Tissue-specific Autoimmunity Controlled by Aire, a Gene Responsible for APECED

The 3rd International Congress on Rare Diseases


Characterization of Aire-expressing DCs with high-sensitivity and high-fidelity Aire-reporter strain

The 48th Annual Meeting of the Japanese Society for Immunology


Aire-dependent establishment of self-tolerance

The 17th International Congress of Immunology


Tissue-specific autoimmunity controlled by Aire in thymic and peripheral tolerance mechanisms

The 18th Awaji International Forum on Infection and Immunity


Aire-dependent establishment of self-tolerance studied by genetically modified mice


Tissue-specific autoimmunity modified by Aire in thymic and peripheral tolerance

5th International Congress on Controversies in Rheumatology and Autoimmunity (CORA)


Tissue-specific autoimmunity manipulated by Aire in thymic and peripheral tolerance

Immunology of Diabetes Society Congress 2018


Aire controls in trans the production of medullary thymic epithelial cells expressing Ly6C/Ly6G

5th European Congress of Immunology 2018


Distinct tissue-specific immune response revealed by manipulation of thymic and peripheral tolerance by Aire

1st International Symposium for "Neo-self"


Manipulation of thymic and peripheral tolerance by AIRE defines distinct tissue-specific autoimmunity

11th International Congress on Autoimmunity


Expression of Ly6C/6G defines a novel subset of medullary thymic epithelial cells


A novel Aire-dependent subset of mTECs with tolerogenic functions is defined by Ly6 family protein expression


Acquisition of the resistance to autoimmune diabetes by the expression of human AIRE in BM-derived APCs in NOD


5th Annual Meeting of the International Cytokine and Interferon Society


Expression of Ly6C/6G defines a novel Aire-dependent subset of medullary thymic epithelial cells with tolerogenic function


Paradoxical development of polymyositis-like autoimmunity through augmented expression of AIRE

7th International Workshop of Kyoto T Cell Conference


Paradoxical development of polymyositis-like autoimmunity through augmented expression of human AIRE in mice

Controversies in Rheumatology and Autoimmunity 2017


Massive infiltration of macrophages and eosinophils in the muscle of mice overexpressing Aire in thymic and peripheral antigen-presenting cells

Cell Symposia - 100 Years of Phagocytosis


Augmented expression of the autoimmune regulator (AIRE) induces paradoxical development of polymyositis-like autoimmunity


Augmented expression of the autoimmune regulator (AIRE) induces paradoxical development of polymyositis-like autoimmunity in mice

The Fifth Bizan Immunology Symposium at University of Tokushima


Aire expression is inherent to all medullary thymic epithelial cells during their differentiation program


Aire expression is inherent properties of all medullary thymic epithelial cells during their differentiation program


Unexpected disturbance of the development of medullary thymic epithelial cells at immature stages by the long-term ablation of Aire-expressing cells

Controversies in Rheumatology and Autoimmunity 2015


Ectopic Aire expression in thymic cortex reveals inherent properties of Aire as a medullary stromal factor

European Society for Immunodeficiencies 2014


Ectopic Aire expression in thymic cortex reveals inherent properties of Aire as a stromal factor for medullary thymic microenvironment

9th International Symposium of the Institute Network


Ectopic Aire expression in thymic cortex reveals inherent properties of Aire as a stromal factor for medullary microenvironment

9th International Congress on Autoimmunity


Ectopic Aire expression in thymic cortex reveals inherent properties of Aire as a stromal factor within medullary microenvironment

第3回 眉山免疫シンポジウム

第3回 眉山免疫シンポジウム


Aire-dependent organization of thymic microenvironment for the establishment of self-tolerance


Temporal lineage tracing of Aire-expressing cells reveals a requirement of Aire for their maturation program


Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program

The 6th International Workshop of Kyoto T Cell Conference


Temporal fate-mapping study reveals essential roles of Aire in the maturation program of Aire-expressing cell lineage


Temporal lineage tracing of Aire-expressing cells reveals a requirement of Aire for their full maturation program

Controversies in Rheumatology and Autoimmunity (CORA 2011)


Essential roles of Aire in the maturation program of Aire-expressing cell lineage(s) revealed by temporal fate-mapping approach

The 10th International Conference on New Trends in Immunosuppression and Immunotherapy


2013 SKKU International Symposium on Molecular Medicine: New Trends in Cancer and Autoimmunity Research


Control of chronic inflammation through elucidation of organ-specific autoimmune disease mechanisms


Aire-dependent organization of thymic microenvironment for the establishment of self tolerance


