR was independently associated with favorable prognosis in multivariate analysis (P = .022). EGFR represents a predictor of postoperative recurrence and sensitivity to triple-drug combination therapy including a taxane. EGFR-positive patients may show improved prognosis with taxane combination chemotherapy and molecular targeted therapy for HER family members."},"publication_date":"2012-03","publication_name":{"en":"Annals of Surgical Oncology","ja":"Annals of Surgical Oncology"},"volume":"Vol.19","number":"No.3","starting_page":"757","ending_page":"765","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1245/s10434-011-2071-y"],"issn":["1534-4681"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/22305550","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=258415","label":"url"}],"paper_title":{"en":"Implantation of fetal rat lung fragments into bleomycin-induced pulmonary fibrosis","ja":"Implantation of fetal rat lung fragments into bleomycin-induced pulmonary fibrosis"},"authors":{"en":[{"name":"Toba Hiroaki"},{"name":"Sakiyama Shoji"},{"name":"Kenzaki Koichiro"},{"name":"Kawakami Yukikiyo"},{"name":"Uyama Koh"},{"name":"Bando Yoshimi"},{"name":"Tangoku Akira"}],"ja":[{"name":"鳥羽 博明"},{"name":"先山 正二"},{"name":"監﨑 孝一郎"},{"name":"川上 行奎"},{"name":"Uyama Koh"},{"name":"坂東 良美"},{"name":"丹黒 章"}]},"description":{"en":"Pulmonary fibrosis is a life-threatening disease that results in progressive respiratory failure. We have suggested the possibility of fetal lung tissue as an option for further investigation into lung regeneration. The objective was to prove whether fetal lung fragments can survive and differentiate in fibrotic lung. Lewis rats were administered bleomycin and used as recipients after 3 or 4 weeks. Day 17 fetal lung tissue from green fluorescent protein Lewis rats was used as donor material. Donor lungs were removed, cut into small pieces, and implanted into the recipients' left lung. The recipients received cyclosporin to prevent immune response to green fluorescent protein and were killed after 1, 2, 4, 8, and 12 weeks and histologically evaluated. Furthermore, the expression of thyroid transcription factor-1 and Clara cell secretory protein in the implanted fetal lung tissue was immunohistologically evaluated. Fibrotic changes were recognized for a long period of time in the recipient lungs. The implanted fetal lung fragments could be clearly distinguished from recipient lungs because of the luminescence of grafts. Fetal lung fragments could survive in the recipient lungs with fibrotic changes. The air spaces of implanted fetal lungs were narrow at 1 and 2 weeks but expanded with the passage of time. The connection between the recipient lung and the implanted fetal lung was recognized, particularly in the peripheral grafts. The expression patterns of thyroid transcription factor-1 and Clara cell secretory protein in implanted lungs resembled those in the process of normal lung morphogenesis. Fetal rat lung fragments could survive and differentiate in bleomycin-induced completely fibrotic lung.","ja":"Pulmonary fibrosis is a life-threatening disease that results in progressive respiratory failure. We have suggested the possibility of fetal lung tissue as an option for further investigation into lung regeneration. The objective was to prove whether fetal lung fragments can survive and differentiate in fibrotic lung. Lewis rats were administered bleomycin and used as recipients after 3 or 4 weeks. Day 17 fetal lung tissue from green fluorescent protein Lewis rats was used as donor material. Donor lungs were removed, cut into small pieces, and implanted into the recipients' left lung. The recipients received cyclosporin to prevent immune response to green fluorescent protein and were killed after 1, 2, 4, 8, and 12 weeks and histologically evaluated. Furthermore, the expression of thyroid transcription factor-1 and Clara cell secretory protein in the implanted fetal lung tissue was immunohistologically evaluated. Fibrotic changes were recognized for a long period of time in the recipient lungs. The implanted fetal lung fragments could be clearly distinguished from recipient lungs because of the luminescence of grafts. Fetal lung fragments could survive in the recipient lungs with fibrotic changes. The air spaces of implanted fetal lungs were narrow at 1 and 2 weeks but expanded with the passage of time. The connection between the recipient lung and the implanted fetal lung was recognized, particularly in the peripheral grafts. The expression patterns of thyroid transcription factor-1 and Clara cell secretory protein in implanted lungs resembled those in the process of normal lung morphogenesis. Fetal rat lung fragments could survive and differentiate in bleomycin-induced completely fibrotic lung."},"publication_date":"2012-02-02","publication_name":{"en":"Journal of Thoracic and Cardiovascular Surgery","ja":"Journal of Thoracic and Cardiovascular Surgery"},"volume":"Vol.143","number":"No.6","starting_page":"1429","ending_page":"1435","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.jtcvs.2012.01.002"],"issn":["1097-685X"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/22847125","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-84871802319&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=255288","label":"url"}],"paper_title":{"en":"Aldehyde Dehydrogenase 1 Expression is Associated with Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma.","ja":"Aldehyde Dehydrogenase 1 Expression is Associated with Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma."},"authors":{"en":[{"name":"Minato Takuya"},{"name":"Yamamoto Yota"},{"name":"Seike Jun-ichi"},{"name":"Yoshida Takahiro"},{"name":"Yamai Hiromichi"},{"name":"Takechi Hirokazu"},{"name":"Yuasa Yasuhiro"},{"name":"Furukita Yoshihito"},{"name":"Goto Masakazu"},{"name":"Bando Yoshimi"},{"name":"Tangoku Akira"}],"ja":[{"name":"Minato Takuya"},{"name":"山本 洋太"},{"name":"清家 純一"},{"name":"吉田 卓弘"},{"name":"Yamai Hiromichi"},{"name":"武知 浩和"},{"name":"Yuasa Yasuhiro"},{"name":"古北 由仁"},{"name":"後藤 正和"},{"name":"坂東 良美"},{"name":"丹黒 章"}]},"description":{"en":"Aldehyde dehydrogenase 1 (ALDH1) and CD44 act as important biomarkers in several solid tumors. However, few studies have examined the relationships between ALDH1 expression and the prognosis and clinical characteristics of esophageal squamous cell carcinoma (ESCC). This study was a retrospective case-control study and included 152 patients with ESCC. A total of 56 patients underwent surgery (OP group), 40 patients received neoadjuvant chemotherapy involving weekly docetaxel plus 5-fluorouracil and low-dose cisplatin (DFP therapy) prior to undergoing surgery (NAC group), and 56 patients received initial systemic DFP therapy (CT group). The ALDH1 and CD44 immunohistochemical expression levels of each tumor were evaluated and compared with the prognosis and clinical characteristics of the ESCC patients. In the OP and NAC groups, multivariate analysis found that ALDH1 was independently associated with postoperative recurrence and prognosis (OP group, P=0.004 and 0.016, respectively; NAC group, P=0.026 and 0.014, respectively). In addition, CD44 was found to be associated with postoperative recurrence in the OP group and prognosis in the NAC group (P=0.024 and 0.047, respectively). Among the ALDH1-negative clinical stage II/III patients, the OP and NAC groups displayed better prognoses than the CT group (P<0.001). However, among the ALDH1-positive clinical stage II/III patients, the OP and NAC groups displayed poorer prognoses than the CT group (P=0.049). ALDH1 was found to be a predictor of postoperative recurrence and prognosis in ESCC, and CD44 might be a predictor of recurrence and prognosis. ALDH1 expression might affect the treatment strategy for ESCC.","ja":"BACKGROUND: Aldehyde dehydrogenase 1 (ALDH1) and CD44 act as important biomarkers in several solid tumors. However, few studies have examined the relationships between ALDH1 expression and the prognosis and clinical characteristics of esophageal squamous cell carcinoma (ESCC). METHODS: This study was a retrospective case-control study and included 152 patients with ESCC. A total of 56 patients underwent surgery (OP group), 40 patients received neoadjuvant chemotherapy involving weekly docetaxel plus 5-fluorouracil and low-dose cisplatin (DFP therapy) prior to undergoing surgery (NAC group), and 56 patients received initial systemic DFP therapy (CT group). The ALDH1 and CD44 immunohistochemical expression levels of each tumor were evaluated and compared with the prognosis and clinical characteristics of the ESCC patients. RESULTS: In the OP and NAC groups, multivariate analysis found that ALDH1 was independently associated with postoperative recurrence and prognosis (OP group, P = 0.004 and 0.016, respectively; NAC group, P = 0.026 and 0.014, respectively). In addition, CD44 was found to be associated with postoperative recurrence in the OP group and prognosis in the NAC group (P = 0.024 and 0.047, respectively). Among the ALDH1-negative clinical stage II/III patients, the OP and NAC groups displayed better prognoses than the CT group (P < 0.001). However, among the ALDH1-positive clinical stage II/III patients, the OP and NAC groups displayed poorer prognoses than the CT group (P = 0.049). CONCLUSIONS: ALDH1 was found to be a predictor of postoperative recurrence and prognosis in ESCC, and CD44 might be a predictor of recurrence and prognosis. ALDH1 expression might affect the treatment strategy for ESCC."},"publication_date":"2012-01","publication_name":{"en":"Annals of Surgical Oncology","ja":"Annals of Surgical Oncology"},"volume":"Vol.20","number":"No.1","starting_page":"209","ending_page":"217","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1245/s10434-012-2535-8"],"issn":["1534-4681"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/21763682","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=252145","label":"url"}],"paper_title":{"en":"Pleural mesothelioma instigates tumor-associated fibroblasts to promote progression via a malignant cytokine network.","ja":"Pleural mesothelioma instigates tumor-associated fibroblasts to promote progression via a malignant cytokine network."},"authors":{"en":[{"name":"Li Qi"},{"name":"Wang Wei"},{"name":"Yamada Tadaaki"},{"name":"Matsumoto Kunio"},{"name":"Sakai Katsuya"},{"name":"Bando Yoshimi"},{"name":"Uehara Hisanori"},{"name":"Nishioka Yasuhiko"},{"name":"Sone Saburo"},{"name":"Iwakiri Shotaro"},{"name":"Itoi Kazumi"},{"name":"Utsugi Teruhiro"},{"name":"Yasumoto Kazuo"},{"name":"Yano Seiji"}],"ja":[{"name":"Li Qi"},{"name":"Wang Wei"},{"name":"Yamada Tadaaki"},{"name":"Matsumoto Kunio"},{"name":"Sakai Katsuya"},{"name":"坂東 良美"},{"name":"上原 久典"},{"name":"西岡 安彦"},{"name":"曽根 三郎"},{"name":"Iwakiri Shotaro"},{"name":"Itoi Kazumi"},{"name":"Utsugi Teruhiro"},{"name":"Yasumoto Kazuo"},{"name":"Yano Seiji"}]},"description":{"en":"The tumor microenvironment is crucial to the progression of various malignancies. Malignant pleural mesothelioma (MPM), which originates from the pleura, grows aggressively in the thoracic cavity. Here we describe an orthotopic implantation SCID mouse model of MPM and demonstrate that α-SMA-positive fibroblast-like cells accumulate in the tumors produced by the human MPM cell lines MSTO-211H and Y-Meso-14. We assessed the interaction between MPM cells and their microenvironments, focusing on tumor-associated fibroblasts. MSTO-211H and Y-Meso-14 cells produced fibroblast growth factor-2 (FGF-2) and/or platelet-derived growth factor-AA (PDGF-AA); they also enhanced growth, migration, and production of hepatocyte growth factor (HGF) by human lung fibroblast MRC-5 cells. MRC-5 cells stimulated HGF-mediated growth and migration of MSTO-211H and Y-Meso-14 cells in an in vitro coculture system. In the orthotopic model, tumor formation by MSTO-211H and Y-Meso-14 cells was significantly inhibited by TSU-68, an inhibitor of FGF, VEGF, and PDGF receptors; imatinib, an inhibitor of PDGF receptors; and NK4, an antagonist of HGF. Histological analyses of clinical specimens from 51 MPM patients revealed considerable tumor-associated fibroblasts infiltration and expression of HGF, together with FGF-2 or PDGF-AA, in tumors. These findings indicate that MPM instigates tumor-associated fibroblasts, promoting tumor progression via a malignant cytokine network. Regulation of this cytokine network may be therapeutically useful for controlling MPM.","ja":"The tumor microenvironment is crucial to the progression of various malignancies. Malignant pleural mesothelioma (MPM), which originates from the pleura, grows aggressively in the thoracic cavity. Here we describe an orthotopic implantation SCID mouse model of MPM and demonstrate that α-SMA-positive fibroblast-like cells accumulate in the tumors produced by the human MPM cell lines MSTO-211H and Y-Meso-14. We assessed the interaction between MPM cells and their microenvironments, focusing on tumor-associated fibroblasts. MSTO-211H and Y-Meso-14 cells produced fibroblast growth factor-2 (FGF-2) and/or platelet-derived growth factor-AA (PDGF-AA); they also enhanced growth, migration, and production of hepatocyte growth factor (HGF) by human lung fibroblast MRC-5 cells. MRC-5 cells stimulated HGF-mediated growth and migration of MSTO-211H and Y-Meso-14 cells in an in vitro coculture system. In the orthotopic model, tumor formation by MSTO-211H and Y-Meso-14 cells was significantly inhibited by TSU-68, an inhibitor of FGF, VEGF, and PDGF receptors; imatinib, an inhibitor of PDGF receptors; and NK4, an antagonist of HGF. Histological analyses of clinical specimens from 51 MPM patients revealed considerable tumor-associated fibroblasts infiltration and expression of HGF, together with FGF-2 or PDGF-AA, in tumors. These findings indicate that MPM instigates tumor-associated fibroblasts, promoting tumor progression via a malignant cytokine network. Regulation of this cytokine network may be therapeutically useful for controlling MPM."},"publication_date":"2011-09-01","publication_name":{"en":"The American Journal of Pathology","ja":"The American Journal of Pathology"},"volume":"Vol.179","number":"No.3","starting_page":"1483","ending_page":"1493","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.ajpath.2011.05.060"],"issn":["1525-2191"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/21733044","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=247937","label":"url"}],"paper_title":{"en":"Inhibitory effect of soluble PDGFRbeta on intraosseous growth of breast cancer cells in nude mice","ja":"Inhibitory effect of soluble PDGFRbeta on intraosseous growth of breast cancer cells in nude mice"},"authors":{"en":[{"name":"Shan Hongchao"},{"name":"Takahashi Tetsuyuki"},{"name":"Bando Yoshimi"},{"name":"Izumi Keisuke"},{"name":"Uehara Hisanori"}],"ja":[{"name":"Shan Hongchao"},{"name":"髙橋 徹行"},{"name":"坂東 良美"},{"name":"泉 啓介"},{"name":"上原 久典"}]},"description":{"en":"Bone metastasis is a frequent complication of advanced breast cancer. On the basis of functional and molecular evidence, signaling mediated by the binding of platelet-derived growth factor (PDGF)-BB and -DD to PDGF receptor β (PDGFRβ) is critical for the survival and growth of metastatic breast cancer cells within the bone microenvironment. In this study, we propose a new approach to blocking PDGFRβ signaling using soluble PDGFRβ (sPDGFRβ) as a decoy receptor for PDGF-BB and -DD secreted from tumor cells and bone marrow stromal cells. A bone-seeking TNBCT/Bo cell line was established by in vivo selection from TNBCT human breast cancer cells, which are negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 protein expression. The TNBCT/Bo cells were transfected with a mammalian expression vector encoding the extracellular domain of PDGFRβ. A stable transfectant (TNBCT/Bo-sPDGFRβ) grew at a similar rate to that of control cells under normal culture conditions, although growth stimulation of human fibroblasts with PDGF-BB was neutralized by the culture medium from TNBCT/Bo-sPDGFRβ cells. Intratibial injection of TNBCT/Bo-sPDGFRβ cells into athymic nude mice resulted in a significant decrease in tumor incidence compared with control mice (P < 0.01). This attenuated growth correlated with decreased cancer cell proliferation, angiogenesis, and recruitment of stromal cells, and with an increase in the number of apoptotic cells. These findings suggest that sPDGFRβ is useful for the treatment of breast cancer bone metastasis.","ja":"Bone metastasis is a frequent complication of advanced breast cancer. On the basis of functional and molecular evidence, signaling mediated by the binding of platelet-derived growth factor (PDGF)-BB and -DD to PDGF receptor β (PDGFRβ) is critical for the survival and growth of metastatic breast cancer cells within the bone microenvironment. In this study, we propose a new approach to blocking PDGFRβ signaling using soluble PDGFRβ (sPDGFRβ) as a decoy receptor for PDGF-BB and -DD secreted from tumor cells and bone marrow stromal cells. A bone-seeking TNBCT/Bo cell line was established by in vivo selection from TNBCT human breast cancer cells, which are negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 protein expression. The TNBCT/Bo cells were transfected with a mammalian expression vector encoding the extracellular domain of PDGFRβ. A stable transfectant (TNBCT/Bo-sPDGFRβ) grew at a similar rate to that of control cells under normal culture conditions, although growth stimulation of human fibroblasts with PDGF-BB was neutralized by the culture medium from TNBCT/Bo-sPDGFRβ cells. Intratibial injection of TNBCT/Bo-sPDGFRβ cells into athymic nude mice resulted in a significant decrease in tumor incidence compared with control mice (P < 0.01). This attenuated growth correlated with decreased cancer cell proliferation, angiogenesis, and recruitment of stromal cells, and with an increase in the number of apoptotic cells. These findings suggest that sPDGFRβ is useful for the treatment of breast cancer bone metastasis."},"publication_date":"2011-08-03","publication_name":{"en":"Cancer Science","ja":"Cancer Science"},"volume":"Vol.102","number":"No.10","starting_page":"1904","ending_page":"1910","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1111/j.1349-7006.2011.02026.x"],"issn":["1349-7006"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/21737670","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=255178","label":"url"}],"paper_title":{"en":"Expression of p53, Ki-67, E-cadherin, N-cadherin and TOP2A in triple-negative breast cancer.","ja":"Expression of p53, Ki-67, E-cadherin, N-cadherin and TOP2A in triple-negative breast cancer."