read0170980/misc/12964424 Encapsulation of an antivasospastic drug, fasudil, into loposomes, and in vitro stability of the fasdil-loaded liposomes Int. J. Pharm 232(2002),59-67 null null 20020000 10.1016/S0378-5173(01)00896-1 read0170980/misc/12964423 Effect of Cationic Liposomes in an in Vitro Transcription and Translation System Biol. Pharm. Bull 25(4),529-531 null null 20020000 10.1248/bpb.25.529 read0170980/misc/12964422 Quantitative Analysis of Correlation between Number of Nuclear Plasmids and Gene Expression Activity after Transfection with Cationic Liposomes Pharmaceutical Research 19(4),377-381 null null 20020000 10.1023/A:1015162722295 read0170980/misc/12964421 HEPC-based loposomes trigger cytokine release from periferal blood cells : Effects of loposomal size, does and lipid composition International Journal of Pharmaceutics 236(2002),125-133 null null 20020000 10.1016/S0378-5173(02)00026-1 read0170980/misc/12964420 Masahito Komuro Yasuro Kawaguchi Kazuho Okudaira Masahiro Hayashi Hiroshi Kiwada Ryotaro Azuma Comparative Analysis of In Vitro and In Vivo Pharmacokinetic Parameters Related to Individual Variability of GTS-21 in Canine Drug Metabolism and Pharmacokinetics 1880-0920 17 1 75 82 20020000 10.2133/dmpk.17.75 2-s2.0-0842344073 read0170980/misc/12964433 The complement system enhances the clearance of phosphatidylserine (PS)-liposomes in rat and guinea pig International Journal of Pharmaceutics 215,197-205 null null 20010000 10.1016/S0378-5173(00)00691-8 read0170980/misc/12964432 Soecies Difference in Correlation between in Vivo/in Vitro Lioposome-Complement Interactions Biol. Phar. Bull. 24(4),439-441 null null 20010000 10.1248/bpb.24.439 read0170980/misc/12964431 Efficacy of Intrathecal Liposomal Fasudil for Experinental Cerebral Vasospasm afte Subarachnoid Hemorrhage Neurosugery 48(4),894-901 null null 20010000 read0170980/misc/12964430 Intracellular control of gene trafficking using liposomes as drug carriers Eur. J. Pharm. Sci. 13(1),85-89 null null 20010000 10.1016/S0928-0987(00)00211-6 read0170980/misc/12964429 Effect of cholesterol content in activation of the classical versus the alternative pathway of rat complement system induced by hydrogenated egg phosphatidycholine-based liposomes Int. J. Pharm 224,69-79 null null 20010000 10.1016/S0378-5173(01)00737-2 read0170980/misc/12964428 Intracellular control of macromolecules by use of liposomes as drug carriers J. Biol. Macromol. 1(3),60-67 null null 20010000 read0170980/misc/12964427 First-pass of GTS-21 on cacine gut wall and liver determined by portal-systemic concentration difference Euro. J. Pharm. Sci. 14(2001),159-165 null null 20010000 10.1016/S0928-0987(01)00166-X read0170980/misc/12964426 Interactions of Liposomes with Cells In Vitro and In Vivo: Opsonins and Receptors Current Drug Metabolism 2001(2),397-409 null null 20010000 10.2174/1389200013338306 read0170980/misc/12964425 Quantitative studies on the nuclear transport of plasmid DNA and gene expression employing nonviarl vectors Advanced Drug Delivery Reviews 52(2001),219-226 null null 20010000 10.1016/S0169-409X(01)00211-3 read0170980/misc/12964436 有効性の向上とバイオアベイラビリティー 総合製剤学，杉山雄一，山本恵司編 431-443 null null 20000000 read0170980/misc/12964435 Biodistribution of liposomes and C3 fragments associated with liposomes: evaluation of their reltionship Int. J. Pharm 205,183-198,183-193 null null 20000000 10.1016/S0378-5173(00)00511-1 read0170980/misc/12964434 血中滞留性リポソームによる抗癌剤の処方設計における最適化 Drug Delivery System 15(5),467-442 null null 20000000 read0170980/misc/12964418 有効性の向上とバイオアベイラビリティー 総合製剤学,南山堂 431 443 20000000 read0170980/misc/12964384 A Nagayasu K Uchiyama H Kiwada The size of liposomes: a factor which affects their targeting efficiency to tumors and therapeutic activity of liposomal antitumor drugs ADVANCED DRUG DELIVERY REVIEWS 0169-409X 40 1-2 75 87 19991100 10.1016/S0169-409X(99)00041-1 