misc
"タイトル(日本語)","タイトル(英語)","著者(日本語)","著者(英語)","担当区分","概要(日本語)","概要(英語)","出版者・発行元(日本語)","出版者・発行元(英語)","出版年月","誌名(日本語)","誌名(英語)","巻","号","開始ページ","終了ページ","記述言語","査読の有無","招待の有無","掲載種別","国際・国内誌","国際共著","DOI","ISSN","eISSN","URL","URL2","主要な業績かどうか","公開の有無"
"最新のトピックス:イソインドールが分子と分子をつなぐ!ーオルトフタルアルデヒド法の新展開","最新のトピックス:イソインドールが分子と分子をつなぐ!ーオルトフタルアルデヒド法の新展開","佐野 茂樹","Shigeki Sano","null","null","null","null","null","2023-11","化学","化学","Vol.78","No.11","62","63","jpn","null","null","introduction_scientific_journal","null","null","null","0451-1964","null","null","null","null","null"
"総説 がんを標的とした内視鏡分子イメージングの新展開","Recent Advances in Endoscopic Molecular Imaging of Gastrointestinal Cancer","六車 直樹, 藤本 将太, 樫原 孝典, 三橋 威志, 宮本 佳彦, 岡本 耕一, 中尾 允泰, 佐野 茂樹, 高山 哲治","Naoki Muguruma, 藤本 将太, 樫原 孝典, 三橋 威志, 宮本 佳彦, Koichi Okamoto, Michiyasu Nakao, Shigeki Sano, Tetsuji Takayama","null","null","null","null","null","2020-09-10","OPTRONICS","OPTRONICS","Vol.39","No.9","117","121","jpn","null","null","introduction_scientific_journal","null","null","null","0286-9659","null","null","null","null","null"
"Chemistry of 2.5-Diketopiperazine and its Bis-lactim Ether: a Brief Review","Chemistry of 2.5-Diketopiperazine and its Bis-lactim Ether: a Brief Review","Shigeki Sano, Michiyasu Nakao","Shigeki Sano, Michiyasu Nakao","null","2,5-Diketopiperazines have attracted much attention because of their biological activities and molecular structure characteristics. Bis-lactim ethers derived from these 2,5-diketopiperazines include well-known organic molecules such as Schöllkopf chiral auxiliaries, which are used in asymmetric synthesis of -amino acids. In this article, we briefly discuss the chemistry of both heterocyclic compounds.","2,5-Diketopiperazines have attracted much attention because of their biological activities and molecular structure characteristics. Bis-lactim ethers derived from these 2,5-diketopiperazines include well-known organic molecules such as Schöllkopf chiral auxiliaries, which are used in asymmetric synthesis of -amino acids. In this article, we briefly discuss the chemistry of both heterocyclic compounds.","null","null","2015-07","Heterocycles","Heterocycles","Vol.91","No.7","1349","1375","eng","null","true","introduction_scientific_journal","null","null","10.3987/REV-15-820","0385-5414","null","null","null","null","null"
"薬学研究への道:「舎短取長」と書かれた色紙","薬学研究への道:「舎短取長」と書かれた色紙","佐野 茂樹","Shigeki Sano","null","null","null","null","null","2012-01","薬奨ニュース","薬奨ニュース","Vol.14","null","9","9","jpn","null","null","introduction_scientific_journal","null","null","null","null","null","null","null","null","null"
"化学レビュー:多彩に機能するジケトピペラジン","化学レビュー:多彩に機能するジケトピペラジン","佐野 茂樹, 中尾 允泰","Shigeki Sano, Michiyasu Nakao","null","null","null","null","null","2012-01","化学","化学","Vol.67","No.2","48","52","jpn","null","null","introduction_scientific_journal","null","null","null","0451-1964","null","null","null","null","null"
"Principle and Clinical Usefulness of the Infrared Fluorescence Endoscopy","Principle and Clinical Usefulness of the Infrared Fluorescence Endoscopy","Susumu Ito, Naoki Muguruma, Tetsuo Kimura, Hiromi Yano, Yoshitaka Imoto, Koichi Okamoto, Masako Kaji, Shigeki Sano, Yoshimitsu Nagao","Susumu Ito, Naoki Muguruma, Tetsuo Kimura, Hiromi Yano, Yoshitaka Imoto, Koichi Okamoto, Masako Kaji, Shigeki Sano, Yoshimitsu Nagao","null","Since there is no infrared fluorescence materials in the living body, infrared fluorescence labeling materials are very useful for making a diagnosis of