=== Generating (published_papers) ===
=== Generating (research_interests) ===
=== Generating (teaching_experience) ===
=== Generating (education) ===
=== Generating (research_experience) ===
=== Generating (misc) ===
=== Generating (research_projects) ===
=== Generating (books_etc) ===
=== Generating (committee_memberships) ===
=== Generating (awards) ===
=== Generating (association_memberships) ===
=== Generating (presentations) ===
==== begin registerFile(/WWW/pub2/data/ERD/person/60376/researchmap/published_papers.jsonl) ====
line:1, {"insert":{"user_id":"1000223301","type":"published_papers","id":"42436046"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/118602","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/36869303","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=397696","label":"url"}],"paper_title":{"en":"Relationships between feeding behaviors and emotions: An electroencephalogram (EEG) frequency analysis study","ja":"Relationships between feeding behaviors and emotions: An electroencephalogram (EEG) frequency analysis study"},"authors":{"en":[{"name":"Kusunoki Shintaroh"},{"name":"Fukuda Takako"},{"name":"Maeda Saori"},{"name":"Yao Chenjuan"},{"name":"Hasegawa Takahiro"},{"name":"Akamatsu Tetsuya"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"楠 進太郎"},{"name":"福田 崇子"},{"name":"前田 さおり"},{"name":"姚 陳娟"},{"name":"長谷川 敬展"},{"name":"赤松 徹也"},{"name":"吉村 弘"}]},"description":{"en":"Feeding behaviors may be easily affected by emotions, both being based on brain activity; however, the relationships between them have not been explicitly defined. In this study, we investigated how emotional environments modulate subjective feelings, brain activity, and feeding behaviors. Electroencephalogram (EEG) recordings were obtained from healthy participants in conditions of virtual comfortable space (CS) and uncomfortable space (UCS) while eating chocolate, and the times required for eating it were measured. We found that the more participants tended to feel comfortable under the CS, the more it took time to eat in the UCS. However, the EEG emergence patterns in the two virtual spaces varied across the individuals. Upon focusing on the theta and low-beta bands, the strength of the mental condition and eating times were found to be guided by these frequency bands. The results determined that the theta and low-beta bands are likely important and relevant waves for feeding behaviors under emotional circumstances, following alterations in mental conditions.","ja":"Feeding behaviors may be easily affected by emotions, both being based on brain activity; however, the relationships between them have not been explicitly defined. In this study, we investigated how emotional environments modulate subjective feelings, brain activity, and feeding behaviors. Electroencephalogram (EEG) recordings were obtained from healthy participants in conditions of virtual comfortable space (CS) and uncomfortable space (UCS) while eating chocolate, and the times required for eating it were measured. We found that the more participants tended to feel comfortable under the CS, the more it took time to eat in the UCS. However, the EEG emergence patterns in the two virtual spaces varied across the individuals. Upon focusing on the theta and low-beta bands, the strength of the mental condition and eating times were found to be guided by these frequency bands. The results determined that the theta and low-beta bands are likely important and relevant waves for feeding behaviors under emotional circumstances, following alterations in mental conditions."},"publication_date":"2022","publication_name":{"en":"The Journal of Physiological Sciences","ja":"The Journal of Physiological Sciences"},"volume":"Vol.73","number":"No.1","starting_page":"2","ending_page":"2","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1186/s12576-022-00858-w"],"issn":["1880-6562"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:2, {"insert":{"user_id":"1000223301","type":"published_papers","id":"39296851"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/34021476","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=387511","label":"url"}],"paper_title":{"en":"Amniotic membrane matrix effects on calcineurin-NFAT-related gene expressions of SHED treated with VEGF for endothelial differentiation.","ja":"Amniotic membrane matrix effects on calcineurin-NFAT-related gene expressions of SHED treated with VEGF for endothelial differentiation."},"authors":{"en":[{"name":"Hashim SNM"},{"name":"Yusof MFH"},{"name":"Zahari W"},{"name":"Noordin KBAA"},{"name":"Akamatsu Tetsuya"},{"name":"Azlina A"}],"ja":[{"name":"Hashim SNM"},{"name":"Yusof MFH"},{"name":"Zahari W"},{"name":"Noordin KBAA"},{"name":"赤松 徹也"},{"name":"Azlina A"}]},"description":{"en":"The nuclear factor of activated T-cell (NFAT) signaling pathway is involved in angiogenesis following initiation by vascular endothelial growth factor (VEGF). A number of angiogenic genes have been associated with calcineurin in the NFAT pathway, forming a calcineurin-NFAT pathway. This study aims to investigate the involvement of four angiogenic genes within the calcineurin-NFAT pathway in the endothelial-like differentiation of stem cells from human exfoliated deciduous teeth (SHED) cultured on a human amniotic membrane (HAM) induced by VEGF. SHED were induced with VEGF for 24 h, then cultured on the stromal side of HAM. The cells were then further induced with VEGF until days 1 and 14. To understand the role of calcineurin, its potent inhibitor, cyclosporin A (CsA), was added into the culture. Results from SEM and H&E analyses showed SHED grew on HAM surface. Gene expression study of Cox-2 showed a drastically reduced expression with CsA treatment indicating Cox-2 involvement in the calcineurin-NFAT pathway. Meanwhile, IL-8 was probably controlled by another pathway as it showed no CsA inhibition. In contrast, high expression of ICAM-1 and RCAN1.4 by VEGF and CsA implied that these genes were not controlled by the calcineurin-NFAT-dependent pathway. In conclusion, the results of this study suggest the involvement of Cox-2 in the calcineurin-NFAT-dependent pathway while RCAN1.4 was controlled by NFAT molecule in endothelial-like differentiation of SHED cultured on HAM with VEGF induction.","ja":"The nuclear factor of activated T-cell (NFAT) signaling pathway is involved in angiogenesis following initiation by vascular endothelial growth factor (VEGF). A number of angiogenic genes have been associated with calcineurin in the NFAT pathway, forming a calcineurin-NFAT pathway. This study aims to investigate the involvement of four angiogenic genes within the calcineurin-NFAT pathway in the endothelial-like differentiation of stem cells from human exfoliated deciduous teeth (SHED) cultured on a human amniotic membrane (HAM) induced by VEGF. SHED were induced with VEGF for 24 h, then cultured on the stromal side of HAM. The cells were then further induced with VEGF until days 1 and 14. To understand the role of calcineurin, its potent inhibitor, cyclosporin A (CsA), was added into the culture. Results from SEM and H&E analyses showed SHED grew on HAM surface. Gene expression study of Cox-2 showed a drastically reduced expression with CsA treatment indicating Cox-2 involvement in the calcineurin-NFAT pathway. Meanwhile, IL-8 was probably controlled by another pathway as it showed no CsA inhibition. In contrast, high expression of ICAM-1 and RCAN1.4 by VEGF and CsA implied that these genes were not controlled by the calcineurin-NFAT-dependent pathway. In conclusion, the results of this study suggest the involvement of Cox-2 in the calcineurin-NFAT-dependent pathway while RCAN1.4 was controlled by NFAT molecule in endothelial-like differentiation of SHED cultured on HAM with VEGF induction."},"publication_date":"2021-05-21","publication_name":{"en":"In Vitro Cellular & Developmental Biology. Animal","ja":"In Vitro Cellular & Developmental Biology. Animal"},"volume":"Vol.57","number":"No.5","starting_page":"560","ending_page":"-570","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s11626-021-00588-0"],"issn":["1543-706X"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:3, {"insert":{"user_id":"1000223301","type":"published_papers","id":"34550659"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116621","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/33137129","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=378259","label":"url"}],"paper_title":{"en":"Bioactivity of alginetin, a caramelization product of pectin: Cytometric analysis of rat thymic lymphocytes using fluorescent probes.","ja":"Bioactivity of alginetin, a caramelization product of pectin: Cytometric analysis of rat thymic lymphocytes using fluorescent probes."},"authors":{"en":[{"name":"Doi Sayaka"},{"name":"Kawamura Mina"},{"name":"Oyama Keisuke"},{"name":"Akamatsu Tetsuya"},{"name":"Mizobuchi Mizuki"},{"name":"Oyama Yasuo"},{"name":"Masuda Toshiya"},{"name":"Kamemura Norio"}],"ja":[{"name":"Doi Sayaka"},{"name":"Kawamura Mina"},{"name":"Oyama Keisuke"},{"name":"赤松 徹也"},{"name":"Mizobuchi Mizuki"},{"name":"小山 保夫"},{"name":"Masuda Toshiya"},{"name":"Kamemura Norio"}]},"description":{"en":"Alginetin is the major product formed from pentoses and hexurionic acids. Alginetin is producted by cooking process of food including pection, a naturally-occurring polysacharride found in many plants. However, the biological interaction and toxicity of alginetin are not known at all. The aim of the present study was to investigate the cellular actions of alginetin on rat thymic lymphocytes. The effects of alginetin on the cell were examined using flow cytometry with fluorescent probes. Alginetin increased cellular content of non-protein thiols ([NPT]i) and elevated intracellular Zn2+ levels ([Zn2+]i). Chelation of intracellular Zn2+ reduced the effect of alginetin on [NPT]i, and chelation of external Zn2+ almost completely diminished alginetin-induced elevation of [Zn2+]i, indicating that alginetin treatment increased Zn2+ influx. Increased [NPT]i and [Zn2+]i levels in response to alginetin were positively correlated. Alginetin protected cells against oxidative stress induced by hydrogen peroxide and Ca2+ overload by calcium ionophore. It is considered that the increases in [NPT]i and [Zn2+]i are responsible for the cytoprotective activity of alginetin because NPT attenuates oxidative stress and Zn2+ competes with Ca2+. Alginetin may be produced during manufacturing of jam, which may provide additional health benefits of jam.","ja":"Alginetin is the major product formed from pentoses and hexurionic acids. Alginetin is producted by cooking process of food including pection, a naturally-occurring polysacharride found in many plants. However, the biological interaction and toxicity of alginetin are not known at all. The aim of the present study was to investigate the cellular actions of alginetin on rat thymic lymphocytes. The effects of alginetin on the cell were examined using flow cytometry with fluorescent probes. Alginetin increased cellular content of non-protein thiols ([NPT]i) and elevated intracellular Zn2+ levels ([Zn2+]i). Chelation of intracellular Zn2+ reduced the effect of alginetin on [NPT]i, and chelation of external Zn2+ almost completely diminished alginetin-induced elevation of [Zn2+]i, indicating that alginetin treatment increased Zn2+ influx. Increased [NPT]i and [Zn2+]i levels in response to alginetin were positively correlated. Alginetin protected cells against oxidative stress induced by hydrogen peroxide and Ca2+ overload by calcium ionophore. It is considered that the increases in [NPT]i and [Zn2+]i are responsible for the cytoprotective activity of alginetin because NPT attenuates oxidative stress and Zn2+ competes with Ca2+. Alginetin may be produced during manufacturing of jam, which may provide additional health benefits of jam."},"publication_date":"2020-11-02","publication_name":{"en":"PLoS ONE","ja":"PLoS ONE"},"volume":"Vol.15","number":"No.11","starting_page":"e0241290","ending_page":"e0241290","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1371/journal.pone.0241290"],"issn":["1932-6203"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:4, {"insert":{"user_id":"1000223301","type":"published_papers","id":"34550660"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116486","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/33096942","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=378258","label":"url"}],"paper_title":{"en":"Citrus sudachi Peel Extract Suppresses Cell Proliferation and Promotes the Differentiation of Keratinocytes through Inhibition of the EGFR-ERK Signaling Pathway.","ja":"Citrus sudachi Peel Extract Suppresses Cell Proliferation and Promotes the Differentiation of Keratinocytes through Inhibition of the EGFR-ERK Signaling Pathway."},"authors":{"en":[{"name":"Abe Shogo"},{"name":"Ueno Misako"},{"name":"Nishitani Mami"},{"name":"Akamatsu Tetsuya"},{"name":"Sato Takumi"},{"name":"Shimoda Marie"},{"name":"Kanaoka Hiroki"},{"name":"Nii Yoshitaka"},{"name":"Yamasaki Hiroko"},{"name":"Yuasa Keizo"}],"ja":[{"name":"安部 庄剛"},{"name":"植野 実佐子"},{"name":"西谷 真美"},{"name":"赤松 徹也"},{"name":"佐藤 匠"},{"name":"Shimoda Marie"},{"name":"Kanaoka Hiroki"},{"name":"Nii Yoshitaka"},{"name":"Yamasaki Hiroko"},{"name":"湯浅 恵造"}]},"publication_date":"2020-10-21","publication_name":{"en":"Biomolecules","ja":"Biomolecules"},"volume":"Vol.10","number":"No.10","starting_page":"1468","ending_page":"1468","languages":["eng"],"referee":true,"identifiers":{"doi":["10.3390/biom10101468"],"issn":["2218-273X"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:5, {"insert":{"user_id":"1000223301","type":"published_papers","id":"34550661"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/27136667","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=332293","label":"url"}],"paper_title":{"en":"Interplay between non-NMDA and NMDA receptor activation during oscillatory wave propagation: Analyses of caffeine-induced oscillations in the visual cortex of rats","ja":"Interplay between non-NMDA and NMDA receptor activation during oscillatory wave propagation: Analyses of caffeine-induced oscillations in the visual cortex of rats"},"authors":{"en":[{"name":"Yoshimura Hiroshi"},{"name":"Tokio Sugai"},{"name":"Nobuo Kato"},{"name":"Takashi Tominaga"},{"name":"Yoko Tominaga"},{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"}],"ja":[{"name":"吉村 弘"},{"name":"Tokio Sugai"},{"name":"Nobuo Kato"},{"name":"Takashi Tominaga"},{"name":"Yoko Tominaga"},{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"}]},"description":{"en":"Generation and propagation of oscillatory activities in cortical networks are important features of the brain. However, many issues related to oscillatory phenomena are unclear. We previously reported neocortical oscillation following caffeine treatment of rat brain slices. Input to the primary visual cortex (Oc1) generates N-methyl-d-aspartate (NMDA) receptor-dependent oscillations, and we proposed that the oscillatory signals originate in the secondary visual cortex (Oc2). Because non-NMDA and NMDA receptors cooperate in synaptic transmission, non-NMDA receptors may also play an important role in oscillatory activities. Here we investigated how non-NMDA receptor activities contribute to NMDA receptor-dependent oscillations by using optical recording methods. After induction of stable oscillations with caffeine application, blockade of NMDA receptors abolished the late stable oscillatory phase, but elicited 'hidden' non-NMDA receptor-dependent oscillation during the early depolarizing phase. An interesting finding is that the origin of the non-NMDA receptor-dependent oscillation moved from the Oc1, during the early phase, toward the origin of the NMDA receptor-dependent oscillation that is fixed in the Oc2. In addition, the frequency of the non-NMDA receptor-dependent oscillation was higher than that of the NMDA receptor-dependent oscillation. Thus, in one course of spatiotemporal oscillatory activities, the relative balance in receptor activities between non-NMDA and NMDA receptors gradually changes, and this may be due to the different kinetics of the two receptor types. These results suggest that interplay between the two receptor types in the areas of Oc1 and Oc2 may play an important role in oscillatory signal communication.","ja":"Generation and propagation of oscillatory activities in cortical networks are important features of the brain. However, many issues related to oscillatory phenomena are unclear. We previously reported neocortical oscillation following caffeine treatment of rat brain slices. Input to the primary visual cortex (Oc1) generates N-methyl-d-aspartate (NMDA) receptor-dependent oscillations, and we proposed that the oscillatory signals originate in the secondary visual cortex (Oc2). Because non-NMDA and NMDA receptors cooperate in synaptic transmission, non-NMDA receptors may also play an important role in oscillatory activities. Here we investigated how non-NMDA receptor activities contribute to NMDA receptor-dependent oscillations by using optical recording methods. After induction of stable oscillations with caffeine application, blockade of NMDA receptors abolished the late stable oscillatory phase, but elicited 'hidden' non-NMDA receptor-dependent oscillation during the early depolarizing phase. An interesting finding is that the origin of the non-NMDA receptor-dependent oscillation moved from the Oc1, during the early phase, toward the origin of the NMDA receptor-dependent oscillation that is fixed in the Oc2. In addition, the frequency of the non-NMDA receptor-dependent oscillation was higher than that of the NMDA receptor-dependent oscillation. Thus, in one course of spatiotemporal oscillatory activities, the relative balance in receptor activities between non-NMDA and NMDA receptors gradually changes, and this may be due to the different kinetics of the two receptor types. These results suggest that interplay between the two receptor types in the areas of Oc1 and Oc2 may play an important role in oscillatory signal communication."},"publication_date":"2016-07","publication_name":{"en":"Neural Networks","ja":"Neural Networks"},"volume":"Vol.79","starting_page":"141","ending_page":"149","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.neunet.2016.03.012"],"issn":["1879-2782"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:6, {"insert":{"user_id":"1000223301","type":"published_papers","id":"34550662"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=320232","label":"url"}],"paper_title":{"en":"Influences of oral impairment on neural oscilltion and wave propagation in the neocortex of rats","ja":"Influences of oral impairment on neural oscilltion and wave propagation in the neocortex of rats"},"authors":{"en":[{"name":"Yoshimura Hiroshi"},{"name":"川邊 真道"},{"name":"須貝 外喜夫"},{"name":"加藤 伸郎"},{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"}],"ja":[{"name":"吉村 弘"},{"name":"川邊 真道"},{"name":"須貝 外喜夫"},{"name":"加藤 伸郎"},{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"}]},"publication_date":"2015-07","publication_name":{"en":"Neuroscience Research Suppl","ja":"Neuroscience Research Suppl"},"volume":"Vol.Suppl","languages":["eng"],"referee":true,"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:7, {"insert":{"user_id":"1000223301","type":"published_papers","id":"25838193"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/24192288","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-84891527146&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=297022","label":"url"}],"paper_title":{"en":"Effects of isoproterenol on aquaporin 5 levels in the parotid gland of mice in vivo.","ja":"Effects of isoproterenol on aquaporin 5 levels in the parotid gland of mice in vivo."},"authors":{"en":[{"name":"Chen Gang"},{"name":"Yao Chenjuan"},{"name":"Hasegawa Takahiro"},{"name":"Akamatsu Tetsuya"},{"name":"Yoshimura Hiroshi"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"陳 剛"},{"name":"姚 陳娟"},{"name":"長谷川 敬展"},{"name":"赤松 徹也"},{"name":"吉村 弘"},{"name":"細井 和雄"}]},"description":{"en":"In the membrane fraction of mouse parotid gland (PG), the protein level of aquaporin 5 (AQP5), a member of the water channel family, was increased by injection (ip) of isoproterenol (IPR), a β-adrenergic agonist, at 1 h, and stayed at high levels until 6 h; this change occurred simultaneously as amylase secretion. The AQP5 level then decreased and returned toward the original level at 12-48 h. After IPR injection, the AQP5 mRNA gradually increased and reached a maximum at 24 h. The facts suggest a rapid appearance of AQP5 at plasma membrane by IPR and subsequent degradation/metabolism by activation of proteolytic systems. Pretreatment of animals with two calpain inhibitors, N-Ac-Leu-Leu-methininal (ALLM) and calpeptin, as well as a protein synthesis inhibitor, cycloheximide (CHX), significantly suppressed the IPR-induced AQP5 degradation in the PG membrane fraction; such suppression was not observed by two proteasome inhibitors, MG132 and lactacystin, or the lysosome denaturant chloroquine, although most of these inhibitors increased AQP5 protein levels in unstimulated mice. The AQP5 protein was also degraded by μ-calpain in vitro. Furthermore, we demonstrated that μ-calpain was colocalized with AQP5 in the acinar cells by immunohistochemistry, and its activity in the PG was increased at 6 h after IPR injection. These results suggest that the calpain system was responsible for IPR-induced AQP5 degradation in the parotid gland and that such a system was coupled to the secretory-restoration cycle of amylase in the PG.","ja":"In the membrane fraction of mouse parotid gland (PG), the protein level of aquaporin 5 (AQP5), a member of the water channel family, was increased by injection (ip) of isoproterenol (IPR), a β-adrenergic agonist, at 1 h, and stayed at high levels until 6 h; this change occurred simultaneously as amylase secretion. The AQP5 level then decreased and returned toward the original level at 12-48 h. After IPR injection, the AQP5 mRNA gradually increased and reached a maximum at 24 h. The facts suggest a rapid appearance of AQP5 at plasma membrane by IPR and subsequent degradation/metabolism by activation of proteolytic systems. Pretreatment of animals with two calpain inhibitors, N-Ac-Leu-Leu-methininal (ALLM) and calpeptin, as well as a protein synthesis inhibitor, cycloheximide (CHX), significantly suppressed the IPR-induced AQP5 degradation in the PG membrane fraction; such suppression was not observed by two proteasome inhibitors, MG132 and lactacystin, or the lysosome denaturant chloroquine, although most of these inhibitors increased AQP5 protein levels in unstimulated mice. The AQP5 protein was also degraded by μ-calpain in vitro. Furthermore, we demonstrated that μ-calpain was colocalized with AQP5 in the acinar cells by immunohistochemistry, and its activity in the PG was increased at 6 h after IPR injection. These results suggest that the calpain system was responsible for IPR-induced AQP5 degradation in the parotid gland and that such a system was coupled to the secretory-restoration cycle of amylase in the PG."},"publication_date":"2014-01","publication_name":{"en":"American Journal of Physiology, Endocrinology and Metabolism","ja":"American Journal of Physiology, Endocrinology and Metabolism"},"volume":"Vol.306","number":"No.1","starting_page":"E100","ending_page":"E108","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1152/ajpendo.00317.2013"],"issn":["1522-1555"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:8, {"insert":{"user_id":"1000223301","type":"published_papers","id":"34550663"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/23517711","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-84884702568&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=281789","label":"url"}],"paper_title":{"en":"Age-dependent emergence of caffeine-assisted voltage oscillations in the endopiriform nucleus of rats.","ja":"Age-dependent emergence of caffeine-assisted voltage oscillations in the endopiriform nucleus of rats."},"authors":{"en":[{"name":"Yoshimura Hiroshi"},{"name":"Sugai Tokio"},{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Kato Nobuo"}],"ja":[{"name":"吉村 弘"},{"name":"須貝 外喜夫"},{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"加藤 伸郎"}]},"description":{"en":"The gustatory insular cortex (IC) is connected with not only the somatosensory cortex, but also the endopiriform nucleus (EPN). We have previously revealed that low-frequency electrical stimulation to the IC can elicit membrane potential oscillations at a frequency of 8-10 Hz in the somatosensory cortex of rat brain slices under bath-application of caffeine. Using the same procedure, we investigated whether the EPN has the ability to generate oscillations, and whether such oscillations emerge age-dependently. Electrical stimulations were delivered to the IC, and field potentials were recorded from the EPN. In the case of slices made from mature rats, stable field potential oscillations at 8-10 Hz were induced in the EPN after repetitive stimulations. Optical recordings revealed that signals traveled from the IC to the EPN by way of the claustrum. Generation of oscillations was N-methyl-d-aspartate (NMDA) receptor activity-dependent, since oscillatory phases disappeared following application of NMDA receptor antagonist. In slices from immature rats, however, oscillations were not induced. IC stimulation can thus age-dependently elicit membrane potential oscillations in the EPN, and the EPN oscillations were NMDA receptor activity-dependent. These findings suggest that developmental changes in properties of the EPN might contribute to development of information integration, including gustatory information.","ja":"The gustatory insular cortex (IC) is connected with not only the somatosensory cortex, but also the endopiriform nucleus (EPN). We have previously revealed that low-frequency electrical stimulation to the IC can elicit membrane potential oscillations at a frequency of 8-10 Hz in the somatosensory cortex of rat brain slices under bath-application of caffeine. Using the same procedure, we investigated whether the EPN has the ability to generate oscillations, and whether such oscillations emerge age-dependently. Electrical stimulations were delivered to the IC, and field potentials were recorded from the EPN. In the case of slices made from mature rats, stable field potential oscillations at 8-10 Hz were induced in the EPN after repetitive stimulations. Optical recordings revealed that signals traveled from the IC to the EPN by way of the claustrum. Generation of oscillations was N-methyl-d-aspartate (NMDA) receptor activity-dependent, since oscillatory phases disappeared following application of NMDA receptor antagonist. In slices from immature rats, however, oscillations were not induced. IC stimulation can thus age-dependently elicit membrane potential oscillations in the EPN, and the EPN oscillations were NMDA receptor activity-dependent. These findings suggest that developmental changes in properties of the EPN might contribute to development of information integration, including gustatory information."},"publication_date":"2013-03-18","publication_name":{"en":"Neuroscience Research","ja":"Neuroscience Research"},"volume":"Vol.76","number":"No.1-2","starting_page":"16","ending_page":"21","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.neures.2013.02.010"],"issn":["1872-8111"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:9, {"insert":{"user_id":"1000223301","type":"published_papers","id":"25838154"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/21868636","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=234766","label":"url"}],"paper_title":{"en":"Induction of Sca-1 via activation of STAT3 system in the duct cells of the mouse submandibular gland by ligation of the main excretory duct","ja":"Induction of Sca-1 via activation of STAT3 system in the duct cells of the mouse submandibular gland by ligation of the main excretory duct"},"authors":{"en":[{"name":"Purwanti, Nunuk"},{"name":"Karabasil, Ratko, Mileva"},{"name":"Matsuo, Shinsuke"},{"name":"Chen Gang"},{"name":"Purevjav Javkhlan"},{"name":"Azlina, Ahmad"},{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Purwanti, Nunuk"},{"name":"Karabasil, Ratko, Mileva"},{"name":"松尾 真介"},{"name":"陳 剛"},{"name":"フルジャフ ジャフラン"},{"name":"Azlina, Ahmad"},{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"細井 和雄"}]},"description":{"en":"To examine the very initial step that takes place immediately after tissue injury and is linked to tissue regeneration, we employed the submandibular gland (SMG), which was injured by ligation of its main excretory duct (MED). Ligation of the MED of the SMG in mice induced the expression of Sca-1, a protein marker of hematopoietic stem cells. In the normal gland, a low level of Sca-1 was expressed, which was localized predominantly in the excretory duct cells. At 1 day after ligation, Sca-1 expression increased prominently in almost all of cells in the duct system, but not in the acinar cells. The level of Sca-1 mRNA had begun to increase at 6 h after ligation and continuously rose thereafter until it reached a plateau, which occurred ∼12 h after ligation. STAT3 phosphorylated at its tyrosine-705 (p-STAT3) in the ligated gland increased immediately after ligation, and it was localized in the nuclei of all duct cells. The results of an EMSA revealed the specific binding of a nuclear extract to the sequence of the γ-interferon activation site (GAS) present in the Sca-1 promoter and confirmed that such binding increased after ligation. Thus the present study suggests that STAT3, having been phosphorylated following MED ligation, was transferred to the nucleus, where it bound to the GAS element in the promoter of Sca-1 gene, resulting in promotion of Sca-1 gene expression. Actual prevention of STAT3 phosphorylation reduced the ligation-induced Sca-1 elevation.","ja":"To examine the very initial step that takes place immediately after tissue injury and is linked to tissue regeneration, we employed the submandibular gland (SMG), which was injured by ligation of its main excretory duct (MED). Ligation of the MED of the SMG in mice induced the expression of Sca-1, a protein marker of hematopoietic stem cells. In the normal gland, a low level of Sca-1 was expressed, which was localized predominantly in the excretory duct cells. At 1 day after ligation, Sca-1 expression increased prominently in almost all of cells in the duct system, but not in the acinar cells. The level of Sca-1 mRNA had begun to increase at 6 h after ligation and continuously rose thereafter until it reached a plateau, which occurred ∼12 h after ligation. STAT3 phosphorylated at its tyrosine-705 (p-STAT3) in the ligated gland increased immediately after ligation, and it was localized in the nuclei of all duct cells. The results of an EMSA revealed the specific binding of a nuclear extract to the sequence of the γ-interferon activation site (GAS) present in the Sca-1 promoter and confirmed that such binding increased after ligation. Thus the present study suggests that STAT3, having been phosphorylated following MED ligation, was transferred to the nucleus, where it bound to the GAS element in the promoter of Sca-1 gene, resulting in promotion of Sca-1 gene expression. Actual prevention of STAT3 phosphorylation reduced the ligation-induced Sca-1 elevation."},"publication_date":"2011-12","publication_name":{"en":"American Journal of Physiology, Gastrointestinal and Liver Physiology","ja":"American Journal of Physiology, Gastrointestinal and Liver Physiology"},"volume":"Vol.301","number":"No.5","starting_page":"G814","ending_page":"G824","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1152/ajpgi.00408.2010"],"issn":["1522-1547"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:10, {"insert":{"user_id":"1000223301","type":"published_papers","id":"26927011"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/21125321","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=213378","label":"url"}],"paper_title":{"en":"Lipopolysaccharide-mediated induction of calprotectin in the submandibular and parotid glands of mice","ja":"Lipopolysaccharide-mediated induction of calprotectin in the submandibular and parotid glands of mice"},"authors":{"en":[{"name":"Javkhlan, Purevjav"},{"name":"Hiroshima Yuka"},{"name":"Azlina, Ahmad"},{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Kido Jun-ichi"},{"name":"Nagata Toshihiko"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Javkhlan, Purevjav"},{"name":"廣島 佑香"},{"name":"Azlina, Ahmad"},{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"木戸 淳一"},{"name":"永田 俊彦"},{"name":"細井 和雄"}]},"description":{"en":"S100A8 and S100A9 constitute a heterodimeric protein, calprotectin. The mRNAs of S100A8 and S100A9, being expressed at minimal levels in the submandibular and parotid glands (SMG and PG, respectively) of C3H/HeN mice, were induced strongly and transiently by lipopolysaccharide (LPS). Among the mRNAs of members of the S100 protein family examined, those of S100A8 and S100A9 were specifically induced by LPS in the salivary glands. The induction was assumed to be mediated via toll-like receptor 4 (TLR4), since their elevation was limited in C3H/HeJ mice, a TLR4-mutant strain. These proteins became expressed in the granular convoluted tubular cells and striated duct cells in the SMG, and in both acinar and duct cells in the PG (all in the cytoplasm). The salivary calprotectin level was not increased by LPS treatment, implying that elevated calprotectin was not secreted into the saliva and that they may function in microcellular environment of the salivary gland.","ja":"S100A8 and S100A9 constitute a heterodimeric protein, calprotectin. The mRNAs of S100A8 and S100A9, being expressed at minimal levels in the submandibular and parotid glands (SMG and PG, respectively) of C3H/HeN mice, were induced strongly and transiently by lipopolysaccharide (LPS). Among the mRNAs of members of the S100 protein family examined, those of S100A8 and S100A9 were specifically induced by LPS in the salivary glands. The induction was assumed to be mediated via toll-like receptor 4 (TLR4), since their elevation was limited in C3H/HeJ mice, a TLR4-mutant strain. These proteins became expressed in the granular convoluted tubular cells and striated duct cells in the SMG, and in both acinar and duct cells in the PG (all in the cytoplasm). The salivary calprotectin level was not increased by LPS treatment, implying that elevated calprotectin was not secreted into the saliva and that they may function in microcellular environment of the salivary gland."},"publication_date":"2011-12","publication_name":{"en":"Inflammation","ja":"Inflammation"},"volume":"Vol.34","number":"No.6","starting_page":"668","ending_page":"680","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s10753-010-9277-1"],"issn":["1573-2576"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:11, {"insert":{"user_id":"1000223301","type":"published_papers","id":"25838182"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/21633078","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=230036","label":"url"}],"paper_title":{"en":"Novel phosphorylation of aquaporin-5 at its threonine 259 through cAMP signaling","ja":"Novel phosphorylation of aquaporin-5 at its threonine 259 through cAMP signaling"},"authors":{"en":[{"name":"Hasegawa Takahiro"},{"name":"Azlina, Ahmad"},{"name":"Purevjav Javkhlan"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"長谷川 敬展"},{"name":"Azlina, Ahmad"},{"name":"フルジャフ ジャフラン"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"細井 和雄"}]},"description":{"en":"Aquaporin-5 (AQP5), a water channel, plays key roles in salivary secretion. The novel phosphorylation of AQP5 was investigated by using human salivary gland (HSG) cells and mouse salivary glands. In the HSG cells stably transfected with a wild-type mouse AQP5 construct, a protein band immunoreactive with antibody against phosphorylated PKA substrate was detected in the AQP5 immunoprecipitated sample, and its intensity was enhanced by short-term treatment of the cells with 8-bromo-cAMP, forskolin, or phorbol 12-myristate 13-acetate, but not by that with A23187 calcium ionophore. Such enhancement was inhibited in the presence of H-89, a PKA inhibitor. An AQP5 mutant (AQP5-T259A) expressed by transfection of HSG cells was not recognized by anti-phosphorylated PKA substrate antibody, even when the cells were stimulated with the protein kinase activators. Immunoblotting and immunofluorescence studies using a specific antibody detecting AQP5 phosphorylated at its Thr259 demonstrated that AQP5 was rapidly and transiently phosphorylated at the apical membrane of acinar cells in the submandibular and parotid glands after administration of isoproterenol, but not pilocarpine. Furthermore, both AQP5 and AQP5-T259A were constitutively localized at the plasma membrane in HSG cells under the resting and forskolin-stimulated conditions. These results suggest that AQP5 is phosphorylated at its Thr259 by PKA through cAMP, but not Ca(2+), signaling pathways, and that this phosphorylation does not contribute to AQP5 trafficking in the salivary gland cells.","ja":"Aquaporin-5 (AQP5), a water channel, plays key roles in salivary secretion. The novel phosphorylation of AQP5 was investigated by using human salivary gland (HSG) cells and mouse salivary glands. In the HSG cells stably transfected with a wild-type mouse AQP5 construct, a protein band immunoreactive with antibody against phosphorylated PKA substrate was detected in the AQP5 immunoprecipitated sample, and its intensity was enhanced by short-term treatment of the cells with 8-bromo-cAMP, forskolin, or phorbol 12-myristate 13-acetate, but not by that with A23187 calcium ionophore. Such enhancement was inhibited in the presence of H-89, a PKA inhibitor. An AQP5 mutant (AQP5-T259A) expressed by transfection of HSG cells was not recognized by anti-phosphorylated PKA substrate antibody, even when the cells were stimulated with the protein kinase activators. Immunoblotting and immunofluorescence studies using a specific antibody detecting AQP5 phosphorylated at its Thr259 demonstrated that AQP5 was rapidly and transiently phosphorylated at the apical membrane of acinar cells in the submandibular and parotid glands after administration of isoproterenol, but not pilocarpine. Furthermore, both AQP5 and AQP5-T259A were constitutively localized at the plasma membrane in HSG cells under the resting and forskolin-stimulated conditions. These results suggest that AQP5 is phosphorylated at its Thr259 by PKA through cAMP, but not Ca(2+), signaling pathways, and that this phosphorylation does not contribute to AQP5 trafficking in the salivary gland cells."},"publication_date":"2011-09","publication_name":{"en":"American Journal of Physiology, Cell Physiology","ja":"American Journal of Physiology, Cell Physiology"},"volume":"Vol.301","number":"No.3","starting_page":"C667","ending_page":"C678","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1152/ajpcell.00058.2011"],"issn":["1522-1563"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:12, {"insert":{"user_id":"1000223301","type":"published_papers","id":"25911431"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/21884259","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=221544","label":"url"}],"paper_title":{"en":"Induction of Sca-1 in the duct cells of the mouse submandibular gland by obstruction of the main excretory duct","ja":"Induction of Sca-1 in the duct cells of the mouse submandibular gland by obstruction of the main excretory duct"},"authors":{"en":[{"name":"Purwanti, Nunuk"},{"name":"Tsuji Daisuke"},{"name":"Azlina, Ahmad"},{"name":"Karabasil, Ratko, Mileva"},{"name":"Javkhlan, Purevjav"},{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Itou Kouji"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Purwanti, Nunuk"},{"name":"辻 大輔"},{"name":"Azlina, Ahmad"},{"name":"Karabasil, Ratko, Mileva"},{"name":"Javkhlan, Purevjav"},{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"伊藤 孝司"},{"name":"細井 和雄"}]},"description":{"en":"The effect of ligation of the main excretory duct (MED) of the mouse submandibular gland (SMG) on the expression of Sca-1, a stem cell antigen, was examined by Western blotting and immunohistochemistry. By Western blotting, the expression of Sca-1 with a molecular weight of 18 kDa was identified in the normal gland. At 1 day post-ligation, the expression level of Sca-1 was strongly increased in the experimental gland and weakly in the contralateral gland, and such expression in both glands decreased at 6 days. By immunohistochemistry, Sca-1 was detected weakly in the apical membrane of excretory duct (ED) cells of the SMG under the normal condition. By duct ligation, Sca-1 became expressed strongly in most cells of the two major duct systems, i.e., the striated duct (SD) and granular convoluted tubules (GCT), but was not detected in the acinar (Ac) cells. By fluorescence-activated cell sorter (FACS) analysis, the number of side population (SP) cells in this gland was found to be increased by ligation. These results imply that Sca-1-positive cells may have a role in the duct cell proliferation in the regeneration step elicited by MED ligation-induced injury.","ja":"The effect of ligation of the main excretory duct (MED) of the mouse submandibular gland (SMG) on the expression of Sca-1, a stem cell antigen, was examined by Western blotting and immunohistochemistry. By Western blotting, the expression of Sca-1 with a molecular weight of 18 kDa was identified in the normal gland. At 1 day post-ligation, the expression level of Sca-1 was strongly increased in the experimental gland and weakly in the contralateral gland, and such expression in both glands decreased at 6 days. By immunohistochemistry, Sca-1 was detected weakly in the apical membrane of excretory duct (ED) cells of the SMG under the normal condition. By duct ligation, Sca-1 became expressed strongly in most cells of the two major duct systems, i.e., the striated duct (SD) and granular convoluted tubules (GCT), but was not detected in the acinar (Ac) cells. By fluorescence-activated cell sorter (FACS) analysis, the number of side population (SP) cells in this gland was found to be increased by ligation. These results imply that Sca-1-positive cells may have a role in the duct cell proliferation in the regeneration step elicited by MED ligation-induced injury."