type: misc

label: url

en: 特集 Sjögren症候群の最近の知見 総説2 Sjögren症候群の病理

ja: 特集 Sjögren症候群の最近の知見 総説2 Sjögren症候群の病理

en: Practical Dermatology

ja: 皮膚病診療


en: Dd診断力てすと 歯肉と頬粘膜の白色病変

ja: Dd診断力てすと 歯肉と頬粘膜の白色病変

en: デンタルダイアモンド

ja: デンタルダイアモンド


en: Role of α-Fodrin Autoantigen in Sjogren's Syndrome

ja: シェーグレン症候群における自己抗原α-Fodrinの役割 (武田憲昭教授退任記念総説集)

ja: 耳鼻咽喉科臨床 補冊


en: A role of follicular helper T cell in the pathogenesis of Sjogren's syndrome

ja: シェーグレン症候群における濾胞ヘルパーT細胞の役割 (特集 濾胞ヘルパーT細胞と疾患)

en: Clinical Immunology & Allergology

ja: 臨床免疫·アレルギー科


en: Invasion-Related Factors as Potential Diagnostic and Therapeutic Targets in Oral Squamous Cell Carcinoma-A Review.

en: It is well recognized that the presence of cervical lymph node metastasis is the most important prognostic factor in oral squamous cell carcinoma (OSCC). In solid epithelial cancer, the first step during the process of metastasis is the invasion of cancer cells into the underlying stroma, breaching the basement membrane (BM)-the natural barrier between epithelium and the underlying extracellular matrix (ECM). The ability to invade and metastasize is a key hallmark of cancer progression, and the most complicated and least understood. These topics continue to be very active fields of cancer research. A number of processes, factors, and signaling pathways are involved in regulating invasion and metastasis. However, appropriate clinical trials for anti-cancer drugs targeting the invasion of OSCC are incomplete. In this review, we summarize the recent progress on invasion-related factors and emerging molecular determinants which can be used as potential for diagnostic and therapeutic targets in OSCC.

en: International Journal of Molecular Sciences


en: Aurora Kinase Inhibitors In Head And Neck Cancer.

en: Aurora kinases are a group of serine/threonine kinases responsible for the regulation of mitosis. In recent years, with the increase in Aurora kinase-related research, the important role of Aurora kinases in tumorigenesis has been gradually recognized. Aurora kinases have been regarded as a new target for cancer therapy, resulting in the development of Aurora kinase inhibitors. The study and application of these small-molecule inhibitors, especially in combination with chemotherapy drugs, represents a new direction in cancer treatment. This paper reviews studies on Aurora kinases from recent years, including studies of their biological function, their relationship with tumor progression, and their inhibitors.

en: Current Topics in Medicinal Chemistry

ja: Current Topics in Medicinal Chemistry


en: Unique Phenotypes and Functions of Follicular Helper T Cell and Regulatory T Cell in Sjögren's Syndrome.

en: Sjögren's syndrome (SS) is a T cell-mediated autoimmune disease of the systemic exocrine glands, such as salivary and lacrimal glands. A variety of T-cell subpopulations maintain immune tolerance in the thymus and periphery through complex immune responses including cellular and humoral immunity. The T-cell subpopulations exhibiting abnormal or unique phenotypes and impaired functionality have been reported to play important roles in the cellular mechanisms of autoimmunity in SS patients and animal models of SS. In this review, we focused on follicular helper T cells related to antibody production and regulatory T cells to control immune tolerance in the pathogenesis of SS. The unique roles of these T-cell subpopulations in the process of the onset or development of SS have been demonstrated in this review of recent publications. The clinical application of these T-cell subpopulations will be helpful for the development of new techniques for diagnosis or treatment of SS in the future.

