Coronary flow velocity immediately after primary coronary stenting as a predictor of ventricular wall motion recovery in acute myocardial infarction

The purpose of this study was to examine the relationship between the pattern of coronary blood flow velocity immediately after successful primary stenting and the recovery of left ventricular (LV) wall motion in patients with acute myocardial infarction (AMI). It is difficult to predict the recovery of LV wall motion immediately after direct angioplasty in AMI. Recent reports indicate that dysfunctional coronary microcirculation is an important determinant of prognosis for AMI patients after successful reperfusion. We measured left anterior descending coronary flow velocity variables using a Doppler guide wire immediately after successful primary stenting in 31 patients with their first anterior AMI. The patients were divided into two groups: those with and those without early systolic reverse flow (ESRF). Changes in LV regional wall motion (RWM) and ejection fraction (EF) at admission and at discharge were compared between the two groups. Coronary flow velocity variables immediately after primary stenting were compared with changes in left ventriculographic indexes. The change in RWM was significantly greater in the non-ESRF group than it was in the ESRF group (0.9 +/- 0.7 vs. -0.1 +/- 0.3 standard deviation/chord, respectively, p < 0.001). The change in EF was also significantly greater in the non-ESRF group than it was in the ESRF group (10 +/- 10 vs. 1 +/- 6%, respectively, p < 0.05). In the non-ESRF group (diastolic to systolic velocity ratio [DSVR] <3.0), the DSVR correlated positively with the change in RWM (r = 0.60, p < 0.005, n = 24) and the change in EF (r = 0.52, p < 0.01). The coronary flow velocity pattern measured immediately after successful primary stenting is predictive of the recovery of regional and global LV function in patients with AMI.

Journal of the American College of Cardiology


Patient with atrioventricular node reentrant tachycardia with eccentric retrograde left-sided activation Treatment with radio-frequency catheter ablation

We describe a patient with supraventricular tachycardia with triple atrioventricular (AV) node pathway physiology. A discontinuous curve was present in the antegrade AV nodal function curves. During right ventricular pacing, the earliest retrograde atrial activation was recorded at the left-sided coronary sinus electrode. The retrograde ventricular-atrial interval was long and had decremental conduction. We induced a slow-slow AV node reentrant tachycardia (AVNRT) with eccentric retrograde left-sided activation. After slow pathway ablation, dual AV nodal pathway physiology was present. AVNRT with eccentric retrograde left-sided activation is relatively rare, and our findings suggest that eccentric retrograde left-sided atrial inputs consist partially of a slow pathway and disappear with slow pathway ablation.


Detection of left ventricular regional relaxation abnormalities and asynchrony in patients with hypertrophic cardiomyopathy with the use of tissue Doppler imaging.

It is well known that the distribution and magnitude of left ventricular (LV) hypertrophy are not uniform in patients with hypertrophic cardiomyopathy (HCM), which results in regional heterogeneity of LV early diastolic function. The advent of tissue Doppler imaging (TDI) has allowed the noninvasive evaluation of regional LV wall motion velocities. The aim of this study was to evaluate regional LV relaxation abnormalities and asynchrony noninvasively in patients with HCM by using pulsed and color-coded TDI. We studied 20 patients with asymmetric septal hypertrophy (HCM group) and 18 age-matched normal patients (control group). The peak early diastolic motion velocity (Ew) and time from the aortic component of the second heart sound to the peak of the Ew (II(A)-Ew) were measured by pulsed TDI. The myocardial velocity gradient during early diastole (MVG-Ew) also was measured by color-coded TDI. Mean values for these parameters were determined on the basis of measurements made at 2 sites of the ventricular septum or posterior wall at the levels of chordae tendineae and papillary muscles. The mean Ew and mean MVG-Ew for the ventricular septum and posterior wall were significantly lower, and mean II(A)-Ew was significantly prolonged in the HCM group compared with the control group. This difference was most pronounced in the hypertrophied ventricular septum of the HCM group. The standard deviations of II(A)-Ew for the ventricular septum and posterior wall were significantly greater in the HCM group than in the control group. The time constant of LV pressure decay during isovolumic diastole (tau) correlated inversely with Ew and MVG-Ew and correlated directly with II(A)-Ew. Furthermore, tau correlated directly with the standard deviation of the II(A)-Ew. LV early diastolic function in patients with HCM may be mediated by an augmentation of regional LV relaxation abnormalities and asynchrony.