},"publication_date":"2011-09","publication_name":{"en":"Journal of Oral Pathology & Medicine","ja":"Journal of Oral Pathology & Medicine"},"volume":"Vol.40","number":"No.8","starting_page":"651","ending_page":"658","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1111/j.1600-0714.2011.01011.x"],"issn":["1600-0714"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:13, {"insert":{"user_id":"1000223301","type":"published_papers","id":"25838184"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/21138418","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=219834","label":"url"}],"paper_title":{"en":"Effects of naturally occurring G103D point mutation of AQP5 on its water permeability, trafficking, and cellular localization in the submandibular gland of rats","ja":"Effects of naturally occurring G103D point mutation of AQP5 on its water permeability, trafficking, and cellular localization in the submandibular gland of rats"},"authors":{"en":[{"name":"Karabasil, Ratko, Mileva"},{"name":"Hasegawa Takahiro"},{"name":"Azlina, Ahmad"},{"name":"Purwanti, Nunuk"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Tomioka Shigemasa"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Karabasil, Ratko, Mileva"},{"name":"長谷川 敬展"},{"name":"Azlina, Ahmad"},{"name":"Purwanti, Nunuk"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"富岡 重正"},{"name":"細井 和雄"}]},"description":{"en":"AQPs (aquaporins) are water channel proteins that are expressed in almost all living things. In mammalians, 13 members of AQPs (AQP0-12) have been identified so far. AQP5 is known to be expressed mostly in the exocrine cells, including the salivary gland acinar cells. A naturally occurring point mutation (G308A, Gly103 > Asp103) was earlier found in the rat AQP5 gene [Murdiastuti, Purwanti, Karabasil, Li, Yao, Akamatsu, Kanamori and Hosoi (2006) Am. J. Physiol. 291, G1081-G1088]; in this mutant, the rate of initial saliva secretion under stimulated and unstimulated conditions is less than that for the wt (wild-type) animals. Here the mutant molecule was characterized in detail. Using the Xenopus oocyte system, we demonstrated the mutant AQP5 to have water permeability almost the same as that of the wt molecule. Mutant and wt AQP5s, tagged with GFP (green fluorescent protein; GFP-AQP5s) and expressed in polarized MDCK-II (Madin-Darby canine kidney II) cells, first appeared in the vesicular structure(s) in the cytoplasm, and were translocated to the upper plasma membrane or apical membrane during cultivation, with the mutant GFP-AQP5 being translocated less efficiently. Thapsigargin and H-89 both induced translocation in vitro of either molecule, whereas colchicine inhibited this activity; the fraction of cells showing apical localization of mutant GFP-AQP5 was less than that showing that of the wt molecule under any of the experimental conditions used. In the mutant SMG (submandibular gland) tissue, localization of AQP5 in the apical membrane of acinar cells was extremely reduced. Vesicular structures positive for AQP5 and present in the cytoplasm of the acinar cells were co-localized with LAMP2 (lysosome-associated membrane protein 2) or cathepsin D in the mutant gland, whereas such co-localizations were very rare in the wt gland, suggesting that the mutant molecules largely entered lysosomes for degradation. Replacement of highly conserved hydrophobic Gly103 with strongly hydrophilic Asp103 in rat AQP5, though it did not affect water permeability, may possibly have resulted in less efficient membrane trafficking and increased lysosomal degradation, leading to its lower expression in the apical membrane of the acinar cells in the SMG.","ja":"AQPs (aquaporins) are water channel proteins that are expressed in almost all living things. In mammalians, 13 members of AQPs (AQP0-12) have been identified so far. AQP5 is known to be expressed mostly in the exocrine cells, including the salivary gland acinar cells. A naturally occurring point mutation (G308A, Gly103 > Asp103) was earlier found in the rat AQP5 gene [Murdiastuti, Purwanti, Karabasil, Li, Yao, Akamatsu, Kanamori and Hosoi (2006) Am. J. Physiol. 291, G1081-G1088]; in this mutant, the rate of initial saliva secretion under stimulated and unstimulated conditions is less than that for the wt (wild-type) animals. Here the mutant molecule was characterized in detail. Using the Xenopus oocyte system, we demonstrated the mutant AQP5 to have water permeability almost the same as that of the wt molecule. Mutant and wt AQP5s, tagged with GFP (green fluorescent protein; GFP-AQP5s) and expressed in polarized MDCK-II (Madin-Darby canine kidney II) cells, first appeared in the vesicular structure(s) in the cytoplasm, and were translocated to the upper plasma membrane or apical membrane during cultivation, with the mutant GFP-AQP5 being translocated less efficiently. Thapsigargin and H-89 both induced translocation in vitro of either molecule, whereas colchicine inhibited this activity; the fraction of cells showing apical localization of mutant GFP-AQP5 was less than that showing that of the wt molecule under any of the experimental conditions used. In the mutant SMG (submandibular gland) tissue, localization of AQP5 in the apical membrane of acinar cells was extremely reduced. Vesicular structures positive for AQP5 and present in the cytoplasm of the acinar cells were co-localized with LAMP2 (lysosome-associated membrane protein 2) or cathepsin D in the mutant gland, whereas such co-localizations were very rare in the wt gland, suggesting that the mutant molecules largely entered lysosomes for degradation. Replacement of highly conserved hydrophobic Gly103 with strongly hydrophilic Asp103 in rat AQP5, though it did not affect water permeability, may possibly have resulted in less efficient membrane trafficking and increased lysosomal degradation, leading to its lower expression in the apical membrane of the acinar cells in the SMG."},"publication_date":"2011-01","publication_name":{"en":"Biology of the Cell","ja":"Biology of the Cell"},"volume":"Vol.103","number":"No.2","starting_page":"69","ending_page":"86","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1042/BC20100086"],"issn":["1768-322X"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:14, {"insert":{"user_id":"1000223301","type":"published_papers","id":"25838186"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/20689061","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=219833","label":"url"}],"paper_title":{"en":"Roles of lysosomal proteolytic systems in AQP5 degradation in the submandibular gland of rats following chorda tympani parasympathetic denervation","ja":"Roles of lysosomal proteolytic systems in AQP5 degradation in the submandibular gland of rats following chorda tympani parasympathetic denervation"},"authors":{"en":[{"name":"Azlina, Ahmad"},{"name":"Javkhlan, Purevjav"},{"name":"Hiroshima Yuka"},{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Azlina, Ahmad"},{"name":"Javkhlan, Purevjav"},{"name":"廣島 佑香"},{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"細井 和雄"}]},"description":{"en":"Chorda tympani denervation (CTD) of rats was earlier shown to result in loss of submandibular gland (SMG) weight (at only 1 wk) and in continued reduction in aquaporin 5 (AQP5) protein expression (until 4 wk), without affecting its mRNA synthesis (Li X, Azlina A, Karabasil MR, Purwanti N, Hasegawa T, Yao C, Akamatsu T, Hosoi K. Am J Physiol Gastrointest Liver Physiol 295: G112-G123, 2008). The present study indicated that despite elevation of bax, a proapoptosis protein, by CTD, the operation also increased the level of bcl-2, an antiapoptosis protein, in the SMG. Terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL assay) showed no increase in the number of apoptotic cells in the SMG. CTD, however, induced strongly and transiently (at 1-3 days) the protein expression of LC3B-II, a marker protein of autophagosomes, suggesting that the reduction in the gland weight was due to onset of autophagy by CTD. Upon CTD, Lamp2, a lysosomal marker, gradually increased in amount, reaching a peak at the 14th day. Immunohistochemical analysis revealed an increase in the number of lysosome-like structures positive for both AQP5 and Lamp2 in the acinar cells of the SMG after CTD; similar changes were observed also for AQP5 and LC3Bs. These data suggest that AQP5 in the SMG entered autophagosomes and/or lysosomes for degradation upon CTD. In vitro AQP5-degrading activity was found in the SMG extracts, and such activity was shown to be increased by CTD. Inhibitor experiments implied cathepsins B and L to be candidate enzymes for this degradation under normal and CTD conditions, respectively.","ja":"Chorda tympani denervation (CTD) of rats was earlier shown to result in loss of submandibular gland (SMG) weight (at only 1 wk) and in continued reduction in aquaporin 5 (AQP5) protein expression (until 4 wk), without affecting its mRNA synthesis (Li X, Azlina A, Karabasil MR, Purwanti N, Hasegawa T, Yao C, Akamatsu T, Hosoi K. Am J Physiol Gastrointest Liver Physiol 295: G112-G123, 2008). The present study indicated that despite elevation of bax, a proapoptosis protein, by CTD, the operation also increased the level of bcl-2, an antiapoptosis protein, in the SMG. Terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL assay) showed no increase in the number of apoptotic cells in the SMG. CTD, however, induced strongly and transiently (at 1-3 days) the protein expression of LC3B-II, a marker protein of autophagosomes, suggesting that the reduction in the gland weight was due to onset of autophagy by CTD. Upon CTD, Lamp2, a lysosomal marker, gradually increased in amount, reaching a peak at the 14th day. Immunohistochemical analysis revealed an increase in the number of lysosome-like structures positive for both AQP5 and Lamp2 in the acinar cells of the SMG after CTD; similar changes were observed also for AQP5 and LC3Bs. These data suggest that AQP5 in the SMG entered autophagosomes and/or lysosomes for degradation upon CTD. In vitro AQP5-degrading activity was found in the SMG extracts, and such activity was shown to be increased by CTD. Inhibitor experiments implied cathepsins B and L to be candidate enzymes for this degradation under normal and CTD conditions, respectively."},"publication_date":"2010-11","publication_name":{"en":"American Journal of Physiology, Gastrointestinal and Liver Physiology","ja":"American Journal of Physiology, Gastrointestinal and Liver Physiology"},"volume":"Vol.299","number":"No.5","starting_page":"G1106","ending_page":"G1117","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1152/ajpgi.00194.2010"],"issn":["1522-1547"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:15, {"insert":{"user_id":"1000223301","type":"published_papers","id":"25838187"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/20522648","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=213355","label":"url"}],"paper_title":{"en":"Potential down-regulation of salivary gland AQP5 by LPS via cross-coupling of NF-κB and p-c-Jun/c-Fos","ja":"Potential down-regulation of salivary gland AQP5 by LPS via cross-coupling of NF-κB and p-c-Jun/c-Fos"},"authors":{"en":[{"name":"Yao Chenjuan"},{"name":"Purwanti, Nunuk"},{"name":"Karabasil, Ratko, Mileva"},{"name":"Azlina, Ahmad"},{"name":"Purevjav, Javkhlan"},{"name":"Hasegawa Takahiro"},{"name":"Akamatsu Tetsuya"},{"name":"Hosoi, Toru"},{"name":"Ozawa Koichiro"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"姚 陳娟"},{"name":"Purwanti, Nunuk"},{"name":"Karabasil, Ratko, Mileva"},{"name":"Azlina, Ahmad"},{"name":"Purevjav, Javkhlan"},{"name":"長谷川 敬展"},{"name":"赤松 徹也"},{"name":"細井 徹"},{"name":"小澤 孝一郎"},{"name":"細井 和雄"}]},"description":{"en":"The mRNA and protein levels of aquaporin (AQP)5 in the parotid gland were found to be potentially decreased by lipopolysaccharide (LPS) in vivo in C3H/HeN mice, but only weakly in C3H/HeJ, a TLR4 mutant mouse strain. In the LPS-injected mice, pilocarpine-stimulated saliva production was reduced by more than 50%. In a tissue culture system, the LPS-induced decrease in the AQP5 mRNA level was blocked completely by pyrrolidine dithiocarbamate, MG132, tyrphostin AG126, SP600125, and partially by SB203580, which are inhibitors for IkappaB kinase, 26S proteasome, ERK1/2, JNK, and p38 MAPK, respectively. In contrast, the expression of AQP1 mRNA was down-regulated by LPS and such down-regulation was blocked only by SP600125. The transcription factors NF-kappaB (p65 subunit), p-c-Jun, and c-Fos were increased by LPS given in vivo, whereas the protein-binding activities of the parotid gland extract toward the sequences for NF-kappaB but not AP-1-responsive elements present at the promoter region of the AQP5 gene were increased by LPS injection. Co-immunoprecipitation by using antibody columns suggested the physical association of the three transcription factors. These results suggest that LPS-induced potential down-regulation of expression of AQP5 mRNA in the parotid gland is mediated via a complex(es) of these two classes of transcription factors, NF-kappaB and p-c-Jun/c-Fos.","ja":"The mRNA and protein levels of aquaporin (AQP)5 in the parotid gland were found to be potentially decreased by lipopolysaccharide (LPS) in vivo in C3H/HeN mice, but only weakly in C3H/HeJ, a TLR4 mutant mouse strain. In the LPS-injected mice, pilocarpine-stimulated saliva production was reduced by more than 50%. In a tissue culture system, the LPS-induced decrease in the AQP5 mRNA level was blocked completely by pyrrolidine dithiocarbamate, MG132, tyrphostin AG126, SP600125, and partially by SB203580, which are inhibitors for IkappaB kinase, 26S proteasome, ERK1/2, JNK, and p38 MAPK, respectively. In contrast, the expression of AQP1 mRNA was down-regulated by LPS and such down-regulation was blocked only by SP600125. The transcription factors NF-kappaB (p65 subunit), p-c-Jun, and c-Fos were increased by LPS given in vivo, whereas the protein-binding activities of the parotid gland extract toward the sequences for NF-kappaB but not AP-1-responsive elements present at the promoter region of the AQP5 gene were increased by LPS injection. Co-immunoprecipitation by using antibody columns suggested the physical association of the three transcription factors. These results suggest that LPS-induced potential down-regulation of expression of AQP5 mRNA in the parotid gland is mediated via a complex(es) of these two classes of transcription factors, NF-kappaB and p-c-Jun/c-Fos."},"publication_date":"2010-08","publication_name":{"en":"The American Journal of Pathology","ja":"The American Journal of Pathology"},"volume":"Vol.177","number":"No.2","starting_page":"724","ending_page":"734","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2353/ajpath.2010.090282"],"issn":["1525-2191"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:16, {"insert":{"user_id":"1000223301","type":"published_papers","id":"25838189"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/111308","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/19262015","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=186150","label":"url"}],"paper_title":{"en":"Trafficking of GFP-AQP5 chimeric proteins conferred with unphosphorylated amino acids at their PKA-target motif (152SRRTS) in MDCK-II cells","ja":"Trafficking of GFP-AQP5 chimeric proteins conferred with unphosphorylated amino acids at their PKA-target motif (152SRRTS) in MDCK-II cells"},"authors":{"en":[{"name":"Karabasil, Ratko, Mileva"},{"name":"Hasegawa Takahiro"},{"name":"Azlina, Ahmad"},{"name":"Purwanti, Nunuk"},{"name":"Purevjav, Javkhlan"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Karabasil, Ratko, Mileva"},{"name":"長谷川 敬展"},{"name":"Azlina, Ahmad"},{"name":"Purwanti, Nunuk"},{"name":"Purevjav, Javkhlan"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"細井 和雄"}]},"description":{"en":"Three constructs having mutated PKA-target motif at (152)SRRTS of AQP5, an exocrine type water channel, were prepared and fused to C-terminus of green fluorescence protein cDNA to examine the effects of blocking of phosphorylation at (152)SRRTS (a consensus PKA-target motif of AQP5) on translocation or trafficking of the chimeric proteins expressed in the Madin-Darby canine kidney-II (MDCK-II) cells. H-89 treatment increased translocation of wild-type GFP-AQP5 to the apical membrane. All 3 mutant molecules translocated 1.5 to 2 times more than the control wild-type GFP-AQP5. Colchicine but not cytochalasin B inhibited the translocation of wild-type GFP-AQP5. Present results suggest dephosphorylation of this consensus sequence increase GFP-AQP5 translocation, and that microtubules but not microfilaments are involved in this event.","ja":"Three constructs having mutated PKA-target motif at (152)SRRTS of AQP5, an exocrine type water channel, were prepared and fused to C-terminus of green fluorescence protein cDNA to examine the effects of blocking of phosphorylation at (152)SRRTS (a consensus PKA-target motif of AQP5) on translocation or trafficking of the chimeric proteins expressed in the Madin-Darby canine kidney-II (MDCK-II) cells. H-89 treatment increased translocation of wild-type GFP-AQP5 to the apical membrane. All 3 mutant molecules translocated 1.5 to 2 times more than the control wild-type GFP-AQP5. Colchicine but not cytochalasin B inhibited the translocation of wild-type GFP-AQP5. Present results suggest dephosphorylation of this consensus sequence increase GFP-AQP5 translocation, and that microtubules but not microfilaments are involved in this event."},"publication_date":"2009-02","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.56","number":"No.1, 2","starting_page":"55","ending_page":"63","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.56.55"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:17, {"insert":{"user_id":"1000223301","type":"published_papers","id":"25838190"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/19013448","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=186144","label":"url"}],"paper_title":{"en":"Inhibition and transcriptional silencing of a subtilisin-like proprotein convertase, PACE4/SPC4, reduces the branching morphogenesis of and AQP5 expression in rat embryonic submandibular gland","ja":"Inhibition and transcriptional silencing of a subtilisin-like proprotein convertase, PACE4/SPC4, reduces the branching morphogenesis of and AQP5 expression in rat embryonic submandibular gland"},"authors":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Azlina, Ahmad"},{"name":"Purwanti, Nunuk"},{"name":"Karabasil, Ratko, Mileva"},{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"赤松 徹也"},{"name":"Azlina, Ahmad"},{"name":"Purwanti, Nunuk"},{"name":"Karabasil, Ratko, Mileva"},{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"細井 和雄"}]},"description":{"en":"The submandibular gland (SMG) develops through the epithelial-mesenchymal interaction mediated by many growth/differentiation factors including activin and BMPs, which are synthesized as inactive precursors and activated by subtilisin-like proprotein convertases (SPC) following cleavage at their R-X-K/R-R site. Here, we found that Dec-RVKR-CMK, a potent inhibitor of SPC, inhibited the branching morphogenesis of the rat embryonic SMG, and caused low expression of a water channel AQP5, in an organ culture system. Dec-RVKR-CMK also decreased the expression of PACE4, a SPC member, but not furin, another SPC member, suggesting the involvement of PACE4 in the SMG development. Heparin, which is known to translocate PACE4 in the extracellular matrix into the medium, and an antibody specific for the catalytic domain of PACE4, both reduced the branching morphogenesis and AQP5 expression in the SMG. The inhibitory effects of Dec-RVKR-CMK were partially rescued by the addition of recombinant BMP2, whose precursor is one of the candidate substrates for PACE4 in vivo. Further, the suppression of PACE4 expression by siRNAs resulted in decreased expression of AQP5 and inhibition of the branching morphogenesis in the present organ culture system. These observations suggest that PACE4 regulates the SMG development via the activation of some growth/differentiation factors.","ja":"The submandibular gland (SMG) develops through the epithelial-mesenchymal interaction mediated by many growth/differentiation factors including activin and BMPs, which are synthesized as inactive precursors and activated by subtilisin-like proprotein convertases (SPC) following cleavage at their R-X-K/R-R site. Here, we found that Dec-RVKR-CMK, a potent inhibitor of SPC, inhibited the branching morphogenesis of the rat embryonic SMG, and caused low expression of a water channel AQP5, in an organ culture system. Dec-RVKR-CMK also decreased the expression of PACE4, a SPC member, but not furin, another SPC member, suggesting the involvement of PACE4 in the SMG development. Heparin, which is known to translocate PACE4 in the extracellular matrix into the medium, and an antibody specific for the catalytic domain of PACE4, both reduced the branching morphogenesis and AQP5 expression in the SMG. The inhibitory effects of Dec-RVKR-CMK were partially rescued by the addition of recombinant BMP2, whose precursor is one of the candidate substrates for PACE4 in vivo. Further, the suppression of PACE4 expression by siRNAs resulted in decreased expression of AQP5 and inhibition of the branching morphogenesis in the present organ culture system. These observations suggest that PACE4 regulates the SMG development via the activation of some growth/differentiation factors."},"publication_date":"2009-01-15","publication_name":{"en":"Developmental Biology","ja":"Developmental Biology"},"volume":"Vol.325","number":"No.2","starting_page":"434","ending_page":"443","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.ydbio.2008.10.015"],"issn":["1095-564X"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:18, {"insert":{"user_id":"1000223301","type":"published_papers","id":"25838192"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/18450949","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=178424","label":"url"}],"paper_title":{"en":"Degradation of submandibular gland AQP5 by parasympathetic denervation of chorda tympani and its recovery by cevimeline, an M3 muscarinic agonist","ja":"Degradation of submandibular gland AQP5 by parasympathetic denervation of chorda tympani and its recovery by cevimeline, an M3 muscarinic agonist"},"authors":{"en":[{"name":"Li Xuefei"},{"name":"Azlina, Ahmad"},{"name":"Karabasil, Ratko, Mileva"},{"name":"Purwanti, Nunuk"},{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"李 雪飛"},{"name":"Azlina, Ahmad"},{"name":"Karabasil, Ratko, Mileva"},{"name":"Purwanti, Nunuk"},{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"細井 和雄"}]},"description":{"en":"By chorda tympani denervation (CTD, parasympathectomy), the aquaporin 5 (AQP5), but not AQP1, protein level in the rat submandibular gland (SMG) was significantly decreased, dropping to 37% of that of the contralateral gland at 4 wk. The protein levels of AQP5 and AQP1 were not significantly affected by denervation of the cervical sympathetic trunk (sympathectomy). Administration of cevimeline hydrochloride, an M3 muscarinic receptor agonist (10 mg/kg for 7 days po), but not pilocarpine (0.3 mg/kg for 7 days po), recovered the AQP5 protein level reduced by CTD and increased the AQP1 protein level above the control one. The mRNA level of AQP5 was scarcely affected by CTD and cevimeline hydrochloride administration. Administration of chloroquine (50 mg/kg for 7 days po), a denaturant of lysosomes, increased the AQP5 protein level reduced by CTD. An extract obtained from the submandibular lysosomal fraction degraded the AQP5 protein in the total membrane fraction in vitro. These results suggest the possible regulation of the AQP5 protein level in the SMG by the parasympathetic nerves/M3 muscarinic receptor agonist and imply the involvement of lysosomal enzymes, but not a transcriptional mechanism, in this regulation.","ja":"By chorda tympani denervation (CTD, parasympathectomy), the aquaporin 5 (AQP5), but not AQP1, protein level in the rat submandibular gland (SMG) was significantly decreased, dropping to 37% of that of the contralateral gland at 4 wk. The protein levels of AQP5 and AQP1 were not significantly affected by denervation of the cervical sympathetic trunk (sympathectomy). Administration of cevimeline hydrochloride, an M3 muscarinic receptor agonist (10 mg/kg for 7 days po), but not pilocarpine (0.3 mg/kg for 7 days po), recovered the AQP5 protein level reduced by CTD and increased the AQP1 protein level above the control one. The mRNA level of AQP5 was scarcely affected by CTD and cevimeline hydrochloride administration. Administration of chloroquine (50 mg/kg for 7 days po), a denaturant of lysosomes, increased the AQP5 protein level reduced by CTD. An extract obtained from the submandibular lysosomal fraction degraded the AQP5 protein in the total membrane fraction in vitro. These results suggest the possible regulation of the AQP5 protein level in the SMG by the parasympathetic nerves/M3 muscarinic receptor agonist and imply the involvement of lysosomal enzymes, but not a transcriptional mechanism, in this regulation."},"publication_date":"2008-07","publication_name":{"en":"American Journal of Physiology, Gastrointestinal and Liver Physiology","ja":"American Journal of Physiology, Gastrointestinal and Liver Physiology"},"volume":"Vol.295","number":"No.1","starting_page":"G112","ending_page":"G123","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1152/ajpgi.00359.2007"],"issn":["0193-1857"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:19, {"insert":{"user_id":"1000223301","type":"published_papers","id":"23667191"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/17083113","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=147820","label":"url"}],"paper_title":{"en":"Temporospatially regulated expression of subtilisin-like proprotein convertase PACE4 (SPC4) during development of the rat submandibular gland","ja":"Temporospatially regulated expression of subtilisin-like proprotein convertase PACE4 (SPC4) during development of the rat submandibular gland"},"authors":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Purwanti, Nunuk"},{"name":"Karabasil, Ratko, Mileva"},{"name":"Li Xuefei"},{"name":"Yao Chenjuan"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"赤松 徹也"},{"name":"Purwanti, Nunuk"},{"name":"Karabasil, Ratko, Mileva"},{"name":"李 雪飛"},{"name":"姚 陳娟"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"description":{"en":"The temporospatial expression of PACE4, a member of the mammalian subtilisin-like proprotein convertase family involved in the activation of growth/differentiation factors, was investigated by in situ hybridization during the development of the rat submandibular gland (SMG). At the initiation stage (day 15.5 of gestation; E15), PACE4 was intensely expressed in the submandibular epithelium, but weakly expressed in the mesenchymal cells. At E16 when the branching morphogenesis becomes obvious, the expression of PACE4 in the mesenchyme was further decreased, although its level in the submandibular epithelium had not changed remarkably from that at E15. During the next stage of embryonic development (E17-E20), PACE4 was expressed in the cells derived from the submandibular epithelium, which include the proacinar, terminal tubular, and presumptive ductal cells. In the perinatal SMG, PACE4 was still expressed intensely in the terminal portion of the SMG containing the proacinar and terminal tubular cells, whereas its expression in the ductal cells was obviously decreased at the second postnatal day (P2) and at P6. Acinar cells expressing no PACE4 appeared, and their numbers increased following their development (P9-P20). At P30 when the PACE4 expression in the acinar cells was completely suppressed, its expression in the ductal cells became intense again. This temporospatially regulated expression of PACE4 suggests its apparent association with the proliferation, differentiation, and establishment of functional acinar and ductal cells of the SMG.","ja":"The temporospatial expression of PACE4, a member of the mammalian subtilisin-like proprotein convertase family involved in the activation of growth/differentiation factors, was investigated by in situ hybridization during the development of the rat submandibular gland (SMG). At the initiation stage (day 15.5 of gestation; E15), PACE4 was intensely expressed in the submandibular epithelium, but weakly expressed in the mesenchymal cells. At E16 when the branching morphogenesis becomes obvious, the expression of PACE4 in the mesenchyme was further decreased, although its level in the submandibular epithelium had not changed remarkably from that at E15. During the next stage of embryonic development (E17-E20), PACE4 was expressed in the cells derived from the submandibular epithelium, which include the proacinar, terminal tubular, and presumptive ductal cells. In the perinatal SMG, PACE4 was still expressed intensely in the terminal portion of the SMG containing the proacinar and terminal tubular cells, whereas its expression in the ductal cells was obviously decreased at the second postnatal day (P2) and at P6. Acinar cells expressing no PACE4 appeared, and their numbers increased following their development (P9-P20). At P30 when the PACE4 expression in the acinar cells was completely suppressed, its expression in the ductal cells became intense again. This temporospatially regulated expression of PACE4 suggests its apparent association with the proliferation, differentiation, and establishment of functional acinar and ductal cells of the SMG."},"publication_date":"2007-01","publication_name":{"en":"Developmental Dynamics","ja":"Developmental Dynamics"},"volume":"Vol.236","number":"No.1","starting_page":"314","ending_page":"320","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1002/dvdy.21008"],"issn":["1058-8388"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:20, {"insert":{"user_id":"1000223301","type":"published_papers","id":"23667192"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/16901987","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=144775","label":"url"}],"paper_title":{"en":"A naturally occurring point mutation in the rat aquaporin 5 gene, influencing its protein production by and secretion of water from salivary glands","ja":"A naturally occurring point mutation in the rat aquaporin 5 gene, influencing its protein production by and secretion of water from salivary glands"},"authors":{"en":[{"name":"Murdiastuti, Kwartarini"},{"name":"Purwanti, Nunuk"},{"name":"Karabasil, Ratko, Mileva"},{"name":"Li Xuefei"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Murdiastuti, Kwartarini"},{"name":"Purwanti, Nunuk"},{"name":"Karabasil, Ratko, Mileva"},{"name":"李 雪飛"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"description":{"en":"A greater than twofold diversity in the expression level of aquaporin 5 (AQP5) has been observed in the membrane fraction of the submandibular gland (SMG) in Sprague-Dawley rats (Murdiastuti K, Miki O, Yao C, Parvin MN, Kosugi-Tanaka C, Akamatsu T, Kanamori N, and Hosoi K. Pflügers Arch 445: 405-412, 2002). In the present study, breeding between brother and sister rats was repeated within high AQP5 producers and low ones to obtain inbred offspring. High- and low-producer rats from 3rd to 18th generations were used for experiments. By Western blotting, levels of AQP5 proteins in the parotid and lacrimal glands, and lungs were all low in low producers, whereas they were all high in high producers, implying genetic variations of the gene for this water channel. Despite this implication, AQP5 mRNA levels were almost the same between the two groups by Northern blotting, suggesting the irrelevance of transcriptional regulation for this diversity. AQP5 cDNAs from the SMGs of the two groups were sequenced. The nucleotide sequence of AQP5 cDNA from low producers indicated the existence of a point mutation at nt 308 (G308A), leading to a replacement of (103)Gly with (103)Asp in the third transmembrane domain, but no alteration was detected in the Kozak area. The existence of such a mutation was confirmed by the assessment of genomic DNA also. This mutation may have resulted in an abnormal membrane insertion or ineffective trafficking of AQP5, since the rats having this mutation showed extremely low membrane expression of AQP5 in the SMG acinar cells and decreased water secretion from their salivary glands.","ja":"A greater than twofold diversity in the expression level of aquaporin 5 (AQP5) has been observed in the membrane fraction of the submandibular gland (SMG) in Sprague-Dawley rats (Murdiastuti K, Miki O, Yao C, Parvin MN, Kosugi-Tanaka C, Akamatsu T, Kanamori N, and Hosoi K. Pflügers Arch 445: 405-412, 2002). In the present study, breeding between brother and sister rats was repeated within high AQP5 producers and low ones to obtain inbred offspring. High- and low-producer rats from 3rd to 18th generations were used for experiments. By Western blotting, levels of AQP5 proteins in the parotid and lacrimal glands, and lungs were all low in low producers, whereas they were all high in high producers, implying genetic variations of the gene for this water channel. Despite this implication, AQP5 mRNA levels were almost the same between the two groups by Northern blotting, suggesting the irrelevance of transcriptional regulation for this diversity. AQP5 cDNAs from the SMGs of the two groups were sequenced. The nucleotide sequence of AQP5 cDNA from low producers indicated the existence of a point mutation at nt 308 (G308A), leading to a replacement of (103)Gly with (103)Asp in the third transmembrane domain, but no alteration was detected in the Kozak area. The existence of such a mutation was confirmed by the assessment of genomic DNA also. This mutation may have resulted in an abnormal membrane insertion or ineffective trafficking of AQP5, since the rats having this mutation showed extremely low membrane expression of AQP5 in the SMG acinar cells and decreased water secretion from their salivary glands."},"publication_date":"2006-12","publication_name":{"en":"American Journal of Physiology, Gastrointestinal and Liver Physiology","ja":"American Journal of Physiology, Gastrointestinal and Liver Physiology"},"volume":"Vol.291","number":"No.6","starting_page":"GI1081","ending_page":"GI1088","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1152/ajpgi.00449.2005"],"issn":["0193-1857"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:21, {"insert":{"user_id":"1000223301","type":"published_papers","id":"23667193"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/16603260","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=134066","label":"url"}],"paper_title":{"en":"Protein kinase A-regulated membrane trafficking of a green fluorescent protein-aquaporin 5 chimera in MDCK cells","ja":"Protein kinase A-regulated membrane trafficking of a green fluorescent protein-aquaporin 5 chimera in MDCK cells"},"authors":{"en":[{"name":"Kosugi Chisato"},{"name":"Li Xuefei"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"小杉 知里"},{"name":"李 雪飛"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"description":{"en":"The green fluorescent protein (GFP) of the jellyfish, Aeqorea victoria, was used as an autofluorescent tag to track the trafficking of aquaporin 5 (AQP5), an exocrine gland-type water channel. Two groups of chimeric proteins were constructed; one in which GFP was fused to the amino-terminus of AQP5 (GFP-AQP5) and the other, in which it was fused to the carboxyl terminus of it (AQP5-GFP). In each group, 2 chimeras were produced, a wild-type AQP5 with its normal sequence and a mutant AQP5 having a mutated amino acid at 259, i.e., GFP-AQP5-T259A and AQP5-GFP-T259A. They were used to transfect Madin-Darby canine kidney (MDCK) cells. The GFP-AQP5 chimera was localized in the intracellular vesicles, which trafficked to the plasma membrane in response to N(6), 2'-O-dibutyryladenosine 3', 5'-cyclic monophosphate (dbcAMP). Membrane trafficking was inhibited by N-[2-(p-bromocinnamylamino)ethyl]-5-isoquimolinesulfonamide (H-89) but not by palmitoyl-dl-carnitine chloride (PCC). In contrast, the AQP5-GFP chimera expressed in MDCK cells was localized constitutively on the plasma membrane. The cellular localization of the latter chimera was not affected by stimulation with dbcAMP in the presence or absence of H-89 or PCC. Replacement of Thr-259 with Ala-259 did not affect the dbcAMP-induced translocation of the chimeric protein, suggesting that phosphorylation of Thr-259 was not necessary for AQP5 trafficking under the present experimental conditions. Thus, the GFP-AQP5 chimera will be a useful tool to study AQP5 trafficking in vitro, whereas the constitutive membrane localization of the AQP5-GFP chimera suggests the importance of the carboxyl terminus of the AQP5 protein for its sorting, whether it is translocated to intracellular vesicles or to the plasma membrane.","ja":"The green fluorescent protein (GFP) of the jellyfish, Aeqorea victoria, was used as an autofluorescent tag to track the trafficking of aquaporin 5 (AQP5), an exocrine gland-type water channel. Two groups of chimeric proteins were constructed; one in which GFP was fused to the amino-terminus of AQP5 (GFP-AQP5) and the other, in which it was fused to the carboxyl terminus of it (AQP5-GFP). In each group, 2 chimeras were produced, a wild-type AQP5 with its normal sequence and a mutant AQP5 having a mutated amino acid at 259, i.e., GFP-AQP5-T259A and AQP5-GFP-T259A. They were used to transfect Madin-Darby canine kidney (MDCK) cells. The GFP-AQP5 chimera was localized in the intracellular vesicles, which trafficked to the plasma membrane in response to N(6), 2'-O-dibutyryladenosine 3', 5'-cyclic monophosphate (dbcAMP). Membrane trafficking was inhibited by N-[2-(p-bromocinnamylamino)ethyl]-5-isoquimolinesulfonamide (H-89) but not by palmitoyl-dl-carnitine chloride (PCC). In contrast, the AQP5-GFP chimera expressed in MDCK cells was localized constitutively on the plasma membrane. The cellular localization of the latter chimera was not affected by stimulation with dbcAMP in the presence or absence of H-89 or PCC. Replacement of Thr-259 with Ala-259 did not affect the dbcAMP-induced translocation of the chimeric protein, suggesting that phosphorylation of Thr-259 was not necessary for AQP5 trafficking under the present experimental conditions. Thus, the GFP-AQP5 chimera will be a useful tool to study AQP5 trafficking in vitro, whereas the constitutive membrane localization of the AQP5-GFP chimera suggests the importance of the carboxyl terminus of the AQP5 protein for its sorting, whether it is translocated to intracellular vesicles or to the plasma membrane."},"publication_date":"2006-04","publication_name":{"en":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","ja":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"},"volume":"Vol.1763","number":"No.4","starting_page":"337","ending_page":"344","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.bbamcr.2006.02.005"],"issn":["0167-4889"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:22, {"insert":{"user_id":"1000223301","type":"published_papers","id":"23667194"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/16423834","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=132634","label":"url"}],"paper_title":{"en":"Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1b in the submandibular gland of mice","ja":"Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1b in the submandibular gland of mice"},"authors":{"en":[{"name":"Yao Chenjuan"},{"name":"Karabasil, Ratko, Mileva"},{"name":"Purwanti, Nunuk"},{"name":"Li Xuefei"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"姚 陳娟"},{"name":"Karabasil, Ratko, Mileva"},{"name":"Purwanti, Nunuk"},{"name":"李 雪飛"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"description":{"en":"By using Western blot analysis, high levels of 17.5- and 20-kDa interleukin-1beta (IL-1beta) proteins were detected in the submandibular gland (SMG) of mice. Despite this fact, the amount of pro-IL-1beta protein, a precursor of IL-1beta, with a molecular size of 35 kDa in this tissue was below the detectable level, although strong expression of pro-IL-1beta mRNA was observed. A large amount of 17.5-kDa IL-1beta also appeared in the saliva of mice injected with lipopolysaccharide, suggesting that this IL-1beta is a secretory form produced by the SMG. The protein for IL-1beta-converting enzyme, a processing enzyme for pro-IL-1beta, was expressed only at a low level in the SMG as compared with its level in various epithelial tissues or lipopolysaccharide-stimulated macrophages. On the other hand, mK1, mK9, mK13, and mK22, members of the kallikrein family, were detected strongly in the SMG but not in other tissues. By incubation with mK13, but not with mK1, mK9, or mK22, the 35-kDa pro-IL-1beta was cleaved into two major products with molecular masses of 17.5 and 22 kDa, and production was inhibited by phenylmethylsulfonyl fluoride, a serine protease inhibitor, but not by IL-1beta-converting enzyme inhibitors. A peptide segment corresponding to amino acid residues 107-121 of mouse pro-IL-1beta (107WDDDDNLLVCDVPIR) was cleaved by incubation with mK13, generating two peptides, 107WDDDDNL and 114LVCDVPIR. Therefore, kallikrein mK13 would appear to hydrolyze pro-IL-1beta between its Leu113 and Leu114 residues. The results of immunohistochemistry and an autonomic therapy experiment showed that IL-1beta and kallikrein mK13 were co-localized in the secretory granules of granular convoluted tubular cells. Our present results thus suggest kallikrein mK13 is a plausible candidate for the processing enzyme for pro-IL-1beta in the SMG of mice.","ja":"By using Western blot analysis, high levels of 17.5- and 20-kDa interleukin-1beta (IL-1beta) proteins were detected in the submandibular gland (SMG) of mice. Despite this fact, the amount of pro-IL-1beta protein, a precursor of IL-1beta, with a molecular size of 35 kDa in this tissue was below the detectable level, although strong expression of pro-IL-1beta mRNA was observed. A large amount of 17.5-kDa IL-1beta also appeared in the saliva of mice injected with lipopolysaccharide, suggesting that this IL-1beta is a secretory form produced by the SMG. The protein for IL-1beta-converting enzyme, a processing enzyme for pro-IL-1beta, was expressed only at a low level in the SMG as compared with its level in various epithelial tissues or lipopolysaccharide-stimulated macrophages. On the other hand, mK1, mK9, mK13, and mK22, members of the kallikrein family, were detected strongly in the SMG but not in other tissues. By incubation with mK13, but not with mK1, mK9, or mK22, the 35-kDa pro-IL-1beta was cleaved into two major products with molecular masses of 17.5 and 22 kDa, and production was inhibited by phenylmethylsulfonyl fluoride, a serine protease inhibitor, but not by IL-1beta-converting enzyme inhibitors. A peptide segment corresponding to amino acid residues 107-121 of mouse pro-IL-1beta (107WDDDDNLLVCDVPIR) was cleaved by incubation with mK13, generating two peptides, 107WDDDDNL and 114LVCDVPIR. Therefore, kallikrein mK13 would appear to hydrolyze pro-IL-1beta between its Leu113 and Leu114 residues. The results of immunohistochemistry and an autonomic therapy experiment showed that IL-1beta and kallikrein mK13 were co-localized in the secretory granules of granular convoluted tubular cells. Our present results thus suggest kallikrein mK13 is a plausible candidate for the processing enzyme for pro-IL-1beta in the SMG of mice."