type: misc

label: url

en: Roles of histone acetylation sites in cardiac hypertrophy and heart failure.

en: Heart failure results from various physiological and pathological stimuli that lead to cardiac hypertrophy. This pathological process is common in several cardiovascular diseases and ultimately leads to heart failure. The development of cardiac hypertrophy and heart failure involves reprogramming of gene expression, a process that is highly dependent on epigenetic regulation. Histone acetylation is dynamically regulated by cardiac stress. Histone acetyltransferases play an important role in epigenetic remodeling in cardiac hypertrophy and heart failure. The regulation of histone acetyltransferases serves as a bridge between signal transduction and downstream gene reprogramming. Investigating the changes in histone acetyltransferases and histone modification sites in cardiac hypertrophy and heart failure will provide new therapeutic strategies to treat these diseases. This review summarizes the association of histone acetylation sites and histone acetylases with cardiac hypertrophy and heart failure, with emphasis on histone acetylation sites.

en: Frontiers in Cardiovascular Medicine

ja: Frontiers in Cardiovascular Medicine


en: The role of iron in obesity and diabetes.

en: Iron is an essential trace metal for all life, but excess iron causes oxidative stress through catalyzing the toxic hydroxy-radical production via the Fenton reaction. The number of patients with obesity and diabetes has been increasing worldwide, and their onset and development are affected by diet. In both clinical and experimental studies, a high body iron content was associated with obesity and diabetes, and the reduction of body iron content to an appropriate level can ameliorate the status and development of obesity and diabetes. Macrophages play an essential role in the pathophysiology of obesity and diabetes, and in the metabolism and homeostasis of iron in the body. Recent studies demonstrated that macrophage polarization is related to adipocyte hypertrophy and insulin resistance through their capabilities of iron handling. Control of iron in macrophages is a potential therapeutic strategy for obesity and diabetes. J. Med. Invest. 69 : 1-7, February, 2022.

en: The Journal of Medical Investigation : JMI


en: 効果的な実務実習に向けたアクティブ・ラーニングの取り組み

ja: 効果的な実務実習に向けたアクティブ・ラーニングの取り組み

en: Medicine and Drug Journal

ja: 医薬ジャーナル


en: Drug development for cardiorenal disease based on oxidative stress control

ja: 酸化ストレス制御を基盤とする新規心腎血管障害治療薬の開発

en: Oxidative stress is a key factor involved in the pathogenesis and progression of cardiovascular disease (CVD) and chronic kidney disease (CKD). Reactive oxygen species (ROS), produced as a result of redox reactions in various cells, have been recognized as key chemical mediators causing cellular damage and organ dysfunction in CVD and CKD. Nifedipine, a well-known calcium channel blocker, is extremely sensitive to light which gets converted to its nitroso analog, nitrosonifedipine (NO-NIF) in the presence of ultraviolet and visible light. The so formed NO-NIF blocks calcium channel quite weakly compared to that of nifedipine. However, we elucidated for the first time that NO-NIF is converted to NO-NIF radical which acquires extremely strong antioxidant property via reaction with unsaturated fatty acid or endothelial cells. We have already reported that NO-NIF reduces the cytotoxicity of cumene hydroperoxide, which hampers the integrity of cell membrane through oxidative stress, in endothelial cells. Additionally, we demonstrated that NO-NIF restored acetylcholine-responsive vascular relaxation and suppressed intercellular adhesion molecule-1 expression in the aorta of N(ω)-nitro-L-arginine methyl ester-treated rats, a model of vascular endothelial dysfunction. Recently, we reported that NO-NIF ameliorates angiotensin II-induced vascular remodeling via antioxidative effects in vivo and in vitro. These observations point towards the plausible, unique role of NO-NIF as a novel antioxidant which improves vascular dysfunction for overcoming CVD and CKD and the same has been highlighted in this review.

en: Journal of the Pharmaceutical Society of Japan

ja: 薬学雑誌


en: Role of Dietary Essential Trace Metals in the Pathogenesis of Diabetes Mellitus

ja: 糖尿病と食事由来金属元素

en: Journal of the The Japan Diabetes Society

ja: 糖尿病


en: Iron metabolism in the progression of adipocyte hypertrophy

en: The Cell

ja: 細胞


en: The role of iron on cardiovascular disease and diabetes mellitus

ja: 循環器疾患と糖尿病における生体内鉄の意義

en: Japanese Journal of Circulation Research

ja: 血管


en: インスリン抵抗性に対するロサルタンおよびロサルタンと運動の併用による効果-モデルラットを用いたin vivoでの検討-

en: 第17回 健康医科学 研究助成論文集

ja: 第17回 健康医科学 研究助成論文集

misc_type: others