Effect of the additional installation of implants in the posterior region on the prognosis of treatment in the edentulous mandibular jaw

The aim of this study was to elucidate the effect of the additional installation of implants in the posterior region on the prognosis of treatment in the edentulous mandibular jaw. Fifteen patients who had received implants (Brånemark system, Nobel Biocare, Gotebörg, Sweden) in the edentulous mandible and completed a 1-year follow-up after the fitting of implant-anchored fixed prostheses were selected. In seven patients (Group A), four or five implants were installed between the mental foramina, and in eight patients (Group P), one or two implants, one on each side, were installed in the posterior regions in addition to the implants between the foramina. All implants of both groups achieved osseointegration. In Group A, there was no implant loss after loading. Six implants were lost in five patients of Group P within 1 year after loading. All of them were located in the posterior region. To elucidate whether or not the failure rate of the implants in the posterior region of Group P after loading was especially high, the failures were also compared with 89 implants, which were installed in the posterior region of the mandibles to support implant-anchored fixed partial prosthesis, during the same period (Group C). The cumulative survival rate of the implants of Group P was 60%, while that of the implants of Group C was 100% (P<0.001). When the survival rates of posterior implants with the same length of the two groups were compared, there were significant differences for the 7- and 10-mm-length implants only. These data demonstrate that the posterior implants in Group P are at greater risk. Deformation of the mandible due to jaw movement was thought to be the most likely cause of the implant loss. Therefore, when such modified treatment is chosen, it should be performed with meticulous attention.


Basic fibroblast growth factor and epidermal growth factor reverse impaired ulcer healing of the rabbit oral mucosa


Evaluation of Risk Factors Concerning Loss of Osseointegration of Dental Implant

歯科インプラントのオッセオインテグレーション喪失に関与するリスクファクターの検討

Journal of Japanese Society of Oral Implantology

日本口腔インプラント学会誌


Traumatized Alveolar Bone Defect with Recovery of Oral Functions Using Vertical Alveolar Distraction Osteogenesis and Immediate Loading Implant:A Case Report

垂直的歯槽骨延長と即時荷重インプラントによって機能回復を図った外傷性歯槽骨欠損の1例


下顎骨関節突起骨折の臨床的検討

下顎骨関節突起骨折の臨床的検討

Journal of the Japanese Society for the Temporomandibular Joint


Use Experience with an Implant-Type Distractor for Vertical Alveolar Distraction Osteogenesis

垂直的歯槽骨延長におけるインプラント型骨延長器の使用経験

日本口腔インプラント学会誌


Clinical statistical study of jaw deformity patients at the Department of Orthodontics, Tokushima University Dental Hospital

徳島大学歯学部附属病院矯正歯科における顎変形症患者の臨床統計学的検討


クローズドロックに対するパンピング·マニピュレーション，上関節腔洗浄療法について


Evaluation of Clinical Factors Conserning Osseointegration Establishment of a Dental Implant

歯科インプラントのオッセオインテグレーション獲得に関与する臨床的要因の検討

日本口腔インプラント学会誌


The in vitro antibiotic release from anti-washout apatite cement using chitosan (aw-AC(chi)) was investigated in a preliminary evaluation. Flomoxef sodium was employed as the antibiotic and was incorporated into the powder phase aw-AC(chi) at up to 10%. The setting times were measured for aw-AC(chi) containing various amounts of flomoxef sodium. X-ray diffraction (XRD) analysis was also conducted for the identification of products. To evaluate the drug release profile, set aw-AC was immersed in saline and the released flomoxef sodium was determined at regular intervals. The setting time was prolonged slightly with the addition of flomoxef sodium. The difference at 10% flomoxef sodium (0% vs. 10%) was not significant (p>0.05), and can be negligible in clinic. The XRD analysis revealed that formation of hydroxyapatite (HAP) from aw-AC(chi) was reduced, even after 24 h, when the aw-AC(chi) contained flomoxef sodium at 8% or more. The flomoxef sodium release from aw-AC(chi) showed the typical profile observed in skeleton type drug delivery system (DDS). Changing the concentration of chitosan can control the rate of drug release from aw-AC. Therefore, we conclude that aw-AC(chi) is a good candidate for potential use as a DDS carrier that may be useful in surgical operations.