Circulating adhesion molecules and severity of coronary atherosclerosis

Circulating leukocytes are recruited at atherosclerotic sites through a family of adhesion molecules. Circulating forms of adhesion molecules in peripheral blood can be quantified now. To evaluate the relationship between circulating adhesion molecules and severity of coronary atherosclerosis. Subjects included 81 patients undergoing diagnostic coronary angiography, 12 of whom had normal coronary arteries (control group). The remaining 69 patients with demonstrable coronary atherosclerosis were divided into two groups by use of Gensini scores, namely mild atherosclerosis (n = 36, Gensini score 1-20) and severe atherosclerosis (n = 33, Gensini score > 20). Serum levels of circulating intercellular adhesion molecule-1 (ICAM-1), vascular cellular adhesion molecule-1 (VCAM-1), and E-selectin of groups measured before angiography were compared. Circulating levels of ICAM-1 in members of mild and severe atherosclerosis groups were significantly higher than those in members of the control group, whereas there was no significant difference among circulating levels of VCAM-1 in members of the three groups. Circulating levels of E-selectin in members of the mild atherosclerosis group were significantly higher than those in members of the severe atherosclerosis and control groups. These findings suggest that E-selectin is related to the early stage, and ICAM-1 is related to the advanced stage, of coronary atherosclerosis. With progression of atherosclerosis, one-step adhesion by ICAM-1 could become more important than multistep adhesion involving E-selectin, ICAM-1, and VCAM-1. These molecules may serve as markers for severity of coronary atherosclerosis.


冠動脈攣縮性狭心症による胸痛を来たした無脾症候群の1例

冠動脈攣縮性狭心症による胸痛を来たした無脾症候群の1例


Evaluation of left ventricular contraction abnormalities in patients with dilated cardiomyopathy with the use of pulsed tissue doppler imaging

Journal of the American Society of Echocardiography


Coronary flow velocity immediately after reperfusion reflects myocardial microcirculation in canine models of acute myocardial infarction.

Recent reports indicate that the coronary microcirculation is sometimes injured, despite successful reperfusion in acute myocardial infarction (AMI). However, it is difficult to evaluate the coronary microcirculation immediately after reperfusion by using only angiography. The purpose of this study was to examine the relationship between the pattern of coronary blood flow velocity and myocardial microcirculatory injury immediately after reperfusion in AMI. The authors recorded the left circumflex coronary flow velocity by using the Doppler guide wire method 10 minutes after reperfusion in a canine model of AMI. In addition, myocardial contrast echocardiography was performed with the injection of contrast medium into the left circumflex coronary artery before clamping of the coronary artery and 15 minutes after release of the clamp. From these images, the ratio of the normalized gray-level postreperfusion to preclamping in the contrast-enhanced area was determined. It was compared with coronary flow velocity variables. In the 10 dogs with a diastolic-to-systolic velocity ratio (DSVR) < 4.0, this velocity ratio 10 minutes after reperfusion correlated positively (r = 0.75, p < 0.01) with the normalized gray-level ratio. However, the remaining three dogs with a DSVR > or = 4.0 markedly deviated from this pattern. Coronary flow velocities in the three dogs were characterized by a greater decrease in systolic flow velocity and occurrence of early systolic retrograde flow. Myocardial contrast echocardiographic images in these three dogs demonstrated a lower normalized gray-level ratio. In conclusion, the coronary flow velocity pattern immediately after reperfusion may reflect myocardial microcirculatory injury.


Influence of aging on systolic left ventricular wall motion velocities along the long and short axes in clinically normal patients determined by pulsed tissue Doppler imaging.


Effect of aging on diastolic left ventricular myocardial velocities measured by pulsed tissue Doppler imaging in healthy subjects.


Effect of an acute increase in afterload on left ventricular regional wall motion velocity in healthy subjects.


Pulsed tissue Doppler imaging of left ventricular systolic and diastolic motion velocities to evaluate differences between long and short axes in healthy subjects.


Left ventricular systolic wall motion velocities along the long and short axis measured by pulsed tissue Doppler imaging in patients with atrial fibrillation.