},"authors":{"en":[{"name":"Nakagawa Misako"},{"name":"Bando Yoshimi"},{"name":"Nagao Taeko"},{"name":"Morimoto Masami"},{"name":"Takai Chikako"},{"name":"Ohnishi Takamasa"},{"name":"Honda Junko"},{"name":"Moriya Takuya"},{"name":"Izumi Keisuke"},{"name":"Takahashi Masako"},{"name":"Sasa Mitsunori"},{"name":"Tangoku Akira"}],"ja":[{"name":"中川 美砂子"},{"name":"坂東 良美"},{"name":"長尾 妙子"},{"name":"森本 雅美"},{"name":"高井 チカコ"},{"name":"大西 隆仁"},{"name":"本田 純子"},{"name":"森谷 卓也"},{"name":"泉 啓介"},{"name":"高橋 雅子"},{"name":"笹 三徳"},{"name":"丹黒 章"}]},"description":{"en":"Elucidation of the biological features of triple negative breast cancer (TNBC) is important for deciding treatment strategies. The expression of a number of biomarkers in TNBC was analyzed to elucidate those features. The subjects were 134 TNBC patients. Immunohistochemical staining was employed to analyze for eight biomarkers: cytokeratin 5/6 (CK5/6), epidermal growth factor receptor (EGFR), p53, Ki-67 antigen (Ki-67), E-cadherin, N-cadherin, topoisomerase 2 alpha (TOP2A) and B-cell lymphoma 2 (BCL-2), which were then correlated with the nuclear grade (NG), tumor diameter, and the presence/absence of lymph node metastasis, distant recurrence and lymphatic infiltration. Significantly more high than low NG TNBC exhibited positive p53, Ki-67, E-cadherin and TOP2A. High N-cadherin and TOP2A expression was shown significantly in TNBC with lymphatic infiltration, and N-cadherin was also significantly positively expressed in node metastasis-positive cases. EGFR and CK5/6 were positively expressed in high NG TNBC, but not significantly. Analysis for expression of p53, Ki-67, E-cadherin, N-cadherin and TOP2A is meaningful for deciding treatment strategies for TNBC.","ja":"Elucidation of the biological features of triple negative breast cancer (TNBC) is important for deciding treatment strategies. The expression of a number of biomarkers in TNBC was analyzed to elucidate those features. The subjects were 134 TNBC patients. Immunohistochemical staining was employed to analyze for eight biomarkers: cytokeratin 5/6 (CK5/6), epidermal growth factor receptor (EGFR), p53, Ki-67 antigen (Ki-67), E-cadherin, N-cadherin, topoisomerase 2 alpha (TOP2A) and B-cell lymphoma 2 (BCL-2), which were then correlated with the nuclear grade (NG), tumor diameter, and the presence/absence of lymph node metastasis, distant recurrence and lymphatic infiltration. Significantly more high than low NG TNBC exhibited positive p53, Ki-67, E-cadherin and TOP2A. High N-cadherin and TOP2A expression was shown significantly in TNBC with lymphatic infiltration, and N-cadherin was also significantly positively expressed in node metastasis-positive cases. EGFR and CK5/6 were positively expressed in high NG TNBC, but not significantly. Analysis for expression of p53, Ki-67, E-cadherin, N-cadherin and TOP2A is meaningful for deciding treatment strategies for TNBC."},"publication_date":"2011-06","publication_name":{"en":"Anticancer Research","ja":"Anticancer Research"},"volume":"Vol.31","number":"No.6","starting_page":"2389","ending_page":"2393","languages":["eng"],"referee":true,"identifiers":{"issn":["1791-7530"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"http://ci.nii.ac.jp/naid/10030568662/","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/21465226","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1573668925529609856/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=258420","label":"url"}],"paper_title":{"en":"Among triple-negative breast cancers, HER2(0) breast cancer shows a strong tendency to be basal-like compared with HER2(1+) breast cancer: preliminary results.","ja":"Among triple-negative breast cancers, HER2(0) breast cancer shows a strong tendency to be basal-like compared with HER2(1+) breast cancer: preliminary results."},"authors":{"en":[{"name":"Nakagawa Misako"},{"name":"Bando Yoshimi"},{"name":"Nagao Taeko"},{"name":"Takai Chikako"},{"name":"Ohnishi Takamasa"},{"name":"Honda Junko"},{"name":"Moriya Takuya"},{"name":"Izumi Keisuke"},{"name":"Takahashi Masako"},{"name":"Tangoku Akira"},{"name":"Sasa Mitsunori"}],"ja":[{"name":"中川 美砂子"},{"name":"坂東 良美"},{"name":"長尾 妙子"},{"name":"Takai Chikako"},{"name":"Ohnishi Takamasa"},{"name":"本田 純子"},{"name":"Moriya Takuya"},{"name":"泉 啓介"},{"name":"Takahashi Masako"},{"name":"丹黒 章"},{"name":"Sasa Mitsunori"}]},"description":{"en":"Diagnosis of triple-negative breast cancer (ER-negative, PgR-negative, HER2-negative; TNBC) is performed by means of immunohistological staining. HER2-negative includes HER2(0) and HER2(1+), based on differences in the staining intensity, but there have been no reports on comparison of these two types in TNBC. Accordingly, this study was designed to investigate the possible differences in the biological characteristics of HER2(0) breast cancer and HER2(1+) breast cancer in TNBC. Tissue specimens from 89 TNBC patients were immunohistochemically stained for CK5/6, EGFR, p53, Ki67, E-cadherin, TOP2A and Bcl-2. The expressions of these markers and the clinicopathological findings were compared between the HER2(0) patient group and the HER2(1+) patient group. When either CK5/6 or EGFR was positive, the specimen was judged to be the basal-like phenotype of breast cancer. The percentages of CK5/6- and/or EGFR-positive specimens in the HER2(0) and HER2(1+) groups were 44.9 and 16.8%, respectively, showing that there was a significantly greater number of basal-like phenotype patients in the HER2(0) group (p < 0.01). The percentage of E-cadherin-positive specimens in the HER2(0) group was 66.6%, which was significantly greater than the 40.0% recorded in the HER2(1+) group (p < 0.05). The respective percentages of TOP2A-positive specimens in the HER2(0) and HER2(1+) groups were 55.0 and 30.0%, and the difference was statistically significant (p < 0.05). In TNBC, HER2(0) breast cancer showed a strong tendency to include more of the basal-like phenotype compared with HER2(1+) breast cancer. The staining results indicated the possibility that HER2(0) breast cancer and HER2(1+) breast cancer have different characteristics.","ja":"Diagnosis of triple-negative breast cancer (ER-negative, PgR-negative, HER2-negative; TNBC) is performed by means of immunohistological staining. HER2-negative includes HER2(0) and HER2(1+), based on differences in the staining intensity, but there have been no reports on comparison of these two types in TNBC. Accordingly, this study was designed to investigate the possible differences in the biological characteristics of HER2(0) breast cancer and HER2(1+) breast cancer in TNBC. Tissue specimens from 89 TNBC patients were immunohistochemically stained for CK5/6, EGFR, p53, Ki67, E-cadherin, TOP2A and Bcl-2. The expressions of these markers and the clinicopathological findings were compared between the HER2(0) patient group and the HER2(1+) patient group. When either CK5/6 or EGFR was positive, the specimen was judged to be the basal-like phenotype of breast cancer. The percentages of CK5/6- and/or EGFR-positive specimens in the HER2(0) and HER2(1+) groups were 44.9 and 16.8%, respectively, showing that there was a significantly greater number of basal-like phenotype patients in the HER2(0) group (p < 0.01). The percentage of E-cadherin-positive specimens in the HER2(0) group was 66.6%, which was significantly greater than the 40.0% recorded in the HER2(1+) group (p < 0.05). The respective percentages of TOP2A-positive specimens in the HER2(0) and HER2(1+) groups were 55.0 and 30.0%, and the difference was statistically significant (p < 0.05). In TNBC, HER2(0) breast cancer showed a strong tendency to include more of the basal-like phenotype compared with HER2(1+) breast cancer. The staining results indicated the possibility that HER2(0) breast cancer and HER2(1+) breast cancer have different characteristics."},"publication_date":"2011-04-05","publication_name":{"en":"Breast Cancer","ja":"Breast Cancer"},"volume":"Vol.19","number":"No.1","starting_page":"54","ending_page":"59","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s12282-011-0265-6"],"issn":["1880-4233"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/21646734","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=233733","label":"url"}],"paper_title":{"en":"Enhanced inflammation in epicardial fat in patients with coronary artery disease.","ja":"Enhanced inflammation in epicardial fat in patients with coronary artery disease."},"authors":{"en":[{"name":"Hirata Yoichiro"},{"name":"Kurobe Hirotsugu"},{"name":"Akaike Masashi"},{"name":"Chikugo Fumio"},{"name":"Hori Takaki"},{"name":"Bando Yoshimi"},{"name":"Nishio Chika"},{"name":"Higashida Mayuko"},{"name":"Nakaya Yutaka"},{"name":"Kitagawa Tetsuya"},{"name":"Sata Masataka"}],"ja":[{"name":"Hirata Yoichiro"},{"name":"黒部 裕嗣"},{"name":"赤池 雅史"},{"name":"Chikugo Fumio"},{"name":"堀 隆樹"},{"name":"坂東 良美"},{"name":"Nishio Chika"},{"name":"Higashida Mayuko"},{"name":"中屋 豊"},{"name":"北川 哲也"},{"name":"佐田 政隆"}]},"description":{"en":"It has been hypothesized that epicardial fat, a local visceral fat depot with close proximity to coronary arteries, may serve as a source of inflammatory cytokines and cells in coronary atherosclerotic lesions. Here, we characterized infiltration of inflammatory cells and expression of adipocytokines in epicardial adipose tissue in patients with and without coronary artery disease (CAD). Pare samples were obtained from epicardial and subcutaneous adipose tissue during elective cardiac surgery (CAD, n = 8; non-CAD, n = 9). Inflammatory cell infiltration was investigated by immunohistochemical staining using antibodies against CD3, CD4, CD8 and CD68. Expression of adipocytokines was evaluated by real-time quantitative reverse transcription-polymerase chain reaction. Infiltration of macrophages and CD8-positive T cells in the epicardial adipose tissue in the CAD group was greater than that in the non-CAD group. In contrast, there was no significant difference between the two groups in the number of inflammatory cells in subcutaneous adipose tissue. No statistical difference could be found between the CAD group and the non-CAD group in the expression levels of adiponectin and inflammatory cytokines in epicardial adipose tissue. Our findings suggest that inflammatory cell infiltration is enhanced in epicardial adipose tissue, but not in subcutaneous fat, in patients with coronary artery disease. Chronic inflammation in epicardial fat may influence the pathogenesis of coronary atherosclerosis.","ja":"It has been hypothesized that epicardial fat, a local visceral fat depot with close proximity to coronary arteries, may serve as a source of inflammatory cytokines and cells in coronary atherosclerotic lesions. Here, we characterized infiltration of inflammatory cells and expression of adipocytokines in epicardial adipose tissue in patients with and without coronary artery disease (CAD). Pare samples were obtained from epicardial and subcutaneous adipose tissue during elective cardiac surgery (CAD, n = 8; non-CAD, n = 9). Inflammatory cell infiltration was investigated by immunohistochemical staining using antibodies against CD3, CD4, CD8 and CD68. Expression of adipocytokines was evaluated by real-time quantitative reverse transcription-polymerase chain reaction. Infiltration of macrophages and CD8-positive T cells in the epicardial adipose tissue in the CAD group was greater than that in the non-CAD group. In contrast, there was no significant difference between the two groups in the number of inflammatory cells in subcutaneous adipose tissue. No statistical difference could be found between the CAD group and the non-CAD group in the expression levels of adiponectin and inflammatory cytokines in epicardial adipose tissue. Our findings suggest that inflammatory cell infiltration is enhanced in epicardial adipose tissue, but not in subcutaneous fat, in patients with coronary artery disease. Chronic inflammation in epicardial fat may influence the pathogenesis of coronary atherosclerosis."},"publication_date":"2011","publication_name":{"en":"International Heart Journal","ja":"International Heart Journal"},"volume":"Vol.52","number":"No.3","starting_page":"139","ending_page":"142","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1536/ihj.52.139"],"issn":["1349-3299"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/22870098","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=224163","label":"url"}],"paper_title":{"en":"A retrospective study on TS mRNA expression and prediction of the effects of adjuvant oral 5-fluorouracil in breast cancer","ja":"A retrospective study on TS mRNA expression and prediction of the effects of adjuvant oral 5-fluorouracil in breast cancer"},"authors":{"en":[{"name":"Fuminori Aki"},{"name":"Bando Yoshimi"},{"name":"Takahashi Tetsuyuki"},{"name":"Uehara Hisanori"},{"name":"Satoshi Numoto"},{"name":"Sueyoshi Ito"},{"name":"Mitsunori Sasa"},{"name":"Izumi Keisuke"}],"ja":[{"name":"Fuminori Aki"},{"name":"坂東 良美"},{"name":"髙橋 徹行"},{"name":"上原 久典"},{"name":"Satoshi Numoto"},{"name":"Sueyoshi Ito"},{"name":"Mitsunori Sasa"},{"name":"泉 啓介"}]},"description":{"en":"Nucleic acid-metabolizing enzymes, such as thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), thymidine phosphorylase (TP) and orotate phosphoribosyl transferase (OPRT), have attracted attention as candidates for response determinants of 5-fluorouracil (5-FU). Whether the expression levels of these enzymes can be adopted as valuable parameters for 5-FU sensitivity in breast cancer has yet to be elucidated. In the present study, intratumoral mRNA expression of TS, DPD, TP and OPRT were determined in formalin-fixed paraffin-embedded surgical specimens collected from 217 breast cancer patients, using the Danenberg Tumor Profile method, which combines microdissection and real-time-polymerase chain reaction. The significance of these enzymes as prognostic and 5-FU efficacy-predicting factors was evaluated. Our data showed that a low DPD expression is related to a high nuclear grade and other factors including hormone receptor-negativity. Low expression levels of TP were found in hormone receptor-negative tumors. TS and OPRT expression were not related to various clinicopathological factors, but patients with a high TS mRNA expression showed a significantly poorer prognosis in cases where 5-FU was not administered. The efficacy of 5-FU was more significant when administered for more than 6 months in the group with a high TS mRNA expression. These data suggest that TS mRNA expression in breast cancer tissue is an ideal predictor of outcomes for patients with no administration of 5-FU, and of the efficacy of 5-FU.","ja":"Nucleic acid-metabolizing enzymes, such as thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), thymidine phosphorylase (TP) and orotate phosphoribosyl transferase (OPRT), have attracted attention as candidates for response determinants of 5-fluorouracil (5-FU). Whether the expression levels of these enzymes can be adopted as valuable parameters for 5-FU sensitivity in breast cancer has yet to be elucidated. In the present study, intratumoral mRNA expression of TS, DPD, TP and OPRT were determined in formalin-fixed paraffin-embedded surgical specimens collected from 217 breast cancer patients, using the Danenberg Tumor Profile method, which combines microdissection and real-time-polymerase chain reaction. The significance of these enzymes as prognostic and 5-FU efficacy-predicting factors was evaluated. Our data showed that a low DPD expression is related to a high nuclear grade and other factors including hormone receptor-negativity. Low expression levels of TP were found in hormone receptor-negative tumors. TS and OPRT expression were not related to various clinicopathological factors, but patients with a high TS mRNA expression showed a significantly poorer prognosis in cases where 5-FU was not administered. The efficacy of 5-FU was more significant when administered for more than 6 months in the group with a high TS mRNA expression. These data suggest that TS mRNA expression in breast cancer tissue is an ideal predictor of outcomes for patients with no administration of 5-FU, and of the efficacy of 5-FU."},"publication_date":"2010-11","publication_name":{"en":"Oncology Letters","ja":"Oncology Letters"},"volume":"Vol.1","number":"No.6","starting_page":"981","ending_page":"988","languages":["eng"],"referee":true,"identifiers":{"doi":["10.3892/ol.2010.186"],"issn":["1792-1082"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/114377","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/20145615","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-77649272127&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=207481","label":"url"}],"paper_title":{"en":"High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer.","ja":"High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer."},"authors":{"en":[{"name":"Wang Elaine Lu"},{"name":"Qian Zhi-Rong"},{"name":"Nakasono Masahiko"},{"name":"Tanahashi Toshihito"},{"name":"Yoshimoto Katsuhiko"},{"name":"Bando Yoshimi"},{"name":"Kudo Eiji"},{"name":"Shimada Mitsuo"},{"name":"Sano Toshiaki"}],"ja":[{"name":"Wang Elaine Lu"},{"name":"銭 志栄"},{"name":"Nakasono Masahiko"},{"name":"棚橋 俊仁"},{"name":"吉本 勝彦"},{"name":"坂東 良美"},{"name":"工藤 英治"},{"name":"島田 光生"},{"name":"佐野 壽昭"}]},"description":{"en":"BACKGROUND: The Toll-like receptor (TLR) 4 signalling pathway has been shown to have oncogenic effects in vitro and in vivo. To demonstrate the role of TLR4 signalling in colon tumourigenesis, we examined the expression of TLR4 and myeloid differentiation factor 88 (MyD88) in colorectal cancer (CRC). METHODS: The expression of TLR4 and MyD88 in 108 CRC samples, 15 adenomas, and 15 normal mucosae was evaluated by immunohistochemistry, and the correlations between their immunoscores and clinicopathological variables, including disease-free survival (DFS) and overall survival (OS), were analysed. RESULTS: Compared with normal mucosae and adenomas, 20% cancers displayed high expression of TLR4, and 23% cancers showed high expression of MyD88. The high expression of TLR4 and MyD88 was significantly correlated with liver metastasis (P=0.0001, P=0.0054). In univariate analysis, the high expression of TLR4 was significantly associated with shorter OS (hazard ratio (HR): 2.17; 95% confidence interval (95% CI): 1.15-4.07; P=0.015). The high expression of MyD88 expression was significantly associated with poor DFS and OS (HR: 2.33; 95% CI: 1.31-4.13; P=0.0038 and HR: 3.03; 95% CI: 1.67-5.48; P=0.0002). The high combined expression of TLR4 and MyD88 was also significantly associated with poor DFS and OS (HR: 2.25; 95% CI: 1.27-3.99; P=0.0053 and HR: 2.97; 95% CI: 1.64-5.38; P=0.0003). Multivariate analysis showed that high expressions of TLR4 (OS: adjusted HR: 1.88; 95% CI: 0.99-3.55; P=0.0298) and MyD88 (DFS: adjusted HR: 1.93; 95% CI: 1.01-3.67; P=0.0441; OS: adjusted HR: 2.25; 95% CI: 1.17-4.33; P=0.0112) were independent prognostic factors of OS. Furthermore, high co-expression of TLR4/MyD88 was strongly associated with both poor DFS and OS. CONCLUSION: Our findings suggest that high expression of TLR4 and MyD88 is associated with liver metastasis and is an independent predictor of poor prognosis in patients with CRC.","ja":"BACKGROUND: The Toll-like receptor (TLR) 4 signalling pathway has been shown to have oncogenic effects in vitro and in vivo. To demonstrate the role of TLR4 signalling in colon tumourigenesis, we examined the expression of TLR4 and myeloid differentiation factor 88 (MyD88) in colorectal cancer (CRC). METHODS: The expression of TLR4 and MyD88 in 108 CRC samples, 15 adenomas, and 15 normal mucosae was evaluated by immunohistochemistry, and the correlations between their immunoscores and clinicopathological variables, including disease-free survival (DFS) and overall survival (OS), were analysed. RESULTS: Compared with normal mucosae and adenomas, 20% cancers displayed high expression of TLR4, and 23% cancers showed high expression of MyD88. The high expression of TLR4 and MyD88 was significantly correlated with liver metastasis (P=0.0001, P=0.0054). In univariate analysis, the high expression of TLR4 was significantly associated with shorter OS (hazard ratio (HR): 2.17; 95% confidence interval (95% CI): 1.15-4.07; P=0.015). The high expression of MyD88 expression was significantly associated with poor DFS and OS (HR: 2.33; 95% CI: 1.31-4.13; P=0.0038 and HR: 3.03; 95% CI: 1.67-5.48; P=0.0002). The high combined expression of TLR4 and MyD88 was also significantly associated with poor DFS and OS (HR: 2.25; 95% CI: 1.27-3.99; P=0.0053 and HR: 2.97; 95% CI: 1.64-5.38; P=0.0003). Multivariate analysis showed that high expressions of TLR4 (OS: adjusted HR: 1.88; 95% CI: 0.99-3.55; P=0.0298) and MyD88 (DFS: adjusted HR: 1.93; 95% CI: 1.01-3.67; P=0.0441; OS: adjusted HR: 2.25; 95% CI: 1.17-4.33; P=0.0112) were independent prognostic factors of OS. Furthermore, high co-expression of TLR4/MyD88 was strongly associated with both poor DFS and OS. CONCLUSION: Our findings suggest that high expression of TLR4 and MyD88 is associated with liver metastasis and is an independent predictor of poor prognosis in patients with CRC."