Journal of Materials Science. Materials in Medicine


Surface-layer modification of hydroxyapatite ceramic with acid and heat treatments

The purpose of this study was to examine or characterize the surface layer of a calcium phosphate ceramic with a gradual compositional change from alpha-tricalcium phosphate (alpha-TCP) on the surface to hydroxyapatite (HAP) on the inside. The surface of a dense HAP ceramic was acid-treated for 1 hour with orthophosphoric acid (H3PO4) solutions of several concentrations (0.5, 1.0 and 5.0 mol/L) or a buffered solution (pH 4.0) consisting of phosphate solutions. After acid treatment, specimens were heat-treated at 1,250 degrees C for 1 hour. X-ray photoelectron spectroscopy revealed that the compositional gradient layer could be modified on the surface of the HAP ceramic with all acid and heat treatments, and that 5.0 mol/L H3PO4 solution and heat treatments had a maximal thickness of approximately 2 microm for the surface-modified layer. It was confirmed that the outermost layer of HAP ceramics modified with the treatments, except 5.0 mol/L H3PO4 solution, showed a compound such alpha-TCP.


Hydrothermal modification of titanium surface in calcium solutions

Hydrothermal modification of a titanium surface in calcium solutions was performed. The apatite precipitation on the modified surface in Hanks' solution, as a simulated body fluid, was evaluated and the surface microstructure changes after the modification were characterized by thin-film X-ray diffractometry (TF-XRD) and X-ray photoelectron spectroscopy (XPS). Hydrothermal modification in CaO solution enhanced the precipitation of apatite on the titanium surface. High pH, high pressure and high temperature of the CaO solution increased the thickness of the surface-modified layer and enhanced the synthesis of calcium titanate which possibly promoted the precipitation of apatite in Hanks' solution. Hydrothermal modification in CaCl2 solution, on the other hand, showed reverse effects. The modification of titanium in CaO solution with hydrothermal treatment is expected to result in excellent osteointegration and can be easily performed by using an autoclave, a clinical apparatus widely used.


Fabrication of Zn containing apatite cement and its initial evaluation using human osteoblastic cells

Recently, the effects of Zn2+ on osteogenesis stimulation have become major topics in the research fields of bone formation and organism essential elements. Based on the fundamental finding of Zn2+ with respect to osteogenesis stimulation, Ito et al. have prepared Zn doped beta-tricalcium phosphate (ZnTCP) and have reported that ZnTCP enhances the proliferation of MC3T3-E1 cells. In this investigation, we studied the effects of ZnTCP added to apatite cement (AC) with respect to its setting reaction and proliferation of human osteoblastic cells as an initial evaluation for the feasibility of AC containing ZnTCP. Compositional analysis using powder X-ray diffractometer revealed that ZnTCP shows no reactivity with the setting reaction of AC. As a result, the mechanical strength of set AC decreased increasing amounts of added ZnTCP as if ZnTCP acts as a pore in AC. The setting time of AC was not affected by addition of ZnTCP up to 10%. When AC containing ZnTCP was immersed in alpha-MEM containing 10% bovine serum, Zn2+ was released from AC. Larger amounts of Zn2+ were released from AC containing larger amounts of ZnTCP. When human osteoblastic cells were incubated on the surface of AC discs, proliferation of human osteoblastic cells was significantly increased on the surface of AC that contained 5% ZnTCP when compared with that containing no ZnTCP. In contrast, proliferation of human osteoblastic cells decreased on the surface of AC that contained 10% ZnTCP when compared with that free from ZnTCP; indicating cytotoxicity. We concluded therefore, that addition of ZnTCP to AC is useful to enhance the osteoconductivity of AC when release of Zn2+ can be carefully regulated.


Effects of powder phase sterilization on basic properties of apatite cement


Evaluation of Feasibility of Hydroxyapatite Putty as a Local Hemostatic Agent for Bone.