Echocardiographic detection of occult cor pulmonale during exercise in patients with chronic obstructive pulmonary disease


Evaluation of the hemodynamic relationship between the left atrium and left ventricle during atrial systole by pulsed tissue Doppler imaging in patients with left heart failure.


Assessment of the systolic left ventricular myocardial velocity profile and gradient using tissue Doppler imaging in patients with hypertrophic cardiomyopathy.


Coronary flow velocity immediately after reperfusion reflects myocardial microcirculation in canine models of acute myocardial infarction


Left ventricular diastolic properties of hypertensive patients measured by pulsed tissue Doppler imaging.


Assessment of abnormal left atrial relaxation by transesophageal pulsed Doppler echocardiography of pulmonary venous flow velocity.


The pattern of alteration in flow velocity in the recanalized artery is related to left ventricular recovery in patients with acute infarction and successful direct balloon angioplasty

We evaluated the relationship between alterations in coronary flow velocity during the acute phase of acute myocardial infarction (AMI) and the recovery of left ventricular wall motion in patients who underwent successful primary angioplasty. The status of the coronary microcirculation is the major determinant of the prognosis of patients who have had successful reperfusion after AMI. Animal studies have shown that dynamic changes in regional flow are associated with the extent of infarction. Evaluation of alterations in coronary flow velocity in infarcted arteries may provide information about microcirculatory damage. Flow velocity of the distal anterior descending artery was continuously monitored with the use of a Doppler guide wire immediately after recanalization for 18 +/- 4 h in 19 patients who underwent successful primary angioplasty after anterior AMI. Subjects were divided into two groups on the basis of the time course of alterations in average peak velocity (APV). Group D consisted of patients who had progressive decreases in APV through the next day (n = 9), and Group I comprised patients with an increase in APV after a transient decline (n = 10). Ejection fraction (EF) and regional wall motion (RWM) were assessed by left ventriculography performed on admission and at discharge. The APV at the end of monitoring was greater in group I than in group D. In group I, EF and RWM were significantly improved at discharge. The change in EF was greater in group I than in group D (17 +/- 9% vs. 4 +/- 9%, p = 0.007), as was the change in RWM (0.96 +/- 0.23 vs. 0.13 +/- 0.36 SD/chord, p < 0.0001). The alteration in flow velocity in recanalized infarcted arteries is related to left ventricular recovery. A progressive decrease in velocity after angioplasty implies no reflow, which is associated with a poor recovery of left ventricular function. Reperfusion injury may account in part for this phenomenon.

Journal of the American College of Cardiology


The Effects of Nicorandil on Electrophysiological Changes in Acute Myocardial Ischemia and Reperfusion


Evaluation of left atrial filling using systolic pulmonary venous flow velocity measurements in patients with atrial fibrillation.


Right and left ventricular wall motion velocities as diagnostic indicators of constrictive pericarditis.


Right atrial potential profiles during atrial fibrillation predict the success of atrial defibrillation

The right atrial electric potential was measured in 29 patients with chronic atrial fibrillation, and the clinical utility of these measurements in predicting the success of atrial defibrillation was investigated. The endocardial electric potential was recorded at 12 sites within the right atrium (high, middle, and low loci of anterior, posterior, lateral, and medial sites of the right atrium) with an electrode catheter. The duration and polar displacement of the atrial waves were measured at the one site that showed the maximum atrial electric potential among the 12 sites. The ratio of the maximum to the minimum atrial electric potential (atrial wave ratio) was calculated. Patients were classified into two groups according to the success (n = 6) or failure (n = 23) of atrial defibrillation. Electrophysiologic data were compared between the two groups, and correlations were evaluated between the data and the maximal left atrial diameter obtained from M-mode echocardiography. The two groups did not differ in the duration and polar displacement of the atrial waves. However, the atrial wave ratio was significantly lower in the success group than in the failure group, and the success rate of atrial defibrillation was also significantly greater in the patients with an atrial wave ratio of 10 or lower. This ratio showed a positive correlation with the maximal left atrial diameter; it became more difficult to achieve atrial defibrillation as the atrial wave ratio increased. Thus, the right atrial electric potential profile of patients with atrial fibrillation is a useful predictor of the success of atrial defibrillation.


Characteristics of Coronary Flow Velocity in Constrictive Pericarditis

Catheterization and Cardiovascular Diagnosis


Electrophysiologic effects of quinaprilat in dogs during acute myocardial ischemia and following reperfusion.

