徳島大学 / 教育研究者総覧 --- 金丸芳

個人のホームページ

https://researchmap.jp/read0054357 (researchmap)

専門分野

○	食品加工保蔵学
○	食品機能学 (Functional Food Science)
○	調理科学

研究テーマ

○	食品成分による抗微生物作用と食品保蔵への応用 (食中毒菌, 腐敗菌, 抗菌活性, 抗酸化活性, 食品加工)
○	食品成分や環境物質による細胞への影響 (細胞保護作用, 細胞毒性, 抗ガン活性, 有用菌増殖活性, 免疫賦活活性, 食品資源の循環利用)
○	調理文化の地域性と郷土食の調査研究 (郷土食, 食文化, 調理)

著書・論文

著書:

1.	橋爪正樹, 右手浩一, 井﨑ゆみ子, 大野将樹, 中野晋, 溝渕啓, 玉谷純二, 下村直行, 上田隆雄, 上野勝利, 長尾文明, 橋本親典, 武藤裕則, 渡邉健, 木戸崇博, 片山哲郎, 山下陽子, 田端厚之, 佐々木由香, 島木美香, 音井威重, 金丸芳, 服部武文, 濵野龍夫, 宮脇克行, 安間了, 西山賢一, 青矢睦月 : 安全マニュアル, 2021年4月.

学術論文(審査論文):