Although bone wax is known to cause an inflammatory reaction in soft tissue and a delay of bone healing, it is usually the first choice to arrest bleeding from bone. Hydroxyapatite (HAP) putty is proposed here. This study evaluated the feasibility of HAP putty with respect to whether or not it has potential value as a hemostatic agent for bone. First, the adhesive strength of HAP putty to bone was evaluated. The adhesive strength of HAP putty to wet bone was much higher when compared with that of bone wax, even though the adhesive strengths of HAP putty and bone wax to dry bone were equivalent. Next, to evaluate the hemostatic ability of HAP putty, bony defects were made in rabbits. HAP putty could arrest bleeding from bone within 3 min. However, when the hemostasis was performed with bone wax, bleeding was arrested within 8 min. Thus, HAP putty showed better hemostatic ability than bone wax. Finally, the tissue response to HAP putty in rabbit subcutaneous tissue was evaluated. Histological observation revealed a slight inflammatory response around HAP putty, whereas bone wax was surrounded by moderate inflammatory tissue. In conclusion, HAP putty has good potential value to be a hemostatic agent for bone because it has strong adhesion, good hemostatic ability, and biocompatibility.

Journal of Biomedical Materials Research


Tissue responses to anti-washout apatite cement using chitosan when implanted in the rat tibia

The tissue response to anti-washout apatite cement using chitosan (aw-AC(chi)) was evaluated by implanting aw-AC(chi) into bone defects of rat tibiae using conventional apatite cement (c-AC) as a control material. During the experimental period up to 16 weeks, the only difference between aw-AC and c-AC was found at two weeks in the tissue response of soft tissue. At two weeks, c-AC showed a moderate inflammatory response; small particles of c-AC were scattered in the cutaneous tissue and many foreign body giant cells were collected around the scattered c-AC, whereas aw-AC showed only a slight inflammatory response and few foreign body giant cells. We found no difference between aw-AC(chi) and c-AC with respect to bone tissue response. Both AC were almost completely surrounded by mature bone at eight weeks. No promotion or reduction of osteoconductivity was observed by chitosan even though it is considered to promote bone formation. We concluded, therefore, that enhancement of bone formation cannot be expected by employing chitosan to obtain anti-washout properties, at least in the concentration used in this study, even though aw-AC(chi) is much more useful than c-AC.


Effect of added NaHCO3 on the basic properties of apatite cement

Alternation of a composition of set apatite cement (AC) from carbonate-free apatite (CO3-free AP) to carbonate apatite (CO3-AP) may accelerate replacement of the set AC with bone because CO3-AP can be dissolved much faster than CO3-free AP in the weak acidic solution produced by osteoclasts. In this investigation, NaHCO3 was added to the AC component and the effects of added NaHCO3 on cement-setting behavior and on set mass were studied as an initial step for the fabrication of AC, which can be replaced with bone faster than current AC. When NaHCO3 was added to AC, the resultant set mass contained CO3. Although not all CO3 was incorporated in the set AC, the amount of CO3 incorporated into the set AC increased with the amount of added NaHCO3. Powder X-ray diffraction analysis and Fourier transform infrared spectrometer measurements revealed the formation of B-type CO3-AP. The setting time measured in an incubator at 37 degrees C and 100% relative humidity slowed from 30 to 45 min, indicating that NaHCO3 has an inhibitory effect on AP formation. The diametral tensile strength of the set AC decreased significantly with the addition of NaHCO3. Scanning electron microscopic observation revealed that fine crystals were formed in the set AC when NaHCO3 was added to AC. As a result, the crystallinity indices of the set AC measured using X-ray diffraction and Fourier transform infrared spectroscopy decreased with an increase in the amount of added NaHCO3. The dissolution rate of set AC in weak acid, pH 5.5, increased with the amount of added NaHCO3. We concluded that the formation of B-type CO3-AP and the resulting faster dissolution of set AC in weak acidic solution is preferable for the faster replacement of set AC with bone even though the decreased diametral tensile strength value is a shortcoming.


In vitro resorption of three apatite cements with osteoclasts

To evaluate the replacement of apatite cement (AC) with bone, osteoclasts were incubated for 48 h on the surface of three AC types: conventional AC (c-AC), fast-setting AC (fs-AC), and anti-washout AC (aw-AC), using sintered apatite (AP) and cortical bone as control materials. We found osteoclasts attached to the surface of AC and osteoclastic resorption pits after 48 h of incubation for all experimental AC types. In contrast, no resorption pit was observed on the surface of sintered AP although osteoclasts were attached to the surface of sintered AP. There was no significant difference among the types of AC with respect to the resorption area, but the resorption areas were only approximately 1% of that on the surface of cortical bone. We concluded, therefore, that ACs could be replaced with bone regardless of the type but that it takes extensive time for the ACs to be completely replaced with bone.


