{"insert":{"user_id":"1000242796","type":"published_papers","id":"49763624"},"force":{"see_also":[{"@id":"https://tokushima-u.repo.nii.ac.jp/records/2013713","label":"url"},{"@id":"https://www.scopus.com/pages/publications/86000736357","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=419705","label":"url"}],"paper_title":{"en":"Effect of halloysite nanotubes on poloxamer 407-containing calcium phosphate cement for bone repair applications","ja":"Effect of halloysite nanotubes on poloxamer 407-containing calcium phosphate cement for bone repair applications"},"authors":{"en":[{"name":"Kim Yeeun"},{"name":"Sekine Kazumitsu"},{"name":"Hamada Kenichi"}],"ja":[{"name":"キム イエウン"},{"name":"関根 一光"},{"name":"浜田 賢一"}]},"publication_date":"2025-03-11","publication_name":{"en":"Ceramics International","ja":"Ceramics International"},"referee":true,"identifiers":{"doi":["10.1016/j.ceramint.2025.03.132"],"issn":["0272-8842"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"1000242796","type":"published_papers","id":"39213766"},"force":{"see_also":[{"@id":"https://tokushima-u.repo.nii.ac.jp/records/2009913","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/35264547","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=384672","label":"url"}],"paper_title":{"en":"Effect of immersion in NaCl solution on the electrical conductivity and the reduction of the shear bond strength of resin-modifi ed glass-ionomer-cements after current application","ja":"Effect of immersion in NaCl solution on the electrical conductivity and the reduction of the shear bond strength of resin-modifi ed glass-ionomer-cements after current application"},"authors":{"en":[{"name":"Matsuki Yuta"},{"name":"Sato Hiroko"},{"name":"Kajimoto N,"},{"name":"Takegawa Emi"},{"name":"Horiuchi Shinya"},{"name":"Sekine Kazumitsu"},{"name":"Tanaka Eiji"},{"name":"Hamada Kenichi"}],"ja":[{"name":"松木 祐太"},{"name":"佐藤 博子"},{"name":"梶本 昇"},{"name":"武川 恵美"},{"name":"堀内 信也"},{"name":"関根 一光"},{"name":"田中 栄二"},{"name":"浜田 賢一"}]},"publication_date":"2022-05","publication_name":{"en":"Dental Materials Journal","ja":"Dental Materials Journal"},"volume":"41","number":"3","starting_page":"487","ending_page":"494","languages":["eng"],"referee":true,"identifiers":{"doi":["10.4012/dmj.2021-322"],"issn":["1881-1361"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"1000242796","type":"published_papers","id":"30550703"},"force":{"see_also":[{"@id":"https://tokushima-u.repo.nii.ac.jp/records/2007657","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/32779608","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=363572","label":"url"}],"paper_title":{"en":"Effects of water immersion on shear bond strength reduction after current application of resin-modified glass-ionomer-cements containing and not containing an ionic liquid.","ja":"Effects of water immersion on shear bond strength reduction after current application of resin-modified glass-ionomer-cements containing and not containing an ionic liquid."},"authors":{"en":[{"name":"Sato Hiroko"},{"name":"Matsuki Yuta"},{"name":"Kajimoto N,"},{"name":"Takegawa Emi"},{"name":"Horiuchi Shinya"},{"name":"Sekine Kazumitsu"},{"name":"Tanaka Eiji"},{"name":"Hamada Kenichi"}],"ja":[{"name":"佐藤 博子"},{"name":"松木 祐太"},{"name":"梶本 昇"},{"name":"武川 恵美"},{"name":"堀内 信也"},{"name":"関根 一光"},{"name":"田中 栄二"},{"name":"浜田 賢一"}]},"description":{"en":"The enhancement in the bonding strength of advanced dental cements has enabled long-lasting dental restorations. However, the high bonding strength can cause difficulty in removing these restorations. Therefore, \"smart\" dental cements with simultaneous strong bonding and easy on-demand debonding ability are required. A resin-modified glass-ionomer-cement (RMGIC) with an ionic liquid (IL) has demonstrated significant reduction in the bonding strength with current application (CA). This research investigates the effect of immersion in distilled water on the electric conductivity and bonding strength of RMGIC with and without an IL and CA. The RMGIC without the IL exhibited significant electric conductivity after immersion, and a significant decrease in bonding strength with CA. In comparison, the electric conductivity after immersion and the decrease in bonding strength with CA were greater for RMGIC with the IL. Thus, the feasibility of smart dental cements capable of electrically debonding-on-demand is indicated.","ja":"The enhancement in the bonding strength of advanced dental cements has enabled long-lasting dental restorations. However, the high bonding strength can cause difficulty in removing these restorations. Therefore, \"smart\" dental cements with simultaneous strong bonding and easy on-demand debonding ability are required. A resin-modified glass-ionomer-cement (RMGIC) with an ionic liquid (IL) has demonstrated significant reduction in the bonding strength with current application (CA). This research investigates the effect of immersion in distilled water on the electric conductivity and bonding strength of RMGIC with and without an IL and CA. The RMGIC without the IL exhibited significant electric conductivity after immersion, and a significant decrease in bonding strength with CA. In comparison, the electric conductivity after immersion and the decrease in bonding strength with CA were greater for RMGIC with the IL. Thus, the feasibility of smart dental cements capable of electrically debonding-on-demand is indicated."},"publication_date":"2021-01","publication_name":{"en":"Dental Materials Journal","ja":"Dental Materials Journal"},"volume":"40","number":"1","starting_page":"35","ending_page":"43","languages":["eng"],"referee":true,"identifiers":{"doi":["10.4012/dmj.2019-371"],"issn":["1881-1361"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"1000242796","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://tokushima-u.repo.nii.ac.jp/records/2004903","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/29848856","label":"url"},{"@id":"https://www.scopus.com/pages/publications/85056973389","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=337897","label":"url"}],"paper_title":{"en":"Electrical shear bonding strength reduction of resin-modified glass-ionomer-cement containing ionic-liquid concept and validation of a smart dental cement debonding-on-demand","ja":"Electrical shear bonding strength reduction of resin-modified glass-ionomer-cement containing ionic-liquid concept and validation of a smart dental cement debonding-on-demand"},"authors":{"en":[{"name":"Kajimoto Noboru"},{"name":"Takegawa Emi"},{"name":"Sekine Kazumitsu"},{"name":"Hamada Kenichi"}],"ja":[{"name":"Kajimoto Noboru"},{"name":"武川 恵美"},{"name":"関根 一光"},{"name":"浜田 賢一"}]},"description":{"en":"With improvement of bonding strength of recent dental cement, it is difficult nowadays to remove restorations without excessive force or vibration to tooth, occasionally resulting in damage of dentin, enamel, and dental root. Therefore, \"smart\" dental cement indicating strong bonding and easy debonding-on-demand simultaneously is required. In this research, resin-modified glass-ionomer-cement containing an ionic-liquid, tris(2-hydroxyethyl)methylammonium methylsulfate was produced, and the shear bonding strength before and after direct current application were evaluated. The prototype cement containing 15 to 20 mass% ionic-liquid indicated simultaneously no significant reduction of shear bonding strength from that of the original cement not containing ionic-liquid, and significant reduction of bonding strength to approximately 20% of that of the original cement after direct current application of more than 2 mmC/mm. The prototype cement in this research demonstrated that the concept of smart dental cement electrically debonding-on-demand is feasible.","ja":"With improvement of bonding strength of recent dental cement, it is difficult nowadays to remove restorations without excessive force or vibration to tooth, occasionally resulting in damage of dentin, enamel, and dental root. Therefore, \"smart\" dental cement indicating strong bonding and easy debonding-on-demand simultaneously is required. In this research, resin-modified glass-ionomer-cement containing an ionic-liquid, tris(2-hydroxyethyl)methylammonium methylsulfate was produced, and the shear bonding strength before and after direct current application were evaluated. The prototype cement containing 15 to 20 mass% ionic-liquid indicated simultaneously no significant reduction of shear bonding strength from that of the original cement not containing ionic-liquid, and significant reduction of bonding strength to approximately 20% of that of the original cement after direct current application of more than 2 mmC/mm. The prototype cement in this research demonstrated that the concept of smart dental cement electrically debonding-on-demand is feasible."