10837781 read0170980/misc/12964383 H Harashima M Tsuchihashi S Iida H Doi H Kiwada Pharmacokinetic/pharmacodynamic modeling of antitumor agents encapsulated into liposomes ADVANCED DRUG DELIVERY REVIEWS 0169-409X 40 1-2 39 61 19991100 10.1016/S0169-409X(99)00039-3 10837779 read0170980/misc/12964382 H Harashima H Kiwada The pharmacokinetics of liposomes in tumor targeting ADVANCED DRUG DELIVERY REVIEWS 0169-409X 40 1-2 1 2 19991100 10.1016/S0169-409X(99)00036-8 read0170980/misc/12964386 H Harashima S Iida Y Urakami M Tsuchihashi H Kiwada Optimization of anti-tumor effect of liposomally encapsulated doxorubicin based on simulations by pharmacokinetic/pharmacodynamic modeling JOURNAL OF CONTROLLED RELEASE 0168-3659 61 1-2 93 106 19990800 10.1016/S0168-3659(99)00110-8 10469906 read0170980/misc/12964385 M Tsuchihashi H Harashima H Kiwada Development of a pharmacokinetic/pharmacodynamic (PK/PD)-simulation system for doxorubicin in long circulating liposomes in mice using peritoneal P388 JOURNAL OF CONTROLLED RELEASE 0168-3659 61 1-2 9 19 19990800 10.1016/S0168-3659(99)00103-0 10469899 read0170980/misc/12964380 M Kuwajima H Harashima M Hayashi S Ise M Sei KM Lu H Kiwada Y Sugiyama K Shima Pharmacokinetic analysis of the cardioprotective effect of 3-(2,2,2-trimethylhydrazinium) propionate in mice: Inhibition of carnitine transport in kidney JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 0022-3565 289 1 93 102 19990400 read0170980/misc/12964419 血中滞留性リポソーム封入ドキソルビシンの腹腔癌における抗腫瘍効果制御システムの構築 14 2 109 113 19990000 10.2745/dds.14.109 read0170980/misc/12964417 原島 秀吉 篠原 康雄 際田 弘志 キャリアによる細胞内デリバリー戦略と今後の課題 Drug Delivery System 0913-5006 14 3 157 164 19990000 10.2745/dds.14.157 read0170980/misc/12964416 ISHIDA Tatsuhiro 石田 竜弘 KIWADA Hiroshi 際田 弘志 Liposomes リポソーム Japan Society of Colour Material 一般社団法人 色材協会 Journal of the Japan Society of Colour Material 色材 0010-180X 72 3 184 191 19990000 10.4011/shikizai1937.72.184 read0170980/misc/12964381 In Vivo studies on the Role of Complement in the Clearance of Liposomes in RAts and guinea Pigs Biol. Pharm. Bull. 0918-6158 22 5 515 520 19990000 10.1248/bpb.22.515 10375174 read0170980/misc/12964379 H Nemoto J Kikuishi S Yanagida T Kawano M Yamada H Harashima H Kiwada M Shibuya Design and synthesis of cholestane derivatives bearing a cascade-type polyol and the effect of their property on a complement system in rat serum BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 0960-894X 9 2 205 208 19990100 10.1016/S0960-894X(98)00723-9 10021929 read0170980/misc/12964377 H Harashima H Matsuo H Kiwada Identification of proteins mediating clearance of liposomes using a liver perfusion system ADVANCED DRUG DELIVERY REVIEWS 0169-409X 32 1-2 61 79 19980600 10.1016/S0169-409X(97)00132-4 10837636 read0170980/misc/12964415 小島 弘子 石田 竜弘 原島 秀吉 際田 弘志 リポソーム膜中のコレステロール含量が及ぼす補体第3成分(C3)の結合と体内動態への影響 Drug Delivery System 0913-5006 13 1 55 61 19980000 10.2745/dds.13.55 read0170980/misc/12964378 Intracellular Regulation of Macromolecules Using pH-Sensitive Liposomes and Nuclear Localization Signal : Quqlitative and Quantitative Evaluation of Intracellular Trafficking Biochem. Biophys. Res. Commun. 0006-291X 251 2 538 544 19980000 10.1006/bbrc.1998.9460 9792809 read0170980/misc/12964376 Complement Dependent and Independent Liposome Uptake by Peritoneal Macrophages : Cholesterol Content Dependency Biol. Pharm. Bull 0918-6158 21 9 969 973 19980000 10.1248/bpb.21.969 9781849 read0170980/misc/12964375 Mizuki YAMADA Hideyoshi HARASHIMA Hiroshi KIWADA Kinetic Analysis of the Interaction between Liposomes and the Complement System in Rat Serum : Re-evaluation of Size-Dependency Biol. Pharm. Bull 0918-6158 21 9 964 968 19980000 10.1248/bpb.21.964 9781848 read0170980/misc/12964374 Mechanism of initial distribution of blood-borne colon carcinoma cells in the liver J. Hepatology 0168-8278 28 5 878 885 19980000 10.1016/S0168-8278(98)80239-0 9625324 read0170980/misc/12964373 A novel plasma factor initiating complement activation on cetylmannoside-modified liposomes in human plasma Int. Pharm. 