ハイドロコロイド創傷被覆材(キズパワーパッドⓇ)による接触蕁麻疹症候群

ハイドロコロイド創傷被覆材(キズパワーパッドⓇ)による接触蕁麻疹症候群


A case of vitiligo that followed the path of a varicose vein in the lower leg.

Vitiligo is an acquired chronic depigmenting disorder of the skin and is characterized by the destruction of melanocytes. One of the clinical features of vitiligo is that damage to normal skin frequently results in the formation of depigmented macules, which is known as Köebner's phenomenon (KP). Here, we presented a case of vitiligo, in which depigmented macules followed the course of a dilated varicose vein. Dilatation of blood vessels was considered to contribute to the development of the vitiliginous lesions as a trigger for KP. Any kind of skin injury can trigger KP, but this is only the second case in which a dilated blood vessel caused KP in vitiligo. J. Med. Invest. 71 : 177-178, February, 2024.

The Journal of Medical Investigation : JMI


A case of intralymphatic histiocytosis mimicking lymphangioma circumscriptum associated with a puncture wound caused by a thorn

棘刺創部に生じ，限局性リンパ管腫様の臨床像を呈したintralymphatic histiocytosisの1例

Journal of the Japan Organization of Clinical Dermatologists


ヒト乳頭腫ウイルスが検出された肛囲のBowen病・Bowen癌の3例

ヒト乳頭腫ウイルスが検出された肛囲のBowen病・Bowen癌の3例

Japanese Journal of Clinical Dermatology


Podoplanin-positive cells located in the basal layer of Bowen disease include tumor cells with cancer stem cell properties.

Podoplanin (PDPN) is widely used as a marker of lymphatic endothelial cells. PDPN is also involved in tumor progression, and upregulated PDPN expression is often found in various cancers. In this study, we first immunohistochemically examined PDPN expression in 87 cases of Bowen disease. Positive expression was detected in 64.4% of Bowen disease specimens, and the positive cells were exclusively located in the basal layer and corresponded to palisaded basal cells (PBCs). PBCs have been considered to be residual normal keratinocytes so far, but PDPN expression in cancers is generally associated with poor clinical outcomes. We also examined PDPN expression in 27 cases of Bowen carcinoma. Diffuse and strong PDPN expression was detected in 22.2% of Bowen carcinoma specimens, and another 22.2% showed PDPN expression at the leading edges of tumor nests. These results prompted us to determine whether PDPN-positive cells are more tumorigenic than PDPN-negative cells. We cultured Bowen disease cells using a three-dimensional (3D) cell culture system and examined PDPN expression. In the cultured Bowen disease tissue, PDPN expression was again detected in the basal layer. Then, we isolated 1.2 × 10 PDPN-positive and -negative cells from the 3D organotypic culture of Bowen disease by fluorescence-activated cell sorting analysis and compared their tumorigenicity using 3D culture. The PDPN-positive tumor cells were able to regenerate Bowen disease tissue, but the PDPN-negative tumor cells were not. In addition, the regenerated Bowen disease tissue derived from the PDPN-positive cells exhibited PDPN expression in its basal layer, as the parental Bowen disease tissue did. These results indicate that PDPN-positive cells include tumor cells with cancer stem cell properties. Although the precise mechanism through which PDPN expression is involved in the pathogenesis of Bowen disease needs to be determined, PDPN may be a novel druggable target for Bowen disease.


透析患者における粉瘤発生についての検討

透析患者における粉瘤発生についての検討


JAK阻害薬投与中の関節リウマチ患者に発症し蜂窩織炎様の所見を呈した皮膚クリプトコッカス症の1例


A case of cutaneous collagenous vasculopathy


Repeated insulin injection without site rotation affects skin thickness - ultrasonographic and histological evaluation