},"publication_date":"2018-05","publication_name":{"en":"Dental Materials Journal","ja":"Dental Materials Journal"},"volume":"37","number":"5","starting_page":"768","ending_page":"774","languages":["eng"],"referee":true,"identifiers":{"doi":["10.4012/dmj.2017-361"],"issn":["1881-1361"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"1000242796","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://tokushima-u.repo.nii.ac.jp/records/2005142","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/28450674","label":"url"},{"@id":"https://www.scopus.com/pages/publications/85030149005","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=323603","label":"url"}],"paper_title":{"en":"Effects of powder-to-liquid ratio on properties of β-tricalcium-phosphate cements modified using high-energy ball-milling","ja":"Effects of powder-to-liquid ratio on properties of β-tricalcium-phosphate cements modified using high-energy ball-milling"},"authors":{"en":[{"name":"Ida Yumika"},{"name":"Be Jiyon"},{"name":"Sekine Kazumitsu"},{"name":"Kawano Fumiaki"},{"name":"Hamada Kenichi"}],"ja":[{"name":"伊田 百美香"},{"name":"裵 志英"},{"name":"関根 一光"},{"name":"河野 文昭"},{"name":"浜田 賢一"}]},"description":{"en":"The authors have developed a β-tricalcium-phosphate (β-TCP) powder modified mechano-chemically through the application of a ball-milling process (mβ-TCP). The resulting powder can be used in a calcium-phosphate-cement (CPC). In this study, the effects of the powder-to-liquid ratio (P/L ratio) on the properties of the CPCs were investigated, and an appropriate P/L ratio that would simultaneously improve injectability and strength was clarified. The mβ-TCP cement mixed at a P/L ratio of 2.5 and set in air exhibited sufficient injectability until 20 min after mixing, and strength similar to or higher than that mixed at a P/L ratio of 2.0 and 2.78. Although the mβ-TCP cements set in vivo and in SBF were found to exhibit a lower strength than those set in air, it did have an appropriate setting time and strength for clinical applications. In conclusion, P/L ratio optimization successfully improved the strength of injectable mβ-TCP cement.","ja":"The authors have developed a β-tricalcium-phosphate (β-TCP) powder modified mechano-chemically through the application of a ball-milling process (mβ-TCP). The resulting powder can be used in a calcium-phosphate-cement (CPC). In this study, the effects of the powder-to-liquid ratio (P/L ratio) on the properties of the CPCs were investigated, and an appropriate P/L ratio that would simultaneously improve injectability and strength was clarified. The mβ-TCP cement mixed at a P/L ratio of 2.5 and set in air exhibited sufficient injectability until 20 min after mixing, and strength similar to or higher than that mixed at a P/L ratio of 2.0 and 2.78. Although the mβ-TCP cements set in vivo and in SBF were found to exhibit a lower strength than those set in air, it did have an appropriate setting time and strength for clinical applications. In conclusion, P/L ratio optimization successfully improved the strength of injectable mβ-TCP cement."},"publication_date":"2017-04-26","publication_name":{"en":"Dental Materials Journal","ja":"Dental Materials Journal"},"volume":"36","number":"5","starting_page":"590","ending_page":"599","languages":["eng"],"referee":true,"identifiers":{"doi":["10.4012/dmj.2016-341"],"issn":["1881-1361"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"1000242796","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://tokushima-u.repo.nii.ac.jp/records/2003326","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=321865","label":"url"}],"paper_title":{"en":"Volume magnetic susceptibility design and hardness of Au Ta alloys and Au Nb alloys for MRI-compatible biomedical applications","ja":"Volume magnetic susceptibility design and hardness of Au Ta alloys and Au Nb alloys for MRI-compatible biomedical applications"},"authors":{"en":[{"name":"Inui Shihoko"},{"name":"Takegawa Emi"},{"name":"Hamada Kenichi"}],"ja":[{"name":"乾 志帆子"},{"name":"武川 恵美"},{"name":"浜田 賢一"}]},"publication_date":"2017-02-10","publication_name":{"en":"Biomedical Physics & Engineering Express","ja":"Biomedical Physics & Engineering Express"},"volume":"3","number":"1","starting_page":"015025","ending_page":"015025","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1088/2057-1976/aa5449"],"issn":["2057-1976"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"1000242796","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://tokushima-u.repo.nii.ac.jp/records/2003313","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/28154746","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=322006","label":"url"}],"paper_title":{"en":"Bone Ingrowth to Ti Fibre Knit Block with High Deformability","ja":"Bone Ingrowth to Ti Fibre Knit Block with High Deformability"},"authors":{"en":[{"name":"Henmi Yoko"},{"name":"Naitou Yoshihito"},{"name":"Jimbo Ryo"},{"name":"Jinno Yohei"},{"name":"Sekine Kazumitsu"},{"name":"Hamada Kenichi"}],"ja":[{"name":"邉見 蓉子"},{"name":"内藤 禎人"},{"name":"神保 良"},{"name":"神野 洋平"},{"name":"関根 一光"},{"name":"浜田 賢一"}]},"publication_date":"2016-12-23","publication_name":{"en":"Journal of Oral & Maxillofacial Research","ja":"Journal of Oral & Maxillofacial Research"},"volume":"7","number":"4","starting_page":"e2","ending_page":"e2","languages":["eng"],"referee":true,"identifiers":{"doi":["10.5037/jomr.2016.7402"],"issn":["2029-283X"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"1000242796","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://tokushima-u.repo.nii.ac.jp/records/2003187","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/27148637","label":"url"},{"@id":"https://www.scopus.com/pages/publications/84966359149","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=426043","label":"url"}],"paper_title":{"en":"Application of porous titanium in prosthesis production using a moldless process: Evaluation of physical and mechanical properties with various particle sizes, shapes, and mixing ratios","ja":"Application of porous titanium in prosthesis production using a moldless process: Evaluation of physical and mechanical properties with various particle sizes, shapes, and mixing ratios"},"authors":{"en":[{"name":"Prananingrum Widyasri"},{"name":"Tomotake Yoritoki"},{"name":"Naito Yoshihito"},{"name":"Bae Jiyoung"},{"name":"Sekine Kazumitsu"},{"name":"Hamada Kenichi"},{"name":"Ichikawa Tetsuo"}],"ja":[{"name":"Prananingrum Widyasri"},{"name":"Tomotake Yoritoki"},{"name":"Naito Yoshihito"},{"name":"Bae Jiyoung"},{"name":"Sekine Kazumitsu"},{"name":"浜田 賢一"},{"name":"Ichikawa Tetsuo"}]},"description":{"en":"The prosthetic applications of titanium have been challenging because titanium does not possess suitable properties for the conventional casting method using the lost wax technique. We have developed a production method for biomedical application of porous titanium using a moldless process. This study aimed to evaluate the physical and mechanical properties of porous titanium using various particle sizes, shapes, and mixing ratio of titanium powder to wax binder for use in prosthesis production. CP Ti powders with different particle sizes, shapes, and mixing ratios were divided into five groups. A 90:10wt% mixture of titanium powder and wax binder was prepared manually at 70°C. After debinding at 380°C, the specimen was sintered in Ar at 1100°C without a mold for 1h. The linear shrinkage ratio of sintered specimens ranged from 2.5% to 14.2%. The linear shrinkage ratio increased with decreasing particle size. While the linear shrinkage ratio of Groups 3, 4, and 5 were approximately 2%, Group 1 showed the highest shrinkage of all. The bending strength ranged from 106 to 428MPa under the influence