read0070771/misc/24315102 自動健診システムの開発とICカードの利用 CAMPUS HEALTH 42,2,21-25 null null 20050000 read0070771/misc/24315101 徳島大学生におけるHBs抗原およびHBs抗体陽性者の推移と肝機能異常 CAMPUS HEALTH 37,115-119 null null 20010000 read0070771/misc/24315100 Tanaka Haruko Maeda Kenichi Nakamura Yoichi CD40 and IFN-_γ dependent T cell activation by human bronchial epithelial cells CD40 and IFN-γ dependent T cell activation by human bronchial epithelial cells We examined whether freshly isolated human bronchial cells (HBEC) and bronchial epithelial cell line/ BEAS-2B cells expressed surface molecules required for APC function. These cells expressed CD40 and ICAM-1, but not B7-1, B7-2 or HLA-DR molecules. Treatment of these cells with IFN-γ resulted in enhanced expression of CD40 and ICAM-1 as well as induction of HLA-DR expression. Th2 cytokines such as IL-4 and IL-5, proinflammatory cytokine of GM-CSF and nonspecific activator endotoxin had no effect on these phenotypic expressions. Functional examinations showed that allogeneic lymphocytes purified from peripheral blood strongly proliferated in response to BEAS-2B cells cultured with IFN-γ, but only weakly compared with those without IFN-γ. When allogeneic lymphocytes were purified to CD4+ cells, the proliferative response against BEAS-2B cells was abolished. Blockade of CD40-CD40L interaction by anti-CD40 antibody also inhibited the proliferation of lymphocytes to BEAS-2B cells, although this treatment showed a minimum effect on the response to allogeneic MNC. Thus, bronchial epithelial cells have the ability to present allogeneic antigens to T cells in both CD40- and IFN-γ- dependent manners under the presence of third party cells that transduce co-stimulatory signals. The University of Tokushima 徳島大学 J. Med. Invest. The journal of medical investigation : JMI 1343-1420 48 1-2 109 117 20010000 read0070771/misc/24315099 Toshiya Takahashi Ken-Ichi Maeda Yoichi Nakamura Yoshio Okano Ning Ge Saburo Sone Interleukin-10 inhibits the production of inflammatory cytokines by antigen-stimulated mononuclear cells from asthmatic patients Blackwell Publishing Allergology International 1323-8930 49 1 55 62 20000000 10.1046/j.1440-1592.2000.00159.x 2-s2.0-0034076066 read0070771/misc/24315098 Antigen-specific B cells are required for the secondary response of T cells but not for their priming Eur. J. Immunol. 0014-2980 26 7 1628 1633 19960000 10.1002/eji.1830260733 8766571 read0070771/misc/24315096 A FURUKAWA KI MAEDA M MIYASAKA S KAGAWA K YASUTOMO H HISAEDA H NAGASAWA K HIMENO ESTABLISHMENT OF A XENOGENEIC CHIMERA WITHOUT GVHD IN NK CELL-DEPLETED SCID MICE BY GRAFTING RAT FETAL LIVER-CELLS CELLULAR IMMUNOLOGY 0008-8749 164 2 176 181 19950900 10.1006/cimm.1995.1159 7656325 read0070771/misc/24315097 _γδT cells play an important role in hsp65 expression and in acquiring protective immune responses against infection with Toxoplasma gondii J. Immunol. 154 244 251 19950000 read0070771/misc/24315095 K YASUTOMO KI MAEDA S NAGATA H NAGASAWA K OKADA RA GOOD Y KURODA K HIMENO DEFECTIVE T-CELLS FROM GLD MICE PLAY A PIVOTAL ROLE IN DEVELOPMENT OF THY-1.2(+)B220(+) CELLS AND AUTOIMMUNITY JOURNAL OF IMMUNOLOGY 0022-1767 153 12 5855 5864 19941200 read0070771/misc/24315091 K MAEDA H NAGASAWA A FURUKAWA H HISAEDA K HIMENO SPLIT TOLERANCE BETWEEN SPLEEN AND LYMPH-NODE CELLS IN SEVERE COMBINED IMMUNODEFICIENCY MICE GRAFTED WITH AKR FETAL LIVER-CELLS INTERNATIONAL IMMUNOLOGY 0953-8178 6 8 1213 1219 19940800 10.1093/intimm/6.8.1213 7981149 read0070771/misc/24315090 Development of T cells in SCID mice grafted with fetal thymus from AKR mice or F344 rats Eur. J. Immunol. 0014-2980 23 12 3151 3157 19930000 10.1002/eji.1830231217 8258329 read0070771/misc/24315094 Induction of heat shock protein closely correlates with protection against Toxoplasma gondii infection Proc. Natl. Acad. Sci. USA 0027-8424 89 7 3155 3158 19920000 10.1073/pnas.89.7.3155 1557424 read0070771/misc/24315089 KI MAEDA S SONE Y OHMOTO T OGURA A NOVEL DIFFERENTIATION ANTIGEN ON HUMAN MONOCYTES THAT IS SPECIFICALLY INDUCED BY GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR OR IL-3 JOURNAL OF IMMUNOLOGY 0022-1767 146 11 3779 3784 19910600 read0070771/misc/24315093 Selective elimination of double-positive immature thymocytes by a thymic epithelial cell line Eur. J. Immunol. 20 .47-53 null null 19900000 10.1002/eji.1830200108 read0070771/misc/24315092 K MAEDA M NAKASHIMA S KOMORI T WATANABE TRANS-ACTING REGULATORY FACTORS FOR T-CELL ANTIGEN RECEPTOR ALPHA-CHAIN AND GAMMA-CHAIN GENE-EXPRESSION JOURNAL OF IMMUNOLOGY 0022-1767 140 8 2796 2801 19880400