read0046140/published_papers/14797272 Kimiko Ueda Yamaguchi 上田(山口) 公子 Yukiko Kori 郡由紀子 Hiroshi Nakagawa 中川弘 Tsutomu Iwamoto 岩本勉自閉スペクトラム症児者の特性と歯科受診時の適応状態および唾液α-アミラーゼ活性値との関連について Journal of the Japanese Society for Disability and Oral Health 障害者歯科 0913-1663 37 4 401 406 20161031 10.14958/jjsdh.37.401 read0046140/published_papers/14797273 Yukiko Kori 郡由紀子 Kimiko Ueda Yamaguchi 上田(山口) 公子 Hiroshi Nakagawa 中川弘 Tsutomu Iwamoto 岩本勉広汎性発達障害児者の歯科受診適応性評価の試み Aims:To establish a simple method of evaluating the dental treatment adaptability of patients with PDD.Methods:We created a dental treatment adaptability evaluation table consisting of 26 items in 8 categories and asked patients' parents to answer the questionnaire. Sixteen patients (12 males and 4 females, 6-19 years old) participated in this study and were divided into two groups depending on the state of their dental treatment adaptability. The first group consisted of patients who were emotionally compromised and the second group consisted of patients requiring special treatment. Then, we compared the two groups on the evaluation items. Statistical analyses were conducted using Mann-Whitney's U test.Results:1. Regarding age, there was no significant difference between the two groups. 2. For the two categories of cognitive ability and sensitivity, there was a significant difference between the two groups at p<0.01. 3. For the two items of taste and hearing, there was a significant difference between the two groups at p<0.05.Conclusions:The patients requiring special treatment were strongly correlated with the categories of "low cognitive ability" and "high sensitivity" in this questionnaire, suggesting that these categories are important for the dental treatment of patients with PDD. Our questionnaire could be a useful and simple method of evaluating the dental treatment adaptability of patients with PDD. 歯科受診に困難を伴うことの多い高機能の広汎性発達障害(PDD)児者に対して，歯科受診の適応性を迅速かつ簡便に把握するために，「歯科受診適応性評価表」を作成した．「歯科受診適応性評価表」は8つの大項目(1．年齢，2．歯科治療経験の有無，3．初めての場面の受け入れ，4．言語能力・認知能力，5．コミュニケーション能力，6．感覚過敏性，7．こだわり・切り替え，8．衝動性・多動性)について，2∼8つの質問項目で構成されている．PDDを有する患者16名(男性12名，女性4名，年齢6∼19歳，平均年齢10歳5カ月)を対象として，「歯科受診適応性評価表」の各項目について保護者から回答を得た．回答時の歯科受診に対する適応状況から，対象者を「良好群」と「困難群」の2群に分け，各項目について比較検討した．その結果，「言語能力，認知能力」に関する項目と「感覚過敏性」に関する項目について，「良好群」は言語能力，認知能力が高く，「困難群」は感覚過敏性が高い結果となった．さらに「感覚過敏性」に関する項目のうち，味覚と聴覚について，「困難群」では特定の味覚を好み，決まったものしか食べない者が多く，大きな音や特定の音を嫌う者が多かった．以上の結果から，言語，認知能力が低く，感覚過敏性の高いPDD児者は，歯科受診への適応性が低い傾向にあることが示唆され，「歯科受診適応性評価表」はPDD児者の歯科受診適応性を簡便に評価するのに有用である可能性が示された． The Japanese Society for Disability and Oral Health 一般社団法人日本障害者歯科学会 Journal of the Japanese Society for Disability and Oral Health 障害者歯科 0913-1663 37 2 186 191 20160630 10.14958/jjsdh.37.186 read0046140/published_papers/14797275 Yuki Akazawa Tomokazu Hasegawa Yoshitaka Yoshimura Naoyuki Chosa Takeyoshi Asakawa Kimiko Ueda Asuna Sugimoto Takamasa Kitamura Hiroshi Nakagawa Akira Ishisaki Tsutomu Iwamoto Recruitment of mesenchymal stem cells by stromal cell-derived factor 1α in pulp cells from deciduous teeth Spandidos Publications International Journal of Molecular Medicine 1791-244X 36 2 442 448 20150801 10.3892/ijmm.2015.2247 26082290 2-s2.0-84934271560 read0046140/published_papers/14797274 Aimi Yamamoto 山本愛美 Hiroshi Nakagawa 中川弘 Yukiko Kori 郡由紀子 Takamasa Kitamura 北村尚正 Asuna Sugimoto 杉本明日菜 Tsutomu Iwamoto 岩本勉 Disaster Prevention for Children and Adults with Disabilities 災害時要援護者である小児および障碍児・者を持つ保護者の防災意識に関する調査 The Japanese Journal of Pediatric Dentistry 小児歯科学雑誌 0583-1199 53 3 373 382 20150625 10.11411/jspd.53.3_373 read0046140/published_papers/14797276 Hiroshi Nakagawa Akio Hiura QX-314 Induces Analgesia to Nociceptive Thermal Stimulus by Co-Application with Capsiate or Anandamide Austin Biomarkers & Diagnosis 2378-9867 1 1 1 4 20141014 read0046140/published_papers/14797277 Yukihiro Momota 桃田幸弘 Hideyuki Takano 高野栄之 Kohichi Kani 可児耕一 Kazumi Takaishi 高石和美 Hiroshi Nakagawa 中川弘 Shigemasa Tomioka 富岡重正 Yukiko Kori 郡由紀子橋本俊顕 Hiroshi Kitahata 北畑洋 Masayuki Azuma 東雅之いわゆる病病連携による障害者歯科医療連携が奏功した集学的歯科治療について Shikoku Dental Research 四国歯学会雑誌 0914-6091 26 2 35 40 20140200 read0046140/published_papers/14797279 Tomokazu Hasegawa 長谷川智一 Yuki Akazawa 赤澤友基 Hirokazu Nagai 永井宏和 Takamasa Kitamura 北村尚正 Naozumi Ishimaru 石丸直澄 Kimiko Ueda Yamaguchi 上田(山口) 公子 Hiroshi Nakagawa 中川弘 Yukiko Kori 郡由紀子 Aimi Yamamoto 山本愛美 Tsutomu Iwamoto 岩本勉 Capillary Hemangioma on Palate of Infant:Case Report 幼児期の小児の口蓋に発生した血管腫の1例 A hemangioma frequently occurs on the tongue, lip, buccal mucosa, and gingiva in the oral region,though it relatively rarely seen on the palate. We report a case of capillary hemangioma found on the palate of a 2-year-10-month-old boy. He was referred to our department with the chief complaint of a tumor on the palate and a hemangioma was noted on the palatal side of the upper deciduous incisors.We performed surgical resection and the mass was extirpated. The postoperative course was uneventful. Although there was no evidence of recurrence at 6 months after surgery, careful follow-up examinations will be necessary until the upper permanent incisors erupt. 