of porosity. Groups 1 and 2 presented low porosity followed by higher strength. The shear bond strength ranged from 32 to 100MPa. The shear bond strength was also particle-size dependent. The decrease in the porosity increased the linear shrinkage ratio and bending strength. Shrinkage and mechanical strength required for prostheses were dependent on the particle size and shape of titanium powders. These findings suggested that this production method can be applied to the prosthetic framework by selecting the material design.","ja":"The prosthetic applications of titanium have been challenging because titanium does not possess suitable properties for the conventional casting method using the lost wax technique. We have developed a production method for biomedical application of porous titanium using a moldless process. This study aimed to evaluate the physical and mechanical properties of porous titanium using various particle sizes, shapes, and mixing ratio of titanium powder to wax binder for use in prosthesis production. CP Ti powders with different particle sizes, shapes, and mixing ratios were divided into five groups. A 90:10wt% mixture of titanium powder and wax binder was prepared manually at 70°C. After debinding at 380°C, the specimen was sintered in Ar at 1100°C without a mold for 1h. The linear shrinkage ratio of sintered specimens ranged from 2.5% to 14.2%. The linear shrinkage ratio increased with decreasing particle size. While the linear shrinkage ratio of Groups 3, 4, and 5 were approximately 2%, Group 1 showed the highest shrinkage of all. The bending strength ranged from 106 to 428MPa under the influence of porosity. Groups 1 and 2 presented low porosity followed by higher strength. The shear bond strength ranged from 32 to 100MPa. The shear bond strength was also particle-size dependent. The decrease in the porosity increased the linear shrinkage ratio and bending strength. Shrinkage and mechanical strength required for prostheses were dependent on the particle size and shape of titanium powders. These findings suggested that this production method can be applied to the prosthetic framework by selecting the material design."},"publication_date":"2016-04-19","publication_name":{"en":"Journal of the Mechanical Behavior of Biomedical Materials","ja":"Journal of the Mechanical Behavior of Biomedical Materials"},"volume":"61","starting_page":"581","ending_page":"589","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.jmbbm.2016.04.021"],"issn":["1751-6161"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"1000242796","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://tokushima-u.repo.nii.ac.jp/records/2013718","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/26836201","label":"url"},{"@id":"https://www.scopus.com/pages/publications/84959553425","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=426053","label":"url"}],"paper_title":{"en":"Bone ingrowth of various porous titanium scaffolds produced by a moldless and space holder technique: An in vivo study in rabbits","ja":"Bone ingrowth of various porous titanium scaffolds produced by a moldless and space holder technique: An in vivo study in rabbits"},"authors":{"en":[{"name":"Prananingrum Widyasri"},{"name":"Naito Yoshihito"},{"name":"Galli Silvia"},{"name":"Bae Jiyoung"},{"name":"Sekine Kazumitsu"},{"name":"Hamada Kenichi"},{"name":"Tomotake Yoritoki"},{"name":"Wennerberg Ann"},{"name":"Jimbo Ryo"},{"name":"Ichikawa Tetsuo"}],"ja":[{"name":"Prananingrum Widyasri"},{"name":"Naito Yoshihito"},{"name":"Galli Silvia"},{"name":"Bae Jiyoung"},{"name":"Sekine Kazumitsu"},{"name":"浜田 賢一"},{"name":"Tomotake Yoritoki"},{"name":"Wennerberg Ann"},{"name":"Jimbo Ryo"},{"name":"市川 哲雄"}]},"description":{"en":"Porous titanium has long been desired as a bone substitute material because of its ability to reduce the stress shielding in supporting bone. In order to achieve the various pore structures, we have evolved a moldless process combined with a space holder technique to fabricate porous titanium. This study aims to evaluate which pore size is most suitable for bone regeneration using our process. The mixture comprising Ti powder, wax binder and PMMA spacer was prepared manually at 70 °C which depended on the mixing ratio of each group. Group 1 had an average pore size of 60 μm, group 2 had a maximum pore size of 100 μm, group 3 had a maximum pore size of 200 μm and group 4 had a maximum pore size of 600 μm. These specimens were implanted into rabbit calvaria for three and 20 weeks. Thereafter, histomorphometrical evaluation was performed. In the histomorphometrical evaluation after three weeks, the group with a 600 μm pore size showed a tendency to greater bone ingrowth. However, after 20 weeks the group with a pore size of 100 μm showed significantly greater bone ingrowth than the other groups. This study suggested that bone regeneration into porous titanium scaffolds is pore size-dependent, while bone ingrowth was most prominent for the group with 100 μm-sized pores after 20 weeks in vivo.","ja":"Porous titanium has long been desired as a bone substitute material because of its ability to reduce the stress shielding in supporting bone. In order to achieve the various pore structures, we have evolved a moldless process combined with a space holder technique to fabricate porous titanium. This study aims to evaluate which pore size is most suitable for bone regeneration using our process. The mixture comprising Ti powder, wax binder and PMMA spacer was prepared manually at 70 °C which depended on the mixing ratio of each group. Group 1 had an average pore size of 60 μm, group 2 had a maximum pore size of 100 μm, group 3 had a maximum pore size of 200 μm and group 4 had a maximum pore size of 600 μm. These specimens were implanted into rabbit calvaria for three and 20 weeks. Thereafter, histomorphometrical evaluation was performed. In the histomorphometrical evaluation after three weeks, the group with a 600 μm pore size showed a tendency to greater bone ingrowth. However, after 20 weeks the group with a pore size of 100 μm showed significantly greater bone ingrowth than the other groups. This study suggested that bone regeneration into porous titanium scaffolds is pore size-dependent, while bone ingrowth was most prominent for the group with 100 μm-sized pores after 20 weeks in vivo."},"publication_date":"2016-02-02","publication_name":{"en":"Biomedical Materials","ja":"Biomedical Materials"},"volume":"11","number":"1","starting_page":"015012","ending_page":"015012","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1088/1748-6041/11/1/015012"],"issn":["1748-6041"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"1000242796","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/25855467","label":"url"},{"@id":"https://www.scopus.com/pages/publications/84926341883","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=291870","label":"url"}],"paper_title":{"en":"Effects of high-energy ball-milling on injectability and strength of β-tricalcium-phosphate cement","ja":"Effects of high-energy ball-milling on injectability and strength of β-tricalcium-phosphate cement"},"authors":{"en":[{"name":"Be Jiyon"},{"name":"Ida Yumika"},{"name":"Sekine Kazumitsu"},{"name":"Kawano Fumiaki"},{"name":"Hamada Kenichi"}],"ja":[{"name":"裵 志英"},{"name":"伊田 百美香"},{"name":"関根 一光"},{"name":"河野 文昭"},{"name":"浜田 賢一"}]},"description":{"en":"Calcium phosphate cement (CPC) offers many advantages as a bone-substitution material. The objective of this study is to develop a new CPC that simultaneously exhibits fine injectability, a short setting time, and high strength. β-tricalcium phosphate (β-TCP, control) powder was ball-milled for 24h to produce a new cement powder. The modified β-TCP after 24h milling (mβ-TCP-24h) exhibited excellent injectability even 1h after mixing. The mechanical properties of the set cement (compact) were evaluated using compressive strength (CS) and diametral tensile strength (DTS) testing. The CS and DTS values of the mβ-TCP-24h compacts were 8.02MPa and 2.62MPa, respectively, at 5h after mixing, and were 49.6MPa and 7.9MPa, respectively, at 2 weeks after mixing. All the CS and DTS values of the mβ-TCP-24h compacts were significantly higher than those of the control for the same duration