type: misc

label: url

en: 腎臓病に対するビタミンAの影響

ja: 腎臓病に対するビタミンAの影響

en: Vitamins

ja: ビタミン


en: 慢性腎臓病CKDとたんぱく質栄養

ja: 慢性腎臓病CKDとたんぱく質栄養

en: 食肉の多様性と未来 国産食肉の安全・安心2021

ja: 食肉の多様性と未来 国産食肉の安全・安心2021


en: ビタミンDと加齢

ja: ビタミンDと加齢

en: アグリバイオ

ja: アグリバイオ


en: ビタミン・微量元素不足が生じやすい状況と補充で期待される効果

ja: ビタミン・微量元素不足が生じやすい状況と補充で期待される効果

en: Medical Practice

ja: Medical Practice


en: 児童生徒の食と健康(2)児童生徒の成長と骨の健康維持

ja: 児童生徒の食と健康(2)児童生徒の成長と骨の健康維持

en: 栄養教諭 : 食育読本

ja: 栄養教諭 : 食育読本


en: Disorder of phosphorus metabolism and dietary management in chronic kidney disease

ja: 教授就任記念講演 慢性腎臓病におけるリン代謝異常と食事管理

en: Chronic kidney disease is a common disease impacting more than 13 million individuals in Japan. CKD causes various complications including cardiovascular disease, infectious disease, and metabolic bone disease. Systemic mineral disorder caused by CKD increases cardiovascular disease and mortality risks as well as metabolic bone disease. Now, it is known as CKD-mineral and bone disease(CKD-MBD)characterized by blood biochemical abnormalities, bone abnormalities and extraskeletal calcification. Management of CKD-MBD is important to decrease cardiovascular disease and mortality risks. Hyperphosphatemia is a primary cause of CKD-MBD. Not only correction of hyperphosphatemia but also decrease in dietary phosphorus load is a key strategy for management of CKD-MBD. Here we will provide an overview of disorder of phosphorus metabolism and dietary management in CKD patients.

en: Shikoku Acta Medica

ja: 四国医学雑誌


en: Management of phosphorus load in CKD patients.

en: Disturbances in mineral and bone metabolism play a critical role in the pathogenesis of cardiovascular complications in patients with chronic kidney disease (CKD). The term "renal osteodystrophy" has recently been replaced with "CKD-mineral and bone disorder (CKD-MBD)", which includes vascular calcification as well as bone abnormalities. In Japan, proportions of the aged and long-term dialysis patients are increasing which makes management of vascular calcification and parathyroid function increasingly more important. There are three main strategies to manage phosphate load: phosphorus dietary restriction, administration of phosphate binder and to ensure in the CKD 5D setting, an adequate dialysis.

en: Clinical and Experimental Nephrology

ja: Clinical and Experimental Nephrology

number: No.Suppl 1


en: Assessment of trace mineral and vitamin deficiency

ja: 微量元素・ビタミン不足の評価 (特集 栄養障害患者の評価)

en: Endocrinology, Diabetology & Metabolism

ja: 内分泌·糖尿病·代謝内科


en: ビタミン・ミネラルと糖尿病

ja: ビタミン・ミネラルと糖尿病

en: ホルモンと臨床

ja: ホルモンと臨床


en: 生活習慣病の要:栄養教育と実践

ja: 生活習慣病の要:栄養教育と実践

en: Clinical Calcium

ja: Clinical Calcium


en: 生活習慣病予防のための生活習慣

ja: 生活習慣病予防のための生活習慣

en: めんたるへるす

ja: めんたるへるす


en: Phosphate as a novel signal in the intracellular signal transduction

ja: 新規シグナルとしてのリン酸(<特集>ビタミンB研究委員会平成26年度シンポジウム「ビタミン・バイオファクターの生理機能に関する最新の話題」)