en: Current Rheumatology Reviews

ja: Current Rheumatology Reviews


en: Oral environment and cancer

ja: Oral environment and cancer

en: Cancer is now the leading cause of death in Japan. A rapid increase in cancer mortality is expected as Japan is facing a super-aged society. Many causes of cancer are known to be closely linked to life style factors, such as smoking, drinking, and diet. The oral environment is known to be involved in the pathogenesis and development of various diseases such as bronchitis, pneumonia, diabetes, heart disease, and dementia. Because the oral cavity acts as the bodily entrance for air and food, it is constantly exposed to foreign substances, including bacteria and viruses. A large number of bacteria are endemic to the oral cavity, and indigenous oral flora act to prevent the settlement of foreign bacteria. The oral environment is influenced by local factors, including dental plaque, tartar, teeth alignment, occlusion, an incompatible prosthesis, and bad lifestyle habits, and systemic factors, including smoking, consumption of alcohol, irregular lifestyle and eating habits, obesity, stress, hormones, and heredity. It has recently been revealed that the oral environment is associated with cancer. In particular, commensal bacteria in the oral cavity are involved in the development of cancer. Moreover, Candida, human papilloma virus and Epstein-Barr virus as well as commensal bacteria have been reported to be associated with the pathogenesis of cancer. In this review, we introduce recent findings of the correlation between the oral environment and cancer.

en: Genes and Environment

ja: Genes and Environment


en: Role of regulatory T cell in the pathogenesis of inflammatory bowel disease.

en: Regulatory T (Treg) cells play key roles in various immune responses. For example, Treg cells contribute to the complex pathogenesis of inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis during onset or development of that disease. Many animal models of IBD have been used to investigate factors such as pathogenic cytokines, pathogenic bacteria, and T-cell functions, including those of Treg cells. In addition, analyses of patients with IBD facilitate our understanding of the precise mechanism of IBD. This review article focuses on the role of Treg cells and outlines the pathogenesis and therapeutic strategies of IBD based on previous reports.

en: World Journal of Gastroenterology : WJG

ja: World Journal of Gastroenterology : WJG


en: Mechanism of Activation-Induced Cell Death of T Cells and Regulation of FasL Expression.

en: Activation-induced cell death (AICD) of T cells is a process for regulating the peripheral immune system. The fate of a T cell is controlled by numerous signals derived from various stimuli, such as antigens, cytokines, and chemokines. In healthy humans, overactivated or autoreactive T cells are harmful and are eliminated to maintain the immune system. AICD in T cells by Fas/FasL-mediated apoptosis is triggered by the switch from life to death through several signaling molecules. The control or distribution of Fas or FasL expression largely affects AICD of T cells. Although autoimmune diseases are considered to be induced by multiple factors, an impaired immune system with AICD by Fas/FasL-mediated apoptosis leads to the onset or development of autoimmunity. Based on published reports, this review describes the regulatory mechanisms involved in AICD of T cells by Fas/ FasL-mediated apoptosis and the associations between AICD and autoimmunity in humans and animal models.

en: Critical Reviews in Immunology

ja: Critical Reviews in Immunology


en: Matrix metalloproteinases: the gene expression signatures of head and neck cancer progression.

en: Extracellular matrix degradation by matrix metalloproteinases (MMPs) plays a pivotal role in cancer progression by promoting motility, invasion and angiogenesis. Studies have shown that MMP expression is increased in head and neck squamous cell carcinomas (HNSCCs), one of the most common cancers in the world, and contributes to poor outcome. In this review, we examine the expression pattern of MMPs in HNSCC by microarray datasets and summarize the current knowledge of MMPs, specifically MMP-1, -3, -7 -10, -12, -13, 14 and -19, that are highly expressed in HNSCCs and involved cancer invasion and angiogenesis.

en: Cancers

ja: Cancers


en: Targeting IL-1 in Sjögren's syndrome.

ja: Targeting IL-1 in Sjögren's syndrome.

en: Introduction: IL-1 plays key roles in the biological functions of various cells. In particular, many roles of IL-1 in the immune system have been discovered by numerous studies. This review focuses on the association of IL-1 with the pathogenesis of autoimmunity. Areas covered: An overview of the biological functions of the IL-1 family and the IL-1 receptors (IL-1Rs), including the maintenance of systemic or local homeostasis, and the signaling pathway through IL-1/IL-1R in various immune systems are described. Several functions of IL-1 in the pathogenesis of Sjögren's syndrome (SS) have been demonstrated with a focus on the immune responses and target tissues in SS. In addition to the role of IL-1 in the immune responses in SS, the function of IL-1 in ocular mucosa lesions in SS has been described. Lastly, there is an overview of possible therapeutic strategies for IL-1 inhibition in SS. Expert opinion: IL-1 plays critical roles in the onset and development of SS by controlling systemic or local immune responses and maintaining the survival and mucosal defense of target epithelial cells. The inhibition of the pathogenic functions of IL-1 may be beneficial for treating SS.

