Characteristics of a Transactive Phenomenon in Relationships among Older Adults with Dementia, Nurses as Intermediaries, and Communication Robot


Relationship between sleep-wake rhythms and autonomic nerve activities of elementary school children through Actigraphy

小学校高学年児童の睡眠・覚醒リズムと自律神経活動の関係

The purpose of this study was to clarify the relationship between sleep-wake rhythms and autonomic nerve activities using actigraphy and heart rate variability(HRV)analysis. Subjects were comprised of six children who were in the fourth to sixth grade levels of elementary school(four boys and two girls). The study was conducted between January and December 2015. The data collection procedure was performed following the Private Information Protection Law, with approval from Tokushima University Hospital Ethics Board(approval number 2021). These subjects were evaluated in an Attentive-Care-Needed stress state based on the PSI(Public Health Research Foundation Type Stress Inventory)and PSQI-J(Pittsburgh Sleep Quality Index, Japanese Version). In analyzing their sleep-wake rhythms, autonomic nervous activities were determined using an actigraph and HRV through RR interval sequence electrocardiography. The results of actigraph data of sleep efficiency in Subject Number 6 was low(76.47%). Regardless, the subject experienced subjective sleep satisfaction. However, Subject Number 2, insisted that she could not easily wake up in the morning because of being sleepy. Low Frequency(LF)/High Frequency(HF)data indicated sympathetic nervous activity showing that all subjects had significantlyhigher LF/HF value during wakefulness than when asleep. HF data indicated parasympatheticactivity of five out of the six children showing significantly higher value during sleep than when awake. Subject number 3 expressed that he was sleepy and could not get up in the morning,and also had trouble going to and maintaining sleep. However, this subject's results of the PSQI-Jindicated that he had no problem expressing subjective sleep satisfaction. Furthermore, in the actigraph and HRV analysis, findings showed that subjects had good sleeping patterns. These findings strongly signify the importance of determining the sleep-wake rhythms of school children based on data from subjective and physiological evaluation methods.


Characteristic Autonomic Nervous Activity of Institutionalized Elders with Dementia


The Effect of Intentional Communication, Recreation, and Rehabilitation on the Autonomic Nervous Activity of Elderly Persons with Dementia : A Case Study


Electrocardiographic and chronobiological features of paroxysmal AV block recorded by ambulatory electrocardiography.

The goal of this study was to investigate the electrocardiographic and chronobio-logical features of paroxysmal atrioventricular (AV) block (PAVB) using data from ambulatory electrocardiography (AECG). The study population consisted of five men and six women aged from 47 to 82 years of age. Main presenting symptoms were pre-syncope in five patients (45.5%) and syncope in three patients (27.3%). Organic cardiovascular diseases were seen in eight patients (72.7%), and AV conduction disturbances were seen in six patients (54.5%), such as right bundle branch block, first to second degree AV block on standard 12-lead electrocardiography. Incidence of PAVB events were 1-329 (37.9 ± 98.0) episodes/patient/day, and the maximum pause during Holter recordings was 3.3-12.4 (6.39 ± 3.09) seconds. This maximum pause caused by intrinsic AV block was longer than that of vagally mediated AV block (8.4 ± 3.2 sec vs 4.7 ± 1.0 sec, p<0.05). In chronobiological analysis, episodes of PAVB exhibited a circadian rhythm characterized by a peak between 2:00 am and 4:00 am and a trough between 0:00 pm and 2:00 pm. AECG is a useful tool to detect the maximum pause occurring during sleep and provides critical data necessary to prevent the sudden cardiac death caused by PAVB.

The Journal of Medical Investigation : JMI


Clinical training stress and autonomic nervous function in female medical technology students: analysis of heart rate variability and 1/fluctuation

To evaluate the level of stress induced by clinical training, ambulatory electrocardiograms from 12 healthy female medical technology students were recorded and the spectral components of heart rate variability (HRV) were analyzed as an index of autonomic nervous function. The HF power reflecting parasympathetic tone was significantly decreased at awakening, compared with that before clinical training (p<0.01). The LF/HF ratio reflecting sympathetic activity also significantly increased during, compared with before clinical training (p<0.01). The slope of the spectral density also changed before and during the clinical training from -1.20+/-0.04 to -1.09+/-0.03 (p<0.05). The 1/f fluctuation of HRV appeared comfortable, and tension was apparently adequate while undergoing clinical training. None of these HRV indices statistically changed while asleep. Thus, the students perceived the stress as a comfortable level of tension and analyzing spectral components and 1/f fluctuation of HRV might be a useful method for evaluating study stress.


Influence of an artificial pleural effusion technique on cardio-pulmonary function and autonomic activity

Percutaneous treatment of hepatocellular carcinoma (HCC) located directly under the diaphragm is problematic because ultrasonic imaging is difficult, and the lung may be injured during the procedure. It has been reported that an infusion of 5% glucose solution into the thoracic cavity enables percutaneous treatment in such cases. However, the safety aspects of this have not been investigated. In this study, variations in heart rate and changes in circulatory and respiratory dynamics were examined during the infusion of artificial pleural effusion directly under the diaphragm in patients with HCC. The subjects were 13 patients with an HCC directly under the diaphragm. About 500 ml of a 5% glucose solution was infused into the thoracic cavity, and mean blood pressure, heart rate, and oxygen saturation were measured. Holter electrocardiography was simultaneously recorded to evaluate autonomic nerve function. To analyze variations in heart rate, the low-frequency waves (LF: 0.04-0.15 Hz), high-frequency waves (HF: 0.15-0.40 Hz, an index of parasympathetic nerve activity), and the LF/HF ratio (index of sympathetic nerve activity) were examined. The above parameters were measured before, during (when infusion of the half the planned volume was complete), and after infusion were compared. No significant changes in the mean blood pressure or heart rate were found. Oxygen saturation was significantly decreased during and after the infusion. The HF value was slightly higher after infusion and the LF value was significantly increased during infusion. The LF/HF ratio was significantly increased during infusion, and this increase persisted after infusion. The infusion of artificial pleural effusion had no effect on circulatory dynamics, but transiently affected respiratory functions. It was also revealed that infusion stimulated the parasympathetic nerves.