0378-5173 164 1/2 91 102 19980000 10.1016/S0378-5173(97)00403-1 read0170980/misc/12964372 Characterization of Bovine Serum Factor Triggering the Lysis of Liposomes via Complement Activation Biol. Pharm. Bull 0918-6158 21 4 390 397 19980000 10.1248/bpb.21.390 9586579 read0170980/misc/12964369 Hiroshi Kiwada Plasma factors affecting disposition of liposomes Elsevier Science B.V. Advanced Drug Delivery Reviews 0169-409X 24 2-3 193 199 19970317 10.1016/S0169-409X(96)00458-9 2-s2.0-0343923463 read0170980/misc/12964368 H Kiwada Plasma factors affecting disposition of liposomes ADVANCED DRUG DELIVERY REVIEWS 0169-409X 24 2-3 193 199 19970300 10.1016/S0169-409X(96)00458-9 read0170980/misc/12964414 In vivo実験系による異種リポソーム間の肝取込における競合機構の解明 薬剤学 57 4 197 203 19970000 read0170980/misc/12964413 リポソームによる抗癌剤の抗腫瘍効果の最適化に関する速度論的研究 12 6 403 408 19970000 read0170980/misc/12964412 ステルスイムノリポソーム 綜合臨床 46 9 2294 2295 19970000 read0170980/misc/12964411 石田 竜弘 篠原 美加 際田 弘志 セチルマンノシド修飾リポソームへのC3フラグメントの結合における粒子径の影響 Drug Delivery System 0913-5006 12 3 155 160 19970000 10.2745/dds.12.155 read0170980/misc/12964410 リポソームの体内動態における粒子径認識機構 薬事日報社 13 2 233 240 19970000 read0170980/misc/12964371 Enhancing effect of cholesterol on the elimination of liposomes from circulation is mediated by complement activation Int. Pharm. 0378-5173 156 1 27 37 19970000 10.1016/S0378-5173(97)00174-9 read0170980/misc/12964370 Effect of Serum Components from Different Species on Destabilizing Hydrogenated Phosphatidylcholine-Based Liposomes Biol. Pharm. Bull. 0918-6158 20 8 874 880 19970000 10.1248/bpb.20.874 9300134 read0170980/misc/12964367 H Harashima TM Huong T Ishida Y Manabe H Matsuo H Kiwada Synergistic effect between size and cholesterol content in the enhanced hepatic uptake clearance of liposomes through complement activation in rats PHARMACEUTICAL RESEARCH 0724-8741 13 11 1704 1709 19961100 10.1023/A:1016401025747 8956338 read0170980/misc/12964366 K Yachi H Harashima H Kikuchi R Sudo H Yamauchi K Ebihara H Matsuo K Funato H Kiwada Biopharmaceutical evaluation of the liposomes prepared by rehydration of freeze-dried empty liposomes (FDELs) with an aqueous solution of a drug BIOPHARMACEUTICS & DRUG DISPOSITION 0142-2782 17 7 589 605 19961000 10.1002/(SICI)1099-081X(199610)17:7<589::AID-BDD976>3.0.CO;2-D 8894117 read0170980/misc/12964365 T Yamamoto M Naito H Moriyama H Umezu H Matsuo H Kiwada M Arakawa Repopulation of murine Kupffer cells after intravenous administration of liposome-encapsulated dichloromethylene diphosphonate AMERICAN JOURNAL OF PATHOLOGY 0002-9440 149 4 1271 1286 19961000 read0170980/misc/12964363 H Harashima H Kiwada Liposomal targeting and drug delivery: Kinetic consideration ADVANCED DRUG DELIVERY REVIEWS 0169-409X 19 3 425 444 19960600 10.1016/0169-409X(96)00012-9 read0170980/misc/12964409 リポソーム封入クロドロネートによるKupffer細胞の障害機序 肝類洞細胞研究の進歩 8 89-92 null null 19960000 read0170980/misc/12964408 森岡 由美 原島 秀吉 吉村 耕二 際田 弘志 リポソームの細胞内分解過程に及ぼす投与量の影響 Drug Delivery System 0913-5006 11 1 27 35 19960000 10.2745/dds.11.27 read0170980/misc/12964364 Species difference in the disposition of liposomes among mice, rats, and rabbits : Allometric relationship and species dependent hepatic uptake mechanism Pharm. Res. , 0724-8741 13 7 1049 1054 19960000 10.1023/A:1016058724452 8842043 read0170980/misc/12964362 Hideyoshi Harashima Hiroshi Kiwada Studies on the mechanism of uptake of liposomes using an isolated perfused liver system Informa Healthcare Journal of Liposome Research 0898-2104 6 1 61 75 19960000 10.3109/08982109609037202 2-s2.0-0029942607 read0170980/misc/12964361 Size-dependent release of carboxyfluorescein from cetylmannoside-modifide liposomes in human plasma Biopharm. Drug Dispos 17 145-154 null null 19960000 