},"publication_date":"2006-03","publication_name":{"en":"The Journal of Biological Chemistry","ja":"The Journal of Biological Chemistry"},"volume":"Vol.281","number":"No.12","starting_page":"7968","ending_page":"7976","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1074/jbc.M507705200"],"issn":["0021-9258"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:23, {"insert":{"user_id":"1000223301","type":"published_papers","id":"23667173"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/16162270","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=121653","label":"url"}],"paper_title":{"en":"Lipopolysaccharide-induced elevation and secretion of Interleukin-1b in the submandibular gland of male mice","ja":"Lipopolysaccharide-induced elevation and secretion of Interleukin-1b in the submandibular gland of male mice"},"authors":{"en":[{"name":"Yao Chenjuan"},{"name":"Li Xuefei"},{"name":"Kwartarini Murdiastuti"},{"name":"Kosugi Chisato"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"姚 陳娟"},{"name":"李 雪飛"},{"name":"Kwartarini Murdiastuti"},{"name":"小杉 知里"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"description":{"en":"The intraperitoneal injection of lipopolysaccharide (LPS) (400 microg/kg body weight) induced the expression of mRNAs of inflammatory cytokines such as interleukin (IL)-1beta, IL-6 and tumour necrosis factor (TNF)-alpha in the submandibular gland (SMG) of C3H/HeN mice but not that of C3H/HeJ mice, a mutant strain for Toll-like receptor-4 (TLR-4(-) mutant). The mRNA levels of these cytokines in the SMG of the wild-type mice increased as early as 3 hr after injection, peaked at 3-6 hr, and had decreased again by 24 hr. In this study, we particularly focused on IL-1beta, and induction by this endotoxin was investigated in detail. Denervation of the superior cervical trunk and chorda tympani nerve did not diminish the LPS-induced elevation of IL-1beta mRNA in the SMG, indicating the irrelevance of the central nervous system in this induction. TLR-4 mRNA and protein were shown to be strongly expressed in the SMG, suggesting the direct action of LPS on this gland. IL-1beta proteins were localized in the secretory granules of granular convoluted tubular (GCT) cells, and their molecular weights in the gland were 17.5 and 20 kDa. IL-1beta of the same size appeared in the saliva 6 hr after LPS injection in C3H/HeN but not in C3H/HeJ mice. The present study thus suggests that IL-1beta, an inflammation cytokine, is induced and secreted into the saliva in response to endotoxin injected intraperitoneally.","ja":"The intraperitoneal injection of lipopolysaccharide (LPS) (400 microg/kg body weight) induced the expression of mRNAs of inflammatory cytokines such as interleukin (IL)-1beta, IL-6 and tumour necrosis factor (TNF)-alpha in the submandibular gland (SMG) of C3H/HeN mice but not that of C3H/HeJ mice, a mutant strain for Toll-like receptor-4 (TLR-4(-) mutant). The mRNA levels of these cytokines in the SMG of the wild-type mice increased as early as 3 hr after injection, peaked at 3-6 hr, and had decreased again by 24 hr. In this study, we particularly focused on IL-1beta, and induction by this endotoxin was investigated in detail. Denervation of the superior cervical trunk and chorda tympani nerve did not diminish the LPS-induced elevation of IL-1beta mRNA in the SMG, indicating the irrelevance of the central nervous system in this induction. TLR-4 mRNA and protein were shown to be strongly expressed in the SMG, suggesting the direct action of LPS on this gland. IL-1beta proteins were localized in the secretory granules of granular convoluted tubular (GCT) cells, and their molecular weights in the gland were 17.5 and 20 kDa. IL-1beta of the same size appeared in the saliva 6 hr after LPS injection in C3H/HeN but not in C3H/HeJ mice. The present study thus suggests that IL-1beta, an inflammation cytokine, is induced and secreted into the saliva in response to endotoxin injected intraperitoneally."},"publication_date":"2005-10","publication_name":{"en":"Immunology","ja":"Immunology"},"volume":"Vol.116","number":"No.2","starting_page":"213","ending_page":"222","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1111/j.1365-2567.2005.02212.x"],"issn":["0019-2805"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:24, {"insert":{"user_id":"1000223301","type":"published_papers","id":"23667174"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/15650134","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=115761","label":"url"}],"paper_title":{"en":"Subcellular redistribution of AQP5 by vasoactive intestinal polypeptide (VIP) in the Brunner's gland of the rat duodenum","ja":"Subcellular redistribution of AQP5 by vasoactive intestinal polypeptide (VIP) in the Brunner's gland of the rat duodenum"},"authors":{"en":[{"name":"Parvin Nahid Most"},{"name":"Kurabuchi, Shingo"},{"name":"Murdiastuti, Kwartarini"},{"name":"Yao Chenjuan"},{"name":"Kosugi Chisato"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Parvin Nahid Most"},{"name":"倉淵 真悟"},{"name":"Murdiastuti, Kwartarini"},{"name":"姚 陳娟"},{"name":"小杉 知里"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"description":{"en":"Aquaporin (AQP)5, an exocrine-type water channel, was detected in the rat duodenum by Western blot analysis, and was localized by immunohistochemistry in the secretory granule membranes as well as in the apical and lateral aspects of the plasma membrane of Brunner's gland cells. Incubation of duodenal slices with vasoactive intestinal polypeptide (VIP) in vitro significantly increased the amount of AQP5 in the apical membrane fraction in a dose- and time-dependent manner with the amount reaching a plateau at 100 nM VIP and becoming near maximal after a 30-s incubation. Protein kinase inhibitors, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7, 50 muM), and N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89; PKA-specific, 1 muM) blocked this increase, but PKC-specific inhibitor calphostin C did not, implying the involvement of PKA but not PKC in this cellular event. Intravenous injection with VIP (40 mug/kg body wt) provoked dilation of the lumen of the Brunner's gland at 2 and 7 min and increased the staining intensity of AQP5 in the apical and lateral membranes. AQP1 (both nonglycosylated and glycosylated forms) was also found to localize in the apical and basolateral membranes of cells of Brunner's gland. VIP, however, did not provoke any significant change in the AQP1 level in the apical membrane, as judged from the results of the above in vitro and in vivo experiments. These results suggest that VIP induced the exocytosis of granule contents and simultaneously caused translocation of AQP5 but not of AQP1 to the apical membrane in Brunner's gland cells.","ja":"Aquaporin (AQP)5, an exocrine-type water channel, was detected in the rat duodenum by Western blot analysis, and was localized by immunohistochemistry in the secretory granule membranes as well as in the apical and lateral aspects of the plasma membrane of Brunner's gland cells. Incubation of duodenal slices with vasoactive intestinal polypeptide (VIP) in vitro significantly increased the amount of AQP5 in the apical membrane fraction in a dose- and time-dependent manner with the amount reaching a plateau at 100 nM VIP and becoming near maximal after a 30-s incubation. Protein kinase inhibitors, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7, 50 muM), and N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89; PKA-specific, 1 muM) blocked this increase, but PKC-specific inhibitor calphostin C did not, implying the involvement of PKA but not PKC in this cellular event. Intravenous injection with VIP (40 mug/kg body wt) provoked dilation of the lumen of the Brunner's gland at 2 and 7 min and increased the staining intensity of AQP5 in the apical and lateral membranes. AQP1 (both nonglycosylated and glycosylated forms) was also found to localize in the apical and basolateral membranes of cells of Brunner's gland. VIP, however, did not provoke any significant change in the AQP1 level in the apical membrane, as judged from the results of the above in vitro and in vivo experiments. These results suggest that VIP induced the exocytosis of granule contents and simultaneously caused translocation of AQP5 but not of AQP1 to the apical membrane in Brunner's gland cells."},"publication_date":"2005-06","publication_name":{"en":"American Journal of Physiology, Gastrointestinal and Liver Physiology","ja":"American Journal of Physiology, Gastrointestinal and Liver Physiology"},"volume":"Vol.288","number":"No.6","starting_page":"G1283","ending_page":"G1291","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1152/ajpgi.00030.2004"],"issn":["0193-1857"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:25, {"insert":{"user_id":"1000223301","type":"published_papers","id":"23667175"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/12838423","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=72392","label":"url"}],"paper_title":{"en":"Expression and localization of aquaporins, members of the water channel family, during development of the rat submandibular gland.","ja":"Expression and localization of aquaporins, members of the water channel family, during development of the rat submandibular gland."},"authors":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Parvin, Nahid Most"},{"name":"Murdiastuti, Kwartarini"},{"name":"Kosugi Chisato"},{"name":"Yao Chenjuan"},{"name":"Miki, Osamu"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"赤松 徹也"},{"name":"Parvin, Nahid Most"},{"name":"Murdiastuti, Kwartarini"},{"name":"小杉 知里"},{"name":"姚 陳娟"},{"name":"Miki, Osamu"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"description":{"en":"The expression and localization of aquaporins (AQP1-AQP5), members of the water channel family, in the developing rat submandibular gland were analysed using RT-PCR, Northern blotting and immunohistochemistry to explore their relation to the development of this salivary gland. RT-PCR analysis revealed unique expression patterns of each AQP. AQP1 was expressed constitutively during prenatal development, whereas the expression of AQP5 became more intense in the course of development from embryonic day 16.5 (E16) to E20. These expression patterns concurred with the results of Northern blot analysis. AQP3 and AQP4 mRNAs in the prenatal development were not detected in Northern blots, although they were detected by RT-PCR. During postnatal development, AQP5 and AQP1 mRNAs were expressed continuously, but no message for AQP3 or AQP4 was detected. AQP2 mRNA was not detected during either prenatal or postnatal development in this tissue. Immunohistochemical studies revealed that AQP5 was first localized at the apical membrane of proacinar cells at E18, and then became clearly distributed at the apical membrane of acinar cells in accordance with the differentiation and establishment of the mature acini. In addition, some vasculature also showed immunoreactivity for AQP5. AQP1 was immunolocalized in the blood vessels, including capillaries, of the gland throughout development. These observations suggest the existence of transcriptional regulation of rat AQP5, which is one of the most probable regulators of saliva production and secretion, during the establishment of the functional submandibular salivary gland.","ja":"ラット顎下腺発生過程でのAQPファミリーの発現を解析した．AQP3,4は胎生期に非常に弱く発現するが，AQP1,5は胎生期から生後を通して発現し続ける．AQP1は血管にのみ局在するのに対して，AQP5は胎生18日の未分化腺房細胞管腔膜への局在以後，分化成熟につれ腺房細胞の他，一部の血管にも局在する．発生過程を通しAQP5が唾液の産生·分泌に中心的役割を果たすと考えられる．"},"publication_date":"2003-06-28","publication_name":{"en":"Pflügers Archiv : European Journal of Physiology","ja":"Pflügers Archiv : European Journal of Physiology"},"volume":"Vol.446","number":"No.6","starting_page":"641","ending_page":"651","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s00424-003-1109-9"],"issn":["0031-6768"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:26, {"insert":{"user_id":"1000223301","type":"published_papers","id":"23667176"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=72225","label":"url"}],"paper_title":{"en":"Divergent expression and localization of aquaporin 5, an exocrine-type water channel, in the submandibular gland of Sprague-Dawley rats.","ja":"Divergent expression and localization of aquaporin 5, an exocrine-type water channel, in the submandibular gland of Sprague-Dawley rats."},"authors":{"en":[{"name":"Murdiastuti Kwartarini"},{"name":"Miki Osamu"},{"name":"Yao Chenjuan"},{"name":"Parvin Nahid Most"},{"name":"Kosugi Chisato"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Murdiastuti Kwartarini"},{"name":"Miki Osamu"},{"name":"姚 陳娟"},{"name":"Parvin Nahid Most"},{"name":"小杉 知里"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"description":{"en":"正常SDラット唾液腺(顎下腺)のAQP5蛋白質発現レベルを調べた所，高発現ラットおよび低発現ラットが存在する事を見いだした．2種のラットを近交化する目的で兄妹交配を進め，現在高発現ラットは8代目に，また低発現ラットは4代目に到った．これらのラットでは発現レベルの差は100倍以上に達した．AQP5蛋白質発現レベルの差は耳下腺，肺，涙腺においても認められたが，AQP5 mRNAレベルはいずれの臓器においても両グループ間で差はなかった．したがって，上記2グループ間で認められたAQP5蛋白質発現レベルの差異はAQP5遺伝子あるいはそのプロモーターに発生した遺伝的変異に基づくものと考えられた．","ja":"正常SDラット唾液腺(顎下腺)のAQP5蛋白質発現レベルを調べた所，高発現ラットおよび低発現ラットが存在する事を見いだした．2種のラットを近交化する目的で兄妹交配を進め，現在高発現ラットは8代目に，また低発現ラットは4代目に到った．これらのラットでは発現レベルの差は100倍以上に達した．AQP5蛋白質発現レベルの差は耳下腺，肺，涙腺においても認められたが，AQP5 mRNAレベルはいずれの臓器においても両グループ間で差はなかった．したがって，上記2グループ間で認められたAQP5蛋白質発現レベルの差異はAQP5遺伝子あるいはそのプロモーターに発生した遺伝的変異に基づくものと考えられた．"},"publication_date":"2002-10","publication_name":{"en":"Pflügers Archiv : European Journal of Physiology","ja":"Pflügers Archiv : European Journal of Physiology"},"volume":"Vol.445","number":"No.3","starting_page":"405","ending_page":"412","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s00424-002-0940-8"],"issn":["0031-6768"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:27, {"insert":{"user_id":"1000223301","type":"published_papers","id":"23667200"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/11853885","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=71860","label":"url"}],"paper_title":{"en":"Expression and localization of AOP5 in the stomach and duodenum of the rat.","ja":"Expression and localization of AOP5 in the stomach and duodenum of the rat."},"authors":{"en":[{"name":"Parvin, Nahid Most"},{"name":"Tsumura Keiko"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Parvin, Nahid Most"},{"name":"津村 恵子"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"description":{"en":"消化管におけるアクアポリン5(AQP5)の発現を，RT-PCRおよびウェッスタンブロッティングによってしらべ，下部胃および十二指腸にその強い発現を認めた．検出したAQP5蛋白質は従来の報告のとおり27kDaであった．発現部位は胃では幽門腺，十二指腸ではブルーナー腺であった．これらの結果はAQP5は胃および十二指腸における水分泌に関与する可能性を示唆する．","ja":"消化管におけるアクアポリン5(AQP5)の発現を，RT-PCRおよびウェッスタンブロッティングによってしらべ，下部胃および十二指腸にその強い発現を認めた．検出したAQP5蛋白質は従来の報告のとおり27kDaであった．発現部位は胃では幽門腺，十二指腸ではブルーナー腺であった．これらの結果はAQP5は胃および十二指腸における水分泌に関与する可能性を示唆する．"},"publication_date":"2002-01-30","publication_name":{"en":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","ja":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"},"volume":"Vol.1542","number":"No.1-3","starting_page":"116","ending_page":"124","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/S0167-4889(01)00172-0"],"issn":["0167-4889"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:28, {"insert":{"user_id":"1000223301","type":"published_papers","id":"23667201"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=71858","label":"url"}],"paper_title":{"en":"Methylene blue as a vascular filling dye.","ja":"Methylene blue as a vascular filling dye."},"authors":{"en":[{"name":"Kanamori Norio"},{"name":"Akamatsu Tetsuya"},{"name":"Kosugi Chisato"},{"name":"Parvin, Nahid Most"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"金森 憲雄"},{"name":"赤松 徹也"},{"name":"小杉 知里"},{"name":"Parvin, Nahid Most"},{"name":"細井 和雄"}]},"description":{"en":"メチレンブルー溶液とピクリン酸溶液とを混合すると，色素の濃度に依存して，ゲル状∼ゴム状の沈澱を生ずることを見出した．この沈殿物を回収してその吸収パターンを計測した結果，メチレンブルーそのものであり，ピクリン酸との化合物や共沈殿物ではないことが判明した．すなわち，ピクリン酸による塩析効果によって色素が沈澱する．ピクリン酸を含むブアン液によって潅流固定した実験動物の血管内にメチレンブルー溶液を注入することにより，生成したゴム状またはゲル状の茶色の色素によって血管内を満たすことができる．通常の色素による染色では，すべての血管が染色され，組織は瀰慢性に濃染してしまう．この新たに開発した方法は，色素濃度を加減することによって生成物の粘性を選ぶことができ，色素進入の血管径を選択できるので，太い血管から順に色素を充填することが可能で，血管網のin situ観察に高い利用価値を有する．","ja":"メチレンブルー溶液とピクリン酸溶液とを混合すると，色素の濃度に依存して，ゲル状∼ゴム状の沈澱を生ずることを見出した．この沈殿物を回収してその吸収パターンを計測した結果，メチレンブルーそのものであり，ピクリン酸との化合物や共沈殿物ではないことが判明した．すなわち，ピクリン酸による塩析効果によって色素が沈澱する．ピクリン酸を含むブアン液によって潅流固定した実験動物の血管内にメチレンブルー溶液を注入することにより，生成したゴム状またはゲル状の茶色の色素によって血管内を満たすことができる．通常の色素による染色では，すべての血管が染色され，組織は瀰慢性に濃染してしまう．この新たに開発した方法は，色素濃度を加減することによって生成物の粘性を選ぶことができ，色素進入の血管径を選択できるので，太い血管から順に色素を充填することが可能で，血管網のin situ観察に高い利用価値を有する．"},"publication_date":"2002-01","publication_name":{"en":"ITE Leters on Batteries, New Technologies & Medicine (with News)","ja":"ITE Leters on Batteries, New Technologies & Medicine (with News)"},"volume":"Vol.3","number":"No.1","starting_page":"75","ending_page":"77","languages":["eng"],"referee":true,"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:29, {"insert":{"user_id":"1000223301","type":"published_papers","id":"23667179"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=71903","label":"url"}],"paper_title":{"en":"Induction of C-reactive protein, serum amyloid P component, and kininogens in the submandibular and lacrimal glands of rats with experimentally induced inflammation.","ja":"Induction of C-reactive protein, serum amyloid P component, and kininogens in the submandibular and lacrimal glands of rats with experimentally induced inflammation."},"authors":{"en":[{"name":"Wei, Wei"},{"name":"Parvin, Nahid Most"},{"name":"Tsumura Keiko"},{"name":"Akamatsu Tetsuya"},{"name":"Tada, Jun"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Wei, Wei"},{"name":"Parvin, Nahid Most"},{"name":"津村 恵子"},{"name":"赤松 徹也"},{"name":"Tada, Jun"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"description":{"en":"テルペンチン油を投与した実験的炎症モデルラットにおいて，投与24時間後に，C-反応生蛋白質，血清アミロイド蛋白質，H-およびT-キニノーゲンのmRNAが，顎下腺，眼窩内および眼窩外涙腺に誘導されることを見いだした．投与6時間後に，この誘導に先立って，TNF-αmRNAが誘導された．顎下腺，眼窩内および眼窩外涙腺におけるこれら急性期蛋白質の誘導は，外分泌腺に強い防御系が存在することを示唆するものと考えられる．","ja":"テルペンチン油を投与した実験的炎症モデルラットにおいて，投与24時間後に，C-反応生蛋白質，血清アミロイド蛋白質，H-およびT-キニノーゲンのmRNAが，顎下腺，眼窩内および眼窩外涙腺に誘導されることを見いだした．投与6時間後に，この誘導に先立って，TNF-αmRNAが誘導された．顎下腺，眼窩内および眼窩外涙腺におけるこれら急性期蛋白質の誘導は，外分泌腺に強い防御系が存在することを示唆するものと考えられる．"},"publication_date":"2001-06","publication_name":{"en":"Life Sciences","ja":"Life Sciences"},"volume":"Vol.69","number":"No.3","starting_page":"359","ending_page":"368","languages":["eng"],"referee":true,"identifiers":{"issn":["0024-3205"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:30, {"insert":{"user_id":"1000223301","type":"published_papers","id":"23667204"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=71878","label":"url"}],"paper_title":{"en":"Expression and locarization of AQP4 in the crypt epithelial cells of the rat duodenum.","ja":"Expression and locarization of AQP4 in the crypt epithelial cells of the rat duodenum."},"authors":{"en":[{"name":"Parvin, Nahid Most"},{"name":"Murdiastuti, Kwartarini"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Maeda, Norihiko"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Parvin, Nahid Most"},{"name":"Murdiastuti, Kwartarini"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"Maeda, Norihiko"},{"name":"細井 和雄"}]},"description":{"en":"RT-PCRによってアクアポリン4(AQP4)の消化管における発現を調べた．AQP4は下部胃，十二指腸，空腸，回腸，盲腸，大腸，および直腸に発現していたが上部胃ニは発現を認めなかった．ウェッスタンブロッティングで十二指腸に30kDaのAQP4蛋白質の発現を認めた．滅め貴組織化学実験によりAQP4は十二指腸上皮の陰窩細胞の基底側膜に局在したが絨毛細胞には局在しなかった．","ja":"RT-PCRによってアクアポリン4(AQP4)の消化管における発現を調べた．AQP4は下部胃，十二指腸，空腸，回腸，盲腸，大腸，および直腸に発現していたが上部胃ニは発現を認めなかった．ウェッスタンブロッティングで十二指腸に30kDaのAQP4蛋白質の発現を認めた．滅め貴組織化学実験によりAQP4は十二指腸上皮の陰窩細胞の基底側膜に局在したが絨毛細胞には局在しなかった．"},"publication_date":"2001-04","publication_name":{"en":"Biomedical Research (India)","ja":"Biomedical Research (India)"},"volume":"Vol.12","number":"No.2","starting_page":"77","ending_page":"82","languages":["eng"],"referee":true,"identifiers":{"issn":["0970-938X"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:31, {"insert":{"user_id":"1000223301","type":"published_papers","id":"23667206"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=71873","label":"url"}],"paper_title":{"en":"Search for the dye that stains the vascular system.","ja":"Search for the dye that stains the vascular system."},"authors":{"en":[{"name":"Kanamori Norio"},{"name":"Akamatsu Tetsuya"},{"name":"Tada, Jun"},{"name":"Tsumura Keiko"},{"name":"Parvin, Nahid Most"},{"name":"Murdiastui, Kwartarini"},{"name":"Wei, Wei"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"金森 憲雄"},{"name":"赤松 徹也"},{"name":"Tada, Jun"},{"name":"津村 恵子"},{"name":"Parvin, Nahid Most"},{"name":"Murdiastui, Kwartarini"},{"name":"Wei, Wei"},{"name":"細井 和雄"}]},"description":{"en":"血管系の，特に動脈系に特異的なin situ染色法を開発する目的で，数種の染料を選び，その染色性その他の諸性質を検討した．いくつかの候補の中から，ルクソールファストブルーが最も望ましい性質を有することを明らかにした．すなわち，同色素溶液はピクリン酸溶液と接触すると複塩または錯塩を生成し，原色素とは異なる吸収曲線を呈する沈澱を生じる．ピクリン酸を含む固定液で潅流したのち左心室より同色素液を注入すると，動脈系だけが染色される．このようなin situ血管染色法は，今までになかったものである．","ja":"血管系の，特に動脈系に特異的なin situ染色法を開発する目的で，数種の染料を選び，その染色性その他の諸性質を検討した．いくつかの候補の中から，ルクソールファストブルーが最も望ましい性質を有することを明らかにした．すなわち，同色素溶液はピクリン酸溶液と接触すると複塩または錯塩を生成し，原色素とは異なる吸収曲線を呈する沈澱を生じる．ピクリン酸を含む固定液で潅流したのち左心室より同色素液を注入すると，動脈系だけが染色される．このようなin situ血管染色法は，今までになかったものである．"},"publication_date":"2001-01","publication_name":{"en":"ITE Leters on Batteries, New Technologies & Medicine (with News)","ja":"ITE Leters on Batteries, New Technologies & Medicine (with News)"},"volume":"Vol.2","number":"No.1","starting_page":"116","ending_page":"119","languages":["eng"],"referee":true,"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:32, {"insert":{"user_id":"1000223301","type":"published_papers","id":"23667181"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/10833428","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-0034616641&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=72135","label":"url"}],"paper_title":{"en":"Highly regulated expression of subtilisin-like proprotein convertase PACE4 (SPC4) during dentinogenesis.","ja":"Highly regulated expression of subtilisin-like proprotein convertase PACE4 (SPC4) during dentinogenesis."},"authors":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Matsuda Yoshiko"},{"name":"Tsumura Keiko"},{"name":"Tada Jun"},{"name":"Parvin Nahid Most"},{"name":"Wei Wei"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"赤松 徹也"},{"name":"松田 佳子"},{"name":"津村 恵子"},{"name":"Tada Jun"},{"name":"Parvin Nahid Most"},{"name":"Wei Wei"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"description":{"en":"Expressions of mRNAs for four subtilisin-like proprotein convertases (SPCs: furin, PACE4, PC6, and PC8) and bone morphogenetic protein 4 (BMP4) in the rat molar tooth during development were analyzed by Northern blotting, reverse transcriptase-polymerase chain reaction (RT-PCR), and in situ hybridization to explore the possible involvement of SPCs in the processing of proBMPs. We found a temporospacial expression of PACE4, but not one of the other SPCs, in this tissue; i.e., RT-PCR analysis revealed that the level of PACE4 mRNA, but not that of the other SPC mRNAs became high around the second postnatal day. This increase was in good accordance with the increase in BMP4 mRNA, indicating an apparent association of these molecules with the differentiation and establishment of functional ameloblasts and odontoblasts. During dentinogenesis, PACE4 mRNA was localized in the ameloblasts and odontoblasts. These observations suggest that PACE4 plays a crucial role in dentinogenesis, especially via the activation of BMPs.","ja":"サチライシン様プロセシング酵素PACE4は遺伝子プロモーター領域の構造から，その発現は極めて複雑に制御されると考えられたが，生体内での発現制御については不明であった．本研究により，歯牙形成過程において実際に発現が複雑に制御されていること，また， この様な発現制御がファミリーの中でもPACE4に特有であることが初めて明らかになった．"},"publication_date":"2000-06-07","publication_name":{"en":"Biochemical and Biophysical Research Communications","ja":"Biochemical and Biophysical Research Communications"},"volume":"Vol.272","number":"No.2","starting_page":"410","ending_page":"415","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1006/bbrc.2000.2752"],"issn":["0006-291X"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:33, {"insert":{"user_id":"1000223301","type":"published_papers","id":"23667207"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/11122457","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-0034537325&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=71904","label":"url"}],"paper_title":{"en":"Expression of kininogens in the connective tissue-type mast cells of the rats.","ja":"Expression of kininogens in the connective tissue-type mast cells of the rats."},"authors":{"en":[{"name":"Hosoi Kazuo"},{"name":"Matsuura, Sachiko"},{"name":"Tsumura Keiko"},{"name":"Wei, Wei"},{"name":"Parvin Nahid Most"},{"name":"Tada, Jun"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Suzuki, Kazuo"}],"ja":[{"name":"細井 和雄"},{"name":"松浦 幸子"},{"name":"津村 恵子"},{"name":"Wei, Wei"},{"name":"Parvin Nahid Most"},{"name":"多田 淳"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"鈴木 和夫"}]},"description":{"en":"The connective tissue-type mast cells present in the submandibular gland (SMG) and peritoneal cavity of rats were found to express kininogens (KGs), the expression of which was demonstrated by Western blotting, reverse transcription-polymerase chain reaction (RT-PCR), RT-PCR Southern blotting, and light- and electron-microscopic immunocytochemistry. In the SMG, the analysis of cDNA amplified by RT-PCR revealed that the molecular species of mRNAs expressed were high-molecular-weight (HMW)-K KG and T-I KG. Light microscopic immunocytochemistry exclusively localized the KG protein(s) in the mast cells present in the SMG. The signals in the mast cells were very strong, but no positive reaction was observed in the granular convoluted tubular cells, acinar cells or striated duct cells. As determined by using electron microscopy, extremely strong labelling with immunogold was observed in the secretory granules of the mast cells, but no labelling in their nucleus or cytoplasm. Analysis by Western blotting and RT-PCR Southern blotting indicated that both protein and mRNA of KGs were present in the mast cells separated from the peritoneal cavity, indicating de novo synthesis of KG in these cells. Preliminary experiments implied that the connective tissue-type mast cells in other rat tissues also expressed KG.","ja":"ラット顎下腺および腹腔に存在する結合組織型肥満細胞にキニノーゲン(KG)が発現していることをRT-PCR，ウェッスタンブロッティング，免疫組織化学的手法を用いて明らかにした．発現しているKGは高分子型およびT-1KGであった．KGは肥満細胞分泌顆粒に局在した．RT-PCRサザンブロッティングにより分離腹腔肥満細胞にKG mRNAを検出したのでKGは肥満細胞でde novoの合成が行われて入ることが示唆された．"},"publication_date":"2000-01","publication_name":{"en":"Immunology","ja":"Immunology"},"volume":"Vol.101","number":"No.4","starting_page":"531","ending_page":"540","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1046/j.1365-2567.2000.00132.x"],"issn":["0019-2805"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:34, {"insert":{"user_id":"1000223301","type":"published_papers","id":"23667209"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=72210","label":"url"}],"paper_title":{"en":"Involvement of vesicle-cytoskeleton interaction in AQP5 trafficking in AQP5-gene-transfected HSG cells.","ja":"Involvement of vesicle-cytoskeleton interaction in AQP5 trafficking in AQP5-gene-transfected HSG cells."},"authors":{"en":[{"name":"Tada Jun"},{"name":"Sawa Takamasa"},{"name":"Yamanaka Naoki"},{"name":"Shono Masayuki"},{"name":"Akamatsu Tetsuya"},{"name":"Tsumura Keiko"},{"name":"Parvin, Nahid Most"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"多田 淳"},{"name":"澤 考賢"},{"name":"山中 直樹"},{"name":"庄野 正行"},{"name":"赤松 徹也"},{"name":"津村 恵子"},{"name":"Parvin, Nahid Most"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"description":{"en":"ヒト唾液腺細胞にアクアポリン5(AQP5)を遺伝子導入したところ，AQP5蛋白質は細胞内の小胞に発現した．タプシガージン等により細胞内カルシウムを上昇させると小胞のAQP5蛋白質は細胞膜へ移動した．さらに微小管阻害剤である，コルヒチンおよびビンブラスチンはこの移動を抑制した．AQP5のトラッフィッキングは微小管が関与して入る可能性が示唆された．","ja":"ヒト唾液腺細胞にアクアポリン5(AQP5)を遺伝子導入したところ，AQP5蛋白質は細胞内の小胞に発現した．タプシガージン等により細胞内カルシウムを上昇させると小胞のAQP5蛋白質は細胞膜へ移動した．さらに微小管阻害剤である，コルヒチンおよびビンブラスチンはこの移動を抑制した．AQP5のトラッフィッキングは微小管が関与して入る可能性が示唆された．"},"publication_date":"1999-12","publication_name":{"en":"Biochemical and Biophysical Research Communications","ja":"Biochemical and Biophysical Research Communications"},"volume":"Vol.266","number":"No.2","starting_page":"443","ending_page":"447","languages":["eng"],"referee":true,"identifiers":{"issn":["0006-291X"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:35, {"insert":{"user_id":"1000223301","type":"published_papers","id":"23667183"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=72039","label":"url"}],"paper_title":{"en":"Subtilisin-like proprotein convertase PACE4 (SPC4) is a candidate processing enzyme of bone morphogenetic proteins during tooth formation","ja":"Subtilisin-like proprotein convertase PACE4 (SPC4) is a candidate processing enzyme of bone morphogenetic proteins during tooth formation"},"authors":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Matsuda Yoshiko"},{"name":"Tsumura Keiko"},{"name":"Tada Jun"},{"name":"Parvin, Nahid Most"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"赤松 徹也"},{"name":"松田 佳子"},{"name":"津村 恵子"},{"name":"多田 淳"},{"name":"Parvin, Nahid Most"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"description":{"en":"サチライシン様プロセシング酵素PACE4が歯牙形成過程において時期·空間特異的に発現し，歯牙形成に必須の骨形成蛋白質群(BMPs)と一致して局在することから， PACE4が歯牙形成時の最も有力なBMPsプロセシング酵素で， BMPsの活性化によりエナメル芽細胞と象牙芽細胞の分化成熟と密接に関わることを見い出した．","ja":"サチライシン様プロセシング酵素PACE4が歯牙形成過程において時期·空間特異的に発現し，歯牙形成に必須の骨形成蛋白質群(BMPs)と一致して局在することから， PACE4が歯牙形成時の最も有力なBMPsプロセシング酵素で， BMPsの活性化によりエナメル芽細胞と象牙芽細胞の分化成熟と密接に関わることを見い出した．"},"publication_date":"1999-12","publication_name":{"en":"Developmental Dynamics","ja":"Developmental Dynamics"},"volume":"Vol.216","number":"No.4/5","starting_page":"481","ending_page":"488","languages":["eng"],"referee":true,"identifiers":{"issn":["1058-8388"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:36, {"insert":{"user_id":"1000223301","type":"published_papers","id":"23667188"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=72164","label":"url"}],"paper_title":{"en":"Genomic organization and alternative splicing of human PACE4 (SPC4), Kexin-like processing endoprotease.","ja":"Genomic organization and alternative splicing of human PACE4 (SPC4), Kexin-like processing endoprotease."},"authors":{"en":[{"name":"Tsuji Akihiko"},{"name":"Hine Chiemi"},{"name":"Tamai Yasuhiro"},{"name":"Yonemoto Kayoko"},{"name":"Mori Kazushige"},{"name":"Yoshida Shigeru"},{"name":"Bando Miwa"},{"name":"Sakai Eri"},{"name":"Mori Kenji"},{"name":"Akamatsu Tetsuya"},{"name":"Matsuda Yoshiko"}],"ja":[{"name":"辻 明彦"},{"name":"Hine Chiemi"},{"name":"Tamai Yasuhiro"},{"name":"Yonemoto Kayoko"},{"name":"Mori Kazushige"},{"name":"Yoshida Shigeru"},{"name":"坂東 美和"},{"name":"Sakai Eri"},{"name":"Mori Kenji"},{"name":"赤松 徹也"},{"name":"松田 佳子"}]},"description":{"en":"本研究ではプロセシング酵素Kexin familyの1つPACE4のヒトゲノムを単離し, その構造を解析し, ファミリーの中でも最も大きく複雑な構造であること, 多種類存在するアイソフォームが全て同一遺伝子から選択的スプライシングにより生じること, およびプロモーター領域がユニークな構造であること等を初めて明らかにした.","ja":"本研究ではプロセシング酵素Kexin familyの1つPACE4のヒトゲノムを単離し, その構造を解析し, ファミリーの中でも最も大きく複雑な構造であること, 多種類存在するアイソフォームが全て同一遺伝子から選択的スプライシングにより生じること, およびプロモーター領域がユニークな構造であること等を初めて明らかにした."},"publication_date":"1997-08","publication_name":{"en":"The Journal of Biochemistry","ja":"The Journal of Biochemistry"},"volume":"Vol.122","number":"No.2","starting_page":"438","ending_page":"452","languages":["eng"],"referee":true,"identifiers":{"issn":["0021-924X"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:37, {"insert":{"user_id":"1000223301","type":"published_papers","id":"34550664"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=72152","label":"url"}],"paper_title":{"en":"Developmental expression of a novel Kexin family protease, PACE4E, in the rat olfactory system.","ja":"Developmental expression of a novel Kexin family protease, PACE4E, in the rat olfactory system."},"authors":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Daikoku Shigeo"},{"name":"Nagamune Hideaki"},{"name":"Yoshida Shigeru"},{"name":"Mori Kenji"},{"name":"Tsuji Akihiko"},{"name":"Matsuda Yoshiko"}],"ja":[{"name":"赤松 徹也"},{"name":"Daikoku Shigeo"},{"name":"長宗 秀明"},{"name":"Yoshida Shigeru"},{"name":"Mori Kenji"},{"name":"辻 明彦"},{"name":"松田 佳子"}]},"description":{"en":"本研究では新規Kexin family proteaseであるPACE4Eがラット脳発生過程において時期·空間特異的に発現することを明らかにし, 特に嗅球においては僧帽細胞に極めて特異的に発現し, 僧帽細胞の分化成熟と密接に関わることを見い出した.","ja":"本研究では新規Kexin family proteaseであるPACE4Eがラット脳発生過程において時期·空間特異的に発現することを明らかにし, 特に嗅球においては僧帽細胞に極めて特異的に発現し, 僧帽細胞の分化成熟と密接に関わることを見い出した."},"publication_date":"1997-08","publication_name":{"en":"Histochemistry and Cell Biology","ja":"Histochemistry and Cell Biology"},"volume":"Vol.108","number":"No.2","starting_page":"95","ending_page":"103","languages":["eng"],"referee":true,"identifiers":{"issn":["0948-6143"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:38, {"insert":{"user_id":"1000223301","type":"published_papers","id":"23667212"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=13168","label":"url"}],"paper_title":{"en":"A Novel Human PACE4 Isoform, PACE4E Is an Active Processing Protease Containing a Hydrophobic Cluster at the Carboxy Terminus","ja":"A Novel Human PACE4 Isoform, PACE4E Is an Active Processing Protease Containing a Hydrophobic Cluster at the Carboxy Terminus"},"authors":{"en":[{"name":"Mori Kenji"},{"name":"Kii Sachiko"},{"name":"Tsuji Akihiko"},{"name":"Nagahama Masami"},{"name":"Imamaki Akiyoshi"},{"name":"Hayashi Keiko"},{"name":"Akamatsu Tetsuya"},{"name":"Nagamune Hideaki"},{"name":"Matsuda Yoshiko"}],"ja":[{"name":"Mori Kenji"},{"name":"Kii Sachiko"},{"name":"辻 明彦"},{"name":"長浜 正巳"},{"name":"Imamaki Akiyoshi"},{"name":"Hayashi Keiko"},{"name":"赤松 徹也"},{"name":"長宗 秀明"},{"name":"松田 佳子"}]},"description":{"en":"ズブチリシン様プロプロテインコンベルターゼファミリーに属するPACE4の新規アイソフォームPACE4E-I, PACE4E-IIをヒト脳cDNAライブラリーよりクローニングした．PACE4Eは，PACE4Aと比べ，C末に75残基からなる，疎水性アミノ酸のクラスタを含むユニークな配列を持っていた．この部分を欠失したPACE4Eは分泌速度が上昇した．共発現実験によって，PACE4E-1, E-IIは，PACE4Aと同様にプロセシング活性を持っていることが証明された．","ja":"ズブチリシン様プロプロテインコンベルターゼファミリーに属するPACE4の新規アイソフォームPACE4E-I, PACE4E-IIをヒト脳cDNAライブラリーよりクローニングした．PACE4Eは，PACE4Aと比べ，C末に75残基からなる，疎水性アミノ酸のクラスタを含むユニークな配列を持っていた．この部分を欠失したPACE4Eは分泌速度が上昇した．共発現実験によって，PACE4E-1, E-IIは，PACE4Aと同様にプロセシング活性を持っていることが証明された．"},"publication_date":"1997-05-01","publication_name":{"en":"The Journal of Biochemistry","ja":"The Journal of Biochemistry"},"volume":"Vol.121","number":"No.5","starting_page":"941","ending_page":"948","referee":true,"identifiers":{"issn":["0021-924X"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:39, {"insert":{"user_id":"1000223301","type":"published_papers","id":"23667215"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=72157","label":"url"}],"paper_title":{"en":"Distribution of the kexin family proteases in pancreatic islets. --- PACE4C is specifically expressed in B cells of pancreatic islets","ja":"Distribution of the kexin family proteases in pancreatic islets. --- PACE4C is specifically expressed in B cells of pancreatic islets"},"authors":{"en":[{"name":"Nagamune Hideaki"},{"name":"Muramatsu Kazuaki"},{"name":"Akamatsu Tetsuya"},{"name":"Tamai Yasuhiro"},{"name":"Izumi Keisuke"},{"name":"Tsuji Akihiko"},{"name":"Matsuda Yoshiko"}],"ja":[{"name":"長宗 秀明"},{"name":"Muramatsu Kazuaki"},{"name":"赤松 徹也"},{"name":"Tamai Yasuhiro"},{"name":"泉 啓介"},{"name":"辻 明彦"},{"name":"松田 佳子"}]},"description":{"en":"Kexin Family Proteasesはペプチドホルモン等のプロセシング酵素として同定され, 血糖調節ホルモンのインスリン等のプロセシングにも関与することが示唆されていたが, 本研究では我々が新規にクローニングしたPACE4CをはじめとするKexin Family Proteasesとインスリン等との膵島細胞での局在, 共存関係を初めて明らかにし, その成果は雑誌表紙にも掲載された.","ja":"Kexin Family Proteasesはペプチドホルモン等のプロセシング酵素として同定され, 血糖調節ホルモンのインスリン等のプロセシングにも関与することが示唆されていたが, 本研究では我々が新規にクローニングしたPACE4CをはじめとするKexin Family Proteasesとインスリン等との膵島細胞での局在, 共存関係を初めて明らかにし, その成果は雑誌表紙にも掲載された."},"publication_date":"1995-01","publication_name":{"en":"Endocrinology","ja":"Endocrinology"},"volume":"Vol.136","number":"No.1","starting_page":"357","ending_page":"360","languages":["eng"],"referee":true,"identifiers":{"issn":["0013-7227"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:40, {"insert":{"user_id":"1000223301","type":"published_papers","id":"23667216"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=72147","label":"url"}],"paper_title":{"en":"Identification of targeting proteinase for rat α1-macroglobulin in vivo. --- Mast-cell tryptase is a major component of the α1-macroglobulin-proteinase complex endocytosed into rat liver lysosomes.","ja":"Identification of targeting proteinase for rat α1-macroglobulin in vivo. --- Mast-cell tryptase is a major component of the α1-macroglobulin-proteinase complex endocytosed into rat liver lysosomes."},"authors":{"en":[{"name":"Tsuji Akihiko"},{"name":"Akamatsu Tetsuya"},{"name":"Nagamune Hideaki"},{"name":"Matsuda Yoshiko"}],"ja":[{"name":"辻 明彦"},{"name":"赤松 徹也"},{"name":"長宗 秀明"},{"name":"松田 佳子"}]},"description":{"en":"血清蛋白質であるα-マクログロブリン(αM)は種々の酵素に対するインヒビターとして機能すると考えられていたが, 生体内で標的となる酵素は不明であった. 本研究ではαMが酵素と複合体形成後, リソゾームに運ばれ分解されることに着目し, リソゾーム内の分解を抑制したラット肝臓リソゾームよりαM-酵素複合体を単離し, 肥満細胞トリプターゼが生体内でαMの標的酵素の1つであることを初めて明らかにした.","ja":"血清蛋白質であるα-マクログロブリン(αM)は種々の酵素に対するインヒビターとして機能すると考えられていたが, 生体内で標的となる酵素は不明であった. 本研究ではαMが酵素と複合体形成後, リソゾームに運ばれ分解されることに着目し, リソゾーム内の分解を抑制したラット肝臓リソゾームよりαM-酵素複合体を単離し, 肥満細胞トリプターゼが生体内でαMの標的酵素の1つであることを初めて明らかにした."},"publication_date":"1994-02","publication_name":{"en":"The Biochemical Journal","ja":"The Biochemical Journal"},"volume":"Vol.298","number":"No.1","starting_page":"79","ending_page":"85","languages":["eng"],"referee":true,"identifiers":{"issn":["0264-6021"]},"published_paper_type":"scientific_journal"},"priority":"input_data"}
line:41, {"insert":{"user_id":"1000223301","type":"published_papers","id":"23667202"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=97551","label":"url"}],"paper_title":{"en":"Structure, function, and transcriptional regulation of aquaporins, proteins of the water channel family","ja":"Structure, function, and transcriptional regulation of aquaporins, proteins of the water channel family"},"authors":{"en":[{"name":"Nahid Parvin Most"},{"name":"Tada Jun"},{"name":"Akamatsu Tetsuya"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Nahid Parvin Most"},{"name":"Tada Jun"},{"name":"赤松 徹也"},{"name":"細井 和雄"}]},"publication_date":"2001-03","publication_name":{"en":"Dentistry in Japan","ja":"Dentistry in Japan"},"volume":"Vol.37","starting_page":"26","ending_page":"31","languages":["eng"],"identifiers":{"issn":["0070-3737"]}},"priority":"input_data"}
line:42, {"insert":{"user_id":"1000223301","type":"published_papers","id":"34550617"},"force":{"see_also":[{"@id":"http://ci.nii.ac.jp/naid/120005823527/","label":"url"},{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/109872","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1050564287418446592/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=329725","label":"url"}],"paper_title":{"en":"Structure and Function of the Salivary Gland","ja":"唾液腺の構造と機能"},"authors":{"en":[{"name":"Akamatsu Tetsuya"}],"ja":[{"name":"赤松 徹也"}]},"description":{"en":"The salivary gland is developed under the epithelial-mesenchymal interaction and formed by repeating branching morphogenesis, which is a common process in the development of the glandular tissues. Although the differentiation and maturation of salivary gland is continued into early postnatal life, the fundamental ability of saliva secretion is already expressed after birth.These development, differentiation, and maturation of salivary gland are regulated by many growth/ differentiation factors, which are initially synthesized as inactive precursors and activated by the limited proteolysis. On the other hand, saliva secretion is one of the important physiological functions of the salivary gland and occurs dependently on the increase of the osmolality in the lumen through two pathways, paracellular and transcellular pathways. It is revealed that a water channel aquaporin 5 (AQP5) is involved in saliva secretion through the latter pathway. Saliva contains various components, which express various physiological functions of saliva. Because the oral cavity is confronted with hazards of various allergens from the outside continuously, the salivary gland produces and secretes various factors as the defense system. Saliva is, therefore, one of an important body fluid to maintain the oral health, and the decrease of saliva secretion causes xerostomia/dry mouth, which affects not only oral disease and dysfunction but also systemic disease. We previously reported the involvement of a subtilisin-like proprotein convertase PACE4 in the development and differentiation of salivary gland, lipopolysaccharide-mediated induction of inflammatory cytokines in the salivary gland, degradation of salivary AQP5 by parasympathetic denervation, and so on. This review will describe the structure and function of the salivary gland, from its development to functional expression and regulation.","ja":"The salivary gland is developed under the epithelial-mesenchymal interaction and formed by repeating branching morphogenesis, which is a common process in the development of the glandular tissues. Although the differentiation and maturation of salivary gland is continued into early postnatal life, the fundamental ability of saliva secretion is already expressed after birth.These development, differentiation, and maturation of salivary gland are regulated by many growth/ differentiation factors, which are initially synthesized as inactive precursors and activated by the limited proteolysis. On the other hand, saliva secretion is one of the important physiological functions of the salivary gland and occurs dependently on the increase of the osmolality in the lumen through two pathways, paracellular and transcellular pathways. It is revealed that a water channel aquaporin 5 (AQP5) is involved in saliva secretion through the latter pathway. Saliva contains various components, which express various physiological functions of saliva. Because the oral cavity is confronted with hazards of various allergens from the outside continuously, the salivary gland produces and secretes various factors as the defense system. Saliva is, therefore, one of an important body fluid to maintain the oral health, and the decrease of saliva secretion causes xerostomia/dry mouth, which affects not only oral disease and dysfunction but also systemic disease. We previously reported the involvement of a subtilisin-like proprotein convertase PACE4 in the development and differentiation of salivary gland, lipopolysaccharide-mediated induction of inflammatory cytokines in the salivary gland, degradation of salivary AQP5 by parasympathetic denervation, and so on. This review will describe the structure and function of the salivary gland, from its development to functional expression and regulation."},"publication_date":"2016-02","publication_name":{"en":"Journal of Oral Health and Biosciences","ja":"Journal of Oral Health and Biosciences"},"volume":"Vol.28","number":"No.2","starting_page":"77","ending_page":"86","languages":["jpn"],"invited":true,"identifiers":{"issn":["2188-7888"]}},"priority":"input_data"}
