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en: Relationship of oral conditions to the incidence of infective endocarditis in periodontitis patients with valvular heart disease: a cross-sectional study.

en: The patients with IE had fewer remaining teeth, more advanced bone resorption compared with those of patients without IE. These findings suggest a possible association between the occurrence of IE and periodontal infection.

ja: No significant differences were observed between patients with or without VHD in oral conditions. A significant increase in the percentage of alveolar bone loss in VHD patients with IE was observed compared with that of patients without IE. The ratio of both Porphyromonas gingivalis (Pg) IgG titer > 1.68 and Pg fimA type II genotype in patients with IE was significantly higher than in patients without IE. There was a significant correlation between the occurrence of IE and clinical oral findings (number of remaining teeth: OR, 0.17; rate of alveolar bone loss > 40%: OR, 11.8).

en: Clinical Oral Investigations

ja: Clinical Oral Investigations


en: The pathogenic factors from oral Streptococci for systemic diseases

en: International Journal of Molecular Sciences


en: Management of tooth extraction in a patient with ELANE gene mutation-induced cyclic neutropenia: A case report.

en: Cyclic neutropenia (CyN) is a rare hematological disease, and patients with CyN often experience an early onset of severe periodontitis and are forced to undergo tooth extraction. Here, we report a case of a patient with CyN who showed different periodicity and oscillations of neutrophil count compared with her mother, despite sharing the same novel genetic mutation. A 17-year-old Japanese girl who had been diagnosed with CyN shortly after birth presented to our hospital with a complaint of mobility of her teeth and gingivitis. Upon presentation, an intraoral examination was performed and revealed redness and swelling of the marginal and attached gingiva. Radiographs revealed extreme resorption of the alveolar bone and apical lesions in her mandibular lateral incisors. The patient's hematologic data demonstrated a lack of blood neutrophils (0/μL). The patient had no history of dental extraction, and her mother also had a history of CyN. The patient was diagnosed with severe periodontitis that was associated with CyN. Gene testing showed a novel heterozygous mutation in exon 4 of the ELANE gene (c.538delC, p.Leu180Ser fsX11). Based on the clinical findings, we planned to extract the patient's mandibular lateral incisors. Although the tooth extraction was scheduled considering the cyclic variation in neutrophil count, the patient's neutrophil count was 0/μL on the day before the planned extraction. Therefore, granulocyte-colony stimulating factor (G-CSF) was administered to increase the patient's neutrophil count. On the day of the patient's admission for the tooth extraction, she presented with fever (body temperature, 38.5°C), tonsillitis, and stomatitis. The extraction was subsequently delayed, and the patient was administered antibiotics and G-CSF for 4 days. At this time, the neutrophil count increased to 750/μL, and the tooth extraction was carried out safely. The postoperative course was uneventful, and the healing process at the extraction site was excellent. There is a possibility that the periodicity and oscillations of neutrophil count may change with growth in patients with CyN. Therefore, it is important to frequently examine and treat patients with fluctuating neutrophil levels for the management of invasive dental treatment in patients with CyN.

en: Medicine

ja: Medicine


en: Report of comprehensive periodontal treatment of a case of severe drug-induced gingival overgrowth with malaligned teeth

ja: 歯列不正を伴う重度薬物性歯肉増殖症患者に対して包括的歯周治療を行った一症例

en: Journal of the Japanese Association of Periodontology

ja: 日本歯周病学会会誌


en: Journal of Oral Health and Biosciences

ja: Journal of Oral Health and Biosciences


en: Association between Periodontal Condition and Kidney Dysfunction in Japanese Adults: A Cross-Sectional Study

en: Clinical and Experimental Dental Research


en: 口腔ならびに呼吸器症状を呈した歯科用金属によるアレルギーの1例

ja: 口腔ならびに呼吸器症状を呈した歯科用金属によるアレルギーの1例

en: Journal of Japanese Society for Evidence and the Dental Professional

ja: 日本口腔検査学会雑誌


en: Successful case of periodontal tissue repair by fibroblast growth factor-2. -Long-term follow-up and comparison with enamel matrix derivative-

en: Clinical Advances in Periodontics

ja: Clinical Advances in Periodontics


en: エナメル基質タンパクの歯の移植への応用

ja: エナメル基質タンパクの歯の移植への応用

en: the Quintessence

ja: ザ·クインテッセンス


en: MMP 阻害剤の歯槽骨吸収抑制作用

ja: MMP 阻害剤の歯槽骨吸収抑制作用


en: Application of Enamel Matrix Derivative in Autotransplantation of an Impacted Maxillary Premolar