after mixing. These results suggest that the mechano-chemically modified β-TCP powder dissolves rapidly and accelerates hydroxyapatite precipitation, which successfully shortens the cement setting time and enhances the strength. This study supports that mβ-TCP-24h is a promising candidate for use in injectable CPCs with improved strength.","ja":"Calcium phosphate cement (CPC) offers many advantages as a bone-substitution material. The objective of this study is to develop a new CPC that simultaneously exhibits fine injectability, a short setting time, and high strength. β-tricalcium phosphate (β-TCP, control) powder was ball-milled for 24h to produce a new cement powder. The modified β-TCP after 24h milling (mβ-TCP-24h) exhibited excellent injectability even 1h after mixing. The mechanical properties of the set cement (compact) were evaluated using compressive strength (CS) and diametral tensile strength (DTS) testing. The CS and DTS values of the mβ-TCP-24h compacts were 8.02MPa and 2.62MPa, respectively, at 5h after mixing, and were 49.6MPa and 7.9MPa, respectively, at 2 weeks after mixing. All the CS and DTS values of the mβ-TCP-24h compacts were significantly higher than those of the control for the same duration after mixing. These results suggest that the mechano-chemically modified β-TCP powder dissolves rapidly and accelerates hydroxyapatite precipitation, which successfully shortens the cement setting time and enhances the strength. This study supports that mβ-TCP-24h is a promising candidate for use in injectable CPCs with improved strength."},"publication_date":"2015-03-10","publication_name":{"en":"Journal of the Mechanical Behavior of Biomedical Materials","ja":"Journal of the Mechanical Behavior of Biomedical Materials"},"volume":"47","starting_page":"77","ending_page":"86","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.jmbbm.2015.03.005"],"issn":["1751-6161"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"1000242796","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/24787487","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=283755","label":"url"}],"paper_title":{"en":"Pim-2 kinase is an important target of treatment for tumor progression and bone loss in myeloma.","ja":"Pim-2 kinase is an important target of treatment for tumor progression and bone loss in myeloma."},"authors":{"en":[{"name":"Hiasa Masahiro"},{"name":"Teramachi Jumpei"},{"name":"Oda A"},{"name":"Amachi Ryota"},{"name":"Harada T"},{"name":"Nakamura Shingen"},{"name":"Miki Hirokazu"},{"name":"Fujii Shiroh"},{"name":"Kagawa Kumiko"},{"name":"Watanabe Keiichiro"},{"name":"Endo Itsuro"},{"name":"Kuroda Y"},{"name":"Yoneda T"},{"name":"Tsuji Daisuke"},{"name":"Nakao Michiyasu"},{"name":"Tanaka Eiji"},{"name":"Hamada Kenichi"},{"name":"Sano Shigeki"},{"name":"Itou Kouji"},{"name":"Matsumoto Toshio"},{"name":"Abe Masahiro"}],"ja":[{"name":"日浅 雅博"},{"name":"寺町 順平"},{"name":"Oda A"},{"name":"天知 良太"},{"name":"Harada T"},{"name":"中村 信元"},{"name":"三木 浩和"},{"name":"藤井 志朗"},{"name":"賀川 久美子"},{"name":"渡邉 佳一郎"},{"name":"遠藤 逸朗"},{"name":"Kuroda Y"},{"name":"Yoneda T"},{"name":"辻 大輔"},{"name":"中尾 允泰"},{"name":"田中 栄二"},{"name":"浜田 賢一"},{"name":"佐野 茂樹"},{"name":"伊藤 孝司"},{"name":"松本 俊夫"},{"name":"安倍 正博"}]},"description":{"en":"Pim-2 kinase is overexpressed in multiple myeloma (MM) cells to enhance their growth and survival, and regarded as a novel therapeutic target in MM. However, the impact of Pim-2 inhibition on bone disease in MM remains unknown. We demonstrated here that Pim-2 expression was also upregulated in bone marrow stromal cells and MC3T3-E1 preosteoblastic cells in the presence of cytokines known as the inhibitors of osteoblastogenesis in MM, including interleukin-3 (IL-3), IL-7, tumor necrosis factor-, transforming growth factor- (TGF-) and activin A, as well as MM cell conditioned media. The enforced expression of Pim-2 abrogated in vitro osteoblastogenesis by BMP-2, which suggested Pim-2 as a negative regulator for osteoblastogenesis. Treatment with Pim-2 short-interference RNA as well as the Pim inhibitor SMI-16a successfully restored osteoblastogenesis suppressed by all the above inhibitory factors and MM cells. The SMI-16a treatment potentiated BMP-2-mediated anabolic signaling while suppressing TGF- signaling. Furthermore, treatment with the newly synthesized thiazolidine-2,4-dione congener, 12a-OH, as well as its prototypic SMI-16a effectively prevented bone destruction while suppressing MM tumor growth in MM animal models. Thus, Pim-2 may have a pivotal role in tumor progression and bone loss in MM, and Pim-2 inhibition may become an important therapeutic strategy to target the MM cell-bone marrow interaction.Leukemia advance online publication, 30 May 2014; doi:10.1038/leu.2014.147.","ja":"Pim-2 kinase is overexpressed in multiple myeloma (MM) cells to enhance their growth and survival, and regarded as a novel therapeutic target in MM. However, the impact of Pim-2 inhibition on bone disease in MM remains unknown. We demonstrated here that Pim-2 expression was also upregulated in bone marrow stromal cells and MC3T3-E1 preosteoblastic cells in the presence of cytokines known as the inhibitors of osteoblastogenesis in MM, including interleukin-3 (IL-3), IL-7, tumor necrosis factor-, transforming growth factor- (TGF-) and activin A, as well as MM cell conditioned media. The enforced expression of Pim-2 abrogated in vitro osteoblastogenesis by BMP-2, which suggested Pim-2 as a negative regulator for osteoblastogenesis. Treatment with Pim-2 short-interference RNA as well as the Pim inhibitor SMI-16a successfully restored osteoblastogenesis suppressed by all the above inhibitory factors and MM cells. The SMI-16a treatment potentiated BMP-2-mediated anabolic signaling while suppressing TGF- signaling. Furthermore, treatment with the newly synthesized thiazolidine-2,4-dione congener, 12a-OH, as well as its prototypic SMI-16a effectively prevented bone destruction while suppressing MM tumor growth in MM animal models. Thus, Pim-2 may have a pivotal role in tumor progression and bone loss in MM, and Pim-2 inhibition may become an important therapeutic strategy to target the MM cell-bone marrow interaction.Leukemia advance online publication, 30 May 2014; doi:10.1038/leu.2014.147."},"publication_date":"2014-05-02","publication_name":{"en":"Leukemia","ja":"Leukemia"},"languages":["eng"],"referee":true,"identifiers":{"doi":["10.1038/leu.2014.147"],"issn":["1476-5551"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"1000242796","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/24090874","label":"url"},{"@id":"https://www.scopus.com/pages/publications/84884959362","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=272706","label":"url"}],"paper_title":{"en":"Fabrications of zinc-releasing biocement combining zinc calcium phosphate to calcium phosphate cement.","ja":"Fabrications of zinc-releasing biocement combining zinc calcium phosphate to calcium phosphate cement."},"authors":{"en":[{"name":"Horiuchi Shinya"},{"name":"Hiasa Masahiro"},{"name":"Yasue Akihiro"},{"name":"Sekine Kazumitsu"},{"name":"Hamada Kenichi"},{"name":"Asaoka Kenzo"},{"name":"Tanaka Eiji"}],"ja":[{"name":"堀内 信也"},{"name":"日浅 雅博"},{"name":"泰江 章博"},{"name":"関根 一光"},{"name":"浜田 賢一"},{"name":"淺岡 憲三"},{"name":"田中 栄二"}]},"description":{"en":"Recently, zinc-releasing bioceramics have been the focus of much attention owing to their bone-forming ability. Thus, some types of zinc-containing calcium phosphate (e.g., zinc-doped tricalcium phosphate and zinc-substituted hydroxyapatite) are examined and their osteoblastic cell responses determined. In this investigation, we studied the effects of zinc calcium phosphate (ZCP) derived from zinc phosphate incorporated into calcium phosphate cement (CPC) in terms of its setting reaction and MC3T3-E1 osteoblast-like cell responses. Compositional analysis by powder X-ray diffraction analysis revealed that HAP crystals were precipitated in the CPC containing 10 or 30wt% ZCP after successfully hardening. However, the crystal growth observed by scanning electron microscopy was delayed in the presence of additional ZCP. These findings indicate that the additional zinc inhibits crystal growth and the conversion of CPC to the HAP crystals. The proliferation of the