Highly Efficient, Enantiocontrolled Total Syntheses of (+)-Heliannuol D and (-)-Helibisabonol A


Concise total syntheses of heliannuols B and D


Enantioselective total syntheses of pygmaeocins B and C

The first enantioselective total syntheses of pygmaeocins B and C have been accomplished using an efficient and highly diastereoselective intramolecular Heck cyclization for the construction of a quaternary stereogenic center and the functionalized A-ring of the natural products as the key step.


Regio- and diastereoselective synthesis of functionalized hydroxyhexahydrocyclopenta[b]furancarboxylates by oxidative radical cyclization of cyclic β-keto esters with alkenes


Regiocontrolled construction of furo[3,2-c]pyran-4-one derivatives by palladium-catalyzed cyclization of propargylic carbonates with 4-hydroxy-2-pyrones

The reaction of propargylic carbonates with 4-hydroxy-2-pyrones in the presence of a palladium catalyst is described. By the choice of the reaction temperature, two types of the substituted furo[3,2-c]pyran-4-one derivatives were regioselectively synthesized, respectively.


Diastereoselective intramolecular carbamoylketene/alkene [2+2] cycloaddition: Enantioselective access to pyrrolidinoindoline alkaloids

A novel and highly diastereoselective intramolecular carbamoylketene/alkene [2 + 2] cycloaddition has been developed, and the methodology was successfully applied to the enantioselective syntheses of (-)-esermethole and Takayama's intermediate for (+)-psychotrimine.


Total syntheses of (±)-folicanthine and (±)-chimonanthine via a double intramolecular carbamoylketene-alkene [2+2] cycloaddition


An efficient access to aspermytin A and oblongolide C through an intramolecular nitrile oxide-alkene [3+2] cycloaddition


Synthesis of (±)-esermethole via an intramolecular carbamoylketene-alkene [2+2] cycloaddition.


Synthesis of Oxazolidinones by Efficient Fixation of Atmospheric CO2 with Propargylic Amines by using a Silver/1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) Dual-Catalyst System

This'll fix it: efficient fixation of atmospheric CO(2) has been achieved by the reaction of propargylic amines with a silver/DBU dual-catalyst system. Various oxazolidinones were synthesized in moderate to good yields by using substituted propargylic amines.


Total synthesis of debromoflustramines B and E based on the intramolecular carbamoylketene-alkene [2+2] cycloaddition

Total synthesis of debromoflustramines B and E has been accomplished by using a platinum-catalyzed addition reaction of o-aminophenylboronic acid with the allene and an intramolecular carbamoylketene-alkene [2 + 2] cycloaddition for the construction of the basic carbon framework of the target alkaloids as the key steps.


Regio- and enantioselective synthesis of functionalized tetrahydroquinolines by palladium-catalyzed cyclization of 2-amidophenylmalonates with allylic bisacetates


Total synthesis of natural enantiomers of heliespirones A and C via the diastereoselective intramolecular Hosomi-Sakurai reaction

A full account of the development of a novel type of the intramolecular Hosomi-Sakurai reactions of the substrates with a p-benzoquinone and an allylsilane moieties connected by an ether linkage is described. This transformation proceeds via an addition-elimination sequence and provides the products with two stereogenic centers through a 1,3(or 1,4)-asymmetric induction in good to excellent diastereoselectivities. A reasonable mechanistic possibility for the reaction, determination of the stereochemistry for the product, and scope and limitation of the transformation are also discussed. The methodology developed here can successfully be applied to the enantiocontrolled total synthesis of the natural enantiomers of (-)-heliespirone A and (+)-heliespirone C, which have been isolated from sunflower Helianthus annuus L. as allelochemicals.


Enantioselective synthesis of 8-epi-xanthatin and biological evaluation of xanthanolides and their derivatives.