en: The success of tooth transplantation or replantation depends on the viability of periodontal ligament in the planted tooth. Mechanical injury to periodontal tissues frequently results in dental root resorption and dental ankylosis, which leads to the failure of transplantation or replantation. Enamel matrix derivative (EMD) has been recently used to induce periodontal regeneration. In this report, we show a clinical case of EMD application in the transplantation of an inversely impacted and immature tooth. An impacted second premolar was found in the right maxilla of a 16 year-old girl. The tooth was inversely impacted and the dental root was incomplete. When transplantation was carried out, EMD was applied to the periodontal tissues of the extracted premolar. The tooth was fixed at the correct position and the clinical condition was followed for evaluation for 6 months. Radiographs after 3 months exhibited new bone formation surrounding the transplanted tooth. After 6 months, considerable growth of dental root was evident, periodontal ligament-like radiolucency appeared, the vital reaction of the planted tooth was detected, and there were no signs of root resorption or ankylosis. Short-term results from this case indicate that EMD application was effective in the transplantation of an inversely impacted and immature tooth and that EMD might contribute to the growth of dental root and to the prevention of ankylosis.

en: Journal of Periodontology

ja: Journal of Periodontology


en: Autotransplantation of Impacted Teeth and Wisdom Teeth

ja: 智歯·埋伏歯の移植

en: Shikoku Dental Research

ja: 四国歯学会雑誌


en: Immunohistochemical Localization of Osteopontin in human Pulp Stones.

en: The organic matrix component of human pulp stones was investigated by immunohistochemistry. Two pulp stones were extracted from the upper molar teeth of two patients suffering from irreversible pulpitis. Both were formed in the center of the pulp cavity and located apart from the dentin walls. After demineralization, serial sections of the stones were prepared and subjected to immunohistochemical procedures using specific antibodies to type I collagen and noncollagenous proteins (osteopontin, osteonectin, and osteocalcin), which are reported to be involved in calcified matrix formation. Type I collagen was localized evenly in the stones, indicating that it is a major matrix component of pulp stones. Strong immunostaining of osteopontin appeared in the peripheral area of the stones, whereas osteonectin and osteocalcin were not detected. We previously reported that dental pulp cells produced osteopontin in vitro. Osteopontin has been commonly found in other pathological calcification, such as urinary stones, atherosclerotic plaques, and dental calculus. Taken together, the present findings suggest that osteopontin produced by dental pulp cells is possibly associated with calcification of the pulp stone matrix.

en: Journal of Endodontics

ja: Journal of Endodontics


en: Cyclosporin A Decreases the Degradation of Type I Collagen in Rat Gingival Overgrowth

en: Cyclosporin A (CsA) is used as an immunosuppressive agent and its prominent side effect is the induction of fibrous gingival overgrowth. The purpose of this study was to investigate the effect of CsA on the type I collagen metabolism in the gingiva of rats fed a powdered diet either containing or lacking CsA. Immunohistochemical analysis revealed that type I collagen was more prevalent in the connective tissue of CsA-treated gingiva than in those of control rats on days 15, 30, and 55 after the start of feeding. Total RNAs were isolated from mandibular molar gingiva on days 0, 3, 8, 15, 30, and 55. Quantitative analysis of mRNA by reverse transcriptase-polymerase chain reaction revealed that the CsA-treated groups showed a gradual decrease in expression of type I collagen and collagenase mRNAs, 0.4% and 18.0% on day 55 compared with those on day 0, respectively. In the control groups, type I collagen and collagenase mRNAs also decreased to 19.7% and 63.0%, respectively, however, both mRNA expressions were significantly lower in the CsA-treated group than in the controls. An electron microscopic analysis of fibroblasts was performed to count the number of cells with collagen fibrils in the cytoplasm, a marker of phagocytosis of collagen by fibroblasts. The collagen fibrils were detected in 4.7% +/- 2.7% and 24.3% +/- 13.7% of fibroblasts in the overgrown gingiva treated with CsA rat for 8 days and 30 days, but in 57.0% +/- 5.3% and 81.3% +/- 9.2% of fibroblasts in the each control group gingiva, respectively. Furthermore, in vitro analysis was performed to measure the phagocytosis of cultured fibroblasts by flow cytometry using collagen-coated latex beads. Fibroblasts isolated from CsA-treated gingiva on day 8 and day 30 contained 5.7% +/- 0.6% and 9.9% +/- 1.5% phagocytic cells, whereas control fibroblasts contained 50.3% +/- 5.5% and 33.3% +/- 4.9% phagocytic cells, respectively. The inhibition rate of phagocytic activity was similar between in vivo and in vitro assays. These findings suggest that the decrease of the collagen degradation due to the lower phagocytosis and the lower collagenase mRNA expression are closely associated with the increase of type I collagen accumulation in CsA-treated rat gingiva.