The influence of repeated insulin injection on subcutaneous tissue is known, but its impact on the skin is unclear. Therefore, this study aimed to elucidate the impact of repeated insulin injections on the skin. The properties of the skin and the subcutaneous tissue were evaluated in 52 insulin-treated adult patients with diabetes with abnormal findings at the site of self-injection (36 with subcutaneous nodules, 16 with suspected subcutaneous tissue induration) by ultrasonography. In all subjects, both normal and abnormal areas were examined. In addition, skin biopsies were performed in four subjects. The skin thickness of the normal and abnormal skin sites was 1.95 (1.60, 2.50) and 2.80 (2.27, 3.30) mm, respectively (median (first quartile, third quartile)), (P < 0.001). The biopsy specimens revealed slightly thickened and tight bundles of collagen in the dermis. Three patients had amyloid deposits in the subcutaneous tissue, and one also showed these in the dermis. These were positively stained for insulin antibody. Repeated insulin injection procedures result in skin thickening. Increased collagen fibers and possibly amyloid deposition in the dermis may be involved. The results reaffirmed the importance of appropriate site rotation in insulin injection and revealed the usefulness of ultrasonographic skin examination in evaluating the self-injection procedure.


遺残坐骨動脈により生じた足背部難治性皮膚潰瘍の1例

遺残坐骨動脈により生じた足背部難治性皮膚潰瘍の1例


Bowen disease on the dorsum of the foot associated with human papillomavirus type 16

A 94 years old Japanese female was presented to our hospital with a skin lesion on her left foot. A physical examination found a markedly hyperkeratotic reddish-brown plaque, measuring 3 cm in diameter. A biopsy specimen showed prominent papillomatosis, hyperkeratosis, and atypical keratinocytes throughout the epidermis. Individual cell keratinization, multinucleated keratinocytes, and many keratinocytes with clear cytoplasm were seen. We excised the lesion, and the skin grafting was used for covering the skin defect. We investigated whether human papillomavirus (HPV) was present in the lesion, and HPV 16 DNA was detected using the polymerase chain reaction. Immunohistochemical analysis showed several HPV-positive cells in the upper epidermis. In addition, the tumor cells showed strong and diffuse expression of p16INK4a. Bowen disease (BD) is an intraepidermal squamous cell carcinoma. The precise pathogenesis of BD is unclear, but it involves various factors. HPV infection is one of these factors and is a well-known cause of BD of the genitalia and fingers. It has been shown that some BD lesions occurring at other locations are also associated with HPV. Dysregulation of the Rb/p16INK4a pathway is considered to play an important role in HPV-induced BD, but the precise mechanism remains to be elucidated. J. Med. Invest. 69 : 152-154, February, 2022.


Multiple skin ulceration and itch-scratch cycle in a diabetic patient

Diabetic patients sometimes present generalized pruritus. Severe itching can cause an itch-scratch cycle, resulting in distress and impaired quality of life, but skin ulceration is a rare manifestation.


下腿蜂窩織炎様の臨床像で再発した節外性NK/T細胞リンパ腫の1例

下腿蜂窩織炎様の臨床像で再発した節外性NK/T細胞リンパ腫の1例


足底に生じ，HPV33型DNAを検出したBowen病の1例

足底に生じ，HPV33型DNAを検出したBowen病の1例


急速に腎障害が進行したクリオグロブリン血症性血管炎

急速に腎障害が進行したクリオグロブリン血症性血管炎


顔面に皮疹を認めなかったBirt-Hogg-Dube症候群の1例

顔面に皮疹を認めなかったBirt-Hogg-Dube症候群の1例


疱疹状天疱瘡を合併した尋常性乾癬の1例

疱疹状天疱瘡を合併した尋常性乾癬の1例


入院中に生じた緑膿菌性毛包炎の母子例

入院中に生じた緑膿菌性毛包炎の母子例


Erythema Multiforme Associated with Chemical Burn Due to the Herbicides Alachlor

除草剤アラクロールによる化学熱傷後に生じた多形紅斑の1例


Condyloma acuminatum of the nipple resembling seborrheic keratosis

乳頭に生じ脂漏性角化症様の外観を呈した尖圭コンジローマの1例

A 25-year-old Japanese female presented with a skin lesion on her left nipple. The lesion had been present for three months and was increasing in size. A physical examination revealed a brown hyperkeratotic verrucous nodule on her left nipple. A histological examination of a biopsy specimen showed hyperkeratosis, papillo-matosis, and acanthosis. There were several koilocytes in the upper epidermis. Positive staining for human papillomavirus (HPV) particles by immunohistochemical analysis was seen in several cell nuclei at the upper malpighian layer. Mucous-type HPV DNA was detected in the lesion using the polymerase chain reaction (PCR), and it was identified as HPV type 6 by direct sequencing of the PCR product. We treated the patient by cryotherapy with liquid nitrogen, and the lesion disappeared. Condyloma acuminatum of the nipple is very rare. Interestingly, most reported clinical cases exhibit a seborrheic keratosis-like appearance. Dermatologists should consider condyloma acuminatum in cases in which seborrheic keratosis-like lesions are shown on the nipple.

