type: misc

label: url

en: 周術期の血管機能保護戦略

ja: 周術期の血管機能保護戦略

en: Potassium channels play an essential role in the membrane potential of arterial smooth muscle, and also in regulating contractile tone. Especially, in vascular smooth muscle, the opening of adenosine triphosphate(ATP)-sensitive potassium(KATP)channels leads to membrane hyperpolarization, resulting in muscle relaxation and vasodilation. This activation also plays a role in tissues during pathophysiologic events such as ischemia, hypoxia, and vasodilatory shock. In this review, we will describe the physiological and pathophysiological roles of vascular smooth muscle KATP channels in relation to the effects of anesthetics and perioperative managements. Although accumulated evidence suggests that many anesthetics and perioperative managements(especially, diabetes and hyperglycemia)modify the above function of K+ channels as a metabolic sensor. Use of effective volatile anesthetics and the strict glycemic control may contribute to protect perioperative vascular function.

en: Shikoku Acta Medica

ja: 四国医学雑誌


en: 2.カリウムチャネルと循環 --- 第37回総会シンポジウム2「神経調節による循環制御」

en: 循環制御

ja: 循環制御


en: Principles, Usefulness, and Limitations of Recent Circulatory Monitoring --- 「循環系:心拍出量モニタリングを中心に」

ja: 特集 モニタリングを検証する --- 「循環系:心拍出量モニタリングを中心に」

en: Masui

ja: 麻酔


en: Intensive insulin therapy during cardiovascular surgery.

en: Recent evidence in the fields of surgery, emergency and critical care medicine indicates that strict glycemic control results in lower mortality. Hyperglycemia occurs frequently in patients with and without diabetes during cardiovascular surgery, especially during cardiopulmonary bypass. However, strict glucose control is difficult to achieve during cardiovascular procedures. To establish effective intensive insulin therapy during cardiovascular surgery, we conduct continuous blood glucose monitoring and employ automatic control by using an artificial endocrine pancreas (the STG-22, Nikkiso, Tokyo, Japan). In this review, we will outline the present status and problems of conventional glycemic control for perioperative cardiovascular surgery and introduce the new perioperative blood glucose management method that we are testing now. We will also discuss the importance of perioperative glycemic control for cardiovascular surgery as well as future prospects.

en: The Journal of Medical Investigation : JMI


en: Problems associated with glucose toxicity: Role of hyperglycemia-induced oxidative stress.

en: Glucose homeostasis deficiency leads to a chronic increase in blood glucose concentration. In contrast to physiological glucose concentration, chronic superphysiological glucose concentration negatively affects a large number of organs and tissues. Glucose toxicity means a decrease in insulin secretion and an increase in insulin resistance due to chronic hyperglycemia. It is now generally accepted that glucose toxicity is involved in the worsening of diabetes by affecting the secretion of beta-cells. Several mechanisms have been proposed to explain the adverse effects of hyperglycemia. It was found that persistent hyperglycemia caused the functional decline of neutrophils. Infection is thus the main problem resulting from glucose toxicity in the acute phase. In other words, continued hyperglycemia is a life-threatening risk factor, not only in the chronic but also the acute phase, and it becomes a risk factor for infection, particularly in the perioperative period.

en: World Journal of Gastroenterology : WJG

ja: World Journal of Gastroenterology : WJG


en: 2. 虚血性心疾患 TEEセミナー「私のルーチン」

ja: 2. 虚血性心疾患 TEEセミナー「私のルーチン」

en: Cardiovascular Anesthesia

ja: Cardiovascular Anesthesia


en: 心エコー・ドプラ法の新技術 --- -後方散乱エコーとストレイン/ストレインレート-

en: 日本臨床麻酔学会誌

ja: 日本臨床麻酔学会誌


en: 小児麻酔における経食道心エコーの功罪

ja: 小児麻酔における経食道心エコーの功罪


en: 令和6年度 徳島大学高等教育研究センターアドミッション部門 報告書

ja: 令和6年度 徳島大学高等教育研究センターアドミッション部門 報告書

en: 令和6年度 徳島大学高等教育研究センターアドミッション部門 報告書

ja: 令和6年度 徳島大学高等教育研究センターアドミッション部門 報告書

misc_type: others


en: 令和5年度 徳島大学高等教育研究センターアドミッション部門 報告書

ja: 令和5年度 徳島大学高等教育研究センターアドミッション部門 報告書

en: 令和5年度 徳島大学高等教育研究センターアドミッション部門 報告書

ja: 令和5年度 徳島大学高等教育研究センターアドミッション部門 報告書


en: 慢性疼痛診療モデル事業報告会・シンポジウム

ja: 慢性疼痛診療モデル事業報告会・シンポジウム

en: 令和4年度厚生労働省 慢性疼痛診療システム均てん化事業四国地区「慢性の痛み診療のための多職種・多診療科・地域との連携」報告書