en: The phosphate (Pi)-mediated signal transduction pathways in renal proximal tubular cells and endothelial cells were examined, because Pi depletion and overloading are known to influence gene expression and cellular function. In renal proximal tubular calls (LLC-PK1), Pi depletion resulted in increases in intracellular inositol triphosphate (IP3) and calcium ion (Ca^<2+>) levels, the latter of which may be associated with the maintenance of Pi homeostasis. On the other hand, exposing bovine aortic endothelial cells to excessive Pi load increased production of reactive oxygen species, which depended on phosphorus influx via sodium-dependent phosphate transporters, and decreased nitric oxide production via inhibitory phosphorylation of endothelial nitric oxide synthase. Pi loading in rat aortic rings inhibited endothelium-dependent vasodilation. A high dietary Pi load in human subjects increased serum Pi level at 2 h and significantly decreased flow-mediated dilation. Thus, it was found that the function of endothelial cells was damaged by the high dietary Pi loading. Taken together, these findings suggest that the changes in serum Pi level are associated with human health by affecting the intracellular Pi signal transduction pathway.


en: 新規シグナルとしてのリン酸

ja: 新規シグナルとしてのリン酸

en: Vitamins


en: A novel function of phosphorus

ja: リンの有する新しい作用

en: Phosphorus is an essential nutrient for bone formation by forming hydroxyapatite with calcium. Simultaneously, phosphorus is also a component of high energy bond of ATP, nucleic acids, and phospholipids. Recent studies have demonstrated that excess or lack of dietary phosphorus intake may cause vascular dysfunction, cardiac hypertrophy, and impaired glucose tolerance. Here, we introduce recent findings about the effects of high or low dietary phosphorus intake on several organs except for bone.


en: 食餌性リンによる血管障害

ja: 食餌性リンによる血管障害

en: Journal of Japanese Society for Dialysis Therapy

ja: 日本透析医学会雑誌


ja: 小児疾患および成人疾患からみたビタミンD栄養学

en: Nutritional science of vitamin D in pediatric and adult diseases was summarized. Vitamin D-dependency type II is a rare disease caused by a disorder of the human vitamin D receptor (VDR). Except for the alopecia, severe rickets and other biochemical abnormalities of 6 patients were reversed by treatment with 3 g/kg/d of 1-hydroxyvitamin D_3. A polymorphism at the translation initiation codon of the human VDR gene also affects the bone mineral density (BMD) in Japanese. Attention to phosphorus intake is important because both phosphorus deficiency and overloading impair bone health and quality of life (QOL). Elevation of extracellular phosphorus level causes endothelial dysfunction and medial calcification, which are closely associated with the development of cardiovascular disease (CVD). A dietary approach to limit phosphorus intake is particularly important to prevent bone impairment and CVD in patients with chronic kidney disease (CKD). Increased serum fibroblast growth factor 23 (FGF23)level is an early finding of abnormal mineral metabolism in CKD which causes secondary hyperparathyroidism and resistance of the parathyroid gland to the action of FGF23. In order to improve bone health and QOL in the general population, it should be important that attention to phosphorous intake from processed foods containing phosphorus additive is paied.


en: 小児疾患および成人からみたビタミンD栄養学

ja: 小児疾患および成人からみたビタミンD栄養学


en: 「日本食」の食卓を科学的に評価する③ニュートリゲノミクスを用いた日本食の評価

ja: 「日本食」の食卓を科学的に評価する③ニュートリゲノミクスを用いた日本食の評価

en: PRACTICE

ja: PRACTICE


en: 「日本食」の食卓を科学的に評価する②日本食を用いたボリュメトリクス(Volumetrics):エネルギー密度(ED)に注目した低エネルギーでも満腹度・満足度の高い食事


en: 「日本食」の食卓を科学的に評価する①食後高血糖を抑制する食事

ja: 「日本食」の食卓を科学的に評価する①食後高血糖を抑制する食事


en: Polymorphisms of vitamin D binding protein gene and diseases

ja: ビタミンD結合タンパク質の遺伝子多型と疾患(<特集>「ビタミンと遺伝子多型」-ビタミンD-)