血管腫は血管の増殖を特徴とする良性腫瘍であり，小児の顎口腔領域における良性腫瘍のなかでは比較的多く，軟組織腫瘍の中で最も多い．顎口腔領域に発生する本腫瘍は舌，口唇，歯肉，頬粘膜に好発し，口蓋に発生することは稀である．今回，われわれは，2 歳10 か月男児の口蓋に発生した血管腫を経験したので，その概要を報告する．患児は初診の約4 か月前に下顎部を打撲したため近医歯科を受診した．その際，上顎両側乳中切歯口蓋側歯肉の腫瘤を指摘され，単純性歯肉炎の診断下にプラークコントロールを受けていたが改善しないため当科を紹介された．初診時，切歯乳頭から上顎両側乳中切歯口蓋側歯肉にかけて大きさ10×8×5mm類円形で境界明瞭，暗赤色，表面不整，弾性軟の腫瘤を認め，上顎腫瘍と診断した．局所麻酔下に腫瘍切除術を施行した．病理組織学的診断は毛細血管腫であった．今後，再発に注意しながら，少なくとも永久歯交換まで厳重な経過観察が必要と考えられた． Japanese Society of Pediatric Dentistry The Japanese Journal of Pediatric Dentistry 小児歯科学雑誌 0583-1199 52 3 448 453 20140000 10.11411/jspd.52.3_448 read0046140/published_papers/14797278 Yukiko Kori Kimiko Ueda Yamaguchi Aimi Yamamoto Hiroshi Nakagawa Masami Yoshioka Tsutomu Iwamoto Evaluation of dental treatment adaptability for patient with pervasive developmental disorder(PDD) Journal of Disability and Oral Health 1470-8558 15 3 73 73 20140000 read0046140/published_papers/14797280 Hiroshi Nakagawa Akio Hiura Comparison of the transport of QX-314 through TRPA1, TRPM8 and TRPV1 channels (Cited in "Current Neuropharmacology, 12/2013 11(6); Pharmacological Review, 2014 66(3)") It has been demonstrated that N-ethyl-lidocaine (QX-314) can target the transient receptor protein vanilloid 1 (TRPV1) nociceptors when coadministered with capsaicin, resulting in a selective block of the nociceptors. Capsaicin is problematic in therapeutic use because it induces firing of nociceptors. The present study aimed to search for substitutes for capsaicin. We also examined the transportability of QX-314 into nociceptive neurons, through the pores of transient receptor potential ankyrin 1 (TRPA1), transient receptor potential melastatin-8 (TRPM8), and TRPV1. To investigate the effect on TRPA1, injections of a vehicle, allyl isothiocyanate (AITC), QX-314, or AITC/QX-314 were made into the hind paws of rats. The effects of menthol and capsaicin on the opening of TRPM8 and TRPV1 were also examined and compared with the potency of QX-314. To examine inhibition of the antinociceptive effect by capsaicin/ QX-314, capsazepine (50 g/mL; 10 L) was injected 30 minutes prior to capsaicin/QX-314 (10 L) injection. Thermal sensitivity was investigated by the Hargreaves method. 5(6)-carboxyfluorescein (FAM)-conjugated QX-314 was used as a tracer to examine how many and which kind of dorsal root ganglia accumulate this molecule. QX-314-FAM, capsaicin/QX-314-FAM, AITC/QX-314-FAM, and menthol/QX-314-FAM were injected into the paw. Two weeks after injections, dorsal root ganglia were removed and sectioned with a cryostat. The capsaicin/QX-314 group induced longer withdrawal-response latency at 60 to 300 minutes after injection than the control. Both menthol only and menthol/QX-314 injections showed analgesia 10 to 60 minutes after injection. No significant difference was seen between the capsazepine/capsaicin/QX-314 group and the vehicle group. The fluorescence in small- and medium-sized neurons was conspicuous in only the dorsal root ganglia injected with capsaicin/ QX-314-FAM. These results indicate that TRPA1 and TRPM8 are ineffective in the transport of QX-314 compared with TRPV1. Journal of Pain Research 1178-7090 6 223 230 20130318 10.2147/JPR.S41614 23525210 read0046140/published_papers/14797281 Aimi Yamamoto 山本愛美 Hiroshi Nakagawa 中川弘 Effect of Visual Support in Tooth-brushing Instruction to Autistic Patient and Learning Effect by Continuous Support 自閉症患者へのブラッシング指導における視覚支援の効果と継続的支援による学習効果 Journal of the Japanese Society for Disability and Oral Health 障害者歯科 0913-1663 34 1 12 18 20130228 read0046140/published_papers/14797282 Akio Hiura Hiroshi Nakagawa Changes in response behaviors to noxious heat and mechanical stimuli after carrageenan-induced inflammation in mice treated with capsaicin 2 or 15 days after birth The aim of the present study was to investigate thecause of normal response behaviors to noxious heatdespite the marked loss of small neurons in the dorsalroot ganglion (DRG) as a result of neonatal capsaicintreatment. Capsaicin (50 mg/kg) was injectedsubcutaneously (s.c.) into mice on either day P2 orP15; control mice received a vehicle injection. Twentydays after the capsaicin injection, 2% carrageenan (20μL) was injected into the right hind paw of each animal.Twenty-four