An Investigation on the Affinity between the Questions in the National Examination for Medical Technologist and Educated Contents in the Course of Laboratory Medicine : Nine Years History of the Committee Groping Appropriate Questions --- 9年間の問題基準検討委員会のあゆみを振り返って

臨床検査技師国家試験問題と教育内容との整合性についての検討 --- 9年間の問題基準検討委員会のあゆみを振り返って

In order to evaluate the each question in the National Examination for Medical Technologist by comparison with the educated level in the course of laboratory medicine and the practical level of medical technologists, the investigation has been carried out by our committee established in the National University Association for Education of Laboratory Medicine during 9 years since 1997. The committee has asked each school of the 20 members of the Association to pick up good and/or inappropriate questions with the reasons why they are classified as good or improper ones. Some questions were considered as good ones by a large number of schools, while the others were considered improper. The reasons for the judgment have been sometimes very controversial and opinions uncommonly run counter to each other. It is suggested that a good question may become to be improper when the questionnaire is carelessly arranged even if the concept of the question is initially well considered. It is presumed that the annual reports of our committee may have played a role to gain common recognition that the numbers of the inappropriate questions have been decreasing in the recent National Examination for Medical Technologist.

The Official Journal of Japanese Society of Laboratory Medicine


The relationship between autonomic nervous activity and physical activity in children

There have been few studies that have reported on heart rate variability and the development of autonomic nervous function in children. This study investigated the relationship between heart rate variabilities at night and physical activity in children. The study subjects were 29 children, including 17 boys and 12 girls. The daily activity product and heart rate variabilities during sleep at night (00.00-05.00 hours) were measured and several aspects of these parameters were analyzed. In one child (an 8-year-old girl), heart rate variability and the physical activity product were measured for 12 days. There was a negative correlation between the mean R-R interval and the duration (min) of heavy exercise per day (r = -0.39, P < 0.05). In the 8-year-old girl, from whom data was obtained for 12 days, the duration of heavy exercise per day was negatively correlated with the mean R-R interval (r = -0.63, P < 0.05), the number of changes in successive R-R intervals greater than 50 msec (RR50) (r = -0.74, P < 0.01), and the high frequency (HF) component (r = -0.66, P < 0.05). Furthermore, the daily number of steps was negatively correlated with the mean R-R interval (r = -0.66, P < 0.05), RR50 (r = -0.71, P < 0.05) and the HF component (r = -0.66, P < 0.05). There was a negative correlation between the amounts of energy consumption and the mean R-R interval (r = -0.69, P < 0.05). There was a negative correlation between the amounts of energy consumption and RR50 (r = -0.76, P < 0.01). Moreover, there was also a negative correlation between the amount of energy consumption and the HF component (r = -0.71, P < 0.05). These findings suggested that physical activities increase heart rate during sleep, but reduce parasympathetic nervous activity at night. Because both the HF component and RR50 reduce with growth, the exercise-related inhibition of parasympathetic nervous activity may be a developmental stimulus to reach a balanced autonomic nervous pattern in adults.


Impairment of gastrointestinal motility by nitrate administration: evaluation based on electrogastrographic changes and autonomic nerve activity

Nitrates decrease the tone of the lower oesophageal sphincter, and may thus induce gastro-oesophageal reflux. In the present study, we evaluated electrogastrographic changes and heart-rate variability before and after the administration of nitrates. In 15 patients with chest pain treated with nitrates, electrocardiography and percutaneous electrogastrography were performed before and after administration of nitrates. Autonomic nervous system function was evaluated by spectral analysis of heart-rate variability and serial changes in low frequency and high frequency power, and the low frequency/high frequency ratio were compared. Electrogastrograms were analysed by obtaining peak power amplitudes and their dominant frequencies. After the administration of nitrates (isosorbide dinitrate), high frequency power, an index of parasympathetic nervous activity, was significantly decreased, whereas the low frequency/high frequency ratio, an index of sympathetic nervous activity, was significantly increased. The mean peak amplitude of the electrogastrogram significantly increased postprandially both before and after treatment. After isosorbide dinitrate treatment, however, mean peak amplitudes after a meal were significantly lower than those obtained before treatment. The mean dominant frequency of the electrogastrogram did not vary before and after treatment. The present study suggests that nitrates inhibit gastrointestinal motility by decreasing autonomic nervous activity.


Influence of sleep apnea on autonomic nervous activity and QT dispersion in patients with essential hypertension and old myocardial infarction

Sleep apnea syndrome (SAS) is an important cardiovascular risk factor in patients with hypertension or myocardial infarction (MI). We evaluated the influence of SAS on autonomic nervous activity and QT dispersion in patients with hypertension or coronary artery disease with old MI. A portable sleep polygraph was attached to 30 healthy volunteers (N group), 30 patients with essential hypertension (HT group), and 30 patients with old myocardial infarction (MI group) to serially record oronasal respiration, tracheal sound, thoracic respiratory movement, and percutaneous arterial oxygen saturation. In addition, a digital Holter ECG was used to examine heart rate variability during nighttime sleep. Heart rate variability was analyzed by obtaining low-frequency (LF) power, high-frequency (HF) power, the LF/HF ratio, and very low-frequency (VLF) power. Dispersion of QT intervals was obtained by CM5 and CM1 leads. VLF and LF powers were significantly higher in the HT-SAS group (hypertensive patients with SAS) than the N and HT-NSAS groups (hypertensive patients without SAS). The HF power was significantly lower in the HT-NSAS group than the N group, but the decrease in HF power in hypertension was not observed in the HT-SAS group. The LF/HF ratio was significantly higher in the HT-NSAS group than the N group, and this value was further increased in the HT-NSAS group. Percutaneous arterial oxygen saturation was decreased, and QT dispersion was significantly increased in the MI group during sleep apnea episodes. More severe autonomic nervous dysfunction and increased QTc dispersion were observed in hypertensive patients with SAS during episodes of apneas and hypopneas compared to those without SAS. These findings suggest that SAS may be associated with the future development of cardiac events.


胃X線検査時における体位変換時の自立神経活動の変動 --- 心拍変動解析による検討

日本消化器集団検診学会雑誌

日本消化器集団検診学会雑誌


Effects of Epalrestat, an Aldose Reductase Inhibitor, on Diabetic Neuropathy and Gastroparesis

Diabetic patients with severe autonomic nervous disorder show delayed gastric emptying accompanied by diabetic gastroparesis, which decreases the electric activity of the stomach associated with gastric motility. It is reported that epalrestat, an aldose reductase inhibitor, is useful for treating diabetic neuropathy. Therefore, we evaluated whether this drug improves the decreased gastric motility in diabetic patients. The present study evaluated the electrogastrograms (EGG) and autonomic nervous activity in 15 healthy volunteers (N group), and in 15 diabetic patients before and after the administration of epalrestat (DM group). Autonomic nervous activity was evaluated by spectral analysis of heart rate variability. The EGGs were recorded before and after oral administration of epalrestat (3 months or more) in the DM group. The dominant frequency of EGG was 3 cycles/min (cpm) in the N group. However, these 3 cpm waves disappeared with bradygastria, and postprandial increases in the peak powers of EGG were not observed in the DM group. Both the amplitude of 3 cpm waves and the postprandial peak powers were significantly increased after the administration of epalrestat. The parameters of autonomic nervous activities (LF power, HF power, and the LF/HF ratio) were significantly lower in the DM group before the administration of epalrestat than in the N group. However, these parameters were improved after the administration of epalrestat. Since gastroparesis is a form of diabetic dysautonomia, complication by gastroparesis may influence blood sugar control and the absorbance of oral antidiabetics. Epalrestat significantly increased the amplitude of 3 cpm waves on EGG and improved the spectral analytical parameters of heart rate variability. These findings suggest that epalrestat is useful for the treatment of diabetic gastroparesis.


