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Research Activity

Field of Study

Food Science, Functional Food Science

Subject of Study

Mechanism of lipid peroxidation and oxidative DNA damage, Inhibitory effect of antioxidants in food against oxidative stress (polyphenol, flavonoids, oxidative stress, lipid peroxidation, mass spectrometry)

Book / Paper

Book:

1. Yoshichika Kawai :
第3章 3.炭水化物とその変化 4.脂質とその変化,
KENPAKUSHA, May 2017.
2. Junji Terao, Kaeko Murota and Yoshichika Kawai :
Recent Advances in Polyphenol Research, Volume2, --- Chapter8 Antiatheroscletic Effects of Dietary Flavonoids:Insight into their Molecular Action Mechanism at the Target Site ---,
Wiley-Blackwell, Jul. 2010.

Academic Paper (Judged Full Paper):

1. Erika Nuka, Kohta Ohnishi, Junji Terao and Yoshichika Kawai :
ATP/P2X7 receptor signaling as a potential anti-inflammatory target of natural polyphenols.,
PLoS ONE, Vol.13, No.9, e0204229, 2018.
(Tokushima University Institutional Repository: 114342,   DOI: 10.1371/journal.pone.0204229,   PubMed: 30248132)
2. Liu Litong, Nagai Izumi, Gao Ying, Matsushima Yoshibumi, Yoshichika Kawai and Sayama Kazutoshi :
Effects of catechins and caffeine on the development of atherosclerosis in mice,
Bioscience, Biotechnology, and Biochemistry, Vol.81, No.10, 1948-1955, 2017.
(DOI: 10.1080/09168451.2017.1364618,   PubMed: 28891395,   Elsevier: Scopus)
3. Ishisaka Akari, Ikushiro Shinichi, Takeuchi Mie, Araki1 Yukako, Juri Maki, Yoshiki Yui, Yoshichika Kawai, Niwa Toshio, Kitamoto Noritoshi, Sakaki Toshiyuki, Ishikawa Hirohito and Kato Yoji :
In vivo absorption and metabolism of leptosperin and methyl syringate, abundantly present in manuka honey,
Molecular Nutrition & Food Research, Vol.61, No.9, 1700122, 2017.
(DOI: 10.1002/mnfr.201700122,   PubMed: 28444960,   Elsevier: Scopus)
4. Erika Nuka, Susumu Tomono, Akari Ishisaka, Yoji Kato, Noriyuki Miyoshi and Yoshichika Kawai :
Metal-catalyzed oxidation of 2-alkenals generates genotoxic 4-oxo-2-alkenals during lipid peroxidation.,
Bioscience, Biotechnology, and Biochemistry, Vol.80, No.10, 2007-2013, 2016.
(Tokushima University Institutional Repository: 111621,   DOI: 10.1080/09168451.2016.1191334,   PubMed: 27281652)
5. Maerjianghan Abuduli, Hirokazu Ohminami, Tamaki Otani, Hitoshi Kubo, Haruka Ueda, Yoshichika Kawai, Masashi Masuda, Hisami Okumura, Hiroshi Sakaue, Hironori Yamamoto, Eiji Takeda and Yutaka Taketani :
Effects of dietary phosphate on glucose and lipid metabolism.,
American Journal of Physiology, Endocrinology and Metabolism, Vol.310, No.7, E526-E538, 2016.
(Tokushima University Institutional Repository: 109976,   DOI: 10.1152/ajpendo.00234.2015,   PubMed: 26786774)
6. Akari Ishisaka, Rie Mukai, Junji Terao, Noriyuki Shibata and Yoshichika Kawai :
Specific localization of quercetin-3-O-glucuronide in human brain.,
Archives of Biochemistry and Biophysics, 2014.
(DOI: 10.1016/j.abb.2014.05.025,   PubMed: 24893148)
7. Akari Ishisaka, Kyuichi Kawabata, Satomi Miki, Yuko Shiba, Shoko Minekawa, Tomomi Nishikawa, Rie Mukai, Junji Terao and Yoshichika Kawai :
Mitochondrial dysfunction leads to deconjugation of quercetin glucuronides in inflammatory macrophages.,
PLoS ONE, Vol.8, No.11, e80843, 2013.
