type: misc

label: url

en: Dynamics of Salivary Gland AQP5 under Normal and Pathologic Conditions

en: International Journal of Molecular Sciences


en: Physiological role of a subtilisin-like proprotein convertase, PACE4, in submandibular gland development

en: Journal of Oral Biosciences

ja: Journal of Oral Biosciences


en: Novel members of mammalian Kexin family proteases, PACE4C, PACE4D, PC7A and PC7B.

en: ペプチドホルモンや増殖因子等は不活性な前駆体として合成され, 特定の塩基性アミノ酸部位での限定切断を経て初めて活性化される. Kexin family proteaseはこのプロセシングを担う重要な酵素であり, 本研究では我々が新規メンバーをクローニングし, その構造, 組織分布等を明らかにした.

en: Advances in Experimental Medicine and Biology


en: Molecular mechanism of expression and regulation of water channel, esp. aquaporins in the exocrine gland

ja: 外分泌腺における水チャネル，特にアクアポリン5の発現と機能調節の分子機構

en: , Report of research project, grant in-aid for scientific research (B)

ja: 平成18年度-平成20年度文部省科学研究費補助金(基盤研究(B))研究成果報告書

misc_type: others


en: Induction of inflammation cytokine and defense system of oral cavity: a trial in regeneration medicine

ja: 唾液腺における炎症性サイトカインの誘導と口腔の防御システム:再生医療への試み

en: Report of research project, Grant-in-Aid for Exploratory Research, Tokushima, Mar. 2006

ja: 平成16年度-平成17年度文部省科学研究費補助金(萌芽研究)研究成果報告書


en: Inflammation by mast cell kininogen and its suppression Development of a new drug

ja: 肥満細胞由来キニノーゲンによる炎症とその抑制 -抗アレルギー新薬の開発-

en: , Report of research project, grant in-aid for scientific research (B)(2)

ja: 平成13年度-平成15年度文部省科学研究費補助金(基盤研究(B)(2))研究成果報告書


en: : Expression and regulation of a water channel, aquaporin, in the exocrine gland

ja: 水チャネル蛋白質，アクアポリンの唾液腺細胞における発現と機能調節の分子機構

en: Report of research project, grant in-aid for scientific research (C)(2)

ja: 平成13年度-平成14年度文部省科学研究費補助金(基盤研究(C)(2))研究成果報告書


en: Molecular mechanism of expression and regulation of water channel proteins aquaporins in the salivary gland cells

ja: 水チャネル蛋白質，アクアポリンの唾液腺細胞における発現と機能調節の分子機構

ja: 平成11年度-平成12年度文部省科学研究費補助金(基盤研究(C)(2))研究成果報告書


en: Induced expression of subtilisin-like proprotein convertase in regeneration model of salivary gland

ja: 唾液腺再生モデルにおけるサチライシン様前駆体蛋白質変換酵素の発現誘導


en: Downregulation of AQP2 expression in the kidney of polydipsic STR/N mice

en: Aquaporin-2 (AQP2) is responsible for the concentration of urine in the kidney collecting tubule under the regulation of vasopressin. The mRNA level of this water channel in polydipsic STR/N mice was extremely reduced compared with that in normal ICR mice. In male mice, reduction of the AQP2 mRNA level was not evident at 3 wk of age, at which time water intake was not increased. At 10 wk of age, however, the AQP2 mRNA level was reduced to 10% of that in control mice, whereas water intake was increased by 36%. At 44 wk, the water intake became five times that of the control ICR mice, and the AQP2 mRNA level in these polydipsic mice was only approximately 5% of control. Similar changes were observed in the AQP2 protein level, suggesting that the mRNA level of AQP2 reflects the protein level of AQP2. These inverse changes in the AQP2 mRNA level and water intake were also evident in female mice. The data imply that polydipsia in STR/N mice may have affected AQP2 mRNA transcription in the kidney, resulting in reduced AQP2 expression, which would contribute to a reduction in overretention of water.

en: American Journal of Physiology, Renal Physiology


en: Expression of water channel AQP5 in regeneration model of salivary gland

ja: 唾液腺再生モデルにおける水チャネルAQP5の発現

en: Journal of Oral Biosciences


en: Enhanced ubiquitylation and downregulation of aquaporin-5 by ubiquitin ligases

ja: ユビキチンリガーゼによるAQP5のユビキチン化亢進とダウンレギュレーション


en: Salivary Gland Development, Differentiation, and Regeneration - Role of Subtilisin-like Proprotein Convertase PACE4/SPC4

en: BIT's 1st Annual World Congress of Oral & Dental Medicine Conference Abstract Book


en: The Defense System of Oral Cavity: Lipopolysaccharide Induced Inflammatory Response in the Mice Salivary Gland

ja: BIT's 1st Annual World Congress of Oral & Dental Medicine Conference Abstract Book