Effects of Benidipine Hydrochloride on Autonomic Nervous Activity in Hypertensive Patients with High- and Low-salt Diets

The effects of benidipine hydrochloride (CAS 91559-74-5, Coniel) on autonomic nervous activity in hypertensive patients with high- and low-salt diets were investigated. Six patients having a urinary sodium excretion of 80 mEq/day or less (low salt group) and 6 patients having a urinary sodium excretion of 200 mEq/day or more (high salt group) were orally given benidipine hydrochloride (4 mg). Before and four weeks after the treatment with benidipine, 24-h circadian variation in blood pressure and 24-h Holter electrocardiogram (ECG) were recorded. The low frequency power spectrum of heart rate (LF power; 0.04-0.15 Hz), high frequency power spectrum of heart rate (HF power; 0.15-0.40 Hz), and the ratio of LF to HF (LF/HF) were calculated, and these parameters were averaged every hour in every subject. HF power was significantly lower and LF/HF ratio was significantly higher in the high-salt group than in the low-salt group before the treatment. However, the benidipine treatment significantly increased the HF power in both groups, particularly in the high-salt group, and significantly decreased the LF/HF ratio in both groups. Moreover, there was no significant difference in the antihypertensive effect of benidipine between the high- and low-salt intake groups. These results suggest that benidipine favourably influences blood pressure and autonomic nervous activity in hypertensive patients with a high-salt intake. It is concluded that benidipine may be useful for improving the development of salt-induced hypertension and its accompanying haemodynamic responses.


発作性心房細動の発生様式に関する検討 ー心房性期外収縮と自律神経機能の関与

発作性心房細動の発生様式に関する検討 ー心房性期外収縮と自律神経機能の関与


Changes in autonomic nervous activity during endoscopic retrograde cholangiopancreatography:a possible factor in cardiac complications.

The changes of autonomic nervous activity during endoscopic retrograde cholangiopancreatography (ERCP) are closely related to the development of cardiovascular complications, such as arrhythmias and acute coronary syndrome. In the present study, the correlation between changes in hemodynamics and autonomic nervous activity during ERCP procedures was evaluated by analyzing heart rate variability and blood catecholamine levels. Twenty-three patients who underwent ERCP (ERCP group) and 15 control subjects who were only premedicated (C group) were studied. Ambulant ECG, blood pressure, arterial oxygen saturation, and blood level of catecholamine were measured. Autonomic nervous function was assessed by analyzing the spectral analysis and 1/f fluctuation. The low frequency power (LF power; 0.04-0.15 Hz), high frequency power (HF power; 0.15-0.40 Hz, indicator of parasymapathetic tone), the ratio of LF power to HF power (LF/HF ratio, indicator of sympathetic tone), and 1/f fluctuation (indicator of pleasant mood) were calculated. Blood pressure and heart rate were increased and arterial oxygen saturation was decreased in the ERCP group during the endoscopic procedure. Changes in the parameters of autonomic nervous function (LF power, HF power, LF/HF ratio, and 1/f fluctuation) were significantly greater in the ERCP group than in the C group, especially during cholangiography. Moreover, blood levels of catecholamines were significantly increased during the ERCP procedure. In the C group, however, blood levels of catecholamines did not significantly change except directly after premedication. Autonomic nervous activity varied greatly during cholangiography, demonstrating that ERCP has more than a little influence on the cardiovascular system. The results of the present study indicated that attention should be focused on changes in hemodynamics in patients with cardiovascular complications by monitoring the aforementioned hemodynamic parameters during ERCP.

Journal of Gastroenterology and Hepatology


Changes in Hemodynamics and Autonomic Nervous Activity in Patients Undergoing Laparoscopic Cholecystectomy:Differences Between the Pneumo-Peritoneum and Abdominal Wall-Lifting Method

Intraoperative changes in circulatory hemodynamics and autonomic nervous activity were evaluated in 33 patients with cholelithiasis who underwent laparoscopic cholecystectomy. Of these patients, 18 were treated using a pneumoperitoneum (group G) and 15 using the abdominal wall-lifting method (group WL). Their ECG, blood pressure, arterial oxygen saturation, and expiratory carbon dioxide partial pressure were monitored. Autonomic nervous function was evaluated by spectral analysis of the heart rate. Mean blood pressure increased significantly in group G during surgery, but did not vary in group WL during any stage of surgery. The high-frequency (HF) power, an index of parasympathetic activity, decreased significantly in group G after pneumoperitoneum. However, the HF power did not decrease significantly in group WL. The LF/HF ratio, an index of sympathetic activity, increased significantly in group G after pneumoperitoneum, but did not vary in group WL. In addition, the incidence of ventricular or supraventricular arrhythmias and the severity of the arrhythmias as determined by Lown's classification were higher in group G than in group WL. These findings suggest that intraoperative changes in autonomic nervous activity, due to increased intra-abdominal pressure, were smaller in patients undergoing laparoscopic cholecystectomy using the abdominal wall-lifting method than in those undergoing laparoscopic cholecystectomy using pneumoperitoneum. The results also demonstrated that hemodynamic changes were smaller in patients undergoing the abdominal wall-lifting method than in those undergoing pneumoperitoneum. It was concluded that hemodynamics should be carefully monitored during pneumoperitoneum, and that the abdominal wall-lifting approach in laparoscopic cholecystectomy is a method worthy of consideration for elderly patients or those with cardiopulmonary complications.


トータル·ヘルス·プロモーション·プランによるインスリン抵抗性と最大酸素摂取量への効果


Detection of myocardial damage caused by hepatitis C virus using signal averaged electrocardiogram and I-BMIPP myocardial scintigraphy


Relationship among gastric motility,autonomic activity,and portal hemodynamics in patients with liver cirrhosis

We examined the effects of the autonomic nervous function and the volume of portal blood flow to clarify the mechanism of the abnormal gastric motility in patients with liver cirrhosis. Heart rate variability, electrogastrogram (EGG), and volume of portal blood flow were measured before and after a meal in 27 patients with liver cirrhosis (LC group) and in 20 normal subjects (N group). Autonomic nervous function was evaluated by using spectral analysis of heart rate variability. We used the cine phase-contrast (PC) method, using magnetic resonance imaging (MRI) to measure the portal flow, while the peak frequency and spectral power of the EGG were measured at pre- and postprandial change. The ratio of low frequency power to high frequency power (LF/HF) was significantly higher, and the HF power was significantly lower in the LC group than in the N group both before and after a meal. In both groups, the electrogastrographic peak power ratio before and after a meal showed a positive correlation with the HF ratio, and an inverse correlation with the LF/HF ratio. In addition, portal blood flow volume was significantly decreased in the LC group than in the N group. However, the increased rate of portal blood flow after a meal correlated positively with the increased rate of electrogastrographic peak power. Moreover, gastric motility was positively correlated with esophageal varices and coma scale with the use of multivariate analysis. Parasympathetic hypofunction, sympathetic hyperfunction and portal hemodynamics were closely related with gastric motility in cirrhotic patients. In addition, gastric motility was decreased, at least in part, by the ingestion of food in cirrhotic patients because of abnormalities in autonomic functions and portal blood flow following a meal.