1.	Chizuru Sasaki, Satoshi Tamura, Miyuki Suzuki, Kanako Etomi, Nobuya Nii, Junji Hayashi and Kaori Kanemaru : Continuous microwave-assisted step-by-step extraction of bioactive water-soluble materials and fucoidan from brown seaweed Undaria pinnatifida waste, Biomass Conversion and Biorefinery, Vol.14, 7673-7682, 2024. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s13399-022-03035-6 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1007/s13399-022-03035-6 (DOI: 10.1007/s13399-022-03035-6)
2.	Rumana Yesmin Hasi, Toshiki Ishikawa, Keigo Sunagawa, Yoshimichi Takai, Hanif Ali, Junji Hayashi, Ryushi Kawakami, Keizo Yuasa, Mutsumi Aihara, Kaori Kanemaru, Hiroyuki Imai and Tamotsu Tanaka : Nonspecific phospholipase C3 of radish has phospholipase D activity toward glycosylinositol phosphoceramide, FEBS Letters, Vol.596, No.23, 3024-3036, 2022. (要約) Glycosylinositol phosphoceramide (GIPC) is a major sphingolipid in the plasma membranes of plants. Previously, we found an enzyme activity that produces phytoceramide 1-phosphate (PC1P) by hydrolysis of the D position of GIPC in cabbage and named this activity as GIPC-phospholipase D (PLD). Here, we purified GIPC-PLD by sequential chromatography from radish roots. Peptide mass fingerprinting analysis revealed that the potential candidate for GIPC-PLD protein was nonspecific phospholipase C3 (NPC3), which has not been characterized as a PLD. The recombinant NPC3 protein obtained by heterologous expression system in Escherichia coli produced PC1P from GIPC and showed essentially the same enzymatic properties as those we characterized as GIPC-PLD in cabbage, radish and Arabidopsis thaliana. From these results, we conclude that NPC3 is one of the enzymes that degrade GIPC. (キーワード) Phospholipase D / Raphanus / Phospholipases / Sphingolipids / Brassica / Arabidopsis (徳島大学機関リポジトリ) ● Metadata: 117824 (出版サイトへのリンク) ● Publication site (DOI): 10.1002/1873-3468.14520 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36266963 ● Search Scopus @ Elsevier (PMID): 36266963 ● Search Scopus @ Elsevier (DOI): 10.1002/1873-3468.14520 (徳島大学機関リポジトリ: 117824, DOI: 10.1002/1873-3468.14520, PubMed: 36266963)
3.	Ali Hanif, Morito Katsuya, Rumana Hasi Yesmin, Mutsumi Aihara, Junji Hayashi, Ryushi Kawakami, Kaori Kanemaru, Koichiro Tsuchiya, Sango Kazunori and Tamotsu Tanaka : Characterization of uptake and metabolism of very long-chain fatty acids in peroxisome-deficient CHO cells, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Vol.1867, No.2, 159088, 2022. (要約) Fatty acids (FAs) longer than C20 are classified as very long-chain fatty acids (VLCFAs). Although biosynthesis and degradation of VLCFAs are important for the development and integrity of the myelin sheath, knowledge on the incorporation of extracellular VLCFAs into the cells is limited due to the experimental difficulty of solubilizing them. In this study, we found that a small amount of isopropanol solubilized VLCFAs in aqueous medium by facilitating the formation of the VLCFA/albumin complex. Using this solubilizing technique, we examined the role of the peroxisome in the uptake and metabolism of VLCFAs in Chinese hamster ovary (CHO) cells. When wild-type CHO cells were incubated with saturated VLCFAs (S-VLCFAs), such as C23:0 FA, C24:0 FA, and C26:0 FA, extensive uptake was observed. Most of the incorporated S-VLCFAs were oxidatively degraded without acylation into cellular lipids. In contrast, in peroxisome-deficient CHO cells uptake of S-VLCFAs was marginal and oxidative metabolism was not observed. Extensive uptake and acylation of monounsaturated (MU)-VLCFAs, such as C24:1 FA and C22:1 FA, were observed in both types of CHO cells. However, oxidative metabolism was evident only in wild-type cells. Similar manners of uptake and metabolism of S-VLCFAs and MU-VLCFAs were observed in IFRS1, a Schwan cell-derived cell line. These results indicate that peroxisome-deficient cells limit intracellular S-VLCFAs at a low level by halting uptake, and as a result, peroxisome-deficient cells almost completely lose the clearance ability of S-VLCFAs accumulated outside of the cells. (徳島大学機関リポジトリ) ● Metadata: 116579 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.bbalip.2021.159088 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34848380 ● Search Scopus @ Elsevier (PMID): 34848380 ● Search Scopus @ Elsevier (DOI): 10.1016/j.bbalip.2021.159088 (徳島大学機関リポジトリ: 116579, DOI: 10.1016/j.bbalip.2021.159088, PubMed: 34848380)
4.	Rumana Yesmin Hasi, Dai Majima, Katsuya Morito, Hanif Ali, Kentaro Kogure, Meera Nanjundan, Junji Hayashi, Ryushi Kawakami, Kaori Kanemaru and Tamotsu Tanaka : Isolation of glycosylinositol phosphoceramide and phytoceramide 1-phosphate in plants and their chemical stabilities., Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, Vol.1152, 122213, 2020. (要約) Glycosylinositol phosphoceramide (GIPC) is a sphingophospholipid in plants. Recently, we identified that GIPC is hydrolyzed to phytoceramide 1-phosphate (PC1P) by an uncharacterized phospholipase D activity following homogenization of certain plant tissues. We now developed methods for isolation of GIPC and PC1P from plant tissues and characterized their chemical stabilities. Hydrophilic solvents, namely a lower layer of a mixed solvent system consisting of isopropanol/hexane/water (55:20:25, v/v/v) was efficient solvent for extraction and eluent in column chromatography. GIPC was isolated by Sephadex column chromatography followed by TLC. A conventional method, such as the Bligh and Dyer method, was applicable for PC1P extraction. Specifically, PC1P was isolated by TLC following mild alkali treatment of lipid extracts of plants. The yields of GIPC and PC1P in our methods were both around 50-70%. We found that PC1P is tolerant against heat (up to 125 °C), strong acid (up to 10 M HCl), and mild alkali (0.1 M KOH). In contrast, significant degradation of GIPC occurred at 100 °C and 1.0 M HCl treatment, suggesting the instability of the inositol glycan moiety in these conditions. These data will be useful for further biochemical and nutritional studies on these sphingolipids. (徳島大学機関リポジトリ) ● Metadata: 115195 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jchromb.2020.122213 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32615533 ● Search Scopus @ Elsevier (PMID): 32615533 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jchromb.2020.122213 (徳島大学機関リポジトリ: 115195, DOI: 10.1016/j.jchromb.2020.122213, PubMed: 32615533)
5.	Hitomi Sakai, Tohru Sakai, Badr Ali Hoida, Kaori Kanemaru and Kumio Yokoigawa : Analysis of cereal extracts as conditioning solutes to suppress the initial attachment of Escherichia coli to abiotic surfaces, European Food Research and Technology, 2020. (キーワード) Cereals / Escherichia coli / Attachment / Abiotic materials (徳島大学機関リポジトリ) ● Metadata: 114680 (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00217-020-03444-9 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-85081030075 (徳島大学機関リポジトリ: 114680, DOI: 10.1007/s00217-020-03444-9, Elsevier: Scopus)
6.	Hoida Ali Badr, Kaori Kanemaru, Yasuo Oyama and Kumio Yokoigawa : Suppressive effect of edible seaweeds on SOS response of Salmonella typhimurium induced by chemical mutagens, Journal of Environmental Studies, Vol.23, 30-40, 2020. (出版サイトへのリンク) ● Publication site (DOI): 10.21608/JESJ.2020.205278 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.21608/JESJ.2020.205278 (DOI: 10.21608/JESJ.2020.205278)
7.	Rumana Yesmin Hasi, Makoto Miyagi, Takashi Kida, Tatsuya Fukuta, Kentaro Kogure, Junji Hayashi, Ryushi Kawakami, Kaori Kanemaru and Tamotsu Tanaka : Quantitative Analysis of Glycosylinositol Phosphoceramide and Phytoceramide 1-Phosphate in Vegetables, Journal of Nutritional Science and Vitaminology, Vol.65, No.Supplement, S175-S179, 2019. (要約) Previously, we found an unidentified sphingolipid in cabbage, and determined it as phytoceramide 1-phosphate (PC1P). PC1P is found to be produced from glycosylinositol phosphoceramide (GIPC) by the action of phospholipase D (PLD) activity. Although GIPC is abundant sphingolipid, especially in cruciferous vegetables, amount of daily intake, digestibility and nutritional activity of GIPC are not well understood. Here, we investigated amounts of GIPC and PC1P in vegetables. GIPC was found in all vegetables examined (13 kinds) at levels 3-20 mg/100 g (wet weight). On the other hand, PC1P was present in limited vegetables which show higher GIPC-PLD activity, such as inner cabbage leaves (5.2 mg/100 g). Because PC1P is formed during homogenization by activated GIPC-PLD, level of PC1P in boiled cabbage leaves was very low. Although digestibility of GIPC is unknown at present, a portion of dietary GIPC is considered to be converted to PC1P during mastication by plant-derived GIPC-PLD activity in some vegetables. (キーワード) Brassica / Ceramides / Glycosphingolipids / Inositol / Phosphates / Phospholipase D / Plant Leaves / Sphingolipids / Vegetables (徳島大学機関リポジトリ) ● Metadata: 115197 (出版サイトへのリンク) ● Publication site (DOI): 10.3177/jnsv.65.S175 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31619623 ● Summary page in Scopus @ Elsevier: 2-s2.0-85073476996 (徳島大学機関リポジトリ: 115197, DOI: 10.3177/jnsv.65.S175, PubMed: 31619623, Elsevier: Scopus)
8.	Hasi Yesmin Rumana, Makoto Miyagi, Katsuya Morito, Toshiki Ishikawa, Maki Kawai-Yamada, Hiroyuki Imai, Tatsuya Fukuta, Kentaro Kogure, Kaori Kanemaru, Junji Hayashi, Ryushi Kawakami and Tamotsu Tanaka : Glycosylinositol phosphoceramide-specific phospholipase D activity catalyzes transphosphatidylation, The Journal of Biochemistry, Vol.166, No.5, 441-448, 2019. (要約) Glycosylinositol phosphoceramide (GIPC) is the most abundant sphingolipid in plants and fungi. Recently, we detected GIPC-specific phospholipase D (GIPC-PLD) activity in plants. Here, we found that GIPC-PLD activity in young cabbage leaves catalyzes transphosphatidylation. The available alcohol for this reaction is a primary alcohol with a chain length below C4. Neither secondary alcohol, tertiary alcohol, choline, serine nor glycerol serves as an acceptor for transphosphatidylation of GIPC-PLD. We also found that cabbage GIPC-PLD prefers GIPC containing two sugars. Neither inositol phosphoceramide, mannosylinositol phosphoceramide nor GIPC with three sugar chains served as substrate. GIPC-PLD will become a useful catalyst for modification of polar head group of sphingophospholipid. (キーワード) Biocatalysis / Brassica / Ceramides / Inositol / Molecular Structure / Phosphatidylcholines / Phospholipase D / Plant Leaves (徳島大学機関リポジトリ) ● Metadata: 113685 (出版サイトへのリンク) ● Publication site (DOI): 10.1093/jb/mvz056 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31504617 ● Summary page in Scopus @ Elsevier: 2-s2.0-85073764089 (徳島大学機関リポジトリ: 113685, DOI: 10.1093/jb/mvz056, PubMed: 31504617, Elsevier: Scopus)
9.	Yurie Funakoshi, Ayako Azuma, Mizuki Ishikawa, Satoru Itsuki, Yasuaki Tamura, Kaori Kanemaru, Shogo Hirai and Yasuo Oyama : Cytometrical analysis of the adverse effects of indican, indoxyl, indigo, and indirubin on rat thymic lymphocytes, Toxicology Research, Vol.7, 513-520, 2018. (要約) Many businesses thrive by producing health supplements from agricultural products, as exemplified by the production of functional (or health) food using plants traditionally cultivated in the rural areas. Dyes, such as indican, indigo, indoxyl, and indirubin, present in dye plants, possess antibacterial, antifungal, and antiproliferative activities. However, these effects may also lead to cytotoxicity. Thus, studies in normal mammalian cells are necessary to identify cytotoxicity and prevent adverse effects of functional foods that contain these dyes. In this study, the effects of indican, indigo, indoxyl, and indirubin were evaluated by flow cytometry using appropriate fluorescent probes in rat thymic lymphocytes. Among the dyes analyzed, indirubin exerted distinct cellular activities. Treatment with indirubin (10 30 µM) increased the population of shrunken dead cells. The side scatter, but not forward scatter, increased in indirubin-treated living cells. It increased the population of annexin V-bound living and dead cells and that of dead cells without annexin V. Indirubin elevated intracellular Ca2+, but not Zn2+ levels. The cellular content of superoxide anions and increased glutathione decreased. Indirubin depolarized the cellular plasma and mitochondrial membranes. It did not potentiate or attenuate the cytotoxicity of A23187 (Ca2+ overload) and H2O2 (oxidative stress). The results suggested that indirubin induces both apoptotic and non-apoptotic cell death. It may be difficult to predict and prevent adverse effects of indirubin due to its diverse activities on normal mammalian cells. Therefore, indirubin should be removed from products that contain dye plant extracts. (キーワード) Indigo / Indirubin / Indoxyl / Indican (徳島大学機関リポジトリ) ● Metadata: 111988 (出版サイトへのリンク) ● Publication site (DOI): 10.1039/C7TX00244K (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-85046849441 (徳島大学機関リポジトリ: 111988, DOI: 10.1039/C7TX00244K, Elsevier: Scopus)
10.	Honoka Wada, Keisuke Oyama, Risa Kamae, Toshiya Masuda, Kaori Kanemaru, Kumio Yokoigawa and Yasuo Oyama : Zinc-dependent and independent actions of hydroxyhydroquinone on rat thymic lymphocytes, Drug and Chemical Toxicology, Vol.9, 1-6, 2018. (要約) Coffee contains hydroxyhydroquinone (HHQ). HHQ is one of by-products released during bean roasting. Therefore, it is important to elucidate the bioactivity of HHQ to predict its beneficial or adverse effects on humans. We studied zinc-dependent and independent actions of commercially-procured synthetic HHQ in rat thymocytes using flow cytometric techniques with propidium iodide, FluoZin-3-AM, 5-chloromethylfluorescein diacetate, and annexin V-FITC. HHQ at 10¬50 µM elevated intracellular Zn2+ levels by releasing intracellular Zn2+. HHQ at 10 µM increased cellular thiol content in a Zinc-dependent manner. However, HHQ at 30 50 µM reduced cellular thiol content. Although the latter actions of HHQ (30 50 µM) were suggested to increase cell vulnerability to oxidative stress, HHQ at 0.3 100 µM significantly protected cells against oxidative stress induced by H2O2. The process of cell death induced by H2O2 was delayed by HHQ, although both H2O2 and HHQ increased the population of annexin V-positive living cells. However, HHQ at 10 30 µM promoted cell death induced by A23187, a calcium ionophore. HHQ at 10 30 µM exerted contrasting effects on cell death caused by oxidative stress and Ca2+ overload. Because HHQ is considered to possess diverse cellular actions, coffee with reduced amount of HHQ may be preferable to avoid potential adverse effects. (キーワード) Zinc / Hydroyxhydroquinone (徳島大学機関リポジトリ) ● Metadata: 111979 (出版サイトへのリンク) ● Publication site (DOI): 10.1080/01480545.2018.1429462 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1080/01480545.2018.1429462 (徳島大学機関リポジトリ: 111979, DOI: 10.1080/01480545.2018.1429462)
11.	Kaori Kanemaru, Goto Tsukie, Badr Ali Hoida and Kumio Yokoigawa : Determination of binding affinity of poly-gamma-glutamate to Shiga toxin, Journal of Food Biochemistry, Vol.42, No.5, e12538, 2018. (キーワード) Escherichia coli O157:H7 / Poly-gamma-glutamate / Shiga toxin (徳島大学機関リポジトリ) ● Metadata: 113899 (出版サイトへのリンク) ● Publication site (DOI): 10.1111/jfbc.12538 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1111/jfbc.12538 (徳島大学機関リポジトリ: 113899, DOI: 10.1111/jfbc.12538)