An enantioselective synthesis of 8-epi-xanthatin (9) has been accomplished starting from the bicyclic lactone 3, which has been used for the synthesis of other xanthanolides, sundiversifolide (4) and diversifolide (5), through a synthetic route without the use of a selenium species. Additionally we have evaluated antimicrobial activities of five natural xanthanolides and their derivatives. Although the synthetic xanthanolides did not show any activity against methicillin-resistant Staphylococcus aureus (MRSA), some of the synthetic intermediates did exhibit moderate antimicrobial activities.


Total synthesis of (±)-3-hydroxy-β-ionone through a ring-closing enyne metathesis


Synthesis of tetrasubstituted furans by palladium-catalyzed decarboxylative [3+2] cyclization of propargyl beta-keto esters


Enantioselective total synthesis of heliespirone B


The first total synthesis of penostatin B has been accomplished by using a highly diastereoselective Pauson-Khand reaction and an efficient relay ring-closing metathesis for the construction of the basic carbon skeleton of the natural product as the key steps.


Enantiocontrolled access to the ionone type bisnorsesquiterpenes. Total syntheses of 3-oxo-α-ionol and related natural products


S-15176 and its methylated derivative suppress the CsA-insensitive mitochondrial permeability transition and subsequent cytochrome c release induced by silver ion, and show weak protonophoric activity.

A recent report has described that S-15176 (N-[(3,5-di-tert-butyl-4-hydroxy-1-thiophenyl)]-3-propyl-N'-(2,3,4-trimethoxybenzyl) piperazine), an anti-ischemic agent, inhibits the mitochondrial permeability transition (PT) induced by not only Ca(2+) and inorganic phosphate, but also by tert-butylhydroperoxide or phenylarsine oxide [Morin et al. (Biochem Pharmacol 72:911-918, 2006)]. In the present study, we tested the effects of S-15176 on the PT induced by Ag(+), PT of which is not suppressed by cyclosporin A or oligomycin. S-15176 was effective in suppressing the PT and the subsequent cytochrome c release induced by Ag(+), and hence, it was concluded to be a more universal PT inhibitor than cyclosporin A or oligomycin. In addition to the PT-suppression activity, S-15176 also showed weak protonophoric activity. Thus, we further tested to investigate whether the hydroxyl group of S-15176 was involved in its PT-suppression or weak protonophoric activities. The methylated derivative of S-15176 also showed both PT suppression and weak protonophoric activities; hence, the hydroxyl group of S-15176 was concluded not to be involved in these activities.


Synthesis of substituted 1,4,5,6-tetrahydrocyclopenta[b]pyrroles by platinum-catalyzed cascade cyclization/ring expansion of 2-alkynyl-1-azaspiro[2.3]hexanes

The reaction of 2-alkynyl-1-azaspiro[2.3]hexanes with a platinum catalyst is described. 1,4,5,6-Tetrahydrocyclopenta[b]pyrroles having a variety of substituents were conveniently synthesized via a cascade cyclization/ring-expansion process.


Diastereoselective construction of 7-methylenebicyclo[3.2.1]oct-3-en-2-one derivatives by palladium-catalyzed cyclization of propargylic acetates with 2-oxocyclohex-3-enecarboxylates

The reaction of propargylic acetates with 2-oxocyclohex-3-enecarboxylates in the presence of a palladium catalyst is described. Substituted 7-methylenebicyclo[3.2.1]oct-3-en-2-ones were synthesized in a highly diastereoselective manner.


Efficient access to a dihydropyran-containing macrolide via a transannular oxy-Michael reaction: total synthesis of (+)-aspergillide C

The second-generation enantioselective total synthesis of aspergillide C, a new type of 14-membered macrolide isolated from a marine-derived fungus, has been accomplished in a longest linear sequence of 15 steps from a chiral building block in 19% overall yield employing the 6-exo-trig transannular oxy-Michael reaction as the key step.


Enantioselective syntheses of the assigned structures of the helibisabonols A and B


Enantiocontrolled total syntheses of breviones A, B, and C

Enantiocontrolled total syntheses of the breviones A, B, and C have been accomplished using a highly diastereoselective oxidative coupling of an α-pyrone with a tricyclic diene prepared from an optically pure Wieland-Miescher ketone derivative through the 7-endo-trig mode of acyl radical cyclization.

