published_papers "タイトル(日本語)","タイトル(英語)","著者(日本語)","著者(英語)","担当区分","概要(日本語)","概要(英語)","出版者・発行元(日本語)","出版者・発行元(英語)","出版年月","誌名(日本語)","誌名(英語)","巻","号","開始ページ","終了ページ","記述言語","査読の有無","招待の有無","掲載種別","国際・国内誌","国際共著","DOI","ISSN","eISSN","URL","URL2","主要な業績かどうか","公開の有無" "歯科口腔外科手術における高齢患者の麻酔方法と術前合併疾患に関する検討","歯科口腔外科手術における高齢患者の麻酔方法と術前合併疾患に関する検討","西川 美佳, 高石 和美, 藤原 茂樹, 江口 覚, 北畑 洋, 川人 伸次","西川 美佳, Kazumi Takaishi, Shigeki Fujiwara Joseph Luke, Satoru Eguchi, Hiroshi Kitahata, Shinji Kawahito","null","null","null","null","null","2024-01","臨床麻酔","臨床麻酔","Vol.48","No.1","87","89","jpn","true","null","scientific_journal","null","null","null","null","null","null","null","null","null" "Pronounced QTc Prolongation During General Anesthesia in a Child with Left Ventricular Non-Compaction Cardiomyopathy","Pronounced QTc Prolongation During General Anesthesia in a Child with Left Ventricular Non-Compaction Cardiomyopathy","Nishikawa Mika, Kazumi Takaishi, Takata Marina, Sasajima Osamu, Shigeki Fujiwara Joseph Luke, Satoru Eguchi, Shinji Kawahito","Nishikawa Mika, Kazumi Takaishi, Takata Marina, Sasajima Osamu, Shigeki Fujiwara Joseph Luke, Satoru Eguchi, Shinji Kawahito","null","null","null","null","null","2023-09-01","Anesthesia Progress","Anesthesia Progress","Vol.70","No.3","137","139","eng","true","null","scientific_journal","null","null","null","null","null","null","null","null","null" "機器紹介 インターサージカル個人防護用呼吸マスク「i-Proマスク」","機器紹介 インターサージカル個人防護用呼吸マスク「i-Proマスク」","西川 美佳, 高田 真里菜, 篠島 理, 髙田 香, 藤原 茂樹, 江口 覚, 高石 和美, 川人 伸次","西川 美佳, 高田 真里菜, 篠島 理, Kaori Takata, Shigeki Fujiwara Joseph Luke, Satoru Eguchi, Kazumi Takaishi, Shinji Kawahito","null","null","null","null","null","2022-12","循環制御","Circulation Control","Vol.43","No.2","107-108","107-108","jpn","true","true","scientific_journal","null","null","null","0389-1844","null","null","null","null","null" "複数回の再手術を要し血友病Bと判明した舌裂傷の1症例","複数回の再手術を要し血友病Bと判明した舌裂傷の1症例","高田 真里菜, 篠島 理, 西川 美佳, 髙田 香, 藤原 茂樹, 江口 覚, 高石 和美, 箕田 直治, 曽我 朋宏, 木下 浩之, 川人 伸次","高田 真里菜, 篠島 理, 西川 美佳, Kaori Takata, Shigeki Fujiwara Joseph Luke, Satoru Eguchi, Kazumi Takaishi, Naoji Mita, Tomohiro Soga, 木下 浩之, Shinji Kawahito","null","null","null","null","null","2022-10","日本小児麻酔学会誌","Clinical Pediatric Anesthesia","Vol.28","No.1","59-61","59-61","jpn","true","null","scientific_journal","null","null","null","1341-5603","null","null","null","null","null" "下咽頭梨状窩瘻に対しトリクロル酢酸で化学的焼灼術を施行した1症例","下咽頭梨状窩瘻に対しトリクロル酢酸で化学的焼灼術を施行した1症例","篠島 理, 高田 真里菜, 西川 美佳, 髙田 香, 藤原 茂樹, 江口 覚, 高石 和美, 箕田 直治, 曽我 朋宏, 木下 浩之, 川人 伸次","篠島 理, 高田 真里菜, 西川 美佳, Kaori Takata, Shigeki Fujiwara Joseph Luke, Satoru Eguchi, Kazumi Takaishi, Naoji Mita, Tomohiro Soga, 木下 浩之, Shinji Kawahito","null","null","null","null","null","2022-10","日本小児麻酔学会誌","Clinical Pediatric Anesthesia","Vol.29","No.1","62-64","62-64","jpn","true","null","scientific_journal","null","null","null","1341-5603","null","null","null","null","null" "Total Intravenous Anesthesia Using Remimazolam and Continuous Cardiac Output Monitoring for Dental Anesthesia in a Patient With Takayasus Arteritis: A Case Report","Total Intravenous Anesthesia Using Remimazolam and Continuous Cardiac Output Monitoring for Dental Anesthesia in a Patient With Takayasus Arteritis: A Case Report","Kazumi Takaishi, Marina Takata, Risa Aoki, Shigeki Fujiwara Joseph Luke, Shinji Kawahito, Hiroshi Kitahata","Kazumi Takaishi, Marina Takata, Risa Aoki, Shigeki Fujiwara Joseph Luke, Shinji Kawahito, Hiroshi Kitahata","null","Takayasu's arteritis is a persistent chronic progressive inflammation of the large- and medium-caliber arteries. Controlling cardiovascular variability during anesthesia and overcoming difficulties of cardiovascular monitoring due to the impaired vessels are important in patients with Takayasu's arteritis. Remimazolam is a novel short-acting benzodiazepine with mild effects on hemodynamics. We report the case of a patient with Takayasu's arteritis who underwent oral surgery under general anesthesia. This report highlights the use of remimazolam and remifentanil to reduce hemodynamic perturbations using estimated continuous cardiac output monitoring.","Takayasu's arteritis is a persistent chronic progressive inflammation of the large- and medium-caliber arteries. Controlling cardiovascular variability during anesthesia and overcoming difficulties of cardiovascular monitoring due to the impaired vessels are important in patients with Takayasu's arteritis. Remimazolam is a novel short-acting benzodiazepine with mild effects on hemodynamics. We report the case of a patient with Takayasu's arteritis who underwent oral surgery under general anesthesia. This report highlights the use of remimazolam and remifentanil to reduce hemodynamic perturbations using estimated continuous cardiac output monitoring.","null","null","2022-08-09","A&A Practice","A&A Practice","Vol.16","No.8","e01599","e01599","eng","true","null","scientific_journal","null","null","10.1213/XAA.0000000000001599","2575-3126","null","null","null","null","null" "全身麻酔導入および覚醒時に顕著なQTc延長を認めた左室心筋緻密化障害患児の1例","全身麻酔導入および覚醒時に顕著なQTc延長を認めた左室心筋緻密化障害患児の1例","西川 美佳, 高石 和美, 髙田 真里菜, 篠島 理, 藤原 茂樹, 江口 覚, 川人 伸次","西川 美佳, Kazumi Takaishi, 髙田 真里菜, 篠島 理, Shigeki Fujiwara Joseph Luke, Satoru Eguchi, Shinji Kawahito","null","null","null","null","null","2022-04-15","日本歯科麻酔学会雑誌","Journal of Japanese Dental Society of Anesthesiology","Vol.50","No.2","70","72","jpn","true","null","scientific_journal","null","null","null","0386-5835","null","null","null","null","null" "静脈内鎮静法と舌神経ブロックで管理した 妊娠初期患者の舌腫瘍切除術の 1 例","Successful Anesthesia Management of a First-trimester Pregnant Patient Requiring Oral Malignancy Ablative Surgery Using Intravenous Sedation and a Lingual Nerve Block : A Case Report","青木 理紗, 月本 翔太, 永野 沙紀, 湯浅 あかね, 高石 和美, 高杉 嘉弘","青木 理紗, 月本 翔太, 永野 沙紀, 湯浅 あかね, Kazumi Takaishi, 高杉 嘉弘","null","null","null","null","null","2022-03-15","日本歯科麻酔学会雑誌","Journal of Japanese Dental Society of Anesthesiology","Vol.50","No.3","131","133","jpn","true","null","scientific_journal","null","null","10.24569/jjdsa.50.3_131","2433-4480","null","https://search.jamas.or.jp/link/ui/2022282785","null","null","null" "心肺蘇生教育に用いる気道管理シミュレータ4種類の気管挿管手技における比較","心肺蘇生教育に用いる気道管理シミュレータ4種類の気管挿管手技における比較","青木 理紗, 高石 和美, 西川 美佳, 藤原 茂樹, 長宗 雅美, 赤池 雅史, 河野 文昭, 川人 伸次","青木 理紗, Kazumi Takaishi, 西川 美佳, Shigeki Fujiwara Joseph Luke, Masami Nagamune, Masashi Akaike, Fumiaki Kawano, Shinji Kawahito","null","null","null","null","null","2022-03-10","日本歯科医学教育学会雑誌","The Journal of Japanese Dental Education Association","Vol.38","No.1","63","68","jpn","true","null","scientific_journal","null","null","null","0914-5133","null","null","null","null","null" "全身麻酔導入および覚醒時に顕著なQTc延長を認めた左室心筋緻密化障害患児の1例","Pronounced QTc Prolongation during Induction of and Awakening from General Anesthesia in a Child with Left Ventricular Non-compaction Cardiomyopathy : A Case Report","西川 美佳, 高石 和美, 高田 真里菜, 篠島 理, 藤原 茂樹, 江口 覚, 川人 伸次","西川 美佳, Kazumi Takaishi, 高田 真里菜, 篠島 理, Shigeki Fujiwara Joseph Luke, Satoru Eguchi, Shinji Kawahito","null","null","null","null","null","2022-02-09","日本歯科麻酔学会雑誌","Journal of Japanese Dental Society of Anesthesiology","Vol.50","No.2","70","72","jpn","true","null","scientific_journal","null","null","10.24569/jjdsa.50.2_70","2433-4480","null","https://search.jamas.or.jp/link/ui/2022255991","null","null","null" "Management of a patient with tracheal stenosis after previous tracheotomy","Management of a patient with tracheal stenosis after previous tracheotomy","Kazumi Takaishi, Shinji Kawahito, Hiroshi Kitahata","Kazumi Takaishi, Shinji Kawahito, Hiroshi Kitahata","null","Tracheal stenosis after tracheotomy can cause difficult airway management and respiratory complications. It is difficult to predict tracheal stenosis after tracheotomy based on a patient's symptoms as the symptoms of tracheal stenosis appear only after they become severe. In patients with a history of previous tracheotomy, it is important to consider the risk factors for tracheal stenosis. Detailed preoperative evaluation of patients with a history of previous tracheotomy is essential and should include 3-dimensional assessment of the airway. We report the preoperative assessment and perioperative management of an 83-year-old woman at high risk for tracheal stenosis due to a previous emergency tracheotomy who was scheduled to undergo general anesthesia for a right maxillectomy for squamous cell carcinoma. Preoperative anteroposterior chest radiograph revealed findings indicative of tracheal stenosis. Additional detailed examinations of the stenotic area were conducted with computed tomography imaging and bronchofiberscopy. General anesthesia with nasotracheal intubation was performed, and although there were no adverse intraoperative events, stridor after extubation was observed. Nebulized epinephrine was administered via an ultrasound nebulizer and effectively improved the patient's postoperative transient dyspnea.","Tracheal stenosis after tracheotomy can cause difficult airway management and respiratory complications. It is difficult to predict tracheal stenosis after tracheotomy based on a patient's symptoms as the symptoms of tracheal stenosis appear only after they become severe. In patients with a history of previous tracheotomy, it is important to consider the risk factors for tracheal stenosis. Detailed preoperative evaluation of patients with a history of previous tracheotomy is essential and should include 3-dimensional assessment of the airway. We report the preoperative assessment and perioperative management of an 83-year-old woman at high risk for tracheal stenosis due to a previous emergency tracheotomy who was scheduled to undergo general anesthesia for a right maxillectomy for squamous cell carcinoma. Preoperative anteroposterior chest radiograph revealed findings indicative of tracheal stenosis. Additional detailed examinations of the stenotic area were conducted with computed tomography imaging and bronchofiberscopy. General anesthesia with nasotracheal intubation was performed, and although there were no adverse intraoperative events, stridor after extubation was observed. Nebulized epinephrine was administered via an ultrasound nebulizer and effectively improved the patient's postoperative transient dyspnea.","null","null","2021-12-15","Anesthesia Progress","Anesthesia Progress","Vol.68","No.4","224","229","eng","true","null","scientific_journal","null","null","10.2344/anpr-68-03-08","1878-7177","null","null","null","null","null" "細胞骨格およびIL-17制御を介した血管内皮機能維持機構の解明と麻酔薬作用","細胞骨格およびIL-17制御を介した血管内皮機能維持機構の解明と麻酔薬作用","川人 伸次, 高石 和美, 江口 覚, 藤原 茂樹, 西川 美佳, 髙田 真里菜, 篠島 理, 木下 浩之","Shinji Kawahito, Kazumi Takaishi, Satoru Eguchi, Shigeki Fujiwara Joseph Luke, 西川 美佳, 髙田 真里菜, 篠島 理, 木下 浩之","null","null","null","null","null","2021-11","BIO Clinica","BIO Clinica","Vol.36","No.12","68","71","jpn","true","null","scientific_journal","null","null","null","0919-8237","null","https://search.jamas.or.jp/link/ui/2022004914","null","null","null" "Viability of intensive insulin therapy during pediatric surgery","Viability of intensive insulin