==== end registerFile(/WWW/pub2/data/ERD/person/60376/researchmap/published_papers.jsonl, ugE6HI8B7kacV6CWvk6C) ====
==== begin registerFile(/WWW/pub2/data/ERD/person/60376/researchmap/misc.jsonl) ====
line:1, {"insert":{"user_id":"1000223301","type":"misc"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/114575","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85079334066&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=363200","label":"url"}],"paper_title":{"en":"Dynamics of Salivary Gland AQP5 under Normal and Pathologic Conditions","ja":"Dynamics of Salivary Gland AQP5 under Normal and Pathologic Conditions"},"authors":{"en":[{"name":"Hosoi Kazuo"},{"name":"Yao Chenjuan"},{"name":"Hasegawa Takahiro"},{"name":"Yoshimura Hiroshi"},{"name":"Akamatsu Tetsuya"}],"ja":[{"name":"細井 和雄"},{"name":"姚 陳娟"},{"name":"長谷川 敬展"},{"name":"吉村 弘"},{"name":"赤松 徹也"}]},"publication_date":"2020-02","publication_name":{"en":"International Journal of Molecular Sciences","ja":"International Journal of Molecular Sciences"},"volume":"Vol.21","number":"No.4","starting_page":"1182","ending_page":"1182","languages":["eng"],"identifiers":{"doi":["10.3390/ijms21041182"],"issn":["1422-0067"]},"misc_type":"introduction_scientific_journal"},"priority":"input_data"}
line:2, {"insert":{"user_id":"1000223301","type":"misc"},"similar_merge":{"see_also":[{"@id":"http://ci.nii.ac.jp/naid/10027105459/","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1390001205213224960/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=226015","label":"url"}],"paper_title":{"en":"Physiological role of a subtilisin-like proprotein convertase, PACE4, in submandibular gland development","ja":"Physiological role of a subtilisin-like proprotein convertase, PACE4, in submandibular gland development"},"authors":{"en":[{"name":"Akamatsu Tetsuya"}],"ja":[{"name":"赤松 徹也"}]},"publication_date":"2010-05-20","publication_name":{"en":"Journal of Oral Biosciences","ja":"Journal of Oral Biosciences"},"volume":"Vol.52","number":"No.2","starting_page":"81","ending_page":"93","languages":["eng"],"invited":true,"identifiers":{"doi":["10.2330/joralbiosci.52.81"],"issn":["1349-0079"]},"misc_type":"introduction_scientific_journal"},"priority":"input_data"}
line:3, {"insert":{"user_id":"1000223301","type":"misc"},"similar_merge":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=72161","label":"url"}],"paper_title":{"en":"Novel members of mammalian Kexin family proteases, PACE4C, PACE4D, PC7A and PC7B.","ja":"Novel members of mammalian Kexin family proteases, PACE4C, PACE4D, PC7A and PC7B."},"authors":{"en":[{"name":"Matsuda Yoshiko"},{"name":"Tsuji Akihiko"},{"name":"Nagamune Hideaki"},{"name":"Akamatsu Tetsuya"},{"name":"Hine Chiemi"},{"name":"Muramatsu Kazuaki"},{"name":"Mori Kenji"},{"name":"Tamai Yasuhiro"},{"name":"Yonemoto Kayoko"}],"ja":[{"name":"松田 佳子"},{"name":"辻 明彦"},{"name":"長宗 秀明"},{"name":"赤松 徹也"},{"name":"Hine Chiemi"},{"name":"Muramatsu Kazuaki"},{"name":"Mori Kenji"},{"name":"Tamai Yasuhiro"},{"name":"Yonemoto Kayoko"}]},"description":{"en":"ペプチドホルモンや増殖因子等は不活性な前駆体として合成され, 特定の塩基性アミノ酸部位での限定切断を経て初めて活性化される. Kexin family proteaseはこのプロセシングを担う重要な酵素であり, 本研究では我々が新規メンバーをクローニングし, その構造, 組織分布等を明らかにした.","ja":"ペプチドホルモンや増殖因子等は不活性な前駆体として合成され, 特定の塩基性アミノ酸部位での限定切断を経て初めて活性化される. Kexin family proteaseはこのプロセシングを担う重要な酵素であり, 本研究では我々が新規メンバーをクローニングし, その構造, 組織分布等を明らかにした."},"publication_date":"1996-09","publication_name":{"en":"Advances in Experimental Medicine and Biology","ja":"Advances in Experimental Medicine and Biology"},"volume":"Vol.389","starting_page":"63","ending_page":"71","languages":["eng"],"identifiers":{"issn":["0065-2598"]},"misc_type":"introduction_scientific_journal"},"priority":"input_data"}
line:4, {"insert":{"user_id":"1000223301","type":"misc","id":"34550618"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=214018","label":"url"}],"paper_title":{"en":"Molecular mechanism of expression and regulation of water channel, esp. aquaporins in the exocrine gland","ja":"外分泌腺における水チャネル，特にアクアポリン5の発現と機能調節の分子機構"},"authors":{"en":[{"name":"Hosoi Kazuo"},{"name":"Kanamori Norio"},{"name":"Akamatsu Tetsuya"},{"name":"Yao Chenjuan"}],"ja":[{"name":"細井 和雄"},{"name":"金森 憲雄"},{"name":"赤松 徹也"},{"name":"姚 陳娟"}]},"publication_date":"2009-03","publication_name":{"en":", Report of research project, grant in-aid for scientific research (B)","ja":"平成18年度-平成20年度文部省科学研究費補助金(基盤研究(B))研究成果報告書"},"languages":["jpn"],"misc_type":"others"},"priority":"input_data"}
line:5, {"insert":{"user_id":"1000223301","type":"misc","id":"34550619"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=214017","label":"url"}],"paper_title":{"en":"Induction of inflammation cytokine and defense system of oral cavity: a trial in regeneration medicine","ja":"唾液腺における炎症性サイトカインの誘導と口腔の防御システム:再生医療への試み"},"authors":{"en":[{"name":"Hosoi Kazuo"},{"name":"Kanamori Norio"},{"name":"Akamatsu Tetsuya"},{"name":"Kosugi Chisato"}],"ja":[{"name":"細井 和雄"},{"name":"金森 憲雄"},{"name":"赤松 徹也"},{"name":"小杉 知里"}]},"publication_date":"2006-03","publication_name":{"en":"Report of research project, Grant-in-Aid for Exploratory Research, Tokushima, Mar. 2006","ja":"平成16年度-平成17年度文部省科学研究費補助金(萌芽研究)研究成果報告書"},"languages":["jpn"],"misc_type":"others"},"priority":"input_data"}
line:6, {"insert":{"user_id":"1000223301","type":"misc","id":"34550620"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=98291","label":"url"}],"paper_title":{"en":"Inflammation by mast cell kininogen and its suppression Development of a new drug","ja":"肥満細胞由来キニノーゲンによる炎症とその抑制 -抗アレルギー新薬の開発-"},"authors":{"en":[{"name":"Hosoi Kazuo"},{"name":"Nakajo Nobuyoshi"},{"name":"Haneji Tatsuji"},{"name":"Akamatsu Tetsuya"}],"ja":[{"name":"細井 和雄"},{"name":"中條 信義"},{"name":"羽地 達次"},{"name":"赤松 徹也"}]},"publication_date":"2004-03","publication_name":{"en":", Report of research project, grant in-aid for scientific research (B)(2)","ja":"平成13年度-平成15年度文部省科学研究費補助金(基盤研究(B)(2))研究成果報告書"},"languages":["jpn"],"misc_type":"others"},"priority":"input_data"}
line:7, {"insert":{"user_id":"1000223301","type":"misc","id":"34550621"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=98286","label":"url"}],"paper_title":{"en":": Expression and regulation of a water channel, aquaporin, in the exocrine gland","ja":"水チャネル蛋白質，アクアポリンの唾液腺細胞における発現と機能調節の分子機構"},"authors":{"en":[{"name":"Hosoi Kazuo"},{"name":"Kanamori Norio"},{"name":"Akamatsu Tetsuya"},{"name":"Tada, Jun"},{"name":"Tsumura Keiko"}],"ja":[{"name":"細井 和雄"},{"name":"金森 憲雄"},{"name":"赤松 徹也"},{"name":"多田 淳"},{"name":"津村 恵子"}]},"publication_date":"2003-03","publication_name":{"en":"Report of research project, grant in-aid for scientific research (C)(2)","ja":"平成13年度-平成14年度文部省科学研究費補助金(基盤研究(C)(2))研究成果報告書"},"languages":["jpn"],"misc_type":"others"},"priority":"input_data"}
line:8, {"insert":{"user_id":"1000223301","type":"misc","id":"34550622"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=98284","label":"url"}],"paper_title":{"en":"Molecular mechanism of expression and regulation of water channel proteins aquaporins in the salivary gland cells","ja":"水チャネル蛋白質，アクアポリンの唾液腺細胞における発現と機能調節の分子機構"},"authors":{"en":[{"name":"Hosoi Kazuo"},{"name":"Kanamori Norio"},{"name":"Matsuura, Sachiko"},{"name":"Akamatsu Tetsuya"},{"name":"Sawa, Takamasa"}],"ja":[{"name":"細井 和雄"},{"name":"金森 憲雄"},{"name":"松浦 幸子"},{"name":"赤松 徹也"},{"name":"澤 孝賢"}]},"publication_date":"2001-03","publication_name":{"en":"Report of research project, grant in-aid for scientific research (C)(2)","ja":"平成11年度-平成12年度文部省科学研究費補助金(基盤研究(C)(2))研究成果報告書"},"languages":["jpn"],"misc_type":"others"},"priority":"input_data"}
line:9, {"insert":{"user_id":"1000223301","type":"misc","id":"34550669"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=297044","label":"url"}],"paper_title":{"en":"Induced expression of subtilisin-like proprotein convertase in regeneration model of salivary gland","ja":"唾液腺再生モデルにおけるサチライシン様前駆体蛋白質変換酵素の発現誘導"},"authors":{"en":[{"name":"Makoto Minegishi"},{"name":"Akamatsu Tetsuya"},{"name":"Yao Chenjuan"},{"name":"Hasegawa Takahiro"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"嶺岸 誠"},{"name":"赤松 徹也"},{"name":"姚 陳娟"},{"name":"長谷川 敬展"},{"name":"吉村 弘"}]},"publication_date":"2014-09","publication_name":{"en":"Journal of Oral Biosciences","ja":"Journal of Oral Biosciences"},"volume":"Vol.Suppl.","starting_page":"138","ending_page":"138","languages":["jpn"],"identifiers":{"issn":["1349-0079"]}},"priority":"input_data"}
line:10, {"insert":{"user_id":"1000223301","type":"misc","id":"23667195"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/16144968","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-33644865281&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=123697","label":"url"}],"paper_title":{"en":"Downregulation of AQP2 expression in the kidney of polydipsic STR/N mice","ja":"Downregulation of AQP2 expression in the kidney of polydipsic STR/N mice"},"authors":{"en":[{"name":"Tsumura Keiko"},{"name":"Li Xuefei"},{"name":"Murdiastuti Kwartarini"},{"name":"Parvin Nahid Most"},{"name":"Akamatsu Tetsuya"},{"name":"Yao Chenjuan"},{"name":"Kanamori Norio"},{"name":"Inenaga, Kiyotoshi"},{"name":"Yamashita, Hiroshi"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"津村 恵子"},{"name":"李 雪飛"},{"name":"Murdiastuti Kwartarini"},{"name":"Parvin Nahid Most"},{"name":"赤松 徹也"},{"name":"姚 陳娟"},{"name":"金森 憲雄"},{"name":"稲永, 清敏"},{"name":"山下, 博"},{"name":"細井 和雄"}]},"description":{"en":"Aquaporin-2 (AQP2) is responsible for the concentration of urine in the kidney collecting tubule under the regulation of vasopressin. The mRNA level of this water channel in polydipsic STR/N mice was extremely reduced compared with that in normal ICR mice. In male mice, reduction of the AQP2 mRNA level was not evident at 3 wk of age, at which time water intake was not increased. At 10 wk of age, however, the AQP2 mRNA level was reduced to 10% of that in control mice, whereas water intake was increased by 36%. At 44 wk, the water intake became five times that of the control ICR mice, and the AQP2 mRNA level in these polydipsic mice was only approximately 5% of control. Similar changes were observed in the AQP2 protein level, suggesting that the mRNA level of AQP2 reflects the protein level of AQP2. These inverse changes in the AQP2 mRNA level and water intake were also evident in female mice. The data imply that polydipsia in STR/N mice may have affected AQP2 mRNA transcription in the kidney, resulting in reduced AQP2 expression, which would contribute to a reduction in overretention of water.","ja":"Aquaporin-2 (AQP2) is responsible for the concentration of urine in the kidney collecting tubule under the regulation of vasopressin. The mRNA level of this water channel in polydipsic STR/N mice was extremely reduced compared with that in normal ICR mice. In male mice, reduction of the AQP2 mRNA level was not evident at 3 wk of age, at which time water intake was not increased. At 10 wk of age, however, the AQP2 mRNA level was reduced to 10% of that in control mice, whereas water intake was increased by 36%. At 44 wk, the water intake became five times that of the control ICR mice, and the AQP2 mRNA level in these polydipsic mice was only approximately 5% of control. Similar changes were observed in the AQP2 protein level, suggesting that the mRNA level of AQP2 reflects the protein level of AQP2. These inverse changes in the AQP2 mRNA level and water intake were also evident in female mice. The data imply that polydipsia in STR/N mice may have affected AQP2 mRNA transcription in the kidney, resulting in reduced AQP2 expression, which would contribute to a reduction in overretention of water."},"publication_date":"2006-02","publication_name":{"en":"American Journal of Physiology, Renal Physiology","ja":"American Journal of Physiology, Renal Physiology"},"volume":"Vol.290","number":"No.2","starting_page":"F478","ending_page":"F485","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1152/ajprenal.00029.2005"],"issn":["1931-857X"]}},"priority":"input_data"}
line:11, {"insert":{"user_id":"1000223301","type":"misc","id":"34550668"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=297045","label":"url"}],"paper_title":{"en":"Expression of water channel AQP5 in regeneration model of salivary gland","ja":"唾液腺再生モデルにおける水チャネルAQP5の発現"},"authors":{"en":[{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Hasegawa Takahiro"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"長谷川 敬展"},{"name":"吉村 弘"}]},"publication_date":"2014-09","publication_name":{"en":"Journal of Oral Biosciences","ja":"Journal of Oral Biosciences"},"volume":"Vol.Suppl.","starting_page":"204","ending_page":"204","languages":["jpn"],"identifiers":{"issn":["1349-0079"]}},"priority":"input_data"}
line:12, {"insert":{"user_id":"1000223301","type":"misc","id":"34550667"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=297046","label":"url"}],"paper_title":{"en":"Enhanced ubiquitylation and downregulation of aquaporin-5 by ubiquitin ligases","ja":"ユビキチンリガーゼによるAQP5のユビキチン化亢進とダウンレギュレーション"},"authors":{"en":[{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"吉村 弘"}]},"publication_date":"2014-09","publication_name":{"en":"Journal of Oral Biosciences","ja":"Journal of Oral Biosciences"},"volume":"Vol.Suppl.","starting_page":"204","ending_page":"204","languages":["jpn"],"identifiers":{"issn":["1349-0079"]}},"priority":"input_data"}
line:13, {"insert":{"user_id":"1000223301","type":"misc","id":"34550666"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=297027","label":"url"}],"paper_title":{"en":"Salivary Gland Development, Differentiation, and Regeneration - Role of Subtilisin-like Proprotein Convertase PACE4/SPC4","ja":"Salivary Gland Development, Differentiation, and Regeneration - Role of Subtilisin-like Proprotein Convertase PACE4/SPC4"},"authors":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Yao Chenjuan"},{"name":"Hasegawa Takahiro"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"赤松 徹也"},{"name":"姚 陳娟"},{"name":"長谷川 敬展"},{"name":"吉村 弘"}]},"publication_date":"2014-11","publication_name":{"en":"BIT's 1st Annual World Congress of Oral & Dental Medicine Conference Abstract Book","ja":"BIT's 1st Annual World Congress of Oral & Dental Medicine Conference Abstract Book"},"starting_page":"59","ending_page":"59","languages":["eng"],"invited":true},"priority":"input_data"}
line:14, {"insert":{"user_id":"1000223301","type":"misc","id":"34550665"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=297039","label":"url"}],"paper_title":{"en":"The Defense System of Oral Cavity: Lipopolysaccharide Induced Inflammatory Response in the Mice Salivary Gland","ja":"The Defense System of Oral Cavity: Lipopolysaccharide Induced Inflammatory Response in the Mice Salivary Gland"},"authors":{"en":[{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Hasegawa Takahiro"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"長谷川 敬展"},{"name":"吉村 弘"}]},"publication_date":"2014-11","publication_name":{"en":"BIT's 1st Annual World Congress of Oral & Dental Medicine Conference Abstract Book","ja":"BIT's 1st Annual World Congress of Oral & Dental Medicine Conference Abstract Book"},"starting_page":"107","ending_page":"107","languages":["eng"],"invited":true},"priority":"input_data"}
==== end registerFile(/WWW/pub2/data/ERD/person/60376/researchmap/misc.jsonl, vwE6HI8B7kacV6CWwE6A) ====
==== begin registerFile(/WWW/pub2/data/ERD/person/60376/researchmap/books_etc.jsonl) ====
line:1, {"insert":{"user_id":"1000223301","type":"books_etc","id":"34550738"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=297023","label":"url"}],"book_title":{"en":"Methods for animal tissue culture and techniques to prevent cell death, growth defect, and cell mutation","ja":"動物細胞培養の手法と細胞死・増殖不良・細胞変異を防止する技術"},"authors":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Yao Chenjuan"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"赤松 徹也"},{"name":"姚 陳娟"},{"name":"細井 和雄"}]},"publisher":{"en":"Technical Information Institute Co., Ltd.","ja":"株式会社 技術情報協会"},"publication_date":"2014-04-30","languages":["jpn"]},"priority":"input_data"}
line:2, {"insert":{"user_id":"1000223301","type":"books_etc","id":"35817447"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383033","label":"url"}],"book_title":{"en":"Handbook of Proteolytic Enzymes. 3rd Ed. --- Proprotein Convertase PACE4.","ja":"Handbook of Proteolytic Enzymes. 3rd Ed. --- Proprotein Convertase PACE4."},"authors":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"et al."}],"ja":[{"name":"赤松 徹也"},{"name":"et al."}]},"publisher":{"en":"Academic Press","ja":"Academic Press"},"publication_date":"2012-12","languages":["eng"]},"priority":"input_data"}
line:3, {"insert":{"user_id":"1000223301","type":"books_etc","id":"34550739"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=121696","label":"url"}],"book_title":{"en":"Special Oral Biology - Salivary Glands","ja":"口腔生物学各論-唾液腺"},"authors":{"en":[{"name":"Hosoi Kazuo"},{"name":"Akamatsu Tetsuya"},{"name":".others"}],"ja":[{"name":"細井 和雄"},{"name":"赤松 徹也"},{"name":".他"}]},"publisher":{"en":"Gakken Shoin","ja":"学建書院"},"publication_date":"2006-02","languages":["jpn"]},"priority":"input_data"}
line:4, {"insert":{"user_id":"1000223301","type":"books_etc","id":"6594856"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=93558","label":"url"}],"book_title":{"en":"Experimental Manual for Molecular Cell Biology, 2nd Edition","ja":"分子細胞生物学基礎実験法 改訂第2版(分担)"},"authors":{"en":[{"name":"Hosoi Kazuo"},{"name":"Higuti Tomihiko"},{"name":"Kashimata, Masanori"},{"name":"Arakaki Rieko"},{"name":"Arakaki Naokatu"},{"name":"Tada, Jun"},{"name":"Tsumura Keiko"},{"name":"Akamatsu Tetsuya"},{"name":"Takeda, Kyouko"},{"name":"Ueno Akemichi"},{"name":"Suenaga, Midori"},{"name":"Baba Yoshinobu"},{"name":".others"}],"ja":[{"name":"細井 和雄"},{"name":"樋口 富彦"},{"name":"柏俣 正典"},{"name":"新垣 理恵子"},{"name":"新垣 尚捷"},{"name":"多田 淳"},{"name":"津村 恵子"},{"name":"赤松 徹也"},{"name":"武田 京子"},{"name":"上野 明道"},{"name":"末永 みどり"},{"name":"馬場 嘉信"},{"name":".他"}]},"publisher":{"en":"Nankodo","ja":"南江堂"},"publication_date":"2004-04-01","languages":["jpn"]},"priority":"input_data"}
line:5, {"insert":{"user_id":"1000223301","type":"books_etc","id":"34550740"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=72166","label":"url"}],"book_title":{"en":"Cyclic AMP-inducible procalcitonin processing in thyroidal parafollicular cells is regulated by the Kexin family protease, PC1.","ja":"Cyclic AMP-inducible procalcitonin processing in thyroidal parafollicular cells is regulated by the Kexin family protease, PC1."},"authors":{"en":[{"name":"Nagamune Hideaki"},{"name":"Muramatsu Kazuaki"},{"name":"Higashine Masakatsu"},{"name":"Akamatsu Tetsuya"},{"name":"Tamai Yasuhiro"},{"name":"Yonetomi Yasuo"},{"name":"Tsuji Akihiko"},{"name":"Izumi Keisuke"},{"name":"Sakaguchi Takemasa"},{"name":"Yoshida Tetsuya"},{"name":"Matsuda Yoshiko"}],"ja":[{"name":"長宗 秀明"},{"name":"Muramatsu Kazuaki"},{"name":"Higashine Masakatsu"},{"name":"赤松 徹也"},{"name":"Tamai Yasuhiro"},{"name":"Yonetomi Yasuo"},{"name":"辻 明彦"},{"name":"泉 啓介"},{"name":"Sakaguchi Takemasa"},{"name":"Yoshida Tetsuya"},{"name":"松田 佳子"}]},"publisher":{"en":"IOS Press","ja":"IOS Press"},"publication_date":"1997-03","languages":["eng"],"description":{"en":"カルシウム調節ホルモンであるカルシトニンは甲状腺傍濾胞細胞より分泌されるが, 不活性な前駆体として合成された後, プロセシングを受けて初めて活性化される. 本研究ではcAMP刺激により著増するカルシトニンのプロセシングがKexin family proteaseに属する酵素PC1により調節されることを初めて明らかにした.","ja":"カルシウム調節ホルモンであるカルシトニンは甲状腺傍濾胞細胞より分泌されるが, 不活性な前駆体として合成された後, プロセシングを受けて初めて活性化される. 本研究ではcAMP刺激により著増するカルシトニンのプロセシングがKexin family proteaseに属する酵素PC1により調節されることを初めて明らかにした."}},"priority":"input_data"}
==== end registerFile(/WWW/pub2/data/ERD/person/60376/researchmap/books_etc.jsonl, xgE6HI8B7kacV6CWwU5A) ====
==== begin registerFile(/WWW/pub2/data/ERD/person/60376/researchmap/awards.jsonl) ====
line:1, {"insert":{"user_id":"1000223301","type":"awards","id":"34550754"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=91890","label":"url"}],"award_name":{"en":"康楽賞","ja":"康楽賞"},"winners":{"en":[{"name":"Akamatsu Tetsuya"}],"ja":[{"name":"赤松 徹也"}]},"association":{"en":"The Koraku Foundation","ja":"財団法人 三木康楽会"},"award_date":"1994-01-21"},"priority":"input_data"}
line:2, {"insert":{"user_id":"1000223301","type":"awards","id":"34550755"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=91898","label":"url"}],"award_name":{"en":"高田充歯科基礎医学奨励賞","ja":"高田充歯科基礎医学奨励賞"},"winners":{"en":[{"name":"Akamatsu Tetsuya"}],"ja":[{"name":"赤松 徹也"}]},"association":{"en":"Course in Dentistry","ja":"歯学科"},"award_date":"2003-12-15"},"priority":"input_data"}
line:3, {"insert":{"user_id":"1000223301","type":"awards","id":"34550756"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=225999","label":"url"}],"award_name":{"en":"第21回 歯科基礎医学会賞","ja":"第21回 歯科基礎医学会賞"},"winners":{"en":[{"name":"Akamatsu Tetsuya"}],"ja":[{"name":"赤松 徹也"}]},"award_title":{"en":"Inhibition and transcriptional silencing of a subtilisin-like proprotein convertase, PACE4/SPC4, reduces the branching morphogenesis of and AQP5 expression in rat embryonic submandibular gland","ja":"Inhibition and transcriptional silencing of a subtilisin-like proprotein convertase, PACE4/SPC4, reduces the branching morphogenesis of and AQP5 expression in rat embryonic submandibular gland"},"association":{"en":"Japanese Association for Oral Biology","ja":"歯科基礎医学会"},"award_date":"2009-09-10"},"priority":"input_data"}
line:4, {"insert":{"user_id":"1000223301","type":"awards","id":"34550757"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=226005","label":"url"}],"award_name":{"en":"徳島大学歯学部若手研究奨励賞","ja":"徳島大学歯学部若手研究奨励賞"},"winners":{"en":[{"name":"Akamatsu Tetsuya"}],"ja":[{"name":"赤松 徹也"}]},"award_title":{"en":"唾液腺発生におけるサチライシン様前駆体蛋白質変換酵素PACE4の生理機能解明","ja":"唾液腺発生におけるサチライシン様前駆体蛋白質変換酵素PACE4の生理機能解明"},"association":{"en":"Course in Dentistry","ja":"歯学科"},"award_date":"2010-07-29"},"priority":"input_data"}
line:5, {"insert":{"user_id":"1000223301","type":"awards","id":"34550758"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=249249","label":"url"}],"award_name":{"en":"徳島大学歯学部ベストメンター賞","ja":"徳島大学歯学部ベストメンター賞"},"winners":{"en":[{"name":"Akamatsu Tetsuya"}],"ja":[{"name":"赤松 徹也"}]},"association":{"en":"Faculty of Dentistry","ja":"歯学部"},"award_date":"2012-03-22"},"priority":"input_data"}
line:6, {"insert":{"user_id":"1000223301","type":"awards","id":"34550759"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=266906","label":"url"}],"award_name":{"en":"歯学部優秀教育賞","ja":"歯学部優秀教育賞"},"winners":{"en":[{"name":"Akamatsu Tetsuya"}],"ja":[{"name":"赤松 徹也"}]},"association":{"en":"Faculty of Dentistry","ja":"歯学部"},"award_date":"2012-07-26"},"priority":"input_data"}
line:7, {"insert":{"user_id":"1000223301","type":"awards","id":"34550760"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=318185","label":"url"}],"award_name":{"en":"H27年度ベストメンター賞","ja":"H27年度ベストメンター賞"},"winners":{"en":[{"name":"Akamatsu Tetsuya"}],"ja":[{"name":"赤松 徹也"}]},"association":{"en":"Faculty of Dentistry","ja":"歯学部"},"award_date":"2016-03-24"},"priority":"input_data"}
==== end registerFile(/WWW/pub2/data/ERD/person/60376/researchmap/awards.jsonl, ywE6HI8B7kacV6CWwk4U) ====
==== begin registerFile(/WWW/pub2/data/ERD/person/60376/researchmap/presentations.jsonl) ====
line:1, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550672"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=329968","label":"url"}],"presentation_title":{"en":"Induced expression of a subtilisin-like proprotein convertase PACE4 in the regeneration model of rat submandibular gland.","ja":"Induced expression of a subtilisin-like proprotein convertase PACE4 in the regeneration model of rat submandibular gland."},"presenters":{"en":[{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Hasegawa Takahiro"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"長谷川 敬展"},{"name":"吉村 弘"}]},"event":{"en":"The 4th International Symposium on Salivary Glands in Honor of Niels Stensen","ja":"The 4th International Symposium on Salivary Glands in Honor of Niels Stensen"},"publication_date":"2016-11-30","languages":["eng"],"location":{"en":"Okazaki (Japan)","ja":"Okazaki (Japan)"},"is_international_presentation":true},"priority":"input_data"}
line:2, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550673"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=329962","label":"url"}],"presentation_title":{"en":"Sexual difference in the regeneration model of the rat submandibular gland.","ja":"Sexual difference in the regeneration model of the rat submandibular gland."},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Yao Chenjuan"},{"name":"Hasegawa Takahiro"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"赤松 徹也"},{"name":"姚 陳娟"},{"name":"長谷川 敬展"},{"name":"吉村 弘"}]},"event":{"en":"The 4th International Symposium on Salivary Glands in Honor of Niels Stensen","ja":"The 4th International Symposium on Salivary Glands in Honor of Niels Stensen"},"publication_date":"2016-11-30","languages":["eng"],"location":{"en":"Okazaki (Japan)","ja":"Okazaki (Japan)"},"is_international_presentation":true},"priority":"input_data"}
line:3, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550674"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=330499","label":"url"}],"presentation_title":{"en":"Post-translational modifications of water channel aquaporin-5 in salivary gland cells, Oral Neuroscience 2016","ja":"Post-translational modifications of water channel aquaporin-5 in salivary gland cells, Oral Neuroscience 2016"},"presenters":{"en":[{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"吉村 弘"}]},"event":{"en":"Oral Neuroscience 2016","ja":"Oral Neuroscience 2016"},"publication_date":"2016-10-01","languages":["eng"],"location":{"en":"Osaka","ja":"Osaka"},"is_international_presentation":true},"priority":"input_data"}
line:4, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550675"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=332303","label":"url"}],"presentation_title":{"en":"Synaptic plasticity in the brain -Roles of NMDA receptor- (Invited lecture at Nantong University)","ja":"Synaptic plasticity in the brain -Roles of NMDA receptor- (Invited lecture at Nantong University)"},"presenters":{"en":[{"name":"Yoshimura Hiroshi"},{"name":"Akamatsu Tetsuya"},{"name":"Yao Chenjuan"},{"name":"Hasegawa Takahiro"}],"ja":[{"name":"吉村 弘"},{"name":"赤松 徹也"},{"name":"姚 陳娟"},{"name":"長谷川 敬展"}]},"publication_date":"2016-09-22","invited":true,"languages":["eng"],"is_international_presentation":true},"priority":"input_data"}
line:5, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550676"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=297040","label":"url"}],"presentation_title":{"en":"The Defense System of Oral Cavity: Lipopolysaccharide Induced Inflammatory Response in the Mice Salivary Gland","ja":"The Defense System of Oral Cavity: Lipopolysaccharide Induced Inflammatory Response in the Mice Salivary Gland"},"presenters":{"en":[{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Hasegawa Takahiro"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"長谷川 敬展"},{"name":"吉村 弘"}]},"event":{"en":"BIT's 1st Annual International Congress of Oral & Dental Medicine, Session 9: Oral Immunological Diseases, Allergy and Inflammation","ja":"BIT's 1st Annual International Congress of Oral & Dental Medicine, Session 9: Oral Immunological Diseases, Allergy and Inflammation"},"publication_date":"2014-11-15","invited":true,"languages":["eng"],"location":{"en":"Haikou, China","ja":"Haikou, China"},"is_international_presentation":true},"priority":"input_data"}
line:6, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550677"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=297025","label":"url"}],"presentation_title":{"en":"Salivary Gland Development, Differentiation, and Regeneration - Role of Subtilisin-like Proprotein Convertase PACE4/SPC4","ja":"Salivary Gland Development, Differentiation, and Regeneration - Role of Subtilisin-like Proprotein Convertase PACE4/SPC4"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Yao Chenjuan"},{"name":"Hasegawa Takahiro"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"赤松 徹也"},{"name":"姚 陳娟"},{"name":"長谷川 敬展"},{"name":"吉村 弘"}]},"event":{"en":"BIT's 1st Annual International Congress of Oral & Dental Medicine, Session 3: Oral Biology","ja":"BIT's 1st Annual International Congress of Oral & Dental Medicine, Session 3: Oral Biology"},"publication_date":"2014-11-14","invited":true,"languages":["eng"],"location":{"en":"Haikou, China","ja":"Haikou, China"},"is_international_presentation":true},"priority":"input_data"}
line:7, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550678"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/111488","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/20224238","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=214000","label":"url"}],"presentation_title":{"en":"Effects of natural point mutation of rat aquaporin 5 expressed in vitro on its capacity of water permeability and membrane trafficking","ja":"Effects of natural point mutation of rat aquaporin 5 expressed in vitro on its capacity of water permeability and membrane trafficking"},"presenters":{"en":[{"name":"Karabasil, Ratko, Mileva"},{"name":"Murdiastuti, Kwartarini"},{"name":"Purwanti, Nunuk"},{"name":"Ahmad, Azlina"},{"name":"Purevjav Javkhlan"},{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Karabasil, Ratkom, Mileva"},{"name":"Murdiastuti, Kwartarini"},{"name":"Purwanti, Nunuk"},{"name":"Ahmad, Azlina"},{"name":"フルジャフ ジャフラン"},{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"細井 和雄"}]},"event":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"publication_date":"2009-12","languages":["eng"],"location":{"en":"Tokushima","ja":"Tokushima"},"description":{"en":"In the colony of Sprague-Dawley (SD) strain, we found that there were rats expressing a mutant AQP5, which has a point mutation at nt 308 (G308A), leading to a replacement of (103)Gly with (103)Asp in the 3rd transmembrane domain. The mutant molecule scarcely expressed in the acinar cells, probably because of ineffective trafficking. The mutant molecule, however, showed normal water permeability when assessed by the oocyte system.","ja":"In the colony of Sprague-Dawley (SD) strain, we found that there were rats expressing a mutant AQP5, which has a point mutation at nt 308 (G308A), leading to a replacement of (103)Gly with (103)Asp in the 3rd transmembrane domain. The mutant molecule scarcely expressed in the acinar cells, probably because of ineffective trafficking. The mutant molecule, however, showed normal water permeability when assessed by the oocyte system."},"is_international_presentation":true},"priority":"input_data"}
line:8, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550679"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/111354","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/20224205","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=213999","label":"url"}],"presentation_title":{"en":"Induction of calprotectin mRNAs by lipopolysaccharide in the salivary gland of mice","ja":"Induction of calprotectin mRNAs by lipopolysaccharide in the salivary gland of mice"},"presenters":{"en":[{"name":"Javkhlan, Purevjav"},{"name":"Hiroshima Yuka"},{"name":"Ahmad, Azlina"},{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Kido Jun-ichi"},{"name":"Nagata Toshihiko"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Javkhlan, Purevjav"},{"name":"廣島 佑香"},{"name":"Ahmad, Azlina"},{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"木戸 淳一"},{"name":"永田 俊彦"},{"name":"細井 和雄"}]},"event":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"publication_date":"2009-12","languages":["eng"],"location":{"en":"Tokushima","ja":"Tokushima"},"description":{"en":"Calprotectin is a major cytosolic calcium-binding protein of leukocytes which belongs to the S100 protein family. S100A8 and S100A9, major types of calprotectin are heterodimeric complexes being composed of light- and heavy-chain subunits. The calprotectin levels in the plasma, feces, synovial fluid, gingival crevicular fluid, dental calculus and saliva change when the host animal suffers from several inflammatory diseases. Members of Toll-like receptor (TLR) family are pattern-recognition receptors for lipopolysaccharide (LPS) and other pathogens. Here we examined if the biological role of TLR receptor is reflected to the calprotectin expression in the salivary gland. Time course study by using real-time RT-PCR detected higher levels of S100A8 and S100A9 mRNA at 1.5-3 h after injection of LPS in both the submandibular gland (SMG) and parotid gland (PG) of C3H/HeN mice but not in the same tissues of C3H/HeJ, a TLR-4 mutant strain, indicating that this induction is mediated via the TLR-4. These results indicate that, an inflammatory marker, calprotectin, is expressed in the mouse salivary gland and that LPS stimulated its synthesis. Calprotectin (S100A8/A9) showed minimum expression in all cellular segments in the SMG except excretory duct cells, which showed strong signal at the cytoplasm. LPS induced their expressions in the granular convoluted tubular cells and striated duct cells. In the PG, these proteins were expressed very weakly in both duct and acinar cells with a little stronger staining for the former cells. LPS injection induced calprotectin (S100A8/A9) in both duct and acinar cells especially in the former cells.","ja":"Calprotectin is a major cytosolic calcium-binding protein of leukocytes which belongs to the S100 protein family. S100A8 and S100A9, major types of calprotectin are heterodimeric complexes being composed of light- and heavy-chain subunits. The calprotectin levels in the plasma, feces, synovial fluid, gingival crevicular fluid, dental calculus and saliva change when the host animal suffers from several inflammatory diseases. Members of Toll-like receptor (TLR) family are pattern-recognition receptors for lipopolysaccharide (LPS) and other pathogens. Here we examined if the biological role of TLR receptor is reflected to the calprotectin expression in the salivary gland. Time course study by using real-time RT-PCR detected higher levels of S100A8 and S100A9 mRNA at 1.5-3 h after injection of LPS in both the submandibular gland (SMG) and parotid gland (PG) of C3H/HeN mice but not in the same tissues of C3H/HeJ, a TLR-4 mutant strain, indicating that this induction is mediated via the TLR-4. These results indicate that, an inflammatory marker, calprotectin, is expressed in the mouse salivary gland and that LPS stimulated its synthesis. Calprotectin (S100A8/A9) showed minimum expression in all cellular segments in the SMG except excretory duct cells, which showed strong signal at the cytoplasm. LPS induced their expressions in the granular convoluted tubular cells and striated duct cells. In the PG, these proteins were expressed very weakly in both duct and acinar cells with a little stronger staining for the former cells. LPS injection induced calprotectin (S100A8/A9) in both duct and acinar cells especially in the former cells."},"is_international_presentation":true},"priority":"input_data"}
line:9, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550680"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/111348","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/20224200","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=213998","label":"url"}],"presentation_title":{"en":"Down-regulation of submandibular gland AQP5 following parasympathetic denervation in rats","ja":"Down-regulation of submandibular gland AQP5 following parasympathetic denervation in rats"},"presenters":{"en":[{"name":"Ahmad, Azlina"},{"name":"Li Xuefei"},{"name":"Javkhlan, Purevjav"},{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Ahmad, Azlina"},{"name":"李 雪飛"},{"name":"Javkhlan, Purevjav"},{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"細井 和雄"}]},"event":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"publication_date":"2009-12","languages":["eng"],"location":{"en":"Tokushima","ja":"Tokushima"},"description":{"en":"Following chorda tympani denervation (CTD, parasympathetomy), the protein levels of aquaporin5 (AQP5) as well as AQP1 and Na(+)K(+)ATPase alpha-subunit in the rat submandibular gland (SMG) were found to be decreased significantly. However, the level of another membrane protein, dipeptidyl peptidase IV was not affected by CTD, suggesting a selective reduction of AQP5, AQP1, and Na(+)K(+)ATPase alpha -subunit proteins by CTD. However, the AQP5 mRNA level was scarcely affected by CTD, which suggested that transcription process of AQP5 was unaffected by this operation. AQP5 protein was shown to be degraded in vitro by the extract of the SMG obtained from normal rat; inhibitor experiments in vitro suggested cathepsin B was a responsible enzyme. Co-localization of AQP5 and LAMP-2, a lysosomal marker, implicated AQP5 is degraded in lysosomes. A significant increase in the protein levels of LC3-II, an autophagy marker, at day 1 after CTD, and co-localization of the LC3 protein and AQP5, suggested that CTD activated autophagy of SMG, leading to AQP5 degradation.","ja":"Following chorda tympani denervation (CTD, parasympathetomy), the protein levels of aquaporin5 (AQP5) as well as AQP1 and Na(+)K(+)ATPase alpha-subunit in the rat submandibular gland (SMG) were found to be decreased significantly. However, the level of another membrane protein, dipeptidyl peptidase IV was not affected by CTD, suggesting a selective reduction of AQP5, AQP1, and Na(+)K(+)ATPase alpha -subunit proteins by CTD. However, the AQP5 mRNA level was scarcely affected by CTD, which suggested that transcription process of AQP5 was unaffected by this operation. AQP5 protein was shown to be degraded in vitro by the extract of the SMG obtained from normal rat; inhibitor experiments in vitro suggested cathepsin B was a responsible enzyme. Co-localization of AQP5 and LAMP-2, a lysosomal marker, implicated AQP5 is degraded in lysosomes. A significant increase in the protein levels of LC3-II, an autophagy marker, at day 1 after CTD, and co-localization of the LC3 protein and AQP5, suggested that CTD activated autophagy of SMG, leading to AQP5 degradation."},"is_international_presentation":true},"priority":"input_data"}
line:10, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550681"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/111340","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/20224192","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=213997","label":"url"}],"presentation_title":{"en":"Involvement of the IL-6/STAT3/Sca-1 system in proliferation of duct cells following duct ligation in the submandibular gland of mice","ja":"Involvement of the IL-6/STAT3/Sca-1 system in proliferation of duct cells following duct ligation in the submandibular gland of mice"},"presenters":{"en":[{"name":"Purwanti, Nunuk"},{"name":"Ahmad, Azlina"},{"name":"Karabasil, Ratko, Mileva"},{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Purwanti, Nunuk"},{"name":"Ahmad, Azlina"},{"name":"Karabasil, Ratko, Mileva"},{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"細井 和雄"}]},"event":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"publication_date":"2009-12","languages":["eng"],"location":{"en":"Tokushima","ja":"Tokushima"},"description":{"en":"Ligation of the main excretory duct (MED) of the mouse submandibular gland (SMG) induced the expression of Sca-1, a stem cell marker. Sca-1 expression increased prominently in almost all of cells in the duct system, except the acinar cells. Sca-1 induction was accompanied with phosphorylated-STAT3 (Y705) elevation, which was localized in the nuclei of all duct cells. Electrophoretic mobility shift assay (EMSA) confirmed the specific binding of STAT3 to the GAS sequence, a biding site of gamma interferon activating site. Present study suggested one of the initial steps of the tissue regeneration after injury includes STAT3 pathway.","ja":"Ligation of the main excretory duct (MED) of the mouse submandibular gland (SMG) induced the expression of Sca-1, a stem cell marker. Sca-1 expression increased prominently in almost all of cells in the duct system, except the acinar cells. Sca-1 induction was accompanied with phosphorylated-STAT3 (Y705) elevation, which was localized in the nuclei of all duct cells. Electrophoretic mobility shift assay (EMSA) confirmed the specific binding of STAT3 to the GAS sequence, a biding site of gamma interferon activating site. Present study suggested one of the initial steps of the tissue regeneration after injury includes STAT3 pathway."},"is_international_presentation":true},"priority":"input_data"}