Journal of the American Chemical Society


Efficient and enantioselective total syntheses of heliannuols A and K


Efficient Enantioselective Total Synthesis of (+)-Helianane


Synthesis of substituted 3-iodopyrroles by cycloisomerization of propargylic aziridines with iodine


Total synthesis of the aspergillides A and B based on the transannular oxy-Michael reaction


Antioxidant effects of photodegradation product of nifedipine

Recently, increasing evidence suggests that the antihypertensive drug nifedipine acts as a protective agent for endothelial cells, and that the activity is unrelated to its calcium channel blocking. Nifedipine is unstable under light and reportedly decomposes to a stable nitrosonifedipine (NO-NIF). NO-NIF has no antihypertensive effect, and it has been recognized as a contaminant of nifedipine. The present study for the first time demonstrated that NO-NIF changed to a NO-NIF radical in a time-dependent manner when it interacted with human umbilical vein endothelial cells (HUVECs). The electron paramagnetic resonance (EPR) signal of NO-NIF radicals in HUVECs showed an asymmetric pattern suggesting that the radicals were located in the membrane. The NO-NIF radicals had radical scavenging activity for 1,1-diphenyl-2-picrylhydrazyl, whereas neither NO-NIF nor nifedipine did. In addition, the NO-NIF radical more effectively quenched lipid peroxides than NO-NIF or nifedipine. Furthermore, NO-NIF attenuated the superoxide-derived free radicals in HUVECs stimulated with LY83583, and suppressed iron-nitrilotriacetic acid (Fe-NTA)-induced cytotoxicity in rat pheochromocytoma (PC12) cells. Our findings suggest that NO-NIF is a candidate for a new class of antioxidative drugs that protect cells against oxidative stress.


Concise and efficient synthesis of 4-hydroxy-2-pyrones from pentane-2,4-diones.


Stereoselective synthesis of cyclic hemiacetals from 4-formylbenzoates and α,β-unsaturated aldehydes using a sulfoalkyl-substituted N-heterocyclic carbene catalyst


Highly regioselective synthesis of substituted tetrahydroquinolines by palladium-catalyzed cyclization of substituted 2-amidophenylmalonates with 1,4-diacetoxybut-2-ene


An efficient total synthesis of (+)-heliannuol D


Enantioselective formal total synthesis of aplysin utilizing a palladium-catalyzed addition of an arylboronic acid to an allenic alcohol Eschenmoser-Claisen rearrangement


Highly diastereoselective synthesis of tetrahydrobenzofuran derivatives by palladium-catalyzed reaction of propargylic esters with substituted beta-dicarbonyl compounds


Synthesis of (±)-heliannuol D based on platinum catalyzed regioselective addition of arylboronic acids to allene.


A synthetic study of bauhinoxepin J: Construction of a dibenzo[b,f]oxepin ring system by a DDQ-promoted oxidative dearomatization cyclization approach.


Stereoselective construction of substituted chromans by palladium-catalyzed cyclization of propargylic carbonates with 2-(2-hydroxyphenyl)acetates

Highly substituted chromans have been constructed in a highly stereoselective manner by a palladium-catalyzed reaction of propargylic carbonates with 2-(2-hydroxyphenyl)acetates. Enantioselective reactions also successfully proceeded to give the optically active chromans with high enantioselectivity.


Synthesis of substituted 3-iodopyrroles by electrophilic cyclization of propargylic aziridines


Oxidative carboxylation of arylaldehydes with water by a sulfoxylalkyl-substituted N-heterocyclic carbene catalyst

The N-Heterocyclic carbene-catalysed oxidative carboxylation of arylaldehydes with water successfully proceeded when a sulfoxylalkyl-substituted imidazolium salt was used as the catalyst. The reactions can be run in the absence of oxidant, and a variety of arylaldehydes having an electron-withdrawing group were converted to the corresponding carboxylic acids.


Total synthesis of bongkrekic acid via sequential Suzuki Miyaura coupling reactions.