10.1002/(SICI)1099-081X(199603)17:2<145::AID-BDD942>3.0.CO;2-Y read0170980/misc/12964360 Is control of distribution of liposomes between tumors and bone marrow possible ? Biochimica et Biophysica Acta 1278 29-34 null null 19960000 10.1016/0005-2736(95)00188-3 read0170980/misc/12964407 リポソームによるDDS DDSの進歩1995-96 44-48 null null 19950000 read0170980/misc/12964406 小さい一枚膜リポソームの肝臓回避と癌組織集積に及ぼす膜流動性の影響 薬剤学 55 2 81 87 19950000 read0170980/misc/12964359 Size dependent liposome degradation in blood : In vivo/in vitro correlation by kinetic modeling Journal of Drug Targeting 3 253-261 null null 19950000 read0170980/misc/12964358 Effect of vesicle size on in vivo release of daunorubicin from hydrogenated egg phosphatidylcholine-based liposomes into blood circulation Biol. Pharm. Bull. 0918-6158 18 7 1020 1023 19950000 10.1248/bpb.18.1020 7581243 read0170980/misc/12964357 Effects of the size and fluidity of liposomes on their accumulation in tumors : A presumption of their interaction with tumors Int. J. Pharm. 121 195-203 null null 19950000 10.1016/0378-5173(95)00015-B read0170980/misc/12964356 Kinetic modeling of liposome degradation in peritoneal macrophages Biopharm. Drug Dispos. , 0142-2782 16 2 113 123 19950000 10.1002/bdd.2510160206 7780045 read0170980/misc/12964355 Hirotami MATSUO Chikamasa YAMASHITA Kazue AKIYAMA Hiroshi KIWADA Effect of cetylmannoside modification on the alternative complement pathway activation by liposomes in rat serum Biol. Pharm. Bull. , 0918-6158 18 4 581 585 19950000 10.1248/bpb.18.581 7655432 read0170980/misc/12964354 A NAGAYASU T SHIMOOKA H KIWADA SOLUBILIZATION BY TRITON X-100 MAKES POSSIBLE COMPLETE RECOVERY OF LIPIDS FROM LIPOSOMES IN ENZYMATIC ASSAY BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 0005-2736 1194 1 12 16 19940800 read0170980/misc/12964352 H HARASHIMA H KIWADA J KAJITA S KOBAYASHI EFFECTS OF BENIDIPINE HYDROCHLORIDE (CONIEL(R)), A NEW CALCIUM-ANTAGONIST, ON THE CARDIAC-OUTPUT, REGIONAL BLOOD-FLOW AND VASCULAR-RESISTANCE IN CONSCIOUS, SPONTANEOUSLY HYPERTENSIVE RATS BIOPHARMACEUTICS & DRUG DISPOSITION 0142-2782 15 5 431 438 19940700 10.1002/bdd.2510150509 7981431 read0170980/misc/12964405 ヒドラジン遊離薬物からのフリーラジカルの生成とアスコルビン酸の効果 磁気共鳴と医学, 5 109 112 19940000 read0170980/misc/12964404 石田 竜弘 篠原 美加 岩田 房子 大本 安一 際田 弘志 抗ヒトC3モノクローナル抗体を用いたリポソーム表面上のC3フラグメント定量 Drug Delivery System 0913-5006 9 1 25 30 19940000 10.2745/dds.9.25 read0170980/misc/12964400 リポソームによるDDS カレントテラピー, 12 4 750 755 19940000 read0170980/misc/12964353 Yoko MATSUKI Rie BANDOU Hiroshi KIWADA Harumi MAEDA Tsuyoshi GOROMARU Effects of ascorbic acid on iproniazid-induced hepatitis in phenobarbital-treated rats Biol. Pharm. Bull. , 0918-6158 17 8 1078 1082 19940000 10.1248/bpb.17.1078 7820112 read0170980/misc/12964351 H MATSUO K FUNATO H HARASHIMA H KIWADA THE COMPLEMENT-MEDIATED BUT NOT MANNOSE RECEPTOR-MEDIATED PHAGOCYTOSIS IS INVOLVED IN THE HEPATIC-UPTAKE OF CETYLMANNOSIDE-MODIFIED LIPOSOMES IN-SITU JOURNAL OF DRUG TARGETING 1061-186X 2 2 141 146 19940000 read0170980/misc/12964350 Effects of Fluidity and Vesicle Size on Antitumor Activity and Myelosuppresive Activity of Liposomes Loaded with Daunorubicin Biol. Pharm. Bull. , 0918-6158 17 7 935 939 19940000 10.1248/bpb.17.935 8000381 read0170980/misc/12964349 Sayoko OSAKA Hideki TSUJI Hiroshi KIWADA Uptake of Liposomes Surface-Modified with Glycyrrhizin by Primary Cultured Rat Hepatocytes Biol. Pharm. Bull. , 0918-6158 17 7 940 943 19940000 10.1248/bpb.17.940 8000382 read0170980/misc/12964348 Enhanced Hepatic Uptake of Liposomes Through Complement Activation Depending on the Size of Liposomes Pharm. Res. , 0724-8741 11 3 402 406 19940000 10.1023/A:1018965121222 8008707 read0170980/misc/12964347 Plasma Factor Triggering Alternative Complement Pathway Activation by Liposomes Pharm. Res. , 0724-8741 11 3 372 376 19940000 10.1023/A:1018952718496 8008701 read0170980/misc/12964346 Kinetic modeling