(DOI: 10.1371/journal.pone.0080843,   PubMed: 24260490)
8. Toshiyuki Nakamura, Ayako Noma, Sachiko Shimada, Nanase Ishii, Noriko Bando, Yoshichika Kawai and Junji Terao :
Non-selective distribution of isomeric cholesterol hydroperoxides to microdomains in cell membranes and activation of matrix metalloproteinase activity in a model of dermal cells.,
Chemistry and Physics of Lipids, Vol.174, 17-23, 2013.
(DOI: 10.1016/j.chemphyslip.2013.05.004,   PubMed: 23751409)
9. Mari Kotosai, Sachiko Shimada, Mai Kanda, Namiko Matsuda, Keiko Sekido, Yoshibumi Shimizu, Akira Tokumura, Toshiyuki Nakamura, Kaeko Murota, Yoshichika Kawai and Junji Terao :
Plasma HDL reduces nonesterified fatty acid hydroperoxides originating from oxidized LDL.,
Lipids, Vol.48, No.6, 569-578, 2013.
(DOI: 10.1007/s11745-013-3779-1,   PubMed: 23494578,   Elsevier: Scopus)
10. Kohta Ohnishi, Shinya Ohkura, Erina Nakahata, Akari Ishisaka, Yoshichika Kawai, Junji Terao, Taiki Mori, Takeshi Ishii, Tsutomu Nakayama, Noriyuki Kioka, Yasutaka Ikeda, Minoru Akiyama, Kazuhiro Irie, Akira Murakami and Shinya Matsumoto :
Non-specific protein modification by a phytochemical induce heat shock response for self-defense.,
PLoS ONE, Vol.8, No.3, e58641, 2013.
(DOI: 10.1371/journal.pone.0058641,   PubMed: 23536805)
11. Hiroharu Kobayashi, Yoriko Yamashita, Akira Iwase, Yutaka Yoshikawa, Hiroyuki Yasui, Yoshichika Kawai, Koji Uchida, Nozomi Uno, Shinya Akatsuka, Takashi Takahashi, Fumitaka Kikkawa and Shinya Toyokuni :
The ferroimmunomodulatory role of ectopic endometriotic stromal cells in ovarian endometriosis.,
Fertility and Sterility, Vol.98, No.2, 415-422.e12, 2012.
(DOI: 10.1016/j.fertnstert.2012.04.047,   PubMed: 22633261)
12. In-Hye Lee, Yoshichika Kawai, M Maria Fergusson, I Ilsa Rovira, R Alexander J Bishop, Noboru Motoyama, Liu Cao and Toren Finkel :
Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress.,
Science, Vol.336, No.6078, 225-228, 2012.
(DOI: 10.1126/science.1218395,   PubMed: 22499945)
13. Keisuke Ishizawa, Masanori Yoshizumi, Yoshichika Kawai, Junji Terao, Yoshitaka Kihira, Yasumasa Ikeda, Shuhei Tomita, Kazuo Minakuchi, Koichiro Tsuchiya and Toshiaki Tamaki :
Pharmacology in health food: Metabolism of quercetin in vivo and its protective effect against arteriosclerosis,
Journal of Pharmacological Sciences, Vol.115, No.4, 466-470, 2011.
(DOI: 10.1254/jphs.10R38FM,   PubMed: 21436601)
14. Saki Yoshino, Aya Hara, Hiroyuki Sakakibara, Kyuichi Kawabata, Akira Tokumura, Akari Ishisaka, Yoshichika Kawai and Junji Terao :
Effect of quercetin and glucuronide metabolites on the monoamine oxidase-A reaction in mouse brain mitochondria.,
Nutrition, 2011.
(DOI: 10.1016/j.nut.2010.09.002,   PubMed: 21371861)
15. Junji Terao, Kaeko Murota and Yoshichika Kawai :
Conjugated quercetin glucuronides as bioactive metabolites and precursors of aglycone in vivo,
Food & Function, Vol.2, No.1, 11-17, 2011.