摂食による冠動脈血流速度の変化，胃電図および冠動脈シネMRAを用いた検討

摂食による冠動脈血流速度の変化，胃電図および冠動脈シネMRAを用いた検討


心房細動治療に関するアンケート調査 ‐徳島県と全国の比較‐

心房細動治療に関するアンケート調査 ‐徳島県と全国の比較‐


Autonomic nervous function in patients with peptic ulcer studied by spectral analysis of the heart rate variability

This study is intended to clarify the relationship between occurrence of peptic ulcer disease and dysfunction of the autonomic nervous system. We studied heart rate variability and assessed the circadian rhythm of autonomic nervous function in 20 patients with peptic ulcer (PU group) and 20 age-matched healthy controls (N group) using 24-hour Holter monitoring. Moreover, the relationship between gastric juice secretion and autonomic activity was examined under intravenous injection of insulin or butylscopolamine in adult mongrel dogs. High frequency spectral (HF) power, an indicator of parasympathetic tone, was increased markedly at night in the PU group. Low frequency spectral (LF) power, an indicator of sympathetic tone modified by vagal tone, was higher during the day than at night in the N group, whereas this normal circadian rhythm of LF power disappeared in 11 cases (55%) in the PU group. In addition, the LF power was increased significantly at night (p<0.01) in the PU group. HF power and gastric juice secretion was increased by the administration of insulin. High sympatho-vagal tone at night may result in spasm of gastric arteries and excess secretion of gastric acid in the PU group. These results suggest that the nocturnal acceleration of LF, HF, and LF/HF is related to peptic ulcer diseases.


99mTc-MIBIによる運動負荷時冠血流増加率と冠動脈血流速波形との関連 --- -冠動脈MR coronary angiographyを用いた検討-


Stress and coping behavior in patients with diabetes mellitus.

Diabetes mellitus is a disease which must be controlled over the lifetime of a patient. We investigated the issues of stress and coping for diabetes mellitus which may influence self-management. In addition, we examined the association of these factors with blood glucose control, in order to review self-management instructions for diabetes mellitus. The study included 153 patients with diabetes mellitus. The patients were divided into two subgroups: good-control group, comprising patients with glycohemoglobin (HbA1c) values less than 7.0%; and poor-control group, comprising those with HbA1c values of 7.0% or more. All patients responded to a questionnaire regarding stress tolerance, Jalowiec and Power's coping scale and awareness of diabetes mellitus. Stress tolerance was not significantly different between the good-control and poor-control groups. No significant gender differences in coping score were evident for the good-control group. However, in the poor-control group, the coping score in men was significant higher than that in women. The problem-oriented coping score for men in the poor-control group was significantly higher than that for the good-control group (p < 0.01). In a comparison of awareness of diabetes mellitus, the proportion of patients who replied that they were rigidly following diabetes treatment was higher in the poor-control group than the good-control group. Patients with diabetes mellitus may have a knowledge of the disease and a strong will to resolve problems. This is especially true for male patients in that their will appeared to be stronger, but they may not have the resolve to establish appropriate behavior patterns. In the future, methods for evaluating self-management should be included in diabetes education.


ベット上における背面解放と非解放の座位姿勢時の自律神経活動の変化

ベット上における背面解放と非解放の座位姿勢時の自律神経活動の変化


Changes in autonomic nervous activity during colonoscopy using spectral analysis heart rate variability.


Is autonomic dysfunction a necessary condition for chronic peptic ulcer formation ?

The relationship between 1/f fluctuation of the heart rate variability and Helicobacter pylori infection was evaluated, in order to clarify whether autonomic nervous dysfunction is a necessary condition for chronic peptic ulcer formation. The subjects were 11 patients with recurrent chronic peptic ulcer and 20 age-matched normal subjects. Holter ECGs were recorded over 24 h, and the 1/f(-x) fluctuation of the heart rate was computed. The 1/f(-x) fluctuation of the heart rate is a novel index of autonomic function that has been shown to reflect a patient's pleasant mood. For 1/f(-x) fluctuation, the slope of the regression line (-x) was determined and cosine fitting of the absolute slope of the regression line over a 24-h period was performed. For the normal group, the absolute slope of the regression line during daytime and night-time were 0.53 +/- 0.16 and 1.05 +/- 0.18, respectively. For the peptic ulcer group, the corresponding values during daytime and night-time were 0.94 +/- 0.15 and 1.84 +/- 0.18, respectively. The mean value of the cosine curve was 0.76 +/- 0.23 in the normal group and 1.12 +/- 0.25 in the peptic ulcer group. Thus, these values were significantly higher for the latter group than for the former group (P<0.05). No statistically significant difference in H. pylori infection between the two groups was observed. Autonomic nervous dysfunction as well as H. pylori infection appears to be a necessary condition for chronic peptic ulcer formation.


Evaluation of autonomic nervous function in patients with essential hypertension complicated with peptic ulcer


Age-related changes in the magnitude of ventricular depolarization vector : analyses by magnetocardiogram

The magnetocardiogram has the beneficial feature that permits the strength and location of the current dipole to be estimated. This study examines the issue of whether the magnitude of the heart current during depolarization phase was influenced by the age of healthy subjects. The magnetocardiograms were recorded by means of a second-derivative SQUID (superconducting quantum interference device) magnetometer (BT Corp, Model BMP, San Diego, CA) in 150 healthy subjects. The subjects were subgrouped into 5 age-based categories according to the age. The current dipole of the maximum QRS complex was determined from isofield contour maps during the ventricular depolarization phase, and no significant differences were observed in the magnitude in the current source for any age category. However, the amplitudes of the RV5 and SV1 + RV5 in the standard electrocardiogram were larger in 65 to 74-year-old women than other age groups, and the SV1 + RV5 was smaller for the 45 to 74-year-old men than for the men aged 25 to 44 years. These findings suggest that the age-associated changes in the QRS complex observed by the electrocardiogram are caused by increased electric resistance and not by the heart current itself. The results additionally suggest that no effects of aging were observed in the actual heart current of the heart during the depolarization phase.