hours after the carrageenan injection,behavioral tests using noxious heat stimuli (NHS;Hargreaves method) and noxious mechanical stimuli(NMS; von Frey method) were performed using thecontrol and capsaicin-treated mice. Pre-carrageenanmeasurements were used as the baseline values foreach group. After the experiments, the mice wereperfused with a mixture of 4% paraformaldehyde and0.2% picric acid in a 0.1-M phosphate buffer (pH 7.4).The L4 and L5 DRGs were extracted, sectioned usinga cryostat, and immunostained using a TRPV1antibody and reacted with isolectin IB4. The P2capsaicin-injected mice exhibited a marked increase intheir analgesic responses to NHS, compared with boththeir baseline values and the respective control mice.Both the capsaicin-treated and control animalsexhibited significant hyperalgesia in response to NMS.Naturally, the control P15 mice exhibited a shorterresponse time to NHS than their baseline values, whilethe capsaicin-injected P15 mice exhibited increasedalgesia comparable to the baseline values of thecontrol. The capsaicin-injected mice also exhibitedalgesia in response to NMS. The number ofTRPV1-immunoreactive (ir) small neurons decreasedby 90% in the P2 capsaicin-injected mice and 45% inthe P15 capsaicin-injected mice, whereas an increasein IB4-positive neurons was seen in both the P2 andP15 capsaicin-injected mice. In association with thedecrease in larger neurons, the numbers of smallerneurons were increased in both P2 and P15capsaicin-injected mice. TRPV1-ir small neurons areclosely correlated with inflammatory heat painperception, suggesting the enhancement of anunknown acute noxious heat sensor in the presentstudy. The present findings indicate that noxiousmechanical stimuli can be sensed despite thepresence or absence of TRPV1-ir or IB4-positiveneurons. WebmedCentral WebmedCentral NEUROSCIENCES 2046-1690 1 13 20121206 read0046140/published_papers/14797283 Akio Hiura Hiroshi Nakagawa Analysis of DNA extracted from the trigeminal ganglion cells after neonatal capsaicin treatment by agarose gel electrophoresis WebmedCentral TOXICOLOGY 3 9: WMC003708 1 6 20120918 read0046140/published_papers/14797284 Akio Hiura Hiroshi Nakagawa Innervation of TRPV1-, PGP-, and CGRP-immunoreactive nerve fibers in the subepithelial layer of the whole mount preparation of the rat cornea(Cited in "Survey of Opthalmology, 2014; Journal of Chemical Neuroanatomy, 01/2014") The pattern of innervation of capsaicin receptor, TRPV1-(transient receptor protein vanilloid 1), PGP 9.5-(protein gene product, a marker of peripheral nerve fibers)-, and CGRP (calcitonin gene-related peptide)-immunoreactive (IR) nerve fibers was examined by immunohistological staining of whole mount preparations of the adult rat cornea. The outer corneoscleral limbus toward the central cornea in the subepithelial (stromal) layer was richly innervated by a meshwork of PGP- and CGRP-IR nerve fibers. Sparse innervation was observed in the central cornea, presumably owing to insufficient staining. Dense innervation of TRPV1-IR nerve fibers were demonstrated in addition to innervation of PGP- and CGRP-IR nerve fibers, running from the corneoscleral margin to the central cornea. Although the density of TRPV1-IR nerve fibers appeared to gradually diminish, immunostaining of TRPV1-IR nerve fibers was not as clear as that of PGP- and CGRP-IR nerve fibers. The TRPV1-IR nerve fibers appeared to be thinner than the PGP- and CGRP-IR nerve fibers. The TRPV1-IR leash fibers were observed in the basal epithelial layer, presumably ensuring effective corneal reflex, response to noxious stimuli, and repair of cornea injury. Okajimas Folia Anatomica Japonica 1881-1736 89 2 47 50 20120800 10.2535/ofaj.89.47 23117304 read0046140/published_papers/14813813 Hiroshi Nakagawa Akio Hiura Masato Mitome Kazunori Ishimura Nerve fibers that were not stained with the non-specific acetylcholinesterase (NsAchE) method, and TRPV1- and IB4-positive nerve fibers in the rat cornea Journal of Medical Investigation 1343-1420 56 3-4 157 165 20090000 10.2152/jmi.56.157 19763029 2-s2.0-70350028188 read0046140/published_papers/14813815 HIURA A Akio Hiura Hiroshi Nakagawa Induction of corneal lesion and nerve fiber sprouting by neonatal capsaicin application depends on the dose of the drug and survival time after treatment Okajimas Folia Anat Jpn 0030-154X 82 2 57 65 20050000 10.2535/ofaj.82.57 16212277 read0046140/published_papers/14813817 Akio Hiura Hiroshi Nakagawa Capsaicin-resistant, nonspecific acetylcholinesterase (NsAchE) reactive nerve fibers in the rat cornea: A quantitative and developmental study Okajima Foria Anatomica