Deconjugative Esterification of 2-(4-Phenylcyclohexylidne)acetic Acid via Intramolecular Chirality Transfer


A Microwave-Assisted Deconjugative Esterification of α,β-Unsaturated Carboxylic Acids through alpha,beta-Unsaturated Ketene Intermediates


Reinvestigation of the Synthesis of Isoliquiritigenin (ILG): Application of Horner-Wadsworth-Emmons Reaction and Claisen-Schmidt Condensation

Isoliquiritigenin [ILG, (E)-1] was readily prepared via the Horner-Wadsworth-Emmons reactions using β-ketophosphonates 5a, b. An improved protocol for the synthesis of (E)-1 via the Claisen-Schmidt condensation was also presented.


Modified Cinchona Alkaloid-Zinc Complex Catalysts: Enantioselective Monoacetylation of Glycerol Derivatives with Acetic Anhydride


A Chiral Bifunctional Sulfonamide as an Organocatalyst: Alcoholysis of -Symmetric Cyclic Dicarboxylic Anhydrides


Synthesis and Reaction of 1-Azabicyclo[3.1.0]hexane

The effective formation of 1-azabicyclo[3.1.0]hexane (5) by treatment of 2-(bromomethyl)pyrrolidine hydrobromide (4) with n-BuLi was established, with the reaction occurring by a rational reaction pathway via the open chain transition state 8 based on intermolecular Br...Li(+) coordination (SN2 process). The reaction of 5 with electrophiles 13a-n gave the corresponding pyrrolidines 14a-n and piperidine 6, 15a-g, i-n. The selectivity of the products in this reaction appeared to be controlled by equilibrium.


Reaction of 1-Azabicyclo[1.1.0]butane with Activated Amides


Use of Diketopiperazines for Determining Absolute Configurations of α-Substituted Serines by 1H-NMR Spectroscopy


Chemoenzymatic Synthesis of α-Substituted Serines via Enantiodivergent Transformation


Intramolecular Nonbonded S---N Interaction in Rabeprazole

Intramolecular nonbonded S...N interactions in the crystal structures of the derivatives (7a-d) of sodium rabeprazole (1) and an intermolecular nonbonded S...N interaction between ethylmethylsulfoxide and pyridine in a solution were recognized. These results made us estimate that the intramolecular nonbonded S...N interaction existed in 1 and its derivatives in a solution, and formed the 4-membered quasi-ring in 2 (Fig. 1) followed by the increase of the reactivity of 2 to give the putative spiro sulfoxide 3, which is the key intermediate in the reaction cascade of 1 (Chart 1).


Synthesis of New Quinolone Antibiotics Utilizing Azetidine Derivatives Obtained from 1-Azabicyclo[1.1.0]butane

A series of 3-sulfenylazetidine derivatives 5a-f were synthesized via the ring-opening reactions of 1-azabicyclo[1.1.0]butane (ABB, 3) with thiols 4a-f in 50-92% yields. Treatment of ABB (3) with aromatic amines 9a-e and dibenzylamine (9f) in the presence of Mg(ClO4)2 afforded the corresponding 3-aminoazetidine derivatives 10a-f in 24-65% yields. N-Benzyl-3-bromoazetidine (13), which was obtained by the reaction of ABB (3) with benzyl bromide, gave 3-aliphatic amino-substituted azetidine derivatives 15a, b. Novel fluoroquinolones 7a-f, 11a-f, 16a, b and 25a-c were obtained by the introduction of these azetidine derivatives into the C7 position of a quinolone nucleus 6 and N1-heterocyclic quinolones 21a-c in 21-83% yields. Some of them exhibited a greater antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) in comparison with that of clinically used fluoroquinolone, levofloxacin (LVFX).


Effects of Magnesium Salts and Amines on the Stereoselectivity in the Imine Aldol Reaction

In the imine aldol reactions of 1 with aromatic aldehydes using magnesium salts in the presence of amines, the threo/erythro ratios of products increased in the order Mg(ClO4)2>MgI2>MgBr2>MgCl2>Mg(OTf)2 and N,N,N',N'-tetramethylethylenediamine (TMEDA)>Et3N. This increase in the threo/erythro ratios of products was estimated to be caused by a retro-imine aldol reaction under thermodynamic control.