a micro cancer. We have developed an infrared fluorescence endoscope (IRFE) and indocyanin green (ICG)-derivative as infrared fluorescence labeling materials to evaluate gastrointestinal neoplastic lesions. The study aims were to apply an IRFE and to demonstrate its usefulness in detecting cancerous tissue using an antibody coupled with ICG-derivative. IRFE consisted of an infrared endoscope equipped with excitation (710-790 nm) and barrier (810-920 nm) filters and an intensified CCD camera. We have developed ICG N-hydroxy sulfo succinimide ester (ICG-sulfo-OSu) and 3-ICG-acyl-1, 3-thiazolidine-2-thione (ICG-ATT) as an infrared fluorescent-labeling reagent. ICG-derivative-labeled mouse anti-human carcinoembryonic antigen (CEA) antibody and MUC1 antibody were employed in this study. Moreover, we examined the ability of a reinforcement agent, octylglucoside, to intensity fluorescence from the labeled antibody. Biopsy specimens of gastric cancer were stained with anti-CEA antibody by the avidin-biotinylated peroxidase complex method. Among the positive specimens, freshly resected stomach from three cases were used for the infrared (IR) imaging analysis. The incubation of freshly resected stomach specimens with ICG-anti-CEA antibody-complex resulted in positive staining of the tumor sites by IRFE, and the IR fluorescent images correlated well with the tumor sites. The immunohistochemical studies suggested that the intensity of IR fluorescence of ICG-ATT-MUC1 was stronger than that of ICG-sulfo-OSu. In tumor sections, the reinforcement agent intensified fluorescence, ever at low antibody concentrations. Therefore, we conclude that an anti-CEA (and/or MUC1) antibody with affinity for cancerous lesions and labeled with ICG-derivative can be imaged with this IRFE. Specific antibodies tagged with ICG-derivative with the reinforcement agent can label cancer cells and generate a strong enough fluorescent signal to detect small cancers when examined with an IR fluorescence endoscope.","Since there is no infrared fluorescence materials in the living body, infrared fluorescence labeling materials are very useful for making a diagnosis of a micro cancer. We have developed an infrared fluorescence endoscope (IRFE) and indocyanin green (ICG)-derivative as infrared fluorescence labeling materials to evaluate gastrointestinal neoplastic lesions. The study aims were to apply an IRFE and to demonstrate its usefulness in detecting cancerous tissue using an antibody coupled with ICG-derivative. IRFE consisted of an infrared endoscope equipped with excitation (710-790 nm) and barrier (810-920 nm) filters and an intensified CCD camera. We have developed ICG N-hydroxy sulfo succinimide ester (ICG-sulfo-OSu) and 3-ICG-acyl-1, 3-thiazolidine-2-thione (ICG-ATT) as an infrared fluorescent-labeling reagent. ICG-derivative-labeled mouse anti-human carcinoembryonic antigen (CEA) antibody and MUC1 antibody were employed in this study. Moreover, we examined the ability of a reinforcement agent, octylglucoside, to intensity fluorescence from the labeled antibody. Biopsy specimens of gastric cancer were stained with anti-CEA antibody by the avidin-biotinylated peroxidase complex method. Among the positive specimens, freshly resected stomach from three cases were used for the infrared (IR) imaging analysis. The incubation of freshly resected stomach specimens with ICG-anti-CEA antibody-complex resulted in positive staining of the tumor sites by IRFE, and the IR