Yaponika Henshubu Okajimas Folia Anatomica Japonica 0030-154X 81 4 75 84 20040000 10.2535/ofaj.81.75 15615030 2-s2.0-13244287843 read0046140/published_papers/14797285 Hiroshi Nakagawa 中川弘 Fumihiro Matsumoto 松本文博 YOSHIHIRO KUBO 久保吉廣 Dental Treatment of Two Siblings with Adult-type Metachromatic Leukodystrophy - A Case Report - 成人型異染性白質ジストロフィーの1同胞例の歯科治療経験日本障害者歯科学会雑誌 0913-1663 24 1 14 18 20030228 read0046140/published_papers/14813764 NAKAGAWA H HIURA A KUBO Y Preliminary Studis on GABA-immunoreactive Neurons in the Rat Trigeminal Ganglion Okajima Folia Anatomica Japonica 0030-154X 80 1 15 21 20030000 10.2535/ofaj.80.15 12858961 read0046140/published_papers/14813775 Cell death of primary afferent nerve cells in neonatal mice treated with capsaicin Cell death of primary offerent nerve cells in neonatal mice treated with capsaicin Anatomical Science International 77, 47-50 null null 20020000 10.1046/j.0022-7722.2002.00004.x read0046140/published_papers/14797286 Fumihiro Matsumoto 松本文博 Hiroshi Nakagawa 中川弘 YOSHIHIRO KUBO 久保吉廣 Eiichi Bando 坂東永一徳島大学歯学部附属病院特殊歯科総合治療部顎口腔機能治療部門における顎関節症の実態調査 Shikoku Dental Research 四国歯学会雑誌 0914-6091 12 2 227 283 20000131 read0046140/published_papers/14813788 再びラット三叉神経節中のGABA陽性neuronの大きさと分布について歯科基礎医学会雑誌 42 5 472 null 20000000 read0046140/published_papers/14813781 中川弘樋浦明夫久保吉廣新生仔期にカプサイシン投与したマウスの侵害熱刺激応答に対する抗NGFとNGFの影響日本薬理学雑誌 0015-5691 116 2 93 100 20000000 10.1254/fpj.116.93 10976461 read0046140/published_papers/14813792 特殊歯科総合治療部を受診した患者の実態調査四国歯学会雑誌 11 2 245 252 19990000 read0046140/published_papers/14813785 A Hiura H Nakagawa Y Koshigae A Yoshizako Y Kubo H Ishizuka Age-related changes in the response to thermal noxious heat and reduction of C-fibers by neonatal treatment with capsaicin SOMATOSENSORY AND MOTOR RESEARCH 0899-0220 16 2 115 121 19990000 10.1080/08990229970555 read0046140/published_papers/14797287 Ken Shimizu 清水謙笠井啓次 Hiroshi Nakagawa 中川弘天野智子 Kenji Arita 有田憲司 Mizuho Nishino 西野瑞穗小手術時の心身の状態把握のための看護アセスメント The Japanese Journal of Pediatric Dentistry 小児歯科学雑誌 0583-1199 36 3 446 452 19980925 10.11411/jspd1963.36.3_446 read0046140/published_papers/14813795 中川弘樋浦明夫石塚寛マウスの腰部後根神経節と後根内有髄神経の生後発達緒方医学化学研究所医学生物学速報会医学と生物学 0019-1604 136 5 129 134 19980000 read0046140/published_papers/14797288 Hiroshi Nakagawa 中川弘 Keiko Harada 原田桂子鎌田浩二宮本幸子 Kenji Arita 有田憲司 Mizuho Nishino 西野瑞穗小児の歯科診療時の協力性に関する研究 The Japanese Journal of Pediatric Dentistry 小児歯科学雑誌 0583-1199 29 2 325 329 19910625 10.11411/jspd1963.29.2_325 read0046140/published_papers/14813808 中川弘原田桂子鎌田浩二宮本幸子有田憲司西野瑞穂 Studies on the Cooperation-Enhancing Approach in Dealing with Children in the Dental Setting 5. Relationship between the Adaptability to Dental Treatment of the Child and the Anxiety of the Mother 小児の歯科診療時の協力性に関する研究第5報母親の不安度と小児の歯科治療に対する適応性との関連 The Japanese Journal of Pediatric Dentistry 小児歯科学雑誌 0583-1199 29 2 325 329 19910000 10.11411/jspd1963.29.2_325 read0046140/published_papers/14813806 中川弘原田桂子鎌田浩二宮本幸子有田憲司西野瑞穂 Studies on the Cooperation-Enhancing Approach in Dealing with Children in the Dental Setting 4. Relationship between the Adaptability to Dental treatment and Beharioral and Emotional Reactions before and during treatment 小児の歯科診療時の協力性に関する研究第4報小児の歯科治療前および治療中の身体行動および情動反応と治療に対する適応性との関連 The Japanese Journal of Pediatric Dentistry 小児歯科学雑誌 0583-1199 28 4 984 995 19900000 10.11411/jspd1963.28.4_984 2134134 read0046140/published_papers/14797289 Yasuyuki Sasaki 佐々木保行 Mizuho Nishino 西野瑞穗 Toshiaki Suzuki 鈴木敏昭 Kenji Arita 有田憲司 Kazuhiko Takanashi 高梨一彦 Keiko Harada 原田桂子 Tae Okamoto 岡本多恵 Hiroshi Nakagawa 中川弘 A Psychological Study on Adjustment of Dental Treatment in Young Children(2) 小児の歯科診療における適応性の心理学的研究(第2報) Naruto University of Education 鳴門教育大学 Research Bulletin of Educational Sciences Naruto University of Education 鳴門教育大学研究紀要(教育科学編) 1343-4403 3 105 116 19880000 read0046140/published_papers/14813801 原田桂子西野瑞穂有田憲司岡本多恵中川弘佐々木保行鈴木敏昭 Studies on the Cooperation-Enhancing Approach in Dealing with Children in the Dental Setting 3. Child Personality and Behavioral Reactions in the Dental setting 小児の歯科診療時の協力性に関する研究第3報小児の人格的要因と歯科診療時の行動との相関性 The Japanese Journal of Pediatric Dentistry 小児歯科学雑誌 0583-1199 25 4 830 839 19870000 10.11411/jspd1963.25.4_830 read0046140/published_papers/14813797 西野瑞穂有田憲司原田桂子岡本多恵中川弘アルバラードグァダルーペ佐々木保行鈴木敏昭 Studies on Cooperation-Enhancing Approach in Dealing with Children in the Dental Setting 1. A detailed Record of Children's Emothional and Behavioral Reactions in the Dental Settings 小児の歯科診療時の協力性に関する研究第1報歯科受診時の小児の行動と情緒安定度 The Japanese Journal of Pediatric Dentistry 小児歯科学雑誌 0583-1199 25 1 100 108 19870000 10.11411/jspd1963.25.1_100 3506288 read0046140/misc/11275497 Kazumi Takaishi 高石和美 