Nonenzymatic Enantioselective Monoacetylation of Prochiral 2-Protectedamino-2-alkyl-1,3-propanediols Utilizing a Chiral Sulfonamide-Zn Complex Catalyst

[structure: see text] Treatment of a chiral sulfonamide with Et(2)Zn gave quantitatively its Zn complex and then the structure was determined by X-ray crystallographic analysis. Reaction of prochiral N-Boc-2-amino-2-alkyl-1,3-propanediols with Ac(2)O in the presence of 5 mol % of chiral sulfonamide-Zn complex catalyst afforded the corresponding chiral monoacetyl products in 70-92% yields with 70-88% ee values. The proposed mechanism for the catalytic monoacetylation of a prochiral 1,3-propanediol was presented on the basis of CSI-MS analysis.


Stereoselective Synthesis of Unsymmetrical Conjugated Dienes and Trienes Utilizing Silacyclobutenes


Synthesis and Antibacterial Activities of New Quinolone Derivatives Utilizing 1-Azabicyclo[1.1.0]butane

The ring-opening reactions of 1-azabicyclo[1.1.0]butane 3 with thiols 6a-f gave 3-sulfenylazetidine derivatives 7a-f in 50-92% yields. Treatment of 3 with aromatic amines 11a-e and dibenzylamine 11f in the presence of Mg(ClO(4))(2) afforded the corresponding 3-aminoazetidine derivatives 12a-f in 24-53% yields. These azetidine derivatives were introduced into the C7 position of a quinolone nucleus 8 to afford the corresponding fluoroquinolones 9a-f and 13a-f in 21-83% yields. Some of them exhibited superior antibacterial activity against quinolone-susceptible MRSA in comparison with clinically used fluoroquinolones, such as levofloxacin, ciprofloxacin, and gatifloxacin.

Bioorganic & Medicinal Chemistry Letters


Synthesis of Novel Silacyclobutene Derivatives Utilizing Zirconocene- and Titanocene-ethylene Complexes


Tandem Reduction Olefination of Triethyl 2-Aceyl-2-fluoro-2-phosphonoacetates and a Synthetic Approach to Cbz-Gly-Ψ[(Z)-CF=C]-Gly Dipeptide Isostere


Novel Deconjugative Esterification of 2-Cyclohexylidneacetic Acids through 4-(Pyrrolidin-1-yl)pyridine Catalyzed Carbodiimide Couplings


Diastereoselective Horner-Wadsworth-Emmons Reaction for the Synthesis of Tetrasubstituted Alkenes with an Axis of Chirality


Practical Synthesis of New Chiral cis-Phthalazinones with Potential for High Phosphodiesterase (PDE-4) Inhibitory Activity


Lipase-catalyzed Enantioselective Acetylation of Prochiral N-Cbz-2-Alkyl-2-amino-1,3-propanediols and Enantiodivergent Synthesis of α-Benzylserine


Fab fragment labeled with ICG-derivative for detecting digestive tract cancer


A Novel and Efficient Darzens Reaction Catalyzed by Magnesium Bromide


Optimal Labeling Condition of Antibodies Available for Immunofluorescence Endoscopy

In recent years, labeled antibodies have been used for diagnostic imaging in many studies. In this study, we investigated the mode of binding in antibodies labeled with ICG derivatives newly developed for the diagnosis of microcarcinomas, and evaluated the optimal binding molar ratio between the labeling compounds and antibody. MUC 1 antibody and ICG derivatives (ICG-ATT and ICG-sulfo-OSu) were used. ICG derivatives non-covalently bound to the antibody were removed with ethyl acetate, and the ratio of ICG derivatives covalently bound to the labeled antibody was confirmed. During purification of the labeled antibody, the amount of each labeling compound reacting with 1 molecule of the antibody varied as follows: 4, 8, 16, and 32 molar equivalents. Subsequently, the intensity of fluorescence was evaluated by spectroscopy and infrared fluoroscopy. The ratio of residual ICG derivative labeling the antibody was 67.4% for ICG-ATT and 65.0% for ICG-sulfo-OSu. When fluorescent antibody labeled with ICG-ATT at an F/P ratio of 2.94 or 4.18 was used, specific and clear fluorescent images of the antigen were obtained. When ICG-ATT-labeled antibody at an F/P ratio of 6.50 or 6.75 was used, the fluorescence intensity decreased and the fluorescent images of antigen became unclear. It was found that the ICG-ATT-labeled antibody was a more specific and sensitive marker than ICG-sulfo-OSu-labeled antibody, and that lower binding molar ratios of ICG-ATT were more useful for labeling the antibody.