A case of first and second branchial arch syndrome in a patient whose profile and occlusion improved in response to orthognatic surgery

顎矯正手術により顔貌および咬合の改善が得られた第1·第2鰓弓症候群の1例

We describe a case of first and second branchial arch syndrome in a patient whose profile and occlusion improved in response to orthognatic surgery.<BR>A 2-year-9-month-old boy was referred to our clinic for the treatment of open bite. Because symptoms were mild the patient was placed under observation. However, open bite and bird face became severer as he grew older. Cephalometric analysis indicated mandibular micrognathia. Before operation, we made and analyzed computer tomography-based three-dimensional models. The models were very useful for operation planning. After preoperative orthodontic treatment, sagittal splitting ramus osteotomy and horizontal sliding advancement genioplasty were performed in two stages.

Japanese Journal of Oral & Maxillofacial Surgery


徳島県立ひのみね整肢医療センター歯科における心身障害児(者)の診療実態について

徳島県立ひのみね整肢医療センター歯科における心身障害児(者)の診療実態について


Histological and compositional evaluations of three types of calcium phosphate cements when implanted in subcutaneous tissue immediately after mixing

To evaluate the soft tissue response of calcium phosphate cement (CPC), consisting of an equimolar mixture of tetracalcium phosphate (TTCP) and dicalcium phosphate anhydrous (DCPA) under conditions close to those encountered in actual surgical procedures, we implanted three types of CPC [conventional CPC (c-CPC), fast-setting CPC (FSCPC), and antiwashout type FSCPC (aw-FSCPC; formerly called nondecay type FSCPC or nd-FSCPC)] subcutaneously in the abdomens of rats immediately (1 min) after mixing. At 1 week after surgery, histological examination and compositional analysis were performed using light microscopy and powder X-ray diffraction (XRD), respectively. The implanted c-CPC was crumbled completely, whereas FSCPC and aw-FSCPC retained their shape. Large vesicles containing copious inflammatory effusion were subcutaneously formed around the c-CPC. Histologically, many foreign-body giant cells were collected around the c-CPC, and moderate inflammatory cell infiltration was observed at 1 week after surgery. In contrast, the FSCPC and aw-FSCPC were covered with a thin layer of granulation tissue that included few giant cells and presented slight inflammatory cell infiltration, and no effusion was observed. The XRD analysis of the c-CPC revealed the presence of some unreacted DCPA even 1 week after implantation, whereas almost no DCPA was found in the FSCPC or aw-FSCPC. In conclusion, it was found that CPC does not always show excellent tissue response. When c-CPC is implanted subcutaneously in rats immediately after mixing, it fails to set and causes a severe inflammatory response. Therefore, the type of CPC should be chosen according to the clinical particulars. CPC should be used in a manner that assures its setting reaction. We recommend the use of FSCPC and aw-FSCPC for surgical applications, such as orthopedics, plastic and reconstructive surgery, and oral and maxillofacial surgery, where the cement might otherwise crumble due to the pressure before setting.


Ultrastructures of the sublingual and interpapillar surface of the human tongue


Effects of added antibiotics on the basic properties of anti-washout-type fast-setting calcium phosphate cements


Three Cases of Application of Osseointegrated Implant to Surgical Reconstructive Area in Oral Cancer Patients --- Discussion of the Management of Reconstructive Soft Tissue Surrounding Implants

口腔癌切除後の外科的再建部へオッセオインテグレーテッドインプラントを応用した3例 --- インプラント周囲の外科的再建組織の処理法に関する考察

Journal of Japanese Society of Oral Implantology

日本口腔インプラント学会誌


Development of calcium phosphate cement for rapid crystallization to apatite


Basic properties of calcium phosphate cement containing atelocollagen in its liquid or powder phases


Initial histological evaluation of anti-washout type fast-setting calcium phosphate cement following subcutaneous implantation


Surface modification of titanium in calcium-ion-containing solutions

Journal of Biomedical Materials Research


Non-decay type fast-setting calcium phosphate cement: Hydroxyapatite putty containing an increased amount of sodium alginate


Blast coating method: New method of coating titanium surface with hydroxyapatite at room temperature


Tissue response to fast-setting calcium phosphate cement in bone


Carcinoma in Pleomorphic Adenoma of the Tongue ; Report of a case

A carcinoma in pleomorphic adenoma occurring in the tongue of a 47-year-old Japanese woman is reported. The present report is the first to describe a carcinoma in pleomorphic adenoma derived from the posterior lingual glands.