fluorescent images correlated well with the tumor sites. The immunohistochemical studies suggested that the intensity of IR fluorescence of ICG-ATT-MUC1 was stronger than that of ICG-sulfo-OSu. In tumor sections, the reinforcement agent intensified fluorescence, ever at low antibody concentrations. Therefore, we conclude that an anti-CEA (and/or MUC1) antibody with affinity for cancerous lesions and labeled with ICG-derivative can be imaged with this IRFE. Specific antibodies tagged with ICG-derivative with the reinforcement agent can label cancer cells and generate a strong enough fluorescent signal to detect small cancers when examined with an IR fluorescence endoscope.","null","null","2006-02","The Journal of Medical Investigation : JMI","The Journal of Medical Investigation : JMI","Vol.53","No.1/2","1","8","eng","null","null","introduction_scientific_journal","null","null","10.2152/jmi.53.1","1343-1420","null","null","null","null","null"
"Cyclization, Ring Expansion, and Several Cascade Reactions Utilizing Allenylic Molecular Structure Characteristics","Cyclization, Ring Expansion, and Several Cascade Reactions Utilizing Allenylic Molecular Structure Characteristics","Yoshimitsu Nagao, Shigeki Sano","Yoshimitsu Nagao, Shigeki Sano","null","Various kinds of new reactions based on allenylic molecular structure characteristics have been described. Specifically, mild alkaline hydrolysis of diethyl α-acetylamino (or methoxy) -α-alkynylmalonates generates conjugated allenyl esters which promote 5-endo-mode heterocyclic cyclization giving trisubsutituted oxazoles, SH-enzyme inhibition, new chiral pyrrolinones (cathepsin B inhibitors) formation, and Myers-type biradical aromatization in a cascade reaction manner. Systematic ortho vicinal-endo-mode-, geminal spiro-endo-mode-, and meta ansa-endo-mode-cyclization reactions have been accomplished by using numerous conjugated allenyl ketones and Lewis acids. Base-mediated and palladium (0) -catalyzed cascade heterocyclic and carbocyclic ring-expansion reactions have been achieved by using hydroxy-substituted allenyl cyclic compounds.","Various kinds of new reactions based on allenylic molecular structure characteristics have been described. Specifically, mild alkaline hydrolysis of diethyl α-acetylamino (or methoxy) -α-alkynylmalonates generates conjugated allenyl esters which promote 5-endo-mode heterocyclic cyclization giving trisubsutituted oxazoles, SH-enzyme inhibition, new chiral pyrrolinones (cathepsin B inhibitors) formation, and Myers-type biradical aromatization in a cascade reaction manner. Systematic ortho vicinal-endo-mode-, geminal spiro-endo-mode-, and meta ansa-endo-mode-cyclization reactions have been accomplished by using numerous conjugated allenyl ketones and Lewis acids. Base-mediated and palladium (0) -catalyzed cascade heterocyclic and carbocyclic ring-expansion reactions have been achieved by using hydroxy-substituted allenyl cyclic compounds.","null","null","2003-11-01","Journal of Synthetic Organic Chemistry, Japan","Journal of Synthetic Organic Chemistry, Japan","Vol.61","No.11","1088","1098","eng","null","null","introduction_scientific_journal","null","null","10.5059/yukigoseikyokaishi.61.1088","0037-9980","null","http://ci.nii.ac.jp/naid/10011908536/","null","null","null"