Syntheses of substituted furans and pyrroles by platinum-catalyzed cyclizations of propargylic oxiranes and aziridines in aqueous media.


Total Synthesis of Radulanin H and Proposed Structure of Radulanin E.


Synthesis of (-)-Heliannuol E via Mercuric Triflate Catalyzed Arylene Cyclization


Total syntheses of enokipodins A and B utilizing palladium-catalyzed addition of an arylboronic acid to an allene

The enantioselective total syntheses of enokipodins A and B, alpha-cuparenone-type sesquiterpenoids with antimicrobial activity, have been achieved. The key step is the enantiospecific construction of the quaternary carbon center using a palladium-catalyzed addition of an arylboronic acid to an allene followed by an Eschenmoser-Claisen rearrangement.


Diastereoselective construction of substituted tetrahydropyrans using an intramolecular oxy-Michael strategy


Diastereoselective construction of chiral building blocks for the synthesis of indole alkaloids using an intramolecular Heck reaction


Synthesis of sundiversifolide and diversifolide via a diastereoselective [3+2] nitrile oxide cycloaddition reaction


Rhodium-catalyzed diastereoselective coupling of propargylic oxiranes with arylboronic acids in water


Regiocontrolled addition of arylboronic acids to allenes using palladium and platinum catalysts.

Studies about the regiocontrolled addition of arylboronic acids to allenes using a palladium or a platinum catalyst have been described. The selectivity of the reaction can be altered by the choice of the metal reagent and base. Contrary to the formation of endo-olefinic products in the reactions using hydroxopalladium complex, predominant production of exo-olefinic products was observed by the reaction with hydroxoplatinum complex.


Synthesis of substituted furans by platinum-catalyzed cyclization of propargylic oxiranes in aqueous media


Synthesis of diversifolide and structure revision


A Stereoselective Route Towards Heliannuol A


Total synthesis of (+)- and (-)-sundiversifolide via intramolecular acylation and determination of the absolute configuration

Intramolecular acylation of an organolithium leads to an efficient stereocontrolled total synthesis of both enantiomers of sundiversifolide. The absolute configuration was determined by HPLC analysis and allelopathy assay. The gamma-lactone moiety resulted from a butenolide was obtained by the condensation of a bicyclic alpha-hydroxyhemiacetal with Ph3P=CMe(CO2R).


Highly diastereoselective synthesis of tetrahydrobenzofuranones by palladium-catalyzed reaction of propargylic carbonates with 2-substituted cyclohexane-1,3-diones


Total syntheses of phomallenic acids B and C utilizing palladium-catalyzed coupling of propargylic tosylates with terminal alkynes


Hyperconjugative Effect of C-Ge Bonds: Synthesis of Multisubstituted Alkenylgermanes via Torquoselective Olefination of Acylgermanes with Ynolates


Synthesis of Multisubstituted Furans, Pyrroles and Thiophenes via Ynolates

An efficient synthetic method for the preparation of multisubstituted furans, thiophenes, and pyrroles using ynolates was developed. This novel formal [4 + 1] annulation by C2-C3 and C3-C4 bond formations includes cycloaddition, cyclization, decarboxylation, and dehydration as key steps.


Palladium-Catalyzed Diastereoselective Coupling of Propargylic Oxiranes with Terminal Alkynes.

[reaction: see text] A diastereoselective coupling of propargylic oxiranes with terminal alkynes has been developed with use of a palladium catalyst. The stereochemistries of the resulting 4-alkynyl-substituted 2,3-allenols have been altered depending on the palladium catalyst. An optically active anti-substituted allene was synthesized from the reaction of an enantiomerically enriched propargylic oxirane without loss of chirality.


Total synthesis of (+)-sundiversifolide.