of liposome degradation in serum : Effect of size and concentration of liposomes in vitro Biopharm. Drug Dispos. , 0142-2782 15 3 217 225 19940000 10.1002/bdd.2510150304 7880982 read0170980/misc/12964388 原島秀吉 リポソームによるDDSの設計 BIOmedica 8 5 374 379 19930000 read0170980/misc/12964387 五郎丸 毅 前田 晴美 松木 洋子 際田 弘志 キャピラリーガスクロマトグラフィによるアミノピリンの重水素標識体分離と肝機能評価への応用 RADIOISOTOPES 0033-8303 42 9 511 516 19930000 10.3769/radioisotopes.42.9_511 read0170980/misc/12964343 Distinction between the depletion of opsonins and the saturation of uptake in the dose-dependent hepatic uptake of liposomes Pharm. Res. , 0724-8741 10 4 606 610 19930000 10.1023/A:1018918623658 8483847 read0170980/misc/12964315 Distinction between the depletion of Opsonins and the sateration of uptake in the dose-dependent hepatic uptake of liposomes Pharm. Res. 0724-8741 10 4 606 610 19930000 10.1023/A:1018918623658 8483847 read0170980/misc/12964314 Kinetic analysis of AUC-dependent saturable clearance of liposomes : Mathematical description of AUC dependency J. Pharmacokin. Biopharm. 0090-466X 21 3 299 308 19930000 10.1007/BF01059781 8258769 read0170980/misc/12964313 Kinetic analysis of tissue distribution of doxorubicin incorporated in liposomes in rats(II) Biopharm. Drug Dispos. 14,595-608 null null 19930000 10.1002/bdd.2510140706 read0170980/misc/12964312 Kinetic modeling of liposome degradation in blood circulation Biopharm. Drug Dispos. 14,265-270 null null 19930000 10.1002/bdd.2510140309 read0170980/misc/12964342 H HARASHIMA Y KUME C YAMANE H KIWADA NON-MICHAELIS-MENTEN TYPE HEPATIC-UPTAKE OF LIPOSOMES IN THE RAT JOURNAL OF PHARMACY AND PHARMACOLOGY 0022-3573 44 9 707 712 19920900 read0170980/misc/12964402 ドラッグキャリアーとしてのリポソーム ライフサイエンスにおけるリポソーム・実験マニュアル, 289 314 19920000 read0170980/misc/12964394 イプロニアジドの体内動態並びにフリーラジカル中間代謝物に及ぼすアスコルビン酸の影響 薬学雑誌, 112 12 926 933 19920000 10.1248/yakushi1947.112.12_926 read0170980/misc/12964393 シメチジンのpH変化における物性の安定性 医薬ジャーナル, 28 8 1683 1685 19920000 read0170980/misc/12964392 マンノース修飾リポソームの安定性に及ぼす種差の影響 7 3 165 168 19920000 read0170980/misc/12964341 In vivo evaluation of the effect of the size and opsonization on the hepatic extraction of liposomes in rats : An application of oldendorf method Biopharm. Drug Dispos. , 0142-2782 13 7 549 553 19920000 10.1002/bdd.2510130708 1489945 read0170980/misc/12964340 Kinetic analysis of tissue distribution of doxorubicin incorporated in liposomes in rats : I Biopharm. Drug Dispos. , 0142-2782 13 3 155 170 19920000 10.1002/bdd.2510130302 1576324 read0170980/misc/12964309 Kinetic analysis of tissue distribution of doxorubicin incorporated in liposomes in rats (]G0001[) Biopharmaceutics and Drug Disposition 13 null null 19920000 10.1002/bdd.2510130302 read0170980/misc/12964305 Contribution of complement system on destabilization of liposomes composed of hydrogenated egg phosphatidylcholine in rat fresh plasma Biochimica et Biophysica Acta 0005-2728 1103 2 198 204 19920000 10.1016/0005-2728(92)90082-D 1543704 read0170980/misc/12964339 C YAMASHITA S SONE T OGURA H KIWADA POTENTIAL VALUE OF CETYLMANNOSIDE-MODIFIED LIPOSOMES AS CARRIERS OF MACROPHAGE ACTIVATORS TO HUMAN BLOOD MONOCYTES JAPANESE JOURNAL OF CANCER RESEARCH 0910-5050 82 5 569 576 19910500 10.1111/j.1349-7006.1991.tb01888.x read0170980/misc/12964307 H TSUJI S OSAKA H KIWADA TARGETING OF LIPOSOMES SURFACE-MODIFIED WITH GLYCYRRHIZIN TO THE LIVER .1. PREPARATION AND BIOLOGICAL DISPOSITION CHEMICAL & PHARMACEUTICAL BULLETIN 0009-2363 39 4 1004 1008 19910400 10.1248/cpb.39.1004 1893485 read0170980/misc/12964304 C YAMASHITA H MATSUO K AKIYAMA H KIWADA ENHANCING EFFECT OF CETYLMANNOSIDE ON TARGETING OF LIPOSOMES TO KUPFFER CELLS IN RATS INTERNATIONAL JOURNAL OF PHARMACEUTICS 0378-5173 70 3 225 233 19910400 10.1016/0378-5173(91)90286-W read0170980/misc/12964391 イソニアジドのフリーラジカル中間代謝物に及ぼすアスコルビン酸の影響 薬学雑誌 111 10 600 605 19910000 10.1248/yakushi1947.111.10_600 