25歳女．約3か月前より左乳頭部に皮疹が生じ，徐々に大きくなった．左乳頭部に角化傾向の強い暗褐色の疣状結節が，乳頭全体を覆うようにみられた．臨床像からは脂漏性角化症を考えたが，病理組織では，表皮は外方向性に乳頭状に肥厚し，表皮上層には多数のkoilocyteを認めた．抗human papillomavirus(HPV)抗体による免疫染色では，表皮顆粒層近くに陽性細胞を多数認めた．Polymerase chain reaction(PCR)によりHPVの検索を行ったところHPVのDNAが病変部から検出され，遺伝子配列はHPV6型と一致した．以上より，本例を乳頭部に生じた尖圭コンジローマと診断した．液体窒素治療により病変は消褪した．乳頭部に生じた尖圭コンジローマの報告は少ないが，興味深いことにほとんどの症例が，自験例の様に脂漏性角化症様の臨床像を呈している．乳頭に生じた脂漏性角化症様の病変に対しては常に尖圭コンジローマを鑑別に入れるべきである．


CASE REPORTS : Contact Dermatitis Syndrome Due to Betamethasone Valerate

症例 ベタメタゾン吉草酸エステルによる接触皮膚炎症候群の1例


A case of cutaneous anaplastic large cell lymphoma with pseudocarcinomatous hyperplasia

偽癌性増殖を伴った皮膚未分化大細胞リンパ腫の1例


オウゴンクジャクヒバによる接触皮膚炎症候群の1例

オウゴンクジャクヒバによる接触皮膚炎症候群の1例


留置針外套による接触皮膚炎

留置針外套による接触皮膚炎


透析による難治性皮膚瘙痒症に対するNarrow-band UVB療法の試み

透析による難治性皮膚瘙痒症に対するNarrow-band UVB療法の試み


ゴム加硫促進剤による接触皮膚炎症候群の1例

ゴム加硫促進剤による接触皮膚炎症候群の1例


ソラフェニブ投与中に生じたケラトアカントーマの1例

ソラフェニブ投与中に生じたケラトアカントーマの1例


ヒアレインミニ点眼液とミドリンP点眼液による接触皮膚炎

ヒアレインミニ点眼液とミドリンP点眼液による接触皮膚炎


A case of pyoderma gangrenosum associated with anterior necrotizing scleritis in a patient with ulcerative colitis.


A case of sarcoidosis diagnosed by granulomatous tattoo reactions

刺青部の肉芽腫病変を契機に診断に至ったサルコイドーシスの1例

Japanese Journal of Clinical Dermatology


Human papillomavirus infection in Bowen disease: Negative p53 expression, not p16(INK4a) overexpression, is correlated with human papillomavirus-associated Bowen disease

Genital Bowen disease (BD) has been linked to the high-risk types of human papillomavirus (HPV) infection. Recently, it has been recognized that HPV also can be associated with extragenital BD. HPV oncoproteins E6 and E7 interfere with the function of p53 and pRb, respectively, leading carcinogenesis. p16(INK4a) overexpression induced by inactivation of pRb is recognized as a surrogate marker for HPV-associated cervical cancer. In this study, we examined the presence of HPV DNA in 142 BD lesions by polymerase chain reaction (PCR), and determined the type of HPV by PCR restriction fragment length polymorphism or direct DNA sequencing. HPV DNA was detected in 66.7% of genital BD and 8.3% of extragenital BD. The types of HPV detected were HPV types 6, 16, 33, 52, 56, 58 and 59. We also investigated the expression of p16(INK4a) , pRb and p53 by immunohistochemistry. Positive expression was detected in 88.6% for p16(INK4a) , 25.2% for pRb, and 63.8% for p53. There was no significant difference in p16(INK4a) and pRb expression between HPV-positive and -negative BD. However, a strong correlation of HPV positivity with p53 negativity was found. A total of 66.7% of HPV-positive BD showed no p53 expression, whereas the corresponding rate was 32.8% of HPV-negative BD. This study demonstrated that HPV can participate in the development of BD, not only in the genital lesion, but also in extragenital lesion. p16(INK) (4a) overexpression is not a marker for HPV infection in BD. Instead, negative p53 expression is correlated with HPV-associated BD.


