label: url

en: Liposomes Methods and Protocols (3rd Edition) --- The Post-insertion Method for the Preparation of PEGylated Liposomes

en: Springer

ja: Springer

en: PEGylation is a crucial process for decorating the surface of liposomes with polyethylene glycol (PEG) for clinical use. This process endows the liposomes extended circulation time and improved stability in vivo. The post-insertion method is one of the well-established techniques for PEGylation. This method requires only one-step incubation to accomplish the transfer of PEGylated lipids from PEGylated lipid-based micelles into the membranes of preformed liposomes.


en: 中分子医薬品やDDSに対する免疫応答

ja: 中分子医薬品やDDSに対する免疫応答

en: CMC Publishing Co.,Ltd.

ja: 株式会社 シーエムシー出版


en: ナノフィブリル化バクテリアセルロースの生産とその応用

ja: ナノフィブリル化バクテリアセルロースの生産とその応用

en: NTS Inc.

ja: 株式会社エヌ·ティー·エス


en: タンパクやナノ粒子に対するPEG修飾の有用性と免疫系に与える影響

ja: タンパクやナノ粒子に対するPEG修飾の有用性と免疫系に与える影響

en: Technical Information Institute Co., Ltd.

ja: 株式会社 技術情報協会


en: Immunogenicity against PEGylated proteins, in Polymer-protein conjugates: From PEGylation and beyond (Chapter 5)

en: Elsevier Inc.

ja: Elsevier Inc.


en: 発酵ナノセルロースの大量生産とその応用

ja: 発酵ナノセルロースの大量生産とその応用

en: Nankodo

ja: 南江堂


en: Accelerated blood clearance phenomenon and complement activation-related pseudoallergy: two sides of the same coin

en: Pan Stanford Publishing

ja: Pan Stanford Publishing


en: Anti-PEG immunity against PEGylated therapeutics.


en: The accelerated blood clearance (ABC) phenomenon of PEGylated nanocarriers.


en: Anti-PEG IgM production via a PEGylated nano-carrier system for nucleic acid delivery


en: Immune response to PEGylated nanomedicines: Impact of IgM Response

en: The Springer International Publishing AG


en: PEGylation and anti-PEG antibodies.

ja: PEGylation and anti-PEG antibodies.


en: ドラッグデリバリーシステム(DDS,薬物送達システム)

ja: ドラッグデリバリーシステム(DDS,薬物送達システム)


en: ドラッグデリバリーシステム(DDS)

ja: ドラッグデリバリーシステム(DDS)

en: 京都廣川書店

ja: 京都廣川書店


en: Liposomal nanomedicine

ja: Liposomal nanomedicine

en: World Scientific

ja: World Scientific


en: 腫瘍内微小環境の能動的制御に基づくDDSの開発とがん治療への応用

ja: 腫瘍内微小環境の能動的制御に基づくDDSの開発とがん治療への応用

en: CMC Publishing Co.,Ltd.

ja: 株式会社 シーエムシー出版


en: Anti-PEG IgM production via a PEGylated nano-carrier system for nucleic acid delivery.

en: Springer

en: For the systemic application of nucleic acids such as plasmid DNA and small interfering RNA, safe and efficient carriers that overcome the poor pharmacokinetic properties of nucleic acids are required. A cationic liposome that can formulate lipoplexes with nucleic acids has significant promise as an efficient delivery system in gene therapy. To achieve in vivo stability and long circulation, most lipoplexes are modified with PEG (PEGylation). However, we reported that PEGylated liposomes lose their long-circulating properties when they are injected repeatedly at certain intervals in the same animal. This unexpected and undesirable phenomenon is referred to as the accelerated blood clearance (ABC) phenomenon. Anti-PEG IgM produced in response to the first dose of PEGylated liposomes has proven to be a major cause of the ABC phenomenon. Therefore, in a repeated dosing schedule, the detection of anti-PEG IgM in an animal treated with PEGylated lipoplex could be essential to predict the occurrence of the ABC phenomenon. This chapter introduces a method for the evaluation of serum anti-PEG IgM by a simple ELISA procedure, and describes some precautions associated with this method.


en: 新しい剤形:ドラッグデリバリーシステム

ja: 新しい剤形:ドラッグデリバリーシステム


en: Cationic liposomes and tumour vasculature targeting: a therapeutic approach that has potential for solid tumours.

en: Souto, E.B. (Ed.), i-Smithers - Creative Publishing Solutions


en: Breaking the barriers to tumor-targeting via nanocarrier-based drug delivery to the tumor microenvironment.

en: Nova Science Publishers

ja: Nova Science Publishers


en: Complexation of siRNA and pDNA with cationic liposomes: The important aspects in lipoplex preparation.

en: A chapter, Liposomes, Methods Mol. Biol.

en: In the last two decades, cationic liposomes have been investigated as vehicles for nucleic acids [plasmid DNA (pDNA) and small interfering RNA (siRNA)] delivery in vitro and in vivo. The formation of cationic liposomes-nucleic acids complexes, termed lipoplexes, depends on a number of experimental variables. The quality of the nucleic acid and the cationic liposome as well as the selection of diluents for diluting the concentrated stocks strongly affect the resulting lipoplexes and their efficiency of gene-expression or gene-silencing effect following transfection. In addition, the molar ratio of cationic lipid nitrogen (N) to siRNA or pDNA phosphate (P) (N/P ratio) influences the final characteristics of the lipoplexes, such as size, surface zeta potential, and reproducibility, thereby reflecting their efficiency following transfection. The methods presented in this chapter could be helpful to obtain reliable and reproducible lipoplexes and experimental results.


en: Synergistic antitumor activity of metronomic dosing chemotherapy in combination with liposomal anticancer drug.


en: Unexpected reactions by in vivo application of PEGylated liposomes.

en: Springer Science + Business Media, New York, USA


en: 第10章医学薬学でのリポソーム応用 1節リポソームと細胞の相互作用

ja: 第10章医学薬学でのリポソーム応用 1節リポソームと細胞の相互作用

en: NTS Inc.

ja: 株式会社エヌ·ティー·エス


en: 第10章医学薬学でのリポソーム応用 3節長期血中滞留性リポソーム

ja: 第10章医学薬学でのリポソーム応用 3節長期血中滞留性リポソーム

ja: 株式会社エヌ·ティー·エス