read0170980/misc/12964390 KUME Yoshihiro 久米義博 YAMANE Chizu 山根千鶴 HARASHIMA Hideyoshi 原島秀吉 KIWADA Hiroshi 際田弘志 Quantitative analysis of the stability of liposomes in blood in vivo. In vivo実験系における血中でのリポソームの安定性の定量的評価法 To evaluate the stability of liposomes <I>in vivo</I> is an important issue in the kinetic analysis of liposomes disposition, because the leakage of liposomal marker occurs <I>in vivo</I> blood circulation and this leads to incorrect measurement of blood concentration of intact liposomes. In this study, we developed novel quantitative method for the evaluation of the stability of liposomes in blood circulation based on the clearance concept for liposomal degradation. Inulin was used as an aqueous marker of liposomes, because it is impermeable through a biological membrane and is rapidly excreted solely by glomerular filtration. We have further examined the effect of time delay of inulin during the passage of ureter to bladder on the estimation of the free fraction, using deconvolution method. The results showed that this delay was small enough to be neglected in the practical calculation. The degradation clearance of the liposomes in <I>in vivo</I> study was calculated as [f/(1-f)·GFR], where f, GFR are the fraction of free concentration of inulin in blood, and glomerular filtrationr ate. On the other hand, the degradation clearance of the liposomes in <I>in vitro</I> study was calculated as(dose/AUC), where AUC was the area under the time course of the concentration of intact liposomes from t=0 to infinite. The <I>in vivo</I> clearance was 0.0214m<I>l</I>/min, while <I>in vitro</I> one was 0.00103m<I>l</I>/min. There was about 20-fold difference. It shows that the <I>in vitro</I> data is not appropriate for the ananlysis of <I>in vivo</I> data. This method of evaluation of liposome stability in vivo is simple and useful in the pharmacokinetic study of liposomes. The Japanese Society for the Study of Xenobiotics Drug Metabolism and Pharmacokinetics 薬物動態 0916-1139 6 2 201 208 19910000 10.2133/dmpk.6.201 read0170980/misc/12964389 Yamashita Chikamasa 山下 親正 Sone Saburo 曽根 三郎 Ogura Takeshi 小倉 剛 Kiwada Hiroshi 際田 弘志 Enhancing effect of monocytes survival by recombinant human macrophage colony-stimulating factor encapsulated in cetylmannoside-modified liposomes. マクロファージコロニー刺激因子含有マンノース修飾リポソームによるヒト単球の生存率増強効果 The present study was undertaken to examine potential value of cetlymannosides-modified multilamellar liposomes(Man-MLV)as vehicle of recombinant human macrophage colony-stimulating factor (M-CSF) to human blood monocytes. Man-MLV was taken effectively by monocytes as compared with liposomes without cetylmannoside (PC-MLV). Addition of D-mannose(50 mM) inhibited about 50% of uptake of Man-MLV by monocytes, but not significantly uptake of PC-MLV by monocytes. These results suggest that mannose redisues of Man-MLV contributes to uptake of Man-MLV by monocytes. We examined effect of encapsulation of M-CSF in Man-MLV on survival prolongation of monocytes. Blood monocytes that had been incubated for 7 days in medium with M-CSF encapsulated in Man-MLV were effective in prolongation of monocytes survival. This enhancing effect by M-CSF encapsulated in Man-MLV showed about 5-10 times higher than that in PC-MLV, in spite of the uptake of Man-MLV by monocytes was only about 2-fold different from that of PC-MLV. It was suspected that this effect contributes to not only effective uptake by monocytes, but also the difference of intracellular disposition of liposomes in monocytes. These results suggest that Man-MLV may be effective carrier vehicle in <i>in vivo</i> delivery of M-CSF to human blood monocytes. THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM 日本DDS学会 Drug Delivery System 0913-5006 6 1 19 24 19910000 10.2745/dds.6.19 read0170980/misc/12964345 Targeting to mononuclear phagocyte system by cetylmannoside-modified liposomes