エキセナチドの皮下注射部位に生じた薬疹の1例

エキセナチドの皮下注射部位に生じた薬疹の1例


Improvement of Scalp Condition and Quality of Life through Proper Skin Care of Dry Scalp

Journal of Cosmetics Dermatological Sciences and Applications


リンパ節転移を伴った mucinous carcinoma of the skin の1例


A case of methylmalonic academia with acrodermatitis enteropathica-like eruption due to essential amino acids deficiency

症例報告 必須アミノ酸欠乏によると考えられる腸性肢端皮膚炎様皮疹を生じたメチルマロン酸血症の1例


A case of ichthyosiform mycosis fungoides

魚鱗癬様菌状息肉症の1例


Effect of the Biopsy Technique on the Survival Rate of Malignant Melanoma Patients

Cutaneous malignant melanoma has a poor prognosis. The detrimental effect of incisional biopsies on the outcome of malignant melanoma has been debated. The aim of this study was to determine the effect of the presence and type of biopsy on the prognosis of malignant melanoma. The medical records of 109 malignant melanoma patients treated at Tokushima University Hospital from 1983 to 2007 were reviewed. After excluding 28 cases with stage 0 disease or incomplete data, 81 cases were analyzed in detail with respect to patient sex, age, tumor site, clinical stage at diagnosis, presence of ulceration or lymph node metastasis, and prognosis. The five-year survival and five-year disease-free survival rates of patients who underwent incisional or excisional biopsies were compared with those who did not undergo a biopsy. The male-to-female ratio was 1:1.19. The mean age was 61.3 years (range, 19-93 years). The most common site was a lower extremity, and the most common clinical stage was stage II. No significant differences in clinicopathological features, five-year survival rates, and five-year disease-free survival rates were observed among the three groups. The presence and type of biopsy neither affected the metastatic rate nor the prognosis of malignant melanoma. The use of incisional biopsies is not encouraged because tumor thickness cannot be measured accurately. However, they may be helpful for confirming the diagnosis if an excisional biopsy cannot be performed.


Woolly hair nevus associated with digital abnormalities and auditory disturbance.


CASE REPORTS : Two Cases of Contact Dermatitis Due to Hair Dyes

症例 染毛剤による接触皮膚炎の2例


Increased lysophospholipase D activity of autotaxin in sera of patients with atopic dermatitis.


Xanthomas Associated with Primary Biliary Cirrhosis

原発性胆汁性肝硬変に合併した黄色腫の1例


ナローバンドUVB療法が奏効した多発性尿毒症性痒疹の1例

ナローバンドUVB療法が奏効した多発性尿毒症性痒疹の1例


A case of livedo vasculopathy successfully treated with dabigatran

ダビガトランが奏効したリベド血管症の1例


Epithelial stem cell mutations that promote squamous cell carcinoma metastasis.

Squamous cell carcinomas (SCCs) originate in stratified epithelia, with a small subset becoming metastatic. Epithelial stem cells are targets for driver mutations that give rise to SCCs, but it is unknown whether they contribute to oncogenic multipotency and metastasis. We developed a mouse model of SCC by targeting two frequent genetic mutations in human SCCs, oncogene Kras(G12D) activation and Smad4 deletion, to mouse keratin 15-expressing (K15+) stem cells. We show that transgenic mice developed multilineage tumors, including metastatic SCCs. Among cancer stem cell-enriched (CSC-enriched) populations, those with increased side population (SP) cells correlated with epithelial-mesenchymal transition (EMT) and lung metastasis. We show that microRNA-9 (miR-9) contributed to SP expansion and metastasis, and miR-9 inhibition reduced the number of SP cells and metastasis. Increased miR-9 was detected in metastatic human primary SCCs and SCC metastases, and miR-9-transduced human SCC cells exhibited increased invasion. We identified -catenin as a predominant miR-9 target. Increased miR-9 in human SCC metastases correlated with -catenin loss but not E-cadherin loss. Our results demonstrate that stem cells with Kras(G12D) activation and Smad4 depletion can produce tumors that are multipotent and susceptible to EMT and metastasis. Additionally, tumor initiation and metastatic properties of CSCs can be uncoupled, with miR-9 regulating the expansion of metastatic CSCs.


