type: misc

label: url

en: 歯周病が全身に及ぼす影響

ja: 歯周病が全身に及ぼす影響

en: KAO HEALTH CARE REPORT

ja: KAO HEALTH CARE REPORT


en: Streptococcus anginosus group感染症 ―口腔細菌感染症が全身へ及ぼす影響―

en: Evolvere

ja: Evolvere


en: Dd診断力てすと 歯肉と頬粘膜の白色病変

ja: Dd診断力てすと 歯肉と頬粘膜の白色病変

en: デンタルダイアモンド

ja: デンタルダイアモンド


en: 歯肉頬移行部の腫瘤

ja: 歯肉頬移行部の腫瘤

en: DENTAL DIAMOND

ja: デンタルダイヤモンド


en: 歯内療法における技術革新と最近のトレンド・トピックス

ja: 歯内療法における技術革新と最近のトレンド・トピックス

en: The Japanese Journal of Conservative Dentistry

ja: 日本歯科保存学雑誌


en: 歯内療法における技術革新

ja: 歯内療法における技術革新


en: ``撥菌''∼口腔バイオフィルム感染症予防への応用∼

ja: ``撥菌''∼口腔バイオフィルム感染症予防への応用∼

en: The Journal of Educational Conference on All Japan Colleges of Dental Hygiene

ja: 全国大学歯科衛生士教育協議会雑誌


en: 歯周病およびNETsとがんを含む全身疾患

ja: 歯周病およびNETsとがんを含む全身疾患

ja: 全国大学歯科衛生士教育協議会雑誌


en: Various roles of calprotectin in periodontal disease and its possibility as a diagnostic marker for periodontal disease

ja: カルプロテクチンの歯周病病態における多様な役割と歯周病診断マーカーとしての可能性

en: Journal of the Japanese Association of Periodontology

ja: 日本歯周病学会会誌


en: 高周波電流の根尖性歯周炎への応用

ja: 高周波電流の根尖性歯周炎への応用

en: 歯内療法学会雑誌

ja: 歯内療法学会雑誌


en: X線写真で認められた根尖部透過像

ja: X線写真で認められた根尖部透過像


en: 糖尿病と慢性腎疾患(CKD)

ja: 糖尿病と慢性腎疾患(CKD)

en: 月刊糖尿病

ja: 月刊糖尿病


en: 女児に認められた上顎前歯部の歯肉腫脹

ja: 女児に認められた上顎前歯部の歯肉腫脹


en: The Roles of Odontoblasts in Dental Pulp Innate Immunity

en: Odontoblasts located in the outermost layer of dental pulp form a natural barrier between mineralized tissues, dentin, and soft tissues, dental pulp, of the vital tooth, and they first recognize caries-related pathogens and sense external irritations. Therefore, odontoblasts possess a specialized innate immune system to fight oral pathogens invading into dentin. Generally, the rapid initial sensing of microbial pathogens, especially pathogen-associated molecular patterns (PAMPs) shared by microorganisms, are mediated by pattern recognition receptors (PRRs), such as Toll-like receptor and the nucleotide-binding oligomerization domain (NOD). The innate immune responses in odontoblasts initiated by sensing oral pathogens provide host protective events, such as inflammatory reactions, to produce a variety of pro-inflammatory mediators, including chemokines and cytokines. These attract various inflammatory cells and cause antibacterial reactions, such as the production of defensins, to kill microorganisms in the proximal region of the odontoblast layer. This review focuses on innate immunity, especially cellular and molecular mechanisms regarding the sensing of PAMPs from oral pathogens by PRRs, in odontoblasts and provides information for future studies for the development of novel therapeutic strategies, including diagnosis and treatment, to prevent exceeding dental pulp inflammation and preserve the dental pulp tissues.