There have been few studies concerning the electrophysiologic changes associated with the use of angiotensin-converting enzyme inhibitors in patients with acute myocardial infarction. We examined the electrophysiologic effects of quinaprilat in dogs during acute myocardial ischemia and following reperfusion. The left anterior descending coronary artery was occluded for 10 min and reperfused for 10 min. Animals received intravenous quinaprilat (3 micrograms/kg per min, quinaprilat group) or saline (control group). We measured the ventricular effective refractory period and intra-myocardial conduction time within the left anterior descending coronary artery region (ischemic region) during myocardial ischemia and following reperfusion, and determined the frequency of ventricular fibrillation. The effective refractory period in the ischemic region decreased during myocardial ischemia and decreased further immediately after reperfusion in the control group. The intra-myocardial conduction time in the ischemic region increased during myocardial ischemia but rapidly shortened after reperfusion in the control group. In the quinaprilat group, however, no significant differences were evident between the ischemic and non-ischemic regions in either the effective refractory period or the intra-myocardial conduction time during myocardial ischemia or following reperfusion. The percentage shortening of the effective refractory period and the percentage prolongation of the intra-myocardial conduction time in the ischemic region were significantly lower in the quinaprilat group than in the control group during myocardial ischemia and following reperfusion. The frequency of ventricular fibrillation during myocardial ischemia and following reperfusion was significantly lower in the quinaprilat group (21%) than in the control group (74%; P < 0.01). Quinaprilat protects against electrophysiologic abnormalities, and may decrease arrhythmias during acute myocardial ischemia and following reperfusion.


Characteristics of coronary flow velocity in constrictive pericarditis


Coronary flow velocity patterns immediately after reperfusion reflect pathologic characteristics of reperfused myocardium in canine models of acute myocardial infarction

It is difficult to evaluate the extent of myocardial injury after successful reperfusion following acute myocardial infarction (AMI). We investigated the relationship between the coronary flow velocity pattern immediately after reperfusion and pathologic characteristics after myocardial reperfusion injury in dogs. We measured distal coronary flow velocity variables in the left circumflex coronary artery in a canine model of AMI (n = 12) 10 min after the release of a clamp (3-10 h clamp procedure) using a 0.35 mm Doppler guide-wire. Dogs were divided into two groups according to presence or absence of early systolic retrograde coronary flow. Hearts were excised 2 h after reperfusion and examined histopathologically. The clamping time tended to be longer in dogs with early systolic retrograde coronary flow. Neutrophil infiltration was observed in the myocardium of dogs without systolic retrograde flow (n = 9); hemorrhage was rarely detectable and the myocardium maintained a bundle form. However, the bundle form of the myocardium became rough, and the severity of the incidence of hemorrhage tended to increase as the ratio of the diastolic coronary flow velocity to systolic velocity (DSVR) decreased. Vacuolar degeneration of the myocardium was also observed in hearts with a relatively low DSVR. In the group with systolic retrograde flow (n = 3), hearts were characterized by coagulation necrosis, marked vacuolar degeneration of the myocardium and diffusely distributed red cells in the intermyocytes. Systolic antegrade flow velocity was much reduced in this group, resulting in a markedly increased DSVR. These findings appeared to be related to severe myocardial damage. Coronary flow velocity patterns immediately after successful reperfusion appear to reflect the pathologic characteristics of the reperfused myocardium in dogs with AMI.


Clinical application of pulsed Doppler tissue imaging for assessing abnormal left ventricular relaxation.


単冠動脈症を合併した肥大型心筋症の1例

単冠動脈症を合併した肥大型心筋症の1例


Safety and feasibility of continuous monitoring of coronary flow velocity in acute myocardial infarction by Doppler guide wire


Distal coronary flow velocity immediately after direct angioplasty for acute myocardial infarction


Efficacy of coronary angioplasty with a cutting balloon in a case of repeated coronary stenosis