"赤外線蛍光内視鏡の原理と応用","赤外線蛍光内視鏡の原理と応用","伊東 進, 六車 直樹, 林 重仁, 日下 至弘, 多田津 昌也, 多田津 陽子, 岡本 耕一, 井本 佳孝, 稲山 久美, 板東 輝実, 田岡 聡子, 高川 真由子, 矢野 充保, 伊井 邦雄, 長尾 善光, 佐野 茂樹, 芝村 誠一, 島田 典招, 石田 和彦, 中村 一成","Susumu Ito, Naoki Muguruma, 林 重仁, 日下 至弘, 多田津 昌也, 多田津 陽子, Koichi Okamoto, 井本 佳孝, 稲山 久美, 板東 輝実, 田岡 聡子, 高川 真由子, 矢野 充保, 伊井 邦雄, Yoshimitsu Nagao, Shigeki Sano, 芝村 誠一, 島田 典招, 石田 和彦, 中村 一成","null","null","null","null","null","2003","Biomedical THERMOLOGY","Biomedical THERMOLOGY","Vol.23","null","77","97","null","null","null","introduction_scientific_journal","null","null","null","null","null","null","null","null","null"
"エナンチオ分岐的反応","エナンチオ分岐的反応","佐野 茂樹","Shigeki Sano","null","null","null","null","null","2000","有機合成化学協会誌","Journal of Synthetic Organic Chemistry, Japan","Vol.58","No.8","795","795","jpn","null","null","introduction_scientific_journal","null","null","null","null","null","null","null","null","null"
"ヘテロ原子の特性を活用する高立体選択的反応の開発ーHWE反応の新展開ー","Development of Highly Stereoselective Reactions Utilizing Heteroatoms New Approach to the Stereoselective Horner-Wadsworth-Emmons Reaction","佐野 茂樹","Shigeki Sano","null","null","null","null","null","2000","薬学雑誌","Journal of the Pharmaceutical Society of Japan","Vol.120","No.5","432","444","jpn","null","null","introduction_scientific_journal","null","null","null","0031-6903","null","null","null","null","null"
"ヘテロ原子の特性を活用する高立体選択的反応の開発ーα置換セリン誘導体の不斉合成ー","Development of Highly Stereoselective Reactions Utilizing Heteroatoms Asymmetric Synthesis of α-Substituted Serines","佐野 茂樹","Shigeki Sano","null","null","null","null","null","2000","薬学雑誌","Journal of the Pharmaceutical Society of Japan","Vol.120","No.1","28","41","jpn","null","null","introduction_scientific_journal","null","null","null","0031-6903","null","null","null","null","null"
"α-置換セリン誘導体の不斉合成","Asymmetric Synthesis of a-Substituted Serines","佐野 茂樹, 長尾 善光","Shigeki Sano, Yoshimitsu Nagao","null","null","null","null","null","2000","有機合成化学協会誌","Journal of Synthetic Organic Chemistry, Japan","Vol.58","No.8","756","765","jpn","null","null","introduction_scientific_journal","null","null","null","null","null","null","null","null","null"
"トピックス:〈有機化学〉新しいホスト分子の開発ーリン酸エステルの認識ー","トピックス:〈有機化学〉新しいホスト分子の開発ーリン酸エステルの認識ー","佐野 茂樹","Shigeki Sano","null","null","null","null","null","1992","ファルマシア","Farumashia","Vol.28","No.9","991","991","jpn","null","null","introduction_scientific_journal","null","null","null","0014-8601","null","null","null","null","null"
"トピックス:〈有機化学〉新しい不斉制御システムを活用する高エナンチオ選択的炭素ー炭素結合反応","トピックス:〈有機化学〉新しい不斉制御システムを活用する高エナンチオ選択的炭素ー炭素結合反応","佐野 茂樹","Shigeki Sano","null","null","null","null","null","1990","ファルマシア","Farumashia","Vol.26","No.4","356","356","jpn","null","null","introduction_scientific_journal","null","null","null","0014-8601","null","null","null","null","null"
"光学活性ホスホノ酢酸エステル及び類縁体の合成開発と不斉HWE反応への応用研究","Synthesis of Novel Phosphonoacetates Bearing a Stereogenic Phosphorus Atom and Application to Asymmetric Horner-Wadsworth-Emmons Reaction","佐野 茂樹","Shigeki Sano","null","null","null","null","null","2008","薬学研究の進歩 研究成果報告集 24","Advances in Pharmaceutical Sciences, The Ressearch Foundation for Pharmaceutical Sciences 24","null","null","37","43","jpn","null","null","others","null","null","null","null","null","null","null","null","null"
"研究助成金・奨励金贈呈者公表文献一覧表(2000年∼2005年) --- キラル-アキラル配位子組合せ系を基盤とする触媒的不斉反応場の構築","研究助成金・奨励金贈呈者公表文献一覧表(2000年∼2005年) --- キラル-アキラル配位子組合せ系を基盤とする触媒的不斉反応場の構築","佐野 茂樹","Shigeki Sano","null","null","null","null","null","2007-11","財団法人 武田科学振興財団","財団法人 武田科学振興財団","null","null","null","null","jpn","null","null","others","null","null","null","null","null","null","null","null","null"