高齢者における食事負荷による血圧変動の成因 ー心拍変動解析および胃電図における検討ー


心磁図法を用いた心臓異常所見の検出:心電図法で捉えられない心起電力を検出できるか

The Journal of Japan Biomagnetism and Bioelectromagnetics Society


高齢者における食後低血圧の成因 --- 自律神経活動および胃運動との関連性について

日本高齢者消化器医学会議会誌

日本高齢者消化器医学会議会誌


Evaluation of Cardiac Function in Myocardial Infarction Patients by ECG 99mTc-MIBI Gated SPECT Using a Three-dimensional Perfusion/Motion Map Procedure

Three-dimensional (3D) radionuclear myocardial imaging has improved the evaluation of left ventricular wall motion. However, there have been no studies evaluating left ventricular function using 3D-perfusion/motion map techniques. We hypothesized that the 3D-perfusion/motion map could accurately evaluate left ventricular wall motion even in patients with a history of myocardial infarction. Electrocardiogram (ECG)-gated single photon emission computed tomography (SPECT) using 99mTc-methoxy isobutyl isonitrile (MIBI) was performed in 20 patients with a history of myocardial infarction who underwent left ventriculography. Myocardial imaging data were collected during ECG-gated SPECT using a 3-headed gamma camera. Reconstructed 3D SPECT images were oriented to correspond to standard left ventriculography views (right anterior oblique and left anterior oblique projections), and the shortening fraction (SF) was calculated using the center line method. The SF and left ventricular ejection fraction from 3D SPECT images were compared with those determined by left ventriculography. There was a significant correlation between left ventriculography and the 3D-perfusion/motion map procedure in determining SF for all regions of the left ventricle except the anterobasal and posterior segments by using the Bland and Altman method. The 3D-perfusion/motion map procedure offers the advantage that the influences of contraction-related myocardial torsion and three-dimensional compression are minimized. In addition, this method facilitates evaluation of images from nonstandard projections. We conclude that this method may be useful for evaluating left ventricular function.


Two cases who died suddenly of dissecting aneurysm of aorta during monitoring with Holter ECG

ホルター心電図検査中に死亡した解離性大動脈瘤の2症例


QT dispersionの臨床的意義:心臓磁界を用いた左室肥大における検討

QT dispersionの臨床的意義:心臓磁界を用いた左室肥大における検討


Assessment of autonomic nervous activity during gastrointestinal endoscopy --- Analysis of blood pressure variability by tonometry

Journal of Gastroenterology and Hepatology


Brugada syndrome associated with an autonomic disorder


Dihydropridine系Ca拮抗薬の心臓交感神経機能への影響

Dihydropridine系Ca拮抗薬の心臓交感神経機能への影響


Effects of intravenous administration of L-arginine on autonomic nervous activities: Analysis of heart rate variability


Ischaemic electrocardiographic changes after massive blood transfusion : Findings based on myocardial scintigraphy using 99mTc-MIBI and 123I-MIBG

We performed myocardial scintigraphy on a patient with ischaemic electrocardiographic changes after massive blood transfusion. Although there was no defect by 99mTc-MIBI scintigraphy, 123I-MIBG scintigraphy was observed suggesting denervation after massive blood transfusion. Myocardial scintigraphy using 99mTc-MIBI or 123I-MIBG can be useful for the evaluation of myocardial dysfunction with reversible myocardial infarction.


Autonomic nervous system activity during infusion of L-arginine in patients with liver cirrhosis


Current micro-and Macroangiopathic Complication of Diabetic Patients by Primary Care Physicians on Multicenter-study

プライマリ·ケア医による糖尿病合併症の調査

日本プライマリ·ケア学会誌

日本プライマリ·ケア学会誌


心磁図法によるQTc dispersion:心筋梗塞による検討

心磁図法によるQTc dispersion:心筋梗塞による検討


Signal averaged electrocardiogram after exercise in patients with mitral valve prolapse

While late potentials are correlated with an increased incidence of ventricular tachycardia, they are not necessarily a good predictor of ventricular electrical instability in patients with mitral valve prolapse (MVP). Our objective was to determine whether the signal averaged electrocardiogram (SAECG) after exercise can discriminate groups with a higher frequency of ventricular arrhythmia from those without. The SAECG was recorded before and after treadmill exercise in 20 normal subjects (N group), 20 patients with MVP (MVP group) and 10 patients with old myocardial infarction (MI group). Five patients (25%) in the MVP group and two patients (33%) in the MI group had late potentials before exercise. Late potentials in the MI group did not disappear with exercise, whereas they disappeared with exercise in two patients in the MVP group. The results suggest that the late potentials observed in patients with MVP differ in nature from those with old myocardial infarction and are not always related to lethal arrhythmia.


Evaluation of Myocardial Sympathetic Nerve Function in Patients With Mitral Valve Prolapse Using Iodine-123-Metaiodobenzylguanidine Myocardial Scintigraphy

123I-Metaiodobenzylguanidine心筋シンチグラフィーによる僧帽弁逸脱の交感神経機能評価


INTRACELLULAR AND EXTRACELLULAR Ca2+REGULATE HISTAMINE-INDUCED RELEASE OF NITRIC OXIDE IN VASCULAR ENDOTHELIAL CELLS AS SHOWN WITH SENSITIVE AND SELECTIVE NITRIC OXIDE ELECTRODES


A 90-year old patient with atrial septal defect and sinus rhythm

A 90-year old patient with an atrial septal defect (ASD) and sinus rhythm, but no history of atrial fibrillation of heart failure is presented. Literature searches revealed no similar report of such a case. In addition, this patient represents the oldest documented patients with ASD associated and sinus rhythm.