The Tokushima Journal of Experimental Medicine


Noninvasive localization of accessory pathways by magnetocardiographic imaging

The magnetocardiogram (MCG) is a newly developed method that helps localize a cardiac current source. To test the clinical accuracy of a 7-channel biomagnetic system in the localization of early ventricular depolarization sites, the MCGs of 14 patients with Wolff-Parkinson-White (WPW) syndrome were recorded in a radiofrequency-shielded room. The locations of early ventricular depolarization sites were classified by standard 12-lead electrocardiograms (ECGs) and body surface isopotential mapping. The accessory pathways of 3 patients with WPW syndrome were located in the right free wall and in 11 patients in the left free wall. The three-dimensional (3-D) dipole location was computed every 2 ms from the onset of the QRS complex by the least-square method. These 3-D dipole locations were projected onto a gated magnetic resonance image in order to visualize the propagation of the calculated ventricular source. The results were compared with those obtained by body surface isopotential mapping, and electrocardiographic and electrophysiologic studies. The location of the deduced current dipole at 20 ms correlated well with the location of the accessory pathway by the body surface mappings in 12 of the 14 patients with WPW syndrome. The MCG is capable of precisely determining the 3-D location of a current source in a noninvasive manner and may be of potential benefit in the treatment of WPW syndrome by catheter ablation.


Effects of vesnarinone (OPC-8212) on Ca(2+)-activated K channels and cytosolic Ca2+ in cultured smooth muscle cells from porcine coronary artery.

Vesnarinone is a new, non vasodilating cardiotonic agent. This study compared the effects of vesnarinone and amrinone, a phosphodiesterase (PDE) inhibitors with vasodilating actions, on cultured smooth muscle cells from the porcine coronary artery. Application of vesnarinone (10(-4) M) or amrinone (10(-4) M) to the bath solution in cell-attached patches activated the KCa channel having a conductance of 133 pS (bath 2.7 mM K, pipette 140 mM K). Application of vesnarinone to the cytosolic side had no direct effect on KCa channel activities in inside-out patches. Activation of the KCa channel was suppressed when the intracellular production of cAMP was suppressed by preincubation with carbachol (10(-6) M). Amrinone, but not vesnarinone, lowered [Ca2+]i in the K(+)-depolarized smooth muscle cells (K+ = 70 mM). These results suggest that vesnarinone exerts an additional effect on [Ca2+]i that is independent of PDE inhibition. The difference in the effects on [Ca2+]i in vascular smooth muscle cells may explain in part the differing actions of these agents on vascular relaxation.


Effects of Vesnarinone(OPC-8212)on Ca2+-Activated K Channels and Cytosolic Ca2+- in Cultured Smooth Muscle Cells from Porcine Coronary Artery


Prediction of the site of origin of ventricular premature beat by magnetocardiogram

心臓磁界測定による心室性期外収縮の心室最早期興奮部位の推定

心磁図による診断法を確立するために，生体内の電流源を三次元的に推定する心磁図法と，心電図同期MRI断層法を併用して，心室性期外収縮発生源の位置を推定した．推定された値は，体表面電位図法から推定される発生源とほぼ一致し，診断学的にも有用であることがわかった．


マラソン前後における血中遊離型および硫酸抱合型カテコラミンの変動

マラソン前後における血中遊離型および硫酸抱合型カテコラミンの変動


7チャンネルSQUID磁束計による心臓磁界計測およびdipoleの位置推定

7チャンネルSQUID磁束計による心臓磁界計測およびdipoleの位置推定


Single moving dipole obtained from magnetic field of the heart in patients with left ventricular hypertrophy

Magnetocardiograms (MCGs) were recorded by means of a second-derivative SQUID (superconducting quantum interference device) magnetometer in 20 normal subjects and 28 patients with left ventricular overload to analyze the activation sequence of the heart and amplitude of estimated current source. In the normal subjects, the dipole was directed to the left and gradually superiorly 40 ms after the beginning of the QRS wave mainly due to the activation of the left ventricle. In the patients with hypertension, the direction and location of the dipoles were similar to those of the normal subjects, but their dipole moments were increased. In the patients with mitral regurgitation, the dipoles of late QRS were directed more inferiorly than in the normal subjects and their amplitude was increased. In the patients with aortic valve disease, the amplitude of the dipoles was increased markedly and their location was deviated more to the left than the dipoles of the normal subjects. We established the criterion for diagnosis of LVO from the dipole moment of 50 ms of 3.13 x 10(-3) A or more. The sensitivity of this criterion is significantly higher in the diagnosis of left ventricular overload than the electrocardiogram (ECG). The present study shows that the moving dipole method is useful to determine the increased electromotive force in patients with left ventricular overload and that sensitivity in diagnosis of left ventricular overload is increased.