line:11, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550682"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/111337","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/20224189","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=213995","label":"url"}],"presentation_title":{"en":"Salivary Gland Development: Its mediation by a subtilisin-like proprotein convertase, PACE4","ja":"Salivary Gland Development: Its mediation by a subtilisin-like proprotein convertase, PACE4"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Ahmad, Azlina"},{"name":"Javkhlan, Purevjav"},{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"赤松 徹也"},{"name":"Ahmad, Azlina"},{"name":"Javkhlan, Purevjav"},{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"細井 和雄"}]},"event":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"publication_date":"2009-12","languages":["eng"],"location":{"en":"Tokushima","ja":"Tokushima"},"description":{"en":"The submandibular gland (SMG) develops under the epithelial-mesenchymal interaction. Its process is regulated by various growth/differentiation factors, which are synthesized as inactive precursors and activated via the limited proteolysis at their multi basic amino acid site(s) such as Arg-X-Lys/Arg-Arg. Although many of these processing steps are elucidated to be catalyzed by subtilisin-like proprotein convertases (SPCs), little is known about the role of SPCs in the SMG development. Here, we focused upon the physiological role of PACE4 (SPC4), a member of SPC family, in the SMG development. In the organ culture system of rat embryonic SMG (E15), Dec-RVKR-CMK, a potent inhibitor for SPCs, inhibited the salivary branching and the expression of an exocrine gland type water channel, AQP5. However, other peptidyl-CMKs and inhibitors for trypsin-like serine proteases including leupeptin did not affect the salivary branching and AQP5 expression. Dec-RVKR-CMK also suppressed the expression of PACE4, but not furin, another member of the family. The specific antibody for the catalytic domain of PACE4 suppressed the salivary branching and AQP5 expression similarly. These inhibitory effects of Dec-RVKR-CMK were partially rescued by the addition of recombinant BMP2 whose precursor is a candidate for the physiological substrates of PACE4. Further, the transcriptional silencing of PACE4 by its specific siRNAs caused the suppression of both the salivary branching and AQP5 expression in the present organ culture system. These observations strongly support the idea that PACE4 mediates the SMG development.","ja":"The submandibular gland (SMG) develops under the epithelial-mesenchymal interaction. Its process is regulated by various growth/differentiation factors, which are synthesized as inactive precursors and activated via the limited proteolysis at their multi basic amino acid site(s) such as Arg-X-Lys/Arg-Arg. Although many of these processing steps are elucidated to be catalyzed by subtilisin-like proprotein convertases (SPCs), little is known about the role of SPCs in the SMG development. Here, we focused upon the physiological role of PACE4 (SPC4), a member of SPC family, in the SMG development. In the organ culture system of rat embryonic SMG (E15), Dec-RVKR-CMK, a potent inhibitor for SPCs, inhibited the salivary branching and the expression of an exocrine gland type water channel, AQP5. However, other peptidyl-CMKs and inhibitors for trypsin-like serine proteases including leupeptin did not affect the salivary branching and AQP5 expression. Dec-RVKR-CMK also suppressed the expression of PACE4, but not furin, another member of the family. The specific antibody for the catalytic domain of PACE4 suppressed the salivary branching and AQP5 expression similarly. These inhibitory effects of Dec-RVKR-CMK were partially rescued by the addition of recombinant BMP2 whose precursor is a candidate for the physiological substrates of PACE4. Further, the transcriptional silencing of PACE4 by its specific siRNAs caused the suppression of both the salivary branching and AQP5 expression in the present organ culture system. These observations strongly support the idea that PACE4 mediates the SMG development."},"is_international_presentation":true},"priority":"input_data"}
line:12, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817448"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383116","label":"url"}],"presentation_title":{"en":"Potential down-regulation of parotid gland AQP5 by LPS via cross-coupling of NF-κB/AP1","ja":"Potential down-regulation of parotid gland AQP5 by LPS via cross-coupling of NF-κB/AP1"},"presenters":{"en":[{"name":"Yao Chenjuan"},{"name":"Azlina Ahmad"},{"name":"Purevjav Javkhlan"},{"name":"Hasegawa Takahiro"},{"name":"Akamatsu Tetsuya"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"姚 陳娟"},{"name":"Azlina Ahmad"},{"name":"フルジャフ ジャフラン"},{"name":"長谷川 敬展"},{"name":"赤松 徹也"},{"name":"細井 和雄"}]},"event":{"en":"The 11th International Symposium on Exocrine Secretion, Tokushima 09 ''Exocrine Secretion Mechanism and Disease''","ja":"The 11th International Symposium on Exocrine Secretion, Tokushima 09 ''Exocrine Secretion Mechanism and Disease''"},"publication_date":"2009-07","languages":["eng"],"location":{"en":"Tokushima","ja":"Tokushima"},"is_international_presentation":true},"priority":"input_data"}
line:13, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817449"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383111","label":"url"}],"presentation_title":{"en":"Is AQP5 down-regulated via autophagic pathway following chorda tympani denervation?","ja":"Is AQP5 down-regulated via autophagic pathway following chorda tympani denervation?"},"presenters":{"en":[{"name":"Azlina Ahmad"},{"name":"Purwanti Nunuk"},{"name":"Karabasil R. Mileva"},{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Azlina Ahmad"},{"name":"Purwanti Nunuk"},{"name":"Karabasil R. Mileva"},{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"細井 和雄"}]},"event":{"en":"The International Symposium on Oral Sciences to Improve the Quality of Life, organized by Toshihiko Nagata","ja":"The International Symposium on Oral Sciences to Improve the Quality of Life, organized by Toshihiko Nagata"},"publication_date":"2008-09","languages":["eng"],"location":{"en":"Tokushima","ja":"Tokushima"},"is_international_presentation":true},"priority":"input_data"}
line:14, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817450"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383110","label":"url"}],"presentation_title":{"en":"Analyses of rat AQP5 G103D mutant expressed in MDCK-II cells and Xenopus oocytes","ja":"Analyses of rat AQP5 G103D mutant expressed in MDCK-II cells and Xenopus oocytes"},"presenters":{"en":[{"name":"Karabasil R. Mileva"},{"name":"Hasegawa Takahiro"},{"name":"Azlina Ahmad"},{"name":"Purwanti Nunuk"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Tomioka Shigemasa"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Karabasil R. Mileva"},{"name":"長谷川 敬展"},{"name":"Azlina Ahmad"},{"name":"Purwanti Nunuk"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"Tomioka Shigemasa"},{"name":"細井 和雄"}]},"event":{"en":"The International Symposium on Oral Sciences to Improve the Quality of Life, organized by Toshihiko Nagata","ja":"The International Symposium on Oral Sciences to Improve the Quality of Life, organized by Toshihiko Nagata"},"publication_date":"2008-09","languages":["eng"],"location":{"en":"Tokushima","ja":"Tokushima"},"is_international_presentation":true},"priority":"input_data"}
line:15, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817451"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383109","label":"url"}],"presentation_title":{"en":"Activation of IL-6/STAT3/Sca-1 system induces proliferation of duct cells in the duct-ligated mouse submandibular gland","ja":"Activation of IL-6/STAT3/Sca-1 system induces proliferation of duct cells in the duct-ligated mouse submandibular gland"},"presenters":{"en":[{"name":"Puwanti Nunuk"},{"name":"Tsuji Daisuke"},{"name":"Karabasil Ratko Mileva"},{"name":"Yao Chenjuan"},{"name":"Hasegawa Takahiro"},{"name":"Akamatsu Tetsuya"},{"name":"Itou Kouji"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Puwanti Nunuk"},{"name":"辻 大輔"},{"name":"Karabasil Ratko Mileva"},{"name":"姚 陳娟"},{"name":"長谷川 敬展"},{"name":"赤松 徹也"},{"name":"伊藤 孝司"},{"name":"細井 和雄"}]},"event":{"en":"The 2nd International Symposium on The Future Direction of Oral Sciences in The 21st Century-Oral Sciences for Our Healthy Life-, organized by Toshihiko Nagata","ja":"The 2nd International Symposium on The Future Direction of Oral Sciences in The 21st Century-Oral Sciences for Our Healthy Life-, organized by Toshihiko Nagata"},"publication_date":"2007-12","languages":["eng"],"location":{"en":"Tokushima","ja":"Tokushima"},"is_international_presentation":true},"priority":"input_data"}
line:16, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817452"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383102","label":"url"}],"presentation_title":{"en":"A naturally occurring point mutation in rat AQP5 influencing its membrane trafficking in and water secretion from salivary gland","ja":"A naturally occurring point mutation in rat AQP5 influencing its membrane trafficking in and water secretion from salivary gland"},"presenters":{"en":[{"name":"Karabasil R. Mileva"},{"name":"Murdiastuti Kwartarini"},{"name":"Hasegawa Takahiro"},{"name":"Purwanti Nunuk"},{"name":"Azlina Ahmad"},{"name":"Li Xuefei"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Karabasil R. Mileva"},{"name":"Murdiastuti Kwartarini"},{"name":"長谷川 敬展"},{"name":"Purwanti Nunuk"},{"name":"Azlina Ahmad"},{"name":"李 雪飛"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"The 5th International Conference of Aquaporin","ja":"The 5th International Conference of Aquaporin"},"publication_date":"2007-07","languages":["eng"],"location":{"en":"Nara","ja":"Nara"},"is_international_presentation":true},"priority":"input_data"}
line:17, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817453"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383101","label":"url"}],"presentation_title":{"en":"Effects of autonomic denervation and administration of M3 muscarinic receptor agonist on the AQP5 expression in the rat submandibular gland","ja":"Effects of autonomic denervation and administration of M3 muscarinic receptor agonist on the AQP5 expression in the rat submandibular gland"},"presenters":{"en":[{"name":"Li Xuefei"},{"name":"Azlina Ahmad"},{"name":"Karabasil R. Mileva"},{"name":"Purwanti Nunuk"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"李 雪飛"},{"name":"Azlina Ahmad"},{"name":"Karabasil R. Mileva"},{"name":"Purwanti Nunuk"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"The 5th International Conference of Aquaporin","ja":"The 5th International Conference of Aquaporin"},"publication_date":"2007-07","languages":["eng"],"location":{"en":"Nara","ja":"Nara"},"is_international_presentation":true},"priority":"input_data"}
line:18, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817454"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383100","label":"url"}],"presentation_title":{"en":"LPS induces down-regulation of AQP5 and AQP1 via Nf-kB and MAPK pathways in the mouse parotid gland","ja":"LPS induces down-regulation of AQP5 and AQP1 via Nf-kB and MAPK pathways in the mouse parotid gland"},"presenters":{"en":[{"name":"Yao Chenjuan"},{"name":"Karabasil R. Mileva"},{"name":"Purwanti Nunuk"},{"name":"Azlina Ahmad"},{"name":"Li Xuefei"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"姚 陳娟"},{"name":"Karabasil R. Mileva"},{"name":"Purwanti Nunuk"},{"name":"Azlina Ahmad"},{"name":"李 雪飛"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"The 5th International Conference of Aquaporin","ja":"The 5th International Conference of Aquaporin"},"publication_date":"2007-07","languages":["eng"],"location":{"en":"Nara","ja":"Nara"},"is_international_presentation":true},"priority":"input_data"}
line:19, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817455"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383099","label":"url"}],"presentation_title":{"en":"Prenatal expression of rat salivary AQP5 is dependent on the submandibular gland development mediated by a subtilisin-like proprotein convertase PACE4","ja":"Prenatal expression of rat salivary AQP5 is dependent on the submandibular gland development mediated by a subtilisin-like proprotein convertase PACE4"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Purwanti Nunuk"},{"name":"Azlina Ahmad"},{"name":"Karabasil R. Mileva"},{"name":"Li Xuefei"},{"name":"Yao Chenjuan"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"赤松 徹也"},{"name":"Purwanti Nunuk"},{"name":"Azlina Ahmad"},{"name":"Karabasil R. Mileva"},{"name":"李 雪飛"},{"name":"姚 陳娟"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"The 5th International Conference of Aquaporin","ja":"The 5th International Conference of Aquaporin"},"publication_date":"2007-07","languages":["eng"],"location":{"en":"Nara","ja":"Nara"},"is_international_presentation":true},"priority":"input_data"}
line:20, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817456"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=161680","label":"url"}],"presentation_title":{"en":"Alterations of AQP5, cellular markers of duct, and Sca-1 expression in the duct-ligated mouse submandibular gland","ja":"Alterations of AQP5, cellular markers of duct, and Sca-1 expression in the duct-ligated mouse submandibular gland"},"presenters":{"en":[{"name":"Puwanti Nunuk"},{"name":"Tsuji Daisuke"},{"name":"Azlina Ahmad"},{"name":"Karabasil Ratko Mileva"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Itou Kouji"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Puwanti Nunuk"},{"name":"辻 大輔"},{"name":"Azlina Ahmad"},{"name":"Karabasil Ratko Mileva"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"伊藤 孝司"},{"name":"細井 和雄"}]},"event":{"en":"The 5th International Conference of Aquaporin","ja":"The 5th International Conference of Aquaporin"},"publication_date":"2007-07","languages":["eng"],"location":{"en":"Nara","ja":"Nara"},"is_international_presentation":true},"priority":"input_data"}
line:21, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817457"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383098","label":"url"}],"presentation_title":{"en":"Point mutation of AQP5 in Sprague-Dawley rats and its implication for salivary gland physiology","ja":"Point mutation of AQP5 in Sprague-Dawley rats and its implication for salivary gland physiology"},"presenters":{"en":[{"name":"Karabasil R. Mileva"},{"name":"Hasegawa Takahiro"},{"name":"Purwanti Nunuk"},{"name":"Murdiastuti Kwartarini"},{"name":"Li Xuefei"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Karabasil R. Mileva"},{"name":"長谷川 敬展"},{"name":"Purwanti Nunuk"},{"name":"Murdiastuti Kwartarini"},{"name":"李 雪飛"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"The 1st International Symposium and Workshop on The Future Direction of Oral Sciences in The 21st Century, organized by Bando, E.","ja":"The 1st International Symposium and Workshop on The Future Direction of Oral Sciences in The 21st Century, organized by Bando, E."},"publication_date":"2007-03","languages":["eng"],"location":{"en":"Awaji","ja":"Awaji"},"is_international_presentation":true},"priority":"input_data"}
line:22, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817458"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383097","label":"url"}],"presentation_title":{"en":"Effects of autonomic denervation and administration of muscarinic receptor agonist on the expression of AQPs in the rat submandibular gland","ja":"Effects of autonomic denervation and administration of muscarinic receptor agonist on the expression of AQPs in the rat submandibular gland"},"presenters":{"en":[{"name":"Li Xuefei"},{"name":"Karabasil R. Mileva"},{"name":"Purwanti Nunuk"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"李 雪飛"},{"name":"Karabasil R. Mileva"},{"name":"Purwanti Nunuk"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"The 1st International Symposium and Workshop on The Future Direction of Oral Sciences in The 21st Century, organized by Bando, E.","ja":"The 1st International Symposium and Workshop on The Future Direction of Oral Sciences in The 21st Century, organized by Bando, E."},"publication_date":"2007-03","languages":["eng"],"location":{"en":"Awaji","ja":"Awaji"},"is_international_presentation":true},"priority":"input_data"}
line:23, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817459"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=161685","label":"url"}],"presentation_title":{"en":"Changes of cellular markers of duct/acinni and side populations in the duct-ligated mouse submandibular gland","ja":"Changes of cellular markers of duct/acinni and side populations in the duct-ligated mouse submandibular gland"},"presenters":{"en":[{"name":"Purwanti Nunuk"},{"name":"Tsuji Daisuke"},{"name":"Karabasil Ratko Mileva"},{"name":"Li Xuefei"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Itou Kouji"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Purwanti Nunuk"},{"name":"辻 大輔"},{"name":"Karabasil Ratko Mileva"},{"name":"李 雪飛"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"伊藤 孝司"},{"name":"細井 和雄"}]},"event":{"en":"The 1st International Symposium and Workshop on The Future Direction of Oral Sciences in The 21st Century, organized by Bando, E.","ja":"The 1st International Symposium and Workshop on The Future Direction of Oral Sciences in The 21st Century, organized by Bando, E."},"publication_date":"2007-03","languages":["eng"],"location":{"en":"Awaji","ja":"Awaji"},"is_international_presentation":true},"priority":"input_data"}
line:24, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817460"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383096","label":"url"}],"presentation_title":{"en":"Molecular and cellular analyses of mutant AQP5 which occurred naturally in Spraque - Dawley rats","ja":"Molecular and cellular analyses of mutant AQP5 which occurred naturally in Spraque - Dawley rats"},"presenters":{"en":[{"name":"Karabasil R. Mileva"},{"name":"Hasegawa Takahiro"},{"name":"Purwanti Nunuk"},{"name":"Murdiastuti Kwartarini"},{"name":"Li Xuefei"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Karabasil R. Mileva"},{"name":"長谷川 敬展"},{"name":"Purwanti Nunuk"},{"name":"Murdiastuti Kwartarini"},{"name":"李 雪飛"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"3rd International Symposium on Salivary Glands in Honor of Niels Stensen","ja":"3rd International Symposium on Salivary Glands in Honor of Niels Stensen"},"publication_date":"2006-10","languages":["eng"],"location":{"en":"Okazaki, Japan","ja":"Okazaki, Japan"},"is_international_presentation":true},"priority":"input_data"}
line:25, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817461"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383095","label":"url"}],"presentation_title":{"en":"Effects of autonomic denervation and administration of SNI-2011 on the expression of AQPs in the rat salivary gland","ja":"Effects of autonomic denervation and administration of SNI-2011 on the expression of AQPs in the rat salivary gland"},"presenters":{"en":[{"name":"Li Xuefei"},{"name":"Karabasil R. Mileva"},{"name":"Purwanti Nunuk"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"李 雪飛"},{"name":"カラバシル ミレーバ"},{"name":"プルワンティ ヌヌク"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"The 3rd International Symposium on Salivary Glands in honor of Niels Stensen","ja":"The 3rd International Symposium on Salivary Glands in honor of Niels Stensen"},"publication_date":"2006-10","languages":["eng"],"location":{"en":"Okazaki, Japan","ja":"Okazaki, Japan"},"is_international_presentation":true},"priority":"input_data"}
line:26, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817462"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383094","label":"url"}],"presentation_title":{"en":"Tissue kallikrein mK13 is a candidate of the processing enzyme for pro-IL-1β in the mouse submandibular gland","ja":"Tissue kallikrein mK13 is a candidate of the processing enzyme for pro-IL-1β in the mouse submandibular gland"},"presenters":{"en":[{"name":"Yao Chenjuan"},{"name":"Karabasil R. Mileva"},{"name":"Purwanti Nunuk"},{"name":"Li Xuefei"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"姚 陳娟"},{"name":"カラバシル ミレーバ"},{"name":"プルワンティ ヌヌク"},{"name":"李 雪飛"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"The 3rd International Symposium on Salivary Glands in honor of Niels Stensen","ja":"The 3rd International Symposium on Salivary Glands in honor of Niels Stensen"},"publication_date":"2006-10","languages":["eng"],"location":{"en":"Okazaki, Japan","ja":"Okazaki, Japan"},"is_international_presentation":true},"priority":"input_data"}
line:27, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817463"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383093","label":"url"}],"presentation_title":{"en":"Involvement of a subtilisin-like proprotein convertase, PACE4, in branching morphogenesis and AQP5 expression in the rat embryonic submandibular gland.","ja":"Involvement of a subtilisin-like proprotein convertase, PACE4, in branching morphogenesis and AQP5 expression in the rat embryonic submandibular gland."},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Purwanti Nunuk"},{"name":"Karabasil R. Mileva"},{"name":"Li Xuefei"},{"name":"Yao Chenjuan"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"赤松 徹也"},{"name":"プルワンティ ヌヌク"},{"name":"カラバシル ミレーバ"},{"name":"李 雪飛"},{"name":"姚 陳娟"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"The 3rd International Symposium on Salivary Glands in honor of Niels Stensen","ja":"The 3rd International Symposium on Salivary Glands in honor of Niels Stensen"},"publication_date":"2006-10","languages":["eng"],"location":{"en":"Okazaki, Japan","ja":"Okazaki, Japan"},"is_international_presentation":true},"priority":"input_data"}
line:28, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817464"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=161682","label":"url"}],"presentation_title":{"en":"The expression of cellular markers of duct/acini and side population dynamics in the duct-ligated mouse submandibular gland.","ja":"The expression of cellular markers of duct/acini and side population dynamics in the duct-ligated mouse submandibular gland."},"presenters":{"en":[{"name":"Purwanti Nunuk"},{"name":"Tsuji Daisuke"},{"name":"Karabasil Ratko Mileva"},{"name":"Li Xuefei"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Itou Kouji"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Purwanti Nunuk"},{"name":"辻 大輔"},{"name":"Karabasil Ratko Mileva"},{"name":"李 雪飛"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"伊藤 孝司"},{"name":"細井 和雄"}]},"event":{"en":"3rd International Symposium on Salivary Glands in Honor of Niels Stensen","ja":"3rd International Symposium on Salivary Glands in Honor of Niels Stensen"},"publication_date":"2006-10","languages":["eng"],"location":{"en":"Okazaki","ja":"Okazaki"},"is_international_presentation":true},"priority":"input_data"}
line:29, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817465"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383088","label":"url"}],"presentation_title":{"en":"Proteolytic processing of the precursor of interleukin-1β by tissue kallikrein mK13 in the submandibular gland of mice.","ja":"Proteolytic processing of the precursor of interleukin-1β by tissue kallikrein mK13 in the submandibular gland of mice."},"presenters":{"en":[{"name":"Yao Chenjuan"},{"name":"Karabasil R. Mileva"},{"name":"Purwanti Nunuk"},{"name":"Li Xuefei"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"姚 陳娟"},{"name":"カラバシル ミレーバ"},{"name":"プルワンティ ヌヌク"},{"name":"李 雪飛"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"International symposium on \"Medical and Biological Perspectives in Proteases and Their Inhibitors\", Satellite meeting of the 20th IUBMB International Congress of Biochemistry and Molecular Biology & the 11th FAOBMB Congress","ja":"International symposium on \"Medical and Biological Perspectives in Proteases and Their Inhibitors\", Satellite meeting of the 20th IUBMB International Congress of Biochemistry and Molecular Biology & the 11th FAOBMB Congress"},"publication_date":"2006-06","languages":["eng"],"location":{"en":"Awaji, Japan","ja":"Awaji, Japan"},"is_international_presentation":true},"priority":"input_data"}
line:30, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817466"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383087","label":"url"}],"presentation_title":{"en":"Inhibition of subtilisin-like proprotein convertase PACE4 reduces the branching morphogenesis and expression of AQP5 in the organ culture system of rat embryonic submandibular gland","ja":"Inhibition of subtilisin-like proprotein convertase PACE4 reduces the branching morphogenesis and expression of AQP5 in the organ culture system of rat embryonic submandibular gland"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Purwanti Nunuk"},{"name":"Karabasil R. Mileva"},{"name":"Li Xuefei"},{"name":"Yao Chenjuan"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"赤松 徹也"},{"name":"プルワンティ ヌヌク"},{"name":"カラバシル ミレーバ"},{"name":"李 雪飛"},{"name":"姚 陳娟"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"International symposium on \"Medical and Biological Perspectives in Proteases and Their Inhibitors\", Satellite meeting of the 20th IUBMB International Congress of Biochemistry and Molecular Biology & the 11th FAOBMB Congress","ja":"International symposium on \"Medical and Biological Perspectives in Proteases and Their Inhibitors\", Satellite meeting of the 20th IUBMB International Congress of Biochemistry and Molecular Biology & the 11th FAOBMB Congress"},"publication_date":"2006-06","languages":["eng"],"location":{"en":"Awaji, Japan","ja":"Awaji, Japan"},"is_international_presentation":true},"priority":"input_data"}
line:31, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817467"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383086","label":"url"}],"presentation_title":{"en":"Inhibition of subtilisin-like proprotein convertase PACE4 reduces the branching morphogenesis and expression of AQP5 in the organ culture system of rat embryonic submandibular gland","ja":"サチライシン様前駆体蛋白質変換酵素PACE4の阻害はラット胎仔顎下腺の分枝形成とAQP5発現を抑制する"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Purwanti Nunuk"},{"name":"Karabasil R. Mileva"},{"name":"Li Xuefei"},{"name":"Yao Chenjuan"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"赤松 徹也"},{"name":"プルワンティ ヌヌク"},{"name":"カラバシル ミレーバ"},{"name":"李 雪飛"},{"name":"姚 陳娟"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"20th IUBMB International Congress of Biochemistry and Molecular Biology & 11th FAOBMB Congress, 第79回日本生化学会大会 & 第29回日本分子生物学会年会, also 第59回日本細胞生物学会大会","ja":"20th IUBMB International Congress of Biochemistry and Molecular Biology & 11th FAOBMB Congress, 第79回日本生化学会大会 & 第29回日本分子生物学会年会, also 第59回日本細胞生物学会大会"},"publication_date":"2006-06","location":{"en":"Kyoto","ja":"京都"},"is_international_presentation":true},"priority":"input_data"}
line:32, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817468"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383077","label":"url"}],"presentation_title":{"en":"Induction, processing, and secretion of IL-1βin the submandibular gland of mice","ja":"Induction, processing, and secretion of IL-1βin the submandibular gland of mice"},"presenters":{"en":[{"name":"Yao Chenjuan"},{"name":"Li Xuefei"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"姚 陳娟"},{"name":"李 雪飛"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"The 35th International Congress of Physiological Sciences (IUPS2005) and Experimental Biology 2005","ja":"The 35th International Congress of Physiological Sciences (IUPS2005) and Experimental Biology 2005"},"publication_date":"2005-03","languages":["eng"],"location":{"en":"San Diego","ja":"San Diego"},"is_international_presentation":true},"priority":"input_data"}
line:33, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817469"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383076","label":"url"}],"presentation_title":{"en":"ECM-bound proprotein convertase PACE4 is involved in the branching morphogenesis of rat submandibular gland","ja":"ECM-bound proprotein convertase PACE4 is involved in the branching morphogenesis of rat submandibular gland"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Yao Chenjuan"},{"name":"Li Xuefei"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"赤松 徹也"},{"name":"姚 陳娟"},{"name":"李 雪飛"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"The 35th International Congress of Physiological Sciences (IUPS2005) and Experimental Biology 2005","ja":"The 35th International Congress of Physiological Sciences (IUPS2005) and Experimental Biology 2005"},"publication_date":"2005-03","languages":["eng"],"location":{"en":"San Diego","ja":"San Diego"},"is_international_presentation":true},"priority":"input_data"}
line:34, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817470"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383048","label":"url"}],"presentation_title":{"en":"Mast cell kininogen and salivary gland kallikrein-kinin system","ja":"肥満細胞キニノーゲンと唾液腺カリクレイン-キニン系"},"presenters":{"en":[{"name":"Hosoi Kazuo"},{"name":"松浦 幸子"},{"name":"倉淵 真悟"},{"name":"津村 恵子"},{"name":"多田 淳"},{"name":"澤 孝賢"},{"name":"Kanamori Norio"},{"name":"Akamatsu Tetsuya"}],"ja":[{"name":"細井 和雄"},{"name":"松浦 幸子"},{"name":"倉淵 真悟"},{"name":"津村 恵子"},{"name":"多田 淳"},{"name":"澤 孝賢"},{"name":"金森 憲雄"},{"name":"赤松 徹也"}]},"event":{"en":"The 1st meeting for international collaborative research project 1998-2000.","ja":"The 1st meeting for international collaborative research project 1998-2000."},"publication_date":"1999-01","location":{"en":"愛知","ja":"愛知"},"is_international_presentation":true},"priority":"input_data"}
line:35, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550683"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=72120","label":"url"}],"presentation_title":{"en":"Salivary gland tissue kallikrein family and processing of growth factor precursors and proenzymes.","ja":"Salivary gland tissue kallikrein family and processing of growth factor precursors and proenzymes."},"presenters":{"en":[{"name":"Hosoi Kazuo"},{"name":"Kurabuchi, Shingo"},{"name":"Kikkawa, Yamato"},{"name":"Tada, Jun"},{"name":"Akamatsu Tetsuya"},{"name":"Yamanaka, Naoki"},{"name":"Matsumoto, Takuya"},{"name":"Kanamori Norio"},{"name":"Tsumura Keiko"}],"ja":[{"name":"細井 和雄"},{"name":"Kurabuchi, Shingo"},{"name":"Kikkawa, Yamato"},{"name":"Tada, Jun"},{"name":"赤松 徹也"},{"name":"Yamanaka, Naoki"},{"name":"Matsumoto, Takuya"},{"name":"金森 憲雄"},{"name":"津村 恵子"}]},"event":{"en":"European Journal of Morphology","ja":"European Journal of Morphology"},"publication_date":"1998-08","languages":["eng"],"location":{"en":"Cagliari, Italy","ja":"Cagliari, Italy"},"description":{"en":"マウスの唾液腺(顎下腺)から得られる主要な組織カリクレインを同定しこれら酵素の有する成長因子前駆体プロセッシング活性について調べた．本研究ではこれら酵素の基質として天然の基質蛋白質(キニノゲン，およびプロレニン)に加えて各種合成基質を用いた．その結果，キニノーゲナーゼ活性の弱い組織カリクレインほど強いプロレニン変換活性を示すことがあきらかになった．","ja":"マウスの唾液腺(顎下腺)から得られる主要な組織カリクレインを同定しこれら酵素の有する成長因子前駆体プロセッシング活性について調べた．本研究ではこれら酵素の基質として天然の基質蛋白質(キニノゲン，およびプロレニン)に加えて各種合成基質を用いた．その結果，キニノーゲナーゼ活性の弱い組織カリクレインほど強いプロレニン変換活性を示すことがあきらかになった．"},"is_international_presentation":true},"priority":"input_data"}
line:36, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817471"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383043","label":"url"}],"presentation_title":{"en":"A novel human PACE4 isoform, PACE4E, is an active protease containing a hydrophobic cluster at the carboxy terminus","ja":"A novel human PACE4 isoform, PACE4E, is an active protease containing a hydrophobic cluster at the carboxy terminus"},"presenters":{"en":[{"name":"Mori Kenji"},{"name":"今牧 明義"},{"name":"Akamatsu Tetsuya"},{"name":"Tsuji Akihiko"},{"name":"Nagahama Masami"},{"name":"Matsuda Yoshiko"}],"ja":[{"name":"森 健二"},{"name":"今牧 明義"},{"name":"赤松 徹也"},{"name":"辻 明彦"},{"name":"長浜 正巳"},{"name":"松田 佳子"}]},"event":{"en":"17th International Congress of Biochemistry and Molecular Biology","ja":"17th International Congress of Biochemistry and Molecular Biology"},"publication_date":"1997-08-24","languages":["eng"],"location":{"en":"San Francisco","ja":"San Francisco"},"is_international_presentation":true},"priority":"input_data"}
line:37, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817472"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=17299","label":"url"}],"presentation_title":{"en":"Gene organization and Alternative Splicing of Human PACE4, Subtilisin-Like Proprotein Convertase","ja":"Gene organization and Alternative Splicing of Human PACE4, Subtilisin-Like Proprotein Convertase"},"presenters":{"en":[{"name":"Tsuji Akihiko"},{"name":"Hine Chiemi"},{"name":"Yoshida Shigeru"},{"name":"Bando Miwa"},{"name":"Mori Kenji"},{"name":"Akamatsu Tetsuya"},{"name":"Matsuda Yoshiko"}],"ja":[{"name":"辻 明彦"},{"name":"Hine Chiemi"},{"name":"Yoshida Shigeru"},{"name":"Bando Miwa"},{"name":"Mori Kenji"},{"name":"赤松 徹也"},{"name":"松田 佳子"}]},"event":{"en":"17th International Congress of Biochemistry and Molecular Biology, FASEB.J.","ja":"17th International Congress of Biochemistry and Molecular Biology, FASEB.J."},"publication_date":"1997-08-24","languages":["eng"],"location":{"en":"San Francisco","ja":"San Francisco"},"is_international_presentation":true},"priority":"input_data"}
line:38, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550684"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=120400","label":"url"}],"presentation_title":{"en":"Cyclic AMP-inducible procalcitonin processing in thyroidal parafollicular cells is regulated by the Kexin family protease, PC1.","ja":"Cyclic AMP-inducible procalcitonin processing in thyroidal parafollicular cells is regulated by the Kexin family protease, PC1."},"presenters":{"en":[{"name":"Nagamune Hideaki"},{"name":"Muramatsu Kazuaki"},{"name":"Higashine Masakatsu"},{"name":"Akamatsu Tetsuya"},{"name":"Tamai Yasuhiro"},{"name":"Yonetomi Yasuo"},{"name":"Tsuji Akihiko"},{"name":"Izumi Keisuke"},{"name":"Sakaguchi Takemasa"},{"name":"Yoshida Tetsuya"},{"name":"Matsuda Yoshiko"}],"ja":[{"name":"長宗 秀明"},{"name":"Muramatsu Kazuaki"},{"name":"Higashine Masakatsu"},{"name":"赤松 徹也"},{"name":"Tamai Yasuhiro"},{"name":"Yonetomi Yasuo"},{"name":"辻 明彦"},{"name":"泉 啓介"},{"name":"Sakaguchi Takemasa"},{"name":"Yoshida Tetsuya"},{"name":"松田 佳子"}]},"event":{"en":"International Symposium on Medical Aspects of Protease Inhibitors; In \"Medical Aspects of Proteases and Protease Inhibitors\": Biomedical and Health Research","ja":"International Symposium on Medical Aspects of Protease Inhibitors; In \"Medical Aspects of Proteases and Protease Inhibitors\": Biomedical and Health Research"},"publication_date":"1997-05","languages":["eng"],"promoter":{"en":"IOS Press","ja":"IOS Press"},"location":{"en":"Amsterdam","ja":"Amsterdam"},"description":{"en":"ラット甲状腺においてKexin様プロテアーゼの免疫組織化学的解析を行った．その結果，カルシトニンを作る傍濾胞細胞ではPC1とPC2が強く発現しており，FurinやPC6の発現はわずかで，PACE4は検出できなかった．傍濾胞細胞株TTのウエスタンブロットでもPC1，PC2， Furin，PC6は検出されたが，cAMP刺激による成熟カルシトニン量の上昇と連動して急増する酵素はPC1だけであり，cAMP刺激に応答してカルシトニン量を制御するKexin様プロテアーゼはPC1である事を示した．","ja":"ラット甲状腺においてKexin様プロテアーゼの免疫組織化学的解析を行った．その結果，カルシトニンを作る傍濾胞細胞ではPC1とPC2が強く発現しており，FurinやPC6の発現はわずかで，PACE4は検出できなかった．傍濾胞細胞株TTのウエスタンブロットでもPC1，PC2， Furin，PC6は検出されたが，cAMP刺激による成熟カルシトニン量の上昇と連動して急増する酵素はPC1だけであり，cAMP刺激に応答してカルシトニン量を制御するKexin様プロテアーゼはPC1である事を示した．"},"is_international_presentation":true},"priority":"input_data"}
line:39, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817473"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383041","label":"url"}],"presentation_title":{"en":"Expression of a novel PACE4 isoform, PACE4E, in developmental rat brain","ja":"ラット脳発生過程における新規PACE4アイソフォーム,PACE4Eの発現"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"吉田 茂"},{"name":"大黒 成夫"},{"name":"Nagamune Hideaki"},{"name":"長濱 正巳"},{"name":"Tsuji Akihiko"},{"name":"Matsuda Yoshiko"}],"ja":[{"name":"赤松 徹也"},{"name":"吉田 茂"},{"name":"大黒 成夫"},{"name":"長宗 秀明"},{"name":"長濱 正巳"},{"name":"辻 明彦"},{"name":"松田 佳子"}]},"event":{"en":"The 12th International Symposium of Federation of Asian and Oceanian Biochemists and Molecular Biologists","ja":"The 12th International Symposium of Federation of Asian and Oceanian Biochemists and Molecular Biologists"},"publication_date":"1996-06","location":{"en":"Tokushima","ja":"徳島"},"is_international_presentation":true},"priority":"input_data"}
line:40, {"insert":{"user_id":"1000223301","type":"presentations","id":"43049173"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=400064","label":"url"}],"presentation_title":{"en":"コオロギ食が唾液腺機能に及ぼす効果の検証","ja":"コオロギ食が唾液腺機能に及ぼす効果の検証"},"presenters":{"en":[{"name":"平田 愛佳"},{"name":"佐藤 匠"},{"name":"増田 尚輝"},{"name":"Yao Chenjuan"},{"name":"Mukai Rie"},{"name":"Watanabe Takahito"},{"name":"Mito Taro"},{"name":"Akamatsu Tetsuya"}],"ja":[{"name":"平田 愛佳"},{"name":"佐藤 匠"},{"name":"増田 尚輝"},{"name":"姚 陳娟"},{"name":"向井 理恵"},{"name":"渡辺 崇人"},{"name":"三戸 太郎"},{"name":"赤松 徹也"}]},"event":{"en":"第1回唾液ケア研究会学術集会","ja":"第1回唾液ケア研究会学術集会"},"publication_date":"2022-11-27","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:41, {"insert":{"user_id":"1000223301","type":"presentations","id":"43049174"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=400063","label":"url"}],"presentation_title":{"en":"食品成分が唾液腺機能に及ぼす影響","ja":"食品成分が唾液腺機能に及ぼす影響"},"presenters":{"en":[{"name":"平田 愛佳"},{"name":"佐藤 匠"},{"name":"田中 寛人"},{"name":"増田 尚輝"},{"name":"Yao Chenjuan"},{"name":"Mukai Rie"},{"name":"Hasegawa Takahiro"},{"name":"Yoshimura Hiroshi"},{"name":"Watanabe Takahito"},{"name":"Mito Taro"},{"name":"Akamatsu Tetsuya"}],"ja":[{"name":"平田 愛佳"},{"name":"佐藤 匠"},{"name":"田中 寛人"},{"name":"増田 尚輝"},{"name":"姚 陳娟"},{"name":"向井 理恵"},{"name":"長谷川 敬展"},{"name":"吉村 弘"},{"name":"渡辺 崇人"},{"name":"三戸 太郎"},{"name":"赤松 徹也"}]},"event":{"en":"第34回唾液腺談話会","ja":"第34回唾液腺談話会"},"publication_date":"2022-09-16","invited":true,"languages":["jpn"],"location":{"en":"Tokushima","ja":"徳島"},"is_international_presentation":false},"priority":"input_data"}
line:42, {"insert":{"user_id":"1000223301","type":"presentations","id":"36201537"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383750","label":"url"}],"presentation_title":{"en":"一般選抜後期日程における入学辞退率改善の取り組みーー徳島大学B学部の事例からーー","ja":"一般選抜後期日程における入学辞退率改善の取り組みーー徳島大学B学部の事例からーー"},"presenters":{"en":[{"name":"Ueno Yoshihiko"},{"name":"Sakuradani Eiji"},{"name":"Seki Yosuke"},{"name":"Kamioka Maiko"},{"name":"Asada Chikako"},{"name":"Akamatsu Tetsuya"},{"name":"Miyawaki Katsuyuki"},{"name":"Uto Yoshihiro"},{"name":"Tanaka Tamotsu"}],"ja":[{"name":"植野 美彦"},{"name":"櫻谷 英治"},{"name":"関 陽介"},{"name":"上岡 麻衣子"},{"name":"浅田 元子"},{"name":"赤松 徹也"},{"name":"宮脇 克行"},{"name":"宇都 義浩"},{"name":"田中 保"}]},"event":{"en":"第17回大学教育カンファレンスin徳島","ja":"第17回大学教育カンファレンスin徳島"},"publication_date":"2022-01-07","languages":["jpn"],"location":{"en":"Online","ja":"オンライン"},"is_international_presentation":false},"priority":"input_data"}
line:43, {"insert":{"user_id":"1000223301","type":"presentations","id":"36266338"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=384016","label":"url"}],"presentation_title":{"en":"マウス唾液腺AQP5発現に及ぼす高脂肪食および低タンパク質食摂取の影響","ja":"マウス唾液腺AQP5発現に及ぼす高脂肪食および低タンパク質食摂取の影響"},"presenters":{"en":[{"name":"平田 愛佳"},{"name":"佐藤 匠"},{"name":"田中 寛人"},{"name":"小西 冴季"},{"name":"Yao Chenjuan"},{"name":"Mukai Rie"},{"name":"Akamatsu Tetsuya"}],"ja":[{"name":"平田 愛佳"},{"name":"佐藤 匠"},{"name":"田中 寛人"},{"name":"小西 冴季"},{"name":"姚 陳娟"},{"name":"向井 理恵"},{"name":"赤松 徹也"}]},"event":{"en":"第63回歯科基礎医学会学術大会","ja":"第63回歯科基礎医学会学術大会"},"publication_date":"2021-10-09","languages":["jpn"],"location":{"en":"徳島県徳島市(徳島大学)","ja":"徳島県徳島市(徳島大学)"},"is_international_presentation":false},"priority":"input_data"}
line:44, {"insert":{"user_id":"1000223301","type":"presentations","id":"39705162"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=390833","label":"url"}],"presentation_title":{"en":"周辺環境が主観的感覚および摂食行動に及ぼす影響:筋電図を用いた研究","ja":"周辺環境が主観的感覚および摂食行動に及ぼす影響:筋電図を用いた研究"},"presenters":{"en":[{"name":"Fukuda Takako"},{"name":"KUSUNOKI Shintaroh"},{"name":"前田 さおり"},{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"福田 崇子"},{"name":"楠 進太郎"},{"name":"前田 さおり"},{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"吉村 弘"}]},"event":{"en":"日本味と匂学会第55回大会","ja":"日本味と匂学会第55回大会"},"publication_date":"2021-09-22","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:45, {"insert":{"user_id":"1000223301","type":"presentations","id":"39296853"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=387514","label":"url"}],"presentation_title":{"en":"Relationship between brain activities and feeding behavior under comfortable and uncomfortable environments.","ja":"快・不快環境下における脳活動と摂食行動の関連性"},"presenters":{"en":[{"name":"Shintaro Kusunoki"},{"name":"Takako Fukuda"},{"name":"Saori Maeda"},{"name":"Yao Chenjuan"},{"name":"Hasegawa Takahiro"},{"name":"Akamatsu Tetsuya"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"楠 進太郎"},{"name":"福田 崇子"},{"name":"前田 さおり"},{"name":"姚 陳娟"},{"name":"長谷川 敬展"},{"name":"赤松 徹也"},{"name":"吉村 弘"}]},"event":{"en":"第55回日本味と匂い学会","ja":"第55回日本味と匂い学会"},"publication_date":"2021-09-22","languages":["jpn"],"location":{"en":"Fukuoka","ja":"福岡"},"is_international_presentation":false},"priority":"input_data"}
line:46, {"insert":{"user_id":"1000223301","type":"presentations","id":"36266339"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=384014","label":"url"}],"presentation_title":{"en":"高脂肪食や低タンパク質食が引き起こすマウス唾液腺AQP5発現・局在変化","ja":"高脂肪食や低タンパク質食が引き起こすマウス唾液腺AQP5発現・局在変化"},"presenters":{"en":[{"name":"平田 愛佳"},{"name":"佐藤 匠"},{"name":"田中 寛人"},{"name":"小西 冴季"},{"name":"Yao Chenjuan"},{"name":"Mukai Rie"},{"name":"Akamatsu Tetsuya"}],"ja":[{"name":"平田 愛佳"},{"name":"佐藤 匠"},{"name":"田中 寛人"},{"name":"小西 冴季"},{"name":"姚 陳娟"},{"name":"向井 理恵"},{"name":"赤松 徹也"}]},"event":{"en":"第75回日本栄養・食糧学会大会","ja":"第75回日本栄養・食糧学会大会"},"publication_date":"2021-07-03","languages":["jpn"],"location":{"en":"東京オンライン開催","ja":"東京オンライン開催"},"is_international_presentation":false},"priority":"input_data"}