The first, enantiocontrolled total synthesis of (+)-sundiversifolide has been accomplished using the sequential ring-closing metathesis, [3,3]-sigmatropic rearrangement, and iodolactonization for the key assembly of the cis-fused oxabicyclo[5.3.0]decene framework of the natural product. [structure: see text]


Acid-Catalyzed Nazarov Reaction Controlled by β-Alkoxy Groups


Generation of Ynolate and Z-Selective Olefination of Acylsilanes:(Z)-2-Methyl-3-Trimethylsilyl-2-butenoic acid


Enantiospecific Synthesis of 1,3-Disubstituted Allenes by Palladium-Catalyzed Coupling of Propargylic Compounds with Arylboronic Acids.


Syntheses of heliannuols G and H; Structure revision of the natural products.


Asymmetric hydrogenation of the C-C double bond of 1- and 1,2-methylated maleimides with cultured suspension cells of Marchantia poliymorpha


[structure: see text]. An enantiocontrolled total synthesis of (+)-lasonolide A has been accomplished by using the sequential cross metathesis and macrolactonization for the key assembly of the 20-membered polyene macrolide core of the natural product.


Synthesis of Tetrasubstituted and Functionalized Enol Ethers by E-Selective Olefination of Esters with Ynolates

We have developed the E-selective olefination of ester carbonyls to afford tetrasubstituted, functionalized olefins and the C-S insertion of thiol esters to give beta-keto thiol esters via ynolates.

Journal of the American Chemical Society


Heteroatom-Guided Torquoselective Olefination of α-Oxy and α-Amino Ketones via Ynolates

Ynolates were found to react with alpha-alkoxy-, alpha-siloxy-, and alpha-aryloxyketones at room temperature to afford tetrasubstituted olefins with high Z selectivity. Since the geometrical selectivity was determined in the ring opening of the beta-lactone enolate intermediates, the torquoselectivity was controlled by the ethereal oxygen atoms. From experimental and theoretical studies, the high Z selectivity is induced by orbital and steric interactions rather than by chelation. In a similar manner, alpha-dialkylamino ketones provided olefins with excellent Z selectivity. These products can be easily converted into multisubstituted butenolides and gamma-butyrolactams in good yield.


Enantioselective Synthesis of Heliannuols G and H


Asymmetric Inverse Electron-demand 1, 3-Dipolar Cycloaddition of Ynolates with a Chiral Nitrone Derived from L-Serine Leading to β-Amino acid Derivatives


[2+2] and [2+4] Type Cycloadditions of Isocyanates with Ynolates


A synthesis of multisubstituted vinylsilanes via ynolates:stereoselective formation of β-silyl-β-lactones followed by decarboxylation

(Z)-Selective synthesis of multisubstituted vinylsilanes was achieved by stereoselective protonation or alkylation of beta-silyl-beta-lactone enolates, prepared by cycloadditions of acylsilanes with ynolates, followed by decarboxylation.


Intramolecularly Activated Vinylsilanes:Fluoride-free Cross-Coupling of (Z)-β-( Trialkylsilyl ) acrylic Acids


Enantiocontrolled Synthesis of a Chiral Building Block via Diastereoselective Ring-closing Metathesis


Diastereoselective Synthesis of the 19-epi-C18-C25 Segment of (+)-Lasonolide A and an Unusual Inversion at C19


Electronic effect on the regioselectivity in the ring opening of para-substituted phenyloxiranes by acetylides


Stereoselective Olefination of Unfunctionalized Ketones via Ynolates


Electrophilic Cleavage of One Silicone-Carbon Bond of Pentacoordinate Tetraorganosilanes. Novel Synthesis of Silalactones


A formal total synthesis of (-)-limaspermine


First Enantioselective Total Synthesis of (-)- Heliannuol C


Diastereoselective 1,3-Dipolar Cycloaddition of Ynolates with Chiral Nitrones


Enantiocontrolled total synthesis of (+)-heliannuol D via palladium-mediated heterocyclization


Synthesis of α,α-Dibromo Esters as Precursors of Ynolates

Aliphatic α,α-dibromo esters, precursors of ynolates, were synthesized via bromination of lithium α-bromo ester enolates with 1,2-dibromotetrafluoroethane in good yields. α-Trimethylsilyl-α,α-dibromo esters were synthesized via radical bromination.