12.	Yumiko Nishimura-Danjobara, Keisuke Oyama, Kaori Kanemaru, Keiko Takahashi, Kumio Yokoigawa and Yasuo Oyama : N-(3-oxododecanoyl)-L-homoserine-lactone, a quorum sensing molecule, affects cellular content of nonprotein thiol content in rat lymphocytes: Its relation with intracellular Zn2+, Chemico-Biological Interactions, Vol.280, 28-32, 2018. (要約) Cellular actions of N-(3-oxododecanoyl)-L-homoserine-lactone (ODHL), a quorum sensing molecule of bacteria, were studied on rat thymocytes using a flow cytometer with appropriate fluorescent dyes to elucidate the effects of ODHL on host cells. A bell-shaped concentration-response relation was observed in the ODHL-induced changes in cellular glutathione content ([GSH]i). ODHL concentration-dependently increased intracellular Zn2+ levels ([Zn2+]i) and cellular O2- content ([O2-]i). The bell-shaped relation induced by ODHL can be explained as follows: a low concentration of ODHL is expected to induce moderate oxidative stress that intracellularly releases Zn2+ by converting thiols to disulfides. A slight elevation of [Zn2+]i may increase the [GSH]i. On the other hand, it is likely that a high concentration of ODHL causes severe oxidative stress that further causes both the decrease in [GSH]i and the increase in [Zn2+]i. Excessive increase in [Zn2+]i may augment oxidative stress that further decreases the [GSH]i. Other notable actions induced by ODHL included the elevation of [Zn2+]i by Zn2+ influx and the increase in [GSH]i under Zn2+-free conditions. Therefore, it is suggested that ODHL elicits diverse actions on host cells. (キーワード) 4-Butyrolactone / Animals / Apoptosis / Cells, Cultured / Glutathione / Homoserine / Lymphocytes / Male / Oxidative Stress / Quorum Sensing / Rats / Rats, Wistar / Sulfhydryl Compounds / Thymus Gland / Zinc (徳島大学機関リポジトリ) ● Metadata: 111976 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.cbi.2017.12.013 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29223568 ● Search Scopus @ Elsevier (PMID): 29223568 ● Search Scopus @ Elsevier (DOI): 10.1016/j.cbi.2017.12.013 (徳島大学機関リポジトリ: 111976, DOI: 10.1016/j.cbi.2017.12.013, PubMed: 29223568)
13.	Norio Kamemura, Keisuke Oyama, Kaori Kanemaru, Kumio Yokoigawa and Yasuo Oyama : Diverse cellular actions of tert-butylhydroquinone, a food additive, on rat thymocytes, Toxicology Research, Vol.6, 922-929, 2017. (要約) Tertiary butylhydroquinone (TBHQ) is a food additive that possesses antioxidant activity. Its alternative applications have been explored in recent studies. However, there is controversy regarding safety. In this study using rat thymocytes, the cellular actions of TBHQ at sublethal concentrations were examined. TBHQ at concentrations of 3 µM or more elevated intracellular Zn2+ concentration ([Zn2+]i) in a dose-dependent manner, by increasing membrane Zn2+ permeability and releasing Zn2+ from cellular stores. TBHQ at 30 µM significantly increased side scatter (cell density) and the exposure of phosphatidylserine (PS) on cell membrane surfaces. It also decreased cellular glutathione (GSH) content without affecting cell lethality. Forward scatter was attenuated by 100 µM TBHQ. Thus, it is considered that TBHQ at sublethal concentrations (30 µM or less) exerts some adverse actions on cells. TBHQ at 10 30 µM attenuated the increase in cell lethality induced by hydrogen peroxide (H2O2), while potentiation of H2O2 cytotoxicity by 100 µM TBHQ was observed. The range of concentrations of TBHQ from benefit to toxicity under in vitro conditions may be 10 30 µM. Although TBHQ exhibits antioxidative actions at concentrations that are lower than those which elicit adverse cellular effects, sublethal levels of TBHQ cause some adverse actions that may be clinically concerned. (キーワード) food additive (徳島大学機関リポジトリ) ● Metadata: 111981 (出版サイトへのリンク) ● Publication site (DOI): 10.1039/C7TX00183E (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1039/C7TX00183E (徳島大学機関リポジトリ: 111981, DOI: 10.1039/C7TX00183E)
14.	Badr Ali Hoida, Takahashi Keiko, Ryushi Kawakami, Yasuo Oyama, Kumio Yokoigawa and Kaori Kanemaru : Screening and analysis of edible seaweeds in the ability to adsorb Shiga toxin., European Food Research and Technology, Vol.243, No.12, 2147-2153, 2017. (キーワード) Shiga toxin / Seaweed / Ulva linza Linnaeus / Rhamnan sulfate (徳島大学機関リポジトリ) ● Metadata: 111019 (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00217-017-2915-1 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1007/s00217-017-2915-1 (徳島大学機関リポジトリ: 111019, DOI: 10.1007/s00217-017-2915-1)
15.	Maki Takeda, Keisuke Oyama, Norio Kamemura, Kaori Kanemaru, Keizo Yuasa, Kumio Yokoigawa and Yasuo Oyama : Change in plasma membrane potential of rat thymocytes by tert-butylhydroquinone, a food additive: Possible risk on lymphocytes, Food and Chemical Toxicology, Vol.109, No.1, 296-301, 2017. (要約) Tertiary butylhydroquinone (TBHQ) is a food additive and has various beneficial actions under in vitro and in vivo experimental conditions. Therefore, it is necessary to collect additional data on the toxicity of TBHQ in order to avoid adverse effects during clinical applications. Changes in plasma membrane potential are associated with changes in physiological functions even in non-excitable cells such as lymphocytes. Thus, compounds that affect membrane potential may modify some lymphocytic functions. The effect of TBHQ on plasma membrane potential was examined in rat thymocytes using flow cytometric techniques. Treatment of rat thymocytes with TBHQ caused hyperpolarization and then depolarization. The TBHQ-induced hyperpolarization was due to the activation of Ca2+-dependent K+ channels. TBHQ elevated intracellular Ca2+ levels. The depolarization by TBHQ was caused by a nonspecific increase in membrane ionic permeability. Both the sustained depolarization and elevation of intracellular Ca2+ level by TBHQ are thought to be adverse for thymocytes because such changes disturb membrane and intracellular signaling. The thymus is most active during neonatal and pre-adolescent periods. If TBHQ exerts adverse actions on thymocytes, it may result in an immunotoxic effect in neonates and adolescents. (キーワード) tert-butylhydroquinone / food additive / membrane potential / lymphocytes / calcium (徳島大学機関リポジトリ) ● Metadata: 111984 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.fct.2017.09.017 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28899772 ● Summary page in Scopus @ Elsevier: 2-s2.0-85029351916 (徳島大学機関リポジトリ: 111984, DOI: 10.1016/j.fct.2017.09.017, PubMed: 28899772, Elsevier: Scopus)
16.	Goto Tsukie, Makiko Tsuji, Kaori Kanemaru and Kumio Yokoigawa : Adsorption of Shiga Toxin to Poly-γ Glutamate Precipitated., Journal of Food Science, Vol.81, No.12, 2977-2981, 2016. (徳島大学機関リポジトリ) ● Metadata: 111020 (出版サイトへのリンク) ● Publication site (DOI): 10.1111/1750-3841.13540 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1111/1750-3841.13540 (徳島大学機関リポジトリ: 111020, DOI: 10.1111/1750-3841.13540)
17.	Eiko Niwa, Tsuyoshi Mitani, Shohei Saitoh, Kaori Kanemaru, Shiro Ishida, Kumio Yokoigawa and Yasuo Oyama : Zinc increases vulnerability of rat thymic lymphocytes to arachidonic acid under in vitro conditions, Food and Chemical Toxicology, Vol.96, 177-182, 2016. (要約) Previous studies on the cytotoxicity of arachidonic acid (ARA) elucidated the involvement of oxidative stress and Ca2+. In the present study, the Zn2+-related cytotoxicity of ARA was studied by a flow cytometric technique with appropriate fluorescent probes in rat thymocytes. Addition of 10 µM ZnCl2 enhanced the increase in cell lethality induced by 10 µM ARA. The removal of Zn2+ by Zn2+ chelators attenuated the ARA-induced increase in cell lethality. Thus, Zn2+ is suggested to be involved in ARA cytotoxicity. ARA at 3 10 µM elevated intracellular Zn2+ level. The Zn2+ chelators attenuated the ARA-induced increase in intracellular Zn2+ level while ARA significantly increased intracellular Zn2+ level in the presence of 3 µM ZnCl2, suggesting the involvement of external Zn2+. Zn2+ reportedly exerts cytotoxic action under oxidative stress induced by hydrogen peroxide, via an excessive increase in intracellular Zn2+ levels. Since ARA induces oxidative stress, the simultaneous administration of zinc and ARA may be harmful. (キーワード) Polyunsaturated fatty acids (徳島大学機関リポジトリ) ● Metadata: 110419 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.fct.2016.08.008 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27515868 ● Search Scopus @ Elsevier (PMID): 27515868 ● Search Scopus @ Elsevier (DOI): 10.1016/j.fct.2016.08.008 (徳島大学機関リポジトリ: 110419, DOI: 10.1016/j.fct.2016.08.008, PubMed: 27515868)
18.	Hiromitsu Tsuzuki, Shota Inoue, Daiki Kobayashi, Gantulga Uuganbaatar, Kaori Kanemaru, Kumio Yokoigawa and Yasuo Oyama : Methyl cinnamate increases cell vulnerability to oxidative stress induced by hydrogen peroxide in rat thymocytes, Fundamental Toxicological Sciences, Vol.3, No.3, 121-125, 2016. (要約) Methyl cinnamate (MC) and essential oils containing MC possess beneficial antimicrobial, antifungal, and insecticidal effects, among others. Such effects are related to the biocidal action of MC. The antioxidant activity of MC has also been reported elsewhere. It has been suggested that MC may be cytotoxic to cells exposed to oxidative stress. To test this possibility, the effect of MC on rat thymocytes was examined while the cells were subjected to oxidative stress induced by hydrogen peroxide (H2O2). Flow cytometric techniques with appropriate fluorescent probes were used for quantification. MC increased cell vulnerability to oxidative stress via acceleration of the cell death process and/or potentiation of oxidative stress. The use of MC is widespread because of its beneficial actions, and thus further attention should be paid to whether MC is effective under oxidative stress. (徳島大学機関リポジトリ) ● Metadata: 110051 (出版サイトへのリンク) ● Publication site (DOI): 10.2131/fts.3.121 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.2131/fts.3.121 (徳島大学機関リポジトリ: 110051, DOI: 10.2131/fts.3.121)
19.	松下純子, 後藤月江, 金丸芳, 遠藤千鶴, 長尾久美子, 有内尚子, 高橋啓子 : 徳島県における行事食の現状, 日本調理科学会誌, Vol.47, No.1, 42-48, 2014年. (要約) 日本の調理文化の地域性の特別研究のうち，平成21年から平成22年に「行事食・儀礼食」についてアンケート調査を行った．徳島県に10年以上在住する人を対象に，正月を除く年中行事について30歳未満，30歳以上50歳未満，50歳以上の年代区分に分類し検討した．人日，端午の節句，七夕，土用の丑，盂蘭盆，重陽の節句，春分の日，秋分の日，冬至，秋祭りでは，認知率および経験率の双方に年代区分で有意差がみられた．節分「巻き寿司・のり巻き」，土用の丑「うなぎの蒲焼き」は行事食としての喫食率が高かった．春分の日，秋分の日の「ご飯・だんご」，春祭り，秋祭りの「ご飯・すし」は，若い世代への伝承が薄れていることが推察された．全ての年代区分で年末のクリスマス，大みそかは行事として定着しており，「ケーキ」や「年越しそば」を多く食べていた．多くの行事食は以前には家庭で作ったが，現在は買う入手方法へ変化しており，特に50歳以上で顕著であった． (キーワード) 行事 / 行事食 / 徳島 (出版サイトへのリンク) ● Publication site (DOI): 10.11402/cookeryscience.47.42 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390282680481393536 ● Search Scopus @ Elsevier (DOI): 10.11402/cookeryscience.47.42 (DOI: 10.11402/cookeryscience.47.42, CiNii: 1390282680481393536)
20.	後藤月江, 松下純子, 金丸芳, 遠藤千鶴, 長尾久美子, 有内尚子, 高橋啓子 : 徳島県における通過儀礼食の現状, 日本調理科学会誌, Vol.46, No.6, 389-394, 2013年. (キーワード) 徳島 / 通過儀礼 / 通過儀礼食 (出版サイトへのリンク) ● Publication site (DOI): 10.11402/cookeryscience.46.389 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390282680482791936 ● Search Scopus @ Elsevier (DOI): 10.11402/cookeryscience.46.389 (DOI: 10.11402/cookeryscience.46.389, CiNii: 1390282680482791936)
21.	Yusuke Takahashi, Kaori Kanemaru, Shoji Imai, Norikazu Miyoshi, Takuya Kawanai and Yasuo Oyama : Yttrium decreases the intracellular Zn²⁺ concentration in rat thymocytes by attenuating a temperature-sensitive Zn²⁺ influx, Environmental Toxicology and Pharmacology, Vol.34, No.2, 574-578, 2012. (要約) Yttrium is used in the production of various electronic devices because the alloy it contains enhances or modifies the properties of other elements. In order to study the cytotoxic action of yttrium, the effect of yttrium chloride (YCl3) on the intracellular Zn2+ level was examined in rat thymocytes using a flow cytometer with FluoZin-3-AM and propidium iodide. The application of YCl3 significantly decreased the intensity of the FluoZin-3 fluorescence, suggesting a decrease in the intracellular Zn2+ level or quenching of the FluoZin-3 fluorescence by Y3+. However, since Y3+ did not attenuate the FluoZin-3 fluorescence under cell-free conditions, the latter suggestion was ruled out. Rat thymocytes possess a temperature-sensitive membrane pathway that carries Zn2+ into the cells. The application of YCl3 attenuated the FluoZin-3 fluorescence augmented by externally applied ZnCl2 in a concentration-dependent manner. This suggested that Y3+ inhibited the Zn2+ influx, resulting in the decrease in the intracellular Zn2+ level. Yttrium may induce dyshomeostasis of intracellular Zn2+, leading to some cytotoxic actions. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.etap.2012.07.002 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22854244 ● Summary page in Scopus @ Elsevier: 2-s2.0-84864332430 (DOI: 10.1016/j.etap.2012.07.002, PubMed: 22854244, Elsevier: Scopus)
22.	Kazuki Koizumi, Kawanai Takuya, Erika Hashimoto, Yasuhiro Kanbara, Toshiya Masuda, Kaori Kanemaru, Yoshiro Okano and Yasuo Oyama : Cytometric analysis on cytotoxicity of curcumin on rat thymocytes: Proapoptotic and antiapoptotic actions of curcumin, Toxicology In Vitro, Vol.25, No.4, 985-990, 2011. (要約) Curcumin exhibits various pharmacological actions including anti-inflammatory, anti-infectious, and anticancer actions. Furthermore, the supplements containing curcumin are supplied for persons consuming alcoholic beverage. A primary criterion for an ingredient ingested by general population is that it exerts no harmful effect. In this study, we examined the effect of curcumin on rat thymocytes to see if curcumin exerts cytotoxicity on normal cells. The incubation with 10 µM curcumin for 24 h increased the population of dead cells while it was not the case for 5 µM or less. Curcumin at 5-10 µM increased the populations of shrunken cells and the cells positive to annexin V, phenomena for early stage of apoptosis. However, the incubation with 10 µM curcumin suppressed the increase in population of cells with hypodiploid DNA, a phenomenon for late stage of apoptosis. Thus, curcumin at 10 µM may show both proapoptotic and antiapoptotic actions. The simultaneous incubation with 5 µM, but not 3 µM, curcumin and 0.5 % ethanol increased the population of shrunken cells. It is likely that curcumin at 5 µM or more exerts cytotoxic action on normal cells although many studies show some anticancer actions of curcumin at 10 µM or more on cancer cells. (キーワード) Animals / Annexin A5 / Antineoplastic Agents / Apoptosis / Curcumin / Dose-Response Relationship, Drug / Flow Cytometry / Rats / Rats, Wistar / Thymus Gland (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.tiv.2011.03.010 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21419841 ● Search Scopus @ Elsevier (PMID): 21419841 ● Search Scopus @ Elsevier (DOI): 10.1016/j.tiv.2011.03.010 (DOI: 10.1016/j.tiv.2011.03.010, PubMed: 21419841)