therapy during pediatric surgery","Tomohiro Soga, Shinji Kawahito, Naoji Mita, Shusuke Yagi, K Nitta, K Takata, Fumihiko Tada, Hiroyuki Kinoshita, Kazumi Takaishi, Hiroshi Kitahata","Tomohiro Soga, Shinji Kawahito, Naoji Mita, Shusuke Yagi, K Nitta, K Takata, Fumihiko Tada, Hiroyuki Kinoshita, Kazumi Takaishi, Hiroshi Kitahata","null","null","null","null","null","2021-10","Clinical Pediatric Anesthesia","Clinical Pediatric Anesthesia","Vol.27","No.1","3","8","eng","true","null","scientific_journal","null","null","null","1341-5603","null","null","null","null","null" "Clinically relevant concentration of propofol and benzodiazepines did not affect in vitro angiogenesis.","Clinically relevant concentration of propofol and benzodiazepines did not affect in vitro angiogenesis.","Kazumi Takaishi, Yasusei Kudo, Shinji Kawahito, Hiroshi Kitahata","Kazumi Takaishi, Yasusei Kudo, Shinji Kawahito, Hiroshi Kitahata","null","Angiogenesis, one of regenerative medicine, is essential in the process of wound healing. The detailed effects of intravenous anesthetics and sedatives used during perioperative period have not yet been clarified. We investigated the effects of benzodiazepines and propofol on in vitro capillary tube formation. The effects of midazolam, diazepam and propofol (1, 10, 50 M each) on proliferation of human umbilical vein endothelial cells (HUVEC) and normal human diploid fibroblasts (NHDF) were determined. Quantitation of migration was achieved by measuring the fluorescence of migrating HUVEC using angiogenesis system. The effects of midazolam, diazepam and propofol on in vitro angiogenesis were investigated in co-cultured HUVEC and NHDF incubated. The effects of midazolam on activation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinases were examined by Western blot analysis using phospho-specific antibodies. Parametric data were analyzed with one-way repeated measures analysis of variance followed by the Scheff test. A value of P < 0.05 was considered statistically significant. Fifty M of midazolam significantly impaired endothelial cell proliferation, migration, and in vitro capillary tube formation. Propofol, diazepam or lower dose midazolam did not show any enhancing or suppressive effects on in vitro angiogenesis. Fifty M of midazolam remarkably activated ERK, but not p38 MAPK in HUVEC. Propofol and benzodiazepines except high-dose midazolam did not affect in vitro angiogenesis. High-dose midazolam may impair in vitro capillary tube formation due to by suppressing proliferation and migration of endothelial cells via activation of ERK.","Angiogenesis, one of regenerative medicine, is essential in the process of wound healing. The detailed effects of intravenous anesthetics and sedatives used during perioperative period have not yet been clarified. We investigated the effects of benzodiazepines and propofol on in vitro capillary tube formation. The effects of midazolam, diazepam and propofol (1, 10, 50 M each) on proliferation of human umbilical vein endothelial cells (HUVEC) and normal human diploid fibroblasts (NHDF) were determined. Quantitation of migration was achieved by measuring the fluorescence of migrating HUVEC using angiogenesis system. The effects of midazolam, diazepam and propofol on in vitro angiogenesis were investigated in co-cultured HUVEC and NHDF incubated. The effects of midazolam on activation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinases were examined by Western blot analysis using phospho-specific antibodies. Parametric data were analyzed with one-way repeated measures analysis of variance followed by the Scheff test. A value of P < 0.05 was considered statistically significant. Fifty M of midazolam significantly impaired endothelial cell proliferation, migration, and in vitro capillary tube formation. Propofol, diazepam or lower dose midazolam did not show any enhancing or suppressive effects on in vitro angiogenesis. Fifty M of midazolam remarkably activated ERK, but not p38 MAPK in HUVEC. Propofol and benzodiazepines except high-dose midazolam did not affect in vitro angiogenesis. High-dose midazolam may impair in vitro capillary tube formation due to by suppressing proliferation and migration of endothelial cells via activation of ERK.","null","null","2021-08-28","Journal of Anesthesia","Journal of Anesthesia","Vol.35","No.6","870","878","eng","true","null","scientific_journal","null","null","10.1007/s00540-021-02993-x","1438-8359","null","null","null","null","null" "細胞骨格ターンオーバー調節物質による細胞内経路制御機構の解明と麻酔薬作用","細胞骨格ターンオーバー調節物質による細胞内経路制御機構の解明と麻酔薬作用","川人 伸次, 木下 浩之, 高石 和美, 曽我 朋宏, 八木 秀介, 北畑 洋","Shinji Kawahito, 木下 浩之, Kazumi Takaishi, Tomohiro Soga, Shusuke Yagi, Hiroshi Kitahata","null","null","null","null","null","2021-04","Precision Medicine","Precision Medicine","Vol.4","No.4","32","35","jpn","true","null","scientific_journal","null","null","null","2434-3625","null","null","null","null","null" "Pathophysiology and complications during extracorporeal circulation","Pathophysiology and complications during extracorporeal circulation","Shinji Kawahito, Tomohiro Soga, Shusuke Yagi, Naoji Mita, Kazumi Takaishi, Hiroyuki Kinoshita, Tetsuya Kitagawa, Hiroshi Kitahata","Shinji Kawahito, Tomohiro Soga, Shusuke Yagi, Naoji Mita, Kazumi Takaishi, Hiroyuki Kinoshita, Tetsuya Kitagawa, Hiroshi Kitahata","null","null","null","null","null","2020-08","The Journal of Medical Investigation : JMI","The Journal of Medical Investigation : JMI","Vol.67","No.3,4","229","235","eng","true","null","scientific_journal","null","null","10.2152/jmi.67.229","1349-6867","null","null","null","null","null" "Inferior alveolar nerve paresthesia caused by the extrusion of calcium hydroxide-based paste into themandibular canal: A case report.","Inferior alveolar nerve paresthesia caused by the extrusion of calcium hydroxide-based paste into themandibular canal: A case report.","Keiko Kudoh, Kazumi Takaishi, Takaharu Kudoh, Natsumi Takamaru, Kumiko Kamada, Youji Miyamoto","Keiko Kudoh, Kazumi Takaishi, Takaharu Kudoh, Natsumi Takamaru, Kumiko Kamada, Youji Miyamoto","null","null","null","null","null","2020-05","Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology","Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology","Vol.32","No.5","366","369","eng","true","null","scientific_journal","null","null","10.1016/j.ajoms.2020.05.005","2212-5558","null","null","null","null","null" "歯科麻酔に関連する薬剤の基礎的知識と安全な使用について","The Basic Knowledge and Safe Use of Drugs Related to Dental Anesthesia","高石 和美","Kazumi Takaishi","null","null","null","null","null","2020","日本歯科麻酔学会雑誌","Journal of Japanese Dental Society of Anesthesiology","Vol.48","No.2","93","99","jpn","true","true","scientific_journal","null","null","10.24569/jjdsa.48.2_93","2433-4480","null","https://ci.nii.ac.jp/naid/130007832237/","null","null","null" "Electrons released from both flavins of NADPH-P450 reductase contribute to the reductive mobilization of iron from ferritin.","Electrons released from both flavins of NADPH-P450 reductase contribute to the reductive mobilization of iron from ferritin.","Kazumi Takaishi, Hiroshi Kitahata","Kazumi Takaishi, Hiroshi Kitahata","null","Ferritin, an iron storage protein, plays an important role in iron homeostasis. The mechanism of reductive mobilization of iron from ferritin has not been clarified yet despite many studies. The aim of this study was to assess the mechanisms of the mobilization of iron from ferritin by NADPH P-450 reductase. Nucleotide-dependent flavoenzymes generated significant mobilization of iron from ferritin. The possibility of reductive mobilization of iron from ferritin by electrons released from flavin sites or heme site of two flavoenzymes was investigated to elucidate the mediator-independent mechanisms of such reductive mobilization. The mobilization by NADPH-P450 reductase in the presence of ferricyanide increased threefold, while in the presence of cytochrome C increased thirteen-fold. These results indicate that electrons released from both flavins of NADPH-P450 reductase contribute to the reductive mobilization of iron from ferritin. The mechanism of the mobilization of iron from ferritin is discussed. J. Med. Invest. 66 : 230-232, August, 2019.","Ferritin, an iron storage protein, plays an important role in iron homeostasis. The mechanism of reductive mobilization of iron from ferritin has not been clarified yet despite many studies. The aim of this study was to assess the mechanisms of the mobilization of iron from ferritin by NADPH P-450 reductase. Nucleotide-dependent flavoenzymes generated significant mobilization of iron from ferritin. The possibility of reductive mobilization of iron from ferritin by electrons released from flavin sites or heme site of two flavoenzymes was investigated to elucidate the mediator-independent mechanisms of such reductive mobilization. The mobilization by NADPH-P450 reductase in the presence of ferricyanide increased threefold, while in the presence of cytochrome C increased thirteen-fold. These results indicate that electrons released from both flavins of NADPH-P450 reductase contribute to the reductive mobilization of iron from ferritin. The mechanism of the mobilization of iron from ferritin is discussed. J. Med. Invest. 66 : 230-232, August, 2019.","null","null","2019-08","The Journal of Medical Investigation : JMI","The Journal of Medical Investigation : JMI","Vol.66","No.3.4","230","232","eng","true","null","scientific_journal","null","null","10.2152/jmi.66.230","1349-6867","null","null","null","null","null" "Continuous blood glucose monitoring during pediatric cardiopulmonary bypass.","Continuous blood glucose monitoring during pediatric cardiopulmonary bypass.","Nami Kakuta, Shinji Kawahito, Naoji Mita, Tomohiro Soga, Shusuke Yagi, Shiho Satomi, Fumihiko Tada, Kinoshita Hiroyuki, Kazumi Takaishi, Hiroshi Kitahata","Nami Kakuta, Shinji Kawahito, Naoji Mita, Tomohiro Soga, Shusuke Yagi, Shiho Satomi, Fumihiko Tada, Kinoshita Hiroyuki, Kazumi Takaishi, Hiroshi Kitahata","null","null","null","null","null","2019-08","Clinical Pediatric Anesthesia","Clinical Pediatric Anesthesia","Vol.25","No.1","3","7","eng","true","null","scientific_journal","null","null","null","1341-5603","null","null","null","null","null" "Accuracy and reliability of continuous blood glucose monitoring during pediatric cardiopulmonary bypass.","Accuracy and reliability of continuous blood glucose monitoring during pediatric cardiopulmonary bypass.","Shinji Kawahito, Naoji Mita, Tomohiro Soga, Shusuke Yagi, Nami Kakuta, Shiho Satomi, Hiroyuki Kinoshita, Kazumi Takaishi, Tetsuya Kitagawa, Hiroshi Kitahata","Shinji Kawahito, Naoji Mita, Tomohiro Soga, Shusuke Yagi, Nami Kakuta, Shiho Satomi, Hiroyuki Kinoshita, Kazumi Takaishi, Tetsuya Kitagawa, Hiroshi Kitahata","null","The purpose of this study was to assess the accuracy and reliability of a continuous blood glucose monitoring system (artificial endocrine pancreas; STG-55, Nikkiso, Tokyo, Japan) during pediatric cardiopulmonary bypass