(DOI: 10.1039/c0fo00106f,   PubMed: 21773581)
16. Akiyuki Yokoyama, Hiroyuki Sakakibara, Alan Crozier, Yoshichika Kawai, Asako Matsui, Junji Terao, Shigenori Kumazawa and Kayoko Shimoi :
Quercetin metabolites and protection against peroxynitrite-induced oxidative hepatic injury in rats.,
Free Radical Research, Vol.43, No.10, 913-921, 2009.
(DOI: 10.1080/10715760903137010,   PubMed: 19669999)
17. Kyuichi Kawabata, Yoshichika Kawai and Junji Terao :
Suppressive effect of quercetin on acute stress-induced hypothalamic-pituitary-adrenal axis response in Wistar rats.,
The Journal of Nutritional Biochemistry, Vol.21, No.5, 374-380, 2009.
(DOI: 10.1016/j.jnutbio.2009.01.008,   PubMed: 19423323)
18. Yoshichika Kawai, Satomi Saito, Tomomi Nishikawa, Akari Ishisaka, Kaeko Murota and Junji Terao :
Different profiles of quercetin metabolites in rat plasma: comparison of two administration methods.,
Bioscience, Biotechnology, and Biochemistry, Vol.73, No.3, 517-523, 2009.
(DOI: 10.1271/bbb.80516,   PubMed: 19270373)
19. Yoshichika Kawai, Hiroko Tanaka, Kaeko Murota, Michitaka Naito and Junji Terao :
(-)-Epicatechin gallate accumulates in foamy macrophages in human atherosclerotic aorta: implication in the anti-atherosclerotic actions of tea catechins.,
Biochemical and Biophysical Research Communications, Vol.374, No.3, 527-532, 2008.
(DOI: 10.1016/j.bbrc.2008.07.086,   PubMed: 18657514)
20. Yuko Minami, Kyuichi Kawabata, Yoshiaki Kubo, Seiji Arase, Katsuya Hirasaka, Takeshi Nikawa, Noriko Bando, Yoshichika Kawai and Junji Terao :
Peroxidized cholesterol-induced matrix metalloproteinase-9 activation and its suppression by dietary beta-carotene in photoaging of hairless mouse skin.,
The Journal of Nutritional Biochemistry, Vol.20, No.5, 389-398, 2008.
(DOI: 10.1016/j.jnutbio.2008.04.010,   PubMed: 18656335)
21. Yuko Shiba, Takashi Kinoshita, Hiroshi Chuman, Yutaka Taketani, Eiji Takeda, Yoji Kato, Michitaka Naito, Kyuichi Kawabata, Akari Ishisaka, Junji Terao and Yoshichika Kawai :
Flavonoids as Substrates and Inhibitors of Myeloperoxidase : Molecular Actions of Aglycone and Metabolites,
Chemical Research in Toxicology, Vol.21, No.8, 1600-1609, 2008.
(DOI: 10.1021/tx8000835,   PubMed: 18620432)
22. Hiroyuki Sakakibara, Saki Yoshino, Toshitsugu Miyazaki, Yoshichika Kawai and Junji Terao :
Antidepressant-like Effect of Ginseng (Panax ginseng C.A. Meyer) in Behavioral Models,
Journal of Clinical Biochemistry and Nutrition, Vol.43, No.Suppl.1, 255-258, 2008.
23. Yuko Minami, Kanako Yokoyama, Noriko Bando, Yoshichika Kawai and Junji Terao :
Occurrence of singlet oxygen oxygenation of oleic acid and linoleic acid in the skin of live mice.,
Free Radical Research, Vol.42, No.3, 197-204, 2008.
(DOI: 10.1080/10715760801948088,   PubMed: 18344113)
24. Yoshichika Kawai, Akari Ishisaka, Satomi Saito, Koji Uchida, Noriyuki Shibata, Makio Kobayashi, Yoshiko Fukuchi, Michitaka Naito and Junji Terao :
Immunochemical detection of flavonoid glycosides: development, specificity, and application of novel monoclonal antibodies.,
Archives of Biochemistry and Biophysics, Vol.476, No.2, 124-132, 2008.
