type: misc

label: url

en: 最新育児小児病学(改訂第7版)

ja: 最新育児小児病学(改訂第7版)


en: Ⅵ.発達障害,心身症,精神疾患. 22.憤怒けいれん.

ja: Ⅵ.発達障害,心身症,精神疾患. 22.憤怒けいれん.

en: Japanese Journal of Pediatric Medicine

ja: 小児内科


en: [てんかん] ピンポイント小児医療 てんかんの診断 青年期以降にみられるてんかん.

en: 小児内科


en: [けいれん・意識障害] ピンポイント小児医療 てんかん，脳の機能的疾患 憤怒けいれん


en: [扁桃体-up to date] 扁桃体とその病態 自閉症スペクトラムにおける扁桃体

en: Clinical Neuroscience

ja: Clinical Neuroscience


en: Neuroimaging in autism

ja: 自閉症の画像研究

en: Psychiatria et neurologia paediatrica Japonica

ja: 小児の精神と神経


en: Neuroimaging of stroke-like episodes in MELAS.

en: Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) shows sudden neurological deficits that are called 'stroke-like episodes'. With regard to the pathophysiology of stroke-like episodes, so-called mitochondrial angiopathy and cytopathy theories have been proposed, but the subject is still controversial. To clarify this matter and to contribute to the development of a treatment for MELAS, we review here current neuroimaging research and consider the pathophysiology of stroke-like lesions. With regard to diffusion-weighted imaging findings, early reports often showed an elevated apparent diffusion coefficient (ADC) in stroke-like lesions; this was considered to be mainly vasogenic edema in the acute phase and is a different pattern than that in stroke. However, there has recently been an increase in the number of reports of a decrease in ADC; these cases are considered to be cytotoxic edema in the acute phase, which is compatible with stroke. With regard to (1)H-magnetic resonance spectroscopy findings in stroke-like lesions, a decrease in N-acetylaspartate and an increase in lactate have been reported. With regard to single photon emission computed tomography findings for stroke-like lesions in MELAS, an overall trend is hyperperfusion in the acute stage (within 1 month) of stroke-like episodes and hypoperfusion in the chronic stage (several months later). With regard to positron emission tomography, nearly all of these reports are consistent with the mitochondrial cytopathy theory. With regard to neuropathology in MELAS, the most common findings during the chronic stage of stroke-like episodes include foci of necrosis and peculiar vascular changes (abnormalities of mitochondria in small arteries). Concerning the pathology of the acute stage of stroke-like episodes, extensive petechial hemorrhage along the gyri of the cortex corresponding to acute stroke-like lesions has been reported. To clarify the true pathophysiology of stroke-like episodes, we offer three suggestions. First, we must define the precise onset of stroke-like episodes. Second, current studies are limited by the difficulty of imaging just before and just after (within a few minutes) the onset of stroke-like episodes. Third, we hope to establish an experimental animal model. We should conduct a simultaneous multimodal imaging and histological study just before and just after (within a few minutes) the onset of stroke-like episodes in an experimental animal model.

en: Brain & Development

ja: Brain & Development


en: Mild cognitive dysfunction and nuclear neurology

ja: 軽度認知障害と脳核医学

en: Clinical Electroencephalography

ja: 臨床脳波


en: 疾患に対する薬剤の選び方・使い方と注意:自閉症

ja: 疾患に対する薬剤の選び方・使い方と注意:自閉症


en: 自閉症スペクトラムへの対応ー児の将来を年頭に:医療的対応

ja: 自閉症スペクトラムへの対応ー児の将来を年頭に:医療的対応

en: 脳と発達

ja: 脳と発達


en: 令和4年度 徳島大学高等教育研究センターアドミッション部門 報告書

ja: 令和4年度 徳島大学高等教育研究センターアドミッション部門 報告書

en: 令和4年度 徳島大学高等教育研究センターアドミッション部門 報告書

ja: 令和4年度 徳島大学高等教育研究センターアドミッション部門 報告書

misc_type: others