surgery. Twenty-five pediatric patients scheduled to undergo cardiovascular surgery with cardiopulmonary bypass (age 4 months to 11 years; body weight 5.6-59.7 kg) were enrolled. The glucose sensor line of the artificial endocrine pancreas was connected to the venous side of the cardiopulmonary bypass circuit and used for continuous blood glucose monitoring. We obtained 192 samples for blood gas assessment from the cardiopulmonary bypass circuit, and i-STAT (Abbott, East Windsor, NJ, USA) was used for conventional blood glucose assessment. The accuracies of continuous glucose measurements (STG-55) and conventional intermittent glucose measurements (i-STAT) during cardiopulmonary bypass were compared by means of Clarke error grid analysis. The results were divided into five zones, A, B, C, D, and E, and 78.6% of paired measurements were in zone A, while 21.4% were in zone B. We confirmed that the results of this continuous blood glucose monitoring system for cardiopulmonary bypass during pediatric cardiovascular surgery were highly reliable. An artificial endocrine pancreas may facilitate the safe use of intensive insulin therapy during pediatric cardiovascular surgery.","The purpose of this study was to assess the accuracy and reliability of a continuous blood glucose monitoring system (artificial endocrine pancreas; STG-55, Nikkiso, Tokyo, Japan) during pediatric cardiopulmonary bypass surgery. Twenty-five pediatric patients scheduled to undergo cardiovascular surgery with cardiopulmonary bypass (age 4 months to 11 years; body weight 5.6-59.7 kg) were enrolled. The glucose sensor line of the artificial endocrine pancreas was connected to the venous side of the cardiopulmonary bypass circuit and used for continuous blood glucose monitoring. We obtained 192 samples for blood gas assessment from the cardiopulmonary bypass circuit, and i-STAT (Abbott, East Windsor, NJ, USA) was used for conventional blood glucose assessment. The accuracies of continuous glucose measurements (STG-55) and conventional intermittent glucose measurements (i-STAT) during cardiopulmonary bypass were compared by means of Clarke error grid analysis. The results were divided into five zones, A, B, C, D, and E, and 78.6% of paired measurements were in zone A, while 21.4% were in zone B. We confirmed that the results of this continuous blood glucose monitoring system for cardiopulmonary bypass during pediatric cardiovascular surgery were highly reliable. An artificial endocrine pancreas may facilitate the safe use of intensive insulin therapy during pediatric cardiovascular surgery.","null","null","2019-06-24","Journal of Artificial Organs","Journal of Artificial Organs","Vol.22","No.4","353","356","eng","true","null","scientific_journal","null","null","10.1007/s10047-019-01111-9","1619-0904","null","null","null","null","null" "慢性炎症性脱髄性多発根ニューロパチー患者に対する肝切除術の麻酔経験","Ultrasound-guided Peripheral Nerve Block and General Anesthesia for Hepatectomy in a Patient with Chronic Inflammatory Demyelinating Polyneuropathy","箕田 直治, 川人 伸次, 里見 志帆, 笠井 飛鳥, 曽我 朋宏, 酒井 陽子, 高石 和美, 北畑 洋, 堤 保夫, 田中 克哉","Naoji Mita, Shinji Kawahito, Shiho Satomi, Asuka Kasai, Tomohiro Soga, Yoko Sakai, Kazumi Takaishi, Hiroshi Kitahata, Yasuo Tsutsumi, Katsuya Tanaka","null","null","null","null","null","2019-04","麻酔","Masui","Vol.68","No.4","409","412","jpn","true","null","scientific_journal","null","null","null","0021-4892","null","https://ci.nii.ac.jp/naid/40021860394/","null","null","null" "帝王切開後に産褥性心筋症を発症し心不全に陥った筋緊張性ジストロフィー妊婦の麻酔経験","Peripartum Cardiomyopathy after Cesarean Section in a Patient with Myotonic Dystrophy","箕田 直治, 川人 伸次, 張 雄紀, 里見 志帆, 植村 勇太, 酒井 陽子, 高石 和美, 北畑 洋, 堤 保夫, 田中 克哉","Naoji Mita, Shinji Kawahito, Yuki Hari, Shiho Satomi, Yuta Uemura, Yoko Sakai, Kazumi Takaishi, Hiroshi Kitahata, Yasuo Tsutsumi, Katsuya Tanaka","null","null","null","null","null","2019-02","麻酔","Masui","Vol.68","No.2","148","152","jpn","true","null","scientific_journal","null","null","null","0021-4892","null","https://ci.nii.ac.jp/naid/40021798033","null","null","null" "QTc延長患者における全身麻酔中のQTc変動","Intraoperative Change in QTc in a Patient with a Prolonged QTc Interval","山本 剛士, 高石 和美, 大塚 良, 藤原 茂樹, 江口 覚, 北畑 洋","山本 剛士, Kazumi Takaishi, 大塚 良, Shigeki Fujiwara Joseph Luke, Satoru Eguchi, Hiroshi Kitahata","null","
Long QT syndrome is characterized by a prolongation of the QT interval and a morphological change in the T wave on an electrocardiogram. Prolongation of the QT interval is associated with serious arrhythmia and may cause syncope and sudden death. A 13-year-old male with a prolonged corrected QT interval (QTc) on a preoperative electrocardiogram was scheduled to undergo the extractation of a supernumerary tooth under general anesthesia.
Although he had no remarkable past medical history, his QTc was prolonged to 514 ms on a 12-lead electrocardiogram. There was no history of syncope or sudden death in his family. The QTc at the time of his entrance into the operation room was 483 ms. During surgery, his QTc was continuously monitored in addition to the usual intraoperative monitoring. After the rapid introduction of anesthesia with remifentanil and propofol, the anesthesia was maintained with remifentanil and sevoflurane in oxygen and air. No significant change in the QTc was observed at the time of tracheal intubation accompanied by sympathetic stimulation. There was also no significant change in the QTc after the administration of atropine for bradycardia. However, when 2% lidocaine containing adrenaline was used for local anesthesia, the QTc gradually became prolonged reaching a maximum of 507 ms. In patients with a prolonged QT interval on a preoperative electrocardiogram, careful attention may be needed during the use of local anesthetics containing adrenaline. In addition, continuous monitoring of the QTc during surgery may be useful for the prevention of serious arrhythmias.
","Long QT syndrome is characterized by a prolongation of the QT interval and a morphological change in the T wave on an electrocardiogram. Prolongation of the QT interval is associated with serious arrhythmia and may cause syncope and sudden death. A 13-year-old male with a prolonged corrected QT interval (QTc) on a preoperative electrocardiogram was scheduled to undergo the extractation of a supernumerary tooth under general anesthesia.
Although he had no remarkable past medical history, his QTc was prolonged to 514 ms on a 12-lead electrocardiogram. There was no history of syncope or sudden death in his family. The QTc at the time of his entrance into the operation room was 483 ms. During surgery, his QTc was continuously monitored in addition to the usual intraoperative monitoring. After the rapid introduction of anesthesia with remifentanil and propofol, the anesthesia was maintained with remifentanil and sevoflurane in oxygen and air. No significant change in the QTc was observed at the time of tracheal intubation accompanied by sympathetic stimulation. There was also no significant change in the QTc after the administration of atropine for bradycardia. However, when 2% lidocaine containing adrenaline was used for local anesthesia, the QTc gradually became prolonged reaching a maximum of 507 ms. In patients with a prolonged QT interval on a preoperative electrocardiogram, careful attention may be needed during the use of local anesthetics containing adrenaline. In addition, continuous monitoring of the QTc during surgery may be useful for the prevention of serious arrhythmias.
","null","null","2019-02","日本歯科麻酔学会雑誌","Journal of Japanese Dental Society of Anesthesiology","Vol.47","No.2","53","55","jpn","true","null","scientific_journal","null","null","10.24569/jjdsa.47.2_53","0386-5835","null","https://ci.nii.ac.jp/naid/130007632933/","null","null","null" "The unique action of nicorandil on cerebral circulation.","The unique action of nicorandil on cerebral circulation.","Hiroyuki Kinoshita, Shinji Kawahito, Kazumi Takaishi","Hiroyuki Kinoshita, Shinji Kawahito, Kazumi Takaishi","null","null","null","null","null","2018-05-04","Journal of Anesthesia","Journal of Anesthesia","Vol.32","No.3","462","462","eng","true","null","scientific_journal","null","null","10.1007/s00540-018-2499-3","1438-8359","null","null","null","null","null" "Nasotracheal intubation through pharyngeal flap after pharyngeal flap construction.","Nasotracheal intubation through pharyngeal flap after pharyngeal flap construction.","Kazumi Takaishi, Shinji Kawahito, Shigeki Fujiwara Joseph Luke, Hiroshi Kitahata","Kazumi Takaishi, Shinji Kawahito, Shigeki Fujiwara Joseph Luke, Hiroshi Kitahata","null","null","null","null","null","2018-02-01","Journal of Clinical Anesthesia","Journal of Clinical Anesthesia","Vol.44","null","121","122","eng","true","null","scientific_journal","null","null","10.1016/j.jclinane.2017.11.026","1873-4529","null","null","null","null","null" "閉塞型睡眠時無呼吸症候群を伴った成人スティル病患者の嚢胞摘出術における静脈内鎮静法下患者管理の経験","閉塞型睡眠時無呼吸症候群を伴った成人スティル病患者の嚢胞摘出術における静脈内鎮静法下患者管理の経験","藤原 茂樹, 大塚 良, 尾上 真奈美, 江口 覚, 高石 和美, 北畑 洋","Shigeki Fujiwara Joseph Luke, 大塚 良, 尾上 真奈美, Satoru Eguchi, Kazumi Takaishi, Hiroshi Kitahata","null","null","null","null","null","2018-02","臨床麻酔","Journal of Clinical Anesthesia (Japan)","Vol.42","No.2","220","222","jpn","true","null","scientific_journal","null","null","null","0387-3668","null","null","null","null","null" "Stevens-Johnson症候群の既往がある難治性てんかん患者の全身麻酔経験","Stevens-Johnson症候群の既往がある難治性てんかん患者の全身麻酔経験","藤原 茂樹, 大塚 良, 尾上 真奈美, 江口 覚, 高石 和美, 北畑 洋","Shigeki Fujiwara Joseph Luke, 大塚 良, 尾上 真奈美, Satoru Eguchi, Kazumi Takaishi, Hiroshi Kitahata","null","null","null","null","null","2017-10","臨床麻酔","Journal of Clinical Anesthesia (Japan)","Vol.41","No.10","1424","1426","jpn","true","null","scientific_journal","null","null","null","0387-3668","null","null","null","null","null" "Successful treatment of mixed (mainly cancer) pain by tramadol preparations","Successful treatment of mixed (mainly cancer) pain by tramadol preparations","Shinji Kawahito, Tomohiro Soga, Naoji Mita, Shiho Satomi, Hiroyuk Kinoshita, Tomoko Arase, Akira Kondo, Hitoshi Miki, Kazumi Takaishi, Hiroshi Kitahata","Shinji Kawahito, Tomohiro Soga, Naoji Mita, Shiho Satomi, Hiroyuk Kinoshita, Tomoko Arase, Akira Kondo, Hitoshi Miki, Kazumi Takaishi, Hiroshi Kitahata","null","The patient, a 70-year-old Japanese woman diagnosed with parotid gland cancer, underwent wide excision and reconstruction (facial nerve ablation, nerve transposition). At 1 month after the surgery, she was brought to our hospital's pain medicine department because her postoperative pain and cancer-related pain were poorly controlled. She had already been prescribed a tramadol (37.5 mg)/acetaminophen (325 mg) combination tablet (5 tablets/day). However, in addition to the continuous pain in her face and lower limbs, she was troubled by a trigeminal neuralgia-like prominence ache. Because this pain could not be controlled by an increase to eight combination tablets per day, we switched her medication to a tramadol capsule. At 11 months post-surgery, we then switched her medication to an orally disintegrating tramadol tablet to improve medication adherence of the drug. From 14 months post-surgery, the patient also used a sustained-release tramadol preparation, and she was then able to sleep well. Her current regimen is an orally disintegrating sustained-release tablet combination (total 300 mg tramadol) per day, and she achieved sufficient pain relief. Because tramadol is not classified as a medical narcotic drug, it widely available and was shown here to be extremely useful for the treatment of our patient's mixed (mainly cancer) pain. J. Med. Invest. 