},"publication_date":"2010-02-09","publication_name":{"en":"British Journal of Cancer","ja":"British Journal of Cancer"},"volume":"Vol.102","number":"No.5","starting_page":"908","ending_page":"915","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1038/sj.bjc.6605558"],"issn":["1532-1827"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/19685198","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=194661","label":"url"}],"paper_title":{"en":"Potential pathophysiological role of D-amino acid oxidase in schizophrenia: immunohistochemical and in situ hybridization study of the expression in human and rat brain","ja":"Potential pathophysiological role of D-amino acid oxidase in schizophrenia: immunohistochemical and in situ hybridization study of the expression in human and rat brain"},"authors":{"en":[{"name":"Ono Koji"},{"name":"Shishido Yuji"},{"name":"Park Ki Hwan"},{"name":"Kawazoe Tomoya"},{"name":"Iwana Sanae"},{"name":"Chung Seongpil"},{"name":"El-Magd Mohamed Abou Rabab"},{"name":"YORITA Kazuko"},{"name":"Okano Mai"},{"name":"Watanabe Takeshi"},{"name":"Sano Nobuya"},{"name":"Bando Yoshimi"},{"name":"Arima Kunimasa"},{"name":"Sakai Takashi"},{"name":"Fukui Kiyoshi"}],"ja":[{"name":"小野 公嗣"},{"name":"宍戸 裕二"},{"name":"朴 煥埼"},{"name":"川添 僚也"},{"name":"岩名 沙奈恵"},{"name":"鄭 丞弼"},{"name":"El-Magd Mohamed Abou Rabab"},{"name":"頼田 和子"},{"name":"岡野 舞"},{"name":"Watanabe Takeshi"},{"name":"佐野 暢哉"},{"name":"坂東 良美"},{"name":"有馬 邦正"},{"name":"坂井 隆志"},{"name":"福井 清"}]},"description":{"en":"D-Amino acid oxidase (DAO) is a peroxisomal flavoenzyme that catalyzes oxidative deamination of a wide range of D-amino acids. Among the possible substrates of DAO in vivo, D-serine is proposed to be a neuromodulator of the N-methyl-D-aspartate (NMDA) type glutamate receptor. The gene for DAO was reported to be associated with schizophrenia. Since DAO is expected to be one of the key enzymes in the regulation of NMDA neurotransmission, the modulation of the enzyme activity is expected to be therapeutical for neuronal disorders. In search of the pathophysiological role of DAO, we analyzed the distribution of DAO mRNA and protein in the rat and human brain. In rat, the distribution of DAO mRNA was newly detected in choroid plexus (CP) epithelial cells in addition to glial cells of pons, medulla oblongata, and especially Bergmann glia of cerebellum. Moreover, to investigate how DAO expression level is altered in schizophrenia, we performed immunohistochemistry in the human brain. In agreement with the results in the rat brain, the immunoreactivity for DAO was detected in glial cells of rhombencephalon and in CP. Furthermore, higher level of DAO expression was observed in schizophrenic CP epithelial cells than that in non-schizophrenic cases. These results suggest that an increase in DAO expression in parts of the brain is involved in aberrant D-amino acid metabolism. In particular, gene expression of DAO in CP suggests that DAO may regulate D-amino acid concentration by modulating the cerebrospinal fluid and may be regarded as a potential therapeutic target for schizophrenia.","ja":"D-Amino acid oxidase (DAO) is a peroxisomal flavoenzyme that catalyzes oxidative deamination of a wide range of D-amino acids. Among the possible substrates of DAO in vivo, D-serine is proposed to be a neuromodulator of the N-methyl-D-aspartate (NMDA) type glutamate receptor. The gene for DAO was reported to be associated with schizophrenia. Since DAO is expected to be one of the key enzymes in the regulation of NMDA neurotransmission, the modulation of the enzyme activity is expected to be therapeutical for neuronal disorders. In search of the pathophysiological role of DAO, we analyzed the distribution of DAO mRNA and protein in the rat and human brain. In rat, the distribution of DAO mRNA was newly detected in choroid plexus (CP) epithelial cells in addition to glial cells of pons, medulla oblongata, and especially Bergmann glia of cerebellum. Moreover, to investigate how DAO expression level is altered in schizophrenia, we performed immunohistochemistry in the human brain. In agreement with the results in the rat brain, the immunoreactivity for DAO was detected in glial cells of rhombencephalon and in CP. Furthermore, higher level of DAO expression was observed in schizophrenic CP epithelial cells than that in non-schizophrenic cases. These results suggest that an increase in DAO expression in parts of the brain is involved in aberrant D-amino acid metabolism. In particular, gene expression of DAO in CP suggests that DAO may regulate D-amino acid concentration by modulating the cerebrospinal fluid and may be regarded as a potential therapeutic target for schizophrenia."},"publication_date":"2009-09-15","publication_name":{"en":"Journal of Neural Transmission","ja":"Journal of Neural Transmission"},"volume":"Vol.116","number":"No.10","starting_page":"1335","ending_page":"1347","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s00702-009-0289-7"],"issn":["1435-1463"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/111314","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/19763020","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=224162","label":"url"}],"paper_title":{"en":"Low susceptibility to N-ethyl-N-nitrosourea-induced transplacental carcinogenesis in Long-Evans Cinnamon (LEC) rats","ja":"Low susceptibility to N-ethyl-N-nitrosourea-induced transplacental carcinogenesis in Long-Evans Cinnamon (LEC) rats"},"authors":{"en":[{"name":"Takeshi Tsuchigauchi"},{"name":"Takahashi Tetsuyuki"},{"name":"Takamasa Ohnishi"},{"name":"Ogawa Hirohisa"},{"name":"Bando Yoshimi"},{"name":"Uehara Hisanori"},{"name":"Tamatsu Takizawa"},{"name":"Shinya Kaneda"},{"name":"Tokiko Nakai"},{"name":"Shiota Hiroshi"},{"name":"Izumi Keisuke"}],"ja":[{"name":"Takeshi Tsuchigauchi"},{"name":"髙橋 徹行"},{"name":"Takamasa Ohnishi"},{"name":"小川 博久"},{"name":"坂東 良美"},{"name":"上原 久典"},{"name":"Tamatsu Takizawa"},{"name":"Shinya Kaneda"},{"name":"Tokiko Nakai"},{"name":"塩田 洋"},{"name":"泉 啓介"}]},"description":{"en":"The Long-Evans Cinnamon (LEC) rat, an animal model of Wilson's disease, is resistant to a variety of chemical carcinogenesis except liver and colon. In the present study, N-ethyl-N-nitrosourea (ENU)-induced transplacental carcinogenesis was examined in male and female LEC, Long-Evans Agouti (LEA), a sibling line of the LEC rat, and F344 rats (n=21). ENU was administered to pregnant rats as a single s.c. injection at a dose of 60 mg/kg body weight on the 17th day after conception. Cerebral/spinal gliomas and trigeminal/spinal nerve schwannomas developed in both LEA and F344 rats at 30 weeks of age, but no nervous system tumors developed in LEC rats, the difference being statistically significant. Lung adenomas also developed in LEA and F344 rats, but not in LEC rats. Semiquantitative RT-PCR demonstrated that metallothionein (MT)1a, MT2 and O(6)-methylguanine-DNA methyltransferase (MGMT) mRNA levels in the liver of LEC rats were higher than those in F344 and LEA rats. In addition, Western blot analysis showed that MT (MT1 plus MT2) in the liver of LEC rats was also higher than that in other strains. Present results suggest that high levels of MT and/or MGMT contribute to the resistance to nitrosamine-induced carcinogenesis in LEC rats.","ja":"The Long-Evans Cinnamon (LEC) rat, an animal model of Wilson's disease, is resistant to a variety of chemical carcinogenesis except liver and colon. In the present study, N-ethyl-N-nitrosourea (ENU)-induced transplacental carcinogenesis was examined in male and female LEC, Long-Evans Agouti (LEA), a sibling line of the LEC rat, and F344 rats (n=21). ENU was administered to pregnant rats as a single s.c. injection at a dose of 60 mg/kg body weight on the 17th day after conception. Cerebral/spinal gliomas and trigeminal/spinal nerve schwannomas developed in both LEA and F344 rats at 30 weeks of age, but no nervous system tumors developed in LEC rats, the difference being statistically significant. Lung adenomas also developed in LEA and F344 rats, but not in LEC rats. Semiquantitative RT-PCR demonstrated that metallothionein (MT)1a, MT2 and O(6)-methylguanine-DNA methyltransferase (MGMT) mRNA levels in the liver of LEC rats were higher than those in F344 and LEA rats. In addition, Western blot analysis showed that MT (MT1 plus MT2) in the liver of LEC rats was also higher than that in other strains. Present results suggest that high levels of MT and/or MGMT contribute to the resistance to nitrosamine-induced carcinogenesis in LEC rats."},"publication_date":"2009-08","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.56","number":"No.3-4","starting_page":"93","ending_page":"98","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.56.93"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/19462449","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=192637","label":"url"}],"paper_title":{"en":"Triterpenes augment the inhibitory effects of anticancer drugs on growth of human esophageal carcinoma cells in vitro and suppress experimental metastasis in vivo.","ja":"Triterpenes augment the inhibitory effects of anticancer drugs on growth of human esophageal carcinoma cells in vitro and suppress experimental metastasis in vivo."},"authors":{"en":[{"name":"Yamai Hiromichi"},{"name":"Sawada Naruhiko"},{"name":"Yoshida Takahiro"},{"name":"Seike Junnichi"},{"name":"Takizawa Hiromitsu"},{"name":"Kenzaki Koichiro"},{"name":"Miyoshi Takanori"},{"name":"Kondo Kazuya"},{"name":"Bando Yoshimi"},{"name":"Ohnishi Yoshinari"},{"name":"Tangoku Akira"}],"ja":[{"name":"Yamai Hiromichi"},{"name":"Sawada Naruhiko"},{"name":"Yoshida Takahiro"},{"name":"Seike Junnichi"},{"name":"滝沢 宏光"},{"name":"監﨑 孝一郎"},{"name":"Miyoshi Takanori"},{"name":"近藤 和也"},{"name":"坂東 良美"},{"name":"Ohnishi Yoshinari"},{"name":"丹黒 章"}]},"description":{"en":"The antineoplastic effects of combinations of anticancer drugs (5-fluorouracil, irinotecan and cisplatin) and triterpenes (ursolic acid, betulinic acid, oleanolic acid and a Japanese apricot extract (JAE) containing triterpenes) on esophageal squamous carcinoma cells were examined by the WST-8 (2-(2-methoxy- 4-nitrophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium, monosodium salt) assay in vitro and by an animal model in vivo. Triterpenes and JAE showed additive and synergistic cytotoxic effects, respectively, on esophageal squamous carcinoma cells (YES-2cells) by combinational use of 5-fluorouracil. JAE and 5-fluorouracil induced cell cycle arrest at G2/M phase and at S phase, respectively, and caused apoptosis in YES-2 cells. A new animal model of esophageal cancer causing tumor colonization of the peritoneal cavity and producing bloody ascites was made by injecting YES-2 cells into the peritoneal cavity of a severe combined immunodeficiency mouse. In this model, 5-fluorouracil inhibited colonization of tumor cells in the peritoneum. The addition of JAE to 5-fluorouracil augmented the suppression of experimental metastasis of the peritoneum. The numbers of peritoneal nodules of more than 2 mm in diameter in mice treated with 5-fluorouracil and JAE were less than those in mice treated with 5-fluorouracil alone or JAE alone. These results suggest that triterpenes, especially JAE, are effective supplements for enhancing the chemotherapeutic effect of 5-fluorouracil on esophageal cancer. (c) 2009 UICC.","ja":"The antineoplastic effects of combinations of anticancer drugs (5-fluorouracil, irinotecan and cisplatin) and triterpenes (ursolic acid, betulinic acid, oleanolic acid and a Japanese apricot extract (JAE) containing triterpenes) on esophageal squamous carcinoma cells were examined by the WST-8 (2-(2-methoxy- 4-nitrophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium, monosodium salt) assay in vitro and by an animal model in vivo. Triterpenes and JAE showed additive and synergistic cytotoxic effects, respectively, on esophageal squamous carcinoma cells (YES-2cells) by combinational use of 5-fluorouracil. JAE and 5-fluorouracil induced cell cycle arrest at G2/M phase and at S phase, respectively, and caused apoptosis in YES-2 cells. A new animal model of esophageal cancer causing tumor colonization of the peritoneal cavity and producing bloody ascites was made by injecting YES-2 cells into the peritoneal cavity of a severe combined immunodeficiency mouse. In this model, 5-fluorouracil inhibited colonization of tumor cells in the peritoneum. The addition of JAE to 5-fluorouracil augmented the suppression of experimental metastasis of the peritoneum. The numbers of peritoneal nodules of more than 2 mm in diameter in mice treated with 5-fluorouracil and JAE were less than those in mice treated with 5-fluorouracil alone or JAE alone. These results suggest that triterpenes, especially JAE, are effective supplements for enhancing the chemotherapeutic effect of 5-fluorouracil on esophageal cancer. (c) 2009 UICC."},"publication_date":"2009-03-19","publication_name":{"en":"International Journal of Cancer","ja":"International Journal of Cancer"},"volume":"Vol.125","number":"No.4","starting_page":"952","ending_page":"960","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1002/ijc.24433"],"issn":["1097-0215"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/19280950","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=192662","label":"url"}],"paper_title":{"en":"Surgically treated pleomorphic carcinoma of the lung","ja":"肺多形癌の3切除例"},"authors":{"en":[{"name":"Toba Hiroaki"},{"name":"Sakiyama Shoji"},{"name":"Morimoto M"},{"name":"Takizawa Hiromitsu"},{"name":"Kenzaki Koichiro"},{"name":"Kondo Kazuya"},{"name":"Bando Yoshimi"},{"name":"Tangoku Akira"}],"ja":[{"name":"鳥羽 博明"},{"name":"先山 正二"},{"name":"森本 雅美"},{"name":"滝沢 宏光"},{"name":"監﨑 孝一郎"},{"name":"近藤 和也"},{"name":"坂東 良美"},{"name":"丹黒 章"}]},"description":{"en":"We experienced 3 resected cases of pleomorphic carcinoma of the lung. Each cases were 74-year-old man (case 1), 74-year-old woman (case 2) and 69-year-old man (case 3). Two patients (case 1 and 2) were histologically diagnosed as pleomorphic carcinoma composed of spindle cell carcinoma with giant cell carcinoma. One patient (case 3) was similarly diagnosed as pleomorphic carcinoma composed of spindle cell carcinoma with adenocarcinoma and squamous cell carcinoma. Although lymph nodes metastasis were not recognized in all patients, invasion to vessels were recognized in 2 patients (case 1 and 3). In one patient (case 1), recurrence was recognized at contralateral side 1 month after surgery and he died of other disease 2 months after surgery. The other 2 patients were alive without recurrence 24 and 5 months after surgery. Recently it is reported that recurrence is recognized at early phase after surgery and prognosis is poor in a case with vessel invasions in spite of pathological NO state. Since one patient (case 3) had nonmetastatic lymph nodes with vessel invasions, careful observation is considered to be necessary.","ja":"We experienced 3 resected cases of pleomorphic carcinoma of the lung. Each cases were 74-year-old man (case 1), 74-year-old woman (case 2) and 69-year-old man (case 3). Two patients (case 1 and 2) were histologically diagnosed as pleomorphic carcinoma composed of spindle cell carcinoma with giant cell carcinoma. One patient (case 3) was similarly diagnosed as pleomorphic carcinoma composed of spindle cell carcinoma with adenocarcinoma and squamous cell carcinoma. Although lymph nodes metastasis were not recognized in all patients, invasion to vessels were recognized in 2 patients (case 1 and 3). In one patient (case 1), recurrence was recognized at contralateral side 1 month after surgery and he died of other disease 2 months after surgery. The other 2 patients were alive without recurrence 24 and 5 months after surgery. Recently it is reported that recurrence is recognized at early phase after surgery and prognosis is poor in a case with vessel invasions in spite of pathological NO state. Since one patient (case 3) had nonmetastatic lymph nodes with vessel invasions, careful observation is considered to be necessary."},"publication_date":"2009-03","publication_name":{"en":"The Japanese Journal of Thoracic Surgery","ja":"胸部外科"},"volume":"Vol.62","number":"No.3","starting_page":"202","ending_page":"206","languages":["jpn"],"referee":true,"identifiers":{"issn":["0021-5252"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/19411035","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=190230","label":"url"}],"paper_title":{"en":"Adenosarcoma of the uterus: magnetic resonance imaging characteristics.","ja":"Adenosarcoma of the uterus: magnetic resonance imaging characteristics."},"authors":{"en":[{"name":"Takeuchi Mayumi"},{"name":"Matsuzaki Kenji"},{"name":"Nishitani Hiromu"},{"name":"Kudo Eiji"},{"name":"Bando Yoshimi"}],"ja":[{"name":"竹内 麻由美"},{"name":"松崎 健司"},{"name":"西谷 弘"},{"name":"工藤 英治"},{"name":"坂東 良美"}]},"description":{"en":"Adenosarcoma of the uterus is a rare tumor containing benign glandular epithelial and malignant mesenchymal elements. Typical adenosarcoma is a low-grade tumor, presents as a large polypoid mass occupying the endometrial cavity, and may protrude into the vaginal cavity. The presence of small hyperintense cysts scattered within the mass on T(2)-weighted imaging, reflecting glandular epithelial components, and relatively low signal intensity on high b-value diffusion-weighted imaging, reflecting its low-grade nature, may be characteristic findings.","ja":"Adenosarcoma of the uterus is a rare tumor containing benign glandular epithelial and malignant mesenchymal elements. Typical adenosarcoma is a low-grade tumor, presents as a large polypoid mass occupying the endometrial cavity, and may protrude into the vaginal cavity. The presence of small hyperintense cysts scattered within the mass on T(2)-weighted imaging, reflecting glandular epithelial components, and relatively low signal intensity on high b-value diffusion-weighted imaging, reflecting its low-grade nature, may be characteristic findings."