Temporal fate-mapping approach reveals a requirement of Aire for the full maturation program of thymic epithelial cells in the medulla

International Symposium on Genetic and Epigenetic Control of Cell Fate


Temporal fate-mapping reveals essential roles of Aire in the maturation program of mTECs


Functional analysis of Aire, a gene responsible for the hereditary type of autoimmune disease


Aire controls organization of thymic microenvironment for the establishment of self tolerance


Roles of Aire in thymic epithelial cells in the medulla for the establishment of self-tolerance

The Federation of Clinical Immunology Societies (FOCiS) 2012


AIRE-dependent organization of thymic microenvironment for the establishment of self tolerance

5th Congress of the Federation of Immunological Societies of Asia Oceania


Cell-cycle dependent phosphorylation of AIRE protein exogenously expressed in HeLa cells

4th International Conference on Drug Discovery & Therapy


The 4th symposium for the mext priority research on Immunological Self


Expression of Aire, a gene responsible for autoimmune disease, in ES cells

Cell Symposia: Stem Cell Programming & Re-programming


Role of self-antigen expressed by Aire-expressing cells in the negative selection process

5th International Conference on Autoimmunity: Mechanisms and Novel Treatments


Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma

13th International TNF Conference, TNF 2011


Role of Aire in the organization of thymic microenvironment

Controversies in Rheumatology and Autoimmunity (CORA 2011)


Aire-dependent organization of thymic microenvironment for the establishment of self-tolerance

Cutting Edge Immunology and its Clinical Application


Roles of thymic epithelial cells for the establishment of self-tolerance

14th International Congress of Immunology


Aire in thymic epithelial cells in the medulla controls developmental process of thymocytes


Biphasic Aire expression in early embryos and in medullary thymic epithelial cells prior to end-stage terminal differentiation


Expression of Aire, a histone-binding module for H3K4me0, in ES cell

Cold Spring Harbor Asia Conferences, Epigenetics, Chromatin & Transcription


7th International Congress on Autoimmunity


The 19th International Rheumatology Symposium


Nucling, a novel stress-sensitive protein, regulates NF-kappa B activation

The 4th International Congress on Stress Responses in Biology and Medicine, The 4th Annual Meeting of the Biomedical Society for Stress Response

Stress Responses in Biological and Medicine, The Biomedical Society for Stress Response


Aire-dependent organization of thymic microenvironment


Roles of NIK in thymic epithelial cells for the establishment of central tolerance.


Function of Two Arginine Residues of L-Lactate Oxidase

The 3rd International Conference on Oxygenases


胸腺癌におけるAIRE発現と胸腺髄質上皮細胞との類似性

胸腺癌におけるAIRE発現と胸腺髄質上皮細胞との類似性

Proceedings of the Japanese Society of Pathology


胸腺癌におけるAIRE発現と胸腺髄質上皮細胞との類似性

胸腺癌におけるAIRE発現と胸腺髄質上皮細胞との類似性


Aire controls heterogeneity of medullary thymic epithelial cells for the expression of self-antigens

第50回日本免疫学会学術集会

第50回日本免疫学会学術集会


Aire suppresses CTLA-4 expression from medullary thymic epithelial cells to avoid autoimmunity.

第50回日本免疫学会学術集会

第50回日本免疫学会学術集会


Aireレポーターマウスを用いた胸腺内Aire発現樹状細胞の解析

Aireレポーターマウスを用いた胸腺内Aire発現樹状細胞の解析


AIRE発現樹状細胞の機能解析

AIRE発現樹状細胞の機能解析

第109回日本病理学会総会

第109回日本病理学会総会


ヒトAIREトランスジェニックマウスに認めた糖尿病抵抗性獲得機構の解析

ヒトAIREトランスジェニックマウスに認めた糖尿病抵抗性獲得機構の解析

第109回日本病理学会総会

第109回日本病理学会総会


Functional and transcriptomic analysis of medullary thymic epithelial cells with augmented Aire expression

Aireを高発現する胸腺髄質上皮細胞の免疫学的機能とトランスクリプトーム解析

第42回日本分子生物学会年会

第42回日本分子生物学会年会


Antigen Transfer from thymic epithelial cells to DCs contributes to the production of thymic Tregs.

