type: misc

label: url

en: Cowden症候群(IV. 各論 消化管ポリポーシス).

ja: Cowden症候群(IV. 各論 消化管ポリポーシス).

en: Nihon Rinsho. Japanese Journal of Clinical Medicine

ja: 日本臨牀


en: 【小腸疾患-診断・治療の最新動向-】消化管ポリポーシス Cowden症候群

ja: 【小腸疾患-診断・治療の最新動向-】消化管ポリポーシス Cowden症候群


en: Recent Advances in Molecular Imaging of Colorectal Tumors.

en: Recent endoscopic studies have revealed that small colorectal tumors are often overlooked during colonoscopy, indicating that more sensitive detection methods are needed. Molecular imaging has received considerable attention as a new endoscopic technique with high sensitivity. It generally employs a fluorescence-labeled compound that specifically binds to a molecule on the tumor. Fluorescent probes for molecular imaging are largely classified as 2 types: a fluorescence-labeled antibody targeting a molecule specifically expressed on the tumor cell surface such as epidermal growth factor receptor or vascular endothelial growth factor (VEGF); and a fluorescence-labeled small molecule compound targeting a molecule specifically expressed in tumor cells including c-Met, glutathione S-transferase, γ-glutamyltranspeptidase, cathepsin, or endothelin A receptor. These probes successfully detected colorectal tumors in several animal studies. Moreover, 3 recent human clinical trials evaluating endoscopic molecular imaging for colorectal tumors have been reported. In one study, a Cy5-labeled synthetic peptide against c-Met was developed, and fluorescent endoscopic observation with this probe detected a greater number of colorectal adenomas than with white light observation. Another trial used IR800-labeled anti-VEGF antibody, which sensitively detected human colorectal adenomas by fluorescent endoscopy. Last, a fluorescent probe with synthetic peptide against BRAF-positive cells was able to visualize sessile serrated lesions. The fluorescent probes accumulated at very high levels in colorectal tumor cells but at lower levels in surrounding nonneoplastic mucosa. Key Messages: We expect that molecular imaging techniques with fluorescent probes will soon lead to the establishment of a highly sensitive endoscopic method for colorectal tumor detection.

en: Digestion

ja: Digestion


en: 小児・成人のためのCowden症候群/PTEN過誤腫症候群診療ガイドライン(2020年版)

en: Journal of Hereditary Tumors

ja: 遺伝性腫瘍


en: Recent Advances in Endoscopic Molecular Imaging of Gastrointestinal Cancer

ja: 総説 がんを標的とした内視鏡分子イメージングの新展開

en: OPTRONICS

ja: OPTRONICS


en: 【消化器疾患のバイオマーカーの有用性と将来】食道癌の診断マーカーの将来

ja: 【消化器疾患のバイオマーカーの有用性と将来】食道癌の診断マーカーの将来

en: 消化器・肝臓内科

ja: 消化器・肝臓内科


en: 【リンチ症候群と遺伝性消化管ポリポーシス】遺伝性消化管ポリポーシス Cowden症候群

en: <文献概要>Cowden症候群は,皮膚・粘膜,消化管,乳腺,甲状腺など全身臓器に過誤腫性病変が多発する常染色体優性遺伝性疾患である.顔面小丘疹,口腔粘膜乳頭腫などの特徴的な皮膚病変を呈し,食道から直腸にいたる全消化管にポリポーシスを高率に合併する.食道に多発する白色扁平隆起は本症の特徴的な所見である.また乳癌などの悪性腫瘍を合併する例も多く,適切なサーベイランスが重要である.診断は,皮膚病変,悪性腫瘍,家族歴などを契機に行われる.有病率は20∼25万人に1人と推定されているが,見逃されている症例も少なくない.原因遺伝子の一つとしてPTEN遺伝子が同定されており,約80

en: Clinical Gastroenterology

ja: 臨床消化器内科


en: 維持透析患者に対する胃瘻造設とその後の管理

ja: 維持透析患者に対する胃瘻造設とその後の管理

en: 高松市民病院雑誌

ja: 高松市民病院雑誌


en: 胃癌の内視鏡治療

ja: 胃癌の内視鏡治療

en: The Japanese journal of clinical and experimental medicine

ja: 臨床と研究


en: Endoscopic molecular imaging:current status and future perspectives

ja: 内視鏡分子イメージングの現況と展望

en: Gastroenterological Endoscopy

ja: Gastroenterological Endoscopy


en: 大腸癌の疫学と基礎 大腸鋸歯状病変のメカニズム.