cells and alkaline phosphatase (ALP) activity were enhanced when 10wt% ZCP was added to CPC. Taken together, ZCP added CPC at an appropriate fraction has a potent promotional effect on bone substitute biomaterials.","ja":"Recently, zinc-releasing bioceramics have been the focus of much attention owing to their bone-forming ability. Thus, some types of zinc-containing calcium phosphate (e.g., zinc-doped tricalcium phosphate and zinc-substituted hydroxyapatite) are examined and their osteoblastic cell responses determined. In this investigation, we studied the effects of zinc calcium phosphate (ZCP) derived from zinc phosphate incorporated into calcium phosphate cement (CPC) in terms of its setting reaction and MC3T3-E1 osteoblast-like cell responses. Compositional analysis by powder X-ray diffraction analysis revealed that HAP crystals were precipitated in the CPC containing 10 or 30wt% ZCP after successfully hardening. However, the crystal growth observed by scanning electron microscopy was delayed in the presence of additional ZCP. These findings indicate that the additional zinc inhibits crystal growth and the conversion of CPC to the HAP crystals. The proliferation of the cells and alkaline phosphatase (ALP) activity were enhanced when 10wt% ZCP was added to CPC. Taken together, ZCP added CPC at an appropriate fraction has a potent promotional effect on bone substitute biomaterials."},"publication_date":"2014-01","publication_name":{"en":"Journal of the Mechanical Behavior of Biomedical Materials","ja":"Journal of the Mechanical Behavior of Biomedical Materials"},"volume":"29C","starting_page":"151","ending_page":"160","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.jmbbm.2013.09.005"],"issn":["1878-0180"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"1000242796","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=280460","label":"url"}],"paper_title":{"en":"MRI対応生体内金属の開発","ja":"MRI対応生体内金属の開発"},"authors":{"en":[{"name":"Honda Eiichi"},{"name":"Hamada Kenichi"},{"name":"倉林 亨"},{"name":"Takegawa Emi"},{"name":"Yoshida Midori"}],"ja":[{"name":"誉田 栄一"},{"name":"浜田 賢一"},{"name":"倉林 亨"},{"name":"武川 恵美"},{"name":"吉田 みどり"}]},"publication_date":"2013-12-01","publication_name":{"en":"The Journal of the Japanese Society of Magnetic Applications in Dentistry","ja":"日本磁気歯科学会雑誌"},"volume":"22","number":"1","starting_page":"41","ending_page":"48","languages":["jpn"],"referee":true,"identifiers":{"issn":["0918-9629"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"1000242796","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=263721","label":"url"}],"paper_title":{"en":"Magnetic susceptibility and hardness of Au-xPt-yNb alloys for biomedical applications","ja":"Magnetic susceptibility and hardness of Au-xPt-yNb alloys for biomedical applications"},"authors":{"en":[{"name":"Takegawa Emi"},{"name":"Inui Shihoko"},{"name":"Hamada Kenichi"},{"name":"Honda Eiichi"},{"name":"Asaoka Kenzo"}],"ja":[{"name":"武川 恵美"},{"name":"乾 志帆子"},{"name":"浜田 賢一"},{"name":"誉田 栄一"},{"name":"淺岡 憲三"}]},"publication_date":"2013-08-13","publication_name":{"en":"Acta Biomaterialia","ja":"Acta Biomaterialia"},"volume":"9","starting_page":"8449","ending_page":"8453","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.actbio.2013.05.028"],"issn":["1742-7061"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"1000242796","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/24109823","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=283925","label":"url"}],"paper_title":{"en":"Evaluation of strontium introduced apatite cement as the injectable bone substitute developments.","ja":"Evaluation of strontium introduced apatite cement as the injectable bone substitute developments."},"authors":{"en":[{"name":"Sekine Kazumitsu"},{"name":"Sakama Minoru"},{"name":"Hamada Kenichi"}],"ja":[{"name":"関根 一光"},{"name":"阪間 稔"},{"name":"浜田 賢一"}]},"description":{"en":"We have developed bone cement introducing Strontium (Sr) to promote early bone regeneration. To prolong the release duration of Sr, we applied inorganic Sr filler for containing into the cement powder. The purpose of this study is to evaluate the mechanical properties, crystallinic properties, and ion release activities, especially Sr anion, of this cement. Alpha-TCP powder was mixed with Sr filler, with 0.1wt%, 0.5wt%, 1.0wt%, and 5.0wt%. These were mixed with mixing liquid and formed for each test. They were incubated and crystalized in 95% moisture for 1 week. The mechanical properties were studied by the compression, the diametral tensile strength and 4-point vending. Tested specimens were evaluated by X-ray diffraction(XRD) and scanning electron microscopic(SEM) imaging. The ion release behaviors were measured by inductively coupled plasma mass spectrometry(ICP-MS). The mechanical properties were increased in consistency of filler, but decreased in some samples because of declining the apatite matrix. And the Sr release showed interesting results as the sequential resource of Sr. By adjusting the mixing ratio or considering the application of these Sr releasable cements, this material would show good performance by its strength and longer Sr release for bone regeneration.","ja":"We have developed bone cement introducing Strontium (Sr) to promote early bone regeneration. To prolong the release duration of Sr, we applied inorganic Sr filler for containing into the cement powder. The purpose of this study is to evaluate the mechanical properties, crystallinic properties, and ion release activities, especially Sr anion, of this cement. Alpha-TCP powder was mixed with Sr filler, with 0.1wt%, 0.5wt%, 1.0wt%, and 5.0wt%. These were mixed with mixing liquid and formed for each test. They were incubated and crystalized in 95% moisture for 1 week. The mechanical properties were studied by the compression, the diametral tensile strength and 4-point vending. Tested specimens were evaluated by X-ray diffraction(XRD) and scanning electron microscopic(SEM) imaging. The ion release behaviors were measured by inductively coupled plasma mass spectrometry(ICP-MS). The mechanical properties were increased in consistency of filler, but decreased in some samples because of declining the apatite matrix. And the Sr release showed interesting results as the sequential resource of Sr. By adjusting the mixing ratio or considering the application of these Sr releasable cements, this material would show good performance by its strength and longer Sr release for bone regeneration."},"publication_date":"2013-07-26","publication_name":{"en":"Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society","ja":"Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society"},"volume":"2013 35th","starting_page":"858","ending_page":"861","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1109/EMBC.2013.6609636"],"issn":["1557-170X"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"1000242796","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/21751834","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=241851","label":"url"}],"paper_title":{"en":"Reinforcement of bond strength of self-etching orthodontic adhesive.","ja":"Reinforcement of bond strength of self-etching orthodontic adhesive."},"authors":{"en":[{"name":"Horiuchi Shinya"},{"name":"Kuroda Shingo"},{"name":"Hiasa Masahiro"},{"name":"Suge Toshiyuki"},{"name":"Saku Seitaro"},{"name":"Hamada Kenichi"},{"name":"Matsuo Takashi"},{"name":"Asaoka Kenzo"},{"name":"Tanaka Eiji"}],"ja":[{"name":"堀内 信也"},{"name":"黒田 晋吾"},{"name":"日浅 雅博"},{"name":"菅 俊行"},{"name":"Saku Seitaro"},{"name":"浜田 賢一"},{"name":"松尾 敬志"},{"name":"淺岡 憲三"},{"name":"田中 栄二"}]},"description":{"en":"Abstract Objective: To determine the reinforcement of bond strength of a self-etching system by applying a pretreatment agent. Materials and Methods: Sixty extracted human premolars were used in this study. The enamel surfaces were treated with four pretreatment agents?phosphoric acid, polyacrylic acid, citric acid, and ammonium hexafluorosilicate (SiF)?and were examined under a scanning electron microscope. Afterward, orthodontic brackets were bonded with a self-etching adhesive system (n ?=? 