23.	Yoshimi Shingai, Aya Fujimoto, Asuka Nakajima, Minoru Saito, Kaori Kanemaru, Toshiya Masuda and Yasuo Oyama : Cytotoxic characteristics of two isomeric dimers produced by oxidation of sesamol, an antioxidant in sesame oil, Journal of Health Science, Vol.57, No.5, 425-431, 2011. (要約) Antioxidants themselves are oxidized to prevent oxidation of other molecules. One may ask if the oxidized antioxidants are safe for humans. However, there is very little information on the toxicity of oxidized antioxidants. We previously identified cytotoxic compounds in the products from oxidation of sesamol, a potent antioxidant in sesame oil. In this study using a flow cytometer with fluorescent probes, we revealed cytotoxic characteristics of two isomeric dimers (dimer A and B) in rat thymocytes. Increase in cell lethality by dimer A was more profound than those by sesamol and dimer B. The incubation of cells with dimer A increased the populations of shrunken cells and the cells with phosphatidylserine exposed on outer surface of cell membranes. Since these phenomena are parameters for early stage of apoptosis, the results indicate that dimer A may promote the process of apoptosis. However, the population of the cells containing hypodiploid DNA, a parameter for late stage of apoptosis, was decreased by the incubation with dimer A. It was not the case for dimer B. Results indicate that dimer A may inhibit the degradation of DNA during apoptosis. Taken together, it is likely that dimer A exerts both proapoptotic action and inhibitory action on late stage of apoptosis in rat thymocytes. (キーワード) antioxidant / apoptosis / cytotoxicity / oxidation / sesamol (出版サイトへのリンク) ● Publication site (DOI): 10.1248/jhs.57.425 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001204498372864 ● Search Scopus @ Elsevier (DOI): 10.1248/jhs.57.425 (DOI: 10.1248/jhs.57.425, CiNii: 1390001204498372864)
24.	山本真由美, 長積仁, 大橋眞, 金丸芳, 寺嶋吉保, 長宗雅美 : 特別支援教育における学生ボランティアの活用の試み, 大学教育研究ジャーナル, Vol.0, No.6, 102-107, 2010年. (要約) 障害を持つ児童生徒への教育は特別支援教育に移行し，学習障害， ADHD，高機能自閉症(広汎性発達障害)などの新しい障害領域が加えられた．制度的にはこのような変化があるが，学校現場の支援体制は物的環境，人的環境において整っていない．大学が県・市の教育委員会と連携し，大学生を学習支援ボランティアとして小中学校に派遣し，教員の補助的役割を担うことは，特別支援教育にとってどのような影響があるかを報告することを目的とした．県・市の教育委員会から各10名程度の大学生の募集があったので， 3・4年生を対象として募集した．募集に応じた学生は事前オリエンテーションを各教育委員会から受け，小中学校に4時間/1日，派遣された．派遣校教員と学生ボランティアへの面接，質問紙調査から「教室に支援の手と目が増えた(学習支援ボランティアがいることで子どもをみてくれる人が増え，支援してくれる人が増えた)」，「子どもの反応から対応を考えるカがついた」などの評価が得られた． (キーワード) 特別支援教育 / 大学生 / ボランティア (volunteer) / 教育委員会 (徳島大学機関リポジトリ) ● Metadata: 82695 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050564287417205632 (徳島大学機関リポジトリ: 82695, CiNii: 1050564287417205632)
25.	Yoko Sakanashi, Midori Morimoto, Yumiko Nishimura, Hiroko Matsui, Kaori Kanemaru, Toshiya Masuda and Yasuo Oyama : Cytometric analysis of the cytotoxic action of adenosine 5'-monophosphate on rat thymocytes, Journal of Health Science, Vol.54, No.6, 692-696, 2008. (要約) The cascade of adenosine 5'-monophosphate -activated protein kinase (AMPK) is known to be a sensor of cellular energy charge. In this context, a paradigm for obesity treatment via the activation of AMPK has attracted the suppliers of complementary medicines and supplements. It is possible that products that increase the concentration of adenosine 5'-monophosphate (AMP) in the body would be efficacious in reducing body weight. However, since there is currently little information concerning the toxicity of AMP, the cytotoxic action of AMP on rat thymocytes was examined by flow cytometry. Incubation of cells with AMP at a concentration of 30 µM or more for 24 h significantly increased the populations of dead cells, shrunken cells, and cells containing hypodiploidal DNA in a concentration-dependent manner. Z-VAD-FMK, a pan-inhibitor of caspases, attenuated the AMP-induced changes in cell populations. It is concluded that AMP at a concentration of 30 µM or more exerts a cytotoxic action, which is dependent on the activation of caspases. (キーワード) cytotoxicity / adenosine 5'-monophosphate / flow cytometry / thymocyte (出版サイトへのリンク) ● Publication site (DOI): 10.1248/jhs.54.692 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001204497739648 ● Search Scopus @ Elsevier (DOI): 10.1248/jhs.54.692 (DOI: 10.1248/jhs.54.692, CiNii: 1390001204497739648)
26.	川染節江, 板倉一枝, 松島文子, 横山弥枝, 奥野元子, 安藤真美, 神田知子, 五島淑子, 櫻井菜穂子, 花井玲子, 井川佳子, 奥田弘枝, 岡本洋子, 小園佳美, 人見哲子, 和田治子, 藤井わか子, 宇高順子, 亀岡恵子, 峰弘子, 川端和子, 武田珠美, 小西文子, 金丸芳 : 災害時のメニュー開発 -中国・四国支部報告-, 日本調理科学会誌, Vol.41, No.1, 64-68, 2008年.
27.	Kanna Horimoto, Yumiko Nishimura, Tomohiro Oyama, Kyoko Onoda, Hiroko Matsui, Toshihisa Oyama, Kaori Kanemaru, Toshiya Masuda and Yasuo Oyama : Reciprocal effects of glucose on the process of cell death induced by calcium ionophore or H2O2 in rat lymphocytes, Toxicology, Vol.225, No.2-3, 97-108, 2006. (要約) We have examined the effects of glucose at high concentrations on the process of cell death induced by excessive increase in intracellular Ca2+ concentration ([Ca2+]i) or oxidative stress in rat lymphocytes. The cell death elicited by the excessive increase in [Ca2+]i seemed to be induced by an activation of Ca2+-dependent K+ channels because the inhibitors for Ca2+-dependent K+ channels attenuated the decrease in cell viability. Glucose at 30-50 mM augmented the decrease in cell viability by the excessive increase in [Ca2+]i. It was not specific for glucose because it was the case for sucrose or NaCl, suggesting an involvement of increased osmolarity in adverse action of glucose. On the contrary, glucose protected the cells suffering from oxidative stress induced by H2O2, one of reactive oxygen species. It was also the case for fructose or sucrose, but not for NaCl. The process of cell death induced by H2O2 started, being independent from the presence of glucose. Glucose delayed the process of cell death induced by H2O2. Sucrose and fructose also protected the cells against oxidative stress. The reactivity of sucrose to reactive oxygen species is lower than those of glucose and fructose. The order in the reactivity cannot explain the protective action of glucose. Glucose at high concentrations exerts reciprocal actions on the process of cell death induced by the oxidative stress and excessive increase in [Ca2+]i. (キーワード) Animals / Calcimycin / Calcium / Cell Death / Cell Survival / Charybdotoxin / Clotrimazole / Dose-Response Relationship, Drug / Flow Cytometry / Glucose / Hydrogen Peroxide / Ionophores / Male / Osmolar Concentration / Oxidative Stress / Rats / Rats, Wistar / T-Lymphocytes (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.tox.2006.05.004 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16784802 ● Search Scopus @ Elsevier (PMID): 16784802 ● Search Scopus @ Elsevier (DOI): 10.1016/j.tox.2006.05.004 (DOI: 10.1016/j.tox.2006.05.004, PubMed: 16784802)
28.	Yumiko Nishimura, Jun-ya Yamaguchi, Aimi Kanada, Kanna Horimoto, Kaori Kanemaru, Masaya Satoh and Yasuo Oyama : Increase in intracellular Cd²⁺ concentration of rat cerebellar granule neurons incubated with cadmium chloride: Cadmium cytotoxicity under external Ca²⁺-free condition, Toxicology In Vitro, Vol.20, No.2, 211-216, 2006. (要約) カドミウム毒性はカルシウムイオンの細胞機能の阻害との関連で示唆されることが多い．そこでカルシウムイオン除去条件下で，カドミウムイオンそれ自体が細胞レベルで同様な細胞毒性を示すことを明らかにした．細胞内でカドミウムイオン濃度の上昇を画像化して，カルシウムイオンの有無に関わらず，カドミウムイオンは同程度の細胞毒性を示した． (キーワード) カドミウム (cadmium) / 細胞毒性 (cytotoxicity) (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.tiv.2005.06.006 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16061347 ● Summary page in Scopus @ Elsevier: 2-s2.0-30644476948 (DOI: 10.1016/j.tiv.2005.06.006, PubMed: 16061347, Elsevier: Scopus)
29.	Yumiko Nishimura, Aimi Kanada, Jun-ya Yamaguchi, Kanna Horimoto, Masako Kobayashi, Tomoko Tatsuishi, Kaori Kanemaru, Shin-ya Ueno and Yasuo Oyama : Cytometric analysis of lidocaine-induced cytotoxicity: a model experiment using rat thymocytes, Toxicology, Vol.218, No.1, 48-57, 2006. (要約) 局所麻酔薬リドカインはアポトーシスあるいはネクローシスを起こすという報告がある．我々はリドカインがアポトーシス様細胞膜変化を起こした細胞に作用して，ネクローシスを起こさせることを明らかにした．よって，リドカインがアポトーシスを初期的に起こしても，最終的にはネクローシスという結果になる． (キーワード) リドカイン (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.tox.2005.09.016 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16263203 ● Summary page in Scopus @ Elsevier: 2-s2.0-28744459542 (DOI: 10.1016/j.tox.2005.09.016, PubMed: 16263203, Elsevier: Scopus)
30.	Aimi Kanada, Yumiko Nishimura, Jun-ya Yamaguchi, Masako Kobayashi, Kyoko Mishima, Kanna Horimoto, Kaori Kanemaru and Yasuo Oyama : Extract of Ginkgo biloba leaves attenuates kainate-induced increase in intracellular Ca²⁺ concentration of rat cerebellar granule neurons, Biological & Pharmaceutical Bulletin, Vol.28, No.5, 934-936, 2005. (要約) イチョウ葉エキスがグルタミン酸興奮毒性を抑制する可能性をラット脳神経細胞にて証明した．これにより，イチョウ葉エキスは認知症(痴呆症)の予防には有効である可能性が示唆された． (キーワード) Animals / Calcium / Cells, Cultured / Cerebellum / Dose-Response Relationship, Drug / Ginkgo biloba / Intracellular Fluid / Kainic Acid / Neurons / Plant Extracts / Plant Leaves / Rats / Rats, Wistar (出版サイトへのリンク) ● Publication site (DOI): 10.1248/bpb.28.934 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15863911 ● Search Scopus @ Elsevier (PMID): 15863911 ● Search Scopus @ Elsevier (DOI): 10.1248/bpb.28.934 (DOI: 10.1248/bpb.28.934, PubMed: 15863911)
31.	Hiromi Nakao, Kaori Senokuchi, Chisato Umebayashi, Kaori Kanemaru, Toshiya Masuda, Yasuo Oyama and Shigetomo Yonemori : Cytotoxic activity of maytanprine isolated from Maytenus diversifolia in human leukemia K562 cells, Biological & Pharmaceutical Bulletin, Vol.27, No.8, 1236-1240, 2004. (要約) We examined the cytotoxic effect of maytanprine isolated from the methanol extract of Maytenus diversifolia on human leukemia K562 cells using a flow cytometer and compared its cytotoxicity with that of maytansine, a potent cytotoxic maytansinoid. Maytanprine at concentrations of 0.03 nM or more (up to 1 nM) attenuated cell growth with decreasing cell viability and increased the population of shrunken cells in a concentration-dependent manner. Complete inhibition of growth by maytanprine was observed at concentrations of 0.3 nM or more. The compound at 0.03 nM markedly decreased the population at G0G1 phase in the cell cycle, but only slightly decreased that in the G2M phase, suggesting the possibility that it inhibits or delays cell division, and increased the population of cells with hypodiploidal DNA (apoptotic cells). The potency of maytanprine in inhibiting cell growth was greater than that of maytansine, although the inhibitory action of maytanprine was similar to that of maytansine. The results suggest that maytanprine exerts a potent inhibitory action on the growth of human leukemia K562 cells. M. diversifolia is one natural source of maytanprine, which is more cytotoxic than maytansine. (キーワード) Antineoplastic Agents / Cell Division / Flow Cytometry / Humans / K562 Cells / Maytansine (出版サイトへのリンク) ● Publication site (DOI): 10.1248/bpb.27.1236 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15305028 ● Search Scopus @ Elsevier (PMID): 15305028 ● Search Scopus @ Elsevier (DOI): 10.1248/bpb.27.1236 (DOI: 10.1248/bpb.27.1236, PubMed: 15305028)
32.	Chisato Umebayashi, Natsuko Yamamoto, Hiromi Nakao, Yukiko Toi, Lumi Chikahisa-Muramatsu, Kaori Kanemaru, Toshiya Masuda and Yasuo Oyama : Flow cytometric estimation of cytotoxic activity of rhodexin A isolated from Rhodea japonica in human leukemia K562 cells, Biological & Pharmaceutical Bulletin, Vol.26, No.5, 627-630, 2003. (キーワード) rhodexin (出版サイトへのリンク) ● Publication site (DOI): 10.1248/bpb.26.627 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12736502 ● Search Scopus @ Elsevier (PMID): 12736502 ● Search Scopus @ Elsevier (DOI): 10.1248/bpb.26.627 (DOI: 10.1248/bpb.26.627, PubMed: 12736502)
33.	Hiromi Hayashi, Hitomi Sakai, Wakako Minakuchi-Fijiwara, Miki Takayama, Michiko Nakamura-Murata, Yoshiko Kamo, Kanako Funakoshi, Keisuke Fukumoto, Kaori Kanemaru, Hideyuki Nakagawa, Yasuo Oyama, Nobuyuki Shinohara and Yoshihiro Ito : Cytokinesis arrest and nuclear fission in low density populations of Trichomonad Protozoan, Zoological Science, Vol.19, No.10, 1089-1094, 2002. (要約) Cell growth of anaerobic protozoan Tritrichomonas foetus was analyzed. This protozoan usually proliferates in extremely high density, but protozoan parasites were dispersed uniformly in F-bouillon medium and cell division stopped temporarily. However, nuclear fission continued and giant polynucleated cells formed. Later, cell division resumed and cells returned to normal form. In conditioned medium, cytokinesis of the dispersed parasites did not stop. Results indicated that T. foetus cells secreted an extracellular factor that influenced cytokinesis. (キーワード) Animals / Cell Division / Cell Nucleus / Culture Media / Oxygen / Population Density / Time Factors / Trichomonas (出版サイトへのリンク) ● Publication site (DOI): 10.2108/zsj.19.1089 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12426470 ● CiNii @ 国立情報学研究所 (CRID): 1522825128326665984 ● Search Scopus @ Elsevier (PMID): 12426470 ● Search Scopus @ Elsevier (DOI): 10.2108/zsj.19.1089 (DOI: 10.2108/zsj.19.1089, PubMed: 12426470, CiNii: 1522825128326665984)
34.	Yoshihiko Okada, Yasuo Oyama, Lumi Chikahisa, Kaori Kanemaru, Hitomi Sakai, Katuhiko Noda and Masaya Satoh : Tri-n-butyltin-induced decrease in cellular level of glutathione in rat thymocytes: a flow cytometric study using 5-chloromethylfluorescein diacetate, Toxicology Letters, Vol.117, 123-128, 2000. (キーワード) tri-n-butyltin
35.	Yasuo Oyama, Sachi Noguchi, Mami Nakata, Yoshihiko Okada, Yuko Yamazaki, Megumi Funai, Lumi Chikahisa and Kaori Kanemaru : Exposure of rat thymocytes to hydrogen peroxide increases annexin-V binding to membranes: inhibitory action of deferoxamine and quercetin, European Journal of Pharmacology, Vol.384, 47-52, 1999. (要約) 過酸化水素による酸化ストレスがカルシウムイオン依存性に細胞膜にアポトーシス様変化を起こさせることを明らかにした．実験にはラット胸腺細胞を用い，フローサイトメーターによりアネキシン結合，細胞膜透過性，細胞内カルシウムイオン濃度などの測定を行った．細胞内カルシウムイオン濃度の上昇に伴い，アネキシン結合(フォスファチジルセリン露出)が認められた．これらの実験から上記の結論を得た． (キーワード) oxidative stress
36.	Hideyuki Nakagawa, Chieko Yamaguchi, Hitomi Sakai, Kaori Kanemaru, Hiromi Hayashi, Yasutetsu Araki, Yasuhiro Tomihara, Mitsuko Shinohara, Kiyoshi Ohura and Hisato Kitagawa : Biochemical and physiological properties of pedicellarial lectins from the toxopneustid sea urchins, Journal of Natural Toxins, Vol.8, No.3, 297-308, 1999. (要約) ラッパウニの大型叉棘からゲル濾過，アフィニティークロマトグラフィー及びHPLCを用いて，D-ガラクトース特異的レクチン (SUL-I とSUL-II)ならびにシラヒゲウニの叉棘からヘパリン結合性レクチン(TGL-I)をそれぞれ単離した．SUL-I は強いマイトジェン活性を示し，ラットの血管内皮細胞に対してプロスタノイドの遊離を示唆した．TGL-I はマイトジェン活性を示さなかった． (キーワード) ラッパウニ / シラヒゲウニ / D-ガラクトース特異的レクチン / ヘパリン特異的レクチン / コントラクション (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10591033 ● Search Scopus @ Elsevier (PMID): 10591033 (PubMed: 10591033)
37.	Yasuo Oyama, Lumi Chikahisa, Kaori Kanemaru, Mami Nakata, Sachi Noguchi, Takayuki Nagano, Eisuke Okazaki and Akira Hirata : Cytotoxic actions of FTY720, a novel immunosuppressant, on thymocytes and brain neurons dissociated from the rat, The Japanese Journal of Pharmacology, Vol.76, 377-385, 1998. (キーワード) FTY720
38.	Yasuo Oyama, Lumi Chikahisa, Toshiko Ueha, Kaori Kanemaru and Katuhiko Noda : Ginkgo biloba extract protects brain neurons aganist oxidative stress induced by hydrogen peroxide, Brain Research, Vol.712, No.2, 349-352, 1996. (キーワード) Ginkgo biloba
39.	Eisuke Okazaki, Lumi Chikahisa, Kaori Kanemaru and Yasuo Oyama : Flow cytometric analysis on the H₂O₂-induced increase in intracellular Ca²⁺ concentration of rat thymocytes, The Japanese Journal of Pharmacology, Vol.71, No.4, 273-280, 1996. (キーワード) hydrogen peroxide
40.	金丸芳, 宮本悌次郎 : イソチオシアン酸アリルとその誘導体による細菌増殖阻害, 日本食品工業学会誌, Vol.38, No.10, 926-929, 1991年.
41.	Kaori Kanemaru and Teijiro Miyamoto : Inhibitory effects on the growth of several bacteria by brown mustard and allyl isothiocyanate, Nippon Shokuhin Kogyo Gakkaishi, Vol.37, No.10, 823-829, 1990.
42.	Kaori Kanemaru, Tomohisa Takaya and Teijiro Miyamoto : Separation and quantitation of allyl isothiocyanate in brown mustard and cinnamaldehyde in cinnamon by reverse-phase high performance liquid chromatography, Nippon Shokuhin Kogyo Gakkaishi, Vol.37, No.7, 565-568, 1990.