A Case of Leg Ulcers due to Juvenile-onset Deep Venous Thrombosis of the Leg Associated with Congenital Stenosis of the Inferior Vena Cava

先天性下大静脈狭窄症による若年発症下肢深部静脈血栓症に伴った下腿潰瘍の1例


Cutaneous Alternariosis on the Face Successfully Treated with a Combination of Terbinafine and Topical Heat Therapy

顔面に生じた皮膚アルテルナリア症-局所温熱療法を併用した1例-


Bowen disease of the palm associated with human papillomavirus 52.

Human papillomavirus (HPV) is a well-known risk factor for many human cancers, especially cervical cancers. Among the nonmelanoma skin cancers, Bowen disease (BD) of the genitalia and fingers has also been shown to be closely associated with the high-risk types of HPV, especially HPV16. We report a case of BD of the palm, which is a very rare location for BD. In addition to its rare location, HPV52, which is classified as a mucous high-risk HPV type, was detected in the lesion by PCR restriction fragment length polymorphism analysis. To our knowledge, this is the first reported case of BD associated with HPV52.


Hypomelanosis of Ito: A Case of Definitive Diagnosis without any Extracutaneous Complication at First Medical Examination and a Case of Presumptive Diagnosis

Hypomelanosis of Ito ―初診時に皮膚外合併症を伴わなかった確定診断例と疑診例―


Generalized malignant acanthosis nigricans with "deck-chair sign".


A case of Bowen's disease arising in a region of seborrheic keratosis

脂漏性角化症病巣内に発生したBowen病の1例

A 73-year-old Japanese woman was referred to our hospital because of a left leg skin tumor which was gradually growing. Clinical examination revealed a 14 × 13mm brownish keratotic plaque on her leg. Since an excisional biopsy specimen taken by a local dermatologist suggested squamous cell carcinoma, we performed an excisional biopsy. Histologically, the lesion consisted of proliferating keratinocytes. The periphery of the tumor showed reticulated seborrheic keratosis ; whereas in the center portion of the tumor, tumor cells consisted of atypical keratinocytes in the entire epidermis which was considered to be Bowen's disease. We should keep in mind that although rare, skin cancer, including Bowen's disease, could arise in a lesion of seborrheic keratosis.[Skin Cancer (Japan) 2013 ; 28 : 181-184]

73歳，女性．以前より左下腿外側に淡褐色の結節を自覚していたが，徐々に隆起してきた．地元の皮膚科医院で生検を受け，有棘細胞癌が疑われたため当科に紹介された．左下腿外側に14×13mmの不整形，扁平に隆起する角化性の淡褐色局面を認めた．摘出標本の病理組織では，病変は全体に好塩基性に染まる表皮細胞の増殖より成っていた．腫瘍の辺縁部は，異型性のない表皮細胞の増殖であり，偽角質嚢腫などを認め，脂漏性角化症の像であった．これに対し腫瘍の中央部は極性の乱れた，核の異型性を伴う表皮細胞が表皮全層性に増殖し，異常角化細胞も認めBowen病の所見を呈していた．同部では辺縁に比べKi67が強く発現していた．以上の組織所見から脂漏性角化症内に生じたBowen病と考えた．稀ではあるが良性の脂漏性角化症内にBowen病などの悪性病変を生じる事は，以前より報告されており，念頭に置いておく必要がある．


The involvement of fibroblast growth factor receptor signaling pathways in dermatofibroma and dermatofibrosarcoma protuberans.