(DOI: 10.1016/j.abb.2008.01.022,   PubMed: 18267102)
25. Yoshichika Kawai, Tomomi Nishikawa, Yuko Shiba, Satomi Saito, Kaeko Murota, Noriyuki Shibata, Makio Kobayashi, Masaya Kanayama, Koji Uchida and Junji Terao :
Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries: implication in the anti-atherosclerotic mechanism of dietary flavonoids.,
The Journal of Biological Chemistry, Vol.283, No.14, 9424-9434, 2008.
(DOI: 10.1074/jbc.M706571200,   PubMed: 18199750)
26. Hiroyuki Sakakibara, Saki Yoshino, Yoshichika Kawai and Junji Terao :
Antidepressant-like effect of onion (Allium cepa L.) powder in a rat behavioral model of depression.,
Bioscience, Biotechnology, and Biochemistry, Vol.72, No.1, 94-100, 2008.
(DOI: 10.1271/bbb.70454,   PubMed: 18175926)
27. Junji Terao, Yoshichika Kawai and Kaeko Murota :
Vegetable flavonoids and cardiovascular disease.,
Asia Pacific Journal of Clinical Nutrition, Vol.17, No.Suppl 1, 291-293, 2008.
(PubMed: 18296359)
28. Minami Yuko, Yokoi sayuri, Setoyama Mari, Noriko Bando, Takeda Sayaka, Yoshichika Kawai and Junji Terao :
Combination of TLC blotting and gas chromatography-mass spectrometry for analysis of peroxidized cholesterol,
Lipids, Vol.42, No.11, 1055-1063, 2007.
(DOI: 10.1007/s11745-007-3099-4,   PubMed: 17701239,   Elsevier: Scopus)
29. Kaeko Murota, Azusa Hotta, Hikaru Ido, Yoshichika Kawai, Jae-Hak Moon, Keiko Sekido, Hiroki Hayashi, Takahiro Inakuma and Junji Terao :
Antioxidant capacity of albumin-bound quercetin metabolites after onion consumption in humans.,
The Journal of Medical Investigation : JMI, Vol.54, No.3-4, 370-374, 2007.
(Tokushima University Institutional Repository: 111544,   DOI: 10.2152/jmi.54.370,   PubMed: 17878690)
30. Dong-Soon Kim, Hideki Takai, Masato Arai, Shouta Araki, Masaru Mezawa, Yoshichika Kawai, Kaeko Murota, Junji Terao and Yorimasa Ogata :
Effects of Quercetin and Quercetin 3-Glucuronide on the Expression of Bone Sialoprotein Gene,
Journal of Cellular Biochemistry, Vol.101, No.3, 790-800, 2007.
(DOI: 10.1002/jcb.21233,   PubMed: 17243115)
31. Yoshichika Kawai, Sayaka Takeda and Junji Terao :
Lipidomic analysis for lipid peroxidation-derived aldehydes using gas chromatography-mass spectrometry,
Chemical Research in Toxicology, Vol.20, No.1, 99-107, 2007.
(DOI: 10.1021/tx060199e,   PubMed: 17226932)
32. Yoshichika Kawai, Mariko Miyoshi, Jae-Hak Moon and Junji Terao :
Detection of cholesteryl ester hydroperoxide isomers using gas chromatography-mass spectrometry combined with thin-layer chromatography blotting.,
Analytical Biochemistry: Methods in the Biological Sciences, Vol.360, No.1, 130-137, 2007.
(DOI: 10.1016/j.ab.2006.09.028,   PubMed: 17097596)
33. Yoshichika Kawai, Hitomi Kiyokawa, Yuki Kimura, Yoji Kato, Koichiro Tsuchiya and Junji Terao :
Hypochlorous acid-derived modification of phospholipids: characterization of aminophospholipids as regulatory molecules for lipid peroxidation.,
Biochemistry, Vol.45, No.47, 14201-14211, 2006.