Shigeki Fujiwara Joseph Luke 藤原茂樹 Satoru Eguchi 江口覚 Ohtuka Ryo 大塚良 Yuki Akazawa 赤澤友基 Takamasa Kitamura 北村尚正 Kimiko Ueda Yamaguchi 上田(山口) 公子 Hiroshi Nakagawa 中川弘 Kohichi Kani 可児耕一 Keiko Aota 青田桂子 Yukihiro Momota 桃田幸弘 Yoshiko Yamamura 山村佳子 Keiko Kudoh 工藤景子 Go Ohe 大江剛 Tetsuya Tamatani 玉谷哲也 Youji Miyamoto 宮本洋二 Masayuki Azuma 東雅之 Tsutomu Iwamoto 岩本勉 Hiroshi Kitahata 北畑洋 Dental Treatment under General Anesthesia in Tokushima University Hospital - Safety Management of Disabled Patients with Special Needs during Dental Treatment- 当院における全身麻酔下歯科治療について -障害をもつ方へ安全な歯科治療の提供- Journal of Oral Health and Biosciences 2188-7888 31 1 62 67 20180705 read0046140/misc/11275499 Hiroshi Nakagawa Current Status of Care for Patients with Disabilities in Tokushima Prefecture and Future Perspectives Journal of Oral Health and Biosciences 2188-7888 30 1 40 44 20170630 10.20738/johb.30.1_40 read0046140/misc/11275498 Hiroshi Eguchi Akio Hiura Hiroshi Nakagawa Shunji Kusaka Yoshikazu Shimomura Corneal Nerve Fiber Structure, Its Role in Corneal Function, and Its Changes in Corneal Diseases Hindawi Limited BioMed Research International 2314-6141 2017 3242649 3242649 20170000 10.1155/2017/3242649 29238714 2-s2.0-85042164473 read0046140/misc/11275500 Hiroshi Nakagawa Akio Hiura Four Possible Itching Pathways Related to the TRPV1 Channel, Histamine, PAR-2 and Serotonin (Cited in "Fundamental and Clinical Pharmacology, 02/2015") The following four possible pathways for itching sensation have been suggested by recent reports. 1) Histaminergic TRPV1-positive pathway: Although histamine-positive nerve fibers cannot strictly be classified as "itch specific" due to their excitation also by pure algogens (making them itch-selective), the existence of a subpopulation of nociceptors responsible for itching is strongly suggested. Moreover, the TRPV1-expressing neurons have been suggested to be the main sensors and mediators of itching. 2) Histaminergic TRPV1-negative pathway: The scratching behavior caused by itching was not different between capsaicin-pre-treated and vehicle-treated (control) mast cell-rich NC mice. This result suggests the existence of a capsaicin-insensitive (TRPV1-negative) histaminergic pathway. 3) Non-histaminergic PAR-2 pathway: Protease-activated receptor 2 (PAR-2) has been shown to play a role in the itching of atopic dermatitis (AD). The itch evoked by cowhage (a non-histaminergic pruritogen that activates PAR-2) is very similar in characteristics to the itch evoked by conditions such as AD. 4) Non-histaminergic serotonin (5-HT) pathway: 5-HT alone applied to the human skin evokes an itching sensation and has been suggested to be involved in the itching associated with pruritic diseases, such as polycythemia vera and cholestasis. The Malaysian Journal of Medical Sciences : MJMS 1394-195X 20 4 5 12 20130800 24043991 read0046140/misc/11275501 Akio Hiura Hiroshi Nakagawa Participation of Glias and Immune Cells in Neuropathic Pain WebmedCentral 2046-1690 3 9: WMC003728 1 8 20120927 10.9754/journal.wmc.2012.003728 read0046140/misc/11275502 Hiroshi Nakagawa 中川弘 Akio Hiura 樋浦明夫 An Overview of the Actions of Capsaicin and Its Receptor, TRPV1, and Their Relations to Small Primary Sensory Neurons カプサイシンの作用とそのレセプター，TRPV1, 及びそれらと関連する小型一次知覚ニューロンの概観 The specific actions of capsaicin on the small primary afferent neurons with regard to neuogenic inflammation and plasma extravasation are examined in this review. First, a short history of the study of capsaicin is introduced from the viewpoint of the efferent function of capsaicin-sensitive nerve fibers. Agonist (resiniferatoxin) and antagonists (capsazepine and ruthenium red) of capsaicin are refened, to better understand the action of the drug. The significance of the discovery of capsaicin receptor, TRPV1, and its characteristic features (polymodal receptor) are discussed based on recent reports, although the sensitization or desensitization mechanisms are not yet resolved. This review also briefly deals with the therapeutic use of capsaicin and its agonist and antagonist for relief pain. Whether or not capsaicin-sensitive nerve fibers are involved in itching is examined by recent literature survey. TRPV1-expressing nerve fibers were recently reported to be responsible for the itching sensation. Then, we proposed putative three possible itching pathways. The participation of pure sensoty nervefibers which exclusively transmit itchiness has not been found, as yet. 