Fibroblast growth factors (FGFs) and their receptors (FGFRs) control a wide range of biological functions; however, their involvement in the pathogenesis of dermatofibroma (DF) and dermatofibrosarcoma protuberans (DFSP) is currently unknown. In this study, we first confirmed the histological diagnosis by detecting fusion COL1A1-PDGFB transcripts in DFSP, and examined the expression of all FGFRs (FGFR1-4), some of their ligands (FGF1, 2, 9), and forkhead box N1 (FOXN1) as a downstream target of FGFR3 in DF and DFSP by immunohistochemical analysis. Although we failed to detect the expression of FGF1 and FGF9 as specific ligands for FGFR3 in DF, overexpression of FGFR3 and FOXN1 was observed in the epidermal regions of DF, suggesting that the epidermal regions of DF were similar to seborrhoeic keratosis both in terms of histological features and the activation of FGFR3/FOXN1. In addition, strong expression of FGF2 and FGFR4 was observed in the tumor lesions of DF. Expression patterns of FGFR3/FOXN1 and FGF2/FGFR4 in DF were in contrast with those of DFSP. The activation of FGFR signaling pathways may be not only relevant to the pathogenesis of DF, but also very useful in the differential diagnosis of DF and DFSP.

The Journal of Medical Investigation : JMI


Drug eruption induced by gonadotropin-releasing hormone analogs accompanying radiation-recall phenomenon.


Two cases of photosensitive drug eruption due to pirfenidone

ピルフェニドンによる光線過敏症の2例

Japanese Journal of Clinical Dermatology


足底に生じた筋上皮腫の1例


巨大な潰瘍を形成した頭部血管肉腫

巨大な潰瘍を形成した頭部血管肉腫


Drug-induced skin damage by intravenous administration of Nifekalant hydrochloride

塩酸ニフェカラントによる皮膚障害の1例


Squamous cell carcinoma of the scalp associated with human papillomavirus type 16.


Relapsing polychondritis associated with psoriasis vulgaris and alopecia areata.


Ichthyosis hystrix, Curth-Macklin type: a new sporadic case with a novel mutation of keratin 1.


Generalized hypopigmented macules after bone-marrow transplantation.


p53 prevents progression of nevi to melanoma predominantly through cell cycle regulation

p53 is the central member of a critical tumor suppressor pathway in virtually all tumor types, where it is silenced mainly by missense mutations. In melanoma, p53 predominantly remains wild type, thus its role has been neglected. To study the effect of p53 on melanocyte function and melanomagenesis, we crossed the `high-p53'Mdm4+/- mouse to the well-established TP-ras0/+ murine melanoma progression model. After treatment with the carcinogen dimethylbenzanthracene (DMBA), TP-ras0/+ mice on the Mdm4+/- background developed fewer tumors with a delay in the age of onset of melanomas compared to TP-ras0/+ mice. Furthermore, we observed a dramatic decrease in tumor growth, lack of metastasis with increased survival of TP-ras0/+: Mdm4+/- mice. Thus, p53 effectively prevented the conversion of small benign tumors to malignant and metastatic melanoma. p53 activation in cultured primary melanocyte and melanoma cell lines using Nutlin-3, a specific Mdm2 antagonist, supported these findings. Moreover, global gene expression and network analysis of Nutlin-3-treated primary human melanocytes indicated that cell cycle regulation through the p21WAF1/CIP1 signaling network may be the key anti-melanomagenic activity of p53.


Coexistence of giant blue nevus of the scalp with hair loss and alopecia areata.

A 43-year-old Japanese man presented with a 13-year history of a grayish macule measuring 7 cm in diameter with sparse hairs on the vertex. Histopathological examination demonstrated two types of melanocytes, spindle-shaped and ovoid cells, with abundant melanin aggregated around the upper part of the pilosebaceous apparatus. Fibrous, thick collagen bundles were also seen surrounding the upper part of the small hair follicles. There was no infiltration of melanocytes or lymphocytes in the lower dermis or adipose tissue. Based on these findings, a diagnosis of blue nevus, cellular type, was made. Giant cellular blue nevi on the scalp are rare, and 11 cases reported in the published work have shown characteristic features such as hair loss and cranial invasion of nevus cells. It should be noted that melanocytes of giant blue nevi have a high potential to damage other organs such as underlying bone and hair follicles. The patient also showed a typical lesion of alopecia areata on the left temporal which was successfully treated with topical corticosteroid.