The 48th Annual meeting of the Japanese Society for Immunology


Treg誘導に 関与する胸腺内樹状細胞サブセットとAireの機能解析

Treg誘導に 関与する胸腺内樹状細胞サブセットとAireの機能解析

第2回若手の会(新学術領域ネオセルフの生成・機能・構造)(静岡)

第2回若手の会(新学術領域ネオセルフの生成・機能・構造)(静岡)


Transcriptomic analysis of medullary thymic epithelial cells with augmented Aire expression

第47回日本免疫学会学術集会

第47回日本免疫学会学術集会


Analysis of the role of thymic APCs and Aire in the production of thymic Tregs

第47回日本免疫学会学術集会

第47回日本免疫学会学術集会


胸腺髄質上皮細胞における Aire 発現レベルと組織特異的自己抗原 遺伝子発現との関連性に関する検討


Transgenic human AIRE expression in NOD acquired resistance to the diabetes due to the impaired presentation of self-antigens in the pancreas

第46回日本免疫学会学術集会

第46回日本免疫学会学術集会


ほぼすべての胸腺髄質上皮細胞が成熟過程でAireを発現する機能を備えている

ほぼすべての胸腺髄質上皮細胞が成熟過程でAireを発現する機能を備えている

第28回日本リウマチ学会中国・四国支部学術集会

第28回日本リウマチ学会中国・四国支部学術集会


Possible defect in the Treg production in mice overexpressing AIRE/Aire which exhibit muscle-specific autoimmunity

第45回日本免疫学会学術集会

第45回日本免疫学会学術集会


A novel Aire-dependent subset of medullary thymic epithelial cells that express Ly6 family protein

第44回日本免疫学会学術集会

第44回日本免疫学会学術集会


Paradoxical development of polymyositis-like autoimmunity by the additive expression of AIRE

第44回日本免疫学会学術集会

第44回日本免疫学会学術集会


Approaches to identify Aire-regulated non-tissue-restricted antigen genes by the ectopic expression of Aire in thymic cortex

第43回日本免疫学会学術集会

第43回日本免疫学会学術集会


Unexpected disturbance of the development of medullary thymic epithelial cells at immature stages by the long-term ablation of mature Aire-expressing cells

第43回日本免疫学会学術集会

第43回日本免疫学会学術集会


胸腺皮質上皮細胞への異所性発現による Aire の機能解析

胸腺皮質上皮細胞への異所性発現による Aire の機能解析


Requirement of Aire expression within thymic medulla but not cortex for establishing self-tolerance

第42回日本免疫学会総会

第42回日本免疫学会総会


Cell-cycle dependent phosphorylation of AIRE protein exogenously expressed in HeLa cells

AIRE遺伝子を導入したHeLa細胞における細胞周期依存的なAIREタンパク質のリン酸化

第35回日本分子生物学会年会

第35回日本分子生物学会年会


Differential requirement of Aire in two transgenic models for the negative selection of autoreactive thymocytes against self-antigens

2つのトランスジェニックモデルにおける負の選択機構におけるAire依存性の相違

第41回日本免疫学会学術集会

第41回日本免疫学会学術集会


Soluble insulin receptor ectodomain is elevated in the plasma of patients with diabetes.

International Symposium on Diabetes - Kickoff of Hannover-Tokushima Research Communiation


Nucling is important for the upregulation of Apaf-1/procaspase-9cytochrome c apoptosome following cellular stress in vivo

The 77th Annual Meeting of the Japanese Biochemical Society


Aire欠損mTECは異所性CTLA-4を発現することによって胸腺内DCの機能に影響を及ぼす．


胸腺髄質上皮細胞から樹状細胞への抗原転移におけるAireの役割

胸腺髄質上皮細胞から樹状細胞への抗原転移におけるAireの役割

日本胸腺研究会 2021年2月 on line 開催

日本胸腺研究会 2021年2月 on line 開催


ヒト AIRE トランスジェニックマウスに誘導される自己免疫性筋炎病態の解析

ヒト AIRE トランスジェニックマウスに誘導される自己免疫性筋炎病態の解析

第16回四国免疫フォーラム

第16回四国免疫フォーラム


ヒトAIRE トランスジェニックマウスに誘導される多発性筋炎病態の解析

ヒトAIRE トランスジェニックマウスに誘導される多発性筋炎病態の解析


NOD系統特異的に多発性筋炎様症状をもたらすゲノム領域の解析

NOD系統特異的に多発性筋炎様症状をもたらすゲノム領域の解析

第14回四国免疫フォーラム

第14回四国免疫フォーラム


AIRE遺伝子を導入したHeLa細胞における細胞周期依存的なAIREタンパク質のリン酸化

第54回日本生化学会 中国・四国支部例会

第54回日本生化学会 中国・四国支部例会


可溶性インスリン受容体細胞外ドメイン(sIRα)は高血糖に相関して血中濃度が高まる

第7回 1型糖尿病研究会

第7回 1型糖尿病研究会


The 1st Insulin Resistance in Metabolic Disease Forum