Verruciform xanthoma occurring within oral lichen planus


Non-decay type fast-setting calcium phosphate cement: setting behaviour in calf serum and its tissue response


Soft tissue response of calcium phosphate cements


Basic properties of hydroxyapatite putty made with fast-setting calcium phosphate cement and sodium alginate


Non-decay type fast-setting calcium phosphate cement using chitosan

Journal of Materials Science Materials in Medicine


Non-decay type fast-setting calcium phosphate cement --- : Composite with sodium alginate


Development of calcium phosphate based functional gradient bioceramics


In vivo setting behavior of fast-setting calcium phosphate cement

The in vivo setting behaviour of fast-setting calcium phosphate cement (FSCPC) between femoral muscles of the rat was investigated to evaluate the possible value of FSCPC for medical and dental application. Conventional CPC (c-CPC) and FSCPC were implanted between femoral muscles, and various aspects of the setting behaviour such as setting time, mechanical strength and conversion ratio of cement into hydroxyapatite (HAP: Ca10(PO4)6(OH)2) were measured by the Vicat needle method, diametral tensile strength (DTS) measurement, and quantitative powder X-ray diffraction (XRD) analysis, respectively. The setting time of FSCPC in vivo was 5-7 min, in contrast to 48 min for c-CPC. As a result of its fast setting, set specimens of FSCPC showed higher mechanical strength from the initial stage than c-CPC. Higher DTS values were observed in FSCPC than c-CPC implanted after 24 h. Powder XRD analysis revealed faster conversion of FSCPC than c-CPC into HAP, which was responsible both for the faster setting and higher mechanical strength from the initial stage. We concluded, therefore, that FSCPC may be used for a wide range of clinical applications, i.e. fields where fast setting is required such as orthopaedic, plastic and reconstructive, and oral and maxillofacial surgery.


過去10年間のガマ腫39症例の臨床的検討

過去10年間のガマ腫39症例の臨床的検討

Journal of The Japanese Stomatological Society


維持透析患者に生じた舌癌の1治験例

維持透析患者に生じた舌癌の1治験例

Japanese Journal of Oral & Maxillofacial Surgery


顎下腺と肺の重複癌の1例

顎下腺と肺の重複癌の1例


セメント質形成線維腫の4例


Lung carcinoma suspected to metastarize to the submandibular region by the autopsy --- Report of a case

剖検により原発性肺癌の顎下部転移と考えられた1例 --- Report of a case


A Cleft Child With Lobulated Tongue and Lingual Hamartoma: Report of a Case

Journal of Oral and Maxillofacial Surgery


Solitary neurofibroma of the tongue: Report of a case

舌に孤立性に生じた神経線維腫の1例


Light-and Electron-Microscopic Observations on the Mandibular Condylar Cartilages in Growing Rats on a Low-Calcium Diet

In order to obtain more insight into the physiologic mechanism of endochondral ossification, histological changes occurring in the mandibular condylar cartilage of growing rats fed on a low-calcium diet were investigated by light and electron microscopy. Twenty-three-day-old rats were fed on a normal diet or a low-calcium diet for 8 weeks. For the histological observations the mandibular condyles were dissected from each animal at 1, 2, 4, 5 and 8 weeks after the initiation of the experiment. Histological changes occurring in the mandibular condylar cartilages of the rats fed on a low-calcium diet were as follows: (1) narrow proliferative and mature cell zones and a wide hypertrophic cell zone, (2) inhibition of development of cell organelles in the mature chondrocytes, (3) decrease in dead cells in the proliferative zone, (4) decrease in glycogen accumulation in the chondrocytes and (5) inhibition of calcification in the extracellular matrix of the hypertrophic cell zone. Additionally at the end of the experimental period, the following findings were observed: (1) appearance of small light cells in the mature cell zone and the hypertrophic cell zone and (2) decrease in proteoglycan granules and appearance of large collagen fibrils in the pericellular region of the hypertrophic cell zone.