Prevention of pressure ulcers in home care patients

きず・きずあと(創傷)治療:最近の進歩床ずれの在宅ケア

A large proportion of home care patients are at risk of pressure ulcer. The occurrence rate of pressure ulcer is higher in home care patients than that in the patients of hospitals and welfare facilities. The home care patients need long-term conservative treatment because of the depth of the pressure ulcers.Treatment of the pressure ulcers at home results in increase of caregivers burden. Therefore,prevention and early detection of pressure ulcers are important in home nursing. In early stage of pressure ulcers，``deep tissue injury''should be taken into consideration because of its progressive nature. It is a new concept which presents deep tissue damage remaining superficial skin intact.One of clinical features in this condition is induration in a deep layer.The past decade has seen a huge growth in the application of pressure relieving mattresses,absorbent products for urinary and faecal incontinence, and skin barrier products to prevention of the pressure ulcers. Economical, physical, and psychological burden of nursing at home should be decreased with an accumulation of these information and utilization of the products. Therefore, it is important for caregivers to consult with their care managers and acquire new knowledge and information.


Molecular carcinogenesis of squamous cell carcinomas of the skin.

Squamous cell carcinomas (SCCs) of the skin were suggested to develop through a multistep process that involves activation of proto-oncogenes and/or inactivation of tumor suppressor genes in the human skin keratinocytes. Exposure to ultra-violet (UV), especially UV-B, radiation is the most common cause for these genetic abnormalities in cells. We review causation of SCCs and genetic abnormalities in human SCCs with the current work. To elucidate the multistep process, we developed a method for examining the combinatorial function in vivo of plural genes in human keratinocytes. Using high efficiency retroviral transductions, we could express plural genes serially in normal human primary keratinocytes and use these cells to regenerate human skin on SCID mice. A combinatorial transduction of H-RasV12 and cyclin dependent kinase 4 (CDK4) produced human epidermal neoplasia resembling SCC. These findings were consistent with our previous results of mutation analysis in SCCs, one of which had both mutations of H-Ras gene and the INK4a locus. Therefore, it is suggested that a combination of these genetic abnormalities might be crucial to the carcinogenesis at least in a subset of SCCs.

The Journal of Medical Investigation : JMI


足底に難治性潰瘍を伴ったWerner症候群の3例 --- WRN遺伝子変異の検討


リップクリーム中のミツロウによる接触皮膚炎

リップクリーム中のミツロウによる接触皮膚炎


Multiple Bowen disease lesions with the eyeliner sign in a psoriasis patient after long-term narrow-band ultraviolet B light therapy.

The American Journal of Dermatopathology


A case of childhood granulomatous periorificial dermatitis mimicking lichen nitidus


A case of an insect bite-like reaction in a patient with angioimmunoblastic T-cell lymphoma.


Case of papular acantholytic dyskeratosis of the genital area successfully treated with topical vitamin D3 ointment


Chemotherapy-induced inflammation of seborrheic keratoses due to pemetrexed treatment


Case of multiple Bowen diseases associated with human papillomavirus type 16 in a patient with atopic dermatitis.


Case of nevoid basal cell carcinoma syndrome with multiple cutaneous keratocysts.


Primary cutaneous mucormycosis caused by Mucor irregularis in an immunocompetent patient


Woolly hair nevus: neonatal alopecia can be an initial manifestation.


Improvement of palmoplantar pustulosis lesions after angioplasty for Leriche syndrome.

Although a wide range of treatments have been used in the treatment of palmoplantar pustulosis (PPP), PPP is still very difficult to treat. We report a patient who had a dramatic reduction in PPP lesions after bypass surgery for Leriche syndrome. We assume that improved blood circulation had a crucial impact in reducing PPP lesions and suggest improving blood circulation could be another treatment option.


A case of lichen planus significantly improved after topical heparinoid treatment


Multiple epidermal cysts in hemodialysis patients


Verrucous skin lesions on the feet in diabetic neuropathy successfully treated with topical maxacalcitol


Verrucous extramammary Pagets disease accompanying human papillomavirus 40-associated condyloma acuminatum: importance of multiple skin biopsies


Multiple pilosebaceous cysts induced by topical steroid therapy


Lack of association between extramammary Pagets disease and human papillomavirus infection