Single moving dipole法により，高血圧，僧帽弁閉鎖不全，大動脈弁狭窄の症例について，推定dipoleの値を経時的定量的に求めた．健常例との比較により診断率の精度を比較検討し，各疾患の特徴と診断基準を明らかにした．


Vasopressin modulates K(+)-channel activities of cultured smooth muscle cells from porcine coronary artery

American Journal of Physiology, Heart and Circulatory Physiology


Endothelin blocks ATP-sensitive K+ channels and depolarizes smooth muscle cells of porcine coronary artery


正常例の初期QRS波のdipoleの位置推定‐心電図同期MRI画像上への表示‐

正常例の初期QRS波のdipoleの位置推定‐心電図同期MRI画像上への表示‐

The Journal of Japan Biomagnetism and Bioelectromagnetics Society


心磁図法による心室最早期興奮部位の推定‐磁界分布図と体表面電位図·心表面マッピングとの対比‐


Effects of vasopressin on ATP-sensitive and Ca2+-activated K+ channels of coronary arterial smooth muscle cells


Effects of vasopressin on K+ channels of vascular smooth muscle cells


冠動脈平滑筋細胞におけるEndothelinの作用

冠動脈平滑筋細胞におけるEndothelinの作用


Effects of nitroglycerin on ATP-induced Ca(++)-mobilization, Ca(++)-activated K channels and contraction of cultured smooth muscle cells of porcine coronary artery

The Journal of Pharmacology and Experimental Therapeutics


Alteration of Strength-Interval Relation by Class I Antiarrhythmic Drugs in Normal and K-Depolarized Cardiac Muscle Fibers

Jpn J Appl Physiol(Japanese journal of applied physiology)


Critical Limb Threatening Ischemia Due to Severe Polyarteritis Nodosa-A Case Report


Spontaneous thrombosis of a giant aneurysm complicated with the coronary-to-pulmonary artery fistula: a case report


Elevated Concentration of Interferon-Inducible Protein of 10kd (IP-10) is Associated with Coronary Atherosclerosis.


Predictors of Local Hypercoagulability after Sirolimus-Eluting Stent Implantation: Implication for Correlates of Late Stent Thrombosis.


Elevated Concentration of Pentraxin 3 is Associated with Coronary Plaque Vulnerability.


Ghrelin Attenuates Myocardial Ischemia/Reperfusion Injury via the Extracellular Signal-Regulated Kinase 1/2 and Phosphatidylinositol.


Long-Term Local Inflammatory Response after Coronary Artery Stenting with Drug-Eluting Stent.


Left Atrial Volume does not reflect Brain Natriuretic Peptide Levels in Patients with Atrial Fibrillation.


Importance of Left Atrial Function for the Pseudonormalization of Transmitral Flow Velocity Pattern in Patients with Hypertrophic Cardiomyopathy.


E/e' as a Predictor of the Cardiac Response to Increment of Preload in Patients with Atrial Fibrillation.


Long-term endothelial dysfunction after coronary artery stenting with drug-eluting stent associated with local inflammatory response.


Local hypercoagulability and endothelial dysfunction after sirolimus-eluting stent implantation: implication for late stent thrombosis.


Elevated concentration of Pentraxin 3 is associated with coronary plaque vulnerability.


Long-term local inflammatory response after coronary artery stenting with drug-eluting stent.


C-type natriuretic peptide ameliorates the progression of experimental autommune myocarditis.


Assessment of Left Atrial Ejection Force in Patients with Hypertensive Heart Disease.

Journal of the American Society of Echocardiography


Importance of Left Atrial Function in Cardiac Response to Increment of Preload in Patients with Old Myocardial Infarction: Assessment by Automated Left Atrial Volume Tracking Method.


Beat-To-Beat Variation of Mitral Annular Velocities in Atrial Fibrillation.


The Mitral L-Wave Predicts the Cardiac Response to Preload Increment in Atrial Fibrillation.


Usefulness of Tei Index in Atrial Fibrillation: Assessment by Dual Doppler Echocardiography.