当科における5年間の小児入院患者の臨床統計的観察

当科における5年間の小児入院患者の臨床統計的観察


マウス(BALB/c)二次口蓋突起癒合に関する研究 --- 変性細胞の分布と上皮細胞の移動について


On the double relief pattern of incisors and the central tubercles of premolars


口腔悪性腫瘍に対するPepleomycin使用についての臨床的検討

口腔悪性腫瘍に対するPepleomycin使用についての臨床的検討


The Current Situation of Carbonate Apatite as a Noble Bone Substitute and Its Future Development in the Oral Region

口腔領域における骨補填材としての炭酸アパタイトの現状と今後の展開

Journal of Japanese Society of Oral Implantology

日本口腔インプラント学会誌


Physical and Histological Comparison of Hydroxyapatite, Carbonate Apatite, and -Tricalcium Phosphate Bone Substitutes.

Three commercially available artificial bone substitutes with different compositions, hydroxyapatite (HAp; Neobone), carbonate apatite (CO3Ap; Cytrans), and β-tricalcium phosphate (β-TCP; Cerasorb), were compared with respect to their physical properties and tissue response to bone, using hybrid dogs. Both Neobone (HAp) and Cerasorb (β-TCP) were porous, whereas Cytrans (CO3Ap) was dense. Crystallite size and specific surface area (SSA) of Neobone (HAp), Cytrans (CO3Ap), and Cerasorb (β-TCP) were 75.4 ± 0.9 nm, 30.8 ± 0.8 nm, and 78.5 ± 7.5 nm, and 0.06 m²/g, 18.2 m²/g, and 1.0 m²/g, respectively. These values are consistent with the fact that both Neobone (HAp) and Cerasorb (β-TCP) are sintered ceramics, whereas Cytrans (CO3Ap) is fabricated in aqueous solution. Dissolution in pH 5.3 solution mimicking Howship's lacunae was fastest in CO3Ap (Cytrans), whereas dissolution in pH 7.3 physiological solution was fastest in β-TCP (Cerasorb). These results indicated that CO3Ap is stable under physiological conditions and is resorbed at Howship's lacunae. Histological evaluation using hybrid dog mandible bone defect model revealed that new bone was formed from existing bone to the center of the bone defect when reconstructed with CO3Ap (Cytrans) at week 4. The amount of bone increased at week 12, and resorption of the CO3Ap (Cytrans) was confirmed. β-TCP (Cerasorb) showed limited bone formation at week 4. However, a larger amount of bone was observed at week 12. Among these three bone substitutes, CO3Ap (Cytrans) demonstrated the highest level of new bone formation. These results indicate the possibility that bone substitutes with compositions similar to that of bone may have properties similar to those of bone.


カラーアトラス:皮膚・粘膜の下，透けて見えますか --- 歯科医師・口腔外科医に必要な解剖学の知識


歯科局所麻酔時に必要な解剖学の知識 --- より効果的な麻酔を目指して

歯科局所麻酔時に必要な解剖学の知識 --- より効果的な麻酔を目指して

「見える! わかる! 臨床に役立つ解剖写真集 5」，歯界展望

「見える! わかる! 臨床に役立つ解剖写真集 5」，歯界展望


口腔外科の視点からみた即時荷重インプラント

口腔外科の視点からみた即時荷重インプラント

補綴臨床 別冊 即時インプラント

補綴臨床 別冊 即時インプラント


歯科インプラントの安定性評価のための共鳴振動周波数分析装置「オステル」について

歯科インプラントの安定性評価のための共鳴振動周波数分析装置「オステル」について


Evaluation of bioceramics containing a-tricalcium phosphate


Influences of crystal phases on bioactivity of calcium phosphate cements


Soft tissue responses of calcium phosphate cements


Basic properties of hydroxyapatite putty made with fast-setting calcium phosphate cement and sodium alginate


Approaches for bone-replacing calcium phosphate cement --- Effect of NaHCO3 addition on the properties of calcium phosphate cement