(DOI: 10.1021/bi0610909,   PubMed: 17115715)
34. Shinya Akatsuka, Than Tin Aung, Khokon Kumar Dutta, Li Jiang, Wen-Hua Lee, Yu-Ting Liu, Janice Onuki, Tomoyuki Shirase, Kyoko Yamasaki, Hirotomo Ochi, Yuji Naito, Toshikazu Yoshikawa, Hiroshi Kasai, Yohei Tominaga, Kunihiko Sakumi, Yusaku Nakabeppu, Yoshichika Kawai, Koji Uchida, Aiichi Yamasaki, Tatsuaki Tsuruyama, Yoshihiro Yamada and Shinya Toyokuni :
Contrasting genome-wide distribution of 8-hydroxyguanine and acrolein-modified adenine during oxidative stress-induced renal carcinogenesis,
The American Journal of Pathology, Vol.169, No.4, 1328-1342, 2006.
(DOI: 10.2353/ajpath.2006.051280,   PubMed: 17003489)
35. Mutsuko Shirai, Yoshichika Kawai, Rintaro Yamanishi, Takashi KInoshita, Hiroshi Chuman and Junji Terao :
Effect of a conjugated quercetin metabolite, quercetin 3-glucuronide, on lipid hydroperoxide-dependent formation of reactive oxygen species in differentiated PC-12 cells,
Free Radical Research, Vol.40, No.10, 1047-1053, 2006.
(DOI: 10.1080/10715760600794287,   PubMed: 17015249)
36. Hiroyuki Sakakibara, Kaori Ishida, Oliver Grundmann, Jun-ichiro Nakajima, Shujiro Seo, Veronika Butterweck, Yuko Minami, Satomi Saito, Yoshichika Kawai, Yutaka Nakaya and Junji Terao :
Antidepressant effect of extracts from Ginkgo biloba leaves in behavioral models,
Biological & Pharmaceutical Bulletin, Vol.29, No.8, 1767-1770, 2006.
(DOI: 10.1248/bpb.29.1767,   PubMed: 16880641)
37. Yoshichika Kawai, Hiroyuki Fujii, Miki Okada, Yoshikazu Tsuchie, Koji Uchida and Toshihiko Osawa :
Formation of Ne-(succinyl)lysine in vivo: a novel marker for docosahexaenoic acid-derived protein modification,
Journal of Lipid Research, Vol.47, No.7, 1386-1398, 2006.
(DOI: 10.1194/jlr.M600091-JLR200,   PubMed: 16582421)
38. Mitsugu Akagawa, Sohei Ito, Kazuo Toyoda, Yoshihisa Ishii, Emi Tatsuda, Takahiro Shibata, Satoru Yamaguchi, Yoshichika Kawai, Kousuke Ishino, Yusuke Kishi, Takahiro Adachi, Takeshi Tsubata, Yoshinari Takasaki, Nobutaka Hattori, Tsukasa Matsuda and Uchida Koji :
Bispecific abs against modified protein and DNA with oxidized lipids,
Proceedings of the National Academy of Sciences of the United States of America, Vol.103, No.16, 6160-6165, 2006.
(DOI: 10.1073/pnas.0600865103,   PubMed: 16603628)
39. Takahiro Shibata, Kumiko Iio, Yoshichika Kawai, Noriyuki Shibata, Motoko Kawaguchi, Sono Toi, Makio Kobayashi, Masahiko Kobayashi, Kenichi Yamamoto and Koji Uchida :
Identification of a Lipid Peroxidation Product as a Potential Trigger of the p53 Pathway,
The Journal of Biological Chemistry, Vol.281, No.2, 1196-1204, 2006.
(DOI: 10.1074/jbc.M509065200,   PubMed: 16251187,   Elsevier: Scopus)
40. Takashi Kinoshita, Lepp Zsolt, Yoshichika Kawai, Junji Terao and Hiroshi Chuman :
An Integrated Database of Flavonoids,
BioFactors, Vol.26, No.3, 179-188, 2006.