64: 311-312, August, 2017.","The patient, a 70-year-old Japanese woman diagnosed with parotid gland cancer, underwent wide excision and reconstruction (facial nerve ablation, nerve transposition). At 1 month after the surgery, she was brought to our hospital's pain medicine department because her postoperative pain and cancer-related pain were poorly controlled. She had already been prescribed a tramadol (37.5 mg)/acetaminophen (325 mg) combination tablet (5 tablets/day). However, in addition to the continuous pain in her face and lower limbs, she was troubled by a trigeminal neuralgia-like prominence ache. Because this pain could not be controlled by an increase to eight combination tablets per day, we switched her medication to a tramadol capsule. At 11 months post-surgery, we then switched her medication to an orally disintegrating tramadol tablet to improve medication adherence of the drug. From 14 months post-surgery, the patient also used a sustained-release tramadol preparation, and she was then able to sleep well. Her current regimen is an orally disintegrating sustained-release tablet combination (total 300 mg tramadol) per day, and she achieved sufficient pain relief. Because tramadol is not classified as a medical narcotic drug, it widely available and was shown here to be extremely useful for the treatment of our patient's mixed (mainly cancer) pain. J. Med. Invest. 64: 311-312, August, 2017.","null","null","2017-08-01","The Journal of Medical Investigation : JMI","The Journal of Medical Investigation : JMI","Vol.64","No.3,4","311","312","eng","true","null","scientific_journal","null","null","10.2152/jmi.64.311","1349-6867","null","null","null","null","null" "Strict blood glucose control by an artificial endocrine pancreas during hepatectomy may prevent postoperative acute kidney injury","Strict blood glucose control by an artificial endocrine pancreas during hepatectomy may prevent postoperative acute kidney injury","Naoji Mita, Shinji Kawahito, Tomohiro Soga, Kazumi Takaishi, Hiroshi Kitahata, Munehide Matsuhisa, Mitsuo Shimada, Kinoshita Hiroyuki, Yasuo Tsutsumi, Katsuya Tanaka","Naoji Mita, Shinji Kawahito, Tomohiro Soga, Kazumi Takaishi, Hiroshi Kitahata, Munehide Matsuhisa, Mitsuo Shimada, Kinoshita Hiroyuki, Yasuo Tsutsumi, Katsuya Tanaka","null","The aim of the present study was to evaluate the usefulness of a closed-loop system (STG-55; Nikkiso, Tokyo, Japan), a type of artificial endocrine pancreas for the continuous monitoring and control of intraoperative blood glucose, for preventing postoperative acute kidney injury (AKI) in patients undergoing hepatectomy. Thirty-eight patients were enrolled in this study. Glucose concentrations were controlled with either a manual injection of insulin based on a commonly used sliding scale (manual insulin group, n = 19) or the programmed infusion of insulin determined by the control algorithm of the artificial endocrine pancreas (programmed insulin group, n = 19). After the induction of anesthesia, a 20-G intravenous catheter was inserted into the peripheral forearm vein of patients in the programmed insulin group and connected to an artificial endocrine pancreas (STG-55). The target range for glucose concentrations was set to 100-150 mg/dL. The mean serum creatinine concentrations of preoperative, postoperative 24 and 48 h were 0.72, 0.78, and 0.79 mg/dL in the programmed insulin group, and 0.81, 0.95, and 1.03 mg/dL in the manual insulin group, respectively. Elevations in serum creatinine concentrations postoperative 48 h were significantly suppressed in the programmed insulin group. The STG-55 closed-loop system was effective for maintaining strict blood glucose control during hepatectomy with minimal variability in blood glucose concentrations and for suppressing elevations in serum creatinine concentrations. Strict blood glucose control by an artificial endocrine pancreas during hepatectomy may prevent postoperative AKI.","The aim of the present study was to evaluate the usefulness of a closed-loop system (STG-55; Nikkiso, Tokyo, Japan), a type of artificial endocrine pancreas for the continuous monitoring and control of intraoperative blood glucose, for preventing postoperative acute kidney injury (AKI) in patients undergoing hepatectomy. Thirty-eight patients were enrolled in this study. Glucose concentrations were controlled with either a manual injection of insulin based on a commonly used sliding scale (manual insulin group, n = 19) or the programmed infusion of insulin determined by the control algorithm of the artificial endocrine pancreas (programmed insulin group, n = 19). After the induction of anesthesia, a 20-G intravenous catheter was inserted into the peripheral forearm vein of patients in the programmed insulin group and connected to an artificial endocrine pancreas (STG-55). The target range for glucose concentrations was set to 100-150 mg/dL. The mean serum creatinine concentrations of preoperative, postoperative 24 and 48 h were 0.72, 0.78, and 0.79 mg/dL in the programmed insulin group, and 0.81, 0.95, and 1.03 mg/dL in the manual insulin group, respectively. Elevations in serum creatinine concentrations postoperative 48 h were significantly suppressed in the programmed insulin group. The STG-55 closed-loop system was effective for maintaining strict blood glucose control during hepatectomy with minimal variability in blood glucose concentrations and for suppressing elevations in serum creatinine concentrations. Strict blood glucose control by an artificial endocrine pancreas during hepatectomy may prevent postoperative AKI.","null","null","2017-03","Journal of Artificial Organs","Journal of Artificial Organs","Vol.20","No.1","76","83","eng","true","null","scientific_journal","null","null","10.1007/s10047-016-0925-6","1619-0904","null","null","null","null","null" "Anesthetic management of a patient with unruptured sinus of valsalva aneurysm with right ventricular outflow tract obstruction.","Anesthetic management of a patient with unruptured sinus of valsalva aneurysm with right ventricular outflow tract obstruction.","Naoji Mita, Shinji Kawahito, Tomohiro Soga, Tosiko Katayama, Narutomo Wakamatsu, Tomiya Kawahara, Nami Kakuta, Eisuke Hamaguchi, Yasuo Tsutsumi, Katsuya Tanaka, Kazumi Takaishi, Hiroshi Kitahata","Naoji Mita, Shinji Kawahito, Tomohiro Soga, Tosiko Katayama, Narutomo Wakamatsu, Tomiya Kawahara, Nami Kakuta, Eisuke Hamaguchi, Yasuo Tsutsumi, Katsuya Tanaka, Kazumi Takaishi, Hiroshi Kitahata","null","null","null","null","null","2016-12","Circulation Control","Circulation Control","Vol.37","No.3","195","198","eng","true","null","scientific_journal","null","null","10.11312/ccm.37.195","0389-1844","null","null","null","null","null" "Role of transesophageal echocardiography during biventricular pacemaker implantation in children","Role of transesophageal echocardiography during biventricular pacemaker implantation in children","Nami Kakuta, Shinji Kawahito, Naoji Mita, Tomohiro Soga, Toshiko Katayama, Kohei Fukuta, Hiroaki Kawano, Fumihiko Tada, Yasuo M. Tsutsumi, Katsuya Tanaka, Kazumi Takaishi, Hiroshi Kitahata","Nami Kakuta, Shinji Kawahito, Naoji Mita, Tomohiro Soga, Toshiko Katayama, Kohei Fukuta, Hiroaki Kawano, Fumihiko Tada, Yasuo M. Tsutsumi, Katsuya Tanaka, Kazumi Takaishi, Hiroshi Kitahata","null","null","null","null","null","2015-08","Clinical Pediatric Anesthesia","Clinical Pediatric Anesthesia","Vol.21","null","182","185","eng","true","null","scientific_journal","null","null","null","1341-5603","null","null","null","null","null" "特発性間質性肺炎を合併した患者に対する口腔外科長時間手術の全身麻酔経験","特発性間質性肺炎を合併した患者に対する口腔外科長時間手術の全身麻酔経験","青山 智祐, 高石 和美, 大塚 良, 江口 覚, 富岡 重正, 北畑 洋","Tomohiro Aoyama, Kazumi Takaishi, Ohtuka Ryo, Satoru Eguchi, Shigemasa Tomioka, Hiroshi Kitahata","null","null","null","null","null","2015-04-15","日本歯科麻酔学会雑誌","Journal of Japanese Dental Society of Anesthesiology","Vol.43","No.2","265","267","jpn","true","null","scientific_journal","null","null","null","0386-5835","null","null","null","null","null" "静脈穿刺により発症した血管迷走神経性失神時に心拍変動解析を行った1例","静脈穿刺により発症した血管迷走神経性失神時に心拍変動解析を行った1例","大塚 良, 青山 智祐, 江口 覚, 高石 和美, 富岡 重正, 北畑 洋","Ohtuka Ryo, Tomohiro Aoyama, Satoru Eguchi, Kazumi Takaishi, Shigemasa Tomioka, Hiroshi Kitahata","null","null","null","null","null","2015-04-15","日本歯科麻酔学会雑誌","Journal of Japanese Dental Society of Anesthesiology","Vol.43","No.2","268","270","jpn","true","null","scientific_journal","null","null","null","0386-5835","null","null","null","null","null" "Impact of newly developed, next-generation artificial endocrine pancreas","Impact of newly developed, next-generation artificial endocrine pancreas","Noriko Kambe, Shinji Kawahito, Naoji Mita, Kazumi Takaishi, Tosiko Katayama, Yoko Sakai, Tomohiro Soga, Hiroaki Kawano, Munehide Matsuhisa, Mitsuo Shimada, Tetsuya Kitagawa, Hiroshi Kitahata","Noriko Kambe, Shinji Kawahito, Naoji Mita, Kazumi Takaishi, Tosiko Katayama, Yoko Sakai, Tomohiro Soga, Hiroaki Kawano, Munehide Matsuhisa, Mitsuo Shimada, Tetsuya Kitagawa, Hiroshi Kitahata","null","Recent studies have shown that strict perioperative blood glucose management may reduce mortality and morbidity in critically ill adult patients. The purpose of this study was to assess the accuracy and efficacy of the intraoperative application of a newly developed, next-generation artificial endocrine pancreas (STG-55, Nikkiso Co., Ltd., Tokyo, Japan). Twenty patients scheduled to undergo surgery were enrolled in this study. The STG-55 is designed to be more user-friendly than its conventional counterpart (STG-22) while maintaining the latter's fundamental functions, such as a closed-loop system using algorithms for insulin and glucose infusion. After anesthetic induction, a 20G intravenous catheter was inserted into a peripheral forearm vein and connected to a continuous blood glucose monitor. The resultant 105 scores for paired blood glucose values were compared by Bland-Altman analysis. Stable blood glucose values were maintained automatically, and there were no complications related to use of the STG-55. A close correlation (r=0.96) was observed between continuous glucose measurements using the STG-55 and conventional intermittent glucose measurements. The difficulty of manipulation using this system was decreased by improved preparation procedures. The glycemic control system using the STG-55 could provide an alternative way to achieve effective and safe perioperative