ja: 大腸癌の疫学と基礎 大腸鋸歯状病変のメカニズム.

en: 臨牀消化器内科

ja: 臨牀消化器内科


en: Dysplasiaを伴うBarrett食道に対する内視鏡診断および治療 --- 欧米における現状と課題

en: 臨床消化器内科


en: Technique and emerging role of cryotherapy.

en: Techniques in Gastrointestinal Endoscopy


en: Principle and Clinical Usefulness of the Infrared Fluorescence Endoscopy

en: Since there is no infrared fluorescence materials in the living body, infrared fluorescence labeling materials are very useful for making a diagnosis of a micro cancer. We have developed an infrared fluorescence endoscope (IRFE) and indocyanin green (ICG)-derivative as infrared fluorescence labeling materials to evaluate gastrointestinal neoplastic lesions. The study aims were to apply an IRFE and to demonstrate its usefulness in detecting cancerous tissue using an antibody coupled with ICG-derivative. IRFE consisted of an infrared endoscope equipped with excitation (710-790 nm) and barrier (810-920 nm) filters and an intensified CCD camera. We have developed ICG N-hydroxy sulfo succinimide ester (ICG-sulfo-OSu) and 3-ICG-acyl-1, 3-thiazolidine-2-thione (ICG-ATT) as an infrared fluorescent-labeling reagent. ICG-derivative-labeled mouse anti-human carcinoembryonic antigen (CEA) antibody and MUC1 antibody were employed in this study. Moreover, we examined the ability of a reinforcement agent, octylglucoside, to intensity fluorescence from the labeled antibody. Biopsy specimens of gastric cancer were stained with anti-CEA antibody by the avidin-biotinylated peroxidase complex method. Among the positive specimens, freshly resected stomach from three cases were used for the infrared (IR) imaging analysis. The incubation of freshly resected stomach specimens with ICG-anti-CEA antibody-complex resulted in positive staining of the tumor sites by IRFE, and the IR fluorescent images correlated well with the tumor sites. The immunohistochemical studies suggested that the intensity of IR fluorescence of ICG-ATT-MUC1 was stronger than that of ICG-sulfo-OSu. In tumor sections, the reinforcement agent intensified fluorescence, ever at low antibody concentrations. Therefore, we conclude that an anti-CEA (and/or MUC1) antibody with affinity for cancerous lesions and labeled with ICG-derivative can be imaged with this IRFE. Specific antibodies tagged with ICG-derivative with the reinforcement agent can label cancer cells and generate a strong enough fluorescent signal to detect small cancers when examined with an IR fluorescence endoscope.

en: The Journal of Medical Investigation : JMI


en: 赤外線蛍光内視鏡の原理と応用

ja: 赤外線蛍光内視鏡の原理と応用

en: Biomedical THERMOLOGY

ja: Biomedical THERMOLOGY


en: データ解説

ja: データ解説

en: Frontiers in Gastroenterology

ja: Frontiers in Gastroenterology


en: 女性ホルモン·エストラジオールの肝発癌抑制作用

ja: 女性ホルモン·エストラジオールの肝発癌抑制作用

en: 性差医学

ja: 性差医学


en: 好酸球性胆管炎の1例

ja: 好酸球性胆管炎の1例

en: 超音波検査技術

ja: 超音波検査技術

misc_type: others


en: 膵管内発育を主とし特異な形態を呈した膵腺房細胞癌の1例

ja: 膵管内発育を主とし特異な形態を呈した膵腺房細胞癌の1例

en: 消化器画像

ja: 消化器画像


en: 嚢胞変性により特異な形態を呈した胃GISTの1例

ja: 嚢胞変性により特異な形態を呈した胃GISTの1例

en: 胃と腸

ja: 胃と腸


en: Jejunal extramedullary plasmacytoma

ja: Jejunal extramedullary plasmacytoma

en: GASTROINTESTINAL ENDOSCOPY

ja: GASTROINTESTINAL ENDOSCOPY