四国歯学会 Shikoku Dental Research 四国歯学会雑誌 0914-6091 25 1 1 10 20120720 read0046140/misc/11275503 Akio Hiura Hiroshi Nakagawa Roles of Glia, immune cells and the thermo-TRP channels, TRPV1, TRPA1 and TRPM8, in pathological pain Open Neuroscience Journal 1874-0820 6 1 10 26 20120000 10.2174/1874082001206010010 2-s2.0-84859509685 read0046140/misc/11275504 Akio Hiura Hiroshi Nakagawa An overview of the action of capsaicin and its receptor , TRPV1, and their relations to small primary sensory neurons (In the Hot-Topic of "Anti-inflammatory and anti-allergy functions of capsaicin in association with its actions on primary sensory neuron Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 1871-5230 10 1 2 9 20110200 10.2174/187152311795325505 read0046140/misc/23174213 Hiroshi Nakagawa 中川弘 Akio Hiura 樋浦明夫カプサイシンとTRP チャネル・サブファミリーおよびカプサイシン受容体 (TRPV1) と小型一次知覚ニューロンの特性とその相関関係 A number of subfamilies of the capsaicin receptor, collectively called TRP, have been reported since the discovery of vanilloid receptor 1 (VR1). The term "TRP" is derived from "transient receptor potential", which means the transient and rapid defect of reaction following long stimulation with light in the photoreceptor cells of mutant Drosophila. The common features of TRP family members are the centrally situated six transmembrane domains, in which an ion channel is located. The TRP family members are present in animals, including invertebrates and vertebrates, and in the cells in various tissues in individual animals. During evolution, the original TRP seems to have acquired a wide variety of functions related to sensing the inner or outer environment (e.g. to sensing light: Drosophila), osmolarity, protons, temperature, ligands and mechanical force). In mammals, the TRP subfamily is exclusively expressed in small- to medium-sized primary sensory neurons that also co-express some chemical markers (i.e. isolectin B4: IB4), fluoride-resistant acid phosphatase (FRAP), the P2X_3 purinoceptor (a receptor provoked by ATP-induced nociception) and Ret, a glial cell-line derived neurotrophic factor receptor). There is a paradox in that regardless of the marked or complete loss of noxious, small sensory neurons (polymodal nociceptors) in mice treated with capsaicin during the neonatal period, as well as in VR1 (TRPV1)-deficient knock-out mice, the responses to noxious heat are normal. Regarding the paradox in mice treated with capsaicin as neonates, our explanation is that although capsaicin probably reduces the number of a subgroup of small neurons (IB4-, VR1+), the remaining IB4+ (VR1-) neurons can sense noxious heat normally. One working hypothesis is that mice lacking TRPV1/2 can sense noxious heat under normal conditions, presumably via another still unknown pathway, and TRPV1 has been suggested to be involved in noxious heat transduction under pathological conditions, such as inflammation and tissue injury. Further studies will be required to clarify these complexities. Mice treated with capsaicin as neonates would provide a model to investigate the above paradoxes, as would TRPV1-knock-out mice, although different mechanisms may be operating in the two models. This article is reproduced from the current review published in the Anatomical Science International (Vol. 81, 2006) under the approvals by the chief editor of ASI and Blackwell Publishing. A number of subfamilies of the capsaicin receptor, collectively called TRP, have been reported since the discovery of vanilloid receptor 1 (VR1). The term TRP is derived from transient receptor potential, which means the transient and rapid defect of reaction following long stimulation with light in the photoreceptor cells of mutant Drosophila. The common features of TRP family members are the centrally situated six transmembrane domains, in which an ion channel is located. The TRP family members are present in animals, including invertebrates and vertebrates, and in the cells in various tissues in individual animals. During evolution, the original TRP seems to have acquired a wide variety of functions related to sensing the inner or outer environment (e.g. to sensing light: Drosophila), osmolarity, protons, temperature, ligands and mechanical force). In mammals, the TRP subfamily is exclusively expressed in small- to medium-sized primary sensory neurons that also co-express some chemical markers (i.e. isolectin B4: IB4), fluoride-resistant acid phosphatase (FRAP), the P2X_3 purinoceptor (a receptor provoked by ATP-induced nociception) and Ret, a glial cell-line derived neurotrophic factor receptor). There is a paradox in that regardless of the marked or complete loss of noxious, small sensory neurons (polymodal nociceptors) in mice treated with capsaicin during the neonatal period, as well as in VR1 (TRPV1)-deficient knock-out mice, the responses to