},"publication_date":"2009","publication_name":{"en":"Clinical Imaging","ja":"Clinical Imaging"},"volume":"Vol.33","number":"No.3","starting_page":"244","ending_page":"247","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.clinimag.2008.11.003"],"issn":["1873-4499"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/18559079","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-46649096056&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=192653","label":"url"}],"paper_title":{"en":"A case of matrix-producing carcinoma of the breast.","ja":"A case of matrix-producing carcinoma of the breast."},"authors":{"en":[{"name":"Hirose Toshiyuki"},{"name":"Honda Junko"},{"name":"Bando Yoshimi"},{"name":"Sasa Mitsunori"},{"name":"Hirose Yukiko"},{"name":"Nagao Taeko"},{"name":"Tangoku Akira"}],"ja":[{"name":"Hirose Toshiyuki"},{"name":"Honda Junko"},{"name":"坂東 良美"},{"name":"Sasa Mitsunori"},{"name":"Hirose Yukiko"},{"name":"長尾 妙子"},{"name":"丹黒 章"}]},"description":{"en":"BACKGROUND: Matrix-producing carcinoma (MPC) of the breast is one variant type of metaplastic carcinoma. The cellular origin of MPC remains unclear. It has been suggested the tumor cells in MPC have the combined characteristics of both epithelial cells and mesenchymal cells. Several reports suggested that the tumor cells in MPC might originate from the myoepithelial cells, but others suggested the origin was basal-like cells. CASE PRESENTATION: The patient was a 42-year-old Japanese female. A tumor of about 2 cm in diameter was noted in the right breast. CT revealed the circumference of the tumor to have a ring-like structure, and fine needle aspiration cytology indicated suspicion for malignancy. Breast-conserving surgery was performed. Histopathological studies showed carcinoma cells, having cuboidal to oval-shaped nucleus, were proliferating in cord-like and sheet-like structures in the periphery. In the central areas of the tumor, myxoedematous area was observed with cartilaginous matrix and necrosis. The diagnosis was a matrix-producing carcinoma. Immunohistochemical findings showed the tumor cells had the characteristics of both epithelial cells and mesenchymal cells, while being negative for estrogen receptor, progesterone receptor, Her2, myoepithelial cell markers and basal cell markers. CONCLUSION: The findings for our present patient and many of the other MPC patients reported in the published literature indicate that this breast cancer has the properties of both epithelial cells and mesenchymal cells. In addition, there is a possibility that matrix-producing tumor cells of our present patient may have a feature of undifferentiated cells.","ja":"BACKGROUND: Matrix-producing carcinoma (MPC) of the breast is one variant type of metaplastic carcinoma. The cellular origin of MPC remains unclear. It has been suggested the tumor cells in MPC have the combined characteristics of both epithelial cells and mesenchymal cells. Several reports suggested that the tumor cells in MPC might originate from the myoepithelial cells, but others suggested the origin was basal-like cells. CASE PRESENTATION: The patient was a 42-year-old Japanese female. A tumor of about 2 cm in diameter was noted in the right breast. CT revealed the circumference of the tumor to have a ring-like structure, and fine needle aspiration cytology indicated suspicion for malignancy. Breast-conserving surgery was performed. Histopathological studies showed carcinoma cells, having cuboidal to oval-shaped nucleus, were proliferating in cord-like and sheet-like structures in the periphery. In the central areas of the tumor, myxoedematous area was observed with cartilaginous matrix and necrosis. The diagnosis was a matrix-producing carcinoma. Immunohistochemical findings showed the tumor cells had the characteristics of both epithelial cells and mesenchymal cells, while being negative for estrogen receptor, progesterone receptor, Her2, myoepithelial cell markers and basal cell markers. CONCLUSION: The findings for our present patient and many of the other MPC patients reported in the published literature indicate that this breast cancer has the properties of both epithelial cells and mesenchymal cells. In addition, there is a possibility that matrix-producing tumor cells of our present patient may have a feature of undifferentiated cells."},"publication_date":"2008-06-17","publication_name":{"en":"World Journal of Surgical Oncology","ja":"World Journal of Surgical Oncology"},"volume":"Vol.6","starting_page":"60","ending_page":"60","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1186/1477-7819-6-60"],"issn":["1477-7819"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/18790761","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=224161","label":"url"}],"paper_title":{"en":"Soluble EP2 neutralizes prostaglandin E2-induced cell signaling and inhibits osteolytic tumor growth","ja":"Soluble EP2 neutralizes prostaglandin E2-induced cell signaling and inhibits osteolytic tumor growth"},"authors":{"en":[{"name":"Takahashi Tetsuyuki"},{"name":"Uehara Hisanori"},{"name":"Bando Yoshimi"},{"name":"Izumi Keisuke"}],"ja":[{"name":"髙橋 徹行"},{"name":"上原 久典"},{"name":"坂東 良美"},{"name":"泉 啓介"}]},"description":{"en":"Prostaglandin E2 (PGE2) plays a key role in osteolytic bone metastasis as well as roles in inflammation, cell growth, and tumor development. PGE2 exerts its effects by binding and activating E-prostanoid receptor (EP). In this study, we propose a new approach for blocking EP-mediated cell signaling using a soluble chimeric EP2 fragment. Mammalian expression vectors encoding several human EP2 cDNAs were introduced into 293 cells and the culture medium was tested for their function as a decoy receptor for PGE2. PGE2 binding assays revealed that culture medium containing the second extracellular region of EP2 (FuEP2/Ex2) had binding activity. FuEP2/Ex2 neutralized PGE2-induced cyclic AMP production, cyclic AMP-responsive element binding protein phosphorylation, and subsequent induction of cyclooxygenase-2, interleukin (IL)-1beta, and IL-6 mRNAs. In human osteoblasts, this culture medium neutralized the induction of receptor activator of nuclear factor-kappaB ligand mRNA. A stable transfectant expressing FuEP2/Ex2 was established from human prostate cancer PC-3 cells (PC3-FuEP2/Ex2). PC3-FuEP2/Ex2 cells grew at similar rates to vector control cells under normal culture conditions, although PGE2-induced growth stimulation was suppressed. Intraosseous injection of PC3-FuEP2/Ex2 cells into the tibia of athymic nude mice revealed that the degrees of tumor growth and osteolysis were decreased compared with control cell-injected mice, with decreased osteoclasts and increased apoptotic cells. Furthermore, the cyclooxygenase-2, IL-1beta, and IL-6 mRNA levels were reduced in the tumor lesions. These data suggest that FuEP2/Ex2 is useful for treating osteolytic bone metastasis and cancers that depend on EP signaling for their growth and development.","ja":"Prostaglandin E2 (PGE2) plays a key role in osteolytic bone metastasis as well as roles in inflammation, cell growth, and tumor development. PGE2 exerts its effects by binding and activating E-prostanoid receptor (EP). In this study, we propose a new approach for blocking EP-mediated cell signaling using a soluble chimeric EP2 fragment. Mammalian expression vectors encoding several human EP2 cDNAs were introduced into 293 cells and the culture medium was tested for their function as a decoy receptor for PGE2. PGE2 binding assays revealed that culture medium containing the second extracellular region of EP2 (FuEP2/Ex2) had binding activity. FuEP2/Ex2 neutralized PGE2-induced cyclic AMP production, cyclic AMP-responsive element binding protein phosphorylation, and subsequent induction of cyclooxygenase-2, interleukin (IL)-1beta, and IL-6 mRNAs. In human osteoblasts, this culture medium neutralized the induction of receptor activator of nuclear factor-kappaB ligand mRNA. A stable transfectant expressing FuEP2/Ex2 was established from human prostate cancer PC-3 cells (PC3-FuEP2/Ex2). PC3-FuEP2/Ex2 cells grew at similar rates to vector control cells under normal culture conditions, although PGE2-induced growth stimulation was suppressed. Intraosseous injection of PC3-FuEP2/Ex2 cells into the tibia of athymic nude mice revealed that the degrees of tumor growth and osteolysis were decreased compared with control cell-injected mice, with decreased osteoclasts and increased apoptotic cells. Furthermore, the cyclooxygenase-2, IL-1beta, and IL-6 mRNA levels were reduced in the tumor lesions. These data suggest that FuEP2/Ex2 is useful for treating osteolytic bone metastasis and cancers that depend on EP signaling for their growth and development."},"publication_date":"2008-06-09","publication_name":{"en":"Molecular Cancer Therapeutics","ja":"Molecular Cancer Therapeutics"},"volume":"Vol.7","number":"No.9","starting_page":"2807","ending_page":"2816","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1158/1535-7163.MCT-08-0153"],"issn":["1535-7163"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/17957470","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=191660","label":"url"}],"paper_title":{"en":"Inhibitory effects of fermented brown rice on induction of acute colitis by dextran sulfate sodium in rats.","ja":"Inhibitory effects of fermented brown rice on induction of acute colitis by dextran sulfate sodium in rats."},"authors":{"en":[{"name":"Kataoka Keiko"},{"name":"Ogasa Sachiko"},{"name":"Kuwahara Tomomi"},{"name":"Bando Yoshimi"},{"name":"Hagiwara Mari"},{"name":"Arimochi Hideki"},{"name":"Nakanishi Shuusuke"},{"name":"Iwasaki Teruaki"},{"name":"Ohnishi Yoshinari"}],"ja":[{"name":"片岡 佳子"},{"name":"Ogasa Sachiko"},{"name":"桑原 知巳"},{"name":"坂東 良美"},{"name":"Hagiwara Mari"},{"name":"有持 秀喜"},{"name":"Nakanishi Shuusuke"},{"name":"Iwasaki Teruaki"},{"name":"大西 克成"}]},"description":{"en":"Although the pathogenic mechanisms of inflammatory bowel diseases are not fully understood, colonic microbiota may affect the induction of colonic inflammation, and some probiotics and prebiotics have been reported to suppress colitis. The inhibitory effects of brown rice fermented by Aspergillus oryzae (FBRA), a fiber-rich food, on the induction of acute colitis by dextran sulfate sodium (DSS) were examined. Feeding a 5% and 10% FBRA-containing diet significantly decreased the ulcer and erosion area in the rat colon stained with Alcian blue. In another experiment, 10% FBRA feeding decreased the ulcer index (percentage of the total length of ulcers in the full length of the colon) and colitis score, which were determined by macroscopic observation. It also decreased myeloperoxidase activity in the colonic mucosa. Viable cell numbers of Lactobacillus in the feces decreased after DSS administration and was reversely correlated with severity of colitis, while the cell number of Enterobacteriaceae increased after DSS treatment and was positively correlated with colitis severity. These results indicate that FBRA has a suppressive effect on the induction of colitis by DSS and suggest FBRA-mediated modification of colonic microbiota.","ja":"Although the pathogenic mechanisms of inflammatory bowel diseases are not fully understood, colonic microbiota may affect the induction of colonic inflammation, and some probiotics and prebiotics have been reported to suppress colitis. The inhibitory effects of brown rice fermented by Aspergillus oryzae (FBRA), a fiber-rich food, on the induction of acute colitis by dextran sulfate sodium (DSS) were examined. Feeding a 5% and 10% FBRA-containing diet significantly decreased the ulcer and erosion area in the rat colon stained with Alcian blue. In another experiment, 10% FBRA feeding decreased the ulcer index (percentage of the total length of ulcers in the full length of the colon) and colitis score, which were determined by macroscopic observation. It also decreased myeloperoxidase activity in the colonic mucosa. Viable cell numbers of Lactobacillus in the feces decreased after DSS administration and was reversely correlated with severity of colitis, while the cell number of Enterobacteriaceae increased after DSS treatment and was positively correlated with colitis severity. These results indicate that FBRA has a suppressive effect on the induction of colitis by DSS and suggest FBRA-mediated modification of colonic microbiota."},"publication_date":"2008-06","publication_name":{"en":"Digestive Diseases and Sciences","ja":"Digestive Diseases and Sciences"},"volume":"Vol.53","number":"No.6","starting_page":"1601","ending_page":"1608","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s10620-007-0063-3"],"issn":["0163-2116"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/110839","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/18319546","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=192649","label":"url"}],"paper_title":{"en":"Thymidine phosphorylase and dihydropyrimidine dehydrogenase are predictive factors of therapeutic efficacy of capecitabine monotherapy for breast cancer-preliminary results.","ja":"Thymidine phosphorylase and dihydropyrimidine dehydrogenase are predictive factors of therapeutic efficacy of capecitabine monotherapy for breast cancer-preliminary results."},"authors":{"en":[{"name":"Honda Junko"},{"name":"Sasa Mitsunori"},{"name":"Moriya Takuya"},{"name":"Bando Yoshimi"},{"name":"Hirose Toshiyuki"},{"name":"Takahashi Masako"},{"name":"Nagao Taeko"},{"name":"Tangoku Akira"}],"ja":[{"name":"Honda Junko"},{"name":"Sasa Mitsunori"},{"name":"Moriya Takuya"},{"name":"坂東 良美"},{"name":"Hirose Toshiyuki"},{"name":"Takahashi Masako"},{"name":"長尾 妙子"},{"name":"丹黒 章"}]},"description":{"en":"Capecitabine monotherapy was administered for 25 patients with advanced or recurrent breast cancer, and the clinical therapeutic efficacy and its relationship to expression of 5-fluorouracil-related enzymes (i. e., thymidine phosphorylase (TP), thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD)) were investigated. The expressions of TP, TS and DPD were determined by immunohistochemical staining techniques and rated using a scoring system of 1~4. The expression score for TP/DPD showed a statistically significant correlation with the clinical response, whereas the expression score for TP/TS also showed a correlation but it was not statistically significant. The number of patients was small, but the results revealed the potential of application of the TP/DPD expression score as a factor for predicting the efficacy of the drug in individual patients.","ja":"Capecitabine monotherapy was administered for 25 patients with advanced or recurrent breast cancer, and the clinical therapeutic efficacy and its relationship to expression of 5-fluorouracil-related enzymes (i. e., thymidine phosphorylase (TP), thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD)) were investigated. The expressions of TP, TS and DPD were determined by immunohistochemical staining techniques and rated using a scoring system of 1~4. The expression score for TP/DPD showed a statistically significant correlation with the clinical response, whereas the expression score for TP/TS also showed a correlation but it was not statistically significant. The number of patients was small, but the results revealed the potential of application of the TP/DPD expression score as a factor for predicting the efficacy of the drug in individual patients."},"publication_date":"2008-02","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.55","number":"No.1-2","starting_page":"54","ending_page":"60","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.55.54"],"issn":["1343-1420"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/17710484","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=166319","label":"url"}],"paper_title":{"en":"Epistasis between hyperglycemic QTLs revealed in a double congenic of the OLETF rat","ja":"Epistasis between hyperglycemic QTLs revealed in a double congenic of the OLETF rat"},"authors":{"en":[{"name":"Kose Hiroyuki"},{"name":"Bando Yoshimi"},{"name":"Izumi Keisuke"},{"name":"Yamada Takahisa"},{"name":"Matsumoto Kozo"}],"ja":[{"name":"小瀬 博之"},{"name":"坂東 良美"},{"name":"泉 啓介"},{"name":"Yamada Takahisa"},{"name":"松本 耕三"}]},"description":{"en":"Glucose homeostasis is believed to be regulated by multiple genetic components, in addition to numerous external factors. It is therefore crucial to dissect and understand what roles each causative gene plays in maintaining proper glucose metabolism. In OLETF (Otsuka Long-Evans Tokushima Fatty) rat, a model of polygenic type 2 diabetes, at least 14 quantitative trait loci (QTLs) influencing plasma glucose levels were identified. In congenic strains some of the OLETF allelic variants were shown to increase glucose levels. In this study the focus was on two of the hyperglycemic loci, Nidd1/of and Nidd2/of. Congenic rats possessing OLETF genome fragment at either locus showed similar levels of mild hyperglycemia. A newly established double congenic rat showed a further aggravation of hyperglycemia. The Nidd1/of locus was also shown to function in the reduction of plasma leptin levels and fat weights, while the Nidd2/of locus led to increased plasma insulin and fat weights. Interestingly, both plasma leptin and fat weights reverted to the control levels in the double congenic rat. These results indicate that there is an epistatic interaction between the two loci. However, it is unlikely that the abnormal level of enhanced glucose homeostasis is mediated, at least not directly, by leptin or fat mass.","ja":"Glucose homeostasis is believed to be regulated by multiple genetic components, in addition to numerous external factors. It is therefore crucial to dissect and understand what roles each causative gene plays in maintaining proper glucose metabolism. In OLETF (Otsuka Long-Evans Tokushima Fatty) rat, a model of polygenic type 2 diabetes, at least 14 quantitative trait loci (QTLs) influencing plasma glucose levels were identified. In congenic strains some of the OLETF allelic variants were shown to increase glucose levels. In this study the focus was on two of the hyperglycemic loci, Nidd1/of and Nidd2/of. Congenic rats possessing OLETF genome fragment at either locus showed similar levels of mild hyperglycemia. A newly established double congenic rat showed a further aggravation of hyperglycemia. The Nidd1/of locus was also shown to function in the reduction of plasma leptin levels and fat weights, while the Nidd2/of locus led to increased plasma insulin and fat weights. Interestingly, both plasma leptin and fat weights reverted to the control levels in the double congenic rat. These results indicate that there is an epistatic interaction between the two loci. However, it is unlikely that the abnormal level of enhanced glucose homeostasis is mediated, at least not directly, by leptin or fat mass."