学術論文(紀要・その他):

1.	山口智美, 松家憲子, 先川正志, 金丸芳, 新居雅宏 : 乳酸菌発酵米飼料を活用した「阿波ポーク」生産技術の開発, 徳島県立農林水産総合技術支援センター畜産研究所研究報告, Vol.13, 27-30, 2014年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050282813732027520 (CiNii: 1050282813732027520)
2.	Hiroko Matsui, Yoko Sakanashi, Yumiko Nishimura, Kanna Horimoto, Kaori Kanemaru, Shiro Ishida, Yoshiro Okano and Yasuo Oyama : Cremophor EL modifies adriamycin-induced action on human leukemia K562 cells, Natural Science Research, Vol.21, 9-17, 2007. (要約) Adriamycin and paclitaxel are simultaneously used for cancer treatment in some cases. The formula of paclitaxel contains cremophor EL as a solvent. Since this solvent exerts diverse biological actions, the modification of adriamycin action by cremophor EL has been studied on human leukemia K562 cells. Cremophor EL did not significantly affect the concentration-response relation for antiproliferative action of adriamycin and the cell cycle changed by adriamycin. However, the induction of morphological change induced by adriamycin was significantly augmented by cremophor EL. The simultaneous application of cremophor EL increased the intensity of fluorescence from adriamycin trapped inside the cells in a concentration-dependent manner, suggesting an increase in intracellular concentration of adriamycin by cremophor EL. Adriamycin alone at concentrations higher than those to completely inhibit the growth induced morphological change in K562 cells. Therefore, cremophor EL may potentiate some of actions induced by adriamycin when adriamycin and paclitaxel are simultaneously applied. (キーワード) adriamycin / adriamycin / cremophor EL / cremophor el / cytotoxicity / cytotoxicity / human leukemia K562 cells / human leukemia k562 cells (徳島大学機関リポジトリ) ● Metadata: 117529 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050293633442989056 (徳島大学機関リポジトリ: 117529, CiNii: 1050293633442989056)
3.	Masako Kobayashi, Yoko Sakanashi, Hiroko Matsui, Yumiko Nishimura, Kaori Kanemaru, Yoshiro Okano and Yasuo Oyama : Micromolar zinc modifies the cell death induced by clotrimazole in human leukemia K562 cells, Natural Science Research, Vol.21, 1-8, 2007. (要約) Our recent study showed that the simultaneous application of clotrimazole with CdCl2 or PbCl2 exerted potent cytotoxic action in rat thymocytes although respective agents were ineffective. It was also the case of ZnCl2 and clotrimazole in preliminary study using rat thymocytes. Since clotrimazole is supposed to be a candidate for anticancer drug, we examined the effects of clotrimazole, ZnCl2, and their combination on human leukemia K562 cells. The combination of clotrimazole and ZnCl2 exerted potent cytotoxic effects on the growth and lethality of K562 cells by presumably modifying the process of cell death. The result suggests the possibility that endogenous Zn2+ may modify the action of clotrimazole. (キーワード) clotrimazole / clotrimazole / zinc / zinc / cytotoxicity / cytotoxicity / human leukemia K562 cells / human leukemia k562 cells (徳島大学機関リポジトリ) ● Metadata: 117528 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050856583396476800 (徳島大学機関リポジトリ: 117528, CiNii: 1050856583396476800)
4.	野田克彦, 金丸芳, 小山保夫 : レタス種子の生育に及ぼすナトリウムの影響, 徳島大学総合科学部自然科学研究, Vol.17, 63-67, 2003年.
5.	Hiromi Nakao, Yoshimi Narita, Lumi Chikahisa-Muramatu, Chisato Umebayashi, Kaori Kanemaru, Yasuo Oyama, Shiro Ishida and Okano Yoshiro : Further characterization of buthionine sulfoximine-induced potentiation of As2O3 cytotoxicity in human leukemia K562 cells: a flow cytometric study, Natural Science Research, Vol.17, 27-41, 2003.
6.	Yoshimi Narita, Yasuo Oyama, Tomohiro Arata, Kaori Kanemaru and Yoshiro Okano : Potentiation of As2O3-induced cytotoxicity by buthionine sulfoximine in human leukemia K562 cells, Natural Science Research, Vol.15, 21-34, 2002. (キーワード) arsenic trioxide
7.	Noriko Kajita, Lumi Chikahisa, Yuko Yamazaki, Norihiko Akaike, Kaori Kanemaru, Hitomi Sakai, Katuhiko Noda and Yasuo Oyama : Effects of the agents affecting membrane potassium permeability on growth and viability in human leukemia K562 cells, Natural Science Research, Vol.14, 35-46, 2001. (キーワード) potassium permeability
8.	Yoshihiko Okada, Yasuo Oyama, Toshiko Ueha-Ishibashi, Kaori Kanemaru, Norihiko Akaike, Norikazu Miyoshi and Masaya Satoh : Cytotoxic action of tri-n-butyltin hydride, a nucleaphilic triorganotin, on rat thymocytes: a flow cytometric study, Natural Science Research, Vol.14, 21-34, 2001. (キーワード) tri-n-butyltin
9.	Yasuo Oyama, Yoshihiko Okada, Norihiko Akaike, Kaori Kanemaru, Yumiko Kanemoto, Lumi Chikahisa, Masaya Satoh and Hiromi Hayashi : Protective action of tri-n-butyltin on the cells suffering from oxidative strss: Its implication in bioaccumulation, Natural Science Research, Vol.14, 9-20, 2001. (キーワード) tri-n-butyltin
10.	野田克彦, 金丸芳 : 心拍数を目安とした心肺機能の測定, 徳島大学総合科学部自然科学研究, Vol.13, 15-18, 2000年.
11.	野田克彦, 金丸芳, 小宮山朋子 : 簡易な方法で得られる体脂肪率と骨振動数の関連について, 徳島大学総合科学部自然科学研究, Vol.12, 9-14, 1999年.
12.	Kaori Kanemaru, Yasuo Oyama, Lumi Chikahisa, Mami Nakata, Takayuki Nagano, Eisuke Okazaki, Katuhiko Noda and Toshiya Masuda : Protection of brain neuronss suffering from oxidative stress by new curcuminoids isolated from Zingiber cassumunar, Natural Science Research, Vol.11, 7-19, 1998. (キーワード) antioxidant
13.	金丸芳, 藤原和子, 宮本悌次郎 : 市販粉ワサビと数種化合物併用による細菌増殖阻害作用, 大阪市立大学生活科学部紀要, Vol.37, 9-13, 1989年.
14.	金丸芳, 高谷友久, 宮本悌次郎 : 市販粉ワサビ，カラシ粉の細菌増殖阻害作用, 大阪市立大学生活科学部紀要, Vol.37, 1-7, 1989年.
15.	田邊幾之助, 金丸芳 : 旧式焼酎の高酸度醪のモデル実験について, 鹿児島大学農学部学術報告, Vol.36, 99-109, 1986年.
16.	田邊幾之助, 二石大介, 金丸芳 : 旧式焼酎酒母・醪から分離した乳酸菌の生態学的性質について, 鹿児島大学農学部学術報告, Vol.34, 45-57, 1986年.
17.	田邊幾之助, 有川順子, 金丸芳, 丸山智之, 佐藤平二 : 高酸度焼酎醪における乳酸菌の蛍光抗体法による検出について, 鹿児島大学農学部学術報告, Vol.33, 53-63, 1983年.