(PubMed: 16971749,   Elsevier: Scopus)
41. Mikiko Ito, Sakiko Haito, Mari Furumoto, Yoshichika Kawai, Junji Terao and Ken-ichi Miyamoto :
Approach to novel functional foods for stress control 4. Regulation of serotonin transporter by food factors,
The Journal of Medical Investigation : JMI, Vol.52, No.0, 245-248, 2005.
(Tokushima University Institutional Repository: 111559,   DOI: 10.2152/jmi.52.245,   PubMed: 16366509,   CiNii: 110002276828)
42. Mutsuko Shirai, Yoshichika Kawai, Rintaro Yamanishi and Junji Terao :
Approach to novel functional foods for stress control 5. Antioxidant activity profiles of antidepressant herbs and their active components,
The Journal of Medical Investigation : JMI, Vol.52, 249-251, 2005.
(Tokushima University Institutional Repository: 111560,   DOI: 10.2152/jmi.52.249,   PubMed: 16366510,   Elsevier: Scopus)
43. Hiroyuki Sakakibara, Kaori Ishida, Yuki Izawa, Yuko Minami, Satomi Saito, Yoshichika Kawai, Veronika Butterweck, Toshiaki Tamaki, Yutaka Nakaya and Junji Terao :
Effects of forced swimming stress on rat brain function,
The Journal of Medical Investigation : JMI, Vol.52, No.Suppl., 300-3001, 2005.
(Tokushima University Institutional Repository: 111587,   DOI: 10.2152/jmi.52.300,   PubMed: 16366521)
44. Yoji Kato, Yoshichika Kawai, Hiroshi Morinaga, Hajime Kondo, Natsuko Dozaki, Noritoshi Kitamoto and Toshihiko Osawa :
Immunogenicity of a brominated protein and successive establishment of a monoclonal antibody to di-halogenated tyrosine,
Free Radical Biology and Medicine, Vol.38, No.1, 24-31, 2005.
(DOI: 10.1016/j.freeradbiomed.2004.09.013,   PubMed: 15589368)
45. Yoji Kato, Akihiro Yoshida, Michitaka Naito, Yoshichika Kawai, Kentaro Tsuji, Noritoshi Kitamoto and Toshihiko Osawa :
Identification and quantification of N -(Hexanoyl)lysine in human urine by liquid chromatography/tandem mass spectrometry,
Free Radical Biology and Medicine, Vol.37, No.11, 1864-1874, 2004.
(DOI: 10.1016/j.freeradbiomed.2004.09.007,   PubMed: 15528045)
46. Kensaku Kamada, Shinji Goto, Tomohiro Okunaga, Yoshito Ihara, Kentaro Tsuji, Yoshichika Kawai, Koji Uchida, Toshihiko Osawa, Takayuki Matsuo, Izumi Nagata and Takahito Kondo :
Nuclear glutathione S-transferase Pi prevents apoptosis by reducing the oxidative stress induced formation of exocyclic DNA adducts,
Free Radical Biology and Medicine, Vol.37, No.11, 1875-1884, 2004.
(DOI: 10.1016/j.freeradbiomed.2004.09.002,   PubMed: 15528046)
47. Yoshichika Kawai, Hiroshi Morinaga, Hajime Kondo, Noriyuki Miyoshi, Yoshimasa Nakamura, Koji Uchida and Toshihiko Osawa :
Endogenous formation of novel halogenated 2'-deoxycytidine: Hypohalous acid-mediated DNA modification at the site of inflammation,
The Journal of Biological Chemistry, Vol.279, No.49, 51241-51249, 2004.
(DOI: 10.1074/jbc.M408210200,   PubMed: 15364942)
48. Satoshi Yamada, Tadashi Funada, Noriyuki Shibata, Yoshichika Kawai, Emi Tatsuda, Atsunori Furuhata and Koji Uchida :
Protein-bound 4-hydroxy-2-hexenal as a marker of oxidized n-3 polyunsaturated fatty acids,
Journal of Lipid Research, Vol.45, No.4, 626-634, 2004.