特発性心筋症における初期QRSベクトルの信号源

特発性心筋症における初期QRSベクトルの信号源

The Journal of Japan Biomagnetism and Bioelectromagnetics Society


L-アルギニン静脈注射による自律神経活動の影響:心拍変動解析による検討

L-アルギニン静脈注射による自律神経活動の影響:心拍変動解析による検討


長時間運動負荷後の回復過程のエネルギー代謝と自律神経活動の検討‐呼気ガス分析と心拍変動解析による検討


Heart rate variability during painful medical procedures(Percutaneous ethanol injection therapy)

Electrocardiology '96 from the cell to the body surface


MCI-154 activates the Ca2+-activated K+ channel of vascular smooth muscle cells


僧帽弁逸脱における運動負荷時の心拍変動スペクトルの検討

僧帽弁逸脱における運動負荷時の心拍変動スペクトルの検討


前壁心筋梗塞症および健常例の初期QRSベクトルの信号源推定

前壁心筋梗塞症および健常例の初期QRSベクトルの信号源推定


Nonendothelial-derived nitric oxide activates the K+ channels in cultured vascular smooth muscle cells


僧帽弁逸脱における血中遊離型および硫酸抱合型カテコールアミンの変動

僧帽弁逸脱における血中遊離型および硫酸抱合型カテコールアミンの変動


Noninvasive localization of accessory pathways by magnetocardiographic imaging

The magnetocardiogram (MCG) is a newly developed method that helps localize a cardiac current source. To test the clinical accuracy of a 7-channel biomagnetic system in the localization of early ventricular depolarization sites, the MCGs of 14 patients with Wolff-Parkinson-White (WPW) syndrome were recorded in a radiofrequency-shielded room. The locations of early ventricular depolarization sites were classified by standard 12-lead electrocardiograms (ECGs) and body surface isopotential mapping. The accessory pathways of 3 patients with WPW syndrome were located in the right free wall and in 11 patients in the left free wall. The three-dimensional (3-D) dipole location was computed every 2 ms from the onset of the QRS complex by the least-square method. These 3-D dipole locations were projected onto a gated magnetic resonance image in order to visualize the propagation of the calculated ventricular source. The results were compared with those obtained by body surface isopotential mapping, and electrocardiographic and electrophysiologic studies. The location of the deduced current dipole at 20 ms correlated well with the location of the accessory pathway by the body surface mappings in 12 of the 14 patients with WPW syndrome. The MCG is capable of precisely determining the 3-D location of a current source in a noninvasive manner and may be of potential benefit in the treatment of WPW syndrome by catheter ablation.


Atrial Natriuretic Factor and Isosorbide Dinitrate Modulate the Gating of ATP-Sensitive K+ Channels in Cultured Vascular Smooth Muscle Cells


Effects of vesnarinone (OPC-8212) on Ca(2+)-activated K channels and cytosolic Ca2+ in cultured smooth muscle cells from porcine coronary artery.

Vesnarinone is a new, non vasodilating cardiotonic agent. This study compared the effects of vesnarinone and amrinone, a phosphodiesterase (PDE) inhibitors with vasodilating actions, on cultured smooth muscle cells from the porcine coronary artery. Application of vesnarinone (10(-4) M) or amrinone (10(-4) M) to the bath solution in cell-attached patches activated the KCa channel having a conductance of 133 pS (bath 2.7 mM K, pipette 140 mM K). Application of vesnarinone to the cytosolic side had no direct effect on KCa channel activities in inside-out patches. Activation of the KCa channel was suppressed when the intracellular production of cAMP was suppressed by preincubation with carbachol (10(-6) M). Amrinone, but not vesnarinone, lowered [Ca2+]i in the K(+)-depolarized smooth muscle cells (K+ = 70 mM). These results suggest that vesnarinone exerts an additional effect on [Ca2+]i that is independent of PDE inhibition. The difference in the effects on [Ca2+]i in vascular smooth muscle cells may explain in part the differing actions of these agents on vascular relaxation.


Effects of Vesnarinone(OPC-8212)on Ca2+-Activated K Channels and Cytosolic Ca2+- in Cultured Smooth Muscle Cells from Porcine Coronary Artery


Hemopneumothorax secondary to multiple cavitary metastasis in angiosarcoma of the scalp

We report a case of hemopneumothorax secondary to multiple cavitary metastasis in the angiosarcoma of the scalp in an 86-year-old woman, who died of respiratory failure. At autopsy, multiple cavities were found in both lungs. Histologic specimen of the cavitary metastasis of the lung showed that tumor cells proliferated forming several tubular spaces and these tubular spaces seemed to communicate with the central cyst. These findings suggested that imperfect vessel-like structures of the cavitary metastasis are likely to break down and finally grow up to large thin-walled cavities.


僧帽弁逸脱における血中遊離型および硫酸抱合型カテコラミンの変動

僧帽弁逸脱における血中遊離型および硫酸抱合型カテコラミンの変動


心磁図法によるPベクトルの位置推定

心磁図法によるPベクトルの位置推定


肝硬変患者における自律神経機能:体表面平均加算化心電図法を用いた検討

肝硬変患者における自律神経機能:体表面平均加算化心電図法を用いた検討


心磁図法による心房性再分極波(Ta波)の検討

心磁図法による心房性再分極波(Ta波)の検討


心筋梗塞症の初期QRSベクトルと心室再分極ベクトル-心磁図法による電流源の位置

心筋梗塞症の初期QRSベクトルと心室再分極ベクトル-心磁図法による電流源の位置


Time- and frequency-domain analyses of signal averaged electrocardiograms in patients with diabetes mellitus

We recorded the signal-averaged electrocardiography (SAECG) of patients with diabetic retinopathy in order to clarify whether a ventricular conduction disturbance can be detected by time- or frequency-domain analysis of the SAECG. Twenty-four normal subjects (N group) and 20 patients with diabetic retinopathy [diabetes mellitus (DM) group] were studied. On time-domain analysis, the duration of the filtered QRS (f-QRS), the duration of the terminal QRS below 40 microV (LAS40) and the root-mean-square amplitude of the terminal 40 msec (RMS40) were measured. The frequency-domain analysis was performed using two windows. In each window, the ratio of the area under the spectral curve from 40 to 100 Hz was compared with that from 0 to 40 Hz and the area from 20 to 50 Hz was compared with that from 0 to 20 Hz. The LAS40 of the DM group was significantly prolonged when compared with the N group. The area ratio from 40 to 100 Hz versus 0 to 40 Hz significantly increased in the DM group when compared with the N group. These results suggest that SAECG can be used to detect abnormal electrical signals due to diabetic microangiopathy. Moreover, high frequency components of 40 to 100 Hz at the terminus of the QRS wave were most sensitive for abnormalities due to diabetic microangiopathy.