line:47, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550689"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=378267","label":"url"}],"presentation_title":{"en":"Localization of subtilisin-like proprotein convertase PACE4 in the course of development of the rat submandibular gland","ja":"サチライシン様前駆体蛋白質変換酵素PACE4のラット顎下腺発生過程における局在"},"presenters":{"en":[{"name":"Takumi SATOH"},{"name":"Yao Chenjuan"},{"name":"Hasegawa Takahiro"},{"name":"Yoshimura Hiroshi"},{"name":"Akamatsu Tetsuya"}],"ja":[{"name":"佐藤 匠"},{"name":"姚 陳娟"},{"name":"長谷川 敬展"},{"name":"吉村 弘"},{"name":"赤松 徹也"}]},"event":{"en":"第62回歯科基礎医学会学術大会","ja":"第62回歯科基礎医学会学術大会"},"publication_date":"2020-09","languages":["jpn"],"location":{"en":"Online","ja":"オンライン"},"is_international_presentation":false},"priority":"input_data"}
line:48, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550685"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=378262","label":"url"}],"presentation_title":{"en":"Localization of subtilisin-like proprotein convertase PACE4 during development of the rat salivary gland","ja":"ラット唾液腺発生過程におけるサチライシン様前駆体蛋白質変換酵素PACE4の局在"},"presenters":{"en":[{"name":"Takumi SATOH"},{"name":"Yao Chenjuan"},{"name":"Hasegawa Takahiro"},{"name":"Yoshimura Hiroshi"},{"name":"Akamatsu Tetsuya"}],"ja":[{"name":"佐藤 匠"},{"name":"姚 陳娟"},{"name":"長谷川 敬展"},{"name":"吉村 弘"},{"name":"赤松 徹也"}]},"event":{"en":"第93回日本生化学会大会","ja":"第93回日本生化学会大会"},"publication_date":"2020-09","languages":["jpn"],"location":{"en":"Online","ja":"オンライン"},"is_international_presentation":false},"priority":"input_data"}
line:49, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550690"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=358276","label":"url"}],"presentation_title":{"en":"Increase in theta-band EEG activities under tasting chocolate with unmatched odor stimulation","ja":"Increase in theta-band EEG activities under tasting chocolate with unmatched odor stimulation"},"presenters":{"en":[{"name":"Saori Maeda"},{"name":"Yoshimura Hiroshi"},{"name":"Yuji Miyaji"},{"name":"Kanayama Hiroyuki"},{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"}],"ja":[{"name":"前田 さおり"},{"name":"吉村 弘"},{"name":"宮地"},{"name":"金山 宏幸"},{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"}]},"event":{"en":"第41回日本神経科学大会","ja":"第41回日本神経科学大会"},"publication_date":"2018-07-27","languages":["eng"],"location":{"en":"Kobe","ja":"Kobe"},"is_international_presentation":false},"priority":"input_data"}
line:50, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550691"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=345125","label":"url"}],"presentation_title":{"en":"Theta band brain activity during checking the unmatched olfactory-taste information","ja":"匂いと味の不一致が引き起こすシータ波領域脳活動"},"presenters":{"en":[{"name":"前田 さおり"},{"name":"Yoshimura Hiroshi"},{"name":"宮地 裕司"},{"name":"金山 宏幸"},{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"}],"ja":[{"name":"前田 さおり"},{"name":"吉村 弘"},{"name":"宮地 裕司"},{"name":"金山 宏幸"},{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"}]},"event":{"en":"第95回日本生理学大会","ja":"第95回日本生理学大会"},"publication_date":"2018-03-28","location":{"en":"Takamatsu","ja":"高松"},"is_international_presentation":false},"priority":"input_data"}
line:51, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550692"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=342703","label":"url"}],"presentation_title":{"en":"甘味とニオイのミスマッチが甘味認知に与える影響","ja":"甘味とニオイのミスマッチが甘味認知に与える影響"},"presenters":{"en":[{"name":"前田 さおり"},{"name":"宮地 裕司"},{"name":"金山 宏幸"},{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"前田 さおり"},{"name":"宮地 裕司"},{"name":"金山 宏幸"},{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"吉村 弘"}]},"event":{"en":"第69回日本生理学会中国・四国地方会","ja":"第69回日本生理学会中国・四国地方会"},"publication_date":"2017-10-29","languages":["jpn"],"location":{"en":"Tokushima","ja":"徳島"},"is_international_presentation":false},"priority":"input_data"}
line:52, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550693"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=342700","label":"url"}],"presentation_title":{"en":"唾液腺再生モデルにおける雌雄差の影響","ja":"唾液腺再生モデルにおける雌雄差の影響"},"presenters":{"en":[{"name":"Hata Mio"},{"name":"Akamatsu Tetsuya"},{"name":"Yao Chenjuan"},{"name":"前田 さおり"},{"name":"宮地 裕司"},{"name":"金山 宏幸"},{"name":"Hasegawa Takahiro"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"畑 美緒"},{"name":"赤松 徹也"},{"name":"姚 陳娟"},{"name":"前田 さおり"},{"name":"宮地 裕司"},{"name":"金山 宏幸"},{"name":"長谷川 敬展"},{"name":"吉村 弘"}]},"event":{"en":"第69回日本生理学会中国・四国地方会","ja":"第69回日本生理学会中国・四国地方会"},"publication_date":"2017-10-28","languages":["jpn"],"location":{"en":"Tokushima","ja":"徳島"},"is_international_presentation":false},"priority":"input_data"}
line:53, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550694"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=345123","label":"url"}],"presentation_title":{"en":"Influences of Match/Mismatch of taste and odor on taste perception: An electroencephalogram frequency analysis study","ja":"味と匂いのミスマッチが味覚認知に与える影響:脳波周波数分析を用いた研究"},"presenters":{"en":[{"name":"前田 さおり"},{"name":"Yoshimura Hiroshi"},{"name":"宮地 ゆうじ"},{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"}],"ja":[{"name":"前田 さおり"},{"name":"吉村 弘"},{"name":"宮地 ゆうじ"},{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"}]},"event":{"en":"日本味と匂学会第51回大会","ja":"日本味と匂学会第51回大会"},"publication_date":"2017-09-26","location":{"en":"Kobe","ja":"神戸"},"is_international_presentation":false},"priority":"input_data"}
line:54, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550695"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=345119","label":"url"}],"presentation_title":{"en":"カフェイン投与により誘発される視覚野オシレーション におけるnon-NMDA受容体とNMDA受容体の相互交錯的関与","ja":"カフェイン投与により誘発される視覚野オシレーション におけるnon-NMDA受容体とNMDA受容体の相互交錯的関与"},"presenters":{"en":[{"name":"Yoshimura Hiroshi"},{"name":"須貝 外喜夫"},{"name":"加藤 伸郎"},{"name":"冨永 貴志"},{"name":"冨永 洋子"},{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"}],"ja":[{"name":"吉村 弘"},{"name":"須貝 外喜夫"},{"name":"加藤 伸郎"},{"name":"冨永 貴志"},{"name":"冨永 洋子"},{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"}]},"event":{"en":"第40回日本神経科学大会","ja":"第40回日本神経科学大会"},"publication_date":"2017-07-21","location":{"en":"Makuhari","ja":"幕張"},"is_international_presentation":false},"priority":"input_data"}
line:55, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550696"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=332301","label":"url"}],"presentation_title":{"en":"Influences of olfactory stimulation on taste perception: An electroencephalogram frequency analysis study","ja":"Influences of olfactory stimulation on taste perception: An electroencephalogram frequency analysis study"},"presenters":{"en":[{"name":"Saori Maeda"},{"name":"Yuki Miyachi"},{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"Saori Maeda"},{"name":"Yuki Miyachi"},{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"吉村 弘"}]},"event":{"en":"The 94th Annual Meeting of the Physiological Science of Japan","ja":"The 94th Annual Meeting of the Physiological Science of Japan"},"publication_date":"2017-03-29","languages":["eng"],"is_international_presentation":false},"priority":"input_data"}
line:56, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550697"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=329980","label":"url"}],"presentation_title":{"en":"Sexual difference in regeneration of salivary gland","ja":"唾液腺再生過程で見られる雌雄差について"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Yao Chenjuan"},{"name":"Hasegawa Takahiro"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"赤松 徹也"},{"name":"姚 陳娟"},{"name":"長谷川 敬展"},{"name":"吉村 弘"}]},"event":{"en":"第58回歯科基礎医学会学術大会","ja":"第58回歯科基礎医学会学術大会"},"publication_date":"2016-08-26","languages":["jpn"],"location":{"en":"Sapporo","ja":"札幌"},"is_international_presentation":false},"priority":"input_data"}
line:57, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550698"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=330488","label":"url"}],"presentation_title":{"en":"Induction of a subtilisin-like proprotein convertase PACE4 in regeneration model of salivary gland Part II","ja":"唾液腺再生モデルにおけるサチライシン様前駆体蛋白質変換酵素PACE4の発現誘導-Part II-"},"presenters":{"en":[{"name":"Shimatani Tatsuya"},{"name":"Minegishi Makoto"},{"name":"Akamatsu Tetsuya"},{"name":"Yao Chenjuan"},{"name":"Hasegawa Takahiro"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"嶋谷 達哉"},{"name":"嶺岸 誠"},{"name":"赤松 徹也"},{"name":"姚 陳娟"},{"name":"長谷川 敬展"},{"name":"吉村 弘"}]},"event":{"en":"第58回歯科基礎医学会学術大会","ja":"第58回歯科基礎医学会学術大会"},"publication_date":"2016-08-25","languages":["jpn"],"location":{"en":"Sapporo","ja":"札幌"},"is_international_presentation":false},"priority":"input_data"}
line:58, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550699"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=320228","label":"url"}],"presentation_title":{"en":"Influences of oral impairment on neural oscilltion and wave propagation in the neocortex of rats","ja":"Influences of oral impairment on neural oscilltion and wave propagation in the neocortex of rats"},"presenters":{"en":[{"name":"Yoshimura Hiroshi"},{"name":"川邊 真道"},{"name":"須貝 外喜夫"},{"name":"加藤 伸郎"},{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"}],"ja":[{"name":"吉村 弘"},{"name":"川邊 真道"},{"name":"須貝 外喜夫"},{"name":"加藤 伸郎"},{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"}]},"event":{"en":"第38回日本神経科学大会","ja":"第38回日本神経科学大会"},"publication_date":"2015-07","location":{"en":"Kobe","ja":"Kobe"},"is_international_presentation":false},"priority":"input_data"}
line:59, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550700"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=318187","label":"url"}],"presentation_title":{"en":"Structure and Function of the Salivary Gland","ja":"唾液腺の構造と機能"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"}],"ja":[{"name":"赤松 徹也"}]},"event":{"en":"第47回四国歯学会","ja":"第47回四国歯学会"},"publication_date":"2015-06-25","invited":true,"languages":["jpn"],"location":{"en":"Tokushima","ja":"徳島"},"is_international_presentation":false},"priority":"input_data"}
line:60, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550701"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=297048","label":"url"}],"presentation_title":{"en":"Expression of water channel AQP5 in regeneration model of salivary gland","ja":"唾液腺再生モデルにおける水チャネルAQP5の発現"},"presenters":{"en":[{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Hasegawa Takahiro"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"長谷川 敬展"},{"name":"吉村 弘"}]},"event":{"en":"第56回歯科基礎医学会","ja":"第56回歯科基礎医学会"},"publication_date":"2014-09-27","languages":["jpn"],"location":{"en":"福岡国際会議場, 福岡県","ja":"福岡国際会議場, 福岡県"},"is_international_presentation":false},"priority":"input_data"}
line:61, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550702"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=297047","label":"url"}],"presentation_title":{"en":"Enhanced ubiquitylation and downregulation of aquaporin-5 by ubiquitin ligases","ja":"ユビキチンリガーゼによるAQP5のユビキチン化亢進とダウンレギュレーション"},"presenters":{"en":[{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"吉村 弘"}]},"event":{"en":"第56回歯科基礎医学会","ja":"第56回歯科基礎医学会"},"publication_date":"2014-09-27","languages":["jpn"],"location":{"en":"福岡国際会議場, 福岡県","ja":"福岡国際会議場, 福岡県"},"is_international_presentation":false},"priority":"input_data"}
line:62, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550703"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=297043","label":"url"}],"presentation_title":{"en":"Induced expression of subtilisin-like proprotein convertase in regeneration model of salivary gland","ja":"唾液腺再生モデルにおけるサチライシン様前駆体蛋白質変換酵素の発現誘導"},"presenters":{"en":[{"name":"Makoto Minegishi"},{"name":"Akamatsu Tetsuya"},{"name":"Yao Chenjuan"},{"name":"Hasegawa Takahiro"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"嶺岸 誠"},{"name":"赤松 徹也"},{"name":"姚 陳娟"},{"name":"長谷川 敬展"},{"name":"吉村 弘"}]},"event":{"en":"第56回歯科基礎医学会(福岡国際会議場/福岡県)","ja":"第56回歯科基礎医学会(福岡国際会議場/福岡県)"},"publication_date":"2014-09-26","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:63, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550686"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=283417","label":"url"}],"presentation_title":{"en":"Involvment of subtilisin-like proprotein convertase PACE4 in regeneration of salivary gland","ja":"唾液腺再生におけるサチライシン様前駆体蛋白質変換酵素PACE4の関与"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Yao Chenjuan"},{"name":"Hasegawa Takahiro"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"赤松 徹也"},{"name":"姚 陳娟"},{"name":"長谷川 敬展"},{"name":"吉村 弘"}]},"event":{"en":"第55回歯科基礎医学会(2013年9月19日-21日)","ja":"第55回歯科基礎医学会(2013年9月19日-21日)"},"publication_date":"2013-09-19","languages":["jpn"],"location":{"en":"岡山コンベンションセンター/岡山県","ja":"岡山コンベンションセンター/岡山県"},"is_international_presentation":false},"priority":"input_data"}
line:64, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550704"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=281778","label":"url"}],"presentation_title":{"en":"ヒト唾液腺HSG細胞における構成的なAQP5の取り込み","ja":"ヒト唾液腺HSG細胞における構成的なAQP5の取り込み"},"presenters":{"en":[{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"吉村 弘"}]},"event":{"en":"第55回歯科基礎医学会[2013年9月19日(金)-21日(日)]","ja":"第55回歯科基礎医学会[2013年9月19日(金)-21日(日)]"},"publication_date":"2013-09-19","languages":["jpn"],"location":{"en":"岡山コンベンションセンター/岡山県","ja":"岡山コンベンションセンター/岡山県"},"is_international_presentation":false},"priority":"input_data"}
line:65, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550705"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=281776","label":"url"}],"presentation_title":{"en":"Involvment of subtilisin-like proprotein convertase PACE4 in regeneration of salivary gland","ja":"唾液腺再生におけるサチライシン様前駆体蛋白質変換酵素PACE4の関与"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Yao Chenjuan"},{"name":"Hasegawa Takahiro"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"赤松 徹也"},{"name":"姚 陳娟"},{"name":"長谷川 敬展"},{"name":"吉村 弘"}]},"event":{"en":"Journal of Oral Biosciences","ja":"Journal of Oral Biosciences"},"publication_date":"2013-09-19","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:66, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550687"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=281774","label":"url"}],"presentation_title":{"en":"Involvment of subtilisin-like proprotein convertase PACE4 in regeneration of salivary gland","ja":"唾液腺再生におけるサチライシン様前駆体蛋白質変換酵素PACE4の関与"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Yao Chenjuan"},{"name":"Hasegawa Takahiro"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"赤松 徹也"},{"name":"姚 陳娟"},{"name":"長谷川 敬展"},{"name":"吉村 弘"}]},"event":{"en":"第55回歯科基礎医学会[2013年9月19日(金)-21日(日)]","ja":"第55回歯科基礎医学会[2013年9月19日(金)-21日(日)]"},"publication_date":"2013-09","languages":["jpn"],"location":{"en":"岡山コンベンションセンター/岡山県","ja":"岡山コンベンションセンター/岡山県"},"is_international_presentation":false},"priority":"input_data"}
line:67, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550706"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=281781","label":"url"}],"presentation_title":{"en":"ラット大脳皮質におけるnon-NMDA受容体活動に依存する20Hzオシレーション","ja":"ラット大脳皮質におけるnon-NMDA受容体活動に依存する20Hzオシレーション"},"presenters":{"en":[{"name":"Yoshimura Hiroshi"},{"name":"須貝 外喜夫"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Hasegawa Takahiro"},{"name":"加藤 伸郎"}],"ja":[{"name":"吉村 弘"},{"name":"須貝 外喜夫"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"長谷川 敬展"},{"name":"加藤 伸郎"}]},"event":{"en":"第36回日本神経科学大会[2013年6月20日(木)-23日(日)]","ja":"第36回日本神経科学大会[2013年6月20日(木)-23日(日)]"},"publication_date":"2013-06-20","languages":["jpn"],"location":{"en":"国立京都国際会館/京都府","ja":"国立京都国際会館/京都府"},"is_international_presentation":false},"priority":"input_data"}
line:68, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550707"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=281777","label":"url"}],"presentation_title":{"en":"ヒト唾液腺HSG細胞における構成的なAQP5の取り込み","ja":"ヒト唾液腺HSG細胞における構成的なAQP5の取り込み"},"presenters":{"en":[{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"吉村 弘"}]},"event":{"en":"Journal of Oral Biosciences","ja":"Journal of Oral Biosciences"},"publication_date":"2013","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:69, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550688"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=249260","label":"url"}],"presentation_title":{"en":"唾液腺細胞におけるアクアポリン5の翻訳後修飾","ja":"唾液腺細胞におけるアクアポリン5の翻訳後修飾"},"presenters":{"en":[{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"細井 和雄"}]},"event":{"en":"第53回歯科基礎医学会学術大会 サテライトシンポジウムSS11","ja":"第53回歯科基礎医学会学術大会 サテライトシンポジウムSS11"},"publication_date":"2011-09-30","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:70, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550708"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=249258","label":"url"}],"presentation_title":{"en":"唾液腺細胞におけるアクアポリン5の翻訳後修飾 --- 第53回歯科基礎医学会学術大会(2011年9月30日-10月2日)サテライトシンポジウムSS11","ja":"唾液腺細胞におけるアクアポリン5の翻訳後修飾 --- 第53回歯科基礎医学会学術大会(2011年9月30日-10月2日)サテライトシンポジウムSS11"},"presenters":{"en":[{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"細井 和雄"}]},"event":{"en":"Journal of Oral Biosciences","ja":"Journal of Oral Biosciences"},"publication_date":"2011-09-01","languages":["jpn"],"promoter":{"en":"Japanese Association for Oral Biology","ja":"歯科基礎医学会"},"location":{"en":"Gifu","ja":"岐阜"},"is_international_presentation":false},"priority":"input_data"}
line:71, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550709"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=235256","label":"url"}],"presentation_title":{"en":"Calprotectin expression in the mouse salivary gland: Induction by lipopolysaccharide","ja":"Calprotectin expression in the mouse salivary gland: Induction by lipopolysaccharide"},"presenters":{"en":[{"name":"Javkhlan Purevjav"},{"name":"Hiroshima Yuka"},{"name":"Azlina Ahmad"},{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Nagata Toshihiko"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Javkhlan Purevjav"},{"name":"廣島 佑香"},{"name":"Azlina Ahmad"},{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"永田 俊彦"},{"name":"細井 和雄"}]},"event":{"en":"第52回歯科基礎医学会(2010年9月20-22日)","ja":"第52回歯科基礎医学会(2010年9月20-22日)"},"publication_date":"2010-09-20","languages":["eng"],"location":{"en":"船堀","ja":"船堀"},"is_international_presentation":false},"priority":"input_data"}
line:72, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550710"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=235255","label":"url"}],"presentation_title":{"en":"Porphyromonas gingivalis由来LPSはヒト好中球からのレジスチンの遊離を促進する","ja":"Porphyromonas gingivalis由来LPSはヒト好中球からのレジスチンの遊離を促進する"},"presenters":{"en":[{"name":"Hiroshima Yuka"},{"name":"Javkhlan Purevjav"},{"name":"Azlina Ahmad"},{"name":"Hasegawa Takahiro"},{"name":"Akamatsu Tetsuya"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"廣島 佑香"},{"name":"Javkhlan Purevjav"},{"name":"Azlina Ahmad"},{"name":"長谷川 敬展"},{"name":"赤松 徹也"},{"name":"細井 和雄"}]},"event":{"en":"第52回歯科基礎医学会(2010年9月20-22日)","ja":"第52回歯科基礎医学会(2010年9月20-22日)"},"publication_date":"2010-09-20","languages":["jpn"],"location":{"en":"船堀","ja":"船堀"},"is_international_presentation":false},"priority":"input_data"}
line:73, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550711"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=235254","label":"url"}],"presentation_title":{"en":"唾液腺細胞におけるアクアポリン5リン酸化のシグナル伝達機構","ja":"唾液腺細胞におけるアクアポリン5リン酸化のシグナル伝達機構"},"presenters":{"en":[{"name":"Hasegawa Takahiro"},{"name":"Azlina Ahmad"},{"name":"Javkhlan Purevjav"},{"name":"Hiroshima Yuka"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"長谷川 敬展"},{"name":"Azlina Ahmad"},{"name":"Javkhlan Purevjav"},{"name":"廣島 佑香"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"細井 和雄"}]},"event":{"en":"第52回歯科基礎医学会(2010年9月20-22日)","ja":"第52回歯科基礎医学会(2010年9月20-22日)"},"publication_date":"2010-09-20","languages":["jpn"],"location":{"en":"船堀","ja":"船堀"},"is_international_presentation":false},"priority":"input_data"}
line:74, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550713"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=232260","label":"url"}],"presentation_title":{"en":"Calprotectin expression in the mouse salivary gland: Induction by lipopolysaccharide","ja":"Calprotectin expression in the mouse salivary gland: Induction by lipopolysaccharide"},"presenters":{"en":[{"name":"Javkhlan Purevjav"},{"name":"Hiroshima Yuka"},{"name":"Azlina Ahmad"},{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Nagata Toshihiko"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Javkhlan Purevjav"},{"name":"廣島 佑香"},{"name":"Azlina Ahmad"},{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"永田 俊彦"},{"name":"細井 和雄"}]},"event":{"en":"Journal of Oral Biosciences","ja":"Journal of Oral Biosciences"},"publication_date":"2010-09-10","languages":["eng"],"is_international_presentation":false},"priority":"input_data"}
line:75, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550714"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=232259","label":"url"}],"presentation_title":{"en":"Porphyromonas gingivalis由来LPSはヒト好中球からのレジスチンの遊離を促進する","ja":"Porphyromonas gingivalis由来LPSはヒト好中球からのレジスチンの遊離を促進する"},"presenters":{"en":[{"name":"Hiroshima Yuka"},{"name":"Purevjav Javkhlan"},{"name":"Azlina Ahmad"},{"name":"Hasegawa Takahiro"},{"name":"Akamatsu Tetsuya"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"廣島 佑香"},{"name":"フルジャフ ジャフラン"},{"name":"Azlina Ahmad"},{"name":"長谷川 敬展"},{"name":"赤松 徹也"},{"name":"細井 和雄"}]},"event":{"en":"Journal of Oral Biosciences","ja":"Journal of Oral Biosciences"},"publication_date":"2010-09-10","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:76, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550715"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=232258","label":"url"}],"presentation_title":{"en":"唾液腺細胞におけるアクアポリン5リン酸化のシグナル伝達機構","ja":"唾液腺細胞におけるアクアポリン5リン酸化のシグナル伝達機構"},"presenters":{"en":[{"name":"Hasegawa Takahiro"},{"name":"Azlina Ahmad"},{"name":"Purevjav Javkhlan"},{"name":"Hiroshima Yuka"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"長谷川 敬展"},{"name":"Azlina Ahmad"},{"name":"フルジャフ ジャフラン"},{"name":"廣島 佑香"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"細井 和雄"}]},"event":{"en":"Journal of Oral Biosciences","ja":"Journal of Oral Biosciences"},"publication_date":"2010-09-10","languages":["jpn"],"promoter":{"en":"Japanese Association for Oral Biology","ja":"歯科基礎医学会"},"is_international_presentation":false},"priority":"input_data"}
line:77, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817474"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383122","label":"url"}],"presentation_title":{"en":"NF-κB/AP-1の複合体を介した耳下腺AQP5のLPSによるdown-regulation","ja":"NF-κB/AP-1の複合体を介した耳下腺AQP5のLPSによるdown-regulation"},"presenters":{"en":[{"name":"Yao Chenjuan"},{"name":"Azlina Ahmad"},{"name":"Purevjav Javkhlan"},{"name":"Hasegawa Takahiro"},{"name":"Akamatsu Tetsuya"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"姚 陳娟"},{"name":"Azlina Ahmad"},{"name":"フルジャフ ジャフラン"},{"name":"長谷川 敬展"},{"name":"赤松 徹也"},{"name":"細井 和雄"}]},"event":{"en":"第51回歯科基礎医学会","ja":"第51回歯科基礎医学会"},"publication_date":"2009-09","languages":["jpn"],"location":{"en":"Niigata","ja":"新潟"},"is_international_presentation":false},"priority":"input_data"}
line:78, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817475"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383121","label":"url"}],"presentation_title":{"en":"唾液腺の発生と細胞分化","ja":"唾液腺の発生と細胞分化"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Azlina Ahmad"},{"name":"Purevjav Javkhlan"},{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"赤松 徹也"},{"name":"Azlina Ahmad"},{"name":"フルジャフ ジャフラン"},{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"細井 和雄"}]},"event":{"en":"第51回歯科基礎医学会","ja":"第51回歯科基礎医学会"},"publication_date":"2009-09","languages":["jpn"],"location":{"en":"Niigata","ja":"新潟"},"is_international_presentation":false},"priority":"input_data"}
line:79, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817476"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383120","label":"url"}],"presentation_title":{"en":"アクアポリン5のユビキチン化とその細胞内膜輸送系における役割","ja":"アクアポリン5のユビキチン化とその細胞内膜輸送系における役割"},"presenters":{"en":[{"name":"Hasegawa Takahiro"},{"name":"Azlina Ahmad"},{"name":"Purevjav Javkhlan"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"長谷川 敬展"},{"name":"Azlina Ahmad"},{"name":"フルジャフ ジャフラン"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"細井 和雄"}]},"event":{"en":"第51回歯科基礎医学会","ja":"第51回歯科基礎医学会"},"publication_date":"2009-09","languages":["jpn"],"location":{"en":"Niigata","ja":"新潟"},"is_international_presentation":false},"priority":"input_data"}
line:80, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817477"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383119","label":"url"}],"presentation_title":{"en":"Calprotectin induction by lipopolysaccharide in the salivary gland of mice","ja":"マウス唾液腺でのリポ多糖によるカルプロテクチン誘導"},"presenters":{"en":[{"name":"Purevjav Javkhlan"},{"name":"Hiroshima Yuka"},{"name":"Azlina Ahmad"},{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Nagata Toshihiko"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"フルジャフ ジャフラン"},{"name":"廣島 佑香"},{"name":"Azlina Ahmad"},{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"永田 俊彦"},{"name":"細井 和雄"}]},"event":{"en":"第51回歯科基礎医学会","ja":"第51回歯科基礎医学会"},"publication_date":"2009-09","location":{"en":"Niigata","ja":"新潟"},"is_international_presentation":false},"priority":"input_data"}
line:81, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817478"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383118","label":"url"}],"presentation_title":{"en":"AQP5 degradation via autophagy following parasympathetic denervation in the rat SMG.","ja":"ラット顎下腺での副交感神経切除に続くオートファジーを介したAQP5分解"},"presenters":{"en":[{"name":"Azlina Ahmad"},{"name":"Purevjav Javkhlan"},{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Azlina Ahmad"},{"name":"フルジャフ ジャフラン"},{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"細井 和雄"}]},"event":{"en":"第51回歯科基礎医学会","ja":"第51回歯科基礎医学会"},"publication_date":"2009-09","location":{"en":"Niigata","ja":"新潟"},"is_international_presentation":false},"priority":"input_data"}
line:82, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817479"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383117","label":"url"}],"presentation_title":{"en":"唾液腺発生におけるサチライシン様前駆体蛋白質変換酵素PACE4の生理機能","ja":"唾液腺発生におけるサチライシン様前駆体蛋白質変換酵素PACE4の生理機能"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"}],"ja":[{"name":"赤松 徹也"}]},"event":{"en":"第51回歯科基礎医学会","ja":"第51回歯科基礎医学会"},"publication_date":"2009-09","languages":["jpn"],"location":{"en":"Niigata","ja":"新潟"},"is_international_presentation":false},"priority":"input_data"}
line:83, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817480"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383115","label":"url"}],"presentation_title":{"en":"An AQP5 G103D mutant found in SD rats shows normal water permeability but reduced membrane trafficking","ja":"SDラットで見られるAQP5 G103D変異は正常な水透過性を示すが，膜へのトラフィッキングが低下した"},"presenters":{"en":[{"name":"カラバシル ミレーバ"},{"name":"Hasegawa Takahiro"},{"name":"アズリナ アハマド"},{"name":"プルワンティ ヌヌク"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"カラバシル ミレーバ"},{"name":"長谷川 敬展"},{"name":"アズリナ アハマド"},{"name":"プルワンティ ヌヌク"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"細井 和雄"}]},"event":{"en":"第50回歯科基礎医学会","ja":"第50回歯科基礎医学会"},"publication_date":"2008-09","location":{"en":"Tokyo","ja":"東京"},"is_international_presentation":false},"priority":"input_data"}
line:84, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817481"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383114","label":"url"}],"presentation_title":{"en":"唾液腺AQP5のLPSによるdown-regulationの機構","ja":"唾液腺AQP5のLPSによるdown-regulationの機構"},"presenters":{"en":[{"name":"Yao Chenjuan"},{"name":"アズリナ アハマド"},{"name":"プルワンティ ヌヌク"},{"name":"カラバシル ミレーバ"},{"name":"Hasegawa Takahiro"},{"name":"Akamatsu Tetsuya"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"姚 陳娟"},{"name":"アズリナ アハマド"},{"name":"プルワンティ ヌヌク"},{"name":"カラバシル ミレーバ"},{"name":"長谷川 敬展"},{"name":"赤松 徹也"},{"name":"細井 和雄"}]},"event":{"en":"第50回歯科基礎医学会","ja":"第50回歯科基礎医学会"},"publication_date":"2008-09","languages":["jpn"],"location":{"en":"Tokyo","ja":"東京"},"is_international_presentation":false},"priority":"input_data"}
line:85, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817482"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383113","label":"url"}],"presentation_title":{"en":"Down regulation of submandibular gland AQP5 by chorda tympany denervation","ja":"副交感神経切除による顎下腺AQP5のダウンレギュレーション"},"presenters":{"en":[{"name":"アズリナ アハマド"},{"name":"プルワンティ ヌヌク"},{"name":"カラバシル ミレーバ"},{"name":"Yao Chenjuan"},{"name":"Hasegawa Takahiro"},{"name":"Akamatsu Tetsuya"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"アズリナ アハマド"},{"name":"プルワンティ ヌヌク"},{"name":"カラバシル ミレーバ"},{"name":"姚 陳娟"},{"name":"長谷川 敬展"},{"name":"赤松 徹也"},{"name":"細井 和雄"}]},"event":{"en":"第50回歯科基礎医学会","ja":"第50回歯科基礎医学会"},"publication_date":"2008-09","location":{"en":"Tokyo","ja":"東京"},"is_international_presentation":false},"priority":"input_data"}
line:86, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817483"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383112","label":"url"}],"presentation_title":{"en":"Involvement of IL-6-STAT3-Sca-1 system in the proliferation of duct cells in the ligated mouse submandibular gland","ja":"導管結紮マウス顎下腺における導管細胞の増殖へのIL-6-STAT3-Sca-1系の関与"},"presenters":{"en":[{"name":"プルワンティ ヌヌク"},{"name":"アズリナ アハマド"},{"name":"カラバシル ミレーバ"},{"name":"Yao Chenjuan"},{"name":"Hasegawa Takahiro"},{"name":"Akamatsu Tetsuya"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"プルワンティ ヌヌク"},{"name":"アズリナ アハマド"},{"name":"カラバシル ミレーバ"},{"name":"姚 陳娟"},{"name":"長谷川 敬展"},{"name":"赤松 徹也"},{"name":"細井 和雄"}]},"event":{"en":"第50回歯科基礎医学会","ja":"第50回歯科基礎医学会"},"publication_date":"2008-09","location":{"en":"Tokyo","ja":"東京"},"is_international_presentation":false},"priority":"input_data"}
line:87, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817484"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383108","label":"url"}],"presentation_title":{"en":"LPSによる耳下腺AQP5の発現制御とそのシグナル伝達経路","ja":"LPSによる耳下腺AQP5の発現制御とそのシグナル伝達経路"},"presenters":{"en":[{"name":"Yao Chenjuan"},{"name":"アズリナ アハマド"},{"name":"プルワンティ ヌヌク"},{"name":"カラバシル ミレーバ"},{"name":"Hasegawa Takahiro"},{"name":"Akamatsu Tetsuya"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"姚 陳娟"},{"name":"アズリナ アハマド"},{"name":"プルワンティ ヌヌク"},{"name":"カラバシル ミレーバ"},{"name":"長谷川 敬展"},{"name":"赤松 徹也"},{"name":"細井 和雄"}]},"event":{"en":"第59回日本生理学会中国四国地方会","ja":"第59回日本生理学会中国四国地方会"},"publication_date":"2007-11","languages":["jpn"],"location":{"en":"Tokushima","ja":"徳島"},"is_international_presentation":false},"priority":"input_data"}
line:88, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817485"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383107","label":"url"}],"presentation_title":{"en":"唾液腺腺房細胞の発生・分化・成熟化と水チャネルAQP5発現","ja":"唾液腺腺房細胞の発生・分化・成熟化と水チャネルAQP5発現"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"アズリナ アハマド"},{"name":"プルワンティ ヌヌク"},{"name":"カラバシル ミレーバ"},{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"赤松 徹也"},{"name":"アズリナ アハマド"},{"name":"プルワンティ ヌヌク"},{"name":"カラバシル ミレーバ"},{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"細井 和雄"}]},"event":{"en":"第59回日本生理学会中国四国地方会","ja":"第59回日本生理学会中国四国地方会"},"publication_date":"2007-11","languages":["jpn"],"location":{"en":"Tokushima","ja":"徳島"},"is_international_presentation":false},"priority":"input_data"}
line:89, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550716"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=164637","label":"url"}],"presentation_title":{"en":"Transient increase in IL-6 by duct ligation leading to continuous elevation of Sca-1, a stem cells marker, in the mouse submandibular gland","ja":"導管結紮によるマウス顎下腺での一過性のIL-6の増加が幹細胞マーカーSca-1の持続的な上昇を引き起す"},"presenters":{"en":[{"name":"プルワンティ ヌヌク"},{"name":"Tsuji Daisuke"},{"name":"アズリナ アハマド"},{"name":"カラバシル ミレーバ"},{"name":"Yao Chenjuan"},{"name":"Hasegawa Takahiro"},{"name":"Akamatsu Tetsuya"},{"name":"Itou Kouji"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"プルワンティ ヌヌク"},{"name":"辻 大輔"},{"name":"アズリナ アハマド"},{"name":"カラバシル ミレーバ"},{"name":"姚 陳娟"},{"name":"長谷川 敬展"},{"name":"赤松 徹也"},{"name":"伊藤 孝司"},{"name":"細井 和雄"}]},"event":{"en":"第49回歯科基礎医学会学術大会","ja":"第49回歯科基礎医学会学術大会"},"publication_date":"2007-08-30","location":{"en":"Sapporo","ja":"札幌"},"is_international_presentation":false},"priority":"input_data"}
line:90, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817486"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383106","label":"url"}],"presentation_title":{"en":"Analyses of function of rat mutant AQP5 expressed in MDCK II cells","ja":"MDCK II細胞で発現させたラット変異AQP5の機能解析"},"presenters":{"en":[{"name":"カラバシル ミレーバ"},{"name":"Hasegawa Takahiro"},{"name":"アズリナ アハマド"},{"name":"プルワンティ ヌヌク"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"カラバシル ミレーバ"},{"name":"長谷川 敬展"},{"name":"アズリナ アハマド"},{"name":"プルワンティ ヌヌク"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"細井 和雄"}]},"event":{"en":"第49回歯科基礎医学会","ja":"第49回歯科基礎医学会"},"publication_date":"2007-08","location":{"en":"Sapporo","ja":"札幌"},"is_international_presentation":false},"priority":"input_data"}
line:91, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817487"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383105","label":"url"}],"presentation_title":{"en":"Regulation of submandibular gland AQP5 protein expression by lysosomal system","ja":"リソゾーム系による顎下腺AQP5蛋白質発現の調節"},"presenters":{"en":[{"name":"アズリナ アハマド"},{"name":"カラバシル ミレーバ"},{"name":"プルワンティ ヌヌク"},{"name":"Yao Chenjuan"},{"name":"Hasegawa Takahiro"},{"name":"Akamatsu Tetsuya"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"アズリナ アハマド"},{"name":"カラバシル ミレーバ"},{"name":"プルワンティ ヌヌク"},{"name":"姚 陳娟"},{"name":"長谷川 敬展"},{"name":"赤松 徹也"},{"name":"細井 和雄"}]},"event":{"en":"第49回歯科基礎医学会","ja":"第49回歯科基礎医学会"},"publication_date":"2007-08","location":{"en":"Sapporo","ja":"札幌"},"is_international_presentation":false},"priority":"input_data"}
line:92, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817488"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383104","label":"url"}],"presentation_title":{"en":"唾液腺AQP5およびAQP1発現のLPSによるdown-regulation","ja":"唾液腺AQP5およびAQP1発現のLPSによるdown-regulation"},"presenters":{"en":[{"name":"Yao Chenjuan"},{"name":"アズリナ アハマド"},{"name":"プルワンティ ヌヌク"},{"name":"カラバシル ミレーバ"},{"name":"Hasegawa Takahiro"},{"name":"Akamatsu Tetsuya"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"姚 陳娟"},{"name":"アズリナ アハマド"},{"name":"プルワンティ ヌヌク"},{"name":"カラバシル ミレーバ"},{"name":"長谷川 敬展"},{"name":"赤松 徹也"},{"name":"細井 和雄"}]},"event":{"en":"第49回歯科基礎医学会","ja":"第49回歯科基礎医学会"},"publication_date":"2007-08","languages":["jpn"],"location":{"en":"Sapporo","ja":"札幌"},"is_international_presentation":false},"priority":"input_data"}
line:93, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817489"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383103","label":"url"}],"presentation_title":{"en":"唾液腺腺房細胞の分化とAQP5発現","ja":"唾液腺腺房細胞の分化とAQP5発現"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"アズリナ アハマド"},{"name":"プルワンティ ヌヌク"},{"name":"カラバシル ミレーバ"},{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"赤松 徹也"},{"name":"アズリナ アハマド"},{"name":"プルワンティ ヌヌク"},{"name":"カラバシル ミレーバ"},{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"細井 和雄"}]},"event":{"en":"第49回歯科基礎医学会","ja":"第49回歯科基礎医学会"},"publication_date":"2007-08","languages":["jpn"],"location":{"en":"Sapporo","ja":"札幌"},"is_international_presentation":false},"priority":"input_data"}
line:94, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817490"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383092","label":"url"}],"presentation_title":{"en":"Functional analyses of rat mutant AQP5 expressed in vitro system and it's implication to abnormal saliva secretion","ja":"in vitroシステムで発現したラット変異AQP5の機能解析と異常唾液分泌への影響"},"presenters":{"en":[{"name":"カラバシル ミレーバ"},{"name":"Hasegawa Takahiro"},{"name":"プルワンティ ヌヌク"},{"name":"Li Xuefei"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"カラバシル ミレーバ"},{"name":"長谷川 敬展"},{"name":"プルワンティ ヌヌク"},{"name":"李 雪飛"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"第48回歯科基礎医学会","ja":"第48回歯科基礎医学会"},"publication_date":"2006-09","is_international_presentation":false},"priority":"input_data"}
line:95, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817491"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383091","label":"url"}],"presentation_title":{"en":"ラット唾液腺AQP5，AQP1，及びリソゾーム酵素系に対する自律神経切除とSNI2011投与の影響","ja":"ラット唾液腺AQP5，AQP1，及びリソゾーム酵素系に対する自律神経切除とSNI2011投与の影響"},"presenters":{"en":[{"name":"Li Xuefei"},{"name":"Purwanti Nunuk"},{"name":"Karabasil R. Mileva"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"李 雪飛"},{"name":"プルワンティ ヌヌク"},{"name":"カラバシル ミレーバ"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"第48回歯科基礎医学会","ja":"第48回歯科基礎医学会"},"publication_date":"2006-09","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:96, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817492"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383090","label":"url"}],"presentation_title":{"en":"LPSによる唾液腺AQP5およびAQP1の発現制御とそのシグナル伝達経路","ja":"LPSによる唾液腺AQP5およびAQP1の発現制御とそのシグナル伝達経路"},"presenters":{"en":[{"name":"Yao Chenjuan"},{"name":"Karabasil R. Mileva"},{"name":"Purwanti Nunuk"},{"name":"Li Xuefei"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"姚 陳娟"},{"name":"カラバシル ミレーバ"},{"name":"プルワンティ ヌヌク"},{"name":"李 雪飛"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"第48回歯科基礎医学会","ja":"第48回歯科基礎医学会"},"publication_date":"2006-09","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:97, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817493"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383089","label":"url"}],"presentation_title":{"en":"顎下腺の分枝形成とAQP5発現は前駆体蛋白質変換酵素PACE4により調節される","ja":"顎下腺の分枝形成とAQP5発現は前駆体蛋白質変換酵素PACE4により調節される"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Purwanti Nunuk"},{"name":"Karabasil R. Mileva"},{"name":"Li Xuefei"},{"name":"Yao Chenjuan"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"赤松 徹也"},{"name":"プルワンティ ヌヌク"},{"name":"カラバシル ミレーバ"},{"name":"李 雪飛"},{"name":"姚 陳娟"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"第48回歯科基礎医学会","ja":"第48回歯科基礎医学会"},"publication_date":"2006-09","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:98, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550717"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=161679","label":"url"}],"presentation_title":{"en":"Effect of duct ligation on the expression of cellular markers of duct/acini and side population dynamics of the mouse submandibular gland","ja":"マウス顎下腺における腺房細胞/導管細胞マーカーの発現，およびサイドポピュレーション細胞群の挙動に及ぼす主導管結紮の影響"},"presenters":{"en":[{"name":"プルワンティ ヌヌク"},{"name":"Tsuji Daisuke"},{"name":"カラバシル ミレーバ"},{"name":"Li Xuefei"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Itou Kouji"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"プルワンティ ヌヌク"},{"name":"辻 大輔"},{"name":"カラバシル ミレーバ"},{"name":"李 雪飛"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"伊藤 孝司"},{"name":"細井 和雄"}]},"event":{"en":"第48回歯科基礎医学会学術大会","ja":"第48回歯科基礎医学会学術大会"},"publication_date":"2006-09","is_international_presentation":false},"priority":"input_data"}
line:99, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817494"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383085","label":"url"}],"presentation_title":{"en":"唾液腺発生におけるsubtilisin-like proprotein convertaseの役割","ja":"唾液腺発生におけるsubtilisin-like proprotein convertaseの役割"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"プルワンティ ヌヌク"},{"name":"カラバシル ミレーバ"},{"name":"Li Xuefei"},{"name":"Yao Chenjuan"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"赤松 徹也"},{"name":"プルワンティ ヌヌク"},{"name":"カラバシル ミレーバ"},{"name":"李 雪飛"},{"name":"姚 陳娟"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"第28回分子生物学会年会, ワークショップW3G「プロテアーゼによる細胞分化・機能制御, 植物から動物まで/Proteases as biomodulators in bacteria, plant and animal」","ja":"第28回分子生物学会年会, ワークショップW3G「プロテアーゼによる細胞分化・機能制御, 植物から動物まで/Proteases as biomodulators in bacteria, plant and animal」"},"publication_date":"2005-12","languages":["jpn"],"location":{"en":"Fukuoka","ja":"福岡"},"is_international_presentation":false},"priority":"input_data"}
line:100, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817495"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383084","label":"url"}],"presentation_title":{"en":"Effects of sympathectomy, parasympathectomy, administration of SNI-2011 on the expression of AQP5 and AQP1 in the rat submandibular gland","ja":"交感神経切除，副交感神経切除，およびSNI-2011投与のラット顎下腺におけるAQP5，AQP1発現におよぼす影響"},"presenters":{"en":[{"name":"Li Xuefei"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"李 雪飛"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"第78回日本生化学会大会","ja":"第78回日本生化学会大会"},"publication_date":"2005-10","is_international_presentation":false},"priority":"input_data"}
line:101, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817496"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383083","label":"url"}],"presentation_title":{"en":"Kallikrein mK13 is a candidate of pro-IL-1βprocessing enzyme in the mouse salivary gland","ja":"カリクレインmK13はマウス唾液腺におけるpro-IL-1βプロセシング酵素の候補である"},"presenters":{"en":[{"name":"Yao Chenjuan"},{"name":"Purwanti Nunuk"},{"name":"Kosugi-Tanaka Chisato"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"姚 陳娟"},{"name":"Purwanti Nunuk"},{"name":"Kosugi-Tanaka Chisato"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"第78回日本生化学会大会","ja":"第78回日本生化学会大会"},"publication_date":"2005-10","is_international_presentation":false},"priority":"input_data"}
line:102, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817497"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383082","label":"url"}],"presentation_title":{"en":"Developmental regulation of the submandibular gland by ECM-bound proprotein convertase PACE4","ja":"ECM結合型前駆体蛋白質変換酵素PACE4による顎下腺発生過程の調節"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Purwanti Nunuk"},{"name":"Li Xuefei"},{"name":"Yao Chenjuan"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"赤松 徹也"},{"name":"Purwanti Nunuk"},{"name":"李 雪飛"},{"name":"姚 陳娟"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"第78回日本生化学会大会","ja":"第78回日本生化学会大会"},"publication_date":"2005-10","is_international_presentation":false},"priority":"input_data"}
line:103, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817498"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383081","label":"url"}],"presentation_title":{"en":"ラット顎下腺AQP5並びにAQP1に対する交感神経切除・副交感神経切除及びSNI-2011投与の影響","ja":"ラット顎下腺AQP5並びにAQP1に対する交感神経切除・副交感神経切除及びSNI-2011投与の影響"},"presenters":{"en":[{"name":"Li Xuefei"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"李 雪飛"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"第47回歯科基礎医学会","ja":"第47回歯科基礎医学会"},"publication_date":"2005-09","languages":["jpn"],"location":{"en":"Sendai","ja":"仙台"},"is_international_presentation":false},"priority":"input_data"}