(DOI: 10.1194/jlr.M300376-JLR200,   PubMed: 14729859)
49. Yoshichika Kawai, Koji Uchida and Toshihiko Osawa :
2'-Deoxycytidine in free nucleosides and double-stranded DNA as the major target by lipid peroxidation products,
Free Radical Biology and Medicine, Vol.36, No.5, 529-541, 2004.
(DOI: 10.1016/j.freeradbiomed.2003.12.006,   PubMed: 14980698)
50. Yoshichika Kawai, Hiroyuki Fujii, Yoji Kato, Michiteru Kodama, Michitaka Naito, Koji Uchida and Toshihiko Osawa :
Esterified lipid hydroperoxide-derived modification of protein: formation of a carboxyalkylamide-type lysine adduct in human atherosclerotic lesions,
Biochemical and Biophysical Research Communications, Vol.313, No.2, 271-276, 2004.
(DOI: 10.1016/j.bbrc.2003.11.123,   PubMed: 14684156)
51. Yoshichika Kawai, Atsunori Furuhata, Shinya Toyokuni, Yasuaki Aratani and Koji Uchida :
Formation of acrolein-derived 2'-deoxyadenosine adduct in an iron-induced carcinogenesis model,
The Journal of Biological Chemistry, Vol.278, No.50, 50346-50354, 2003.
(DOI: 10.1074/jbc.M309057200,   PubMed: 14522963)
52. Kentaro Tsuji, Yoshichika Kawai, Yoji Kato and Toshihiko Osawa :
Formation of N-(hexanoyl)ethanolamine, a novel phosphatidylethanolamine adduct, during the oxidation of erythrocyte membrane and low-density lipoprotein,
Biochemical and Biophysical Research Communications, Vol.306, No.3, 706-711, 2003.
(DOI: 10.1016/S0006-291X(03)01038-6,   PubMed: 12810076)
53. Yoshichika Kawai, Yoji Kato, Hiroyuki Fujii, Yuko Makino, Yoko Mori, Michitaka Naito and Toshihiko Osawa :
Immunochemical detection of a novel lysine adduct using an antibody to linoleic acid hydroperoxide-modified protein,
Journal of Lipid Research, Vol.44, No.6, 1124-1131, 2003.
(DOI: 10.1194/jlr.M200442-JLR200,   PubMed: 12700336)
54. Yoshichika Kawai, Akiko Saito, Noriyuki Shibata, Makio Kobayashi, Satoshi Yamada, Toshihiko Osawa and Koji Uchida :
Covalent binding of oxidized cholesteryl esters to protein: Implications for oxidative modification of low density lipoprotein and atherosclerosis,
The Journal of Biological Chemistry, Vol.278, No.23, 21040-21049, 2003.
(DOI: 10.1074/jbc.M212426200,   PubMed: 12663661)
55. Yoshichika Kawai, Yoji Kato, Dai Nakae, Osamu Kusuoka, Yoichi Konishi, Koji Uchida and Toshihiko Osawa :
Immunohistochemical detection of a substituted 1,N2-ethenodeoxyguanosine adduct by ω-6 polyunsaturated fatty acid hydroperoxides in the liver of rats fed a choline-deficient, L-amino acid-defined diet,
Carcinogenesis, Vol.23, No.3, 485-489, 2002.
(DOI: 10.1093/carcin/23.3.485,   PubMed: 11895864,   Elsevier: Scopus)
56. Yoji Kato, Noritoshi Kitamoto, Yoshichika Kawai and Tosihiko Osawa :
The hydrogen peroxide/copper ion system, but not other metal-catalyzed oxidation system, produces protein-bound dityrosine,
Free Radical Biology and Medicine, Vol.31, No.5, 624-632, 2001.
(DOI: 10.1016/S0891-5849(01)00623-2,   PubMed: 11522447,   Elsevier: Scopus)
57. Myung-Hwa Kang, Yoshichika Kawai, Michitaka Naito and Toshihiko Osawa :
Dietary defatted sesame flour decreases susceptibility to oxidative stress in hypercholesterolemic rabbits,
The Journal of Nutrition, Vol.129, No.10, 1885-1890, 1999.
