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en: Clinical Key Points of Class II Direct Composite Restoration

ja: 2級コンポジットレジン修復のキーポイント

en: Journal of Oral Health and Biosciences

ja: Journal of Oral Health and Biosciences


en: Possibility of applying caffeic acid phenethyl ester to the treatment of pulpitis

ja: 歯髄炎治療におけるカフェイン酸フェネチルエステル応用の可能性

en: Medical Science Digest

ja: メディカル・サイエンス・ダイジェスト


en: 深在性う蝕への対応と歯髄の免疫応答

ja: 深在性う蝕への対応と歯髄の免疫応答

en: The Japanese Journal of Conservative Dentistry

ja: 日本歯科保存学雑誌


en: The Roles of Odontoblasts in Dental Pulp Innate Immunity

en: Odontoblasts located in the outermost layer of dental pulp form a natural barrier between mineralized tissues, dentin, and soft tissues, dental pulp, of the vital tooth, and they first recognize caries-related pathogens and sense external irritations. Therefore, odontoblasts possess a specialized innate immune system to fight oral pathogens invading into dentin. Generally, the rapid initial sensing of microbial pathogens, especially pathogen-associated molecular patterns (PAMPs) shared by microorganisms, are mediated by pattern recognition receptors (PRRs), such as Toll-like receptor and the nucleotide-binding oligomerization domain (NOD). The innate immune responses in odontoblasts initiated by sensing oral pathogens provide host protective events, such as inflammatory reactions, to produce a variety of pro-inflammatory mediators, including chemokines and cytokines. These attract various inflammatory cells and cause antibacterial reactions, such as the production of defensins, to kill microorganisms in the proximal region of the odontoblast layer. This review focuses on innate immunity, especially cellular and molecular mechanisms regarding the sensing of PAMPs from oral pathogens by PRRs, in odontoblasts and provides information for future studies for the development of novel therapeutic strategies, including diagnosis and treatment, to prevent exceeding dental pulp inflammation and preserve the dental pulp tissues.

en: Japanese Dental Science Review

ja: Japanese Dental Science Review


en: 感染根管における細菌感染の実態

ja: 感染根管における細菌感染の実態

en: The Nippon Dental Review

ja: 日本歯科評論


en: 歯髄炎の病態形成における細菌侵襲と歯髄の反応性

ja: 歯髄炎の病態形成における細菌侵襲と歯髄の反応性


en: Pulp pathosis and its diagnosis

ja: 歯髄疾患の病態と診断

en: The Journal of Japan Endodontic Association

ja: 日本歯内療法学会雑誌


en: 歯髄炎の病態形成における細菌侵襲と歯髄の反応性

ja: 歯髄炎の病態形成における細菌侵襲と歯髄の反応性


en: Pharmacologic Control of Dental Pain

ja: 8 薬物による歯痛制御

en: the Quintessence

ja: ザ·クインテッセンス


en: Expresion of Chemokines in periodontitis

ja: 歯周炎とケモカイン

en: Clinical Immunology

ja: 臨床免疫


en: Bacterial irritation and pulpal response in pulpitis

ja: 歯髄炎の病態形成における細菌侵襲と歯髄反応

en: Shikoku Dental Research

ja: 四国歯学会雑誌


en: Pathology of Apical Periodontitis Refractory to endod

ja: 難治性根尖性歯周炎 病理と病態

en: 現代の根管治療の診断科学

ja: 現代の根管治療の診断科学