"平成16年度∼平成18年度科学研究費補助金(基盤研究(B))研究成果報告書 --- シラアレンカチオン活性種及び類縁体の合成開発と応用研究","平成16年度∼平成18年度科学研究費補助金(基盤研究(B))研究成果報告書 --- シラアレンカチオン活性種及び類縁体の合成開発と応用研究","長尾 善光, 佐野 茂樹","Yoshimitsu Nagao, Shigeki Sano","null","null","null","null","null","2007-05","null","null","null","null","null","null","jpn","null","null","others","null","null","null","null","null","null","null","null","null"
"平成17年度∼平成18年度科学研究費補助金(基盤研究(C)研究成果報告書 --- P-キラルホスホノ酢酸エステル及び類縁体の合成開発と不斉HWE反応への応用","平成17年度∼平成18年度科学研究費補助金(基盤研究(C)研究成果報告書 --- P-キラルホスホノ酢酸エステル及び類縁体の合成開発と不斉HWE反応への応用","佐野 茂樹","Shigeki Sano","null","null","null","null","null","2007-05","null","null","null","null","null","null","jpn","null","null","others","null","null","null","null","null","null","null","null","null"
"平成15年度∼平成16年度科学研究費補助金(基盤研究(C)(2))研究成果報告書 --- 高立体選択的フルオロオレフィンアミドイソステア合成法の開発研究","平成15年度∼平成16年度科学研究費補助金(基盤研究(C)(2))研究成果報告書 --- 高立体選択的フルオロオレフィンアミドイソステア合成法の開発研究","佐野 茂樹","Shigeki Sano","null","null","null","null","null","2005-03","null","null","null","null","null","null","jpn","null","null","others","null","null","null","null","null","null","null","null","null"
"平成14年度∼平成15年度科学研究費補助金(基盤研究(B)(2))研究成果報告書 --- 新規チアゾール関連化合物の分子設計及び合成と多目的機能開発への応用","平成14年度∼平成15年度科学研究費補助金(基盤研究(B)(2))研究成果報告書 --- 新規チアゾール関連化合物の分子設計及び合成と多目的機能開発への応用","長尾 善光, 佐野 茂樹","Yoshimitsu Nagao, Shigeki Sano","null","null","null","null","null","2004-05","null","null","null","null","null","null","jpn","null","null","others","null","null","null","null","null","null","null","null","null"
"徳島大学先端医療開発研究センター設置準備室成果報告書","徳島大学先端医療開発研究センター設置準備室成果報告書","渋谷 雅之, 木戸 博, 林 良夫, 根本 尚夫, 佐野 茂樹, 安友 康二, 東 博之, 西岡 安彦, 寺尾 純二, 二川 健, 三澤 弘明, 松尾 繁樹, 馬場 嘉信, 松本 耕三, 三好 弘一, 曽根 三郎","Masayuki Shibuya, Hiroshi Kido, Yoshio Hayashi, Hisao Nemoto, Shigeki Sano, Koji Yasutomo, Hiroyuki Azuma, Yasuhiko Nishioka, Junji Terao, Takeshi Nikawa, Hiroaki Misawa, Shigeki Matsuo, Yoshinobu Baba, Kozo Matsumoto, Hirokazu Miyoshi, Saburo Sone","null","null","null","null","null","2002-12","null","null","null","null","null","null","jpn","null","null","others","null","null","null","null","null","null","null","null","null"
"平成12年度∼平成13年度科学研究費補助金(基盤研究(B)(2))研究成果報告書 --- 非結合性相互作用を機軸とする新反応メディアの構築とその応用研究","平成12年度∼平成13年度科学研究費補助金(基盤研究(B)(2))研究成果報告書 --- 非結合性相互作用を機軸とする新反応メディアの構築とその応用研究","長尾 善光, 佐野 茂樹","Yoshimitsu Nagao, Shigeki Sano","null","null","null","null","null","2002-03","null","null","null","null","null","null","jpn","null","null","others","null","null","null","null","null","null","null","null","null"
"平成11年度∼平成12年度科学研究費補助金(基盤研究(C)(2))研究成果報告書 --- ルイス酸を活用する新しい高立体選択的HWE反応の開発研究","平成11年度∼平成12年度科学研究費補助金(基盤研究(C)(2))研究成果報告書 --- ルイス酸を活用する新しい高立体選択的HWE反応の開発研究","佐野 茂樹","Shigeki Sano","null","null","null","null","null","2001-03","null","null","null","null","null","null","jpn","null","null","others","null","null","null","null","null","null","null","null","null"
"平成10年度∼平成11年度科学研究費補助金(基盤研究(B)(2))研究成果報告書 --- カテプシン類阻害剤の分子設計ならびに合成開発","平成10年度∼平成11年度科学研究費補助金(基盤研究(B)(2))研究成果報告書 --- カテプシン類阻害剤の分子設計ならびに合成開発","長尾 善光, 佐野 茂樹","Yoshimitsu Nagao, Shigeki Sano","null","null","null","null","null","2000-03","null","null","null","null","null","null","jpn","null","null","others","null","null","null","null","null","null","null","null","null"
"平成8年度∼平成9年度科学研究費補助金(基盤研究(B)(2))研究成果報告書 --- 医薬品創製を指向する新反応モードの開発研究","平成8年度∼平成9年度科学研究費補助金(基盤研究(B)(2))研究成果報告書 --- 医薬品創製を指向する新反応モードの開発研究","長尾 善光, 佐野 茂樹","Yoshimitsu Nagao, Shigeki Sano","null","null","null","null","null","1998-03","null","null","null","null","null","null","jpn","null","null","others","null","null","null","null","null","null","null","null","null"