The Journal of Medical Investigation : JMI


Expeditious Syntheses of Conjugated Allenyl Esters and Oxazoles through a Cascade Reaction of α-Alkynyl Malonates under Alkaline Conditions

Diethyl alpha-alkynyl-alpha-methoxymalonates (2a--e) were smoothly hydrolyzed and then decarboxylated under alkaline conditions employing 1 N KOH in EtOH to give conjugated allenyl esters (6a--e) in high yields, and similar alkaline treatment of diethyl alpha-alkynyl-alpha-acetylaminomalonates (5a, b, d, e) furnished unexpectedly the oxazoles (7a, b, d, e) having three substituent groups in excellent yields.


Highly Stereoselective Asymmetric Pummerer Reactions That Incorporate Intermolecular and Intramolecular Nonbonded S---O Interactions

New chiral sulfoxides (R(S),S)-3, (S(S),S)-3, (R(S),S)-4, and (S(S),S)-4 and known chiral sulfoxides (R(S))-5, (R(S))-6, and (R(S))-7 were synthesized, and the stereochemistry of the new sulfoxides (R(S),S)-3 and (R(S),S)-4 was determined by X-ray crystallographic analysis. In their crystallographic structures, the intramolecular nonbonded S...O close contacts were recognized. Analyses of several sulfoxide complexes including rac-11 with N,N-dimethylacetamide (DMAC) or N-methyl-2-pyrrolidone (NMP) in a MeOH solution utilizing cold-spray ionization mass spectrometry provided, for the first time, direct information for intermolecular nonbonded S...O interactions between sulfoxides and amide (or lactam) in a solution. Highly diastereoselective and enantioselective Pummerer reactions based on the concept of intermolecular and intramolecular nonbonded S...O interactions were performed by treatment of several chiral sulfoxides (R(S), S)-3, (S(S), S)-3, (R(S), S)-4, (S(S), S)-4, (R(S))-5, (R(S))-6, and (R(S))-7 with acetic anhydride and trimethylsilyl triflate (TMSOTf) in DMAC, NMP, N,N-dimethylformamide, and N-formylpiperidine. Mechanistic studies on these facile stereoselective Pummerer reactions revealed the necessity for the amide/TMSOTf complex, such as 26 or 27, to be an efficient activation reagent for Ac(2)O and a trapping reagent for the released acetate ion, and that DMAC and NMP had a positive effect on this highly stereoselective chiral transfer reaction.

Journal of the American Chemical Society


Highly Enantioselective Catalytic Thiolysis of Prochiral Cyclic Dicarboxylic Anhydrides Utilizing a Bifunctional Chiral Sulfonamide


Practical Synthesis of Chiral cis-Cyclohex-4-ene-1,2-dicarboxylic Acid Derivatives by Utilizing (4S)-Isopropyl-1,3-thiazolidine-2-thione


A Facile Synthesis of Novel Chiral Phosphonoacetates Bearing a Stereogenic Phosphorus Atom

Novel chiral phosphonoacetates bearing a stereogenic phosphorus atom were successfully synthesized by enzyme-catalyzed kinetic resolution of racemic phosphonoacetates.


Trimethylaluminum-Induced Diastereoselective Methylation onto Ethyl 2-Oxocyclopentane-1-carboxylate and Isomerization between Both of the Dimethylaluminium-Alkoxide Products


Facile Generation Method for Conjugated Allenyl Esters Based on retro-Dieckmann Type Ring-Opening Reactions


New Ring-Expansion Reactions of Hydroxy Propenoyl Cyclic Compounds under Palladium(0)/Phosphine-Catalyzed Conditions

[reaction: see text] Palladium(0)-catalyzed one-atom ring-expansion of 1-hydroxy-2,2-dialkyl-1-propenoylindan derivatives has been achieved in the presence of P(o-tolyl)(3) giving 2-hydroxy-3,3-dialkyl-2-vinyl-1-tetralone derivatives in excellent yields. This ring-expansion reaction was applied to a 17-(1-oxo-2-propenyl)-beta-estradiol derivative and furnished a similar ring-expanded product in an excellent yield.