10 for each agent), and shear bond strength was measured through a debonding process. The adhesive remnant index (ARI) was also assessed. Results: Enamel surfaces treated with polyacrylic acid seemed almost the same as intact enamel. Treatment with SiF induced slight shallow depressions compared with the intact enamel. On the other hand, enamel surfaces treated with citric acid and phosphoric acid showed severe etching patterns. All pretreatments increased the bond strength, but SiF-treated specimens revealed the greatest strength (12.201 ? 1.048?MPa), followed by polyacrylic acid (12.030 ? 2.103?MPa). The control group with no pretreatment showed the least strength (9.078 ? 1.678?MPa). All pretreatments increased ARI score compared with the control group. Conclusions: Surface conditioning before bracket adhesion could reinforce the bond strength of the self-etching adhesive system, resulting in a more reliable bonding system.","ja":"Abstract Objective: To determine the reinforcement of bond strength of a self-etching system by applying a pretreatment agent. Materials and Methods: Sixty extracted human premolars were used in this study. The enamel surfaces were treated with four pretreatment agents?phosphoric acid, polyacrylic acid, citric acid, and ammonium hexafluorosilicate (SiF)?and were examined under a scanning electron microscope. Afterward, orthodontic brackets were bonded with a self-etching adhesive system (n ?=? 10 for each agent), and shear bond strength was measured through a debonding process. The adhesive remnant index (ARI) was also assessed. Results: Enamel surfaces treated with polyacrylic acid seemed almost the same as intact enamel. Treatment with SiF induced slight shallow depressions compared with the intact enamel. On the other hand, enamel surfaces treated with citric acid and phosphoric acid showed severe etching patterns. All pretreatments increased the bond strength, but SiF-treated specimens revealed the greatest strength (12.201 ? 1.048?MPa), followed by polyacrylic acid (12.030 ? 2.103?MPa). The control group with no pretreatment showed the least strength (9.078 ? 1.678?MPa). All pretreatments increased ARI score compared with the control group. Conclusions: Surface conditioning before bracket adhesion could reinforce the bond strength of the self-etching adhesive system, resulting in a more reliable bonding system."},"publication_date":"2011-07-13","publication_name":{"en":"The Angle Orthodontist","ja":"The Angle Orthodontist"},"volume":"82","number":"1","starting_page":"30","ending_page":"35","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2319/012011-39.1"],"issn":["1945-7103"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"1000242796","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/20379030","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=209315","label":"url"}],"paper_title":{"en":"Antibacterial activity of composite resin with glass-ionomer filler particles","ja":"Antibacterial activity of composite resin with glass-ionomer filler particles"},"authors":{"en":[{"name":"Saku Seitaro"},{"name":"Kotake Hirotomo"},{"name":"Scougall Vilchis RJ"},{"name":"Ohashi Shizue"},{"name":"Hotta Masato"},{"name":"Horiuchi Shinya"},{"name":"Hamada Kenichi"},{"name":"Asaoka Kenzo"},{"name":"Tanaka Eiji"},{"name":"Yamamoto Kohji"}],"ja":[{"name":"Saku Seitaro"},{"name":"Kotake Hirotomo"},{"name":"Scougall Vilchis RJ"},{"name":"Ohashi Shizue"},{"name":"Hotta Masato"},{"name":"堀内 信也"},{"name":"浜田 賢一"},{"name":"淺岡 憲三"},{"name":"田中 栄二"},{"name":"Yamamoto Kohji"}]},"description":{"en":"The purpose of this study was to examine the antibacterial activity of composite resin with glass-ionomer filler particles versus that of contemporary commercial composite resins. Three composite resins were used: Beautifil II (containing S-PRG filler), Clearfil AP-X, and Filtek Z250. Resin blocks were bonded to maxillary first molars, and plaque accumulation on the resin block surface was examined after 8 hours. For the antibacterial test, the number of Streptococcus mutans in contact with the composite resin blocks after incubation for 12 hours was determined, and adherence of radiolabeled bacteria was evaluated. Less dental plaque was formed on Beautifil II resin block as compared to the other two materials. Antibacterial test revealed that there were no significant differences in the number of Streptococcus mutans among the three composite resins. However, the adherence of radiolabeled bacteria to the saliva-treated resin surface was significantly (p>0.01) lower in Beautifil II than in the other two materials. These results suggested that Beautifil II could reduce dental plaque formation and bacterial adherence, leading to prevention of secondary caries","ja":"The purpose of this study was to examine the antibacterial activity of composite resin with glass-ionomer filler particles versus that of contemporary commercial composite resins. Three composite resins were used: Beautifil II (containing S-PRG filler), Clearfil AP-X, and Filtek Z250. Resin blocks were bonded to maxillary first molars, and plaque accumulation on the resin block surface was examined after 8 hours. For the antibacterial test, the number of Streptococcus mutans in contact with the composite resin blocks after incubation for 12 hours was determined, and adherence of radiolabeled bacteria was evaluated. Less dental plaque was formed on Beautifil II resin block as compared to the other two materials. Antibacterial test revealed that there were no significant differences in the number of Streptococcus mutans among the three composite resins. However, the adherence of radiolabeled bacteria to the saliva-treated resin surface was significantly (p>0.01) lower in Beautifil II than in the other two materials. These results suggested that Beautifil II could reduce dental plaque formation and bacterial adherence, leading to prevention of secondary caries"},"publication_date":"2010-03","publication_name":{"en":"Dental Materials Journal","ja":"Dental Materials Journal"},"volume":"29","number":"2","starting_page":"193","ending_page":"198","languages":["eng"],"referee":true,"identifiers":{"doi":["10.4012/dmj.2009-050"],"issn":["0287-4547"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"1000242796","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/19721278","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=193614","label":"url"}],"paper_title":{"en":"Enamel bonding of self-etching and phosphoric acid-etching orthodontic adhesives in simulated clinical conditions: Debonding force and enamel surface","ja":"Enamel bonding of self-etching and phosphoric acid-etching orthodontic adhesives in simulated clinical conditions: Debonding force and enamel surface"},"authors":{"en":[{"name":"Horiuchi Shinya"},{"name":"Kaneko Kazuyuki"},{"name":"Mori H"},{"name":"Kawakami Emi"},{"name":"Tsukahara T"},{"name":"Yamamoto K"},{"name":"Hamada Kenichi"},{"name":"Asaoka Kenzo"},{"name":"Tanaka Eiji"}],"ja":[{"name":"堀内 信也"},{"name":"金子 和之"},{"name":"Mori H"},{"name":"川上 恵実"},{"name":"Tsukahara T"},{"name":"Yamamoto K"},{"name":"浜田 賢一"},{"name":"淺岡 憲三"},{"name":"田中 栄二"}]},"description":{"en":"This study aimed to evaluate the effectiveness of self-etching and phosphoric acid-etching orthodontic adhesives for enamel bonding in simulated clinical conditions. By using two self-etching (Transbond Plus, TP; Beauty Ortho Bond, BB) and two acid-etching (Transbond XT, TX; Superbond Orthomite, SB) adhesives, orthodontic brackets were bonded on human premolars (n=10 for each adhesive). Ten teeth without bracket bonding, i.e., intact enamel surfaces, were used as control for SEM observation. After 7-day storage in lactic acid solution, bracket debonding force by means of debonding pliers, adhesive remnant index (ARI), and enamel surface morphology were examined. All the tested adhesives exhibited sufficient bond strength for clinical use. The ARI scores were almost the same among the four adhesives. In terms of SEM observation, the enamel surfaces in the control and TP groups showed a slight change after immersion in lactic acid solution, while the BB group showed less change on the enamel surface compared with the TP group. Meanwhile, the two acid-etching adhesives caused considerable demineralization. Taken together, these findings indicated that the action of self-etching systems was evidently more conservative.","ja":"This study aimed to evaluate the effectiveness of self-etching and phosphoric acid-etching orthodontic adhesives for enamel bonding in simulated clinical conditions. By using two self-etching (Transbond Plus, TP; Beauty Ortho Bond, BB) and two acid-etching (Transbond XT, TX; Superbond Orthomite, SB) adhesives, orthodontic brackets were bonded on human premolars (n=10 for each adhesive). Ten teeth without bracket bonding, i.e., intact enamel surfaces, were used as control for SEM observation. After 7-day storage in lactic acid solution, bracket debonding force by means of debonding pliers, adhesive remnant index (ARI), and enamel surface morphology were examined. All the tested adhesives exhibited sufficient bond strength for clinical use. The ARI scores were almost the same among the four adhesives. In terms of SEM observation, the enamel surfaces in the control and TP groups showed a slight change after immersion in lactic acid solution, while the BB group showed less change on the enamel surface compared with the TP group. Meanwhile, the two acid-etching adhesives caused considerable demineralization. Taken together, these findings indicated that the action of self-etching systems was evidently more conservative."