glycemic control.","Recent studies have shown that strict perioperative blood glucose management may reduce mortality and morbidity in critically ill adult patients. The purpose of this study was to assess the accuracy and efficacy of the intraoperative application of a newly developed, next-generation artificial endocrine pancreas (STG-55, Nikkiso Co., Ltd., Tokyo, Japan). Twenty patients scheduled to undergo surgery were enrolled in this study. The STG-55 is designed to be more user-friendly than its conventional counterpart (STG-22) while maintaining the latter's fundamental functions, such as a closed-loop system using algorithms for insulin and glucose infusion. After anesthetic induction, a 20G intravenous catheter was inserted into a peripheral forearm vein and connected to a continuous blood glucose monitor. The resultant 105 scores for paired blood glucose values were compared by Bland-Altman analysis. Stable blood glucose values were maintained automatically, and there were no complications related to use of the STG-55. A close correlation (r=0.96) was observed between continuous glucose measurements using the STG-55 and conventional intermittent glucose measurements. The difficulty of manipulation using this system was decreased by improved preparation procedures. The glycemic control system using the STG-55 could provide an alternative way to achieve effective and safe perioperative glycemic control.","null","null","2015-02","The Journal of Medical Investigation : JMI","The Journal of Medical Investigation : JMI","Vol.62","No.1-2","41","44","eng","true","null","scientific_journal","null","null","10.2152/jmi.62.41","1349-6867","null","null","null","null","null" "Cuffed oropharyngeal airway for difficult airway management.","Cuffed oropharyngeal airway for difficult airway management.","Kazumi Takaishi, Shinji Kawahito, Shigemasa Tomioka, Satoru Eguchi, Hiroshi Kitahata","Kazumi Takaishi, Shinji Kawahito, Shigemasa Tomioka, Satoru Eguchi, Hiroshi Kitahata","null","Abstract Difficulties with airway management are often caused by anatomic abnormalities due to previous oral surgery. We performed general anesthesia for a patient who had undergone several operations such as hemisection of the mandible and reconstructive surgery with a deltopectoralis flap, resulting in severe maxillofacial deformation. This made it impossible to ventilate with a face mask and to intubate in the normal way. An attempt at oral awake intubation using fiberoptic bronchoscopy was unsuccessful because of severe anatomical abnormality of the neck. We therefore decided to perform retrograde intubation and selected the cuffed oropharyngeal airway (COPA) for airway management. We inserted the COPA, not through the patient's mouth but through the abnormal oropharyngeal space. Retrograde nasal intubation was accomplished with controlled ventilation through the COPA, which proved to be very useful for this difficult airway management during tracheal intubation even though the method was unusual.","Abstract Difficulties with airway management are often caused by anatomic abnormalities due to previous oral surgery. We performed general anesthesia for a patient who had undergone several operations such as hemisection of the mandible and reconstructive surgery with a deltopectoralis flap, resulting in severe maxillofacial deformation. This made it impossible to ventilate with a face mask and to intubate in the normal way. An attempt at oral awake intubation using fiberoptic bronchoscopy was unsuccessful because of severe anatomical abnormality of the neck. We therefore decided to perform retrograde intubation and selected the cuffed oropharyngeal airway (COPA) for airway management. We inserted the COPA, not through the patient's mouth but through the abnormal oropharyngeal space. Retrograde nasal intubation was accomplished with controlled ventilation through the COPA, which proved to be very useful for this difficult airway management during tracheal intubation even though the method was unusual.","null","null","2014-09","Anesthesia Progress","Anesthesia Progress","Vol.61","No.3","107","110","eng","true","null","scientific_journal","null","null","10.2344/0003-3006-61.3.107","0003-3006","null","null","null","null","null" "Propofol-induced relaxation of rat aorta is altered by aging.","Propofol-induced relaxation of rat aorta is altered by aging.","Yoko Sakai, Shinji Kawahito, Kazumi Takaishi, Naoji Mita, Hiroyuki Kinoshita, Noboru Hatakeyama, Toshiharu Azma, Yutaka Nakaya, Hiroshi Kitahata","Yoko Sakai, Shinji Kawahito, Kazumi Takaishi, Naoji Mita, Hiroyuki Kinoshita, Noboru Hatakeyama, Toshiharu Azma, Yutaka Nakaya, Hiroshi Kitahata","null","Propofol causes vasodilation via endothelium-dependent and -independent mechanisms. Because endothelial function is impaired with aging, the effects of propofol on endothelium-dependent vasodilation might be altered by aging. The aim of this study was thus to determine the effects of aging on vascular responses to propofol. Young (4-6 weeks old) or adult (16-25 weeks old) rats were anesthetized with sevoflurane. The thoracic aorta was dissected and cut into pieces 3-4 mm in length. In some rings, the endothelium was deliberately removed. The ring segment of the aorta was mounted for isometric force recording at a resting tension of 0.5-1.0 g in a 2 ml organ bath, containing Krebs-Ringer bicarbonate buffer. Arteries were precontracted with phenylephrine, and the function of endothelium was confirmed with acetylcholine. Then, we studied the concentration-dependent effects of propofol in endothelium-intact (control group) and -denuded aortic rings (denuded group), as well as those treated with N()-nitro-L-arginine methylester (L-NAME group). Relaxation due to propofol was observed in the control groups of both young and adult rats in a concentration-dependent manner, but the magnitude of relaxation was significantly greater in young rats. In addition, in young rats, relaxation due to propofol was significantly and equally reduced in both L-NAME and denuded groups at all propofol concentrations that we studied (10(-6)-10(-3) M). In adult rats, relaxation due to propofol was quite similar between control and L-NAME groups at all propofol concentrations, whereas it was significantly reduced in the denuded group. These results suggest that endothelium-derived nitric oxide plays an important role in propofol-induced vasodilation in young rats, but not in adult rats. J. Med. Invest. 61: 278-284, August, 2014.","Propofol causes vasodilation via endothelium-dependent and -independent mechanisms. Because endothelial function is impaired with aging, the effects of propofol on endothelium-dependent vasodilation might be altered by aging. The aim of this study was thus to determine the effects of aging on vascular responses to propofol. Young (4-6 weeks old) or adult (16-25 weeks old) rats were anesthetized with sevoflurane. The thoracic aorta was dissected and cut into pieces 3-4 mm in length. In some rings, the endothelium was deliberately removed. The ring segment of the aorta was mounted for isometric force recording at a resting tension of 0.5-1.0 g in a 2 ml organ bath, containing Krebs-Ringer bicarbonate buffer. Arteries were precontracted with phenylephrine, and the function of endothelium was confirmed with acetylcholine. Then, we studied the concentration-dependent effects of propofol in endothelium-intact (control group) and -denuded aortic rings (denuded group), as well as those treated with N()-nitro-L-arginine methylester (L-NAME group). Relaxation due to propofol was observed in the control groups of both young and adult rats in a concentration-dependent manner, but the magnitude of relaxation was significantly greater in young rats. In addition, in young rats, relaxation due to propofol was significantly and equally reduced in both L-NAME and denuded groups at all propofol concentrations that we studied (10(-6)-10(-3) M). In adult rats, relaxation due to propofol was quite similar between control and L-NAME groups at all propofol concentrations, whereas it was significantly reduced in the denuded group. These results suggest that endothelium-derived nitric oxide plays an important role in propofol-induced vasodilation in young rats, but not in adult rats. J. Med. Invest. 61: 278-284, August, 2014.","null","null","2014-08","The Journal of Medical Investigation : JMI","The Journal of Medical Investigation : JMI","Vol.61","No.3-4","278","284","eng","true","null","scientific_journal","null","null","10.2152/jmi.61.278","1349-6867","null","null","null","null","null" "Usefulness of artificial endocrine pancreas during resection of insulinoma.","Usefulness of artificial endocrine pancreas during resection of insulinoma.","Kayo Hirose, Shinji Kawahito, Naoji Mita, Kazumi Takaishi, Tomiya Kawahara, Tomohiro Soga, Toshiko Katayama, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Mitsuo Shimada, Munehide Matsuhisa, Hiroshi Kitahata","Kayo Hirose, Shinji Kawahito, Naoji Mita, Kazumi Takaishi, Tomiya Kawahara, Tomohiro Soga, Toshiko Katayama, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Mitsuo Shimada, Munehide Matsuhisa, Hiroshi Kitahata","null","A 71-year-old woman had an episode of syncope due to hypoglycemia of 27 mg/dl. She was diagnosed with insulinoma and scheduled for laparoscopic enucleation along with the use of an artificial endocrine pancreas (STG-22, Nikkiso Co., Ltd., Tokyo, Japan). Anesthesia was maintained with sevoflurane and remifentanil. Her blood glucose level was controlled using the artificial endocrine pancreas, which enabled continuous blood glucose monitoring and computer-operated glucose and insulin infusion to maintain the blood glucose level at a steady state. The target concentration of blood glucose was set at 80-120 mg/dl during surgery. Until removal of the tumor, the blood glucose level was kept at around 80-100 mg/dl. After removal of the tumor, the blood glucose level gradually increased, but it was kept in the normal range by the artificial endocrine pancreas. The artificial endocrine pancreas was useful to monitor and maintain blood glucose levels during and after the removal of insulinoma, without any hyper- or hypoglycemia. J. Med. Invest. 61: 421-425, August, 2014.","A 71-year-old woman had an episode of syncope due to hypoglycemia of 27 mg/dl. She was diagnosed with insulinoma and scheduled for laparoscopic enucleation along with the use of an artificial endocrine pancreas (STG-22, Nikkiso Co., Ltd., Tokyo, Japan). Anesthesia was maintained with sevoflurane and remifentanil. Her blood glucose level was controlled using the artificial endocrine pancreas, which enabled continuous blood glucose monitoring and computer-operated glucose and insulin infusion to maintain the blood glucose level at a steady state. The target concentration of blood glucose was set at 80-120 mg/dl during surgery. Until removal of the tumor, the blood glucose level was kept at around 80-100 mg/dl. After removal of the tumor, the blood glucose level gradually increased, but it was kept in the normal range by the artificial endocrine pancreas. The artificial endocrine pancreas was useful to monitor and maintain blood glucose levels during and after the removal of insulinoma, without any hyper- or hypoglycemia. J. Med. Invest. 