line:104, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817499"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383080","label":"url"}],"presentation_title":{"en":"マウス唾液腺カリクレインmK13はpro-IL-1βプロセシング酵素の候補である","ja":"マウス唾液腺カリクレインmK13はpro-IL-1βプロセシング酵素の候補である"},"presenters":{"en":[{"name":"Yao Chenjuan"},{"name":"Li Xuefei"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"姚 陳娟"},{"name":"李 雪飛"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"第47回歯科基礎医学会","ja":"第47回歯科基礎医学会"},"publication_date":"2005-09","languages":["jpn"],"location":{"en":"Sendai","ja":"仙台"},"is_international_presentation":false},"priority":"input_data"}
line:105, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817500"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383079","label":"url"}],"presentation_title":{"en":"顎下腺発生における前駆体蛋白質変換酵素PACE4の関与","ja":"顎下腺発生における前駆体蛋白質変換酵素PACE4の関与"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Li Xuefei"},{"name":"Yao Chenjuan"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"赤松 徹也"},{"name":"李 雪飛"},{"name":"姚 陳娟"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"第47回歯科基礎医学会","ja":"第47回歯科基礎医学会"},"publication_date":"2005-09","languages":["jpn"],"location":{"en":"Sendai","ja":"仙台"},"is_international_presentation":false},"priority":"input_data"}
line:106, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817501"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383078","label":"url"}],"presentation_title":{"en":"外分泌腺における水チャネル，アクアポリンの発現と機能調節","ja":"外分泌腺における水チャネル，アクアポリンの発現と機能調節"},"presenters":{"en":[{"name":"Hosoi Kazuo"},{"name":"Li Xuefei"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"ミレーバ カラバシル"},{"name":"ヌヌク プルワンティ"}],"ja":[{"name":"細井 和雄"},{"name":"李 雪飛"},{"name":"姚 陳娟"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"ミレーバ カラバシル"},{"name":"ヌヌク プルワンティ"}]},"event":{"en":"第47回歯科基礎医学会サテライトシンポジウム「唾液分泌機構研究の最近の進歩」","ja":"第47回歯科基礎医学会サテライトシンポジウム「唾液分泌機構研究の最近の進歩」"},"publication_date":"2005-09","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:107, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817502"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383074","label":"url"}],"presentation_title":{"en":"ECM-bound proprotein convertase PACE4 is a candidate regulator in the branching morphogenesis of rat submandibular gland","ja":"ECM結合型前駆体蛋白質変換酵素PACE4はラット顎下腺の分枝形成における調節因子候補である"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Li Xuefei"},{"name":"Yao Chenjuan"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"赤松 徹也"},{"name":"李 雪飛"},{"name":"姚 陳娟"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"第77回日本生化学会大会","ja":"第77回日本生化学会大会"},"publication_date":"2004-10","location":{"en":"Yokohama","ja":"横浜"},"is_international_presentation":false},"priority":"input_data"}
line:108, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817503"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383073","label":"url"}],"presentation_title":{"en":"マウス顎下腺におけるカリクレインmK13によるpro-IL1βの活性化","ja":"マウス顎下腺におけるカリクレインmK13によるpro-IL1βの活性化"},"presenters":{"en":[{"name":"Yao Chenjuan"},{"name":"Li Xuefei"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"姚 陳娟"},{"name":"李 雪飛"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"第46回歯科基礎医学会","ja":"第46回歯科基礎医学会"},"publication_date":"2004-09","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:109, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817504"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383072","label":"url"}],"presentation_title":{"en":"顎下腺の分枝形成と機能発現","ja":"顎下腺の分枝形成と機能発現"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Li Xuefei"},{"name":"Yao Chenjuan"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"赤松 徹也"},{"name":"李 雪飛"},{"name":"姚 陳娟"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"第46回歯科基礎医学会","ja":"第46回歯科基礎医学会"},"publication_date":"2004-09","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:110, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817505"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383071","label":"url"}],"presentation_title":{"en":"ラット顎下腺発生過程での水チャネルAQPファミリーの発現と局在","ja":"ラット顎下腺発生過程での水チャネルAQPファミリーの発現と局在"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"}],"ja":[{"name":"赤松 徹也"}]},"event":{"en":"第28回四国歯学会/第9回高田充歯科基礎医学奨励賞受賞講演","ja":"第28回四国歯学会/第9回高田充歯科基礎医学奨励賞受賞講演"},"publication_date":"2004-06","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:111, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817506"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383070","label":"url"}],"presentation_title":{"en":"水チャネル，アクアポリンの外分泌腺における発現と機能調節","ja":"水チャネル，アクアポリンの外分泌腺における発現と機能調節"},"presenters":{"en":[{"name":"Murdiastuti Kawartarini"},{"name":"Parvin Nahid"},{"name":"Yao Chenjuan"},{"name":"Li Xuefei"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Murdiastuti Kawartarini"},{"name":"Parvin Nahid"},{"name":"姚 陳娟"},{"name":"李 雪飛"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"第45回日本生化学会中国・四国支部例会","ja":"第45回日本生化学会中国・四国支部例会"},"publication_date":"2004-05","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:112, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817507"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383069","label":"url"}],"presentation_title":{"en":"ラット顎下腺の発生・分化・成熟と機能発現","ja":"ラット顎下腺の発生・分化・成熟と機能発現"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Li Xuefei"},{"name":"Yao Chenjuan"},{"name":"Murdiastuti Kawartarini"},{"name":"Kosugi Chisato"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"赤松 徹也"},{"name":"李 雪飛"},{"name":"姚 陳娟"},{"name":"Murdiastuti Kawartarini"},{"name":"小杉 知里"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"第45回日本生化学会中国・四国支部例会","ja":"第45回日本生化学会中国・四国支部例会"},"publication_date":"2004-05","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:113, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817508"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383067","label":"url"}],"presentation_title":{"en":"実験的炎症による唾液腺サイトカインの誘導","ja":"実験的炎症による唾液腺サイトカインの誘導"},"presenters":{"en":[{"name":"Yao Chenjuan"},{"name":"Li Xuefei"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"姚 陳娟"},{"name":"李 雪飛"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"第45回歯科基礎医学会","ja":"第45回歯科基礎医学会"},"publication_date":"2003-09","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:114, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817509"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383066","label":"url"}],"presentation_title":{"en":"Jumping: An index behavior for the epileptic family of Mongolian gerbil. (Preliminary report)","ja":"ジャンピング:てんかん家系スナネズミに対する行動指標(プレリミナリーレポート)"},"presenters":{"en":[{"name":"Kanamori Norio"},{"name":"Akamatsu Tetsuya"},{"name":"Kosugi Chisato"},{"name":"Murdiastuti Kawartarini"},{"name":"Parvin Nahid Most."},{"name":"Yao Chenjuan"},{"name":"Miki Osamu"},{"name":"Li Xuefei"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"金森 憲雄"},{"name":"赤松 徹也"},{"name":"Kosugi Chisato"},{"name":"Murdiastuti Kawartarini"},{"name":"Parvin Nahid Most."},{"name":"姚 陳娟"},{"name":"Miki Osamu"},{"name":"Li Xuefei"},{"name":"細井 和雄"}]},"event":{"en":"第26回日本神経科学大会","ja":"第26回日本神経科学大会"},"publication_date":"2003-07","is_international_presentation":false},"priority":"input_data"}
line:115, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817510"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383065","label":"url"}],"presentation_title":{"en":"ラット顎下腺発生過程でのAQPsの発現と局在","ja":"ラット顎下腺発生過程でのAQPsの発現と局在"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Parvin Nahid Most."},{"name":"小杉-田中 知里"},{"name":"Yao Chenjuan"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"赤松 徹也"},{"name":"Parvin Nahid Most."},{"name":"小杉-田中 知里"},{"name":"姚 陳娟"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"第75回日本生化学会大会","ja":"第75回日本生化学会大会"},"publication_date":"2002-10","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:116, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817511"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383064","label":"url"}],"presentation_title":{"en":"Divergent gene expression and localization of aquaporin 5 in the submandibular gland of Sprague-Dawley rats","ja":"Sprague-Dawleyラット顎下腺におけるAQP5の相違する遺伝子発現と局在"},"presenters":{"en":[{"name":"Murdiastuti Kawartarini"},{"name":"三木 修"},{"name":"Yao Chenjuan"},{"name":"Parvin Nahid Most."},{"name":"小杉-田中 知里"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Murdiastuti Kawartarini"},{"name":"三木 修"},{"name":"姚 陳娟"},{"name":"Parvin Nahid Most."},{"name":"小杉-田中 知里"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"第44回歯科基礎医学会","ja":"第44回歯科基礎医学会"},"publication_date":"2002-10","is_international_presentation":false},"priority":"input_data"}
line:117, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817512"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383063","label":"url"}],"presentation_title":{"en":"ラット顎下腺発生過程でのAQPsの発現と局在","ja":"ラット顎下腺発生過程でのAQPsの発現と局在"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Parvin Nahid Most."},{"name":"小杉-田中 知里"},{"name":"Yao Chenjuan"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"赤松 徹也"},{"name":"Parvin Nahid Most."},{"name":"小杉-田中 知里"},{"name":"姚 陳娟"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"第44回歯科基礎医学会","ja":"第44回歯科基礎医学会"},"publication_date":"2002-10","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:118, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817513"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383062","label":"url"}],"presentation_title":{"en":"病態モデルスナネズミ近交化の試み(中間報告)","ja":"病態モデルスナネズミ近交化の試み(中間報告)"},"presenters":{"en":[{"name":"Kanamori Norio"},{"name":"Akamatsu Tetsuya"},{"name":"小杉-田中 知里"},{"name":"Parvin Nahid Most."},{"name":"Yao Chenjuan"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"金森 憲雄"},{"name":"赤松 徹也"},{"name":"小杉-田中 知里"},{"name":"Parvin Nahid Most."},{"name":"姚 陳娟"},{"name":"細井 和雄"}]},"event":{"en":"第25回日本神経科学大会","ja":"第25回日本神経科学大会"},"publication_date":"2002-07","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:119, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817514"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383061","label":"url"}],"presentation_title":{"en":"AQP5 in the rat duodenum-expression, localization, and effect of VIP","ja":"AQP5のラット十二指腸での発現，局在，およびVIPの効果"},"presenters":{"en":[{"name":"Nahid Parvin Most."},{"name":"小杉-田中 知里"},{"name":"Akamatsu Tetsuya"},{"name":"倉淵 真悟"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Nahid Parvin Most."},{"name":"小杉-田中 知里"},{"name":"赤松 徹也"},{"name":"倉淵 真悟"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"第79回日本生理学会学術大会","ja":"第79回日本生理学会学術大会"},"publication_date":"2002-03","is_international_presentation":false},"priority":"input_data"}
line:120, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817515"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383060","label":"url"}],"presentation_title":{"en":"水代謝異常多飲多渇マウス(STR/N)の唾液腺および腎におけるアクアポリン(AQP)の発現","ja":"水代謝異常多飲多渇マウス(STR/N)の唾液腺および腎におけるアクアポリン(AQP)の発現"},"presenters":{"en":[{"name":"津村 恵子"},{"name":"Nahid Parvin Most."},{"name":"Murdiastuti Kawartarini"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"稲永 清敏"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"津村 恵子"},{"name":"Nahid Parvin Most."},{"name":"Murdiastuti Kawartarini"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"稲永 清敏"},{"name":"細井 和雄"}]},"event":{"en":"第43回歯科基礎医学会学術大会","ja":"第43回歯科基礎医学会学術大会"},"publication_date":"2001-09","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:121, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817516"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383059","label":"url"}],"presentation_title":{"en":"ラット唾液線発生過程でのAQPsの発現","ja":"ラット唾液線発生過程でのAQPsの発現"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Nahid Parvin Most"},{"name":"Murdiastuti Kawartarini"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"赤松 徹也"},{"name":"Nahid Parvin Most"},{"name":"Murdiastuti Kawartarini"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"第43回歯科基礎医学会学術大会","ja":"第43回歯科基礎医学会学術大会"},"publication_date":"2001-09","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:122, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817517"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383058","label":"url"}],"presentation_title":{"en":"Expression of AQP5 in the duodenum Brunner's gland and effects of VIP","ja":"十二指腸ブルナー腺におけるAQP5発現とVIPの効果"},"presenters":{"en":[{"name":"Nahid Parvin Most"},{"name":"Murdiastuti Kawartarini"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Nahid Parvin Most"},{"name":"Murdiastuti Kawartarini"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"第43回歯科基礎医学会学術大会","ja":"第43回歯科基礎医学会学術大会"},"publication_date":"2001-09","is_international_presentation":false},"priority":"input_data"}
line:123, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817518"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383057","label":"url"}],"presentation_title":{"en":"口腔組織発生におけるプロセシング酵素PACE4の役割","ja":"口腔組織発生におけるプロセシング酵素PACE4の役割"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"津村 恵子"},{"name":"多田 淳"},{"name":"Parvin Nahid Most."},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"赤松 徹也"},{"name":"津村 恵子"},{"name":"多田 淳"},{"name":"Parvin Nahid Most."},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"日本生化学会第73回大会","ja":"日本生化学会第73回大会"},"publication_date":"2000-10","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:124, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817519"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383056","label":"url"}],"presentation_title":{"en":"Induction of acute phase proteins in the salivary gland of rats","ja":"ラット唾液腺における急性期蛋白質の誘導"},"presenters":{"en":[{"name":"Wei Wei"},{"name":"Parvin Nahid Most."},{"name":"津村 恵子"},{"name":"松浦 幸子"},{"name":"Akamatsu Tetsuya"},{"name":"多田 淳"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Wei Wei"},{"name":"Parvin Nahid Most."},{"name":"津村 恵子"},{"name":"松浦 幸子"},{"name":"赤松 徹也"},{"name":"多田 淳"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"第42回歯科基礎医学会学術大会","ja":"第42回歯科基礎医学会学術大会"},"publication_date":"2000-09","is_international_presentation":false},"priority":"input_data"}
line:125, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817520"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383055","label":"url"}],"presentation_title":{"en":"唾液腺培養細胞でのAQP5のトラフィッキング機構","ja":"唾液腺培養細胞でのAQP5のトラフィッキング機構"},"presenters":{"en":[{"name":"多田 淳"},{"name":"津村 恵子"},{"name":"Akamatsu Tetsuya"},{"name":"Parvin Nahid Most."},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"多田 淳"},{"name":"津村 恵子"},{"name":"赤松 徹也"},{"name":"Parvin Nahid Most."},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"第42回歯科基礎医学会学術大会","ja":"第42回歯科基礎医学会学術大会"},"publication_date":"2000-09","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:126, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817521"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383054","label":"url"}],"presentation_title":{"en":"Aquaporin-5 water channel expression and localization in the rat salivary gland and gastrointestinal tract","ja":"ラット唾液腺と消化管におけるアクアポリン-5水チャネル発現と局在"},"presenters":{"en":[{"name":"Parvin Nahid Most."},{"name":"Wei Wei"},{"name":"津村 恵子"},{"name":"多田 淳"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"Parvin Nahid Most."},{"name":"Wei Wei"},{"name":"津村 恵子"},{"name":"多田 淳"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"第42回歯科基礎医学会学術大会","ja":"第42回歯科基礎医学会学術大会"},"publication_date":"2000-09","is_international_presentation":false},"priority":"input_data"}
line:127, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817522"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383053","label":"url"}],"presentation_title":{"en":"歯牙形成における前駆体蛋白質活性化酵素SPCsの役割","ja":"歯牙形成における前駆体蛋白質活性化酵素SPCsの役割"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"松田 佳子"},{"name":"多田 淳"},{"name":"津村 恵子"},{"name":"Parvin Nahid Most."},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"赤松 徹也"},{"name":"松田 佳子"},{"name":"多田 淳"},{"name":"津村 恵子"},{"name":"Parvin Nahid Most."},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"日本生化学会第72回大会","ja":"日本生化学会第72回大会"},"publication_date":"1999-10","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:128, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817523"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383052","label":"url"}],"presentation_title":{"en":"口腔粘膜・肥満細胞でのキニノーゲンの発現","ja":"口腔粘膜・肥満細胞でのキニノーゲンの発現"},"presenters":{"en":[{"name":"松浦 幸子"},{"name":"鈴木 和夫"},{"name":"Akamatsu Tetsuya"},{"name":"津村 恵子"},{"name":"多田 淳"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"松浦 幸子"},{"name":"鈴木 和夫"},{"name":"赤松 徹也"},{"name":"津村 恵子"},{"name":"多田 淳"},{"name":"細井 和雄"}]},"event":{"en":"第41回歯科基礎医学会学術大会","ja":"第41回歯科基礎医学会学術大会"},"publication_date":"1999-09","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:129, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817524"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383051","label":"url"}],"presentation_title":{"en":"前駆体蛋白質活性化酵素SPCのラット唾液腺発生過程での発現","ja":"前駆体蛋白質活性化酵素SPCのラット唾液腺発生過程での発現"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"津村 恵子"},{"name":"Kanamori Norio"},{"name":"多田 淳"},{"name":"Parvin Nahid Most."},{"name":"Hosoi Kazuo"}],"ja":[{"name":"赤松 徹也"},{"name":"津村 恵子"},{"name":"金森 憲雄"},{"name":"多田 淳"},{"name":"Parvin Nahid Most."},{"name":"細井 和雄"}]},"event":{"en":"第41回歯科基礎医学会学術大会","ja":"第41回歯科基礎医学会学術大会"},"publication_date":"1999-09","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:130, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817525"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383050","label":"url"}],"presentation_title":{"en":"スナネズミ総頚動脈結紮時の脳血流動態","ja":"スナネズミ総頚動脈結紮時の脳血流動態"},"presenters":{"en":[{"name":"Kanamori Norio"},{"name":"Satomura Kazuhito"},{"name":"Akamatsu Tetsuya"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"金森 憲雄"},{"name":"里村 一人"},{"name":"赤松 徹也"},{"name":"細井 和雄"}]},"event":{"en":"第22回日本神経科学大会","ja":"第22回日本神経科学大会"},"publication_date":"1999-07","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:131, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817526"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383049","label":"url"}],"presentation_title":{"en":"Subtilisin-like proprotein convertase PACE4 is a candidate processing protease of bone morphogenetic proteins during tooth formation","ja":"サチライシン様前駆体蛋白質変換酵素PACE4は歯の形成過程における骨形成蛋白質のプロセシングプロテアーゼの候補である"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"松田 佳子"},{"name":"辻 明彦"},{"name":"津村 恵子"},{"name":"Kanamori Norio"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"赤松 徹也"},{"name":"松田 佳子"},{"name":"辻 明彦"},{"name":"津村 恵子"},{"name":"金森 憲雄"},{"name":"細井 和雄"}]},"event":{"en":"6th CGGH Symposium","ja":"第6回日本生化学会春期シンポジウム"},"publication_date":"1999-05","is_international_presentation":false},"priority":"input_data"}
line:132, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817527"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383047","label":"url"}],"presentation_title":{"en":"浸潤唾液腺肥満細胞におけるキニノーゲンの発現","ja":"浸潤唾液腺肥満細胞におけるキニノーゲンの発現"},"presenters":{"en":[{"name":"Hosoi Kazuo"},{"name":"津村 恵子"},{"name":"多田 淳"},{"name":"Akamatsu Tetsuya"},{"name":"Kanamori Norio"},{"name":"松浦 幸子"}],"ja":[{"name":"細井 和雄"},{"name":"津村 恵子"},{"name":"多田 淳"},{"name":"赤松 徹也"},{"name":"金森 憲雄"},{"name":"松浦 幸子"}]},"event":{"en":"第40回歯科基礎医学会学術大会","ja":"第40回歯科基礎医学会学術大会"},"publication_date":"1998-10","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:133, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817528"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383046","label":"url"}],"presentation_title":{"en":"エンドセリン-1(1-31)を産生する細胞の同定","ja":"エンドセリン-1(1-31)を産生する細胞の同定"},"presenters":{"en":[{"name":"丹羽 保晴"},{"name":"李 志遠"},{"name":"岡 真紀子"},{"name":"永田 典子"},{"name":"坂本 貞一"},{"name":"大中 正治"},{"name":"Akamatsu Tetsuya"},{"name":"中屋 豊"}],"ja":[{"name":"丹羽 保晴"},{"name":"李 志遠"},{"name":"岡 真紀子"},{"name":"永田 典子"},{"name":"坂本 貞一"},{"name":"大中 正治"},{"name":"赤松 徹也"},{"name":"中屋 豊"}]},"event":{"en":"日本生化学会第71回大会","ja":"日本生化学会第71回大会"},"publication_date":"1998-10","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:134, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817529"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383045","label":"url"}],"presentation_title":{"en":"新たに開発した血管染色法と, それによって判定したスナネズミ大脳動脈輪欠損出現率の系統差","ja":"新たに開発した血管染色法と, それによって判定したスナネズミ大脳動脈輪欠損出現率の系統差"},"presenters":{"en":[{"name":"Kanamori Norio"},{"name":"Akamatsu Tetsuya"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"金森 憲雄"},{"name":"赤松 徹也"},{"name":"細井 和雄"}]},"event":{"en":"第21回日本神経科学・第41回日本神経化学合同大会","ja":"第21回日本神経科学・第41回日本神経化学合同大会"},"publication_date":"1998-09","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:135, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817530"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383044","label":"url"}],"presentation_title":{"en":"ラット脳発生過程でのプロセシング酵素PACE4の発現","ja":"ラット脳発生過程でのプロセシング酵素PACE4の発現"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"吉田 茂"},{"name":"Nagamune Hideaki"},{"name":"Tsuji Akihiko"},{"name":"Matsuda Yoshiko"}],"ja":[{"name":"赤松 徹也"},{"name":"吉田 茂"},{"name":"長宗 秀明"},{"name":"辻 明彦"},{"name":"松田 佳子"}]},"event":{"en":"日本生化学会第70回大会","ja":"日本生化学会第70回大会"},"publication_date":"1997-09","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:136, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817531"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383042","label":"url"}],"presentation_title":{"en":"プロセシング酵素PACE4Eのラット脳発生過程での発現","ja":"プロセシング酵素PACE4Eのラット脳発生過程での発現"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"吉田 茂"},{"name":"大黒 成夫"},{"name":"Nagamune Hideaki"},{"name":"長濱 正巳"},{"name":"Tsuji Akihiko"},{"name":"Matsuda Yoshiko"}],"ja":[{"name":"赤松 徹也"},{"name":"吉田 茂"},{"name":"大黒 成夫"},{"name":"長宗 秀明"},{"name":"長濱 正巳"},{"name":"辻 明彦"},{"name":"松田 佳子"}]},"event":{"en":"日本生化学会第69回大会・日本分子生物学会第19回年会合同年会","ja":"日本生化学会第69回大会・日本分子生物学会第19回年会合同年会"},"publication_date":"1996-08","languages":["jpn"],"location":{"en":"Tokushima","ja":"徳島"},"is_international_presentation":false},"priority":"input_data"}
line:137, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817532"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383040","label":"url"}],"presentation_title":{"en":"Kexin様プロテアーゼPC7の中枢神経系における細胞特異的発現","ja":"Kexin様プロテアーゼPC7の中枢神経系における細胞特異的発現"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"吉田 茂"},{"name":"水野 勝弘"},{"name":"長田 香弥"},{"name":"米本 佳余子"},{"name":"森 健二"},{"name":"Nagamune Hideaki"},{"name":"Tsuji Akihiko"},{"name":"Grouzmann Eric"},{"name":"Matsuda Yoshiko"}],"ja":[{"name":"赤松 徹也"},{"name":"吉田 茂"},{"name":"水野 勝弘"},{"name":"長田 香弥"},{"name":"米本 佳余子"},{"name":"森 健二"},{"name":"長宗 秀明"},{"name":"辻 明彦"},{"name":"Grouzmann Eric"},{"name":"松田 佳子"}]},"event":{"en":"日本生化学会第68回大会","ja":"日本生化学会第68回大会"},"publication_date":"1995-09","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:138, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817533"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383039","label":"url"}],"presentation_title":{"en":"新Kexin様プロテアーゼの構造と組織分布","ja":"新Kexin様プロテアーゼの構造と組織分布"},"presenters":{"en":[{"name":"Tsuji Akihiko"},{"name":"Nagamune Hideaki"},{"name":"Akamatsu Tetsuya"},{"name":"日根 智恵美"},{"name":"村松 和明"},{"name":"森 健二"},{"name":"玉井 靖啓"},{"name":"米本 佳余子"},{"name":"Matsuda Yoshiko"}],"ja":[{"name":"辻 明彦"},{"name":"長宗 秀明"},{"name":"赤松 徹也"},{"name":"日根 智恵美"},{"name":"村松 和明"},{"name":"森 健二"},{"name":"玉井 靖啓"},{"name":"米本 佳余子"},{"name":"松田 佳子"}]},"event":{"en":"日本先天代謝異常学会第36回大会","ja":"日本先天代謝異常学会第36回大会"},"publication_date":"1994-11","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:139, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817534"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383038","label":"url"}],"presentation_title":{"en":"新しいkexinファミリープロテアーゼPC7の細胞特異的発現-in situ hybridizationによる解析","ja":"新しいkexinファミリープロテアーゼPC7の細胞特異的発現-in situ hybridizationによる解析"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"今村 恵美"},{"name":"Nagamune Hideaki"},{"name":"Tsuji Akihiko"},{"name":"Matsuda Yoshiko"}],"ja":[{"name":"赤松 徹也"},{"name":"今村 恵美"},{"name":"長宗 秀明"},{"name":"辻 明彦"},{"name":"松田 佳子"}]},"event":{"en":"日本細胞生物学会第47回大会","ja":"日本細胞生物学会第47回大会"},"publication_date":"1994-09","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:140, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817535"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383037","label":"url"}],"presentation_title":{"en":"新ペプチドホルモンプロセッシングプロテアーゼPACE4Cの細胞特異的発現","ja":"新ペプチドホルモンプロセッシングプロテアーゼPACE4Cの細胞特異的発現"},"presenters":{"en":[{"name":"玉井 靖啓"},{"name":"村松 和明"},{"name":"Akamatsu Tetsuya"},{"name":"日根 智恵美"},{"name":"森 健二"},{"name":"Nagamune Hideaki"},{"name":"Tsuji Akihiko"},{"name":"Izumi Keisuke"},{"name":"Matsuda Yoshiko"}],"ja":[{"name":"玉井 靖啓"},{"name":"村松 和明"},{"name":"赤松 徹也"},{"name":"日根 智恵美"},{"name":"森 健二"},{"name":"長宗 秀明"},{"name":"辻 明彦"},{"name":"泉 啓介"},{"name":"松田 佳子"}]},"event":{"en":"日本細胞生物学会第47回大会","ja":"日本細胞生物学会第47回大会"},"publication_date":"1994-09","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:141, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817536"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383036","label":"url"}],"presentation_title":{"en":"甲状腺傍濾胞細胞におけるサチラーゼファミリープロテアーゼの発現","ja":"甲状腺傍濾胞細胞におけるサチラーゼファミリープロテアーゼの発現"},"presenters":{"en":[{"name":"Nagamune Hideaki"},{"name":"Tsuji Akihiko"},{"name":"村松 和明"},{"name":"Akamatsu Tetsuya"},{"name":"東根 一也"},{"name":"日根 智恵美"},{"name":"Izumi Keisuke"},{"name":"坂口 剛正"},{"name":"吉田 哲也"},{"name":"Noji Sumihare"},{"name":"Matsuda Yoshiko"}],"ja":[{"name":"長宗 秀明"},{"name":"辻 明彦"},{"name":"村松 和明"},{"name":"赤松 徹也"},{"name":"東根 一也"},{"name":"日根 智恵美"},{"name":"泉 啓介"},{"name":"坂口 剛正"},{"name":"吉田 哲也"},{"name":"野地 澄晴"},{"name":"松田 佳子"}]},"event":{"en":"日本生化学会第66回大会","ja":"日本生化学会第66回大会"},"publication_date":"1993-10","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:142, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817537"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383035","label":"url"}],"presentation_title":{"en":"ラット肝α-マクログロブリン-プロテアーゼ複合体の性質","ja":"ラット肝α-マクログロブリン-プロテアーゼ複合体の性質"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Tsuji Akihiko"},{"name":"Nagamune Hideaki"},{"name":"Matsuda Yoshiko"}],"ja":[{"name":"赤松 徹也"},{"name":"辻 明彦"},{"name":"長宗 秀明"},{"name":"松田 佳子"}]},"event":{"en":"日本生化学会第65回大会","ja":"日本生化学会第65回大会"},"publication_date":"1992-10","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:143, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817538"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383034","label":"url"}],"presentation_title":{"en":"ラット肝α-マクログロブリン-プロテアーゼ複合体の性質","ja":"ラット肝α-マクログロブリン-プロテアーゼ複合体の性質"},"presenters":{"en":[{"name":"Tsuji Akihiko"},{"name":"Akamatsu Tetsuya"},{"name":"尾田 領一"},{"name":"Nagamune Hideaki"},{"name":"Matsuda Yoshiko"}],"ja":[{"name":"辻 明彦"},{"name":"赤松 徹也"},{"name":"尾田 領一"},{"name":"長宗 秀明"},{"name":"松田 佳子"}]},"event":{"en":"日本生化学会中四国支部第55回例会","ja":"日本生化学会中四国支部第55回例会"},"publication_date":"1992-04","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:144, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550718"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=266916","label":"url"}],"presentation_title":{"en":"マウス耳下腺における水チャネルAQP5のイソプロテレノールによるdouwn-regulationの機構","ja":"マウス耳下腺における水チャネルAQP5のイソプロテレノールによるdouwn-regulationの機構"},"presenters":{"en":[{"name":"Yao Chenjuan"},{"name":"Hasegawa Takahiro"},{"name":"Akamatsu Tetsuya"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"姚 陳娟"},{"name":"長谷川 敬展"},{"name":"赤松 徹也"},{"name":"吉村 弘"}]},"event":{"en":"Journal of Oral Biosciences","ja":"Journal of Oral Biosciences"},"languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:145, {"insert":{"user_id":"1000223301","type":"presentations","id":"43527389"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=401612","label":"url"}],"presentation_title":{"en":"イソプロパノール反復投与によるマウス唾液腺機能に及ぼす影響","ja":"イソプロパノール反復投与によるマウス唾液腺機能に及ぼす影響"},"presenters":{"en":[{"name":"Yao Chenjuan"},{"name":"佐藤 匠"},{"name":"Hasegawa Takahiro"},{"name":"Akamatsu Tetsuya"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"姚 陳娟"},{"name":"佐藤 匠"},{"name":"長谷川 敬展"},{"name":"赤松 徹也"},{"name":"吉村 弘"}]},"event":{"en":"第34回唾液腺談話会","ja":"第34回唾液腺談話会"},"publication_date":"2022-09-18","invited":true,"languages":["jpn"],"promoter":{"en":"第34回唾液腺談話会","ja":"第34回唾液腺談話会"},"location":{"en":"Tokushima","ja":"徳島"},"is_international_presentation":false},"priority":"input_data"}
line:146, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550719"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=329738","label":"url"}],"presentation_title":{"en":"Induction of a subtilisin-like proprotein convertase PACE4 in regeneration model of salivary gland Part II","ja":"唾液腺再生モデルにおけるサチライシン様前駆体蛋白質変換酵素PACE4の発現誘導-Part II-"},"presenters":{"en":[{"name":"Tatsuya Shimatani"},{"name":"Makoto Minegishi"},{"name":"Akamatsu Tetsuya"},{"name":"Yao Chenjuan"},{"name":"Hasegawa Takahiro"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"嶋谷 達哉"},{"name":"嶺岸 誠"},{"name":"赤松 徹也"},{"name":"姚 陳娟"},{"name":"長谷川 敬展"},{"name":"吉村 弘"}]},"event":{"en":"Journal of Oral Biosciences","ja":"Journal of Oral Biosciences"},"publication_date":"2016-08","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:147, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550720"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=329733","label":"url"}],"presentation_title":{"en":"Sexual difference in regeneration of salivary gland","ja":"唾液腺再生過程で見られる雌雄差について"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Yao Chenjuan"},{"name":"Hasegawa Takahiro"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"赤松 徹也"},{"name":"姚 陳娟"},{"name":"長谷川 敬展"},{"name":"吉村 弘"}]},"event":{"en":"Journal of Oral Biosciences","ja":"Journal of Oral Biosciences"},"publication_date":"2016-08","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:148, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550721"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=329746","label":"url"}],"presentation_title":{"en":"基礎系教育講演 --- 唾液腺の構造と機能","ja":"基礎系教育講演 --- 唾液腺の構造と機能"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"}],"ja":[{"name":"赤松 徹也"}]},"event":{"en":"Journal of Oral Health and Biosciences","ja":"Journal of Oral Health and Biosciences"},"publication_date":"2016-02","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:149, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550722"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=298267","label":"url"}],"presentation_title":{"en":"唾液腺再生への subtilisin-like proprotein convertase PACE4の関与","ja":"唾液腺再生への subtilisin-like proprotein convertase PACE4の関与"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Yao Chenjuan"},{"name":"Hasegawa Takahiro"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"赤松 徹也"},{"name":"姚 陳娟"},{"name":"長谷川 敬展"},{"name":"吉村 弘"}]},"event":{"en":"自然科学研究機構生理学研究所研究会「唾液腺形態形成研究会~機能解析から器官再生へ~」","ja":"自然科学研究機構生理学研究所研究会「唾液腺形態形成研究会~機能解析から器官再生へ~」"},"publication_date":"2014-08-04","invited":true,"languages":["jpn"],"promoter":{"en":"自然科学研究機構生理学研究所研究会","ja":"自然科学研究機構生理学研究所研究会"},"is_international_presentation":false},"priority":"input_data"}
line:150, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550723"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=266922","label":"url"}],"presentation_title":{"en":"マウス耳下腺における水チャネルAQP5のイソプロテレノールによるdouwn-regulationの機構","ja":"マウス耳下腺における水チャネルAQP5のイソプロテレノールによるdouwn-regulationの機構"},"presenters":{"en":[{"name":"Yao Chenjuan"},{"name":"Hasegawa Takahiro"},{"name":"Akamatsu Tetsuya"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"姚 陳娟"},{"name":"長谷川 敬展"},{"name":"赤松 徹也"},{"name":"吉村 弘"}]},"event":{"en":"第54回歯科基礎医学会","ja":"第54回歯科基礎医学会"},"publication_date":"2012-09-16","languages":["jpn"],"location":{"en":"Koriyama","ja":"郡山"},"is_international_presentation":false},"priority":"input_data"}
line:151, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550724"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=266923","label":"url"}],"presentation_title":{"en":"細胞内cAMP上昇が大脳皮質味覚野から口腔体性感覚野への信号伝播速度に与える影響","ja":"細胞内cAMP上昇が大脳皮質味覚野から口腔体性感覚野への信号伝播速度に与える影響"},"presenters":{"en":[{"name":"Yoshimura Hiroshi"},{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"}],"ja":[{"name":"吉村 弘"},{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"}]},"event":{"en":"第54回歯科基礎医学会","ja":"第54回歯科基礎医学会"},"publication_date":"2012-09-15","languages":["jpn"],"location":{"en":"Koriyama","ja":"郡山"},"is_international_presentation":false},"priority":"input_data"}
line:152, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550725"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=266920","label":"url"}],"presentation_title":{"en":"マウス耳下腺における水チャネルAQP5のイソプロテレノールによるdouwn-regulationの機構","ja":"マウス耳下腺における水チャネルAQP5のイソプロテレノールによるdouwn-regulationの機構"},"presenters":{"en":[{"name":"Yao Chenjuan"},{"name":"Hasegawa Takahiro"},{"name":"Akamatsu Tetsuya"},{"name":"Yoshimura Hiroshi"}],"ja":[{"name":"姚 陳娟"},{"name":"長谷川 敬展"},{"name":"赤松 徹也"},{"name":"吉村 弘"}]},"event":{"en":"Journal of Oral Biosciences","ja":"Journal of Oral Biosciences"},"publication_date":"2012-09","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:153, {"insert":{"user_id":"1000223301","type":"presentations","id":"34550726"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=266918","label":"url"}],"presentation_title":{"en":"細胞内cAMP上昇が大脳皮質味覚野から口腔体性感覚野への信号伝播速度に与える影響","ja":"細胞内cAMP上昇が大脳皮質味覚野から口腔体性感覚野への信号伝播速度に与える影響"},"presenters":{"en":[{"name":"Yoshimura Hiroshi"},{"name":"Hasegawa Takahiro"},{"name":"Yao Chenjuan"},{"name":"Akamatsu Tetsuya"}],"ja":[{"name":"吉村 弘"},{"name":"長谷川 敬展"},{"name":"姚 陳娟"},{"name":"赤松 徹也"}]},"event":{"en":"Journal of Oral Biosciences","ja":"Journal of Oral Biosciences"},"publication_date":"2012-09","languages":["jpn"],"is_international_presentation":false},"priority":"input_data"}
line:154, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817539"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383075","label":"url"}],"presentation_title":{"en":"顎下腺の発生・分化・成熟と機能発現","ja":"顎下腺の発生・分化・成熟と機能発現"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"赤松 徹也"},{"name":"細井 和雄"}]},"event":{"en":"生理学研究所研究会:唾液分泌機構解明に向けての戦略的展開","ja":"生理学研究所研究会:唾液分泌機構解明に向けての戦略的展開"},"publication_date":"2005-02","languages":["jpn"],"location":{"en":"岡崎","ja":"岡崎"},"is_international_presentation":false},"priority":"input_data"}
line:155, {"insert":{"user_id":"1000223301","type":"presentations","id":"35817540"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383068","label":"url"}],"presentation_title":{"en":"ラット顎下腺の発生・分化・成熟と機能発現","ja":"ラット顎下腺の発生・分化・成熟と機能発現"},"presenters":{"en":[{"name":"Akamatsu Tetsuya"},{"name":"Hosoi Kazuo"}],"ja":[{"name":"赤松 徹也"},{"name":"細井 和雄"}]},"event":{"en":"Strategy of infomatics, genomics and proteomics for salivary secretion research","ja":"生理学研究所研究会"},"publication_date":"2004-02","location":{"en":"岡崎","ja":"岡崎"},"is_international_presentation":false},"priority":"input_data"}
==== end registerFile(/WWW/pub2/data/ERD/person/60376/researchmap/presentations.jsonl, 0AE6HI8B7kacV6CWw06l) ====
====== BulkResult(1000223301, ugE6HI8B7kacV6CWvk6C) : Begin ======
--- error
{"code":304,"status":"completion","start_datetime":"2024-04-26T21:26:44Z","end_datetime":"2024-04-26T21:26:44Z","estimated_end_datetime":"2024-04-26T21:26:45Z","total_items":42}

--- success
{"code":304,"status":"completion","start_datetime":"2024-04-26T21:26:44Z","end_datetime":"2024-04-26T21:26:44Z","estimated_end_datetime":"2024-04-26T21:26:45Z","total_items":42}
{"no":1,"line":1,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"42436046","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/42436046","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=42436046]。"}]}
{"no":1,"line":2,"code":304,"action":"insert","action_type":"merge","type":"published_papers","id":"39296851","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/39296851","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =39296851]。"}]}
{"no":1,"line":3,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"34550659","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/34550659","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=34550659]。"}]}
{"no":1,"line":4,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"34550660","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/34550660","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=34550660]。"}]}
{"no":1,"line":5,"code":304,"action":"insert","action_type":"merge","type":"published_papers","id":"34550661","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/34550661","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550661]。"}]}
{"no":1,"line":6,"code":304,"action":"insert","action_type":"merge","type":"published_papers","id":"34550662","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/34550662","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550662]。"}]}
{"no":1,"line":7,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"25838193","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/25838193","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=25838193]。"}]}
{"no":1,"line":8,"code":304,"action":"insert","action_type":"merge","type":"published_papers","id":"34550663","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/34550663","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550663]。"}]}
{"no":1,"line":9,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"25838154","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/25838154","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=25838154]。"}]}
{"no":1,"line":10,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"26927011","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/26927011","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=26927011]。"}]}
{"no":1,"line":11,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"25838182","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/25838182","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=25838182]。"}]}
{"no":1,"line":12,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"25911431","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/25911431","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=25911431]。"}]}
{"no":1,"line":13,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"25838184","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/25838184","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=25838184]。"}]}
{"no":1,"line":14,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"25838186","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/25838186","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=25838186]。"}]}
{"no":1,"line":15,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"25838187","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/25838187","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=25838187]。"}]}
{"no":1,"line":16,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"25838189","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/25838189","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=25838189]。"}]}
{"no":1,"line":17,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"25838190","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/25838190","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=25838190]。"}]}
{"no":1,"line":18,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"25838192","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/25838192","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=25838192]。"}]}
{"no":1,"line":19,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"23667191","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/23667191","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=23667191]。"}]}
{"no":1,"line":20,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"23667192","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/23667192","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=23667192]。"}]}
{"no":1,"line":21,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"23667193","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/23667193","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=23667193]。"}]}
{"no":1,"line":22,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"23667194","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/23667194","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=23667194]。"}]}
{"no":1,"line":23,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"23667173","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/23667173","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=23667173]。"}]}
{"no":1,"line":24,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"23667174","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/23667174","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=23667174]。"}]}
{"no":1,"line":25,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"23667175","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/23667175","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=23667175]。"}]}
{"no":1,"line":26,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"23667176","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/23667176","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=23667176]。"}]}
{"no":1,"line":27,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"23667200","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/23667200","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=23667200]。"}]}
{"no":1,"line":28,"code":304,"action":"insert","action_type":"merge","type":"published_papers","id":"23667201","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/23667201","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =23667201]。"}]}
{"no":1,"line":29,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"23667179","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/23667179","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=23667179]。"}]}
{"no":1,"line":30,"code":304,"action":"insert","action_type":"merge","type":"published_papers","id":"23667204","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/23667204","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =23667204]。"}]}
{"no":1,"line":31,"code":304,"action":"insert","action_type":"merge","type":"published_papers","id":"23667206","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/23667206","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =23667206]。"}]}
{"no":1,"line":32,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"23667181","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/23667181","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=23667181]。"}]}