},"publication_date":"2007-08-21","publication_name":{"en":"Mammalian Genome","ja":"Mammalian Genome"},"volume":"Vol.18","number":"No.8","starting_page":"609","ending_page":"615","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s00335-007-9031-7"],"issn":["0938-8990"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=164416","label":"url"}],"paper_title":{"en":"腫瘍性骨軟化症の一例","ja":"腫瘍性骨軟化症の一例"},"authors":{"en":[{"name":"近藤 剛史"},{"name":"Endo Itsuro"},{"name":"木内 美瑞穂"},{"name":"Fujinaka Yuichi"},{"name":"Inoue Daisuke"},{"name":"福本 誠二"},{"name":"大歯 浩一"},{"name":"Endo Kenji"},{"name":"Yasui Natsuo"},{"name":"長谷川 匡"},{"name":"Uehara Hisanori"},{"name":"Bando Yoshimi"},{"name":"Matsumoto Toshio"}],"ja":[{"name":"近藤 剛史"},{"name":"遠藤 逸朗"},{"name":"木内 美瑞穂"},{"name":"藤中 雄一"},{"name":"井上 大輔"},{"name":"福本 誠二"},{"name":"大歯 浩一"},{"name":"遠藤 健次"},{"name":"安井 夏生"},{"name":"長谷川 匡"},{"name":"上原 久典"},{"name":"坂東 良美"},{"name":"松本 俊夫"}]},"publication_date":"2007","publication_name":{"en":"日本内分泌学会雑誌","ja":"日本内分泌学会雑誌"},"volume":"Vol.83","starting_page":"136","ending_page":"138","languages":["jpn"],"referee":true,"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/17201157","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-33845916979&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=161626","label":"url"}],"paper_title":{"en":"False-positive in fine-needle aspiration cytology of breast disease can be reduced with p63 immunostaining- A preliminary report","ja":"False-positive in fine-needle aspiration cytology of breast disease can be reduced with p63 immunostaining- A preliminary report"},"authors":{"en":[{"name":"Nagao Taeko"},{"name":"Bando Yoshimi"},{"name":"Sasa Mitsunori"},{"name":"Morimoto Tadaoki"},{"name":"Sano Nobuya"},{"name":"Hirose Toshiyuki"},{"name":"Tangoku Akira"}],"ja":[{"name":"長尾 妙子"},{"name":"坂東 良美"},{"name":"Sasa Mitsunori"},{"name":"森本 忠興"},{"name":"Sano Nobuya"},{"name":"Hirose Toshiyuki"},{"name":"丹黒 章"}]},"description":{"en":"Myoepithelial cells of the mammary gland are considered to be a key to distinguishing benign from malignant disease in fine-needle aspiration (FNA) cytology. However, identification of these cells with Papanicolaou staining is not easy. The identification of myoepithelial cells was investigated using p63 antibodies to carry out immunostaining of FNA specimens that had been used at the time of Papanicolaou staining for 37 patients who yielded false-positives in FNA. Positively-stained cells were observed in overlying cell clusters or the background in 67.6% of the patients. There is a possibility that over-diagnosis could have been avoided by performing p63 staining for these patients. The controls consisted of stamp samples of fresh specimens obtained from 23 patients at the time of surgery for invasive carcinoma and the results of p63 immunostaining did not reveal any positive staining of tumor cells. Accordingly, these results indicate that there is a strong likelihood that there is no invasive carcinoma when many p63-positive cells are observed in the tumor cell population or the background and that p63 immunostaining has the potential to aid in reducing false-positives at the time of FNA diagnosis of breast disease.","ja":"Myoepithelial cells of the mammary gland are considered to be a key to distinguishing benign from malignant disease in fine-needle aspiration (FNA) cytology. However, identification of these cells with Papanicolaou staining is not easy. The identification of myoepithelial cells was investigated using p63 antibodies to carry out immunostaining of FNA specimens that had been used at the time of Papanicolaou staining for 37 patients who yielded false-positives in FNA. Positively-stained cells were observed in overlying cell clusters or the background in 67.6% of the patients. There is a possibility that over-diagnosis could have been avoided by performing p63 staining for these patients. The controls consisted of stamp samples of fresh specimens obtained from 23 patients at the time of surgery for invasive carcinoma and the results of p63 immunostaining did not reveal any positive staining of tumor cells. Accordingly, these results indicate that there is a strong likelihood that there is no invasive carcinoma when many p63-positive cells are observed in the tumor cell population or the background and that p63 immunostaining has the potential to aid in reducing false-positives at the time of FNA diagnosis of breast disease."},"publication_date":"2006-11","publication_name":{"en":"Anticancer Research","ja":"Anticancer Research"},"volume":"Vol.26","number":"No.6B","starting_page":"4373","ending_page":"4378","languages":["eng"],"referee":true,"identifiers":{"issn":["0250-7005"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/16678603","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=192893","label":"url"}],"paper_title":{"en":"Lung regeneration: implantation of fetal rat lung fragments into adult rat lung parenchyma.","ja":"Lung regeneration: implantation of fetal rat lung fragments into adult rat lung parenchyma."},"authors":{"en":[{"name":"Kenzaki Koichiro"},{"name":"Sakiyama Shoji"},{"name":"Kondo Kazuya"},{"name":"Yoshida Mitsuteru"},{"name":"Kawakami Yukikiyo"},{"name":"Takehisa Masatsugu"},{"name":"Takizawa Hiromitsu"},{"name":"Miyoshi Takanori"},{"name":"Bando Yoshimi"},{"name":"Tangoku Akira"},{"name":"Liu Mingyao"}],"ja":[{"name":"監﨑 孝一郎"},{"name":"先山 正二"},{"name":"近藤 和也"},{"name":"吉田 光輝"},{"name":"Kawakami Yukikiyo"},{"name":"Takehisa Masatsugu"},{"name":"滝沢 宏光"},{"name":"Miyoshi Takanori"},{"name":"坂東 良美"},{"name":"丹黒 章"},{"name":"Liu Mingyao"}]},"description":{"en":"OBJECTIVE: The capability of regeneration of lung tissues in adults is limited after chronic destruction. Bone marrow-derived stem cells, retinoic acid, growth factors, and other approaches have been attempted to promote or facilitate this process. We hypothesized that fetal lung tissues, with great potential for growth and differentiation, could be used for lung regeneration. METHODS: Day 17 fetal lung tissue fragments at the pseudoglandular stage of lung development from Lewis rats were implanted into adult Lewis rat lungs. For group 1, fetal lung fragments were injected into the adult left lung parenchyma; for group 2, fetal fragments were injected with the left lung partially resected; for group 3, adult fragments were injected; and for groups 4 and 5, fetal fragments were implanted into the omentum and subcutaneous tissue, respectively. RESULTS: The grafts implanted into pulmonary parenchyma were differentiated with opening of the alveolar space after 4 weeks and were advanced further with morphologic features similar to those of neonatal lungs after 8 and 12 weeks. The implants were connected with pulmonary circulation determined by means of perfusion with India ink. These changes appeared to be further enhanced in animals with partial lung resection that might have facilitated the maturation of implanted fetal lung tissues through mechanical factors, soluble factors, or both. Fetal lung tissues did not mature when implanted into the omentum or subcutaneous tissue. Adult lung fragments did not expand after being reimplanted back into the same animal. CONCLUSIONS: Fetal lung tissue might be an option for further investigation into lung regeneration.","ja":"OBJECTIVE: The capability of regeneration of lung tissues in adults is limited after chronic destruction. Bone marrow-derived stem cells, retinoic acid, growth factors, and other approaches have been attempted to promote or facilitate this process. We hypothesized that fetal lung tissues, with great potential for growth and differentiation, could be used for lung regeneration. METHODS: Day 17 fetal lung tissue fragments at the pseudoglandular stage of lung development from Lewis rats were implanted into adult Lewis rat lungs. For group 1, fetal lung fragments were injected into the adult left lung parenchyma; for group 2, fetal fragments were injected with the left lung partially resected; for group 3, adult fragments were injected; and for groups 4 and 5, fetal fragments were implanted into the omentum and subcutaneous tissue, respectively. RESULTS: The grafts implanted into pulmonary parenchyma were differentiated with opening of the alveolar space after 4 weeks and were advanced further with morphologic features similar to those of neonatal lungs after 8 and 12 weeks. The implants were connected with pulmonary circulation determined by means of perfusion with India ink. These changes appeared to be further enhanced in animals with partial lung resection that might have facilitated the maturation of implanted fetal lung tissues through mechanical factors, soluble factors, or both. Fetal lung tissues did not mature when implanted into the omentum or subcutaneous tissue. Adult lung fragments did not expand after being reimplanted back into the same animal. CONCLUSIONS: Fetal lung tissue might be an option for further investigation into lung regeneration."},"publication_date":"2006-05","publication_name":{"en":"Journal of Thoracic and Cardiovascular Surgery","ja":"Journal of Thoracic and Cardiovascular Surgery"},"volume":"Vol.131","number":"No.5","starting_page":"1148","ending_page":"1153","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.jtcvs.2005.11.041"],"issn":["1097-685X"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/16628255","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=141060","label":"url"}],"paper_title":{"en":"Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice","ja":"Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice"},"authors":{"en":[{"name":"Niki Shino"},{"name":"Oshikawa Kiyotaka"},{"name":"Mouri Yasuhiro"},{"name":"Hirota Fumiko"},{"name":"Matsushima Akemi"},{"name":"Yano Masashi"},{"name":"Han Hongwei"},{"name":"Bando Yoshimi"},{"name":"Izumi Keisuke"},{"name":"Matsumoto Masaki"},{"name":"Nakayama I. Keiichi"},{"name":"Kuroda Noriyuki"},{"name":"Matsumoto Mitsuru"}],"ja":[{"name":"Niki Shino"},{"name":"Oshikawa Kiyotaka"},{"name":"毛利 安宏"},{"name":"Hirota Fumiko"},{"name":"松島 明美"},{"name":"Yano Masashi"},{"name":"Han Hongwei"},{"name":"坂東 良美"},{"name":"泉 啓介"},{"name":"Matsumoto Masaki"},{"name":"Nakayama I. Keiichi"},{"name":"黒田 範行"},{"name":"松本 満"}]},"description":{"en":"Factors that determine the spectrum of target organs involved in autoimmune destruction are poorly understood. Although loss of function of autoimmune regulator (AIRE) in thymic epithelial cells is responsible for autoimmunity, the pathogenic roles of AIRE in regulating target-organ specificity remain elusive. In order to gain insight into this issue, we have established NOD mice, an animal model of type 1 diabetes caused by autoimmune attack against beta cell islets, in which Aire has been abrogated. Remarkably, acinar cells rather than beta cell islets were the major targets of autoimmune destruction in Aire-deficient NOD mice, and this alteration of intra-pancreatic target-organ specificity was associated with production of autoantibody against pancreas-specific protein disulfide isomerase (PDIp), an antigen expressed predominantly by acinar cells. Consistent with this pathological change, the animals were resistant to the development of diabetes. The results suggest that Aire not only is critical for the control of self-tolerance but is also a strong modifier of target-organ specificity through regulation of T cell repertoire diversification. We also demonstrated that transcriptional expression of PDIp was retained in the Aire-deficient NOD thymus, further supporting the concept that Aire may regulate the survival of autoreactive T cells beyond transcriptional control of self-protein expression in the thymus.","ja":"Factors that determine the spectrum of target organs involved in autoimmune destruction are poorly understood. Although loss of function of autoimmune regulator (AIRE) in thymic epithelial cells is responsible for autoimmunity, the pathogenic roles of AIRE in regulating target-organ specificity remain elusive. In order to gain insight into this issue, we have established NOD mice, an animal model of type 1 diabetes caused by autoimmune attack against beta cell islets, in which Aire has been abrogated. Remarkably, acinar cells rather than beta cell islets were the major targets of autoimmune destruction in Aire-deficient NOD mice, and this alteration of intra-pancreatic target-organ specificity was associated with production of autoantibody against pancreas-specific protein disulfide isomerase (PDIp), an antigen expressed predominantly by acinar cells. Consistent with this pathological change, the animals were resistant to the development of diabetes. The results suggest that Aire not only is critical for the control of self-tolerance but is also a strong modifier of target-organ specificity through regulation of T cell repertoire diversification. We also demonstrated that transcriptional expression of PDIp was retained in the Aire-deficient NOD thymus, further supporting the concept that Aire may regulate the survival of autoreactive T cells beyond transcriptional control of self-protein expression in the thymus."},"publication_date":"2006-05","publication_name":{"en":"The Journal of Clinical Investigation","ja":"The Journal of Clinical Investigation"},"volume":"Vol.116","number":"No.5","starting_page":"1292","ending_page":"1301","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1172/JCI26971"],"issn":["0021-9738"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/16547234","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-33646055527&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=250644","label":"url"}],"paper_title":{"en":"Essential role of IkappaB kinase alpha in thymic organogenesis required for the establishment of self-tolerance.","ja":"Essential role of IkappaB kinase alpha in thymic organogenesis required for the establishment of self-tolerance."},"authors":{"en":[{"name":"Kinoshita Dan"},{"name":"Hirota Fumiko"},{"name":"Kaisho Tsuneyasu"},{"name":"Kasai Michiyuki"},{"name":"Izumi Keisuke"},{"name":"Bando Yoshimi"},{"name":"Mouri Yasuhiro"},{"name":"Matsushima Akemi"},{"name":"Niki Shino"},{"name":"Han Hongwei"},{"name":"Oshikawa Kiyotaka"},{"name":"Kuroda Noriyuki"},{"name":"Maegawa Masahiko"},{"name":"Irahara Minoru"},{"name":"Takeda Kiyoshi"},{"name":"Akira Shizuo"},{"name":"Matsumoto Mitsuru"}],"ja":[{"name":"Kinoshita Dan"},{"name":"廣田 史子"},{"name":"Kaisho Tsuneyasu"},{"name":"笠井 道之"},{"name":"泉 啓介"},{"name":"坂東 良美"},{"name":"毛利 安宏"},{"name":"松島 明美"},{"name":"Niki Shino"},{"name":"Han Hongwei"},{"name":"Oshikawa Kiyotaka"},{"name":"黒田 範行"},{"name":"前川 正彦"},{"name":"苛原 稔"},{"name":"Takeda Kiyoshi"},{"name":"Akira Shizuo"},{"name":"松本 満"}]},"description":{"en":"IkappaB kinase (IKK) alpha exhibits diverse biological activities through protein kinase-dependent and -independent functions, the former mediated predominantly through a noncanonical NF-kappaB activation pathway. The in vivo function of IKKalpha, however, still remains elusive. Because a natural strain of mice with mutant NF-kappaB-inducing kinase (NIK) manifests autoimmunity as a result of disorganized thymic structure with abnormal expression of Rel proteins in the thymic stroma, we speculated that the NIK-IKKalpha axis might constitute an essential step in the thymic organogenesis that is required for the establishment of self-tolerance. An autoimmune disease phenotype was induced in athymic nude mice by grafting embryonic thymus from IKKalpha-deficient mice. The thymic microenvironment that caused autoimmunity in an IKKalpha-dependent manner was associated with defective processing of NF-kappaB2, resulting in the impaired development of thymic epithelial cells. Thus, our results demonstrate a novel function for IKKalpha in thymic organogenesis for the establishment of central tolerance that depends on its protein kinase activity in cooperation with NIK.","ja":"IkappaB kinase (IKK) alpha exhibits diverse biological activities through protein kinase-dependent and -independent functions, the former mediated predominantly through a noncanonical NF-kappaB activation pathway. The in vivo function of IKKalpha, however, still remains elusive. Because a natural strain of mice with mutant NF-kappaB-inducing kinase (NIK) manifests autoimmunity as a result of disorganized thymic structure with abnormal expression of Rel proteins in the thymic stroma, we speculated that the NIK-IKKalpha axis might constitute an essential step in the thymic organogenesis that is required for the establishment of self-tolerance. An autoimmune disease phenotype was induced in athymic nude mice by grafting embryonic thymus from IKKalpha-deficient mice. The thymic microenvironment that caused autoimmunity in an IKKalpha-dependent manner was associated with defective processing of NF-kappaB2, resulting in the impaired development of thymic epithelial cells. Thus, our results demonstrate a novel function for IKKalpha in thymic organogenesis for the establishment of central tolerance that depends on its protein kinase activity in cooperation with NIK."},"publication_date":"2006-04-01","publication_name":{"en":"The Journal of Immunology","ja":"The Journal of Immunology"},"volume":"Vol.176","number":"No.7","starting_page":"3995","ending_page":"4002","languages":["eng"],"referee":true,"identifiers":{"issn":["0022-1767"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/15699112","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=121168","label":"url"}],"paper_title":{"en":"Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice","ja":"Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice"},"authors":{"en":[{"name":"Kuroda Noriyuki"},{"name":"Mitani Tasuku"},{"name":"Takeda Naoki"},{"name":"Ishimaru Naozumi"},{"name":"Arakaki Rieko"},{"name":"Hayashi Yoshio"},{"name":"Bando Yoshimi"},{"name":"Izumi Keisuke"},{"name":"Takahashi Takeshi"},{"name":"Nomura Takashi"},{"name":"Sakaguchi Shimon"},{"name":"Ueno Tomoo"},{"name":"Takahama Yousuke"},{"name":"Uchida Daisuke"},{"name":"Sun Shijie"},{"name":"Kajiura Fumiko"},{"name":"Mouri Yasuhiro"},{"name":"Han Hongwei"},{"name":"Matsushima Akemi"},{"name":"Yamada Gen"},{"name":"Matsumoto Mitsuru"}],"ja":[{"name":"黒田 範行"},{"name":"Mitani Tasuku"},{"name":"Takeda Naoki"},{"name":"石丸 直澄"},{"name":"新垣 理恵子"},{"name":"林 良夫"},{"name":"坂東 良美"},{"name":"泉 啓介"},{"name":"Takahashi Takeshi"},{"name":"Nomura Takashi"},{"name":"Sakaguchi Shimon"},{"name":"上野 智雄"},{"name":"高浜 洋介"},{"name":"内田 大亮"},{"name":"Sun Shijie"},{"name":"Kajiura Fumiko"},{"name":"毛利 安宏"},{"name":"Han Hongwei"},{"name":"松島 明美"},{"name":"Yamada Gen"},{"name":"松本 満"}]},"description":{"en":"Autoimmune regulator (AIRE) gene mutation is responsible for the development of organ-specific autoimmune disease with monogenic autosomal recessive inheritance. Although Aire has been considered to regulate the elimination of autoreactive T cells through transcriptional control of tissue-specific Ags in thymic epithelial cells, other mechanisms of AIRE-dependent tolerance remain to be investigated. We have established Aire-deficient mice and examined the mechanisms underlying the breakdown of self-tolerance. The production and/or function of immunoregulatory T cells were retained in the Aire-deficient mice. The mice developed Sjogren's syndrome-like pathologic changes in the exocrine organs, and this was associated with autoimmunity against a ubiquitous protein, alpha-fodrin. Remarkably, transcriptional expression of alpha-fodrin was retained in the Aire-deficient thymus. These results suggest that Aire regulates the survival of autoreactive T cells beyond transcriptional control of self-protein expression in the thymus, at least against this ubiquitous protein. Rather, Aire may regulate the processing and/or presentation of self-proteins so that the maturing T cells can recognize the self-Ags in a form capable of efficiently triggering autoreactive T cells. With the use of inbred Aire-deficient mouse strains, we also demonstrate the presence of some additional factor(s) that determine the target-organ specificity of the autoimmune disease caused by Aire deficiency.","ja":"Autoimmune regulator (AIRE) gene mutation is responsible for the development of organ-specific autoimmune disease with monogenic autosomal recessive inheritance. Although Aire has been considered to regulate the elimination of autoreactive T cells through transcriptional control of tissue-specific Ags in thymic epithelial cells, other mechanisms of AIRE-dependent tolerance remain to be investigated. We have established Aire-deficient mice and examined the mechanisms underlying the breakdown of self-tolerance. The production and/or function of immunoregulatory T cells were retained in the Aire-deficient mice. The mice developed Sjogren's syndrome-like pathologic changes in the exocrine organs, and this was associated with autoimmunity against a ubiquitous protein, alpha-fodrin. Remarkably, transcriptional expression of alpha-fodrin was retained in the Aire-deficient thymus. These results suggest that Aire regulates the survival of autoreactive T cells beyond transcriptional control of self-protein expression in the thymus, at least against this ubiquitous protein. Rather, Aire may regulate the processing and/or presentation of self-proteins so that the maturing T cells can recognize the self-Ags in a form capable of efficiently triggering autoreactive T cells. With the use of inbred Aire-deficient mouse strains, we also demonstrate the presence of some additional factor(s) that determine the target-organ specificity of the autoimmune disease caused by Aire deficiency."