J. Phamacobio-Dyn. , 14 S-72 null 19910000 read0170980/misc/12964338 Saturable, non-Michaelis-Menten uptake of liposomes by the reticuloendothelial system J. Pharm. Pharmacol. , 0022-3573 43 3 162 166 19910000 10.1111/j.2042-7158.1991.tb06658.x 1675271 read0170980/misc/12964337 Hideki TSUJI Sayoko OSAKA Hiroshi KIWADA Targeting of liposomes surface-modified with glycyrrhizin to the liver I. Preparation and biological disposition Chem. Pharm. Bull. , 0009-2363 39 4 1004 1008 19910000 10.1248/cpb.39.1004 1893485 read0170980/misc/12964336 Yoko MATSUKI Yoshimatsu KATAKUSE Hiroshi MATSUURA Hiroshi KIWADA Tsuyoshi GOROMARU Effects of glucose and ascorbic acid on absorption and first pass metabolism of isoniazid in rats Chem. Pharm. Bull. , 0009-2363 39 2 445 448 19910000 10.1248/cpb.39.445 2054871 read0170980/misc/12964308 Potential value of cetylmannoside-modified liposomes as carriers of Macrophage activators to human blood monocytes Japan Journal of Cancer Research 82 null null 19910000 10.1111/j.1349-7006.1991.tb01888.x read0170980/misc/12964306 Saturable, non-Michaelis-Menten uptake of liposomes by the retuculoendothelial System Journal of Pharmacoutics and Pharmacology 43 null null 19910000 10.1111/j.2042-7158.1991.tb06658.x read0170980/misc/12964398 リポソーム製剤の臨床応用は世界的にどこまで進んでいるか 医学のあゆみ, 152 8 505 null 19900000 read0170980/misc/12964401 リポソームを利用した体内挙動の制御 生物薬剤学-最近の進歩, 399 407 19890000 read0170980/misc/12964335 Koichiro TAHARA Masahiro HAYASHI Shoji AWAZU Yuriko KATO Hiroshi KIWADA Effect of serum on dose-and temperature-dependent hepatic uptake of multilamellar vesicles(MLV) J. Pharmacobio. Dyn. , 0386-846X 12 10 596 601 19890000 10.1248/bpb1978.12.596 2630629 read0170980/misc/12964397 消化管吸収におけるドラッグデリバリーシステム 薬局, 39 9 1265 1271 19880000 read0170980/misc/12964334 HIROSHI KIWADA IWAO NAKAJIMA HIROSHI MATSUURA MITSUKO TSUJI YURIKO KATO Application of synthetic alkyl glycoside vesicles as drug carriers III. Plasma components affecting stability of the vesicles Chem. Pharm. Bull. , 0009-2363 36 5 1841 1846 19880000 10.1248/cpb.36.1841 3203422 read0170980/misc/12964333 HIROSHI KIWADA MASAMI AKIMOTO MICHIYO ARAKI MITSUKO TSUJI YURIKO KATO Application of synthetic liposomes based on acyl amino acids or acyl peptides as drug carriers I. Their preparation and transport of glutathione into the liver Chem. Pharm. Bull. , 0009-2363 35 7 2935 2942 19870000 10.1248/cpb.35.2935 3677244 read0170980/misc/12964332 Studies on the uptake mechanism of liposomes by perfused rat liver II. An indispensable factor for liver uptake in serum Chem. Pharm. Bull. , 35 3 1189 1195 19870000 read0170980/misc/12964331 HIROSHI KIWADA JUNKO SATO SUNJU YAMADA YURIKO KATO Feasibility of magnetic liposomes as a Targeting device for drugs Chem. Pharm. Bull. , 0009-2363 34 10 4253 4258 19860000 10.1248/cpb.34.4253 3829157 read0170980/misc/12964330 Effects of dose and vesicle size on the pharmacokinetics of liposomes Chem. Pharm. Bull. , 0009-2363 34 10 4244 4252 19860000 10.1248/cpb.34.4244 3829156 read0170980/misc/12964329 HIROSHI KIWADA SAKAE OBARA HIROKO NISHIWAKI YURIKO KATO Studies on the uptake mechanism of liposomes by perfused rat liver I. An investigation of effluent profiles with perfusate containing no blood component Chem. Pharm. Bull. , 0009-2363 34 3 1249 1256 19860000 10.1248/cpb.34.1249 3731343 read0170980/misc/12964396 リポソームを利用した薬物投与 -より有効なキャリアーシステムへの可能性 2 10 56 57 19850000 read0170980/misc/12964328 CA HUNT RR BURNETTE RD MACGREGOR AE STRUBBE DT LAU N TAYLOR H KIWADA SYNTHESIS AND EVALUATION OF A PROTOTYPAL ARTIFICIAL RED-CELL SCIENCE 0036-8075 230 4730 1165 1168 19850000 10.1126/science.4071041 4071041 read0170980/misc/12964327 HIROSHI KIWADA HITOSHI NIIMURA YURIKO KATO Tissue distribution and pharmacokinetic evaluation of targeting efficiency of synthetic alkyl glycoside vesicles Chem. Pharm. Bull. , 0009-2363 33 6 2475 2482 19850000 10.1248/cpb.33.2475 