{"no":1,"line":33,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"23667207","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/23667207","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=23667207]。"}]}
{"no":1,"line":34,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"23667209","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/23667209","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=23667209]。"}]}
{"no":1,"line":35,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"23667183","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/23667183","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=23667183]。"}]}
{"no":1,"line":36,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"23667188","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/23667188","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=23667188]。"}]}
{"no":1,"line":37,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"34550664","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/34550664","messages":[{"code":304,"message":"not_similar_modified","message_description":"本人相当が登録した類似の業績が存在したため、更新しませんでした[id=23667211]。"}]}
{"no":1,"line":38,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"23667212","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/23667212","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=23667212]。"}]}
{"no":1,"line":39,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"23667215","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/23667215","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=23667215]。"}]}
{"no":1,"line":40,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"23667216","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/23667216","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=23667216]。"}]}
{"no":1,"line":41,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"23667202","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/23667202","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=23667202]。"}]}
{"no":1,"line":42,"code":304,"action":"insert","action_type":"force","type":"published_papers","id":"34550617","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/34550617","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=34550617]。"}]}
====== BulkResult(1000223301, ugE6HI8B7kacV6CWvk6C) : End ======
====== BulkResult(1000223301, vwE6HI8B7kacV6CWwE6A) : Begin ======
--- error
{"code":304,"status":"completion","start_datetime":"2024-04-26T21:26:50Z","end_datetime":"2024-04-26T21:26:50Z","estimated_end_datetime":"2024-04-26T21:26:51Z","total_items":14}

--- success
{"code":304,"status":"completion","start_datetime":"2024-04-26T21:26:50Z","end_datetime":"2024-04-26T21:26:50Z","estimated_end_datetime":"2024-04-26T21:26:51Z","total_items":14}
{"no":1,"line":1,"code":304,"action":"insert","action_type":"similar_merge","priority":"input_data","type":"published_papers","id":"34393258","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/34393258","messages":[{"code":304,"message":"not_similar_modified","message_description":"本人相当が登録した類似の業績が存在したため、更新しませんでした[id=34393258]。"}]}
{"no":1,"line":2,"code":304,"action":"insert","action_type":"similar_merge","priority":"input_data","type":"published_papers","id":"29832355","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/29832355","messages":[{"code":304,"message":"not_similar_modified","message_description":"本人相当が登録した類似の業績が存在したため、更新しませんでした[id=29832355]。"}]}
{"no":1,"line":3,"code":304,"action":"insert","action_type":"similar_merge","priority":"input_data","type":"published_papers","id":"23667214","link":"https://api.researchmap.jp/read0188854_Akamatsu/published_papers/23667214","messages":[{"code":304,"message":"not_similar_modified","message_description":"本人相当が登録した類似の業績が存在したため、更新しませんでした[id=23667214]。"}]}
{"no":1,"line":4,"code":304,"action":"insert","action_type":"merge","type":"misc","id":"34550618","link":"https://api.researchmap.jp/read0188854_Akamatsu/misc/34550618","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550618]。"}]}
{"no":1,"line":5,"code":304,"action":"insert","action_type":"merge","type":"misc","id":"34550619","link":"https://api.researchmap.jp/read0188854_Akamatsu/misc/34550619","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550619]。"}]}
{"no":1,"line":6,"code":304,"action":"insert","action_type":"merge","type":"misc","id":"34550620","link":"https://api.researchmap.jp/read0188854_Akamatsu/misc/34550620","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550620]。"}]}
{"no":1,"line":7,"code":200,"action":"insert","action_type":"force","type":"misc","id":"34550621","link":"https://api.researchmap.jp/read0188854_Akamatsu/misc/34550621"}
{"no":1,"line":8,"code":200,"action":"insert","action_type":"force","type":"misc","id":"34550622","link":"https://api.researchmap.jp/read0188854_Akamatsu/misc/34550622"}
{"no":1,"line":9,"code":304,"action":"insert","action_type":"merge","type":"misc","id":"34550669","link":"https://api.researchmap.jp/read0188854_Akamatsu/misc/34550669","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550669]。"}]}
{"no":1,"line":10,"code":304,"action":"insert","action_type":"force","type":"misc","id":"23667195","link":"https://api.researchmap.jp/read0188854_Akamatsu/misc/23667195","messages":[{"code":304,"message":"not_modified","message_description":"本人相当が登録した既存データが存在したため、更新しませんでした[id=23667195]。"}]}
{"no":1,"line":11,"code":304,"action":"insert","action_type":"merge","type":"misc","id":"34550668","link":"https://api.researchmap.jp/read0188854_Akamatsu/misc/34550668","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550668]。"}]}
{"no":1,"line":12,"code":304,"action":"insert","action_type":"merge","type":"misc","id":"34550667","link":"https://api.researchmap.jp/read0188854_Akamatsu/misc/34550667","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550667]。"}]}
{"no":1,"line":13,"code":304,"action":"insert","action_type":"merge","type":"misc","id":"34550666","link":"https://api.researchmap.jp/read0188854_Akamatsu/misc/34550666","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550666]。"}]}
{"no":1,"line":14,"code":304,"action":"insert","action_type":"merge","type":"misc","id":"34550665","link":"https://api.researchmap.jp/read0188854_Akamatsu/misc/34550665","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550665]。"}]}
====== BulkResult(1000223301, vwE6HI8B7kacV6CWwE6A) : End ======
====== BulkResult(1000223301, xgE6HI8B7kacV6CWwU5A) : Begin ======
--- error
{"code":304,"status":"completion","start_datetime":"2024-04-26T21:26:39Z","end_datetime":"2024-04-26T21:26:39Z","estimated_end_datetime":"2024-04-26T21:26:40Z","total_items":5}

--- success
{"code":304,"status":"completion","start_datetime":"2024-04-26T21:26:39Z","end_datetime":"2024-04-26T21:26:39Z","estimated_end_datetime":"2024-04-26T21:26:40Z","total_items":5}
{"no":1,"line":1,"code":304,"action":"insert","action_type":"merge","type":"books_etc","id":"34550738","link":"https://api.researchmap.jp/read0188854_Akamatsu/books_etc/34550738","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550738]。"}]}
{"no":1,"line":2,"code":304,"action":"insert","action_type":"merge","type":"books_etc","id":"35817447","link":"https://api.researchmap.jp/read0188854_Akamatsu/books_etc/35817447","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817447]。"}]}
{"no":1,"line":3,"code":304,"action":"insert","action_type":"merge","type":"books_etc","id":"34550739","link":"https://api.researchmap.jp/read0188854_Akamatsu/books_etc/34550739","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550739]。"}]}
{"no":1,"line":4,"code":304,"action":"insert","action_type":"merge","type":"books_etc","id":"6594856","link":"https://api.researchmap.jp/read0188854_Akamatsu/books_etc/6594856","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =6594856]。"}]}
{"no":1,"line":5,"code":304,"action":"insert","action_type":"merge","type":"books_etc","id":"34550740","link":"https://api.researchmap.jp/read0188854_Akamatsu/books_etc/34550740","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550740]。"}]}
====== BulkResult(1000223301, xgE6HI8B7kacV6CWwU5A) : End ======
====== BulkResult(1000223301, ywE6HI8B7kacV6CWwk4U) : Begin ======
--- error
{"code":304,"status":"completion","start_datetime":"2024-04-26T21:26:34Z","end_datetime":"2024-04-26T21:26:34Z","estimated_end_datetime":"2024-04-26T21:26:35Z","total_items":7}

--- success
{"code":304,"status":"completion","start_datetime":"2024-04-26T21:26:34Z","end_datetime":"2024-04-26T21:26:34Z","estimated_end_datetime":"2024-04-26T21:26:35Z","total_items":7}
{"no":1,"line":1,"code":304,"action":"insert","action_type":"merge","type":"awards","id":"34550754","link":"https://api.researchmap.jp/read0188854_Akamatsu/awards/34550754","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550754]。"}]}
{"no":1,"line":2,"code":304,"action":"insert","action_type":"merge","type":"awards","id":"34550755","link":"https://api.researchmap.jp/read0188854_Akamatsu/awards/34550755","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550755]。"}]}
{"no":1,"line":3,"code":304,"action":"insert","action_type":"merge","type":"awards","id":"34550756","link":"https://api.researchmap.jp/read0188854_Akamatsu/awards/34550756","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550756]。"}]}
{"no":1,"line":4,"code":304,"action":"insert","action_type":"merge","type":"awards","id":"34550757","link":"https://api.researchmap.jp/read0188854_Akamatsu/awards/34550757","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550757]。"}]}
{"no":1,"line":5,"code":304,"action":"insert","action_type":"merge","type":"awards","id":"34550758","link":"https://api.researchmap.jp/read0188854_Akamatsu/awards/34550758","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550758]。"}]}
{"no":1,"line":6,"code":304,"action":"insert","action_type":"merge","type":"awards","id":"34550759","link":"https://api.researchmap.jp/read0188854_Akamatsu/awards/34550759","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550759]。"}]}
{"no":1,"line":7,"code":304,"action":"insert","action_type":"merge","type":"awards","id":"34550760","link":"https://api.researchmap.jp/read0188854_Akamatsu/awards/34550760","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550760]。"}]}
====== BulkResult(1000223301, ywE6HI8B7kacV6CWwk4U) : End ======
====== BulkResult(1000223301, 0AE6HI8B7kacV6CWw06l) : Begin ======
--- error
{"code":304,"status":"completion","start_datetime":"2024-04-26T21:26:57Z","end_datetime":"2024-04-26T21:26:57Z","estimated_end_datetime":"2024-04-26T21:26:59Z","total_items":155}

--- success
{"code":304,"status":"completion","start_datetime":"2024-04-26T21:26:57Z","end_datetime":"2024-04-26T21:26:57Z","estimated_end_datetime":"2024-04-26T21:26:59Z","total_items":155}
{"no":1,"line":1,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550672","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550672","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550672]。"}]}
{"no":1,"line":2,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550673","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550673","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550673]。"}]}
{"no":1,"line":3,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550674","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550674","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550674]。"}]}
{"no":1,"line":4,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550675","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550675","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550675]。"}]}
{"no":1,"line":5,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550676","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550676","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550676]。"}]}
{"no":1,"line":6,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550677","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550677","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550677]。"}]}
{"no":1,"line":7,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550678","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550678","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550678]。"}]}
{"no":1,"line":8,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550679","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550679","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550679]。"}]}
{"no":1,"line":9,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550680","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550680","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550680]。"}]}
{"no":1,"line":10,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550681","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550681","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550681]。"}]}
{"no":1,"line":11,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550682","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550682","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550682]。"}]}
{"no":1,"line":12,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817448","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817448","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817448]。"}]}
{"no":1,"line":13,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817449","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817449","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817449]。"}]}
{"no":1,"line":14,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817450","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817450","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817450]。"}]}
{"no":1,"line":15,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817451","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817451","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817451]。"}]}
{"no":1,"line":16,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817452","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817452","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817452]。"}]}
{"no":1,"line":17,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817453","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817453","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817453]。"}]}
{"no":1,"line":18,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817454","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817454","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817454]。"}]}
{"no":1,"line":19,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817455","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817455","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817455]。"}]}
{"no":1,"line":20,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817456","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817456","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817456]。"}]}
{"no":1,"line":21,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817457","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817457","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817457]。"}]}
{"no":1,"line":22,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817458","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817458","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817458]。"}]}
{"no":1,"line":23,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817459","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817459","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817459]。"}]}
{"no":1,"line":24,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817460","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817460","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817460]。"}]}
{"no":1,"line":25,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817461","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817461","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817461]。"}]}
{"no":1,"line":26,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817462","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817462","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817462]。"}]}
{"no":1,"line":27,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817463","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817463","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817463]。"}]}
{"no":1,"line":28,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817464","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817464","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817464]。"}]}
{"no":1,"line":29,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817465","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817465","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817465]。"}]}
{"no":1,"line":30,"code":200,"action":"insert","action_type":"force","type":"presentations","id":"35817466","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817466"}
{"no":1,"line":31,"code":200,"action":"insert","action_type":"force","type":"presentations","id":"35817467","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817467"}
{"no":1,"line":32,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817468","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817468","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817468]。"}]}
{"no":1,"line":33,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817469","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817469","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817469]。"}]}
{"no":1,"line":34,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817470","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817470","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817470]。"}]}
{"no":1,"line":35,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550683","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550683","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550683]。"}]}
{"no":1,"line":36,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817471","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817471","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817471]。"}]}
{"no":1,"line":37,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817472","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817472","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817472]。"}]}
{"no":1,"line":38,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550684","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550684","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550684]。"}]}
{"no":1,"line":39,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817473","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817473","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817473]。"}]}
{"no":1,"line":40,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"43049173","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/43049173","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =43049173]。"}]}
{"no":1,"line":41,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"43049174","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/43049174","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =43049174]。"}]}
{"no":1,"line":42,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"36201537","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/36201537","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =36201537]。"}]}
{"no":1,"line":43,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"36266338","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/36266338","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =36266338]。"}]}
{"no":1,"line":44,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"39705162","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/39705162","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =39705162]。"}]}
{"no":1,"line":45,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"39296853","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/39296853","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =39296853]。"}]}
{"no":1,"line":46,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"36266339","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/36266339","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =36266339]。"}]}
{"no":1,"line":47,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550689","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550689","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550689]。"}]}
{"no":1,"line":48,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550685","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550685","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550685]。"}]}
{"no":1,"line":49,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550690","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550690","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550690]。"}]}
{"no":1,"line":50,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550691","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550691","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550691]。"}]}
{"no":1,"line":51,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550692","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550692","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550692]。"}]}
{"no":1,"line":52,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550693","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550693","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550693]。"}]}
{"no":1,"line":53,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550694","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550694","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550694]。"}]}
{"no":1,"line":54,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550695","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550695","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550695]。"}]}
{"no":1,"line":55,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550696","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550696","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550696]。"}]}
{"no":1,"line":56,"code":200,"action":"insert","action_type":"force","type":"presentations","id":"34550697","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550697"}
{"no":1,"line":57,"code":200,"action":"insert","action_type":"force","type":"presentations","id":"34550698","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550698"}
{"no":1,"line":58,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550699","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550699","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550699]。"}]}
{"no":1,"line":59,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550700","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550700","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550700]。"}]}
{"no":1,"line":60,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550701","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550701","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550701]。"}]}
{"no":1,"line":61,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550702","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550702","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550702]。"}]}
{"no":1,"line":62,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550703","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550703","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550703]。"}]}
{"no":1,"line":63,"code":200,"action":"insert","action_type":"force","type":"presentations","id":"34550686","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550686"}
{"no":1,"line":64,"code":200,"action":"insert","action_type":"force","type":"presentations","id":"34550704","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550704"}
{"no":1,"line":65,"code":200,"action":"insert","action_type":"force","type":"presentations","id":"34550705","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550705"}
{"no":1,"line":66,"code":200,"action":"insert","action_type":"force","type":"presentations","id":"34550687","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550687"}
{"no":1,"line":67,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550706","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550706","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550706]。"}]}
{"no":1,"line":68,"code":200,"action":"insert","action_type":"force","type":"presentations","id":"34550707","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550707"}
{"no":1,"line":69,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550688","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550688","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550688]。"}]}
{"no":1,"line":70,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550708","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550708","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550708]。"}]}
{"no":1,"line":71,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550709","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550709","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550709]。"}]}
{"no":1,"line":72,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550710","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550710","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550710]。"}]}
{"no":1,"line":73,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550711","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550711","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550711]。"}]}
{"no":1,"line":74,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550713","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550713","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550713]。"}]}
{"no":1,"line":75,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550714","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550714","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550714]。"}]}
{"no":1,"line":76,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550715","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550715","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550715]。"}]}
{"no":1,"line":77,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817474","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817474","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817474]。"}]}
{"no":1,"line":78,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817475","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817475","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817475]。"}]}
{"no":1,"line":79,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817476","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817476","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817476]。"}]}
{"no":1,"line":80,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817477","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817477","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817477]。"}]}
{"no":1,"line":81,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817478","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817478","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817478]。"}]}
{"no":1,"line":82,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817479","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817479","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817479]。"}]}
{"no":1,"line":83,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817480","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817480","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817480]。"}]}
{"no":1,"line":84,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817481","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817481","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817481]。"}]}
{"no":1,"line":85,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817482","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817482","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817482]。"}]}
{"no":1,"line":86,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817483","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817483","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817483]。"}]}
{"no":1,"line":87,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817484","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817484","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817484]。"}]}
{"no":1,"line":88,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817485","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817485","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817485]。"}]}
{"no":1,"line":89,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550716","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550716","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550716]。"}]}
{"no":1,"line":90,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817486","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817486","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817486]。"}]}
{"no":1,"line":91,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817487","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817487","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817487]。"}]}
{"no":1,"line":92,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817488","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817488","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817488]。"}]}
{"no":1,"line":93,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817489","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817489","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817489]。"}]}
{"no":1,"line":94,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817490","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817490","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817490]。"}]}
{"no":1,"line":95,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817491","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817491","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817491]。"}]}
{"no":1,"line":96,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817492","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817492","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817492]。"}]}
{"no":1,"line":97,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817493","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817493","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817493]。"}]}
{"no":1,"line":98,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550717","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550717","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550717]。"}]}
{"no":1,"line":99,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817494","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817494","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817494]。"}]}
{"no":1,"line":100,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817495","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817495","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817495]。"}]}
{"no":1,"line":101,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817496","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817496","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817496]。"}]}
{"no":1,"line":102,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817497","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817497","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817497]。"}]}
{"no":1,"line":103,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817498","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817498","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817498]。"}]}
{"no":1,"line":104,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817499","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817499","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817499]。"}]}
{"no":1,"line":105,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817500","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817500","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817500]。"}]}
{"no":1,"line":106,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817501","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817501","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817501]。"}]}
{"no":1,"line":107,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817502","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817502","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817502]。"}]}
{"no":1,"line":108,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817503","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817503","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817503]。"}]}
{"no":1,"line":109,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817504","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817504","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817504]。"}]}
{"no":1,"line":110,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817505","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817505","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817505]。"}]}
{"no":1,"line":111,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817506","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817506","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817506]。"}]}
{"no":1,"line":112,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817507","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817507","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817507]。"}]}
{"no":1,"line":113,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817508","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817508","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817508]。"}]}
{"no":1,"line":114,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817509","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817509","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817509]。"}]}
{"no":1,"line":115,"code":200,"action":"insert","action_type":"force","type":"presentations","id":"35817510","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817510"}
{"no":1,"line":116,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817511","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817511","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817511]。"}]}
{"no":1,"line":117,"code":200,"action":"insert","action_type":"force","type":"presentations","id":"35817512","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817512"}
{"no":1,"line":118,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817513","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817513","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817513]。"}]}
{"no":1,"line":119,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817514","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817514","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817514]。"}]}
{"no":1,"line":120,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817515","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817515","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817515]。"}]}
{"no":1,"line":121,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817516","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817516","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817516]。"}]}
{"no":1,"line":122,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817517","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817517","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817517]。"}]}
{"no":1,"line":123,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817518","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817518","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817518]。"}]}
{"no":1,"line":124,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817519","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817519","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817519]。"}]}
{"no":1,"line":125,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817520","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817520","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817520]。"}]}
{"no":1,"line":126,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817521","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817521","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817521]。"}]}
{"no":1,"line":127,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817522","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817522","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817522]。"}]}
{"no":1,"line":128,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817523","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817523","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817523]。"}]}
{"no":1,"line":129,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817524","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817524","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817524]。"}]}
{"no":1,"line":130,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817525","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817525","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817525]。"}]}
{"no":1,"line":131,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817526","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817526","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817526]。"}]}
{"no":1,"line":132,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817527","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817527","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817527]。"}]}
{"no":1,"line":133,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817528","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817528","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817528]。"}]}
{"no":1,"line":134,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817529","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817529","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817529]。"}]}
{"no":1,"line":135,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817530","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817530","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817530]。"}]}
{"no":1,"line":136,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817531","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817531","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817531]。"}]}
{"no":1,"line":137,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817532","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817532","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817532]。"}]}
{"no":1,"line":138,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817533","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817533","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817533]。"}]}
{"no":1,"line":139,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817534","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817534","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817534]。"}]}
{"no":1,"line":140,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817535","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817535","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817535]。"}]}
{"no":1,"line":141,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817536","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817536","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817536]。"}]}
{"no":1,"line":142,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817537","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817537","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817537]。"}]}
{"no":1,"line":143,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817538","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817538","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817538]。"}]}
{"no":1,"line":144,"code":200,"action":"insert","action_type":"force","type":"presentations","id":"34550718","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550718"}
{"no":1,"line":145,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"43527389","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/43527389","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =43527389]。"}]}
{"no":1,"line":146,"code":200,"action":"insert","action_type":"force","type":"presentations","id":"34550719","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550719"}
{"no":1,"line":147,"code":200,"action":"insert","action_type":"force","type":"presentations","id":"34550720","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550720"}
{"no":1,"line":148,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550721","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550721","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550721]。"}]}
{"no":1,"line":149,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550722","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550722","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550722]。"}]}
{"no":1,"line":150,"code":200,"action":"insert","action_type":"force","type":"presentations","id":"34550723","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550723"}
{"no":1,"line":151,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550724","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550724","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550724]。"}]}
{"no":1,"line":152,"code":200,"action":"insert","action_type":"force","type":"presentations","id":"34550725","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550725"}
{"no":1,"line":153,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"34550726","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/34550726","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =34550726]。"}]}
{"no":1,"line":154,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817539","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817539","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817539]。"}]}
{"no":1,"line":155,"code":304,"action":"insert","action_type":"merge","type":"presentations","id":"35817540","link":"https://api.researchmap.jp/read0188854_Akamatsu/presentations/35817540","messages":[{"code":304,"message":"not_changed","message_description":"変更はないので、更新されませんでした[id =35817540]。"}]}
====== BulkResult(1000223301, 0AE6HI8B7kacV6CWw06l) : End ======