noxious heat are normal. Regarding the paradox in mice treated with capsaicin as neonates, our explanation is that although capsaicin probably reduces the number of a subgroup of small neurons (IB4-, VR1+), the remaining IB4+ (VR1-) neurons can sense noxious heat normally. One working hypothesis is that mice lacking TRPV1/2 can sense noxious heat under normal conditions, presumably via another still unknown pathway, and TRPV1 has been suggested to be involved in noxious heat transduction under pathological conditions, such as inflammation and tissue injury. Further studies will be required to clarify these complexities. Mice treated with capsaicin as neonates would provide a model to investigate the above paradoxes, as would TRPV1-knock-out mice, although different mechanisms may be operating in the two models. This article is reproduced from the current review published in the Anatomical Science International (Vol. 81, 2006) under the approvals by the chief editor of ASI and Blackwell Publishing. The University of Tokushima 徳島大学 Shikoku Dental Research 四国歯学会雑誌 0914-6091 19 2 197 218 20070131 read0046140/misc/23174212 Hiroshi Nakagawa Akio Hiura Capsaicin, transient receptor potential (TRP) protein subfamilies and the particular relationship between capsaicin receptors and small primary sensory neurons ANATOMICAL SCIENCE INTERNATIONAL 1447-6959 81 3 135 155 20060900 10.1111/j.1447-073x.2006.00141.x 16955665 read0046140/misc/23174209 Quantitative study on the number and size of GAB-immunoreactive neurons in the rat trigeminal ganglion Japanese Journal of Oral Biology 42 5 472 null 20000000 read0046140/misc/23174208 H. Nakagawa A. Hiura Y. Kubo The effect of anti-NGF and NGF on the responses to noxious heat in mice treated with capsaicin in the neonatal period Japanese Pharmacological Society Folia Pharmacologica Japonica 0015-5691 116 2 93 100 20000000 10.1254/fpj.116.93 10976461 2-s2.0-0033827223 read0046140/misc/23174210 Survey of patients at the Center for Special Care in Dentistry, Tokushima University Dental Hospiatl Shikoku Society of Dental Research 11 2 245 252 19990000 read0046140/misc/23174211 Postnatal maturation of lumbar dorsal root ganglion cells and myelinated fibers in the dorsal root of the mouse. MEDICINE AND BIOLOGY 136 5 129 134 19980000 read0046140/presentations/397225 Kokoro Iwata 岩田こころ Asuna Sugimoto 杉本明日菜 Rika Kurogohshi 黒厚子璃佳 Keita Kawarabayashi 河原林啓太 Aya Miyazaki 宮嵜彩藤島史帆 Takamasa Kitamura 北村尚正 Yuki Akazawa 赤澤友基 Rie Niji 尼寺理恵 Kimiko Ueda Yamaguchi 上田(山口) 公子 Hiroshi Nakagawa 中川弘 Tomokazu Hasegawa 長谷川智一 Tsutomu Iwamoto 岩本勉当科における初診患者の実態調査~平成における30年間の変遷~ 第37回日本小児歯科学会中四国地方会大会 20181104 read0046140/presentations/397224 黒厚子璃佳 Asuna Sugimoto 杉本明日菜 Kokoro Iwata 岩田こころ Aya Miyazaki 宮嵜彩 Keita Kawarabayashi 河原林啓太藤島史帆 Yuki Akazawa 赤澤友基 Takamasa Kitamura 北村尚正 Kimiko Ueda Yamaguchi 上田(山口) 公子 Rie Niji 尼寺理恵 Tomokazu Hasegawa 長谷川智一 Hiroshi Nakagawa 中川弘 Tsutomu Iwamoto 岩本勉当科における5年間の障害児の初診時実態調査第37回日本小児歯科学会中四国地方会大会 20181104 read0046140/presentations/397223 Asuna Sugimoto 杉本明日菜 Aya Miyazaki 宮嵜彩 Keita Kawarabayashi 河原林啓太 Kokoro Iwata 岩田こころ Rika Kurogohshi 黒厚子璃佳 Yuki Akazawa 赤澤友基 Tomokazu Hasegawa 長谷川智一 Kimiko Ueda Yamaguchi 上田(山口) 公子 Takamasa Kitamura 北村尚正 Hiroshi Nakagawa 中川弘 Tsutomu Iwamoto 岩本勉象牙芽細胞におけるピエゾ型イオンチャネル1(PIEZO1)の発現とその役割第37回日本小児歯科学会中四国地方会大会 20181104 read0046140/presentations/397226 Hiroshi Nakagawa 中川弘 Kimiko Ueda Yamaguchi 上田(山口) 公子 Takamasa Kitamura 北村尚正 Aya Miyazaki 宮嵜彩 Tsutomu Iwamoto 岩本勉 Development of the new molecular target therapy for wound healing of oral mucosa : p-HPPH promotes cell migration in human gingival fibroblasts p-HPPHを分子標的とした新規口腔粘膜創傷治癒促進薬の開発ー歯肉線維芽細胞におけるp-HPPHによる細胞遊走の促進作用についてー Journal of the Japanese Society for Disability and Oral Health 障害者歯科 20171028 read0046140/presentations/397227 Kimiko Ueda Yamaguchi 上田(山口) 公子 Yuki Akazawa 赤澤友基 Takamasa Kitamura 北村尚正杉本明日菜 Tomokazu Hasegawa 長谷川智一 Hiroshi Nakagawa 中川弘 Tsutomu Iwamoto 岩本勉ヒト歯肉線維芽細胞におけるS-PRGフィラー抽出液による細胞遊走の促進 The Japanese Journal of Pediatric Dentistry 小児歯科学雑誌 20151004 read0046140/presentations/397229 Aimi Yamamoto 山本愛美 Hiroshi Nakagawa 中川弘 Yukiko Kori 郡由紀子 Takamasa Kitamura 北村尚正杉本明日菜 Tsutomu Iwamoto 岩本勉小児および障碍児・者への防災意識に関する研究 The Japanese Journal of Pediatric Dentistry 小児歯科学雑誌 20150521 read0046140/presentations/397228 Kimiko Ueda Yamaguchi 上田(山口) 公子益富由佳子 Rie Niji 尼寺理恵 Takamasa Kitamura 北村尚正 Aimi Yamamoto 山本愛美 Yuki Akazawa 赤澤友基杉本明日菜白石真紀 Hiroshi Nakagawa 中川弘 Tomokazu Hasegawa 長谷川智一 Yukiko Kori 郡由紀子 Tsutomu Iwamoto 岩本勉 Clinical survey of traumatic dental injuries in children at our outpatient clinic 当科における小児の乳歯と永久歯の外傷の実態調査 The Japanese Journal of Pediatric Dentistry 小児歯科学雑誌 20150521 