},"publication_date":"2009-07","publication_name":{"en":"Dental Materials Journal","ja":"Dental Materials Journal"},"volume":"28","number":"4","starting_page":"419","ending_page":"425","languages":["eng"],"referee":true,"identifiers":{"doi":["10.4012/dmj.28.419"],"issn":["0287-4547"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"1000242796","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/19581714","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=193529","label":"url"}],"paper_title":{"en":"Effects of heat treatment on the bioactivity of surface-modified titanium in calcium solution","ja":"Effects of heat treatment on the bioactivity of surface-modified titanium in calcium solution"},"authors":{"en":[{"name":"Sultana Razia"},{"name":"Hamada Kenichi"},{"name":"Ichikawa Tetsuo"},{"name":"Asaoka Kenzo"}],"ja":[{"name":"Sultana Razia"},{"name":"浜田 賢一"},{"name":"市川 哲雄"},{"name":"淺岡 憲三"}]},"description":{"en":"The purpose of this study was to determine the effects of heat treatment on the bioactivity of hydrothermal-modified titanium in CaO solution for improved bioactivity by immersion in simulated body fluid (SBF). The hydrothermal treatment of titanium in CaO solution was performed at 121 degrees C at 0.2 MPa for 1 h in an autoclave followed by 1 h heat treatments at 200, 400, 600 and 800 degrees C simultaneously. The bioactivity of titanium was evaluated by hydroxyapatite precipitation during immersion in SBF. Surface microstructure changes after the heat treatments and immersion in SBF were determined by X-ray diffractometry (XRD), X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM). Heat treatments at high temperatures (600 and 800 degrees C) promoted the synthesis of anatase, increased the thickness of the titanium oxide layer on the modified titanium surface and promoted the synthesis of calcium titanate, which possibly promoted the precipitation of apatite in SBF. The extent of precipitations increased with the time of immersion in SBF and the temperature of the heat treatment. Island-like deposits of needle-like crystals were observed only on the surface of the 600 and 800 degrees C heat-treated specimens after two or four week immersions in SBF. The results suggested that treatments of the surface of hydrothermal-treated titanium specimens at high temperatures (600 and 800 degrees C) could be effective for the surface modification of titanium as an implant material offering better osseointegration.","ja":"The purpose of this study was to determine the effects of heat treatment on the bioactivity of hydrothermal-modified titanium in CaO solution for improved bioactivity by immersion in simulated body fluid (SBF). The hydrothermal treatment of titanium in CaO solution was performed at 121 degrees C at 0.2 MPa for 1 h in an autoclave followed by 1 h heat treatments at 200, 400, 600 and 800 degrees C simultaneously. The bioactivity of titanium was evaluated by hydroxyapatite precipitation during immersion in SBF. Surface microstructure changes after the heat treatments and immersion in SBF were determined by X-ray diffractometry (XRD), X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM). Heat treatments at high temperatures (600 and 800 degrees C) promoted the synthesis of anatase, increased the thickness of the titanium oxide layer on the modified titanium surface and promoted the synthesis of calcium titanate, which possibly promoted the precipitation of apatite in SBF. The extent of precipitations increased with the time of immersion in SBF and the temperature of the heat treatment. Island-like deposits of needle-like crystals were observed only on the surface of the 600 and 800 degrees C heat-treated specimens after two or four week immersions in SBF. The results suggested that treatments of the surface of hydrothermal-treated titanium specimens at high temperatures (600 and 800 degrees C) could be effective for the surface modification of titanium as an implant material offering better osseointegration."},"publication_date":"2009-07","publication_name":{"en":"Bio-Medical Materials and Engineering","ja":"Bio-Medical Materials and Engineering"},"volume":"19","number":"2-3","starting_page":"193","ending_page":"204","languages":["eng"],"referee":true,"identifiers":{"doi":["10.3233/BME-2008-0580"],"issn":["0959-2989"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"1000242796","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=148045","label":"url"}],"paper_title":{"en":"Effects of ternary additions on martensitic transformation of TiAu","ja":"Effects of ternary additions on martensitic transformation of TiAu"},"authors":{"en":[{"name":"Kawamura, T."},{"name":"Tachi, R."},{"name":"Inamura, T."},{"name":"Hosoda, H."},{"name":"Wakashima, K."},{"name":"Hamada Kenichi"},{"name":"Miyazaki, S."}],"ja":[{"name":"Kawamura, T."},{"name":"Tachi, R."},{"name":"Inamura, T."},{"name":"Hosoda, H."},{"name":"Wakashima, K."},{"name":"浜田 賢一"},{"name":"Miyazaki, S."}]},"publication_date":"2006-11","publication_name":{"en":"Materials Science and Engineering A","ja":"Materials Science and Engineering A"},"volume":"438-440","starting_page":"383","ending_page":"386","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.msea.2006.01.123"],"issn":["0921-5093"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"1000242796","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"http://ci.nii.ac.jp/naid/40006892626/","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1520009409490024320/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=126446","label":"url"}],"paper_title":{"en":"TiNi形状記憶合金ワイヤ強化Mg合金基複合材料の組織と機械的性質","ja":"TiNi形状記憶合金ワイヤ強化Mg合金基複合材料の組織と機械的性質"},"authors":{"en":[{"name":"水内 潔"},{"name":"井上 漢龍"},{"name":"杉岡 正美"},{"name":"伊丹 正郎"},{"name":"Hamada Kenichi"},{"name":"川原 正和"}],"ja":[{"name":"水内 潔"},{"name":"井上 漢龍"},{"name":"杉岡 正美"},{"name":"伊丹 正郎"},{"name":"浜田 賢一"},{"name":"川原 正和"}]},"publication_date":"2005-08-01","publication_name":{"en":"Journal of the Japan Institute Metals","ja":"日本金属学会誌"},"volume":"69","number":"8","starting_page":"608","ending_page":"613","languages":["jpn"],"referee":true,"identifiers":{"doi":["10.2320/jinstmet.69.608"],"issn":["0021-4876"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"1000242796","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://cir.nii.ac.jp/crid/1570291226806903424/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=126447","label":"url"}],"paper_title":{"en":"Processing of TiNi SMA fiber reinforced AZ31 Mg alloy matrix composite by pulsed current hot pressing","ja":"Processing of TiNi SMA fiber reinforced AZ31 Mg alloy matrix composite by pulsed current hot pressing"},"authors":{"en":[{"name":"Mizuuchi Kiyoshi"},{"name":"Inoue Kanryu"},{"name":"Hamada Kenichi"},{"name":"Sugioka Masami"},{"name":"Itami Masao"},{"name":"Fukusumi M"},{"name":"Kawahara M"}],"ja":[{"name":"Mizuuchi Kiyoshi"},{"name":"Inoue Kanryu"},{"name":"浜田 賢一"},{"name":"Sugioka Masami"},{"name":"Itami Masao"},{"name":"Fukusumi M"},{"name":"Kawahara M"}]},"publication_date":"2004-01-01","publication_name":{"en":"Materials Science and Engineering