en: Japanese Dental Science Review

ja: Japanese Dental Science Review


en: Pathogenic Factors in Oral Biofilm Infection and Their Effects on Systemic Diseases

ja: 口腔Biofilm感染症における病原因子と全身に及ぼす影響

en: Oral infectious diseases, such as dental caries and periodontitis, are caused by oral biofilm, so-called dental plaque. The foundation of the biofilm structure is the extracellular polymeric substances consisting of polysaccharides, toxins, proteins and nucleic acids as well as vesicles, which secrete these components outside of bacterial cells. Among them, extracellular DNA(eDNA) has become increasingly recognized as a key component for biofilm formation and its structural stability. Bacterial histone-like DNA binding protein(HLP), an accessory architectural protein in a variety of bacterial cellular processes due to DNA and mRNA binding capacity, also contributes to the activation of host innate immunity during bacterial infection. Moreover, it has been suggested that vesicles harboring DNA are associated with horizontal gene transfer. In recent two decades, numerous studies regarding the association between oral biofilm infectious diseases and various systemic diseases, such as cardiovascular diseases, atherosclerosis, diabetes mellitus, aspiration pneumonia and autoimmune diseases, have been reported. Besides bacteria, <i>Candida</i> spp., which are frequently implicated in mixed bacterial-fungal infections in humans, can readily form biofilms on the surfaces of denture and cause a variety of infectious diseases ranging from denture stomatitis in denture wearers to life-threatening invasive infections, such as aspiration pneumonia, particularly in immunocompromised and elderly populations. From the viewpoint of biofilm infection, which cause systemic diseases as well as oral infectious diseases, the development of new preventive and therapeutic procedures targeting bacterial-derived pathogenic factors such as eDNA, HLP and vesicle, is expected in future studies.

ja: Oral infectious diseases, such as dental caries and periodontitis, are caused by oral biofilm, so-called dental plaque. The foundation of the biofilm structure is the extracellular polymeric substances consisting of polysaccharides, toxins, proteins and nucleic acids as well as vesicles, which secrete these components outside of bacterial cells. Among them, extracellular DNA (eDNA) has become increasingly recognized as a key component for biofilm formation and its structural stability. Bacterial histone-like DNA binding protein (HLP), an accessory architectural protein in a variety of bacterial cellular processes due to DNA and mRNA binding capacity, also contributes to the activation of host innate immunity during bacterial infection. Moreover, it has been suggested that vesicles harboring DNA are associated with horizontal gene transfer. In recent two decades, numerous studies regarding the association between oral biofilm infectious diseases and various systemic diseases, such as cardiovascular diseases, atherosclerosis, diabetes mellitus, aspiration pneumonia and autoimmune diseases, have been reported. Besides bacteria, Candida spp., which are frequently implicated in mixed bacterial–fungal infections in humans, can readily form biofilms on the surfaces of denture and cause a variety of infectious diseases ranging from denture stomatitis in denture wearers to life-threatening invasive infections, such as aspiration pneumonia, particularly in immunocompromised and elderly populations. From the viewpoint of biofilm infection, which cause systemic diseases as well as oral infectious diseases, the development of new preventive and therapeutic procedures targeting bacterial-derived pathogenic factors such as eDNA, HLP and vesicle, is expected in future studies.

en: Journal of Oral Health and Biosciences

ja: Journal of Oral Health and Biosciences


en: 歯根側面に認められたX線透過像

ja: 歯根側面に認められたX線透過像


en: Pulp pathosis and its diagnosis

ja: 歯髄疾患の病態と診断

en: The Journal of Japan Endodontic Association

ja: 日本歯内療法学会雑誌


en: 心臓血管疾患と歯周病 –動脈硬化症への歯周病原性細菌感染のかかわり-

ja: 心臓血管疾患と歯周病 –動脈硬化症への歯周病原性細菌感染のかかわり-

en: the Quintessence

ja: ザ·クインテッセンス


en: 抗生物質利用におけるEBM(根拠に基づく医学)を考える

ja: 抗生物質利用におけるEBM(根拠に基づく医学)を考える

en: 日本ヘルスケア歯科研究会誌

ja: 日本ヘルスケア歯科研究会誌


en: 義歯とカンジダ

ja: 義歯とカンジダ

en: Medicine and Drug Journal

ja: 医薬ジャーナル


en: Caries-A disease of bacteria infection

ja: Caries-A disease of bacteria infection

en: Caries Preventive restoration

ja: Caries Preventive restoration


en: The role of gingival epithelial cells in innate immune of periodontal disease

ja: 歯周炎発症における歯肉上皮細胞の役割

en: Shikoku Dental Research

ja: 四国歯学会雑誌


en: 歯周病原性細菌は口腔内にどのように定着するか 新たな診断·予防法の開発に向けて

ja: 歯周病原性細菌は口腔内にどのように定着するか 新たな診断·予防法の開発に向けて

en: 化学と生物

ja: 化学と生物