},"publication_date":"2005-02-15","publication_name":{"en":"The Journal of Immunology","ja":"The Journal of Immunology"},"volume":"Vol.174","number":"No.4","starting_page":"1862","ending_page":"1870","languages":["eng"],"referee":true,"identifiers":{"doi":["10.3410/f.1024264.287833"],"issn":["0022-1767"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/15500935","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=127970","label":"url"}],"paper_title":{"en":"Inhibitory effects of Centella asiatica on azoxymethane-induced aberrant crypt focus formation and carcinogenesis in the intestines of F344 rats","ja":"Inhibitory effects of Centella asiatica on azoxymethane-induced aberrant crypt focus formation and carcinogenesis in the intestines of F344 rats"},"authors":{"en":[{"name":"Bunpo Piyawan"},{"name":"Kataoka Keiko"},{"name":"Arimochi Hideki"},{"name":"Nakayama Haruyuki"},{"name":"Kuwahara Tomomi"},{"name":"Bando Yoshimi"},{"name":"Izumi Keisuke"},{"name":"Vinitketkumnuen Usanee"},{"name":"Ohnishi Yoshinari"}],"ja":[{"name":"Bunpo Piyawan"},{"name":"片岡 佳子"},{"name":"有持 秀喜"},{"name":"中山 治之"},{"name":"桑原 知巳"},{"name":"坂東 良美"},{"name":"泉 啓介"},{"name":"Vinitketkumnuen Usanee"},{"name":"大西 克成"}]},"description":{"en":"Effects of the water extract of Centella asiatica Linn. on formation of azoxymethane (AOM)-induced aberrant crypt foci (ACF) and intestinal tumorigenesis in male F344 rats were investigated. Treatment with the extract significantly decreased the number of larger ACF (with four or more crypts per focus) in the large intestine in the early stage, while the number of methylated DNA adducts was not decreased compared with that in the AOM-treated group. In the post-initiation stage, the extract significantly decreased the total number of ACF and the number of larger ACF, accompanied by a decrease in the 5-bromo-2'-deoxyuridine-labeling index and an increase in the induction of apoptotic cells in the colonic mucosa. The incidences of neoplasms, the numbers of adenocarcinomas in the small intestines and entire intestines, and sizes of neoplasms in the entire intestines in rats fed C. asiatica extract at a dose of 10 mg/kg were smaller than those in rats given AOM alone (p < 0.05). The extract at a dose of 100 mg/kg significantly reduced the multiplicity of neoplasms in the small intestine (p < 0.05). These results suggest that inhibition of the formation of AOM-induced ACF by C. asiatica extract is associated with modification of cell proliferation and induction of apoptosis in colonic crypts and that the extract has a chemopreventive effect on colon tumorigenesis.","ja":"Effects of the water extract of Centella asiatica Linn. on formation of azoxymethane (AOM)-induced aberrant crypt foci (ACF) and intestinal tumorigenesis in male F344 rats were investigated. Treatment with the extract significantly decreased the number of larger ACF (with four or more crypts per focus) in the large intestine in the early stage, while the number of methylated DNA adducts was not decreased compared with that in the AOM-treated group. In the post-initiation stage, the extract significantly decreased the total number of ACF and the number of larger ACF, accompanied by a decrease in the 5-bromo-2'-deoxyuridine-labeling index and an increase in the induction of apoptotic cells in the colonic mucosa. The incidences of neoplasms, the numbers of adenocarcinomas in the small intestines and entire intestines, and sizes of neoplasms in the entire intestines in rats fed C. asiatica extract at a dose of 10 mg/kg were smaller than those in rats given AOM alone (p < 0.05). The extract at a dose of 100 mg/kg significantly reduced the multiplicity of neoplasms in the small intestine (p < 0.05). These results suggest that inhibition of the formation of AOM-induced ACF by C. asiatica extract is associated with modification of cell proliferation and induction of apoptosis in colonic crypts and that the extract has a chemopreventive effect on colon tumorigenesis."},"publication_date":"2004-12","publication_name":{"en":"Food and Chemical Toxicology","ja":"Food and Chemical Toxicology"},"volume":"Vol.42","number":"No.12","starting_page":"1987","ending_page":"1997","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.fct.2004.06.022"],"issn":["0278-6915"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/15504957","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=112399","label":"url"}],"paper_title":{"en":"Platelet-derived growth factor stimulates glucose transport in skeletal muscles of transgenic mice specifically expressing PDGF receptor in the muscle, but does not affect blood glucose levels","ja":"Platelet-derived growth factor stimulates glucose transport in skeletal muscles of transgenic mice specifically expressing PDGF receptor in the muscle, but does not affect blood glucose levels"},"authors":{"en":[{"name":"Yuasa Tomoyuki"},{"name":"Kakuhata Rei"},{"name":"Kishi Kazuhiro"},{"name":"Obata Toshiyuki"},{"name":"Shinohara Yasuo"},{"name":"Bando Yoshimi"},{"name":"Izumi Keisuke"},{"name":"Kajiura Fumiko"},{"name":"Matsumoto Mitsuru"},{"name":"Ebina Yousuke"}],"ja":[{"name":"湯浅 智之"},{"name":"Kakuhata Rei"},{"name":"岸 和弘"},{"name":"小畑 利之"},{"name":"篠原 康雄"},{"name":"坂東 良美"},{"name":"泉 啓介"},{"name":"Kajiura Fumiko"},{"name":"松本 満"},{"name":"蛯名 洋介"}]},"description":{"en":"Insulin stimulates the disposal of blood glucose into skeletal muscle and adipose tissues by the translocation of GLUT4 from intracellular pools to the plasma membrane, and consequently the concentration of blood glucose levels decreases rapidly in vivo. Phosphatidylinositol (PI) 3-kinase and Akt play a pivotal role in the stimulation of glucose transport by insulin, but detailed mechanisms are unknown. We and others reported that not only insulin but also platelet-derived growth factor (PDGF) and epidermal growth factor facilitate glucose uptake through GLUT4 translocation by activation of PI 3-kinase and Akt in cultured cells. However, opposite results were also reported. We generated transgenic mice that specifically express the PDGF receptor in skeletal muscle. In these mice, PDGF stimulated glucose transport into skeletal muscle in vitro and in vivo. Thus, PDGF apparently shares with insulin some of the signaling molecules needed for the stimulation of glucose transport. The degree of glucose uptake in vivo reached approximately 60% of that by insulin injection in skeletal muscle, but blood glucose levels were not decreased by PDGF in these mice. Therefore, PDGF-induced disposal of blood glucose into skeletal muscle is insufficient for rapid decrease of blood glucose levels.","ja":"Insulin stimulates the disposal of blood glucose into skeletal muscle and adipose tissues by the translocation of GLUT4 from intracellular pools to the plasma membrane, and consequently the concentration of blood glucose levels decreases rapidly in vivo. Phosphatidylinositol (PI) 3-kinase and Akt play a pivotal role in the stimulation of glucose transport by insulin, but detailed mechanisms are unknown. We and others reported that not only insulin but also platelet-derived growth factor (PDGF) and epidermal growth factor facilitate glucose uptake through GLUT4 translocation by activation of PI 3-kinase and Akt in cultured cells. However, opposite results were also reported. We generated transgenic mice that specifically express the PDGF receptor in skeletal muscle. In these mice, PDGF stimulated glucose transport into skeletal muscle in vitro and in vivo. Thus, PDGF apparently shares with insulin some of the signaling molecules needed for the stimulation of glucose transport. The degree of glucose uptake in vivo reached approximately 60% of that by insulin injection in skeletal muscle, but blood glucose levels were not decreased by PDGF in these mice. Therefore, PDGF-induced disposal of blood glucose into skeletal muscle is insufficient for rapid decrease of blood glucose levels."},"publication_date":"2004-11","publication_name":{"en":"Diabetes","ja":"Diabetes"},"volume":"Vol.53","number":"No.11","starting_page":"2776","ending_page":"2786","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2337/diabetes.53.11.2776"],"issn":["0012-1797"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/15118262","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=82580","label":"url"}],"paper_title":{"en":"KATP Channel Knockout Mice Crossbred with Transgenic Mice Expressing a Dominant-Negative Form of Human Insulin Receptor have Glucose Intolerance but not Diabetes","ja":"KATP Channel Knockout Mice Crossbred with Transgenic Mice Expressing a Dominant-Negative Form of Human Insulin Receptor have Glucose Intolerance but not Diabetes"},"authors":{"en":[{"name":"Kanezaki Yoshiko"},{"name":"Obata Toshiyuki"},{"name":"Matsushima Rie"},{"name":"Minami Asako"},{"name":"Yuasa Tomoyuki"},{"name":"Kishi Kazuhiro"},{"name":"Bando Yoshimi"},{"name":"Uehara Hisanori"},{"name":"Izumi Keisuke"},{"name":"Mitani Tasuku"},{"name":"Matsumoto Mitsuru"},{"name":"Takeshita Yukari"},{"name":"Nakaya Yutaka"},{"name":"Matsumoto Toshio"},{"name":"Ebina Yousuke"}],"ja":[{"name":"金崎 淑子"},{"name":"小畑 利之"},{"name":"松嶋 理恵"},{"name":"南 麻子"},{"name":"湯浅 智之"},{"name":"岸 和弘"},{"name":"坂東 良美"},{"name":"上原 久典"},{"name":"泉 啓介"},{"name":"三谷 匡"},{"name":"松本 満"},{"name":"竹下 ゆかり"},{"name":"中屋 豊"},{"name":"松本 俊夫"},{"name":"蛯名 洋介"}]},"description":{"en":"Impaired insulin secretion and insulin resistance are thought to be two major causes of type 2 diabetes mellitus. There are two kinds of diabetic model mice: one is a K(ATP) channel knockout (Kir6.2KO) mouse which is defective in glucose-induced insulin secretion, and the other is a transgenic mouse expressing the tyrosine kinase-deficient (dominant-negative form of) human insulin receptor (hIR(KM)TG), and which has insulin resistance in muscle and fat. However, all of these mice have no evidence of overt diabetes. To determine if the double mutant Kir6.2KO/hIR(KM)TG mice would have diabetes, we generated mutant mice by crossbreeding, which would show both impaired glucose-induced insulin secretion and insulin resistance in muscle and fat. We report here that: 1) blood glucose levels of randomly fed and 6 h fasted double mutant (Kir6.2KO/hIR(KM)TG) mice were comparable with those of wild type mice; 2) in intraperitoneal glucose tolerance test (ipGTT), Kir6.2KO/hIR(KM)TG mice had an impaired glucose tolerance; and 3) during ipGTT, insulin secretion was not induced in either Kir6.2KO/hIR(KM)TG or Kir6.2KO mice, while the hIR(KM)TG mice showed a more prolonged insulin secretion than did wild type mice; 4) hyperinsulinemic euglycemic clamp test revealed that Kir6.2KO, Kir6.2KO/hIR(KM)TG and hIR(KM)TG mice, showed decreased whole-body glucose disposal compared with wild type mice; 5) Kir6.2KO, but not Kir6.2KO/hIR(KM)TG mice had some obesity and hyperleptinemia compared with wild type mice. Thus, the defects in glucose-induced insulin secretion (Kir6.2KO) and an insulin resistance in muscle and fat (hIR(KM)TG) were not sufficient to lead to overt diabetes.","ja":"Impaired insulin secretion and insulin resistance are thought to be two major causes of type 2 diabetes mellitus. There are two kinds of diabetic model mice: one is a K(ATP) channel knockout (Kir6.2KO) mouse which is defective in glucose-induced insulin secretion, and the other is a transgenic mouse expressing the tyrosine kinase-deficient (dominant-negative form of) human insulin receptor (hIR(KM)TG), and which has insulin resistance in muscle and fat. However, all of these mice have no evidence of overt diabetes. To determine if the double mutant Kir6.2KO/hIR(KM)TG mice would have diabetes, we generated mutant mice by crossbreeding, which would show both impaired glucose-induced insulin secretion and insulin resistance in muscle and fat. We report here that: 1) blood glucose levels of randomly fed and 6 h fasted double mutant (Kir6.2KO/hIR(KM)TG) mice were comparable with those of wild type mice; 2) in intraperitoneal glucose tolerance test (ipGTT), Kir6.2KO/hIR(KM)TG mice had an impaired glucose tolerance; and 3) during ipGTT, insulin secretion was not induced in either Kir6.2KO/hIR(KM)TG or Kir6.2KO mice, while the hIR(KM)TG mice showed a more prolonged insulin secretion than did wild type mice; 4) hyperinsulinemic euglycemic clamp test revealed that Kir6.2KO, Kir6.2KO/hIR(KM)TG and hIR(KM)TG mice, showed decreased whole-body glucose disposal compared with wild type mice; 5) Kir6.2KO, but not Kir6.2KO/hIR(KM)TG mice had some obesity and hyperleptinemia compared with wild type mice. Thus, the defects in glucose-induced insulin secretion (Kir6.2KO) and an insulin resistance in muscle and fat (hIR(KM)TG) were not sufficient to lead to overt diabetes."},"publication_date":"2004-04","publication_name":{"en":"Endocrine Journal","ja":"Endocrine Journal"},"volume":"Vol.51","number":"No.2","starting_page":"133","ending_page":"144","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1507/endocrj.51.133"],"issn":["0918-8959"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/14764671","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=121167","label":"url"}],"paper_title":{"en":"NF-κB-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner","ja":"NF-κB-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner"},"authors":{"en":[{"name":"Kajiura Fumiko"},{"name":"Sun Shijie"},{"name":"Nomura Takashi"},{"name":"Izumi Keisuke"},{"name":"Ueno Tomoo"},{"name":"Bando Yoshimi"},{"name":"Kuroda Noriyuki"},{"name":"Han Hongwei"},{"name":"Li Yi"},{"name":"Matsushima Akemi"},{"name":"Takahama Yousuke"},{"name":"Sakaguchi Shimon"},{"name":"Mitani Tasuku"},{"name":"Matsumoto Mitsuru"}],"ja":[{"name":"Kajiura Fumiko"},{"name":"Sun Shijie"},{"name":"Nomura Takashi"},{"name":"泉 啓介"},{"name":"上野 智雄"},{"name":"坂東 良美"},{"name":"黒田 範行"},{"name":"Han Hongwei"},{"name":"Li Yi"},{"name":"松島 明美"},{"name":"高浜 洋介"},{"name":"Sakaguchi Shimon"},{"name":"Mitani Tasuku"},{"name":"松本 満"}]},"description":{"en":"Physical contact between thymocytes and the thymic stroma is essential for T cell maturation and shapes the T cell repertoire in the periphery. Stromal elements that control these processes still remain elusive. We used a mouse strain with mutant NF-kappaB-inducing kinase (NIK) to examine the mechanisms underlying the breakdown of self-tolerance. This NIK-mutant strain manifests autoimmunity and disorganized thymic structure with abnormal expression of Rel proteins in the stroma. Production of immunoregulatory T cells that control autoreactive T cells was impaired in NIK-mutant mice. The autoimmune disease seen in NIK-mutant mice was reproduced in athymic nude mice by grafting embryonic thymus from NIK-mutant mice, and this was rescued by supply of exogenous immunoregulatory T cells. Impaired production of immunoregulatory T cells by thymic stroma without normal NIK was associated with altered expression of peripheral tissue-restricted Ags, suggesting an essential role of NIK in the thymic microenvironment in the establishment of central tolerance.","ja":"Physical contact between thymocytes and the thymic stroma is essential for T cell maturation and shapes the T cell repertoire in the periphery. Stromal elements that control these processes still remain elusive. We used a mouse strain with mutant NF-kappaB-inducing kinase (NIK) to examine the mechanisms underlying the breakdown of self-tolerance. This NIK-mutant strain manifests autoimmunity and disorganized thymic structure with abnormal expression of Rel proteins in the stroma. Production of immunoregulatory T cells that control autoreactive T cells was impaired in NIK-mutant mice. The autoimmune disease seen in NIK-mutant mice was reproduced in athymic nude mice by grafting embryonic thymus from NIK-mutant mice, and this was rescued by supply of exogenous immunoregulatory T cells. Impaired production of immunoregulatory T cells by thymic stroma without normal NIK was associated with altered expression of peripheral tissue-restricted Ags, suggesting an essential role of NIK in the thymic microenvironment in the establishment of central tolerance."