Total synthesis of (-)- Aspidospermine via Diastereoselective Ring-Closing Metathesis

An enantiocontrolled total synthesis of (-)-aspidospermine has been achieved. The key element of the strategy is the diastereoselective construction of the quaternary stereogenic center employing 1,4-asymmetric induction during the ring-closing olefin metathesis.


Enantioselective total synthesis of (-)-heliannuol A

An efficient and enantiocontrolled total synthesis of (-)-heliannuol A has been accomplished by employing ring closing metathesis and sequential diastereoselective epoxidation and regioselective reductive cleavage of the epoxide ring.


Enantiocontrolled synthesis of (+)-curcuquinone and (-)-curcuhydroquinone


Enantioselective Construction of the C1-C16 Segment of Lasonolide A


An Alternative Total Synthesis of (-)- Heliannuol E


Anionic Inverse Electron-Demand 1,3-DipolarCycloaddition of Nitrones with Ynolates. Facile Stereoselective Synthesis of 5-Isoxazolidinones Leading to β-Amino Acids

[reaction: see text] The inverse electron-demand 1,3-dipolar cycloaddition of nitrones with ynolates, followed by quenching with t-BuOH, produced substituted 5-isoxazolidinones with good trans-selectivity. These products were easily converted into beta-amino acids.


Apoptosis-inducing activity of synthetic intermediates of halichlorine.

Synthetic intermediates of alkaloid halichlorine with the azaspiro core structure have been found to induce apoptosis of cultured human cells including an acute monocytic leukemia cell line (THP-1) at micromolar concentrations. The novel biological activity of the intermediates was suggested to depend on the skeletal structure and silyloxymethyl functionality on the five-membered ring.

Bioorganic & Medicinal Chemistry Letters


An ynolate-initiated tandem process giving cyclopentenones:total synthesis of cucumin E


The First General Method for Z-Selective Olefination of Silyl Ketones via Ynolate Anions Providing Multisubstituted Alkenes

We have developed the first general method for a stereoselective olefination of acylsilanes via ynolate anions to produce (Z)-beta-silyl-alpha,beta-unsaturated ester, which leads to tri- and tetrasubstituted alkenes.

Journal of the American Chemical Society


Diastereoselective Ring Closing Metathesis for the Construction of a Quaternary Carbon Stereogenic Center


Enantioselective Synthesis of Biologically Active Natural Products with Quaternary Stereogenic Center

My Favorite Organic Synthesis-The 60th Anniversary of the Society of Organic Chemistry


Fragmentation Reactions of Optically Active Trissubstituted Cyclopropylcarbinyl Radicals

Fragmentation reactions of optically active trisubstituted cyclopropylcarbinyl radicals and their application to the synthesis of natural products are described. Preparation of the optically pure substrates for radical fragmentation reactions was efficiently accomplished by lipase-mediated desymmetrization of sigma-symmetrical 3-substituted-1,2-cyclopropanedimethanols. In the presence of a radical stabilizing group, e.g., aryl, ester, or alpha,beta-unsaturated ester, the fragmentation occurs selectively to generate the radical on the alpha-carbon of the group and provide the optically pure alkene derivatives. These derivatives possess three chemically distinct functionalities, making them excellent chiral building blocks for the construction of biologically active molecules. The synthetic usefulness of the procedure developed here has been demonstrated by an application to the enantioselective synthesis of both enantiomers of the key intermediate, 4-(3,4-methylenedioxybenzyl)dihydrofuran-2(3H)-one (54), for the total synthesis of biologically active lignans.


Practical synthesis of ynolate anions: naphthalene-catalyzed reductive lithiation of α,α-dibromo esters


A Novel tandem [2+2] Cycloaddition-Dieckmann Condensation with Ynolate Anions. Efficient Synthesis of Substituted Cycloalkenones and Naphthalenes via Formal [n+1] Cycloaddition

A novel tandem [2 + 2] cycloaddition-Dieckmann condensation via ynolate anions is described. Ynolate anions are useful for the formation of reactive beta-lactone enolates via a pathway not involving the enolization of the corresponding beta-lactones. The [2 + 2] cycloaddition of ynolate anions with delta- or gamma-keto esters, followed by Dieckmann condensation, gives bicyclic beta-lactones, which are easily decarboxylated to produce synthetically useful 2,3-disubstituted cyclopentenones and cyclohexenones in one pot. This tandem reaction was applied to a novel, one-pot synthesis of highly substituted naphthalenes.