Circadian profile of heart rate variability in mitral valve prolapse syndrome


Time- and frequency-domain heart rate variabilities in patients with liver cirrhosis


Relationship between the ischemic myocardium and focus of ventricular tachycardia in old myocardial infarction


effects of tarazosin hydrochloride on glucose metabolism and serum lipids in diabetic patients with essential hypertension

耐糖能異常を合併した本態性高血圧患者における塩酸テラゾシン(バソメット)の降圧効果と糖·脂質代謝に対する影響


心房興奮伝播のMRI画像上の表示‐心磁図法による電流dipoleの位置推定‐

心房興奮伝播のMRI画像上の表示‐心磁図法による電流dipoleの位置推定‐


Prediction of the site of origin of ventricular premature beat by magnetocardiogram

心臓磁界測定による心室性期外収縮の心室最早期興奮部位の推定

心磁図による診断法を確立するために，生体内の電流源を三次元的に推定する心磁図法と，心電図同期MRI断層法を併用して，心室性期外収縮発生源の位置を推定した．推定された値は，体表面電位図法から推定される発生源とほぼ一致し，診断学的にも有用であることがわかった．


健常者の右側胸部誘導心電図所見に関する検討

健常者の右側胸部誘導心電図所見に関する検討


心磁図の臨床応用‐心室性不整脈の発生源の推定‐

心磁図の臨床応用‐心室性不整脈の発生源の推定‐


SQUIDを用いた心房興奮伝播のMRI画像上の表示

SQUIDを用いた心房興奮伝播のMRI画像上の表示

The Journal of Japan Biomagnetism and Bioelectromagnetics Society


心室性不整脈の発生源の推定-心電図と心磁図の比較

心室性不整脈の発生源の推定-心電図と心磁図の比較


7チャンネルSQUID磁束計による心臓磁界計測およびdipoleの位置推定

7チャンネルSQUID磁束計による心臓磁界計測およびdipoleの位置推定


ホルター心電図による心房細動例の心電図的検討

ホルター心電図による心房細動例の心電図的検討

徳島県臨床衛生検査技師会誌

徳島県臨床衛生検査技師会誌


Single moving dipole obtained from magnetic field of the heart in patients with left ventricular hypertrophy

Magnetocardiograms (MCGs) were recorded by means of a second-derivative SQUID (superconducting quantum interference device) magnetometer in 20 normal subjects and 28 patients with left ventricular overload to analyze the activation sequence of the heart and amplitude of estimated current source. In the normal subjects, the dipole was directed to the left and gradually superiorly 40 ms after the beginning of the QRS wave mainly due to the activation of the left ventricle. In the patients with hypertension, the direction and location of the dipoles were similar to those of the normal subjects, but their dipole moments were increased. In the patients with mitral regurgitation, the dipoles of late QRS were directed more inferiorly than in the normal subjects and their amplitude was increased. In the patients with aortic valve disease, the amplitude of the dipoles was increased markedly and their location was deviated more to the left than the dipoles of the normal subjects. We established the criterion for diagnosis of LVO from the dipole moment of 50 ms of 3.13 x 10(-3) A or more. The sensitivity of this criterion is significantly higher in the diagnosis of left ventricular overload than the electrocardiogram (ECG). The present study shows that the moving dipole method is useful to determine the increased electromotive force in patients with left ventricular overload and that sensitivity in diagnosis of left ventricular overload is increased.

Single moving dipole法により，高血圧，僧帽弁閉鎖不全，大動脈弁狭窄の症例について，推定dipoleの値を経時的定量的に求めた．健常例との比較により診断率の精度を比較検討し，各疾患の特徴と診断基準を明らかにした．


Endothelin blocks ATP-sensitive K+ channels and depolarizes smooth muscle cells of porcine coronary artery


Effects of vasopressin on K+ channels of vascular smooth muscle cells


冠動脈平滑筋細胞におけるEndothelinの作用

冠動脈平滑筋細胞におけるEndothelinの作用


健常者の肺気量変動に伴う心電図変化に関する検討

健常者の肺気量変動に伴う心電図変化に関する検討

徳島県臨床衛生検査技師会誌

徳島県臨床衛生検査技師会誌


Signal-averaging electrocardiogram in patients with diabetes mellitus


Diurnal variation of QT interval and prevalence of arrhythmia in idiopathic mitral valve prolapse

僧帽弁逸脱例におけるQT間隔日内変動様式と不整脈発生状況に関する検討


Vector U loop in patients with old myocardial infarction

The U loop of the vectorcardiogram was examined qualitatively and quantitatively in 100 normal subjects and 67 patients with old myocardial infarction, using a direct-writing vectorcardiograph with memory function. In the control group, the U loop was directed to the left, anteriorly and inferiorly, and it was inscribed counterclockwise in the horizontal plane. In patients with anterior myocardial infarction, the U loop tended to be displaced to the right, and in patients with inferior myocardial infarction to the right and superiorly. The shape of the U loop in patients was also different from that of normal subjects. The maximum U vector was significantly smaller in magnitude both in patients with anterior and inferior myocardial infarction than that of normal subjects (p less than 0.01). In patients with ventricular aneurysm, the magnitude of the maximum U vector was significantly smaller and its direction was displaced more to the right and posteriorly than those without aneurysm (p less than 0.01). In standard 12-lead electrocardiogram (ECG), observation of the U wave in patients with old myocardial infarction was difficult, especially in the limb lead, because of the small size of the U wave. Therefore, vectorcardiographic observation may be more useful than electrocardiographic observation for the analysis of the U wave in patients with old myocardial infarction.


インテイジェント化心電計の診断精度に関する検討

インテイジェント化心電計の診断精度に関する検討

徳島県臨床衛生検査技師会誌

徳島県臨床衛生検査技師会誌


Diurnal variation of the QT interval and effects of beta-receptor blockade in idiopathic mitral valve prolapse

僧帽逸脱におけるQT間隔日内変動様式とβ遮断剤の投与効果に関する検討


ホルター式長時間呼吸·心電図記録装置による健常者無呼吸発作の観察

ホルター式長時間呼吸·心電図記録装置による健常者無呼吸発作の観察


The P wave of the magnetocardiogram (MCG) was investigated in normal subjects and in patients with right and left atrial overloading. In normal subjects, the MCG P wave was positive at right lower sternal sites and negative in the other portions. The current source deduced from the MCG and the isomagnetic map was directed inferiorly and to the left throughout the entire phase of atrial activation. In patients with right atrial overloading, the direction of the current source deduced from the MCG was similar to that of normal subjects, but its amplitude was significantly greater. In left atrial overloadings, a negative-positive biphasic P wave was seen more frequently than in normal subjects at left parasternal sites. In the late phase of atrial activation, the MCG could detect the two dipoles, i.e. one directed inferiorly and other directed to the left. These dipoles might correspond to right and left atrial activities, respectively. These results show that the MCG might add useful information on current source to the conventional electrocardiogram.


Isomagnetic maps in right ventricular overloading

Isomagnetic maps were recorded in normal subjects and in patients with systolic overloading of the right ventricle. The isomagnetic maps examined in this study indicated the instantaneous current source of the heart by applying the "corkscrew rule." The magnetic field recorded by a second derivative gradiometer detected clearly the cardiac current source from the right ventricle, which is located close to the anterior chest wall, and improved diagnostic sensitivity. Moreover, the isomagnetic map showed multiple dipoles, which are difficult to detect in the electrocardiogram or isopotential map. These results suggest that the magnetocardiogram provides useful information on current sources to supplement information obtained by the conventional electrocardiogram.