New Synthetic Methods for Seven- and Eight-Membered Cyclic Ethers Based on the Ring-Expansion Reactions of Hydroxy or Lithioxy Methoxyallenylisochroman Derivatives


Mechanistic considerations for the consecutive cyclization of 2,3-dibromopropylamine hydrobromide giving a strained molecule, 1-azabicyclo[1.1.0]butane

The effective formation of 1-azabicyclo[1.1.0]butane (2) by treatment of 2,3-dibromopropylamine hydrobromide (1) with n-BuLi could be understood considering a rational reaction pathway via both transition states 10 and 19 based on the intramolecular Br⋯Li^+ coordination. A similar cyclization pathway starting from N-benzyl-3-bromopropylamine hydrochloride (17) to afford yV-benzylazetidine (18) could also be postulated on the basis of a transition state 20 involving the intramolecular Br⋯Li^+ coordination.


Intramolecular Nonbonded S---O Interaction in Acetazolamide and Thiadiazolinethione Molecules in Their Dimeric Crystalline Structures and Complex Crystalline Structures with Enzymes


A New Infrared Fluorescent-Labeling Agent and Labeled Antibody for Diagnosing Microcancers

We have developed infrared fluorescent labeling agents and infrared-ray fluorescence endoscopes to establish a novel diagnostic technique. Since the fluorescence intensity of the initial labeled antibody (ICG-sulfo-OSu-labeled antibody) was not sufficient for practical use, we synthesized indocyanine green acylthiazolidinethione (ICG-ATT), which was expected to label various target molecules having amino groups efficiently. To confirm imaging of infrared fluorescence intensity of ICG-ATT- and ICG-sulfo-OSu-labeled anti-MUC1 antibodies, cotton thread was soaked in various concentrations of the antibody solution in 0.1M PBS, and observed under the epi-illumination infrared fluorescence microscope. Localization and the intensity of infrared fluorescence and DAB coloring was compared in paraffin sections of human gastric mucosa. In the study of cotton threads, both labeled antibodies showed relatively clear infrared fluorescence, and significant difference was not observed between the two antibodies. ICG-ATT-labeled anti-MUC1 antibody produced stronger staining than that by ICG-sulfo-OSu-labeled antibody. Localization pattern of infrared fluorescent staining was in good agreement with that by the conventional method with oxidized DAB staining. ICG-ATT is useful as a fluorescent-labeling agent for diagnosis of microcancers by infrared fluorescence endoscopes.


Asymmetric Horner-Wadsworth-Emmons Reaction Utilizing Isomannide and Isosorbide Derivatives as Chiral Auxiliaries


Tandem Reduction-Olefination for the Stereoselective Synthesis of (Z)-α-Fluoro-α,β-unsaturated Esters


(E)-Selective Horner Wadsworth Emmons reaction of aldehydes with bis-(2,2,2-trifluoroethyl)phosphonoacetic acid


A New Convenient Method for Synthesis of 3-(2-Oxoethylidene)isoindolin-1-ones Employing Palladium(II) Acetate and DDQ


(E)-Selective Horner-Wadsworth-Emmons Reaction of Aryl Alkyl Ketones with Bis(2,2,2-trifluoroethyl)phosphonoacetic Acid


A Facile Method for the Stereoselective Horner-Wadsworth-Emmons Reaction of Aryl Alkyl Ketones

Excellent Z or E selectivity was observed in the Horner-Wadsworth-Emmons (HWE) reactions of methyl bis(2,2,2-trifluoroethyl)phosphonoacetate or ethyl 2-fluoro-2-diethylphosphonoacetate with aryl alkyl ketones bearing substituents on an aromatic moiety employing Sn(OSO_2CF_3)_2 in the presence of N-ethylpiperidine.


Synthesis of New Chiral Sulfinyldiacetic Acid Derivatives and Attempt at Chemoselective Asymmetric Pummerer Reaction

(R_s)-1 (85% ee) was prepared by utilizing a porcin pancreatic lipase-promoted hydrolysis of sulfinyldiacetic acid dimethyl ester (8) which was derived from thiodiacetic acid (7). (R_s)-1 (99% ee) and (S_s)-1 (99% ee) were readily obtained by methanolysis of (R_s,S)-12 and (S_s,S)-12 with MeONa in MeOH. (R_s,S)-12 and (S_s,S)-12 were furnished by chromatographic separation of the diastereomeric mixture, obtained by oxidation of thiodiacetic mono-carboxylic acid (11) with 30% H_2O_2 followed by dehydrative condensation of the resultant sulfinyldiacetic mono-carboxylic acid with 4(S)-isopropyl-1,3-thiazolidine-2-thione. (R_s)-1 (99% ee) was successively treated with (TMS)_2NLi, Ac_2O, and TMSOTf to give a major chiral-3 product in 75% ee and in a highly chemoselective manner (chiral-3 : chiral-2=93 : 7).