en: Expert Opinion on Therapeutic Targets

ja: Expert Opinion on Therapeutic Targets


en: Sjogren's syndrome

ja: Sjogren症候群

en: Sjögren症候群はドライアイやドライマウスを臨床症状とする原因不明の自己免疫疾患である．病因的アプローチを加えるため疾患モデルを開発し，ヒトとも共通する自己抗原120kDα-フォドリンを同定した．局所に浸潤するCD4陽性T細胞の多くがFasLを発現し，標的細胞のFas抗原との間でアポトーシスが成立している．また，唾液腺にエストロゲン欠乏依存性にアポトーシスを誘導するRbAp48遺伝子を同定した．

en: The Journal of the Japanese Society of Internal Medicine

ja: 日本内科学会雑誌


en: Regulation of immune response by RANKL and Fas

ja: RANKLとFasによる免疫応答の制御

en: Clinical Immunology & Allergology


en: Immunotherapeutic targets in estrogen deficiency-dependent Sjögren's syndrome-related manifestations

en: Although a number of autoimmune diseases are known to develop in postmenopausal women, the mechanisms by which estrogen deficiency influences autoimmunity remain unclear. Previously, we found that tissue-specific apoptosis in the exocrine glands in estrogen-deficient mice may contribute to the development of autoimmune exocrinopathy. We found that RbAp48 overexpression induces p53-mediated apoptosis in the exocrine glands depending on estrogen deficiency. RbAp48-inducible transfectants result in rapid apoptosis with p53 phosphorylation (Ser9), and alpha-fodrin cleavage. Indeed, transgenic expression of the RbAp48 gene induced apoptosis in the exocrine glands, resulting in the development of autoimmune exocrinopathy resembling Sjögren's syndrome (SS). CD4(+) T-cell-mediated autoimmune lesions were aggravated with age, in association with production of autoantibodies against SS-A, SS-B and alpha-fodrin. These findings demonstrated that estrogen deficiency initiates tissue-specific apoptosis in the exocrine gland cells through RbAp48 overexpression and exerts a possible gender-based risk of autoimmune exocrinopathy in postmenopausal women. Thus, these data indicate RbAp48 to be a novel immunotherapeutic target for preventing epithelial cell apoptosis and the development of gender-based autoimmune exocrinopathy.

en: Immunotherapy

ja: Immunotherapy


en: Crosstalk between RANKL and Fas signaling in dendritic cells controls immune tolerance

ja: RANKLとFasシグナルクロストークによる樹状細胞の機能調節機構


en: NF-kB2によるT細胞の新たな調節機構

ja: NF-kB2によるT細胞の新たな調節機構

en: Experimental Medicine

ja: 実験医学


en: Crucial Roles of NF-κB for T Cell Activation

en: Journal of Oral Biosciences

ja: Journal of Oral Biosciences


en: エストロゲンと自己免疫疾患

ja: エストロゲンと自己免疫疾患

en: Annual Review糖尿病・代謝・内分泌2006

ja: Annual Review糖尿病・代謝・内分泌2006


en: Crucial Role of Tissue-Specific Apoptosis on the Development of Primary Sjogren's Syndrome