学術レター:

1.	Shoehei Saitoh, Eri Fukunaga, Sari Honda, Kaori Kanemaru, Masaya Satoh and Yasuo Oyama : Nonivamide, a natural analog of capsaicin, affects intracellular Ca2+ level in rat thymic lymphocytes, Natural Science Research, Vol.28, No.3, 15-19, 2014. (要約) Effect of nonivamide, a natural analog of capsaicin, on intracellular Ca2+ level of rat thymocytes was examined using a flow-cytometric technique with appropriate fluorescent probes in order to further characterize the cytotoxicity because nonivamide can be used as an active intergradient of antifouling paints. Nonivamide at concentrations ranging from 30 µM to 300 µM significantly increased the intensity of Fluo-3 fluorescence. The potency of 100 µM nonivamide to increase the fluorescence was similar to that of 100 µM capsaicin. The increase in Fluo-3 fluorescence by 100 µM nonivamide was attenuated under an external Ca2+-free condition. Nonivamide at 100 µM also increased the intensity of Fluo-3 fluorescence in the continued presence of 100 µM capsaicin. It is suggested that nonivamide at high micromolar concentrations increases intracellular Ca2+ level via the activation of vanilloid receptors. Nonivamide concentrations (30 µM or more) that increase intracellular Ca2+ level in rat thymocytes are comparable to those in algal cells. However, it is something hard to argue the implications in environmental science because nonivamide doesn't seem to be released into environment in such a high concentration, and because bioaccumulation of nonivamide has not been reported. (キーワード) Capsaicin / Nonivamide (徳島大学機関リポジトリ) ● Metadata: 106432 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050564287418356224 (徳島大学機関リポジトリ: 106432, CiNii: 1050564287418356224)

総説・解説:

1.	金丸芳, 横井川久己男 : 大腸菌の食品加工・調理器具素材への付着とバイオフィルム形成, クリーンテクノロジー, Vol.28, No.8, 19-21, 2018年8月. (キーワード) 大腸菌 (Escherichia coli) / バイオフィルム (biofilm) (徳島大学機関リポジトリ) ● Metadata: 113898 (徳島大学機関リポジトリ: 113898)
2.	金丸芳, 逵牧子, 横井川久己男 : 食品加工・調理器具への微生物の付着と殺菌剤耐性, 食品機械装置, Vol.53, No.10, 50-55, 2016年10月. (徳島大学機関リポジトリ) ● Metadata: 113902 (徳島大学機関リポジトリ: 113902)

国際会議:

1.	Takahashi Keiko, Matsushita Junko, Ofuku Tsukie, Endo Chizuru, Kaori Kanemaru, Ariuchi Naoko and Tamura Sakie : A Study of Fish-Intake Situation in Tokushima Prefecture, IFHI 2004 Post-Congress on Japanese Food Culture, 65-66, Aug. 2004.
2.	Mtsushita Fumiko, Itakura Kazue, Yokoyama Yae, Ishikawa Yukihiro, Tsunomori Akiko, Nagata Kimiko, Okuno Motoko, Yamamoto Yoshihiro, Esumi Yukiko, Ando Mami, Sakurahi Nahoko, Hanai Reiko, Koda Tomoko, Goto Yoshiko, Kamei Aya, Tuchiya Fusae, Okuda Hiroe, Maeda HIromi, Ohshita Ichiko, Okuyama Kiyomi, Kurata Mie, Miyoshi Yasuyuki, Okamoto Yoko, Kamimura Yoshie, Ikawa Yoshiko, Teramoto Ai, Sasaki Atsuko, Ohno Fumiko, Fujii Kumiko, Takada Marhiko, Fuchigami Michiko, Wada Haruko, Aoki MIeko, Hirano Naoko, Imada Setsuko, Nishizaki Sumiyo, Arimoto Shouzou, Arita Taeko, Hitomi Tetsuko, Kasai Yaeko, Fujii Wakako, Kato Miyuki, Kawasome Setsue, Akiyama Teruko, Udaka Junko, Mine Hiroko, Takeda Tamami, Kawabata Kazuko, Shigematu Kumi, Uyama Hiroko, Kaori Kanemaru, Tamura Sakie, Shibayama Kiyoko and Morioka Miho : The Dietary Habit of Soybeans and their Processed Products in the Chugoku and the Shikoku Areas -A Comparison between the Early Showa Era and the Present-, IFHE 2004 Post-Congress on Japanese Food Culture, 29-30, Aug. 2004.
3.	Hideyuki Nakagawa, Hitomi Sakai, Kaori Kanemaru and Hiromi Hayashi : A sea urchin lectin, SUL-I induces differentiation on murine myeloid leukemic cells, GRC on Marine Natural Products, Ventura, California, Feb. 2004. (要約) ラッパウニ叉棘から精製されたD-galactose binding lectin のSUL-I はマウス由来のmyeloid leikemic cell をマクロファージ様に分化誘導し，部分的なアポトーシスを引き起こした． (キーワード) マウス骨髄性白血病細胞 / 分化 (differentiation) / Dーガラクトース結合性レクチン / ウニレクチン / ラッパウニ

国内講演発表:

1.	山﨑義輝, 山下晶央, 佐々木千鶴, 林順司, 川上竜巳, 金丸芳 : 鳴門産スジアオノリ(Ulva prolifera)の志賀毒素吸着活性, 日本農芸化学会中四国支部第64 回講演会要旨集, 2023年1月. (キーワード) E. coli O157 / Siga Toxin / Ulva prolifera / adsorption
2.	山下晶央, 山﨑義輝, 佐々木千鶴, 林順司, 川上竜巳, 金丸芳 : アラメ(Eisenia bicyclis)によるEHEC O157 産生志賀毒素吸着, 日本農芸化学会中四国支部大会講演要旨集, 37, 2022年9月. (キーワード) E. coli O157 / Siga Toxin / Eisenia bicyclis / adsorption
3.	佐々木千鶴, 新居美香, 林順司, 金丸芳 : ワカメ非可食部の資源化を目的とした連続水熱処理による有用物質生産法の開発, 日本食品工学会2022年度大会, 岡山, 2022年9月.
4.	三木章江, 高橋啓子, 後藤月江, 川端紗也花, 長尾久美子, 松下純子, 坂井真奈美, 近藤美樹, 金丸芳 : 徳島県の家庭料理地域の特徴ー地域で親しまれてきた料理ー, 日本調理科学会2022年度大会研究発表要旨集, 2022年9月. (キーワード) 徳島 / 家庭料理 / 主食・主菜・副菜・汁物・おやつ
5.	Rumana Yesmin Hasi, Naohiro Imura, Toshiki Ishikawa, Hiroyuki Imai, Yoshimichi Takai, Hanif Ali, Mutsumi Aihara, Junji Hayashi, Ryushi Kawakami, Kaori Kanemaru and Tamotsu Tanaka : Distribution and characterization of glycosylinositol phosphoceramide specific phospholipase D in Brassica plants, 第64回日本脂質生化学会, Vol.64, 272-275, Jun. 2022.
6.	Hanif Ali, Miyu Kobayashi, Katsuya Morito, Rumana Yesmin Hasi, Mutsumi Aihara, Junji Hayashi, Ryushi Kawakami, Kaori Kanemaru, Koichiro Tsuchiya, Kazunori Sango and Tamotsu Tanaka : Peroxisomes attenuate lipotoxicity of very-long-chain fatty acids, 第64回日本脂質生化学会, Vol.64, 43-46, Jun. 2022.
7.	Hanif Ali, Miyu Kobayashi, Katsuya Morito, Rumana Yesmin Hasi, Mutsumi Aihara, Junji Hayashi, Ryushi Kawakami, Kaori Kanemaru, Koichiro Tsuchiya, Kazunori Sango and Tamotsu Tanaka : Metabolism and biological effect of very-long-chain fatty acid in peroxisome-deficient cells, 第63回日本生化学中国・四国支部例会, May 2022.
8.	Hanif Ali, Katsuya Morito, Rumana Yesmin Hasi, Mutsumi Aihara, Junji Hayashi, Ryushi Kawakami, Kaori Kanemaru, Koichiro Tsuchiya, Kazunori Sango and Tamotsu Tanaka : Characterization of uptake and metabolism of very-long-chain fatty acid in peroxisome-deficient CHO cells, 第94回日本生化学大会, Nov. 2021.
9.	Rumana Yesmin Hasi, Naohiro Imura, Toshiki Ishikawa, Hiroyuki Imai, Yoshimichi Takai, Hanif Ali, Mutsumi Aihara, Junji Hayashi, Ryushi Kawakami, Kaori Kanemaru and Tamotsu Tanaka : Production of phytoceramide 1- phosphate and inositol glycan by glycosylinositol phosphoceramide specific phospholipase D activity in plants, 第94回日本生化学大会, Nov. 2021.
10.	Hanif Ali, Katsuya Morito, Rumana Yesmin Hasi, Mutsumi Aihara, Junji Hayashi, Ryushi Kawakami, Kaori Kanemaru, Koichiro Tsuchiya, Kazunori Sango and Tamotsu Tanaka : Characterization of uptake and metabolism of very-long-chain fatty acid in peroxisome-deficient CHO cells, 第62回日本生化学中国・四国支部例会, Sep. 2021.
11.	Rumana Yesmin Hasi, Naohiro Imura, Toshiki Ishikawa, Hiroyuki Imai, Yoshimichi Takai, Hanif Ali, Mutsumi Aihara, Junji Hayashi, Ryushi Kawakami, Kaori Kanemaru and Tamotsu Tanaka : Production of phytoceramide 1- phosphate and inositol glycan by glycosylinositol phosphoceramide specific phospholipase D activity in plants, 第62回日本生化学中国・四国支部例会, Sep. 2021.
12.	高橋啓子, 三木章江, 宇野美和子, 川端紗也花, 後藤月江, 長尾久美子, 松下純子, 近藤美樹, 坂井真奈美, 金丸芳 : 徳島県の家庭料理行事食の特徴 -ひな祭りの楽しい思い出-遊山箱―, 日本調理科学会2021年度大会, 2021年9月.
13.	Hanif Ali, Katsuya Morito, Rumana Yesmin Hasi, Mutsumi Aihara, Junji Hayashi, Ryushi Kawakami, Kaori Kanemaru, Koichiro Tsuchiya and Tamotsu Tanaka : Uptake and metabolism of very-long-chain fatty acid in animal cells, 第63回日本脂質生化学会, Jun. 2021.
14.	Rumana Yesmin Hasi, Yoshimichi Takai, Hanif Ali, Kentaro Kogure, Junji Hayashi, Ryushi Kawakami, Mutsumi Aihara, Kaori Kanemaru and Tamotsu Tanaka : Isolation of glycosylinositol phosphoceramide and phytoceramide 1-phosphate from cabbage leaves and their chemical stabilities., 日本農芸化学会2020年度中四国支部大会(第57回講演会), Sep. 2020.
15.	山下晶央, 山﨑義輝, 金丸芳 : STEC O157:H7 産生志賀毒素の分離と細胞毒性, 日本農芸化学会2020年度中四国支部大会, 40, 2020年9月.
16.	山﨑義輝, 山下晶央, 金丸芳 : 固定化グルタミン酸(Glutamate-Sepharose)の志賀毒素吸着, 日本農芸化学会2020年度中四国支部大会, 40, 2020年9月.
17.	Rumana Yesmin Hasi, Dai Majima, Katsuya Morito, Hanif Ali, Kentaro Kogure, Junji Hayashi, Ryushi Kawakami, Kaori Kanemaru, Meera Nanjundan, Toshiki Ishikawa and Tamotsu Tanaka : Methods for isolation of glycosylinositol phosphoceramide and phytoceramide 1-phosphate from plant tissues., 第93回日本生化学大会, Sep. 2020.
18.	Rumana Yesmin Hasi, Dai Majima, Katsuya Morito, Hanif Ali, Kentaro Kogure, Junji Hayashi, Ryushi Kawakami, Kaori Kanemaru, Meera Nanjundan, Toshiki Ishikawa, Hiroyuki Imai and Tamotsu Tanaka : Development of methods for isolation of glycosylinositol phosphoceramide and phytoceramide 1-phosphate from plant tissues., 第62回日本脂質生化学会, May 2020.
19.	金丸芳 : ポリ-γ-グルタミン酸の志賀毒素吸着と CACO-2細胞への影響, 第40回日本食品微生物学会学術総会講演要旨集, 2019年11月.
20.	田中保, Rumana Hasi Yesmin, 森戸克弥, 小暮健太朗, 林順司, 川上竜巳, 金丸芳, 今井博之, 石川寿樹 : グリコシルイノシトールホスホセラミドの単離法の開発, 第12回セラミド研究会学術集会, 2019年10月.
21.	田中保, 森戸克弥, Rumana Hasi Yesmin, 林順司, 川上竜巳, 金丸芳, 若山睦, 近藤千恵子, 福田達也, 小暮健太朗 : 食品素材に含まれるセラミドの簡便な定量方法, 日本脂質栄養学会第28回大会, 2019年9月.
22.	長尾久美子, 坂井真奈美, 松下純子, 近藤美樹, 後藤月江, 三木章江, 高橋啓子, 川端沙也花, 金丸芳 : 徳島県の家庭料理副菜の特徴∼食材から見える地域性∼, 日本調理科学会2019年度大会研究発表要旨集, 2019年8月.
23.	酒井仁美, 金丸芳, 酒井徹, 横井川久己男 : 調理器具素材への大腸菌の付着を抑制する小麦粉の成分の同定, 第39回日本食品微生物学会総会, 2018年9月.
24.	金丸芳, 酒井仁美, 高橋啓子, 横井川久己男 : ガラス表面に付着した大腸菌の洗浄と殺菌, 第39回日本食品微生物学会学術総会講演要旨集, 111, 2018年9月. (キーワード) バイオフィルム (biofilm) / 大腸菌 (Escherichia coli)
25.	丸谷永一, 金丸芳, 清水正明, 藤本武 : 徳島県産「タデ藍」を活用した鶏肉商品価値を高める魚粉飼料給与技術の確立, 平成30年度第68回関西畜産学会大会(徳島大会)講演要旨集, 15, 2018年9月.
26.	金丸芳, 坂井真奈美, 松下純子, 長尾久美子, 近藤美樹, 後藤月江, 三木章江, 川端紗也花, 髙橋啓子 : 徳島県の家庭料理主菜の特徴地場食材を用いた主菜, 一般社団法人日本調理科学会平成30年度大会，西宮研究発表要旨集, 97, 2018年8月.
27.	川上竜巳, 金丸芳, 横井川久己男 : 食品微生物や発酵食品に含まれるD-アミノ酸検出のためのUHPLC検出系の構築, 第38回日本日本食品微生物学会学術総会, 2017年10月.
28.	Badr Ali Hoida, Takahashi Keiko, Ryushi Kawakami, Yasuo Oyama, Kumio Yokoigawa and Kaori Kanemaru : Screening and analysis of edible seaweeds in the ability to adsorb Shiga toxin, 第38回日本日本食品微生物学会学術総会, Oct. 2017.
29.	後藤月江, 金丸芳, 横井川久己男 : 固定化ポリーγーグルタミン酸の志賀毒素吸着性, 第38回日本食品微生物学会学術総会, 2017年10月.
30.	後藤月江, 三木章江, 川端沙也花, 高橋啓子, 坂井真奈美, 松下純子, 長尾久美子, 近藤美樹, 金丸芳 : 徳島県の家庭料理おやつの特徴ー地域で親しまれてきたおやつ-, 日本調理科学会平成29年度大会研究発表要旨集, 101, 2017年8月.
31.	生杉笙, 金丸芳, 横井川久己男, 小山保夫 : 徳島県産食用植物クサギClerodendrum trichotomunのガン細胞増殖抑制, 日本農芸化学会中国四国支部第48回講演会講演要旨, 33, 2017年6月.
32.	横井川久己男, 高橋啓子, 金丸芳 : 非生物素材に付着した大腸菌O157のバイオフィルム形成, 日本農芸化学会2017大会, 2017年3月.
33.	金丸芳, 生杉笙, 川上竜巳, 小山保夫, 横井川久己男 : 徳島県産食用植物のガン細胞増殖抑制, 日本農芸化学会2017年度(平成29年度)大会講演要旨集, 2017年3月.
34.	横井川久己男, オワイダアリバドル, 金丸芳 : 食用海藻の志賀毒素吸着性, 第37回日本食品微生物学会学術総会講演要旨集, 64, 2016年9月.
35.	後藤月江, 逵牧子, 金丸芳, 横井川久己男 : 沈殿したポリ-γ-グルタミン酸の志賀毒素吸着性, 日本農芸化学会中四国支部第45回講演会要旨集, 24, 2016年6月.
36.	高橋啓子, 服部武文, 金丸芳, 小山保夫, 横井川久己男 : Tricholoma matsutake 菌糸生育におけるD-及びL-アミノ酸の添加効果, 日本農芸化学会中四国支部第45回講演会要旨集, 36, 2016年6月.
37.	オワイダアリバドル, 金丸芳, 横井川久己男 : Screening and analysis of edible seaweeds in the ability to adsorb Shiga toxin, 日本農芸化学会中四国支部第45回講演会要旨集, 23, 2016年6月.
38.	金丸芳, 高橋啓子, 後藤月江, 三木章江, 長尾久美子, 近藤美樹, 松下純子 : 次世代に伝え継ぐ日本の家庭料理ー徳島県の聞き書き調査から・おかずー, 一般社団法人日本調理科学会平成27年度大会研究発表要旨集, 28, 2015年8月.
39.	高橋啓子, 後藤月江, 三木章江, 金丸芳, 長尾久美子, 近藤美樹, 松下純子 : 次世代に伝え継ぐ日本の家庭料理ー徳島県の聞き書き調査からー, 一般社団法人日本調理科学会平成26年度大会研究発表要旨集, 86, 2014年8月.
40.	松家憲子, 山口智美, 葵義民, 三枝貴代, 金丸芳 : 乳酸菌発酵米の肥育豚に対する給与効果の検討, 第63回四国地区獣医師大会・平成24年度獣医学術四国地区学会・日本産業動物学会(四国)・日本小動物学会(四国)・日本獣医公衆衛生学会(四国), 2012年9月.
41.	金丸芳, 遠藤千鶴, 高橋啓子, 松下純子, 後藤月江, 武田珠美, 長尾久美子, 有内尚子 : 徳島県における行事食・儀礼食の現状について –地域別比較-, 日本調理科学会平成24年度大会, 2012年8月.
42.	松下純子, 武田珠美, 後藤月江, 遠藤千鶴, 高橋啓子, 有内尚子, 長尾久美子, 金丸芳 : 徳島県における行事食の現状について(2) 人日から大みそかおよび春祭り・秋祭り(正月を除く), 日本調理科学会平成23年度大会, 2011年8月.
43.	高橋啓子, 金丸芳, 後藤月江, 遠藤千鶴, 有内尚子, 長尾久美子, 松下純子, 武田珠美 : 徳島県の行事食の現状についてー正月料理・通過儀礼ー, 日本調理科学会平成23年度大会, 2011年8月.
44.	松浦(三木) 宏美, 金丸芳, 山本済人, 岩田深也 : 鳴門金時(Ipomoea batatas)茎葉部の食品機能性, 日本農芸化学会中四国支部第22回講演会(2008年度支部大会)講演要旨集, 39, 2008年9月.
45.	三木宏美, 田中芙美佳, 金丸芳, 山本澄人, 岩田深也, 柏岡静, 阿佐章, 田中道夫, 近藤雅勝, 坂東弘康, 大田昌平 : SKゴールド(飼料混合用納豆菌製剤)の機能性, 日本農芸化学会中四国支部第20回講演会講演要旨集, 29, 2008年1月.
46.	金丸芳, 三木宏美, 井田貴子, 山本澄人, 岩田深也, 有井俊介, 仲野孝弘 : 鳴門金時の食品機能性, 日本農芸化学会2007年度中四国・西日本支部合同大会講演要旨集, 45, 2007年9月.
47.	金丸芳, 三木宏美, 井田貴子, 松本哲治, 林弘三, 小山保夫 : カフェ酸とクロロゲン酸の機能性の比較, 49, 2006年9月.
48.	杉本眞由美, 中川秀幸, 林弘三, 小山保夫, 増田俊哉, 金丸芳 : ヒジキのガン細胞増殖抑制, 日本農芸化学会2005年度関西・中四国・西日本支部合同大会講演要旨集, 38, 2005年9月.
49.	高橋啓子, 松下純子, 後藤月江, 遠藤千鶴, 金丸芳, 有内尚子, 田村咲江 : 徳島県における魚食の現状, 89, 2005年9月.
50.	金丸芳, 杉本眞由美, 横井川久己男, 山本澄人, 岩田深也, 柏岡静, 阿佐章, 板東弘康, 大田昌平 : 納豆菌発酵オカラの機能性, 日本食品科学工学会第52回大会講演集, 123, 2005年8月.
51.	國永真妃, 金丸芳, 小山保夫, 酒井仁美, 中川秀幸, 林弘三 : 香辛料成分によるマウスメラノーマに対する増殖抑制, 2004年度日本農芸化学会中国四国支部大会講演要旨集, 19, 2004年9月.
52.	中川秀幸, Fumihiko Satoh, Yuuko Aguro, Takeshi Hosotani, Ai Yukata, 金丸芳, Kuniko Nagasaka, Toshinori Nagasaka, Mitsuko Shinohara, Tadashige Nozaki, Kiyoshi Ohura : Purification of a dorsal lectin from the redfin velvetfish, Hypodytes rubripinnis, Journal of Pharmacological Sciences, Vol.94, No.Supplement 1, 135p, 2004年3月. (要約) A novel lectin was isolated from the dorsal venom of H. rubripinnis by affinity chromatography and tested for mitogenicity. It showed a single protein band with a molecular mass of 120 kDa.
53.	篠山優也, 金丸芳, 小山保夫, 林弘三 : シンナムアルデヒドのガン細胞増殖抑制, 平成15年度日本農芸化学会西日本支部，中四国支部．日本栄養·食糧学会西日本支部，日本食品科学工学会西日本支部鹿児島合同大会およびシンポジウム, 2003年9月. (キーワード) 増殖抑制 / ガン細胞 / シンナムアルデヒド
54.	金丸芳, 福田亜紀, 中川秀幸, 林弘三, 野田克彦, 小山保夫 : カフェ酸類似体の細胞保護作用とDPPHラジカル消去活性との比較, 日本農芸化学会2003年度大会, 2003年4月.
55.	金丸芳, 津田貴美, 谷本桃代 : 香辛料成分によるガン細胞増殖阻害, 日本農芸化学会2002年度中四国支部大会講演要旨集, 54, 2002年9月.
56.	金丸芳, 谷本桃代, 津田貴美, 中川秀幸, 林弘三, 野田克彦, 増田俊哉, 小山保夫 : H2O2傷害に対するカフェ酸の胸腺細胞保護作用, 日本農芸化学会2002年度大会, 2002年3月.
57.	金丸芳, 中川秀幸, 林弘三, 野田克彦, 小山保夫, 増田俊哉 : 食品由来成分の細胞に対する生理機能作用, 日本農芸化学会2001年度関西·中国·四国支部合同大会, 2001年10月.
58.	金丸芳, 工野良子, 小西ユカリ, 酒井仁美, 小山保夫, 中川秀幸, 林弘三, 野田克彦 : H2O2障害に対するヒジキの胸腺細胞保護作用, 日本食品科学工学会第48回大会, 2001年9月.
59.	金丸芳, 小西ユカリ, 工野良子, 佐藤征弥, 小山保夫, 林弘三, 酒井仁美, 中川秀幸, 野田克彦 : ガン細胞増殖抑制活性を有する海藻の検索, 日本農芸化学会2001年度大会, 2001年3月.
60.	金丸芳, 越智未来, 管木薫子, 佐藤征弥 : 海藻によるガン細胞増殖阻害作用, 日本農芸化学会2000年度大会, 2000年4月.
61.	小山保夫, 山崎優子, 船井めぐみ, 岡田栄彦, 金丸芳 : ラット胸腺細胞に対するトリブチル錫の及ぼす影響-アネキシン V-FITCとエチジウムを用いる細胞毒性評価-, 日本薬理雑誌(第52回日本薬理学会西南支部会), Vol.115, No.3, 1999年11月.
62.	中川秀幸, 沖田健宏, 酒井仁美, 金丸芳, 林弘三 : ウニ叉棘レクチンのマイトジェン活性と細胞障害性, 生化学(第72回日本生化学会大会発表抄録集), Vol.71, No.8, 846, 1999年10月.
63.	佐藤征弥, 布野敬子, 山崎慎介, 金丸芳 : ストレス処理により分泌される褐藻類ヒジキの生理活性物質について, 日本植物学会第63回大会, 1999年10月.
64.	佐藤征弥, 布野敬子, 梯麻美子, 唐木恵美, 金丸芳 : 褐藻類ヒジキにおけるストレス処理による分泌物の性質について, 日本藻類学会第23回大会, 1999年3月.
65.	小山保夫, 梶田紀子, 中田真美, 山崎優子, 船井めぐみ, 野口さち, 金丸芳, 近久ルミ : バリノマイシンのK562細胞増殖抑制作用, 日本薬理学雑誌(第51回日本薬理学会西南部会), Vol.113, No.3, 68, 1998年11月.
66.	金丸芳 : 香辛料の細胞保護作用ならびにガン細胞および細菌増殖阻害作用, 第13回日本香辛料研究会, 1998年11月.
67.	金丸芳, 柴田真美子, 鈴木恵美, 富吉冨貴代, 野田克彦, 小山保夫 : 香辛料によるガン細胞増殖阻害作用, 第52回日本栄養·食糧学会大会, 1998年4月.
68.	金丸芳, 鈴木恵美, 柴田真美子, 林弘三, 野田克彦, 小山保夫 : 酸化ストレスに対する香辛料の細胞保護作用, 日本農芸化学会1998年度大会, 1998年4月.
69.	小山保夫, 中田真美, 梶田紀子, 近久ルミ, 岡崎英佐, 金丸芳, 増田俊哉 : 新規クルクミノイドの酸化ストレスに対する細胞保護作用, 日本薬理学雑誌(第50回日本薬理学会西南部会), Vol.111, No.2, 83, 1997年11月.
70.	中川秀幸, 山口知栄子, 金丸芳, 林弘三, 富原靖博, 新城安哲 : ウニ類の毒棘および叉棘レクチンによるマイトジェン活性, 111, 1996年10月.
71.	富吉冨貴代, 金丸芳, 林弘三, 大橋真 : 低蛋白食投与マウスのPlasmodium berghei感染抵抗性と免疫担当細胞の変動, 第47回日本栄養・食糧学会総会講演要旨集, 204, 1993年5月.
72.	富吉冨貴代, 金丸芳, 大橋真, 林弘三, 喜来伸江, 山下正恵 : マウスのPlasmodium bergheiに対する抵抗性への飼料タンパク質量の影響, 第25回日本栄養・食糧学会中国・四国支部大会抄録集, 14, 1992年11月.
73.	金丸芳 : クローブによる数種糸状菌の増殖抑制とそれに及ぼす水分活性の影響, 第25回日本栄養・食糧学会中国・四国支部大会抄録集, 11, 1992年11月.
74.	金丸芳, 枡本有紀子, 宮本悌次郎 : ブラウンマスタードと酢酸併用時の食品中微生物増殖阻害, 日本食品工業学会第39回大会講演集, 100, 1992年3月.
75.	金丸芳, 渡邊容子, 宮本悌次郎 : 香辛料による糸状菌の増殖抑制とそれに及ぼす湿度の影響, 日本調理科学会平成3年度大会研究発表要旨集, 15, 1991年9月.
76.	金丸芳, 南佳子, 宮本悌次郎 : ブラウンマスタードの数種食品中の微生物増殖阻害, 第45回日本栄養・食糧学会総会講演要旨集, 36, 1991年5月.
77.	川島文恵, 金丸芳, 宮本悌次郎 : Allylisothiocyanateの細菌増殖阻害に及ぼす食品成分の影響, 日本食品工業学会第38回大会講演集, 137, 1991年3月.
78.	金丸芳, 熊村信美, 宮本悌次郎 : クローブおよびマスタードの鶏レバー中微生物増殖抑制, 第44回日本栄養・食糧学会総会講演要旨集, 227, 1990年5月.
79.	金丸芳, 藤井玲子, 高谷友久, 宮本悌次郎 : クローブによる細菌プロテアーゼ阻害, 日本農芸化学会誌 (日本農芸化学会1990年度大会講演要旨集p.233), Vol.64, No.3, 541, 1990年3月.
80.	金丸芳, 辻本順子, 宮本悌次郎 : ブラウンマスタードとアリルイソチオシアネートの微生物増殖阻害作用, 日本食品工業学会第36回大会講演集, 96, 1989年5月.
81.	金丸芳, 森田恵都子, 宮本悌次郎 : 香辛料添加による食品中の細菌増殖阻害作用, 第43回日本栄養・食糧学会総会講演要旨集, 128, 1989年5月.
82.	金丸芳, 藤原和子, 高谷友久, 宮本悌次郎 : ブラウンマスタードの細菌増殖阻害, 日本農芸化学会昭和63年度大会講演要旨集, 441, 1988年4月.
83.	金丸芳, 高谷友久, 宮本悌次郎 : ワサビ，カラシ及びシナモンの細菌増殖阻害, 日本農芸化学会昭和62年度大会講演要旨集, 550, 1987年4月.
84.	金丸芳, 高谷友久, 宮本悌次郎 : スパイスの精油主成分定量法の検討と細菌増殖阻害作用, 日本農芸化学会昭和61年度大会講演要旨集, 6, 1986年11月.
85.	金丸芳, 高谷友久, 宮本悌次郎 : スパイス類とその成分の細菌増殖阻害, 日本農芸化学会昭和61年度大会講演要旨集, 576, 1986年4月.
86.	金丸芳, 宮本悌次郎 : スパイス類の細菌増殖阻害, 日本農芸化学会昭和60年度大会講演要旨集, 90, 1985年7月.
87.	田邊幾之助, 金丸芳, 二石大介 : 高酸度焼酎醪のモデル実験としての乳酸菌と酵母の混合培養, 日本農芸化学会誌, Vol.57, No.12, 103, 1983年.