A","ja":"Materials Science and Engineering A"},"volume":"367","number":"1-2","starting_page":"343","ending_page":"349","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.msea.2003.10.286"],"issn":["0921-5093"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"1000242796","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/12873119","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1390001204717659136/","label":"url"},{"@id":"https://www.scopus.com/pages/publications/0141448733","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=78626","label":"url"}],"paper_title":{"en":"Shape recovery of shape memory alloy fiber embedded resin matrix smart composite after crack repair","ja":"Shape recovery of shape memory alloy fiber embedded resin matrix smart composite after crack repair"},"authors":{"en":[{"name":"Hamada Kenichi"},{"name":"Kawano Fumiaki"},{"name":"Asaoka Kenzo"}],"ja":[{"name":"浜田 賢一"},{"name":"河野 文昭"},{"name":"淺岡 憲三"}]},"description":{"en":"Ni-Ti shape memory alloy fiber embedded resin matrix composites were produced for evaluation of \"smart denture\", a newly developing denture with the function to close its own crack. Their bending strength and shape recovery after instant crack repair was estimated. The embedded fibers did not decrease the bending strength of the composite after repair. The crack closure of the composites was performed well simply by heating at 80 degrees C. Nevertheless, they showed apparent deflection after crack repair. The following two phenomena were supposed to be the main cause of it: the polymerization shrinkage of matrix resin with heating, and the coefficient of the thermal expansion mismatch between the fiber and the matrix. The embedded fibers could close the crack of the matrix with enough high accuracy for specimen repair, but they turned out to change the specimen shape after repair.","ja":"Ni-Ti shape memory alloy fiber embedded resin matrix composites were produced for evaluation of \"smart denture\", a newly developing denture with the function to close its own crack. Their bending strength and shape recovery after instant crack repair was estimated. The embedded fibers did not decrease the bending strength of the composite after repair. The crack closure of the composites was performed well simply by heating at 80 degrees C. Nevertheless, they showed apparent deflection after crack repair. The following two phenomena were supposed to be the main cause of it: the polymerization shrinkage of matrix resin with heating, and the coefficient of the thermal expansion mismatch between the fiber and the matrix. The embedded fibers could close the crack of the matrix with enough high accuracy for specimen repair, but they turned out to change the specimen shape after repair."},"publication_date":"2003-06","publication_name":{"en":"Dental Materials Journal","ja":"Dental Materials Journal"},"volume":"22","number":"2","starting_page":"160","ending_page":"167","languages":["eng"],"referee":true,"identifiers":{"doi":["10.4012/dmj.22.160"],"issn":["0287-4547"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"1000242796","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"http://ci.nii.ac.jp/naid/80015660462/","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1572543026611475328/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=93552","label":"url"}],"paper_title":{"en":"Susceptability to delayed fracture of Ni-Ti superelastic alloy","ja":"Susceptability to delayed fracture of Ni-Ti superelastic alloy"},"authors":{"en":[{"name":"Yokoyama Ken'ichi"},{"name":"Watabe Shyozo"},{"name":"Hamada Kenichi"},{"name":"Sakai Jun'ichi"},{"name":"Asaoka Kenzo"},{"name":"Nagumo Michihiko"}],"ja":[{"name":"横山 賢一"},{"name":"Watabe Shyozo"},{"name":"浜田 賢一"},{"name":"Sakai Jun'ichi"},{"name":"淺岡 憲三"},{"name":"Nagumo Michihiko"}]},"publication_date":"2003","publication_name":{"en":"Materials Science and Engineering A","ja":"Materials Science and Engineering A"},"volume":"341","number":"1-2","starting_page":"91","ending_page":"97","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/S0921-5093(02)00201-0"],"issn":["0921-5093"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"1000242796","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=126448","label":"url"}],"paper_title":{"en":"Thermomechanical Behavior of Ti-25Pd-24Ni-1W Shape Memory Ally Reinforced Ti Matrix Smart Composites","ja":"Thermomechanical Behavior of Ti-25Pd-24Ni-1W Shape Memory Ally Reinforced Ti Matrix Smart Composites"},"authors":{"en":[{"name":"Mizuuchi Kiyoshi"},{"name":"Inoue Kanryu"},{"name":"Hamada Kenichi"},{"name":"Yamauchi Kiyoshi"},{"name":"Enami Kazuyuki"},{"name":"Sugioka Masami"},{"name":"Itami Masao"},{"name":"Okanda Yoshihira"}],"ja":[{"name":"Mizuuchi Kiyoshi"},{"name":"Inoue Kanryu"},{"name":"浜田 賢一"},{"name":"Yamauchi Kiyoshi"},{"name":"Enami Kazuyuki"},{"name":"Sugioka Masami"},{"name":"Itami Masao"},{"name":"Okanda Yoshihira"}]},"publication_date":"2002-06","publication_name":{"en":"Materials Science and Engineering A","ja":"Materials Science and Engineering A"},"volume":"329-331","starting_page":"557","ending_page":"562","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/S0921-5093(01)01563-5"],"issn":["0921-5093"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
{"insert":{"user_id":"1000242796","type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/11962668","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=71188","label":"url"}],"paper_title":{"en":"Hydrothermal modification of titanium surface in calcium solutions","ja":"Hydrothermal modification of titanium surface in calcium solutions"},"authors":{"en":[{"name":"Hamada Kenichi"},{"name":"Kon Masayuki"},{"name":"Hanawa Takao"},{"name":"Yokoyama Ken'ichi"},{"name":"Miyamoto Youji"},{"name":"Asaoka Kenzo"}],"ja":[{"name":"浜田 賢一"},{"name":"今 政幸"},{"name":"塙 隆夫"},{"name":"横山 賢一"},{"name":"宮本 洋二"},{"name":"淺岡 憲三"}]},"description":{"en":"Hydrothermal modification of a titanium surface in calcium solutions was performed. The apatite precipitation on the modified surface in Hanks' solution, as a simulated body fluid, was evaluated and the surface microstructure changes after the modification were characterized by thin-film X-ray diffractometry (TF-XRD) and X-ray photoelectron spectroscopy (XPS). Hydrothermal modification in CaO solution enhanced the precipitation of apatite on the titanium surface. High pH, high pressure and high temperature of the CaO solution increased the thickness of the surface-modified layer and enhanced the synthesis of calcium titanate which possibly promoted the precipitation of apatite in Hanks' solution. Hydrothermal modification in CaCl2 solution, on the other hand, showed reverse effects. The modification of titanium in CaO solution with hydrothermal treatment is expected to result in excellent osteointegration and can be easily performed by using an autoclave, a clinical apparatus widely used.","ja":"Hydrothermal modification of a titanium surface in calcium solutions was performed. The apatite precipitation on the modified surface in Hanks' solution, as a simulated body fluid, was evaluated and the surface microstructure changes after the modification were characterized by thin-film X-ray diffractometry (TF-XRD) and X-ray photoelectron spectroscopy (XPS). Hydrothermal modification in CaO solution enhanced the precipitation of apatite on the titanium surface. High pH, high pressure and high temperature of the CaO solution increased the thickness of the surface-modified layer and enhanced the synthesis of calcium titanate which possibly promoted the precipitation of apatite in Hanks' solution. Hydrothermal modification in CaCl2 solution, on the other hand, showed reverse effects. The modification of titanium in CaO solution with hydrothermal treatment is expected to result in excellent osteointegration and can be easily performed by using an autoclave, a clinical apparatus widely used."},"publication_date":"2002-05","publication_name":{"en":"Biomaterials","ja":"Biomaterials"},"volume":"23","number":"10","starting_page":"2265","ending_page":"2272","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/S0142-9612(01)00361-1"],"issn":["0142-9612"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
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