read0046140/presentations/397230 Tomokazu Hasegawa 長谷川智一 Yuki Akazawa 赤澤友基吉村善隆帖佐直幸浅川剛吉杉本明日菜 Takamasa Kitamura 北村尚正 Kimiko Ueda Yamaguchi 上田(山口) 公子 Hiroshi Nakagawa 中川弘白石真紀石崎明 Tsutomu Iwamoto 岩本勉乳歯歯根膜由来細胞のSDF-1αを介した歯周組織恒常性に関わる細胞間相互作用 The Japanese Journal of Pediatric Dentistry 小児歯科学雑誌 20150000 read0046140/presentations/397231 Kimiko Ueda Yamaguchi 上田(山口) 公子 Yukiko Kori 郡由紀子 Hiroshi Nakagawa 中川弘 Aimi Yamamoto 山本愛美 Rie Niji 尼寺理恵真杉幸江 Tsutomu Iwamoto 岩本勉広汎性発達障害児・者の歯科受診適応性と唾液アミラーゼ活性値を指標としたストレス評価障害者歯科 20141003 read0046140/presentations/397220 Yukiko Kori Kimiko Ueda Yamaguchi Aimi Yamamoto Hiroshi Nakagawa Masami Yoshioka Tsutomu Iwamoto Evaluation of dental treatment adaptability for patient with pervasive developmental disorder(PDD) 22nd Congress of the International Association of Disability and Oral Health 20141003 read0046140/presentations/397236 Tomokazu Hasegawa 長谷川智一赤澤友基 Hiroshi Nakagawa 中川弘上田公子 Tsutomu Iwamoto 岩本勉乳歯歯髄細胞による細胞走化性因子の調節機構 The Japanese Journal of Pediatric Dentistry 小児歯科学雑誌 20140000 read0046140/presentations/397235 Tomokazu Hasegawa 長谷川智一赤澤友基 Takamasa Kitamura 北村尚正 Kimiko Ueda Yamaguchi 上田(山口) 公子 Hiroshi Nakagawa 中川弘 Tsutomu Iwamoto 岩本勉幼児期の小児の口蓋に発生した血管腫の1例 The Japanese Journal of Pediatric Dentistry 小児歯科学雑誌 20140000 read0046140/presentations/397234 赤澤友基 Tomokazu Hasegawa 長谷川智一久保-藤原百合 Takamasa Kitamura 北村尚正 Kimiko Ueda Yamaguchi 上田(山口) 公子 Hiroshi Nakagawa 中川弘 Tsutomu Iwamoto 岩本勉当科にて長期的口腔内管理を行った伊藤白斑の1例 The Japanese Journal of Pediatric Dentistry 小児歯科学雑誌 20140000 read0046140/presentations/397233 Hiroshi Nakagawa 中川弘 Aimi Yamamoto 山本愛美 Yuki Akazawa 赤澤友基 Takamasa Kitamura 北村尚正 Tomokazu Hasegawa 長谷川智一 Tsutomu Iwamoto 岩本勉 p-HPPHを分子標的としたフェニトインによる歯肉増殖症に対する新規治療薬の開発 Journal of the Japanese Society for Disability and Oral Health 障害者歯科 20140000 read0046140/presentations/397232 Takamasa Kitamura 北村尚正 Hiroshi Nakagawa 中川弘杉本明日菜 Yuki Akazawa 赤澤友基 Tomokazu Hasegawa 長谷川智一 Tsutomu Iwamoto 岩本勉含歯性嚢胞の間葉系結合組織層が骨吸収に与える影響歯基礎誌抄録 20140000 read0046140/presentations/397237 Kimiko Ueda Yamaguchi 上田(山口) 公子 Aimi Yamamoto 山本愛美 Yukiko Kori 郡由紀子 Hiroshi Nakagawa 中川弘 Tomokazu Hasegawa 長谷川智一 Tsutomu Iwamoto 岩本勉上顎中切歯の萌出遅延を起こした集合性歯牙腫の1症例第32回日本小児歯科学会中四国地方会大会 20131124 read0046140/presentations/397238 Kimiko Ueda Yamaguchi 上田(山口) 公子 Yukiko Kori 郡由紀子 Aimi Yamamoto 山本愛美赤澤友基 Takamasa Kitamura 北村尚正 Hiroshi Nakagawa 中川弘 Tomokazu Hasegawa 長谷川智一 Tsutomu Iwamoto 岩本勉過剰歯摘出によって歯の位置異常が改善した症例についての検討第31回日本小児歯科学会北日本地方会大会 20131026 read0046140/presentations/397239 Hiroshi Nakagawa 中川弘 Aimi Yamamoto 山本愛美 Yukiko Kori 郡由紀子 Kimiko Ueda Yamaguchi 上田(山口) 公子赤澤友基 Takamasa Kitamura 北村尚正 Tomokazu Hasegawa 長谷川智一 Tsutomu Iwamoto 岩本勉 The longitudinal changes in the results of psychological tests applied to a patient with dental phobia 歯科治療恐怖症患者に応用した心理検査結果の経時的変化について Journal of the Japanese Society for Disability and Oral Health 障害者歯科 20131013 read0046140/presentations/397240 Aimi Yamamoto 山本愛美有田憲司 Yukiko Kori 郡由紀子 Kimiko Ueda Yamaguchi 上田(山口) 公子 Hiroshi Nakagawa 中川弘 Tsutomu Iwamoto 岩本勉当院小児摂食外来を受診した初診患児の実態調査第30回日本障害者歯科学会学術大会 20131012 read0046140/presentations/397241 Aimi Yamamoto 山本愛美有田憲司 Yukiko Kori 郡由紀子 Kimiko Ueda Yamaguchi 上田(山口) 公子 Hiroshi Nakagawa 中川弘 Tsutomu Iwamoto 岩本勉当院小児摂食外来を受診した初診患児の実態調査 Journal of the Japanese Society for Disability and Oral Health 障害者歯科 20130901 read0046140/presentations/397243 Hiroshi Nakagawa 中川弘 Aimi Yamamoto 山本愛美 Yukiko Kori 郡由紀子赤澤友基 Takamasa Kitamura 北村尚正 Tomokazu Hasegawa 長谷川智一 Tsutomu Iwamoto 岩本勉歯科治療恐怖症患者に応用した心理検査結果の経時的変化について Journal of the Japanese Society for Disability and Oral Health 障害者歯科 20130000 read0046140/presentations/397242 上田公子 Aimi Yamamoto 山本愛美 Yukiko Kori 郡由紀子 Hiroshi Nakagawa 中川弘 Tomokazu Hasegawa 長谷川智一 Tsutomu Iwamoto 岩本勉上顎中切歯の萌出遅延を起こした集合性歯牙腫の1症例 The Japanese Journal of Pediatric Dentistry 小児歯科学雑誌 20130000 read0046140/presentations/397248 Akio Hiura 樋浦明夫 Hiroshi Nakagawa 中川弘 QX-314 はカプシエイトまたはアナンドアミドとの併用投与で侵害熱刺激を抑制する平成24年度生理学研究所研究会「痛み研究の新たな展開」(岡崎) 20121213 read0046140/presentations/397244 Rie Niji 尼寺理恵 Yukiko Kori 郡由紀子 Hiroshi Nakagawa 中川弘 Aimi Yamamoto 山本愛美障害者施設での実習前後における学生の意識変化 Journal of the Japanese Society for Disability and Oral Health 障害者歯科 20120929 read0046140/presentations/397221 Akio Hiura Hiroshi Nakagawa Paradoxical behaviors in response to nociceptive stimuli after inflammation in mice pretreated with capsaicin at neonate. 8th FENS FOrum of Neuroscience, Barcelona, July, 2012 8th FENS Forum of Neuroscience 20120716 read0046140/presentations/397245 Hiroshi Nakagawa 中川弘 Aimi Yamamoto 山本愛美 Rie Niji 尼寺理恵 Yukiko Kori 郡由紀子 Development of a new local anesthetic by use of TRP channel ; Comparizon with TRPV1 and 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