報告書:

1.	高橋啓子, 金丸芳, 後藤月江, 松下純子, 長尾久美子, 近藤美樹, 三木章江 : 特別研究平成24∼25年度『次世代に伝え継ぐ日本の家庭料理』聞き書き調査報告 36. 徳島県, 平成24∼25年度『次世代に伝え継ぐ日本の家庭料理』聞き書き調査報告書, 421-429, 2014年6月.
2.	松家憲子, 山口智美, 堀北直樹, 先川正志, 金丸芳, 新居雅宏 : 乳酸菌発酵飼料米を利用したプロバイオティクス飼料の開発, 徳島県立農林水産総合技術支援センター畜産研究所研究報告, Vol.12, No.12, 23-30, 2013年3月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050845763683961216 (CiNii: 1050845763683961216)
3.	金丸芳, 後藤月江, 松下純子, 高橋啓子, 遠藤千鶴, 武田珠美, 長尾久美子, 有内尚子 : 徳島県における行事食・儀礼食の現状, 日本調理科学会中国・四国支部創立40周年記念誌, 52-55, 2013年.
4.	遠藤千鶴, 高橋啓子, 後藤月江, 有内尚子, 松下純子, 長尾久美子, 武田珠美, 金丸芳 : 平成22年度調理科学会特別研究「行事食・儀礼食」調査報告(徳島県), 平成21∼23年度日本調理科学会特別研究「調理文化の地域性と調理科学」報告書 -行事食・儀礼食-, 146-147, 2011年2月.
5.	金丸芳 : 乾燥発酵オカラの機能性評価, オカラを原料とする飼料の高品質化に関する研究・研究報告書(平成16年度徳島県新産業創出総合支援事業中核4分野研究調査事業・社団法人発明協会徳島県支部), 7-11, 2005年.
6.	有内尚子, 遠藤千鶴, 大福月江, 金丸芳, 高橋啓子, 田村咲江, 松下純子, 山田和子 : 「調理文化の地域性と調理科学 -魚介類-」報告書(徳島県), 平成15・16年度日本調理科学特別研究「調理文化の地域性と調理科学」報告書 -魚介類の調理-, 197-203, 2004年.
7.	金丸芳 : 徳島の「いも類・豆類」の料理, 日本調理科学会中国・四国支部創立30周年記念誌, 46-49, 2003年.
8.	金丸芳 : ガン細胞増殖抑制活性を有する海草成分の検索, 浦上財団研究報告書(平成12年度財団法人浦上・食文化振興財団研究助成), Vol.10, 44-53, 2002年.
9.	金丸芳, 田村咲江, 宇山裕子 : 「豆・いも類利用の地域特性」報告書(徳島県), 平成13・14年度日本調理科学特別研究「調理文化の地域性と調理科学」報告書 -豆・いも類利用の地域性-, 215-217, 2002年.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

難消化性食品成分によるO157志賀毒素の吸着除去 (研究課題/領域番号: 21K02092 )
難消化性食品成分の志賀毒素の吸着性 (研究課題/領域番号: 18K02204 )
貝類に蓄積しているトリブチル錫などの有機錫の多様な毒性の解析 (研究課題/領域番号: 12680544 )
研究者番号（00243676）による検索

教授, 准教授, 講師 : 金丸芳

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科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

教授, 准教授, 講師 : 金丸 芳

研究活動

個人のホームページ

専門分野

研究テーマ

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著書:

学術論文(審査論文):

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国際会議:

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科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

教授, 准教授, 講師 : 金丸芳