en: Vitamin D binding protein (DBP), which is also known as a group-specific component (GC)-globulin, is a major plasma carrier protein for vitamin D and its metabolites. DBP is also known as an actin scavenger and a precursor of GC protein-derived macrophage activating factor (GC-MAF). This multifunction protein plays a role in the determination of serum 25-hydroxyvitamin D levels and regulation of the immune system. Therefore, genetic variants of DBP may affect risks of various diseases related with vitamin D levels and the immune system. Until now, various protein and genetic polymorphisms of DBP have been identified. Especially, Gc1S, Gc1F and Gc2 are well-known polymorphisms characterized by isoelectrophoresis, which are derived from two missense variants of DBP gene encoding D432E (rs7041) and T436K (rs4588). In this review, we discuss some relationships between DBP genotypes and common disease risk including osteoporosis, cancer and diabetes.


en: 慢性腎不全時のリン制限食を用いた栄養療法は，腎性貧血の発症進展を予防する

ja: 慢性腎不全時のリン制限食を用いた栄養療法は，腎性貧血の発症進展を予防する

en: Shikoku Acta Medica


en: リンの栄養学 健康と疾患(解説)

ja: リンの栄養学 健康と疾患(解説)

en: 香川県小児科医会会誌

ja: 香川県小児科医会会誌


en: Depression and nutrition

ja: うつ病と栄養 (特集 メンタルヘルスと栄養)

en: Severe and prolonged stress exposure impairs homeostatic mechanisms, particularly associatedwith the onset of depressive illness. Brain food is aimed at preventing as well as treating a growingnumber of depression. An increase in brain tryptophan levels on the order of that produced byeating a carbohydrate-rich/protein-poor meal causes parallel increases in the amounts of serotoninreleased into synapses. Dietary antioxidants present in fruits and vegetables may also improvemood. Furthermore, lifestyle of breakfast, lunch and dinner with family or friends is a very importantfactor to reduce depression.


en: 栄養素輸送システムと食品機能

ja: 栄養素輸送システムと食品機能

en: 消化と吸収

ja: 消化と吸収


en: ビタミンと生活習慣病(特集:生活習慣病の栄養管理)

ja: ビタミンと生活習慣病(特集:生活習慣病の栄養管理)

en: 成人病と生活習慣病

ja: 成人病と生活習慣病


en: Vitamin D and phosphate metabolism --- relationship with aging-regulating gene

ja: ビタミンDとリン代謝 --- 加齢遺伝子とのかかわり

en: CLINICAL CALCIUM

ja: CLINICAL CALCIUM


en: ビタミンDレセプター遺伝子多型と骨代謝

ja: ビタミンDレセプター遺伝子多型と骨代謝

en: 臨床栄養

ja: 臨床栄養


en: 特集「透析患者の栄養評価における新理論と新技術」Ⅰ総論:最近の栄養評価における理論と技術およびその問題点

en: 臨牀透析

ja: 臨牀透析


en: 特集 - エビデンスからみた機能性食品の現状 2. 耐糖能改善食品(1)食物繊維

en: 栄養評価と治療

ja: 栄養評価と治療


en: 生体におけるリンの役割と制御

ja: 生体におけるリンの役割と制御

en: 腎不全とリン

ja: 腎不全とリン


en: The regulation and function of phosphate in the human body

en: Inorganic phosphate (Pi) is required for cellular function and skeletal mineralization. Serum Pi level is maintained within a narrow range through a complex interplay between intestinal absorption, exchange with intracellular and bone storage pools, and renal tubular reabsorption. Pi is abundant in the diet, and intestinal absorption of Pi is efficient and minimally regulated. The kidney is a major regulator of Pi homeostasis and can increase or decrease its Pi reabsorptive capacity to accommodate Pi need. The crucial regulated step in Pi homeostasis is the transport of Pi across the renal proximal tubule. Type II sodium-dependent phosphate (Na/Pi) cotransporter (NPT2) is the major molecule in the renal proximal tubule and is regulated by hormones and nonhormonal factors. Recent studies of inherited and acquired hypophosphatemia which exhibit similar biochemical and clinical features, have led to the identification of novel genes, phosphate regulating gene with homologies to endopeptidases on the X chromosome (PHEX) and fibroblast growth factor-23 (FGF-23), that play a role in the regulation of Pi homeostasis. The PHEX gene encodes an endopeptidase, predominantly expressed in bone and teeth but not in kidney. FGF-23 may be a substrate of this endopeptidase and inhibit renal Pi reabsorption. In a survey in the United States and in Japan, the amount of phosphorus from food is gradually increasing. It is thought that excess amounts of phosphorus intake for long periods are a strong factor in bone impairment and ageing. The restriction of phosphorus intake seems to be important under low calcium intake to keep QOL on high level.

