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en: One-pot Synthesis of alpha-Siloxyesters Using a Silylated Masked Acyl Cyanide

en: Synthesis

ja: Synthesis


en: Direct One-pot Synthesis of alpha-Siloxy-Weinreb Amides from Aldehydes

en: A one-pot method for synthesizing alpha-siloxy-Weinreb amides from aldehydes was developed with use of N,O-dimethylhydroxylamine and a masked acyl cyanide reagent bearing a tert-butyldimethylsilyl group avoiding the competitive reaction toward N-methoxy-N-methyl-2-amino-1-siloxymalononitrile.

en: The Journal of Organic Chemistry

ja: The Journal of Organic Chemistry


en: Highly diastereoselective nucleophilic addition reactions of masked acyl cyanide reagents to tert-butanesulfiminides

en: Tetrahedron: Asymmetry

ja: Tetrahedron: Asymmetry


en: Synthesis of alpha-Amino Acid Precursors Directly from Aldehydes using Masked Acyl Cyanide Reagents and N,O-Dialkylated Hydroxylamines

en: A synthetic methodology for the synthesis of alpha-amino acid precursors directly from the corresponding aldehydes using N,O-dialkylated hydroxylamines and masked acyl cyanide (MAC) reagents was developed. The one-pot reaction can be carried out under mild conditions and without a separate purification step of the imino species. The method was applied to the synthesis of optically pure (+)-4-methylphenylglycine and the derivatives by using an Abiko-Masamune's tricyclic 1,2-oxazolidine as the chiral auxiliary.


en: Synthesis of a water-soluble molecular tweezer and a recognition study in an aqueous media

en: Tetrahedron Letters

ja: Tetrahedron Letters


en: Synthesis and DNA damaging ability of enediyne model compounds possessing photo-triggering devices

en: Enediyne model compounds possessing photo-triggering devices were developed. These enediynes afforded biradicals by UV irradiation and showed DNA cleaving activity. The DNA damage was confirmed to be mainly caused by the biradical, not singlet oxygen.

en: Bioorganic & Medicinal Chemistry Letters


en: Synthesis and DNA damaging ability of enediyne polyamine conjugates


en: Developments of Enediyne Model Compounds Generating Biradicals with an Enhanced Radical Character Regulation of Triggering Devices

en: Heterocycles

ja: Heterocycles


en: Highly efficient chiral resolution and determination of absolute configuration of 2-alkanols by using a cyclopenta[b]furan derivative.

en: The reaction of 3a-benzhydryl-3,3a,4,5-tetrahydro-2H-cyclopenta[b]furan and various 2-alkanols in the presence of a catalytic amt. of pyridinium 4-toluenesulfonate in dichloromethane gave 3a-benzhydryl-6a-(1-methyl-alkoxy)-hexahydrocyclopenta[b]furan in more than 90% chem. yields. The resulting diastereomeric mixt. is easily separable on silica gel chromatog. because of the large Rf value (briefly 0.1). Abs. configuration of the 2-alkanols can be easily estd. by the chem. shifts of 1H and 13C NMR of methyne group of the benzhydryl moiety.


en: Synthesis, reactions and DNA damaging abilities of 10-membered enediyne-sulfone and related compounds

en: Tetrahedron

ja: Tetrahedron


en: A three-step preparation of MAC reagents from malononitrile

en: MAC反応剤の新しい合成法を開発した．従来の合成で7段階だったものが3段階に減り，総収率も著しく向上した．また従来の合成法では合成できなかった誘導体を新合成法で可能とした．


en: Synthesis of enediyne model compounds possessing a cyanohydrin moiety as a triggering device


en: Synthesis of Methyl 3-Amino-2-hydoroxy-4-phenylbutanoates,Important Core Intermediates for Peptide Mimics Possessing Biological Activities


en: Acid-catalyzed Cycloaromatization of Enediyne Model Compounds via Enyne-allene Intermediates.


en: Synthesis of Endiyne Model Compounds Producing Toluene Diradicals Possessing a Highly Radical Character via Enyne-allene Intermediates


en: A New One-Pot Method for the Synthesis of a-Siloxyamides from Aldehydes or ketones and Its Application to the Synthesis of (-)-Bestain

en: A new one-pot method for the synthesis of alpha-siloxyamides is described. The three substrates, H-C(CN)(2)O-SiMe(2)t-Bu, aldehydes or ketones, and primary or secondary amines, are simply mixed in one portion in acetonitrile or ether; the alpha-siloxyamides are obtained within short peroids in excellent yields in many cases. As a demonstration of our method, the synthesis of (-)-bestatin was carried out.

en: Organic Letters

ja: Organic Letters


en: Synthesis of optically active phenylglycine derivatives from Ss-(+)-N-(benzylidene)-p-toluenesulfinamide by using Lewis acids and tert-amines

en: Journal of Organometallic Chemistry

ja: Journal of Organometallic Chemistry


en: A conformationally Reliable Spacer for Molecular Tweezers

en: [figure: see text] A reliable and rigid spacer, trans,trans,trans-perhydronaphthacene, for molecular tweezers was designed. A synthesis and molecular recognition study of its 1,14-disubstituted derivatives was carried out.


en: Development of method for the preparation of a-azido-masked acyl cyanides,synthetic equivalents of N-protected C-activated a-amino acids


en: Decarboxylative cycloaromatization of enediyne model compounds --- Mechanism of the radical and ionic pathway

en: Tetrahedron Letters


en: Stereoselective synthesis of alkyenylated malonic diamide using masked acylcyanide


en: Design and synthesis of cholestane derivatives bearing a cascade-type polyol and the effect of their property on a complement system in rat serum

en: Bioorganic & Medicinal Chemistry Letters


en: Photocleavage of DNA bu the Halo Benzamide Derivatives of Oligo-N-Methylpyrrolecarboxamides

en: Heterocycles


en: Synthesis and Evalution of Enantiomerically Pure Azinomycin-Lexitropsin Hybrid Moleculeswith DNA-Cleaving Activity


en: pH dependent cycloaromatization of enediyne model compounds via γ-oxo ketene acetal intermediates


en: Synthesis and evaluation of the hybrid molecules possessing DNA-cleaving activity

ja: Bioorganic & Medicinal Chemistry Letters


en: Pyridoxal-mediated cycloaromatization of an enediyne model system


en: A new method for the preparation of phenyl-substituted cis-enediyne from a phthalide derivative

en: Chemical & Pharmaceutical Bulletin

ja: Chemical & Pharmaceutical Bulletin


en: Cycloaromatization of enediyne model compounds via a reaction cascade triggered by hydrolysis of the a-alkynylmalonates


en: pH dependent cycloaromatization of enediyne model compounds via enyne-allene intermediates


en: Development of molecules possessing DNA cleaving activity

en: Tennen Yuki Kagobutsu Toronkai Koen Yoshishu 38th