61: 421-425, August, 2014.","null","null","2014-08","The Journal of Medical Investigation : JMI","The Journal of Medical Investigation : JMI","Vol.61","No.3-4","421","425","eng","true","null","scientific_journal","null","null","10.2152/jmi.61.421","1349-6867","null","null","null","null","null" "Role of an intraoperative single-plane transesophageal echocardiography probe for infants with congenital heart disease","Role of an intraoperative single-plane transesophageal echocardiography probe for infants with congenital heart disease","Nami Kakuta, Shinji Kawahito, Tomohiro Soga, Naoji Mita, Kouhei Fukuta, Narutomo Wakamatsu, Yoko Sakai, Tosiko Katayama, Fumihiko Tada, Kazumi Takaishi, Hiroshi Kitahata","Nami Kakuta, Shinji Kawahito, Tomohiro Soga, Naoji Mita, Kouhei Fukuta, Narutomo Wakamatsu, Yoko Sakai, Tosiko Katayama, Fumihiko Tada, Kazumi Takaishi, Hiroshi Kitahata","null","null","null","null","null","2014-07","Clinical Pediatric Anesthesia","Clinical Pediatric Anesthesia","Vol.20","No.1","231","235","eng","true","null","scientific_journal","null","null","null","null","null","null","null","null","null" "いわゆる病病連携による障害者歯科医療連携が奏功した集学的歯科治療について","いわゆる病病連携による障害者歯科医療連携が奏功した集学的歯科治療について","桃田 幸弘, 高野 栄之, 可児 耕一, 高石 和美, 中川 弘, 富岡 重正, 郡 由紀子, 橋本 俊顕, 北畑 洋, 東 雅之","Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Kazumi Takaishi, Hiroshi Nakagawa, Shigemasa Tomioka, Yukiko Kori, 橋本 俊顕, Hiroshi Kitahata, Masayuki Azuma","null","null","null","null","null","2014-02","四国歯学会雑誌","Shikoku Dental Research","Vol.26","No.2","35","40","jpn","true","null","scientific_journal","null","null","null","0914-6091","null","null","null","null","null" "Increase in prominence of electrocardiographic J waves after a single dose of propofol in a patient with early ventricular repolarisation.","Increase in prominence of electrocardiographic J waves after a single dose of propofol in a patient with early ventricular repolarisation.","Kazumi Takaishi, Shinji Kawahito, Hirotsugu Yamada, Takeshi Soeki, Masataka Sata, Hiroshi Kitahata","Kazumi Takaishi, Shinji Kawahito, Hirotsugu Yamada, Takeshi Soeki, Masataka Sata, Hiroshi Kitahata","null","J waves appear on an electrocardiogram as an elevation of the J point in the terminal portion of the QRS complex. J waves are often benign, but may be associated with malignant ventricular arrhythmias. In some cases, such problems appear to have been precipitated by propofol infusions. We observed a sudden increase in J waves and profound hypotension following a single intravenous dose of propofol in an 84-year-old woman with early repolarisation in the inferior ventricular wall. When early repolarisation (as shown by electrocardiographic J waves) is observed in the inferior ventricular wall pre-operatively, patients should be carefully monitored. Myocardial ischaemia and the use of drugs that might worsen J waves should be avoided.","J waves appear on an electrocardiogram as an elevation of the J point in the terminal portion of the QRS complex. J waves are often benign, but may be associated with malignant ventricular arrhythmias. In some cases, such problems appear to have been precipitated by propofol infusions. We observed a sudden increase in J waves and profound hypotension following a single intravenous dose of propofol in an 84-year-old woman with early repolarisation in the inferior ventricular wall. When early repolarisation (as shown by electrocardiographic J waves) is observed in the inferior ventricular wall pre-operatively, patients should be carefully monitored. Myocardial ischaemia and the use of drugs that might worsen J waves should be avoided.","null","null","2014-02","Anaesthesia","Anaesthesia","Vol.69","No.2","170","175","eng","true","null","scientific_journal","null","null","10.1111/anae.12448","1365-2044","null","null","null","null","null" "Local anesthetics inhibit nitric oxide production and l-arginine uptake in cultured bovine aortic endothelial cells.","Local anesthetics inhibit nitric oxide production and l-arginine uptake in cultured bovine aortic endothelial cells.","Kazumi Takaishi, Hiroshi Kitahata, Shinji Kawahito","Kazumi Takaishi, Hiroshi Kitahata, Shinji Kawahito","null","Previous studies have shown that local anesthetics have various effects on nitric oxide (NO) production, but the mechanisms remain unclear. The purpose of this study was to evaluate the effects of local anesthetics on NO production and 2-amino-5-guanidinopentanoic acid (l-arginine) uptake in one cell line. Cultured bovine aortic endothelial cells (BAEC) were stimulated with bradykinin and/or acetylcholine to activate endothelial NO synthase (NOS). BAEC were also incubated with interleukin-1β and lipopolysaccharide to stimulate inducible NOS. NO production was measured with the rapid spectrophotometric method, and l-arginine uptake was measured with high performance liquid chromatography. To assess the effects of local anesthetics, NO production and l-arginine uptake were measured in the presence or absence of procaine or lidocaine. NO was produced in BAEC stimulated with bradykinin and acetylcholine or interleukin-1β and lipopolysaccharide, but NO production was not affected by the addition of superoxide dismutase. In the cells stimulated with bradykinin and acetylcholine, 10 μM each of procaine and lidocaine significantly inhibited NO production by 35% and 20%, respectively. In the cells incubated with interleukin-1ß and lipopolysaccharide, the same quantities of procaine and lidocaine significantly inhibited NO production by 15% and 10%, respectively. Both procaine and lidocaine significantly suppressed l-arginine uptake in BAEC stimulated with either bradykinin/acetylcholine or interleukin-1β/lipopolysaccharide. It is suggested that inhibitory effects of procaine and lidocaine on NO production are partially due to suppression of l-arginine uptake.","Previous studies have shown that local anesthetics have various effects on nitric oxide (NO) production, but the mechanisms remain unclear. The purpose of this study was to evaluate the effects of local anesthetics on NO production and 2-amino-5-guanidinopentanoic acid (l-arginine) uptake in one cell line. Cultured bovine aortic endothelial cells (BAEC) were stimulated with bradykinin and/or acetylcholine to activate endothelial NO synthase (NOS). BAEC were also incubated with interleukin-1β and lipopolysaccharide to stimulate inducible NOS. NO production was measured with the rapid spectrophotometric method, and l-arginine uptake was measured with high performance liquid chromatography. To assess the effects of local anesthetics, NO production and l-arginine uptake were measured in the presence or absence of procaine or lidocaine. NO was produced in BAEC stimulated with bradykinin and acetylcholine or interleukin-1β and lipopolysaccharide, but NO production was not affected by the addition of superoxide dismutase. In the cells stimulated with bradykinin and acetylcholine, 10 μM each of procaine and lidocaine significantly inhibited NO production by 35% and 20%, respectively. In the cells incubated with interleukin-1ß and lipopolysaccharide, the same quantities of procaine and lidocaine significantly inhibited NO production by 15% and 10%, respectively. Both procaine and lidocaine significantly suppressed l-arginine uptake in BAEC stimulated with either bradykinin/acetylcholine or interleukin-1β/lipopolysaccharide. It is suggested that inhibitory effects of procaine and lidocaine on NO production are partially due to suppression of l-arginine uptake.","null","null","2013-02-24","European Journal of Pharmacology","European Journal of Pharmacology","Vol.704","No.1-3","58","63","eng","true","null","scientific_journal","null","null","10.1016/j.ejphar.2013.02.014","1879-0712","null","null","null","null","null" "Recent less-invasive circulatory monitoring during renal transplantation.","Recent less-invasive circulatory monitoring during renal transplantation.","Tomohiro Soga, Shinji Kawahito, Nami Kakuta, Tosiko Katayama, Narutomo Wakamatsu, Kazumi Takaishi, Kunihisa Yamaguchi, Hirofumi Izaki, Hiro-omi Kanayama, Hiroshi Kitahata, Shuzo Oshita","Tomohiro Soga, Shinji Kawahito, Nami Kakuta, Tosiko Katayama, Narutomo Wakamatsu, Kazumi Takaishi, Kunihisa Yamaguchi, Hirofumi Izaki, Hiro-omi Kanayama, Hiroshi Kitahata, Shuzo Oshita","null","For anesthetic management during renal transplantation, it is necessary to maintain the blood flow and function of the transplanted kidney by performing massive fluid management and stabilizing blood pressure. We report anesthetic management for renal transplantation with a less-invasive circulatory monitoring system (Edwards Life Sciences Co., Ltd., Irvine, California, U.S.A.). In November 2010, renal transplantation was started in our hospital, and performed in 6 patients. In the first patient, fluid/circulatory management was conducted by connecting a standard arterial line and a standard central venous (CV) line. In the second patient, a FloTrac(TM) system and a standard CV line were used. In the third patient, a standard arterial line and a PreSep(TM) CV Oximetry Catheter were used. In the fourth and fifth patients, a FloTrac(TM) and a PreSep(TM) were used. In the latest patient, FloTrac(TM) and PreSep(TM) were connected to an EV1000(TM) Clinical Platform for fluid/circulatory management. The establishment of high-visibility monitors was useful for evaluating the condition and confirming the effects. As there are marked changes in hemodynamics, the CV pressure, which has been used as a parameter of fluid management, is not reliable in renal failure patients with a high incidence of cardiovascular complications. Advances in noninvasive circulatory monitoring with dynamic indices may improve the safety of anesthetic management during renal transplantation.","For anesthetic management during renal transplantation, it is necessary to maintain the blood flow and function of the transplanted kidney by performing massive fluid management and stabilizing blood pressure. We report anesthetic management for renal transplantation with a less-invasive circulatory monitoring system (Edwards Life Sciences Co., Ltd., Irvine, California, U.S.A.). In November 2010, renal transplantation was started in our hospital, and performed in 6 patients. In the first patient, fluid/circulatory management was conducted by connecting a standard arterial line and a standard central venous (CV) line. In the second patient, a FloTrac(TM) system and a standard CV line were used. In the third patient, a standard arterial line and a PreSep(TM) CV Oximetry Catheter were used. In the fourth and fifth patients, a FloTrac(TM) and a PreSep(TM) were used. In the latest patient, FloTrac(TM) and PreSep(TM) were