en: Journal of Cellular Physiology

ja: Journal of Cellular Physiology


en: ハムスター実験的歯周炎におけるプロスタグランディンE2の歯槽骨吸収抑制効果

ja: ハムスター実験的歯周炎におけるプロスタグランディンE2の歯槽骨吸収抑制効果

en: The Japanese Society of Conservative Dentistry

ja: 日本歯科保存学会雑誌


en: Stimulatory Effects of Phenytoin on Osteoblastic Differentiation in Cultured MC3 T3-E1 Cells

ja: 培養骨芽細胞MC3T3-E1におけるフェニトインの分化促進作用

en: Journal of the Japanese Association of Periodontology


en: Comparative histological study of mineralizations after intramuscular Implantations of heat-denatured demineralized bone matrix gelatin,heat-denatured demineralized tooth, and cross-linked collagen

ja: 熱変性脱灰骨基質ゼラチン，熱変性脱灰歯，および架橋コラーゲンの筋肉内移植後に認められた石灰化の組織学的比較


en: ラット後肢の指骨切断後の治癒過程に及ぼすethane-1-hydroxy-1, 1-diphosphonateの影響—光学顕微鏡所見を中心に—


en: Human alveolar bone cells in vitro

ja: Human alveolar bone cells in vitro

en: Biomedical Research (India)

ja: Biomedical Research (India)


en: Histological study on endochondral ossification in the osteopetrotic op/op mouse

en: Dentistry in Japan

ja: Dentistry in Japan


en: Inhibitory Effects of Prostaglandin E2 on Alveolar Bone Resorption in Hamster Experimental Periodontitis

ja: ハムスター実験的歯周炎におけるプロスタグランディンE2の歯槽骨吸収抑制効果

en: The Japanese Journal of Conservative Dentistry

ja: 日本歯科保存学雑誌


en: Diagnosis of Periodontal Diseases using Biomarkers in Gingival Crevicular Fluid

ja: 歯肉溝滲出液中のバイオマーカーを用いた歯周病診断

en: Periodontal diseases cause an inflammation and degradation of periodontal tissues and missing of teeth. The incidence rate of periodontal diseases is high in middle-aged and elderly people.A reasonable diagnosis of periodontal diseases is very important to keep teeth, however, conventional examinations of periodontal diseases is not necessarily exact and objective. Gingival crevicular fluid (GCF) is an exudate secreted from periodontal tissues and contains many components including proteolytic enzymes, inflammatory cytokines, blood-associated proteins, cellular and bacterial fragments. Because some proteins in GCF are related to inflammation, tissue degradation and bone metabolism, those proteins have been studying as a diagnostic marker of periodontal diseases. GCF is noninvasively collected using a sterile paper strip and biomarkers are determined using enzyme-linked immunosorbent assay (ELISA) and enzyme activity assay. We identified calprotectin, an inflammationrelated protein, in GCF and calprotectin level in GCF from periodontitis sites was significantly higher than that of healthy control. Calprotectin level in GCF was positively correlated to gingival index and other biomarkers and decreased by periodontal treatments. Resistin is an adipocytokine and its level increases in some inflammatory diseases. Resistin level in GCF from periodontitis sites was high compared to the level of healthy control samples. Procollagen type I C-terminal peptide (PICP) is a biomarker for bone metabolism and its level was high in GCF collected from periodontitis sites. These results suggested that calprotectin, resistin and PICP are useful biomarkers for periodontal diseases. On the other hand, we showed that glycated albumin (GA), a marker of diabetes mellitus (DM), was contained in GCF and GA level in GCF from DM patients was significantly higher than that of non-DM individuals. Components in GCF may be biomarkers of systemic diseases as well as periodontal diseases and their determination will be useful diagnostic examination of some diseases. Recently, we have been studying the determining system of GCF calprotectin, including microchip ELISA, surface plasmon resonance assay and immuno-chromatography assay. When GCF biomarkers are determined using the determining systems, we will simply, exactly and objectively diagnose periodontal diseases at our dental offices.

en: Journal of Oral Health and Biosciences


en: FGF-2による歯周組織再生療法

ja: FGF-2による歯周組織再生療法

en: 歯の長期保存の臨床 私はこうして歯を守る

ja: 歯の長期保存の臨床 私はこうして歯を守る


en: Periodontal Tissue Regeneration by Fibroblast Growth Factor-2

ja: FGF-2による再生療法

en: 31th Proceedings 臨床歯科を語る会

ja: 31th Proceedings 臨床歯科を語る会


en: カラーアトラス:皮膚・粘膜の下，透けて見えますか --- 歯科医師・口腔外科医に必要な解剖学の知識

en: Dental Outlook

ja: 歯界展望


en: Hypercementosis with the progression of chronic apical periodontitis -A case report

ja: 慢性根尖性歯周炎の進行に伴って形成されたセメント質過形成症

en: Shikoku Dental Research