},"publication_date":"2004-02-15","publication_name":{"en":"The Journal of Immunology","ja":"The Journal of Immunology"},"volume":"Vol.172","number":"No.4","starting_page":"2067","ending_page":"2075","languages":["eng"],"referee":true,"identifiers":{"issn":["0022-1767"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/14643918","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=374571","label":"url"}],"paper_title":{"en":"Complicated paraneoplastic neurological syndromes: a report of two patients with small cell or non-small cell lung cancer","ja":"Complicated paraneoplastic neurological syndromes: a report of two patients with small cell or non-small cell lung cancer"},"authors":{"en":[{"name":"Hiasa Yukiko"},{"name":"Kunishige Makoto"},{"name":"Mitsui Takao"},{"name":"Kondo Shunsuke"},{"name":"Kuriwaka Rika"},{"name":"Shigekiyo Shizuka"},{"name":"Kanematsu Takanori"},{"name":"Satake Nobuo"},{"name":"Bando Yoshimi"},{"name":"Kondo Akira"},{"name":"Endo Itsuro"},{"name":"Oshima Yasushi"},{"name":"Matsumoto Toshio"}],"ja":[{"name":"Hiasa Yukiko"},{"name":"Kunishige Makoto"},{"name":"三ツ井 貴夫"},{"name":"Kondo Shunsuke"},{"name":"Kuriwaka Rika"},{"name":"Shigekiyo Shizuka"},{"name":"Kanematsu Takanori"},{"name":"Satake Nobuo"},{"name":"坂東 良美"},{"name":"Kondo Akira"},{"name":"遠藤 逸朗"},{"name":"大島 康志"},{"name":"松本 俊夫"}]},"description":{"en":"Paraneoplastic neurological syndromes are frequently associated in patients with small cell lung cancer (SCLC) and antineuronal antibodies are involved in the autoimmune mechanism. Multiple syndromes are sometimes complicated in a single patient with SCLC. However, little is known about non-SCLC-associated neurological manifestations. We report two patients with complicated paraneoplastic neurological syndromes. Patient 1 showed paraneoplastic limbic encephalitis (PLE), paraneoplastic sensory neuropathy (PSN) and Lambert-Eaton myasthenic syndrome (LEMS) associated with SCLC. Patient 2 developed opsoclonus-ataxia and probable PLE associated with non-SCLC. Analysis of various antineuronal antibodies revealed that anti-Hu and P/Q-type voltage-gated calcium channel (VGCC) antibodies were positive in Patient 1 but any antibodies were not in Patient 2. Brain MRI demonstrated high intensity signals in temporal lobes particularly on fluid-attenuated inversion recovery (FLAIR) or diffusion-weighted images. These findings suggest that complicated paraneoplastic neurological syndromes occur in non-SCLC as well as SCLC and that unidentified antineuronal autoantibodies may underlie the pathophysiology.","ja":"Paraneoplastic neurological syndromes are frequently associated in patients with small cell lung cancer (SCLC) and antineuronal antibodies are involved in the autoimmune mechanism. Multiple syndromes are sometimes complicated in a single patient with SCLC. However, little is known about non-SCLC-associated neurological manifestations. We report two patients with complicated paraneoplastic neurological syndromes. Patient 1 showed paraneoplastic limbic encephalitis (PLE), paraneoplastic sensory neuropathy (PSN) and Lambert-Eaton myasthenic syndrome (LEMS) associated with SCLC. Patient 2 developed opsoclonus-ataxia and probable PLE associated with non-SCLC. Analysis of various antineuronal antibodies revealed that anti-Hu and P/Q-type voltage-gated calcium channel (VGCC) antibodies were positive in Patient 1 but any antibodies were not in Patient 2. Brain MRI demonstrated high intensity signals in temporal lobes particularly on fluid-attenuated inversion recovery (FLAIR) or diffusion-weighted images. These findings suggest that complicated paraneoplastic neurological syndromes occur in non-SCLC as well as SCLC and that unidentified antineuronal autoantibodies may underlie the pathophysiology."},"publication_date":"2003-12","publication_name":{"en":"Clinical Neurology and Neurosurgery","ja":"Clinical Neurology and Neurosurgery"},"volume":"Vol.106","number":"No.12","starting_page":"47","ending_page":"49","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/s0303-8467(03)00059-3"],"issn":["0303-8467"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/14578283","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=75247","label":"url"}],"paper_title":{"en":"Increased Insulin Sensitivity and Hypoinsulinemia in APS Knockout Mice","ja":"Increased Insulin Sensitivity and Hypoinsulinemia in APS Knockout Mice"},"authors":{"en":[{"name":"Minami Asako"},{"name":"Iseki Masanori"},{"name":"Kishi Kazuhiro"},{"name":"Wang Miao"},{"name":"Ogura Makoto"},{"name":"Furukawa Noboru"},{"name":"Hayashi Sanae"},{"name":"Yamada Mizuki"},{"name":"Obata Toshiyuki"},{"name":"Takeshita Yukari"},{"name":"Nakaya Yutaka"},{"name":"Bando Yoshimi"},{"name":"Izumi Keisuke"},{"name":"Moodie A Shonna"},{"name":"Kajiura Fumiko"},{"name":"Matsumoto Mitsuru"},{"name":"Takatsu Kiyoshi"},{"name":"Takaki Satoshi"},{"name":"Ebina Yousuke"}],"ja":[{"name":"南 麻子"},{"name":"Iseki Masanori"},{"name":"岸 和弘"},{"name":"Wang Miao"},{"name":"Ogura Makoto"},{"name":"古川 昇"},{"name":"Hayashi Sanae"},{"name":"Yamada Mizuki"},{"name":"小畑 利之"},{"name":"Takeshita Yukari"},{"name":"中屋 豊"},{"name":"坂東 良美"},{"name":"泉 啓介"},{"name":"Moodie A Shonna"},{"name":"Kajiura Fumiko"},{"name":"松本 満"},{"name":"Takatsu Kiyoshi"},{"name":"Takaki Satoshi"},{"name":"蛯名 洋介"}]},"description":{"en":"A tyrosine kinase adaptor protein containing pleckstrin homology and SH2 domains (APS) is rapidly and strongly tyrosine phosphorylated by insulin receptor kinase upon insulin stimulation. The function of APS in insulin signaling has heretofore remained unknown. APS-deficient (APS(-/-)) mice were used to investigate its function in vivo. The blood glucose-lowering effect of insulin, as assessed by the intraperitoneal insulin tolerance test, was increased in APS(-/-) mice. Plasma insulin levels during fasting and in the intraperitoneal glucose tolerance test were lower in APS(-/-) mice. APS(-/-) mice showed an increase in the whole-body glucose infusion rate as assessed by the hyperinsulinemic-euglycemic clamp test. These findings indicated that APS(-/-) mice exhibited increased sensitivity to insulin. However, overexpression of wild-type or dominant-negative APS in 3T3L1 adipocytes did not affect insulin receptor numbers, phosphorylations of insulin receptor, insulin receptor substrate-1, or Akt and mitogen-activated protein kinase. The glucose uptake and GLUT4 translocation were not affected by insulin stimulation in these cells. Nevertheless, the insulin-stimulated glucose transport in isolated adipocytes of APS(-/-) mice was increased over that of APS(+/+) mice. APS(-/-) mice also showed increased serum levels of leptin and adiponectin, which might explain the increased insulin sensitivity of adipocytes.","ja":"A tyrosine kinase adaptor protein containing pleckstrin homology and SH2 domains (APS) is rapidly and strongly tyrosine phosphorylated by insulin receptor kinase upon insulin stimulation. The function of APS in insulin signaling has heretofore remained unknown. APS-deficient (APS(-/-)) mice were used to investigate its function in vivo. The blood glucose-lowering effect of insulin, as assessed by the intraperitoneal insulin tolerance test, was increased in APS(-/-) mice. Plasma insulin levels during fasting and in the intraperitoneal glucose tolerance test were lower in APS(-/-) mice. APS(-/-) mice showed an increase in the whole-body glucose infusion rate as assessed by the hyperinsulinemic-euglycemic clamp test. These findings indicated that APS(-/-) mice exhibited increased sensitivity to insulin. However, overexpression of wild-type or dominant-negative APS in 3T3L1 adipocytes did not affect insulin receptor numbers, phosphorylations of insulin receptor, insulin receptor substrate-1, or Akt and mitogen-activated protein kinase. The glucose uptake and GLUT4 translocation were not affected by insulin stimulation in these cells. Nevertheless, the insulin-stimulated glucose transport in isolated adipocytes of APS(-/-) mice was increased over that of APS(+/+) mice. APS(-/-) mice also showed increased serum levels of leptin and adiponectin, which might explain the increased insulin sensitivity of adipocytes."},"publication_date":"2003-11","publication_name":{"en":"Diabetes","ja":"Diabetes"},"volume":"Vol.52","number":"No.11","starting_page":"2657","ending_page":"2665","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2337/diabetes.52.11.2657"],"issn":["0012-1797"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=164420","label":"url"}],"paper_title":{"en":"空腹時の血漿インスリン濃度は常に低値で,グルカゴンにより著明なインスリン分泌反応が誘導されたインスリノーマの1例","ja":"空腹時の血漿インスリン濃度は常に低値で,グルカゴンにより著明なインスリン分泌反応が誘導されたインスリノーマの1例"},"authors":{"en":[{"name":"新谷 保実"},{"name":"Fujinaka Yuichi"},{"name":"高橋 幸志"},{"name":"伊藤 祐司"},{"name":"加藤 修司"},{"name":"Inoue Daisuke"},{"name":"Matsumoto Toshio"},{"name":"Kurita Nobuhiro"},{"name":"Tashiro Seiki"},{"name":"Bando Yoshimi"},{"name":"Sano Toshiaki"},{"name":"宮 恵子"}],"ja":[{"name":"新谷 保実"},{"name":"藤中 雄一"},{"name":"高橋 幸志"},{"name":"伊藤 祐司"},{"name":"加藤 修司"},{"name":"井上 大輔"},{"name":"松本 俊夫"},{"name":"栗田 信浩"},{"name":"田代 征記"},{"name":"坂東 良美"},{"name":"佐野 壽昭"},{"name":"宮 恵子"}]},"publication_date":"2003","publication_name":{"en":"糖尿病","ja":"糖尿病"},"volume":"Vol.46","number":"No.8","starting_page":"679","ending_page":"684","languages":["jpn"],"referee":true,"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12688680&dopt=Abstract","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/12688680","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=146357","label":"url"}],"paper_title":{"en":"Phosphorylation, but not overexpression, of epidermal growth factor receptor is associated with poor prognosis of non-small cell lung cancer patients","ja":"Phosphorylation, but not overexpression, of epidermal growth factor receptor is associated with poor prognosis of non-small cell lung cancer patients"},"authors":{"en":[{"name":"Kanematsu Takanori"},{"name":"Yano Seiji"},{"name":"Uehara Hisanori"},{"name":"Bando Yoshimi"},{"name":"Sone Saburo"}],"ja":[{"name":"Kanematsu Takanori"},{"name":"矢野 聖二"},{"name":"上原 久典"},{"name":"坂東 良美"},{"name":"曽根 三郎"}]},"description":{"en":"Epidermal growth factor receptor (EGFR) is commonly overexpressed in non-small cell lung cancer (NSCLC) and its tyrosine kinase phosphorylation is thought to be an ideal target in the treatment of patients with NSCLC. In the present study, we examined surgically obtained specimens from a series of 36 NSCLC patients for expression of EGFR, phosphorylated EGFR (p-EGFR), and HER2 by immunohistochemistry, and also examined the correlation with clinical characteristics. The positive rate of EGFR, p-EGFR, and HER2 was 97.2%, 44.4%, and 88.6%, respectively, and the overexpression rate was 80.6%, 0.0%, and 27.8%, respectively. EGFR overexpression and phosphorylation were seen at almost the same rate in each histological type of squamous and nonsquamous cell carcinoma (squamous vs. nonsquamous; 78.6% vs. 81.8% for EGFR, 35.7% vs. 50.0% for p-EGFR), while HER2 overexpression was seen less frequently in squamous cell carcinoma than in nonsquamous cell carcinoma (0.0% vs. 45.5%, P = 0.003). Univariate analysis revealed that EGFR overexpression was related to good performance status (P = 0.038) but not related to EGFR phosphorylation. EGFR phosphorylation was correlated to short time to progression (TTP) (P = 0.002) and poor prognosis (P = 0.002), although EGFR overexpression, HER2 overexpression, or EGFR-HER2 coexpression were not correlated to TTP or survival. Bivariate analysis showed EGFR phosphorylation was related to short TTP and poor prognosis both in early and advanced stages. Multivariate analyses confirmed that clinical stage, performance status, and p-EGFR expression were independently associated with increasing risk of short TTP and poor prognosis. These results suggest that phosphorylation, but not overexpression, of EGFR may be an important predictor for clinical outcome of NSCLCs.","ja":"Epidermal growth factor receptor (EGFR) is commonly overexpressed in non-small cell lung cancer (NSCLC) and its tyrosine kinase phosphorylation is thought to be an ideal target in the treatment of patients with NSCLC. In the present study, we examined surgically obtained specimens from a series of 36 NSCLC patients for expression of EGFR, phosphorylated EGFR (p-EGFR), and HER2 by immunohistochemistry, and also examined the correlation with clinical characteristics. The positive rate of EGFR, p-EGFR, and HER2 was 97.2%, 44.4%, and 88.6%, respectively, and the overexpression rate was 80.6%, 0.0%, and 27.8%, respectively. EGFR overexpression and phosphorylation were seen at almost the same rate in each histological type of squamous and nonsquamous cell carcinoma (squamous vs. nonsquamous; 78.6% vs. 81.8% for EGFR, 35.7% vs. 50.0% for p-EGFR), while HER2 overexpression was seen less frequently in squamous cell carcinoma than in nonsquamous cell carcinoma (0.0% vs. 45.5%, P = 0.003). Univariate analysis revealed that EGFR overexpression was related to good performance status (P = 0.038) but not related to EGFR phosphorylation. EGFR phosphorylation was correlated to short time to progression (TTP) (P = 0.002) and poor prognosis (P = 0.002), although EGFR overexpression, HER2 overexpression, or EGFR-HER2 coexpression were not correlated to TTP or survival. Bivariate analysis showed EGFR phosphorylation was related to short TTP and poor prognosis both in early and advanced stages. Multivariate analyses confirmed that clinical stage, performance status, and p-EGFR expression were independently associated with increasing risk of short TTP and poor prognosis. These results suggest that phosphorylation, but not overexpression, of EGFR may be an important predictor for clinical outcome of NSCLCs."},"publication_date":"2003","publication_name":{"en":"Oncology Research","ja":"Oncology Research"},"volume":"Vol.13","number":"No.5","starting_page":"289","ending_page":"298","languages":["eng"],"referee":true,"identifiers":{"issn":["0965-0407"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"http://www.springerlink.com/link.asp?id=r21mtxq4180rdlgp","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/11037355","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-0033829680&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=91119","label":"url"}],"paper_title":{"en":"So-called mesothelial/monocytic incidental cardiac excrescences obtained during valve replacement surgery: report of three cases and literature review.","ja":"So-called mesothelial/monocytic incidental cardiac excrescences obtained during valve replacement surgery: report of three cases and literature review."},"authors":{"en":[{"name":"Bando Yoshimi"},{"name":"Kitagawa Tetsuya"},{"name":"Uehara Hisanori"},{"name":"Sano Nobuya"},{"name":"Satake Nobuo"},{"name":"Onose Y"},{"name":"Kitaichi Takashi"},{"name":"Miki Osamu"},{"name":"Katoh Itsuo"},{"name":"Izumi Keisuke"}],"ja":[{"name":"坂東 良美"},{"name":"北川 哲也"},{"name":"上原 久典"},{"name":"佐野 暢哉"},{"name":"Satake Nobuo"},{"name":"Onose Y"},{"name":"北市 隆"},{"name":"Miki Osamu"},{"name":"Katoh Itsuo"},{"name":"泉 啓介"}]},"description":{"en":"We present three cases of so-called mesothelial/monocytic incidental cardiac excrescences (MICE) of the heart and a brief review of related literature. Case 1 was a 51-year-old woman who underwent mitral- and aortic-valve replacement. A tissue sample was submitted as a thrombus attached to the left atrial endocardium. Case 2 was a 69-year-old woman who underwent mitral-valve replacement. The sample was incidentally obtained as whitish clot-like fragments, but its exact origin was not known. Case 3 was a 68-year-old woman who underwent mitral-valve replacement for suspected infective endocarditis. The sample adherent to the pericardium was removed after valvular surgery. Histologically, these lesions were composed of a mixture of plump histiocytoid cells, a papillary arrangement of cuboidal cells, various sized vacuoles, and fibrin. The nests of cuboidal cells resembled cancer cells but showed features of mesothelial cells and no proliferative activity, immunohistochemically or ultrastructurally. In all cases, a suction tube placed in the left atrium was occasionally used to remove overflowing intrapericardial fluid during the surgery. The tip of the suction tube was covered with spiral wire, which is likely to transfer the stripped pericardial mesothelial cells to the left atrium. The significance of MICE is their possibility of being misdiagnosed as metastatic carcinoma by pathologists and a risk of arterial embolization by mesothelial debris clinically.","ja":"We present three cases of so-called mesothelial/monocytic incidental cardiac excrescences (MICE) of the heart and a brief review of related literature. Case 1 was a 51-year-old woman who underwent mitral- and aortic-valve replacement. A tissue sample was submitted as a thrombus attached to the left atrial endocardium. Case 2 was a 69-year-old woman who underwent mitral-valve replacement. The sample was incidentally obtained as whitish clot-like fragments, but its exact origin was not known. Case 3 was a 68-year-old woman who underwent mitral-valve replacement for suspected infective endocarditis. The sample adherent to the pericardium was removed after valvular surgery. Histologically, these lesions were composed of a mixture of plump histiocytoid cells, a papillary arrangement of cuboidal cells, various sized vacuoles, and fibrin. The nests of cuboidal cells resembled cancer cells but showed features of mesothelial cells and no proliferative activity, immunohistochemically or ultrastructurally. In all cases, a suction tube placed in the left atrium was occasionally used to remove overflowing intrapericardial fluid during the surgery. The tip of the suction tube was covered with spiral wire, which is likely to transfer the stripped pericardial mesothelial cells to the left atrium. The significance of MICE is their possibility of being misdiagnosed as metastatic carcinoma by pathologists and a risk of arterial embolization by mesothelial debris clinically."},"publication_date":"2000-09","publication_name":{"en":"Virchows Archiv","ja":"Virchows Archiv"},"volume":"Vol.437","number":"No.3","starting_page":"331","ending_page":"335","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s004280000232"],"issn":["0945-6317"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"http://ci.nii.ac.jp/naid/10008090440/","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/10391088","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1570854174670742656/","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-0033025144&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=88915","label":"url"}],"paper_title":{"en":"Effects of D-galactosamine hydrochloride and partial hepatectomy on spontaneous hepatic injury and hepatocarcinogenesis in Long-Evans Cinnamon rats","ja":"Effects of D-galactosamine hydrochloride and partial hepatectomy on spontaneous hepatic injury and hepatocarcinogenesis in Long-Evans Cinnamon rats"},"authors":{"en":[{"name":"Jiao, Zhongxian"},{"name":"Ohnishi Takamasa"},{"name":"Bando Yoshimi"},{"name":"Chone, Yoshifumi"},{"name":"Kitaura, Keisuke"},{"name":"Uehara Hisanori"},{"name":"Suzuki, Yasuo"},{"name":"Nakamura, Toshikazu"},{"name":"Izumi Keisuke"}],"ja":[{"name":"Jiao, Zhongxian"},{"name":"大西 隆仁"},{"name":"坂東 良美"},{"name":"Chone, Yoshifumi"},{"name":"Kitaura, Keisuke"},{"name":"上原 久典"},{"name":"Suzuki, Yasuo"},{"name":"Nakamura, Toshikazu"},{"name":"泉 啓介"}]},"publication_date":"1999-05","publication_name":{"en":"Japanese Journal of Cancer Research","ja":"Japanese Journal of Cancer Research"},"volume":"Vol.90","number":"No.5","starting_page":"496","ending_page":"504","languages":["eng"],"referee":true,"identifiers":{"issn":["0910-5050"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=91137","label":"url"}],"paper_title":{"en":"Mechanisms of generation of oxygen radicals and reductive mobilization of ferritin iron by lipoamide dehydrogenase.","ja":"Mechanisms of generation of oxygen radicals and reductive mobilization of ferritin iron by lipoamide dehydrogenase."},"authors":{"en":[{"name":"Bando Yoshimi"},{"name":"Kenji Aki"}],"ja":[{"name":"坂東 良美"},{"name":"Kenji Aki"}]},"publication_date":"1991","publication_name":{"en":"The Journal of Biochemistry","ja":"The Journal of Biochemistry"},"volume":"Vol.109","starting_page":"450","ending_page":"454","languages":["eng"],"referee":true,"identifiers":{"issn":["0021-924X"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=91136","label":"url"}],"paper_title":{"en":"Superoxide-mediated release of iron from ferritin by some flavoenzymes.","ja":"Superoxide-mediated release of iron from ferritin by some flavoenzymes."