en: Oral Science International

ja: Oral Science International


en: Apoptosis and Estrogen Deficiency in Primary Sjögren Syndrome

en: Primary Sjögren syndrome is an autoimmune disorder characterized by lymphocytic infiltrates and destruction of the salivary and lacrimal glands, and systemic production of autoantibodies to the ribonucleoprotein particles SS-A/Ro and SS-B/La. The purpose of this review is to discuss recent advances in the pathogenesis of primary Sjögren syndrome. Although several candidate autoantigens including alpha-fodrin have been reported in Sjögren syndrome, the pathogenic roles of the autoantigens in initiation and progression of SS are still unclear. It is possible that individual T cells activated by an appropriate self antigen can proliferate and form a restricted clone. Recent evidence suggests that the apoptotic pathway plays a central role in tolerizing T cells to tissue-specific self antigen, and may drive the autoimmune phenomenon. Cleavage of certain autoantigens during apoptosis may reveal immunocryptic epitopes that could potentially induce autoimmune response. The studies reviewed imply that Fas-mediated cytotoxicity and caspase-mediated alpha-fodrin proteolysis are involved in the progression of tissue destruction in Sjögren syndrome. Fas ligand (FasL), and its receptor Fas are essential in the homeostasis of the peripheral immune system. It can be considered that a defect in activation-induced cell death of effector T cells may result in the development of autoimmune exocrinopathy in Sjögren syndrome. Although the mechanisms by which estrogen deficiency influences autoimmune lesions remain unclear, it is possible that antiestrogenic actions might be a potent factor in the formation of pathogenic autoantigens.

en: Current Opinion in Rheumatology

ja: Current Opinion in Rheumatology


en: Aging and Autoimmune Diseases

ja: 老化と自己免疫疾患

en: 日本アフェレシス学会雑誌

ja: 日本アフェレシス学会雑誌


en: 自己免疫疾患の発症とアポトーシス

ja: 自己免疫疾患の発症とアポトーシス

en: The Cell

ja: 細胞


en: The role of caspase cascade on the development of primary Sjogren's syndrome

en: Primary Sjögren syndrome (SS) is an autoimmune disease characterized by diffuse lymphoid cell infiltrates in the salivary and lacrimal glands, resulting in symptoms of dry eye and dry mouth due to insufficient secretion. Previously, we have identified the 120 kDa alpha-fodrin as an important autoantigen on the development of SS in both animal model and SS patients, but the mechanism of a -fodrin cleavage leading to tissue destruction in SS remains unclear. In murine primary SS model, tissue-infiltrating CD4+ T cells purified from the salivary glands bear a large proportion of Fas ligand (FasL), and the salivary gland duct cells constitutively possess Fas. Infiltrating CD4+ T cells identified significant 51Cr release against mouse salivary gland (MSG) cells. In vitro studies demonstrated that apoptotic MSG cells result in a specific alpha-fodrin cleavage into 120 kDa, and preincubation with caspase-inhibitor peptides blocked alpha-fodrin cleavage. The treatment with caspase-inhibitors in vivo prevented the development of autoimmune lesions in the salivary and lacrimal glands. Thus, an increased activity in caspase cascade may be involved in the progression of alpha-fodrin proteolysis and tissue destruction on the development of SS.

en: The Journal of Medical Investigation : JMI


en: シェーグレン症候群発症の分子機構

ja: シェーグレン症候群発症の分子機構

en: Clinical Immunology

ja: 臨床免疫


en: 接触性過敏症における樹状細胞の役割

ja: 接触性過敏症における樹状細胞の役割

en: アレルギー科

ja: アレルギー科


en: 自己免疫疾患における分子模倣仮説

ja: 自己免疫疾患における分子模倣仮説

en: Journal of Clinical and Experimental Medicine

ja: 医学のあゆみ


en: シェ-グレン症候群発症の分子機構

ja: シェ-グレン症候群発症の分子機構


en: 免疫異常からみたリウマチ性疾患の臓器病変:口腔内病変

ja: 免疫異常からみたリウマチ性疾患の臓器病変:口腔内病変

en: リウマチ科

ja: リウマチ科


en: 令和4年度 徳島大学高等教育研究センターアドミッション部門 報告書

ja: 令和4年度 徳島大学高等教育研究センターアドミッション部門 報告書

en: 令和4年度 徳島大学高等教育研究センターアドミッション部門 報告書

ja: 令和4年度 徳島大学高等教育研究センターアドミッション部門 報告書

misc_type: others


en: 令和3年度 徳島大学高等教育研究センターアドミッション部門 報告書

ja: 令和3年度 徳島大学高等教育研究センターアドミッション部門 報告書

en: 令和3年度 徳島大学高等教育研究センターアドミッション部門 報告書

ja: 令和3年度 徳島大学高等教育研究センターアドミッション部門 報告書


en: The Thymus and T-Cell Specificity

ja: The Thymus and T-Cell Specificity

en: The Scripps Research Institute Scientific Report