Remarkable Discrepancy in the Predominant Structures of Acyl(or Thioacyl)aminothiadiazoles, Acyl(or Thioazyl)aminooxadiazoles and Related Compounds Having the Potential for Rotational, Geometrical and Tautomeric Isomerism


Facile Palladium(0)-Catalyzed Ring Expansion Reactions of Hydroxy Methoxyallenyl Cyclic Compounds via Hydropalladation

Palladium(0)-catalyzed one-atom ring expansion of various hydroxy methoxyallenyl compounds has been achieved in excellent yields without the use of aryl halides. Hydroxy methoxyallenylisoindolinones, -indanones, and -phthalans have been readily converted to the corresponding isoquinolones, naphthoquinones, and isochromanones in the presence of P(o-tolyl)(3).


Highly Chemoselective Pummerer Reactions of Sulfinyldiacetic Acid Derivative


Enantioselective Horner-Wadsworth-Emmons Reaction for the Asymmetric Synthesis of α-Fluoro-α,β-unsaturated Esters


Stereoselective Synthesis of Tetrasubstituted (Z)-Alkenes form Aryl Alkyl Ketones Utilizing the Horner-Wadsworth-Emmons Reaction


Toward (Z)-Selective Horner-Wadsworth-Emmons Reaction of Aldehydes with 2-Fluoro-2-diethylphosphonoacetic Acid


Synthesis and Antibacterial Activity of New 1β-Methylcarbapenems Having the Potential for Intramolecular Nonbonded S---O Interactions

Mercaptoacetyliminothiadiazoline derivatives (19, 20) useful for the pendant moiety of 1beta-methylcarbapenem antibiotics were efficiently synthesized. Acetyl derivative (18) of 20 was submitted to X-ray analysis, and a significant nonbonded S...O close contact was recognized in the crystallographic structure. New 1beta-methylcarbapenems (5, 6) were synthesized by exploiting 19 and 20, and exhibited considerable antibacterial activities in vitro.


Copper(I) Iodine-Promoted Hydroxylation onto the Lithium or Potassium Enolate of Lactones and Lactams


Chemoenzymatic Total Synthesis of (+)-Conagenin, a Low-molecular-weight Immunomodulator


Asymmetric Syntheses of (+)-Camptothecin and (+)-7-Ethyl-10-methoxycamptothecin


Synthesis of a New Class of Cathepsin B Inhibitors Exploiting a Unique Reaction Cascade


Desulfurilative Self-Coupling Reaction of 1,3-Thiazolidine-2-thiones and Intramolecular Non-Bonded S---S Interaction in the Crystallographic Structure of the Products


Tin-Mediated Enantioselective Aldol-Type Reaction for the Asymmetric Synthesis of α-Substituted Serines Utilizing an External Chiral Ligand, (-)-Sparteine


Novel hetrocyclic ring-expansion and/or dehydration-hydration reactions of propargylic and allenylic hydroxy γ-lactams in the presence of strong base or Lewis acid


New Reaction Mode of the Horner-Wadsworth-Emmons Reaction for the Preparation of α-Fluoro-α,β-unsaturated Esters


Intramolecular Nonbonded S---O Interaction Recognized in (Acylimino)thiadiazoline Derivatives as Angiotensin II Receptor Antagonists and Related Compounds

Journal of the American Chemical Society


Synthesis and Antibacterial Activity of New, Non-natural 1β-Methylcarbapenem Bearing a σ-Symmetric Bicyclopyrazoliumthio Group as the Pendant Moiety


New Enantiodivergent Procedure for the Syntheses of Chiral α-Substituted Serines from α-Alkyl-α-aminomalonates Utilizing Enzymatic Hydrolysis


Synthesis and Reactivities of 3-Indocyanine-green-acyl-1,3-thiazolidine-2-thione (ICG-ATT) as a New Near-Infrared Fluorescent-labeling Reagent


Tin- or Magnesium-Mediated Diastereoselective Aldol-Type Reactions for the Asymmetric Synthesis of α-Substituted Serines