},"authors":{"en":[{"name":"Bando Yoshimi"},{"name":"Aki Kenji"}],"ja":[{"name":"坂東 良美"},{"name":"Aki Kenji"}]},"publication_date":"1990-04-30","publication_name":{"en":"Biochemical and Biophysical Research Communications","ja":"Biochemical and Biophysical Research Communications"},"volume":"Vol.168","number":"No.2","starting_page":"389","ending_page":"395","languages":["eng"],"referee":true,"identifiers":{"issn":["0006-291X"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"http://repo.lib.tokushima-u.ac.jp/116860","label":"url"},{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116860","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1050010293735891072/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=390120","label":"url"}],"paper_title":{"en":"研究に関する男女共同参画・ダイバーシティの推進状況に関するアンケート調査-全国の集計結果との比較から見える徳島大学の現状-","ja":"研究に関する男女共同参画・ダイバーシティの推進状況に関するアンケート調査-全国の集計結果との比較から見える徳島大学の現状-"},"authors":{"en":[{"name":"Izawa-Ishizawa Yuki"},{"name":"Bando Yoshimi"},{"name":"Sumitani Satsuki"},{"name":"Tangoku Akira"},{"name":"Haku Mari"}],"ja":[{"name":"石澤 有紀"},{"name":"坂東 良美"},{"name":"住谷 さつき"},{"name":"丹黒 章"},{"name":"葉久 真理"}]},"description":{"en":"本調査では,全国ダイバーシティネットワークの幹事機関である大阪大学と,日本学術会議科学者委員会男女共同参画分科会・同アンケート検討小分科会が共同で実施した「大学・研究機関における男女共同参画・ダイバーシティの推進状況調査」のうち「大学・研究機関における男女共同参画の推進状況に対する意見・感想」について,徳島大学回答分(男性60 件,女性21 件)のみ抽出されたデータを用いて,本学における男女共同参画・ダイバーシティ推進に関する研究者の意識調査を実施した.男女別に集計し,公開されている全国集計結果(計10,105 件)と比較検討することで,全国における本学の位置付けについて分析した. 調査項目は, 1 .男女共同参画の推進(全般) 2 .男女共同参画の取り組み 3 .ワークライフバランス・育児支援サービス 4 .ダイバーシティ対応 5 .ハラスメント防止体制 6 .医学系 の6 項目にわたる.全国と徳島での回答差,また男女間の回答差から,現在の徳島大学の研究者における男女共同参画に対する意識について考察する.","ja":"本調査では,全国ダイバーシティネットワークの幹事機関である大阪大学と,日本学術会議科学者委員会男女共同参画分科会・同アンケート検討小分科会が共同で実施した「大学・研究機関における男女共同参画・ダイバーシティの推進状況調査」のうち「大学・研究機関における男女共同参画の推進状況に対する意見・感想」について,徳島大学回答分(男性60 件,女性21 件)のみ抽出されたデータを用いて,本学における男女共同参画・ダイバーシティ推進に関する研究者の意識調査を実施した.男女別に集計し,公開されている全国集計結果(計10,105 件)と比較検討することで,全国における本学の位置付けについて分析した. 調査項目は, 1 .男女共同参画の推進(全般) 2 .男女共同参画の取り組み 3 .ワークライフバランス・育児支援サービス 4 .ダイバーシティ対応 5 .ハラスメント防止体制 6 .医学系 の6 項目にわたる.全国と徳島での回答差,また男女間の回答差から,現在の徳島大学の研究者における男女共同参画に対する意識について考察する."},"publication_date":"2022-03","publication_name":{"en":"徳島大学人と地域共創センター紀要","ja":"徳島大学人と地域共創センター紀要"},"volume":"Vol.31","starting_page":"17","ending_page":"32","languages":["jpn"],"identifiers":{"issn":["2435-1822"]},"published_paper_type":"research_institution"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"http://search.jamas.or.jp/link/ui/2021006247","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1391130851445583872/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=377525","label":"url"}],"paper_title":{"en":"同時性・異時性に多発した小児脂肪芽腫の1例","ja":"同時性・異時性に多発した小児脂肪芽腫の1例"},"authors":{"en":[{"name":"Yokota Noriko"},{"name":"Ishibashi Hiroki"},{"name":"Mori Hiroki"},{"name":"Shimada Mitsuo"},{"name":"遠藤 秀子"},{"name":"Bando Yoshimi"}],"ja":[{"name":"横田 典子"},{"name":"石橋 広樹"},{"name":"森 大樹"},{"name":"島田 光生"},{"name":"遠藤 秀子"},{"name":"坂東 良美"}]},"description":{"en":"症例は3歳,男児.両側鼠径部外側と右背部の紡錘状の皮下腫瘤を認めたため,当科紹介受診となった.外来で経過観察を行っていたが,その後,左腋窩部及び右季肋部にも同様の皮下腫瘤が出現した.非典型的に多発し,悪性の可能性も否定できなかったため,背部皮下腫瘤を摘出し,脂肪芽腫と診断した.残りの4ヶ所を追加で切除したところ,最初の病変と同様に,脂肪芽細胞や小型の脂肪細胞を認め,同時・異時性に多発した脂肪芽腫と診断した.術後,約1年半が経過しているが,新たな腫瘤の発生や再発は認めていない.脂肪芽腫では,発見後の早期摘出が一般的であるが,稀に本症例のような多発例が存在することも念頭におき,早期摘出後も慎重な経過観察が必要であると思われた.(著者抄録)","ja":"症例は3歳,男児.両側鼠径部外側と右背部の紡錘状の皮下腫瘤を認めたため,当科紹介受診となった.外来で経過観察を行っていたが,その後,左腋窩部及び右季肋部にも同様の皮下腫瘤が出現した.非典型的に多発し,悪性の可能性も否定できなかったため,背部皮下腫瘤を摘出し,脂肪芽腫と診断した.残りの4ヶ所を追加で切除したところ,最初の病変と同様に,脂肪芽細胞や小型の脂肪細胞を認め,同時・異時性に多発した脂肪芽腫と診断した.術後,約1年半が経過しているが,新たな腫瘤の発生や再発は認めていない.脂肪芽腫では,発見後の早期摘出が一般的であるが,稀に本症例のような多発例が存在することも念頭におき,早期摘出後も慎重な経過観察が必要であると思われた.(著者抄録)"},"publication_date":"2020-10","publication_name":{"en":"Journal of the Japanese Society of Pediatric Surgeons","ja":"日本小児外科学会雑誌"},"volume":"Vol.56","number":"No.6","starting_page":"988","ending_page":"991","languages":["jpn"],"identifiers":{"doi":["10.11164/jjsps.56.6_988"],"issn":["0288-609X"]},"published_paper_type":"research_institution"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/31704828","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=361185","label":"url"}],"paper_title":{"en":"Carbohydrate Antigen 19-9 Is a Prognostic Factor Which Correlates With HDAC1 and HIF-1 for Intrahepatic Cholangiocarcinoma.","ja":"Carbohydrate Antigen 19-9 Is a Prognostic Factor Which Correlates With HDAC1 and HIF-1 for Intrahepatic Cholangiocarcinoma."},"authors":{"en":[{"name":"Oota Shogo"},{"name":"Morine Yuji"},{"name":"Imura Satoru"},{"name":"Ikemoto Tetsuya"},{"name":"Arakawa Yusuke"},{"name":"Iwahashi Shuichi"},{"name":"Saitou Yu"},{"name":"Yamada Shin-ichiro"},{"name":"Wada Yuuma"},{"name":"Iwahashi Shoko"},{"name":"Bando Yoshimi"},{"name":"Shimada Mitsuo"}],"ja":[{"name":"太田 昇吾"},{"name":"森根 裕二"},{"name":"居村 暁"},{"name":"池本 哲也"},{"name":"荒川 悠佑"},{"name":"岩橋 衆一"},{"name":"齋藤 裕"},{"name":"山田 眞一郎"},{"name":"和田 佑馬"},{"name":"岩橋 祥子"},{"name":"坂東 良美"},{"name":"島田 光生"}]},"description":{"en":"Carbohydrate antigen 19-9 (CA19-9) is a poor prognostic marker in intrahepatic cholangiocarcinoma (IHCC). Previous studies have shown a link between hypoxia and CA19-9 in cancer, and we have previously demonstrated a correlation between HDAC1 and HIF-1 in IHCC. Here, we evaluated the expression and correlation of CA19-9 with HIF-1 and HDAC in IHCC. This study included 62 patients with IHCC who underwent primary hepatectomy at our department. Clinicopathological characteristics were examined. Immunohistochemical expression of HIF-1 and HDAC1 in specimens was quantitatively evaluated. Patients with high preoperative serum CA19-9 levels showed clinicopathological characteristics associated with tumour progression. High CA19-9 levels were associated with worse overall and recurrence-free survival. Univariate and multivariate analysis detected high CA19-9 levels as an independent poor prognostic factor for IHCC. Serum CA19-9 was significantly correlated with both HIF-1 and HDAC1 expression. High serum CA19-9 level is a poor prognostic factor for overall survival in IHCC and correlates with HIF-1 and HDAC1 expression.","ja":"Carbohydrate antigen 19-9 (CA19-9) is a poor prognostic marker in intrahepatic cholangiocarcinoma (IHCC). Previous studies have shown a link between hypoxia and CA19-9 in cancer, and we have previously demonstrated a correlation between HDAC1 and HIF-1 in IHCC. Here, we evaluated the expression and correlation of CA19-9 with HIF-1 and HDAC in IHCC. This study included 62 patients with IHCC who underwent primary hepatectomy at our department. Clinicopathological characteristics were examined. Immunohistochemical expression of HIF-1 and HDAC1 in specimens was quantitatively evaluated. Patients with high preoperative serum CA19-9 levels showed clinicopathological characteristics associated with tumour progression. High CA19-9 levels were associated with worse overall and recurrence-free survival. Univariate and multivariate analysis detected high CA19-9 levels as an independent poor prognostic factor for IHCC. Serum CA19-9 was significantly correlated with both HIF-1 and HDAC1 expression. High serum CA19-9 level is a poor prognostic factor for overall survival in IHCC and correlates with HIF-1 and HDAC1 expression."},"publication_date":"2019-11","publication_name":{"en":"Anticancer Research","ja":"Anticancer Research"},"volume":"Vol.39","number":"No.11","starting_page":"6025","ending_page":"6033","languages":["eng"],"identifiers":{"doi":["10.21873/anticanres.13808"],"issn":["1791-7530"]},"published_paper_type":"research_institution"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/31292813","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=361180","label":"url"}],"paper_title":{"en":"A case of gastric heterotopic pancreas with gastroduodenal invagination.","ja":"A case of gastric heterotopic pancreas with gastroduodenal invagination."},"authors":{"en":[{"name":"Iwahashi Shoko"},{"name":"Nishi Masaaki"},{"name":"Yoshimoto Toshiaki"},{"name":"Kashihara Hideya"},{"name":"Takasu Chie"},{"name":"Tokunaga Takuya"},{"name":"Miyatani Tomohiko"},{"name":"Higashijima Jun"},{"name":"Yoshikawa Kouzou"},{"name":"Wada Yuuma"},{"name":"Bando Yoshimi"},{"name":"Shimada Mitsuo"}],"ja":[{"name":"岩橋 祥子"},{"name":"西 正暁"},{"name":"良元 俊昭"},{"name":"柏原 秀也"},{"name":"髙須 千絵"},{"name":"徳永 卓哉"},{"name":"宮谷 知彦"},{"name":"東島 潤"},{"name":"吉川 幸造"},{"name":"和田 佑馬"},{"name":"坂東 良美"},{"name":"島田 光生"}]},"description":{"en":"Heterotopic pancreas (HP) is a rare disease commonly found incidentally on imaging studies, at endoscopy or at autopsy and can be associated with abdominal pain, vomiting, heart burn, gastric outlet obstruction, and even dysphagia in very rare cases. Heinrich's classified HP into three groups, types1-3, with Heinrich's type 3 HP the rarest and difficult to diagnose properly because it has only pancreatic ducts but has no islet and acini. The aim of this study is to report a case of gastric outlet obstruction caused by type 3 HP with gastroduodenal invagination with reference to the literature and diagnosed finally by immuno-histochemical analysis. The case presented is a 40-year-old male presenting with vomiting and abdominal pain. Computed tomography (CT) revealed a cystic mass in the upper abdomen and he was referred to the Tokushima University. Gastric fiber showed that the pedunculated mass originated from the stomach. An open distal gastrectomy was performed. Pathologically, there was small glands proliferation in the sub-mucosal (SM) layer which was membrane and cytoplasm (MUC)1 positive and muscle proliferation. This finding revealed the tumor as HP. Postoperative course was uneventful and the patient was discharged 12 days after surgery. The patient has remained well 12 months after surgery. HP should be considered in the differential diagnosis of SM tumors with gastroduodenal invagination even if this is a rare symptom.","ja":"Heterotopic pancreas (HP) is a rare disease commonly found incidentally on imaging studies, at endoscopy or at autopsy and can be associated with abdominal pain, vomiting, heart burn, gastric outlet obstruction, and even dysphagia in very rare cases. Heinrich's classified HP into three groups, types1-3, with Heinrich's type 3 HP the rarest and difficult to diagnose properly because it has only pancreatic ducts but has no islet and acini. The aim of this study is to report a case of gastric outlet obstruction caused by type 3 HP with gastroduodenal invagination with reference to the literature and diagnosed finally by immuno-histochemical analysis. The case presented is a 40-year-old male presenting with vomiting and abdominal pain. Computed tomography (CT) revealed a cystic mass in the upper abdomen and he was referred to the Tokushima University. Gastric fiber showed that the pedunculated mass originated from the stomach. An open distal gastrectomy was performed. Pathologically, there was small glands proliferation in the sub-mucosal (SM) layer which was membrane and cytoplasm (MUC)1 positive and muscle proliferation. This finding revealed the tumor as HP. Postoperative course was uneventful and the patient was discharged 12 days after surgery. The patient has remained well 12 months after surgery. HP should be considered in the differential diagnosis of SM tumors with gastroduodenal invagination even if this is a rare symptom."},"publication_date":"2019-07-10","publication_name":{"en":"Surgical Case Reports","ja":"Surgical Case Reports"},"volume":"Vol.5","number":"No.1","starting_page":"110","ending_page":"110","languages":["eng"],"identifiers":{"doi":["10.1186/s40792-019-0669-7"],"issn":["2198-7793"]},"published_paper_type":"research_institution"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/109697","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/24965572","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=296207","label":"url"}],"paper_title":{"en":"High STAT4 expression is a better prognostic indicator in patients with hepatocellular carcinoma after hepatectomy.","ja":"High STAT4 expression is a better prognostic indicator in patients with hepatocellular carcinoma after hepatectomy."},"authors":{"en":[{"name":"Wubetu Yismaw Gizachew"},{"name":"Utsunomiya Tohru"},{"name":"Ishikawa Daichi"},{"name":"Yamada Shinichiro"},{"name":"Ikemoto Tetsuya"},{"name":"Morine Yuji"},{"name":"Iwahashi Shuichi"},{"name":"Saitou Yu"},{"name":"Arakawa Yusuke"},{"name":"Imura Satoru"},{"name":"Kanamoto Mami"},{"name":"Zhu Chengzhan"},{"name":"Bando Yoshimi"},{"name":"Shimada Mitsuo"}],"ja":[{"name":"Wubetu Yismaw Gizachew"},{"name":"Utsunomiya Tohru"},{"name":"Ishikawa Daichi"},{"name":"Yamada Shinichiro"},{"name":"池本 哲也"},{"name":"森根 裕二"},{"name":"岩橋 衆一"},{"name":"齋藤 裕"},{"name":"荒川 悠佑"},{"name":"居村 暁"},{"name":"金本 真美"},{"name":"Zhu Chengzhan"},{"name":"坂東 良美"},{"name":"島田 光生"}]},"description":{"en":"Signal transducer and activator of transcription 4 (STAT4) mediates the intracellular effects of interleukin-12, leading to the production of interferon gamma (IFN-γ) and natural killer cells cytotoxicity. However, the clinical significance of STAT4 expression in patients with hepatocellular carcinoma (HCC) remains virtually unknown. A total of 66 HCC patients who underwent hepatectomy were enrolled in this study. Quantitative real-time polymerase chain reaction was performed to determine STAT4 and IFNG mRNA expression levels. Tissue microarray-based immunohistochemistry was performed to examine CD8(+) T cells, STAT4, and INF-γ proteins. STAT4 was differentially expressed in tumor and nontumor tissues (P = 0.001) and positively correlated with IFNG expression (R (2) = 0.506, P < 0.05) and CD8(+) T cell infiltration (R (2) = 0.53, P < 0.001). Significant correlations were observed between STAT4 expression and tumor TNM stage (P = 0.043), hepatic venous invasion (P = 0.003), des-gamma-carboxy prothrombin (P = 0.011), tumor size (P = 0.036), and tumor differentiation (P = 0.034). Patients with high STAT4 expression had significantly better recurrence-free survival (P = 0.009). Low STAT4 expression (P = 0.030) and presence of portal venous invasion or hepatic venous invasion (P = 0.006) were independent risk factors for HCC recurrence. Downregulation of STAT4 in HCC indicated aggressive tumor behavior and predicted a worse clinical outcome. STAT4 might be a useful biomarker to identify patients at high risk of recurrence after hepatectomy.","ja":"Signal transducer and activator of transcription 4 (STAT4) mediates the intracellular effects of interleukin-12, leading to the production of interferon gamma (IFN-γ) and natural killer cells cytotoxicity. However, the clinical significance of STAT4 expression in patients with hepatocellular carcinoma (HCC) remains virtually unknown. A total of 66 HCC patients who underwent hepatectomy were enrolled in this study. Quantitative real-time polymerase chain reaction was performed to determine STAT4 and IFNG mRNA expression levels. Tissue microarray-based immunohistochemistry was performed to examine CD8(+) T cells, STAT4, and INF-γ proteins. STAT4 was differentially expressed in tumor and nontumor tissues (P = 0.001) and positively correlated with IFNG expression (R (2) = 0.506, P < 0.05) and CD8(+) T cell infiltration (R (2) = 0.53, P < 0.001). Significant correlations were observed between STAT4 expression and tumor TNM stage (P = 0.043), hepatic venous invasion (P = 0.003), des-gamma-carboxy prothrombin (P = 0.011), tumor size (P = 0.036), and tumor differentiation (P = 0.034). Patients with high STAT4 expression had significantly better recurrence-free survival (P = 0.009). Low STAT4 expression (P = 0.030) and presence of portal venous invasion or hepatic venous invasion (P = 0.006) were independent risk factors for HCC recurrence. Downregulation of STAT4 in HCC indicated aggressive tumor behavior and predicted a worse clinical outcome. STAT4 might be a useful biomarker to identify patients at high risk of recurrence after hepatectomy."},"publication_date":"2014-06-26","publication_name":{"en":"Annals of Surgical Oncology","ja":"Annals of Surgical Oncology"},"volume":"Vol.21 Suppl 4","starting_page":"S721","ending_page":"8","languages":["eng"],"identifiers":{"doi":["10.1245/s10434-014-3861-9"],"issn":["1534-4681"]},"published_paper_type":"research_institution"},"priority":"input_data"} {"insert":{"user_id":"1000242739","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/77529","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/20299759","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=232763","label":"url"}],"paper_title":{"en":"Long-term recurrence-free survivor after laparoscopic removal of solitary adrenal metastasis from endometrial adenocarcinoma.","ja":"Long-term recurrence-free survivor after laparoscopic removal of solitary adrenal metastasis from endometrial adenocarcinoma."},"authors":{"en":[{"name":"Izaki Hirofumi"},{"name":"Takahashi Masayuki"},{"name":"Shiirevnyamba Avirmed"},{"name":"Taue Ryuichi"},{"name":"Furumoto Hiroyuki"},{"name":"Bando Yoshimi"},{"name":"Murakami Yoshihide"},{"name":"Fukawa Tomoya"},{"name":"Koizumi Takahiro"},{"name":"Yamamoto Yasuyo"},{"name":"Yamaguchi Kunihisa"},{"name":"Nakatsuji Hiroyoshi"},{"name":"Kishimoto Tomoteru"},{"name":"Fukumori Tomoharu"},{"name":"Kanayama Hiro-omi"}],"ja":[{"name":"井崎 博文"},{"name":"高橋 正幸"},{"name":"Shiirevnyamba Avirmed"},{"name":"田上 隆一"},{"name":"古本 博孝"},{"name":"坂東 良美"},{"name":"Murakami Yoshihide"},{"name":"布川 朋也"},{"name":"小泉 貴裕"},{"name":"山本 恭代"},{"name":"山口 邦久"},{"name":"中逵 弘能"},{"name":"岸本 大輝"},{"name":"福森 知治"},{"name":"金山 博臣"}]},"description":{"en":"Solitary adrenal metastasis from endometrial adenocarcinoma is extremely rare. We report herein the case of a laparoscopically resected solitary adrenal metastasis originating from endometrial adenocarcinoma. The patient was a 55-year-old woman who had undergone total abdominal hysterectomy for stage IIIc endometrial carcinoma, followed by 7 courses of adjuvant chemotherapy comprising carboplatin and paclitaxel. However, the patient developed an isolated right adrenal metastasis 15 months postoperatively. The solitary adrenal metastasis (diameter, 5.7 cm) was removed laparoscopically. The patient has now been in good health without recurrence for 5 years and 7 months after laparoscopic surgery. To the best of our knowledge, this is the first case of solitary adrenal metastasis originating from endometrial adenocarcinoma that is controlled for the long term by successful laparoscopic resection.","ja":"Solitary adrenal metastasis from endometrial adenocarcinoma is extremely rare. We report herein the case of a laparoscopically resected solitary adrenal metastasis originating from endometrial adenocarcinoma. The patient was a 55-year-old woman who had undergone total abdominal hysterectomy for stage IIIc endometrial carcinoma, followed by 7 courses of adjuvant chemotherapy comprising carboplatin and paclitaxel. However, the patient developed an isolated right adrenal metastasis 15 months postoperatively. The solitary adrenal metastasis (diameter, 5.7 cm) was removed laparoscopically. The patient has now been in good health without recurrence for 5 years and 7 months after laparoscopic surgery. To the best of our knowledge, this is the first case of solitary adrenal metastasis originating from endometrial adenocarcinoma that is controlled for the long term by successful laparoscopic resection."},"publication_date":"2010-02","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.57","number":"No.1-2","starting_page":"174","ending_page":"177","languages":["eng"],"identifiers":{"doi":["10.2152/jmi.57.174"],"issn":["1349-6867"]},"published_paper_type":"research_institution"},"priority":"input_data"}