Multicenter Trial for the Validation of Automated Function Imaging in Patients with Local Left Ventricular Asynergy (VANILLA Study).


Role of Left Atrial Function for Pseudonormalization of Transmitral Flow Velocity Pattern in Patients with Hypertrophic Cardiomyopathy.


Assessment of the cardiac response to increment of preload in patients with atrial fibrillation using dual pulsed Doppler echocardiography.


Measurement of left atrial volume curve by advanced 2D tissue tracking technique: validation by contrast multidetector computed tomography.


Relationship Between the Ratio of Peak Early Diastolic Transmitral Flow and Mitral Annular Velocities and the Plasma B-Type Natriuretic Peptide (BNP) Concentration in Patients with Atrial Fibrillation: Assessment by Simultaneous Recording of Transmitral Flow and Mitral Annular Velocity.

Journal of the American College of Cardiology


Effect of aging on left atrial myocardial strain evaluated by 2D tissue tracking during lower body positive pressure.


Differentiation of left atrial dysfunction by changes in transmitral flow velocities during lower body positive pressure.


Ghrelin Protects Myocardium Against Ischemia/Reperfusion Injury via Inhibiting Myocardial Apoptosis.


Longitudinal Myocardial Displacement and Strain Rate in the Hypertrophied Heart Evaluated by Tissue Strain Imaging With Doppler Angle Correction and Tissue Tracking Technique.


Temporal change in the left ventricular transmyocardial systolic velocity profile evaluated by color tissue Doppler imaging.


Noninvasive assessment of myocardial ischemia and necrosis using a newly developed tissue Doppler myocardial velocity profile.

Journal of the American Society of Echocardiography


Effect of angiotensin II receptor antagonist on left ventricular myocardial relaxation abnormality in hypertensive patients: evaluation using a newly developed myocardial velocity profile.


Quantitative analysis of the left ventricular segmental contractility in the normal subjects using newly developed angle-corrected tissue strain imaging.


Novel index for evaluating wall motion abnormality using newly developed angle-corrected tissue strain imaging.


Determinants of the left ventricular myocar-dial contractility in patients with hypertension evaluated by echocardiography.


Myocardial Characterization of Cardiac Amyloidosis Using Myocardial Velocity Profile: Comparison With Hypertensive Heart Disease.


Novel Strategy for Detecting Myocardial Viability by Evaluating Improvement of Early Diastolic Left Ventricular Asynchrony Using Dobutamine Stress Pulsed Tissue Doppler Imaging.


Prognostic value of atrial systolic mitral annulus motion velocity in patients with dilated failing heart.


Early Diastolic Transmural Myocardial Velocity Profile Evaluated by Tissue Doppler Imaging in Normal Subjects and Patients With Left Ventricular Hypertrophy.


Accurate Measurement of Systolic Transmural Myocardial Velocity Profile Using Tissue Doppler Imaging in Normal Subjects And Patients with Hypertrophic Cardiomyopathy.


The Role of Short And Long Axes Function for Determining Late Diastolic Left Ventricular Filling in Patients with Hypertension: Assessment by Pulsed Tissue Doppler Imaging.


Potential Application of Tissue Doppler Imaging of the Left Ventricular Myocardium in Assessing Regional Diastolic Function in Patients with Hypertrophic cardiomyopathy: Comparison with 1231-b-Methy1 Iodopheny1 Pentadecanoic Acid Myocardial Scintigraphy.


Ultrasonic myocardial characterization of cardiac amyloidosis using tissue Doppler imaging.


Quantitative assessment of left ventricular myocardial viability using systolic mitral annular descent velocity: A study with dobutamine stress pulsed tissue Doppler imaging.

Journal of the American College of Cardiology


Relationship between left atrial appendage function and plasma concentration of atrial natriuretic peptide.


Clinical application of pulsed Doppler tissue imaging for assessing abnormal relaxation of the left ventricle.


Assessment of myocardial circumferential shortening of the left ventricular wall using pulsed Doppler tissue imaging.


Non-invasive assessment of left ventricular relaxation by pulsed Doppler tissue imaging: comparison with cardiac catheterization.


Coronary flow velocity immediately after reperfusion reflects myocardial microcirculation in canine acute myocardial infarction models.


Preload Stress Echocardiography for the Assessment of Heart Failure With Preserved Ejection Fraction