en: BioFactors

ja: BioFactors


en: 分子栄養学からみた糖尿病の予防と治療

ja: 分子栄養学からみた糖尿病の予防と治療


en: 肝疾患における低栄養の病態と治療

ja: 肝疾患における低栄養の病態と治療

en: KAN TAN SUI

ja: 肝·胆·膵


en: 重症心身障害児の至適投与熱量と栄養基質

ja: 重症心身障害児の至適投与熱量と栄養基質

en: JJPEN輸液栄養

ja: JJPEN輸液栄養


en: ミネラルの生体での代謝と吸収

ja: ミネラルの生体での代謝と吸収

en: FOOD Style 21

ja: FOOD Style 21


en: 肝硬変の栄養療法-夜食による早朝空腹時のエネルギー代謝改善効果-

ja: 肝硬変の栄養療法-夜食による早朝空腹時のエネルギー代謝改善効果-

en: 日本病態栄養学会誌

ja: 日本病態栄養学会誌


en: カルシウム・リン酸輸送とカベオラ

ja: カルシウム・リン酸輸送とカベオラ

en: 腎と骨代謝

ja: 腎と骨代謝


en: 炎症性腸疾患の栄養アセスメント

ja: 炎症性腸疾患の栄養アセスメント


en: Renal handling of phosphate

ja: Renal handling of phosphate

en: Calcium In Internal Medicine

ja: Calcium In Internal Medicine


en: Evaluation of anti-stress nutrients in the endothelial cells with fluorescence indicator

en: Oxidative stress has emerged as an important pathogenic factor in the development of long-term complications, such as hypertension, atherosclerosis, nephropathy, and cancer. Taking many antioxidants from natural food may be effective to prevent us from those diseases. We have attempted to evaluate the effect of improvement by dietary antioxidants on the endothelial dysfunction induced by hyperglycemia. Fluorescence indicators for reactive oxygen species and nitric oxide were employed to the evaluation. The combination of those fluorescence indicators could be powerful tool to evaluate the effect of anti-stress nutrients on both oxidative stress and endothelial dysfunction.

en: The Journal of Medical Investigation : JMI

misc_type: others


en: Control of oxidative stress and metabolic homeostasis by the suppression of postprandial hyperglycemia

en: Repeated mental stress may lead to chronic alterations in cortisol and catecholamine concentrations and to insulin resistance. Furthermore, chronically elevated cortisol concentrations may favour the development of abdominal obesity and of the metabolic syndrome. Oxidative stress impairs glucose uptake in muscle and fat and correlates with BMI. Obese subjects with type 2 diabetes, especially soon after the onset of diabetes, usually exhibit postprandial hyperglycemia with delayed hyperinsulinemia. It is recognized that insulin resistance causes postprandial hyperglycemia; however, it is also possible that impairment of early insulin secretion in response to an oral glucose load is the reason why postprandial hyperglycemia occurs. Since even modest increases in postprandial glucose values can be a risk factor for cardiovascular disease. Therefore, the effects of palatinose based functional food which reduces postprandial hyperglycemia and hyperinsulinemia were investigated in rats. This novel food definitely reduced visceral fat accumulation and improved insulin sensitivity. Therefore, it is suggested that functional food which suppresses postprandial glucose level is beneficial for both stress and metabolic controls.

ja: The Journal of Medical Investigation : JMI

volume: Vol.52 Suppl