Vector U loop in patients with left ventricular overloading


Vector U loop in patients with right ventricular overloading

The U loop of the vectorcardiogram (VCG) was examined qualitatively and quantitatively in 126 normal subjects, 15 subjects with complete right bundle branch block (CRBBB group) and 58 patients with right ventricular overloading (RVO group), using a direct-writing vectorcardiograph with memory function. In normal subjects the U loop was directed similarly to the T loop, i.e., to the left, anteriorly and inferiorly. In the CRBBB group, maximum U vector was smaller, but its direction was not significantly different from that in normal subjects. In the RVO group, the U loop tended to be displaced posteriorly and to the left and was significantly greater in magnitude than that in normal subjects in the horizontal (P less than 0.01) and frontal (P less than 0.001) planes. In the RVO group, a good correlation was found between the direction of maximum U vector and right ventricular systolic pressure. In some cases of the RVO group, the U loop was the only abnormality suggesting right ventricular overloading. These findings suggest that abnormality of the U loop is a good indicator in a diagnosis of right ventricular overloading.


心室期外収縮に対するDisopyramideの抑制効果 --- ホルター心電図を用いた効果判定

The Japanese journal of clinical and experimental medicine


非観血的連続記録血圧計による健常者の血圧日内変動様式の観察

非観血的連続記録血圧計による健常者の血圧日内変動様式の観察


Characteristics of ATPase activity and the subunit composition of myosin in the conduction system of bovine heart

The ATPase activity, light chains and isoenzymes of myosin from specialized myocardial tissue (the A-V node, bundle of His, and right and left bundle branches) of bovine heart were compared with those of atrial and ventricular myosins. The order of Ca2+-activated ATPase activity was atrial greater than specialized myocardial tissue greater than ventricular myosin. SDS-polyacrylamide gel electrophoresis showed that myosin from the specialized myocardial tissue contained the light chains of both atrial and ventricular myosins. On the other hand, the specialized myocardial tissue contained one V3 isomyosin and showed no difference from ventricular myocardial tissue on pyrophosphate gel.


実時間処理型ホルター心電計(PECGASYS)の心拍数および心室性期外収縮検出の信頼性に関する検討


CHARACTERISTICS OF NON-SUSTAINED VENTRICULAR TACHYCARDIA DETECTED BY AMBULATORY ELECTROCARDIOGRAPHY


Electrocardiographic features of ventricular tachycardia --- especialiy its relationship to premature ventricular complexes

心室性頻拍症の心電図的特徴 --- とくに心室性期外収縮との関連性

Journal of Clinical and Experimental Medicine


心臓刺激伝導系ミオシンのアイソザイムおよびATPase活性

心臓刺激伝導系ミオシンのアイソザイムおよびATPase活性


EFFECTS OF ELASTASE ON THE MYOCARDIAL DISORDERS OF KK MICE

自然発症糖尿病マウス(KKマウス)の心筋病変(特にカルシウム沈着)に対するエラスターゼの効果


Clinical characteristics of ventricular tachycardia

心室性頻拍症の臨床的検討


Study of the sinus node function in active elderly subjects:Evaluation of diurnal variation of heart rate by ambulatory electrocardiography

高年者の洞機能に関する研究ーHolter心電図による心拍数日内変動の検討ー


CYCLIC ADENOSINE 3',5'-MONOPHOSPHATE, ADENYL CYCLASE AND PHOSPHODIESTERASE IN THE CONDUCTION SYSTEM OF BOVINE HEART


自然発症糖尿病マウス(KKマウス)の心筋障害の成因に関する研究

自然発症糖尿病マウス(KKマウス)の心筋障害の成因に関する研究


心臓刺激伝導系(特殊心筋)のミオシンBの超沈澱およびATPase活性に関する研究


Comparison of Superprecipitation and Contractile Protein Contents of Myosin B in the Myocardium and Conduction System


心臓刺激伝導系(特殊心筋)のミオシン各鎖の定量的検討

心臓刺激伝導系(特殊心筋)のミオシン各鎖の定量的検討


心臓刺激伝導系(特殊心筋)のミオシンBの超沈澱現象に関する研究

心臓刺激伝導系(特殊心筋)のミオシンBの超沈澱現象に関する研究


Studies on myosin and Na+,K+-ATPase of the bovine cardiac conduction system

ウシ心臓刺激伝導系のミオシンおよびNa+，K+-ATPaseに関する研究


Comparison of the subunit compositions and ATPase activities of myosin in the myocardium and conduction system

Journal of Molecular and Cellular Cardiology


Studies on characterization of contractile proteins of the cardiac conduction system of bovine heart

心臓刺激伝導系の収縮蛋白に関する研究


狭心症に対するニトログリセリン軟膏の使用経験

狭心症に対するニトログリセリン軟膏の使用経験


心臓刺激伝導系(特殊心筋)のmyosin light chainに関する研究

心臓刺激伝導系(特殊心筋)のmyosin light chainに関する研究


各種不整脈に対するdisopyramideの効果

各種不整脈に対するdisopyramideの効果

The Japanese journal of clinical and experimental medicine


先天性左心外膜部分欠損症の1例 --- 特にその頸静脈波変化に関する検討

先天性左心外膜部分欠損症の1例 --- 特にその頸静脈波変化に関する検討


先天性左心膜欠損症の二例

先天性左心膜欠損症の二例


Source localization of initial QRS vector in patients with idiopathic cardiomyopathy : Comparison with normal subjects and patients with anterior myocardial infarction.


長時間運動後のエネルギー代謝におよぼす影響

長時間運動後のエネルギー代謝におよぼす影響


Analysis of heart rate variability and its clinical application by Holter ECG recordings

ホルター心電図による心拍変動の解析とその臨床的意義

Bulletin of School of Medical Sciences, the University of Tokushima

徳島大学医療技術短期大学部紀要


Diagnostic accuracy of arrhythmias in semi-automatic analysis by Fukuda-Holter system(SCM-280)

ホルター心電計の不整脈診断精度に関する検討

徳島大学医療技術短期大学部紀要


Diurnal variation of the QT intervals in idiopathic mitral valve prolapse

僧帽弁逸脱におけるQT間隔日内変動様式の検討

Diurnal variation of QT intervals was analyzed using Holter monitoring for 44 patients with mitral valve prolapse (MVP), and the relationship between ECG changes and autonomic nervous dysfunction was assessed by measuring blood catecholamine during bicycle ergometer exercise and various autonomic functional tests. The following results were obtained. 1. The QT intervals in MVP patients had greater diurnal variations and the averaged QTc was in a high level all the time. 2. Positivity of the autonomic functional tests and the catecholamine level after exercise were significantly high in patients of MVP. 3. After catecholamine depletion by beta-blocking agent (carteolol: 15 mg a day, 5 to 12 months' duration), the variation of QTc became less marked. These data indicate the presence of autonomic dysfunction in patients of MVP.