Quantitative structure-activity relationships of benzoyliminothiadiazoline derivatives as angiotensin II receptor antagonists

Bioorganic & Medicinal Chemistry Letters


Efficient, Direct Synthesis of Novel Racemic Trimethoxy-Substituted [6] and


New Reaction Mode of the Horner-Wadsworth-Emmons Reaction Using Sn(OSO2CF3)2


Asymmetric Dihydroxylation onto the α,β-Unsaturated Carboxylic Ester Derivatives of Camptothecin


Variable Stereoselectivity in the Imine Aldol Reactions Employing MgBr2 and Et3N


Cycloaromatization of enediyne model compounds via a reaction cascade triggered by hydrolysis of the a-alkynylmalonates


A New Ring Enlargement Reaction of γ-Lactones to Seven-Membered Cyclic Ethers via


Syntheses and Reactions of the Diethyl α-Alkynylmalonates Involving the Generation of


A New Enantiodivergent Procedure Utilising the Chemoselective Dieckmann-Type


Synthesis and Biological Evaluation of 3,4-Diphenyl-1,2-dihydroisoquinolines as a New Tamoxifen Analogue

3,4-Diphenyl-1,2-dihydroisoquinoline derivatives (1) as a new tamoxifen analogue were synthesized with trifluoromethanesulfonic acid from 3,4-diphenyl-1,2,3,4-tetrahydroisoquinolin-4-ols (2), which were prepared by intramolecular Barbier reaction of N-(2-iodobenzyl)phenacylamines. Anti-proliferative activities of 1 and 2, and 3,4-diphenyl-1,2,3,4-tetrahydroisoquinolines (3) prepared by NaBH4 reduction of 1 against human mammary carcinoma MCF-7 cell line and human nasopharyngeal carcinoma KB cell line were evaluated. 1,2-Dihydroisoquinoline (1a) was the most active against MCF-7 cells in the compounds tested and the activity [IC50(micrograms/mL) 0.94] was nearly equipotent to that of tamoxifen. The structure-activity relationships of the compounds 1,2 and 3 were discussed.


Synthesis and Enantioselectivity of Optically Active 1- and 3-Substituted 4-Phenyl-1,2,3,4-tetrahydroisoquinolin-4-ols and Related Compounds as Norepinephrine Potentiators


A New Synthesis of 3-Substituted Indolines and Indoles


New Reaction Mode of the Dieckmann-Type Cyclization under the Lewis Acid-Et3N


Asymmetric Total Synthesis of ISP-I (Myriocin, Thermozymocidin), a Potent


Lewis Acid- and Cationic Lithium-Mediated Diastereoselective Aldol-Type Reaction Based


New Norepinephrine Potentiators:Synthesis and Structure-Activity Relationships of a series of 4-Phenyl-1,2,3,4-tetrahydroisoquinolin-4-ols


Synthesis and Pharmacological Evaluation of Phenolic 2-Methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-4-ols


Isolation and Structure Elucidation of a Novel Alkaloid, Incartine, a Supposed Biosynthetic Intermediate, from Flowers of Lycoris incarnata


New Six- to Eight-Membered-Ring Formation Based on the Intramolecular Endo- Mode


Enzymatic Hydrolyses of the σ-Symmetric Dicarboxylic Diesters Bearing a Sulfinyl Group


A Facile Synthesis of New Prostaglandin Analogues by Utilizing the Characteristics of the


One-Pot Synthesis of New 1,3-Imidazolidines Possessing Three Aryl Groups via a 1,3-


Synthesis of New Molecules Adopting a Unique Sigmoid Conformation with Stacked


Characterization of the Sulfonic Esters Adopting a Folded Conformation with Stacked


Different Mechanisms of Action of Long Chain Fatty Acid Esters of Podophyllotoxin and


Biomimetic, Chemical, and Spectroscopic Evaluations for the Radiosensitizing Potential of


Radiosensitizing Hypoxic Cells with New 3-Nitro-1,2,4-triazole Derivatives in Vitro and


Effect of Oridonin, a Rabdosia Diterpenoid, on Radiosensitization with Misonidazole


Synthetic Development of Hypoxic Cell Sensitizers Having 3-Nitrotriazole Moiety


Evaluation of the Affinity of New N Atom-Containing Tumor Inhibitors for Nucleic Acids

Nucleic Acids Research, Symposium Series