connected to an EV1000(TM) Clinical Platform for fluid/circulatory management. The establishment of high-visibility monitors was useful for evaluating the condition and confirming the effects. As there are marked changes in hemodynamics, the CV pressure, which has been used as a parameter of fluid management, is not reliable in renal failure patients with a high incidence of cardiovascular complications. Advances in noninvasive circulatory monitoring with dynamic indices may improve the safety of anesthetic management during renal transplantation.","null","null","2013-02","The Journal of Medical Investigation : JMI","The Journal of Medical Investigation : JMI","Vol.60","No.1, 2","159","163","eng","true","null","scientific_journal","null","null","10.2152/jmi.60.159","1349-6867","null","null","null","null","null" "尋常性天疱瘡患者における頬粘膜腫瘍切除術の全身麻酔経験","Anesthetic Management for Buccal Mucosa Tumor Resection in a Patient with Pemphigus Vulgaris","立石 智子, 富岡 重正, 古北 まゆ子, 高瀬 奈緒, 大西 杏奈, 高石 和美, 江口 覚, 北畑 洋","Tomoko Tatsuishi, Shigemasa Tomioka, Furukita Mayuko, Takase Nao, Anna Ohnishi, Kazumi Takaishi, Satoru Eguchi, Hiroshi Kitahata","null","null","null","null","null","2012-10-15","日本歯科麻酔学会雑誌","Journal of Japanese Dental Society of Anesthesiology","Vol.40","No.5","610","611","jpn","true","null","scientific_journal","null","null","null","0386-5835","null","http://ci.nii.ac.jp/naid/10031121824/","null","null","null" "Molecular mechanisms of the inhibitory effects of clonidine on vascular adenosine triphosphate-sensitive potassium channels.","Molecular mechanisms of the inhibitory effects of clonidine on vascular adenosine triphosphate-sensitive potassium channels.","Shinji Kawahito, Takashi Kawano, Hiroshi Kitahata, Jun Oto, Akira Takahashi, Kazumi Takaishi, Nagakatsu Harada, Tadahiko Nakagawa, Hiroyuki Kinoshita, Toshiharu Azma, Yutaka Nakaya, Shuzo Oshita","Shinji Kawahito, Takashi Kawano, Hiroshi Kitahata, Jun Oto, Akira Takahashi, Kazumi Takaishi, Nagakatsu Harada, Tadahiko Nakagawa, Hiroyuki Kinoshita, Toshiharu Azma, Yutaka Nakaya, Shuzo Oshita","null","We investigated the effects of the imidazoline-derived α2-adrenoceptor agonist clonidine on vascular adenosine triphosphate-sensitive potassium (K(ATP)) channel activity in rat vascular smooth muscle cells and recombinant vascular K(ATP) channels transiently expressed in COS-7 cells. Using the patch-clamp method, we investigated the effects of clonidine on the following: (1) native vascular K(ATP) channels; (2) recombinant K(ATP) channels with different combinations of various types of inwardly rectifying potassium channel (Kir6.0 family: Kir6.1, 6.2) and sulfonylurea receptor (SUR1, 2A, 2B) subunits; (3) SUR-deficient channels derived from a truncated isoform of the Kir6.2 subunit (Kir6.2ΔC36 channels); and (4) mutant Kir6.2ΔC36 channels with diminished sensitivity to ATP (Kir6.2ΔC36-K185Q channels). Clonidine (≥3 × 10(-8) M) inhibited native K(ATP) channel activity in cell-attached configurations with a half-maximal inhibitory concentration value of 1.21 × 10(-6) M and in inside-out configurations with a half-maximal inhibitory concentration value of 0.89 × 10(-6) M. With similar potency, clonidine (10(-6) or 10(-3) M) also inhibited the activities of various recombinant SUR/Kir6.0 K(ATP) channels, the Kir6.2ΔC36 channel, and the Kir6.2ΔC36-K185Q channel. Clinically relevant concentrations of clonidine inhibit K(ATP) channel activity in vascular smooth muscle cells. This inhibition seems to be the result of its effect on the Kir6.0 subunit and not on the SUR subunit.","We investigated the effects of the imidazoline-derived α2-adrenoceptor agonist clonidine on vascular adenosine triphosphate-sensitive potassium (K(ATP)) channel activity in rat vascular smooth muscle cells and recombinant vascular K(ATP) channels transiently expressed in COS-7 cells. Using the patch-clamp method, we investigated the effects of clonidine on the following: (1) native vascular K(ATP) channels; (2) recombinant K(ATP) channels with different combinations of various types of inwardly rectifying potassium channel (Kir6.0 family: Kir6.1, 6.2) and sulfonylurea receptor (SUR1, 2A, 2B) subunits; (3) SUR-deficient channels derived from a truncated isoform of the Kir6.2 subunit (Kir6.2ΔC36 channels); and (4) mutant Kir6.2ΔC36 channels with diminished sensitivity to ATP (Kir6.2ΔC36-K185Q channels). Clonidine (≥3 × 10(-8) M) inhibited native K(ATP) channel activity in cell-attached configurations with a half-maximal inhibitory concentration value of 1.21 × 10(-6) M and in inside-out configurations with a half-maximal inhibitory concentration value of 0.89 × 10(-6) M. With similar potency, clonidine (10(-6) or 10(-3) M) also inhibited the activities of various recombinant SUR/Kir6.0 K(ATP) channels, the Kir6.2ΔC36 channel, and the Kir6.2ΔC36-K185Q channel. Clinically relevant concentrations of clonidine inhibit K(ATP) channel activity in vascular smooth muscle cells. This inhibition seems to be the result of its effect on the Kir6.0 subunit and not on the SUR subunit.","null","null","2011-10-14","Anesthesia & Analgesia","Anesthesia & Analgesia","Vol.113","No.6","1374","1380","eng","true","null","scientific_journal","null","null","10.1213/ANE.0b013e3182321142","1526-7598","null","null","null","null","null" "小児患者の精神鎮静法に関する過去10年間の検討","A retrospective survey of conscious sedation used in children undergoing oral surgery or dental treatment during e ten-year period at the Tokushima University Hospital","高石 和美, 富岡 重正, 江口 覚, 中井 恵, 岩田 英道, 榎本 奈実, 髙丸 菜都美, 北畑 洋","Kazumi Takaishi, Shigemasa Tomioka, Satoru Eguchi, Megumi NAKAI, Hidemichi IWATA, Nami ENOMOTO, Natsumi Takamaru, Hiroshi Kitahata","null","null","null","null","null","2010-04-15","日本歯科麻酔学会雑誌","Journal of Japanese Dental Society of Anesthesiology","Vol.38","No.2","176","179","jpn","true","null","scientific_journal","null","null","null","0386-5835","null","http://ci.nii.ac.jp/naid/10026405028/","null","null","null" "当歯科診療所における障害者歯科治療時の鎮静法の実態と有用性","Intravenous Sedation of Persons with Disabilities during Dental Treatment in Dental Clinics","百田 義弘, 小谷 順一郎, 高石 和美, 重松 雅人, 鈴木 美穂","百田 義弘, 小谷 順一郎, Kazumi Takaishi, 重松 雅人, 鈴木 美穂","null","null","null","null","null","2009-06-30","障害者歯科","Journal of the Japanese Society for Disability and Oral Health","Vol.30","No.2","125","129","jpn","true","null","scientific_journal","null","null","null","0913-1663","null","https://search.jamas.or.jp/link/ui/2009283917","null","null","null" "アフリカツメガエル卵母細胞に発現したアクアポリン5に対する全身麻酔薬の作用","The Effects of General Anesthetics on Aquaporin 5 Expressed in Xenopus Oocytes","富岡 重正, 高石 和美, 中條 信義","Shigemasa Tomioka, Kazumi Takaishi, Nobuyoshi Nakajo","null","null","null","null","null","2007-10-15","日本歯科麻酔学会雑誌","Journal of Japanese Dental Society of Anesthesiology","Vol.35","No.5","662-668","662-668","jpn","true","null","scientific_journal","null","null","null","0386-5835","null","http://ci.nii.ac.jp/naid/10019775322/","null","null","null" "ガム噛みがストレス反応に与える影響","ガム噛みがストレス反応に与える影響","中條 信義, 富岡 重正, 高石 和美, 佐藤 健二","Nobuyoshi Nakajo, Shigemasa Tomioka, Kazumi Takaishi, Kenji Sato","null","null","null","null","null","2007-07-15","日本歯科麻酔学会雑誌","Journal of Japanese Dental Society of Anesthesiology","Vol.35","No.3","346","353","jpn","true","null","scientific_journal","null","null","null","0386-5835","null","http://ci.nii.ac.jp/naid/10019532863/","null","null","null" "口腔外科手術時の静脈内鎮静法におけるデクスメデトミジンとプロポフォールの比較","口腔外科手術時の静脈内鎮静法におけるデクスメデトミジンとプロポフォールの比較","高石 和美, 金子 美幸, 太田 真弓, 尾上 富太郎, 富岡 重正, 中條 信義","Kazumi Takaishi, 金子 美幸, 太田 真弓, 尾上 富太郎, 富岡 重正, 中條 信義","null","null","null","null","null","2007","日本歯科麻酔学会雑誌","Journal of Japanese Dental Society of Anesthesiology","Vol.35","No.2","218","223","jpn","true","null","scientific_journal","null","null","null","0386-5835","null","null","null","null","null" "抜管直後に喘鳴を呈した1症例","抜管直後に喘鳴を呈した1症例","富岡 重正, 高石 和美","Shigemasa Tomioka, Kazumi Takaishi","null","null","null","null","null","2007","臨床麻酔","臨床麻酔","Vol.31","No.11","1785","1786","jpn","true","null","scientific_journal","null","null","null","null","null","null","null","null","null" "熱中症と悪性症候群の既往をもつ知的障害者の全身麻酔経験","熱中症と悪性症候群の既往をもつ知的障害者の全身麻酔経験","高石 和美, 中條 信義","Kazumi Takaishi, Nobuyoshi Nakajo","null","null","null","null","null","2007","麻酔","Masui","Vol.56","No.9","1078","1080","jpn","true","null","scientific_journal","null","null","null","0021-4892","null","null","null","null","null" "全身麻酔中に短時間の停電に遭遇した経験","全身麻酔中に短時間の停電に遭遇した経験","高石 和美, 尾上 富太郎, 富岡 重正, 中條 信義","Kazumi Takaishi, 尾上 富太郎, Shigemasa Tomioka, Nobuyoshi Nakajo","null","null","null","null","null","2007","日本歯科麻酔学会雑誌","Journal of Japanese Dental Society of Anesthesiology","Vol.35","No.1","68","69","jpn","true","null","scientific_journal","null","null","null","0386-5835","null","null","null","null","null" "歯学部学生と卒直後歯科医師に対する救急蘇生教育後の知識およびアンケート調査","歯学部学生と卒直後歯科医師に対する救急蘇生教育後の知識およびアンケート調査","高石 和美, 富岡 重正, 中條 信義","Kazumi Takaishi, Shigemasa Tomioka, Nobuyoshi Nakajo","null","null","null","null","null","2006","日本歯科麻酔学会雑誌","Journal of Japanese Dental Society of Anesthesiology","Vol.34","No.1","39","44","jpn","true","null","scientific_journal","null","null","null","0386-5835","null","null","null","null","null" "全身麻酔時に不整脈を呈した高校生スポーツ選手の麻酔経験","[Anesthetic management of a teenage athlete who developed arrhythmia during general anesthesia].","大下 修弘, 高石 和美, 江口 覚, 張 剛太, 富岡 重正, 中條 信義","大下 修弘, Kazumi Takaishi, Satoru Eguchi, 張 剛太, Shigemasa Tomioka, Nobuyoshi Nakajo","null","A 17-year-old man with fracture of the mandible underwent open fixation under general anesthesia. He was an athlete of the rugby suffering the fracture in a match. His preoperative physical examinations were normal except for I degrees atrioventricular block on electrocardiogram (ECG). During anesthesia, atrioventricular dissociation and frequent premature ventricular contractions were induced by the stimulation of nasotracheal intubation and the administration of atropine for the reversal of muscle relaxation. We thought the cause of the arrhythmia is the athlete's heart which may be vagotonic and may induce vagal reflex or fatal arrhythmia. This case demonstrates that it is necessary to pay attention to chronotropic action associated with the intubation of nasopharynx, the handling of laryngoscope and the usage of drugs for the anesthetic management of the athlete.","A 17-year-old man with fracture of the mandible underwent open fixation under general anesthesia. He was an athlete of the rugby suffering the fracture in a match. His preoperative physical examinations were normal except for I degrees atrioventricular block on electrocardiogram (ECG). During anesthesia, atrioventricular dissociation and frequent premature ventricular contractions were induced by the stimulation of nasotracheal intubation and the administration of atropine for the reversal of muscle relaxation. We thought the cause of the arrhythmia is the athlete's heart which may be vagotonic and may induce vagal reflex or fatal arrhythmia. This case demonstrates that it is necessary to pay attention