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en: The intestinal microbiota and its role in human health and disease

en: The role of the intestinal microbiota in human health is gaining more attention since clear changes in the composition of the intestinal bacteria or environment are seen in patients with inflammatory bowel disease, allergy, autoimmune disease, and some lifestyle-related illnesses. A healthy gut environment is regulated by the exquisite balance of intestinal microbiota, metabolites, and the host's immune system. Imbalance of these factors in genetically susceptible persons may promote a disease state. Manipulation of the intestinal microbiota with prebiotics, which can selectively stimulate growth of beneficial bacteria, might help to maintain a healthy intestinal environment or improve diseased one. In this review, analytical methods for identification of intestinal bacteria and an update on the correlation of the intestinal microbiota with human health and disease were discussed by introducing our recent studies to determine the prebiotic effects of a fiber-rich food in animal model and on healthy people and patients with ulcerative colitis (UC).

en: The Journal of Medical Investigation : JMI


en: Intestinal microbiota and its role in human health

ja: ヒトの健康保持における腸内菌の役割

en: The healthy gut environment is complicated and controlled by the balance of intestinal immune system, intestinal microbiota, and microbial metabolites produced by intestinal bacteria. Imbalance of these elements in genetically susceptible persons has been known to promote inflammatory bowel disease and some lifestyle-related illnesses. Manipulation of intestinal microbiota with prebiotics, which can selectively stimulate a growth of beneficial bacteria, might contribute to keep healthy condition and to improve patient's condition. I present some results of prebiotic effects in animal model and placebo-controlled, crossover study in healthy adults and patients with ulcerative colitis (UC). Through the clinical study, we found that UC patients had differences in microbiota composition and microbial metabolites. Decrease of Dominant anaerobic bacteria Bacteroides and diversity of microbiota composition was observed in UC. Amount of organic acids produced by bacterial fermentation reflectively decreased. Update on correlation of intestinal bacteria with human health and disease are reviewed.

en: Shikoku Acta Medica

ja: 四国医学雑誌


en: 大腸前癌病変発生に対する腸内菌の影響

ja: 大腸前癌病変発生に対する腸内菌の影響

en: Journal of Japanese Society for Gastroenterological Carcinogenesis

ja: 消化器癌の発生と進展