4064206 read0170980/misc/12964326 HIROSHI KIWADA HITOSHI NIIMURA YUICHI FUJISAKI SUNJU YAMADA YURIKO KATO Application of Synthetic alkyl glycoside vesicles as drug carrier I. Preparation and physical properties Chem. Pharm. Bull. , 0009-2363 33 2 753 759 19850000 10.1248/cpb.33.753 4017121 read0170980/misc/12964325 HIROSHI KIWADA HIROYUKI KOJIMA YURIKO KATO Correlation between in vivo and in vitro dissolution rates of(α-bromoisovaleryl)urea polymorphs Chem. Pharm. Bull. , 0009-2363 32 8 3164 3172 19840000 10.1248/cpb.32.3164 6518594 read0170980/misc/12964310 Correlation between in vivo and in vitro dissolution rate of ( α-bromoisovaleryl)urea polymorphs Chemical and Pharmaceutical Bulletin 32 null null 19840000 10.1248/cpb.32.3164 read0170980/misc/12964395 リポソームII.-ドラッグキャリアーとしてのリポソーム 細胞工学, 2 10 1251 1258 19830000 read0170980/misc/12964344 Liposomes-Are they effective drug carriers? Pharm. Int. , 4 7 181 null 19830000 read0170980/misc/12964324 HIROSHI KIWADA HIROYUKI KOJIMA YURIKO KATO Pharmacokinetic study on the polymorphs of(α-bromoisovaleryl)urea in rat Chem. Pharm. Bull. , 0009-2363 31 4 1345 1349 19830000 10.1248/cpb.31.1345 6627512 read0170980/misc/12964323 HIROYUKI KOJIMA HITOSHI NIIMURA HIROSHI KIWADA YURIKO KATO The determination of(α-bromoisovaleryl)urea in plasma and the bioavailability of its polymorphic forms in rat Chem. Pharm. Bull. , 0009-2363 30 5 1831 1836 19820000 10.1248/cpb.30.1831 7116515 read0170980/misc/12964322 HIROYUKI KOJIMA HIROSHI KIWADA YURIKO KATO The dissolution properties and physico-chemical properties of polymorphic forms of(α-bromoisovaleryl)urea Chem. Pharm. Bull. , 0009-2363 30 5 1824 1830 19820000 10.1248/cpb.30.1824 read0170980/misc/12964321 HIROSHI KIWADA SHOJI AWAZU MANABU HANANO The study on the biological fate of paraben at the dose of practical usage in rat III. The effect of salicylic acid on the fate of paraben J. Pharmacobio. Dyn. , 0386-846X 4 8 643 648 19810000 10.1248/bpb1978.4.643 7299628 read0170980/misc/12964320 HIROSHI KIWADA SHOJI AWAZU MANABU HANANO The Study on the biological fate of paraben at the dose of practical usage in rat II. The phamacokinetic study on the blood concentration after the administration of ethyl paraben or p-hydroxybenzoic acid J. Pharmacobio. Dyn. , 0386-846X 3 7 353 363 19800000 10.1248/bpb1978.3.353 read0170980/misc/12964319 HIROSHI KIWADA KAZUO TAKAMI YURIKO KATO The preparation and properties of a new polymorphic form of(α-bromoisovaleryl)urea Chem. Pharm. Bull. , 0009-2363 28 5 1351 1356 19800000 10.1248/cpb.28.1351 read0170980/misc/12964318 HIROSHI KIWADA SHOJI AWAZU MANABU HANANO The study on the biological fate of parabens at the dose of practical usage in rat I. The metabolism and excretion of ethyl-hydroxybenzoate(ethyl paraben)and p-hydroxybenzoic acid J. Pharmacobio. Dyn. , 0386-846X 2 6 356 364 19790000 10.1248/bpb1978.2.356 read0170980/misc/12964317 HIROSHI KIWADA MASAHIRO HAYASHI TOHRU FUWA SHOJI AWAZU MANABU HANANO The pharmacokinetic study on the fate of 8-hydroxyquinoline in rat Chem. Pharm. Bull. , 0009-2363 25 7 1566 1573 19770000 10.1248/cpb.25.1566 409509 read0170980/misc/12964316 HIROSHI KIWADA KANAME MORITA MASAHIRO HAYASHI SHOJI AWAZU MANABU HANANO A new numerical calculation method for deconvolution in linear compartment analysis of phamacokinetics. Chem. Pharm. Bull. , 0009-2363 25 6 1312 1318 19770000 10.1248/cpb.25.1312 890855 read0170980/misc/12964311 A new numerical calculation method for deconvolution in linear compartment analysis of pharmacokinetics Chemical and Pharmaceutial Bulletin 25 null null 19770000 10.1248/cpb.25.1312 read0170980/misc/12964403 有効性の向上とバイオアベイラビリティー 総合製剤学, null null read0170980/misc/12964399 全身循環性ドラッグキャリアーは可能か? 生命とくすり, 2 null read0170980/books_etc/1799019 Liposomes : Are they effective drug carriers? Topics in Pharmaceutical Sciences 1983, ed. D. D. Breimer and P. Speiser 19830000