to chronotropic action associated with the intubation of nasopharynx, the handling of laryngoscope and the usage of drugs for the anesthetic management of the athlete.","null","null","2005-06","麻酔","Masui","Vol.54","No.6","676","679","jpn","true","null","scientific_journal","null","null","null","0021-4892","null","http://ci.nii.ac.jp/naid/40006796255/","null","null","null" "毛細血管拡張性運動失調症患者の全身麻酔経験","Anesthetic Management of the Patient with Ataxia Telangiectasia","高石 和美, 横井 敬子, 宮城 敦, 上地 智博, 新城 啓和, 中條 信義","Kazumi Takaishi, 横井 敬子, 宮城 敦, 上地 智博, 新城 啓和, Nobuyoshi Nakajo","null","null","null","null","null","2005-01-15","日本歯科麻酔学会雑誌","Journal of Japanese Dental Society of Anesthesiology","Vol.33","No.1","100","101","jpn","true","null","scientific_journal","null","null","null","0386-5835","null","http://ci.nii.ac.jp/naid/10014316158/","null","null","null" "低カリウム血症により心電図異常を認めた糖尿病患者の1例","低カリウム血症により心電図異常を認めた糖尿病患者の1例","大下 修弘, 江口 覚, 湯淺 哲也, 舘原 誠晃, 張 剛太, 高石 和美, 富岡 重正, 中條 信義","大下 修弘, Satoru Eguchi, Tetsuya Yuasa, 舘原 誠晃, 張 剛太, Kazumi Takaishi, Shigemasa Tomioka, Nobuyoshi Nakajo","null","null","null","null","null","2005-01-15","日本歯科麻酔学会雑誌","Journal of Japanese Dental Society of Anesthesiology","Vol.33","No.1","81","85","jpn","true","null","scientific_journal","null","null","null","0386-5835","null","http://ci.nii.ac.jp/naid/10014316107/","null","null","null" "家族性にCICR速度亢進を認めた症例","Acceleration of Calcium-induced Calcium Release Rate in a Japanese Family","高石 和美, 富岡 重正, 金子 美幸, 中條 信義","Kazumi Takaishi, Shigemasa Tomioka, Miyuki Kaneko, Nobuyoshi Nakajo","null","null","null","null","null","2005","臨床麻酔","臨床麻酔","Vol.29","No.1","107","109","jpn","true","null","scientific_journal","null","null","null","null","null","null","null","null","null" "過去10年間の外科的矯正手術における体液管理と輸血準備の効率化についての検討","Anaesthetic Study for the Management of Body Fluid and the Efficiency of Preoperative Blood Preparation in Orthognathic Surgery During 10 Years","大下 修弘, 江口 覚, 高石 和美, 張 剛太, 金子 美幸, 富岡 重正, 中條 信義","Naohiro Ohshita, Satoru Eguchi, Kazumi Takaishi, Gota Cho, Miyuki Kaneko, Shigemasa Tomioka, Nobuyoshi Nakajo","null","null","null","null","null","2005","四国歯学会雑誌","Shikoku Dental Research","Vol.17","No.2","243","251","jpn","true","null","scientific_journal","null","null","null","0914-6091","null","http://ci.nii.ac.jp/naid/50000130478/","null","null","null" "徳島大学歯学部付属病院歯科麻酔科外来における過去17年間の臨床統計的観察","Clinico-statistical Observations of Outpatients for Dental Treatment at the Anesthetic Clinic in the Hospital of Tokushima University during a 17-year Period","北岡 栄一郎, 富岡 重正, 大下 修弘, 野村 美幸, 高石 和美, 江口 覚, 中條 信義","北岡 栄一郎, Shigemasa Tomioka, 大下 修弘, 野村 美幸, Kazumi Takaishi, Satoru Eguchi, Nobuyoshi Nakajo","null","null","null","null","null","2003","日本歯科麻酔学会雑誌","Journal of Japanese Dental Society of Anesthesiology","Vol.31","No.3","309","310","jpn","true","null","scientific_journal","null","null","null","0386-5835","null","null","null","null","null" "徳島大学歯学部附属病院歯科麻酔外来における過去17年間の臨床統計的観察","徳島大学歯学部附属病院歯科麻酔外来における過去17年間の臨床統計的観察","北岡 栄一郎, 富岡 重正, 大下 修弘, 野村 美幸, 高石 和美, 江口 覚, 中條 信義","Eiichiro Kitaoka, Shigemasa Tomioka, 大下 修弘, Miyuki Nomura, Kazumi Takaishi, Satoru Eguchi, Nobuyoshi Nakajo","null","null","null","null","null","2003","日本歯科麻酔学会雑誌","Journal of Japanese Dental Society of Anesthesiology","Vol.31","No.3","309","310","jpn","true","null","scientific_journal","null","null","null","0386-5835","null","null","null","null","null" "肝肺症候群患者の抜歯時の全身管理経験","肝肺症候群患者の抜歯時の全身管理経験","野村 美幸, 富岡 重正, 三久 富子, 高石 和美, 中條 信義","野村 美幸, Shigemasa Tomioka, 三久 富子, Kazumi Takaishi, Nobuyoshi Nakajo","null","null","null","null","null","2002-10-15","日本歯科麻酔学会雑誌","Journal of Japanese Dental Society of Anesthesiology","Vol.30","No.5","590","591","jpn","true","null","scientific_journal","null","null","null","0386-5835","null","http://ci.nii.ac.jp/naid/10010316141/","null","null","null" "再生不良性貧血を合併する上顎骨亜全摘術の麻酔経験","Anesthetic Management for a Patient with Aplastic Anemia","三久 富子, 富岡 重正, 高石 和美, 野村 美幸, 中條 信義","Tomiko Mikyu, Shigemasa Tomioka, Kazumi Takaishi, Miyuki Nomura, Nobuyoshi Nakajo","null","null","null","null","null","2002-07","臨床麻酔","臨床麻酔","Vol.26","No.7","1119","1120","jpn","true","null","scientific_journal","null","null","null","null","null","null","null","null","null" "味覚障害患者の治療経験","Treatment of Patients with Dysgeusia","三久 富子, 野村 美幸, 高石 和美, 富岡 重正, 中條 信義","Tomiko Mikyu, Miyuki Nomura, Kazumi Takaishi, Shigemasa Tomioka, Nobuyoshi Nakajo","null","null","null","null","null","2002-01-15","日本歯科麻酔学会雑誌","Journal of Japanese Dental Society of Anesthesiology","Vol.30","No.1","62","68","jpn","true","null","scientific_journal","null","null","null","0386-5835","null","http://ci.nii.ac.jp/naid/10007927863/","null","null","null" "鎮静状態の新しい判定方法を使用した経験","Assessment on the sedative effects using bispectral index","高石 和美, 小積 麻衣子, 飛梅 悟, 古市 幸子, 和田 匡史, 野村 美幸, 三久 富子, 富岡 重正, 中條 信義","Kazumi Takaishi, Maiko Kozumi, Satoru Tobiume, Sachiko Furuichi, Masashi Wada, Miyuki Nomura, Tomiko Mikyu, Shigemasa Tomioka, Nobuyoshi Nakajo","null","null","null","null","null","2002","四国歯学会雑誌","Shikoku Dental Research","Vol.14","No.2","285","292","jpn","true","null","scientific_journal","null","null","null","0914-6091","null","null","null","null","null" "Sturge-Weber 症候群患者の精神鎮静法経験","Sturge-Weber 症候群患者の精神鎮静法経験","高石 和美, 野村 美幸, 大下 修弘, 三久 富子, 江口 覚, 富岡 重正, 中條 信義","Kazumi Takaishi, 野村 美幸, 大下 修弘, 三久 富子, Satoru Eguchi, Shigemasa Tomioka, Nobuyoshi Nakajo","null","null","null","null","null","2001","日本歯科麻酔学会雑誌","Journal of Japanese Dental Society of Anesthesiology","Vol.29","No.5","633","634","jpn","true","null","scientific_journal","null","null","null","0386-5835","null","null","null","null","null" "リドカインの味覚刺激の種類についての検討","リドカインの味覚刺激の種類についての検討","江口 覚, 大下 修弘, 三久 富子, 高石 和美, 富岡 重正, 中條 信義","Satoru Eguchi, 大下 修弘, 三久 富子, Kazumi Takaishi, Shigemasa Tomioka, Nobuyoshi Nakajo","null","null","null","null","null","2000-10-07","第28回 日本歯科麻酔麻酔学会総会","第28回 日本歯科麻酔麻酔学会総会","null","null","null","null","jpn","true","null","scientific_journal","null","null","null","null","null","null","null","null","null" "歯科治療時の静脈内鎮静法における呼気ガスサンプリングチューブNAZORCAPTM の有用性","Usefulness of NAZORCAP(TM) during intravenous sedation with propofol in dentistry","富岡 重正, 大下 修弘, 栗尾 富子, 高石 和美, 江口 覚, 中條 信義","Shigemasa Tomioka, 大下 修弘, 栗尾 富子, Kazumi Takaishi, Satoru Eguchi, Nobuyoshi Nakajo","null","null","null","null","null","2000-04-15","日本歯科麻酔学会雑誌","Journal of Japanese Dental Society of Anesthesiology","Vol.28","No.2","223","226","jpn","true","null","scientific_journal","null","null","null","0386-5835","null","http://ci.nii.ac.jp/naid/10007925770/","null","null","null" "Schwartz-Jampel syndrome 患者の歯科麻酔経験","Schwartz-Jampel syndrome 患者の歯科麻酔経験","大下 修弘, 富岡 重正, 江口 覚, 栗尾 富子, 高石 和美, 中條 信義","大下 修弘, Shigemasa Tomioka, Satoru Eguchi, 栗尾 富子, Kazumi Takaishi, Nobuyoshi Nakajo","null","null","null","null","null","2000-04-15","日本歯科麻酔学会雑誌","Journal of Japanese Dental Society of Anesthesiology","Vol.28","No.2","267","268","jpn","true","null","scientific_journal","null","null","null","0386-5835","null","http://ci.nii.ac.jp/naid/10007925919/","null","null","null" "仔牛大動脈内皮細胞による一酸化窒素産生に与える局所麻酔薬の影響","仔牛大動脈内皮細胞による一酸化窒素産生に与える局所麻酔薬の影響","高石 和美, 中條 信義","Kazumi Takaishi, Nobuyoshi Nakajo","null","null","null","null","null","2000","四国歯学会雑誌","Shikoku Dental Research","Vol.13","No.1","35","47","jpn","true","null","scientific_journal","null","null","null","0914-6091","null","null","null","null","null" "異常絞扼反射に鎮静量以下の低濃度プロポフォールが有効だった症例","異常絞扼反射に鎮静量以下の低濃度プロポフォールが有効だった症例","富岡 重正, 栗尾 富子, 高石 和美, 江口 覚, 中條 信義","富岡 重正, 栗尾 富子, Kazumi Takaishi, 江口 覚, 中條 信義","null","null","null","null","null","1999","日本歯科麻酔学会雑誌","Journal of Japanese Dental Society of Anesthesiology","Vol.27","No.2","189","193","jpn","true","null","scientific_journal","null","null","null","0386-5835","null","null","null","null","null" "悪性高熱症患者2例の遺伝子解析ーナトリウムチャネルαサブユニットエキソン22の関与についてー","悪性高熱症患者2例の遺伝子解析ーナトリウムチャネルαサブユニットエキソン22の関与についてー","富岡 重正, 栗尾 富子, 高石 和美, 江口 覚, 中條 信義","富岡 重正, 栗尾 富子, Kazumi Takaishi, 江口 覚, 中條 信義","null","null","null","null","null","1999","日本歯科麻酔学会雑誌","Journal of Japanese Dental Society of Anesthesiology","Vol.27","No.2","184","188","jpn","true","null","scientific_journal","null","null","null","0386-5835","null","null","null","null","null" "局所麻酔薬が血管内皮細胞へのアルギニン輸送に与える影響","局所麻酔薬が血管内皮細胞へのアルギニン輸送に与える影響","高石 和美, 富岡 重正, 中條 信義","Kazumi Takaishi, Shigemasa Tomioka, Nobuyoshi Nakajo","null","null","null","null","null","1999","日本歯科麻酔学会誌","日本歯科麻酔学会誌","Vol.27","No.3","199","304","jpn","true","null","scientific_journal","null","null","null","null","null","null","null","null","null" "局所麻酔薬が動脈内皮細胞での一酸化窒素に与える影響","局所麻酔薬が動脈内皮細胞での一酸化窒素に与える影響","高石 和美, 富岡 重正, 栗尾 富子, 中條 信義","Kazumi Takaishi, Shigemasa Tomioka, 栗尾 富子, Nobuyoshi Nakajo","null","null","null","null","null","1999","日本歯科麻酔学会雑誌","Journal of Japanese Dental Society of Anesthesiology","Vol.27","No.2","151","157","jpn","true","null","scientific_journal","null","null","null","0386-5835","null","null","null","null","null" "Propofol Is Effective in Chemotherapy-Induced Nausea and Vomiting:A Case Report with Quantitative Analysis","Propofol Is Effective in Chemotherapy-Induced Nausea and Vomiting:A Case Report with Quantitative Analysis","Shigemasa Tomioka, Tomiko Kurio, Kazumi Takaishi, Nobuyoshi Nakajo","Shigemasa Tomioka, Tomiko Kurio, Kazumi Takaishi, Nobuyoshi Nakajo","null","null","null","null","null","1999","the International Anesthesia Research Society","the International Anesthesia Research Society","Vol.89","null","798","799","eng","true","null","scientific_journal","null","null","null","null","null","null","null","null","null" "徳島大学歯学部附属病院歯科麻酔科における過去13年間の全身麻酔症例の検討","徳島大学歯学部附属病院歯科麻酔科における過去13年間の全身麻酔症例の検討","江口 覚, 富岡 重正, 増野 めぐみ, 栗尾 富子, 高石 和美, 中條 信義","江口 覚, 富岡 重正, 増野 めぐみ, 栗尾 富子, Kazumi Takaishi, 中條 信義","null","null","null","null","null","1998","日本歯科麻酔学会雑誌","Journal of Japanese Dental Society of Anesthesiology","Vol.26","No.5","657","664","jpn","true","null","scientific_journal","null","null","null","0386-5835","null","null","null","null","null" "エホバの証人に対する閉鎖循環型自己血輸血回路","エホバの証人に対する閉鎖循環型自己血輸血回路","増野 めぐみ, 岩野 真紀, 江口 覚, 栗尾 富子, 高石 和美, 富岡 重正, 中條 信義","増野 めぐみ, 岩野 真紀, 江口 覚, 栗尾 富子, Kazumi Takaishi, 富岡 重正, 中條 信義","null","null","null","null","null","1997","日本歯科麻酔学会雑誌","Journal of Japanese Dental Society of Anesthesiology","Vol.25","No.2","233","236","jpn","true","null","scientific_journal","null","null","null","0386-5835","null","null","null","null","null" "血管新生に及ぼす麻酔薬と周術期管理法の影響","血管新生に及ぼす麻酔薬と周術期管理法の影響","川人 伸次, 高石 和美, 曽我 朋宏, 北畑 洋","Shinji Kawahito, Kazumi Takaishi, Tomohiro Soga, Hiroshi Kitahata","null","null","null","null","null","2016-10-10","BIO Clinica","BIO Clinica","Vol.33","No.1","1178","1182","jpn","null","null","research_institution","null","null","null","0919-8237","null","null","null","null","null" "レミマゾラムを使用した全静脈麻酔と文献的考察","レミマゾラムを使用した全静脈麻酔と文献的考察","高石 和美","Kazumi Takaishi","null","null","null","null","null","2022","日本歯科麻酔学会Newsletter","日本歯科麻酔学会Newsletter","null","No.103","6","6","jpn","null","null","scientific_journal","null","null","null","null","null","null","null","null","null"