The First Tandem [2+2] Cycloaddition-Michael Reaction Using Ynolates: Facile Construction of Substituted Carbocycles


Enantioselective Total synthesis of (-) -Equisetin Using Me3Al-Mediated Intramolecular Diels-Alder Reaction


Synthesis Studies on Halichlorine and Pinnaic Acid: Palladium-Mediated Construction of the Bicyclic Spiro Core


New Method for Activation of Aldimines in Cycloaddition of Lithium Ynolates with N-2-methoxyphenyl Imines Leading to β-Lactams


Highly E-selective systhesis of α,β-unsaturated amides from N-2-methoxyphenyl aldimines via lithium ynolates


The Efficient Entry Into the Tricyclic Core of Halichlorine


Lanthanoid Triflates Catalyzed Reaction of a Silyl Ynolate with Aldimines


Enantioselective total synthesis of Heliannuol D and A

Journal of the Chemical Society, Perkin Transactions 1


Stereoelectronic Effect on Stereoselective Olefination of Ketones Prooviding Tetrasubstituted Olefins via Ynolates


Selective Cleavage of the Trisubstituted Cyclopropanes via Cyclopropylcarbinyl Radical Fragmentation


A Novel tandem [2+2] Cycloaddition-Dieckmann Condensation : Facile One-pot Process to 2,3-disubstituted-2-cycloalkenones from Ynolates

Journal of the American Chemical Society


An Enantiocontrolled Total Synthesis of (-) -Xanthorrhizol


Terpenoids in Transformed Root Culture of Tripterygium Wilfordii


Lipase-mediated Asymmetric Acetylation of Prochiral Diols Directed Towards Total Syntheses of Biologically Actiive Molecules

Journal of Molecular Catalysis B: Enzymatic


Novel and General Entry into Pseudoguaianolides. Formal and Enantioselective Synthesis of (+)-Confertin


Synthesis and Evalution of Enantiomerically Pure Azinomycin-Lexitropsin Hybrid Moleculeswith DNA-Cleaving Activity


Cycloaddition of Lithium Ynolate to Imines:Synthesis of 3,4-Disubstituted β-Lactams


A Highly Stereoselective Synthesis of Tri- and Tetrasubstituted Olefins via Ynolates


Novel Synthesis of Ynolates via the Cleavageof Ester Dianions:α-Bromo and α,α-Dibromo Esters as Precursors


Enantiocontrolled Synthesis of the Functionalized cis-Decalin


A General Asymmetric Access to the Podocarpane Diterpenoids


Enantioselective total synthesis and Structure Determination of the Mercapturic Acid sulfoxide Conjugate

Bioorganic & Medicinal Chemistry Letters


Lipase-mediated asymmetric construction of 2-arylpropionic acids:Enantiocontrolled syntheses of S-naproxen and S -ibuprofen


Enantiocontrolled total Synthesis of the Diiterpenoids, Triptoquinone B, C and Triptocallol


Enantioselective Access to the Mycotoxin, Aflatoxin B2


New Asymmetric Construction of the Benzylic Quaternary Stereogenic Centre: An Enantiocontrolled Access to (-)-α-Cuparenone


Chemoenzymatic Formal Synthesis of Indolmycin


Synthesis and evaluation of the hybrid molecules possessing DNA-cleaving activity


Structure Elucidation and Synthesis of a Metabolite of Antiinflammatory Drug DUP 697


A highly Convergent Enantioselective Total Synthesis of Marine Natural Product, Furanoterpene

Journal of the Chemical Society. Chemical Communications


Diastereoselective Oxidation of Mercapturates to Mercapturate Sulfoxides


An enantioselective total synthesis of (+)-cassiol