(PubMed: 10498763,   Elsevier: Scopus)

Review, Commentary:

1. Yoshichika Kawai and Nuka Erika :
Abundance of DNA adducts of 4-oxo-2-alkenals, lipid peroxidation-derived highly reactive genotoxins,
Journal of Clinical Biochemistry and Nutrition, Vol.62, No.1, 3-10, Dec. 2017.
(DOI: 10.3164/jcbn.17-90,   PubMed: 29362517)
2. Yoshichika Kawai :
Beta-Glucuronidase activity and mitochondrial dysfunction: the sites where flavonoid glucuronides act as anti-inflammatory agents.,
Journal of Clinical Biochemistry and Nutrition, Vol.54, No.3, 145-150, Apr. 2014.
(DOI: 10.3164/jcbn.14-9,   PubMed: 24895476)
3. 室田 佳恵子, Yoshichika Kawai and Junji Terao :
Transport Mechanism of Dietary Flavonoids and their Metabolites,
ビタミン, Vol.84, No.12, 589-598, Dec. 2010.
(CiNii: 110008006991)
4. Yoshichika Kawai and Junji Terao :
ケルセチンの生体内標的部位と作用機構,
化学と生物, Vol.47, No.11, 746-747, Nov. 2009.
5. Junji Terao, Yoshichika Kawai and Kaeko Murota :
Development in physiological function of polyphenols,
Journal of Clinical and Experimental Medicine, 208-211, Oct. 2006.

Proceeding of International Conference:

1. Naomi Kanoh, Nuka Erika, Mao Aoki, Kotono Noguchi, Miyuki Uemura, Hirotaka Sekiguchi, Keita Sutoh, Koji Usumi, Kohta Ohnishi and Yoshichika Kawai :
Analysis of food-derived nucleic acids and their effects on claudin-4 mRNA expression in differentiated Caco-2 models,
ICoFF2019, Dec. 2019.
2. Kohta Ohnishi, Moe FUJIMOTO, Maiko SAKAI, Teppei FUKUDA, Aika OHNISHI, Hirokazu Ohminami, Masashi Masuda, Hisami Okumura, Yoshichika Kawai and Yutaka Taketani :
Exploration of bioactive food factors for the control of autophagy flux,
The 7th International Conference on Food Factors, Dec. 2019.
3. Maiko SAKAI, Kohta Ohnishi, Teppei FUKUDA, Masashi Masuda, Naomi Kanoh, Hisami Okumura, Yoshichika Kawai and Yutaka Taketani :
mTORC2 signaling is critical for lysosomal activation by isorhamnetin treatment in J774.1.,
FAOPS2019, Mar. 2019.
4. Yoshida Risa, Masashi Masuda, Mori Yuki, Niida Yuki, Adachi Yuichiro, Kohta Ohnishi, Hisami Okumura, Yoshichika Kawai and Yutaka Taketani :
Sulforaphane induces lipolysis via lipophagy in mouse adipocyte,
Kern Lipid Conference, Vail, Colorado, Aug. 2018.
5. Niida Yuki, Masashi Masuda, Yoshizawa Aika, Adachi Yuichiro, Yimamu Yilimulati, Kabutoya Serina, Yoshida Risa, Hisami Okumura, Yoshichika Kawai, Miyazaki Makoto, Hironori Yamamoto and Yutaka Taketani :
Abnormal lipid metabolism in skeletal muscle mediates chronic kidney disease-induced sarcopenia,
ASN Kidney Week 2017, New Orleans, Nov. 2017.
6. Nuka Erika, Kohta Ohnishi, Junji Terao and Yoshichika Kawai :
Signaling pathways of ATP and adenosine could be anti-inflammatory targets of polyphenols,
8th International Conference on Polyphenols and Health, Oct. 2017.
7. Arai Hikaru, Koike Taisuke and Yoshichika Kawai :
Chemical properties and bioavailability of taxifolin and related flavonoids,
8th International Conference on Polyphenols and Health, Oct. 2017.
8. Yoshichika Kawai :
Specific localization and antioxidant activity of dietary flavonoid quercetin in brain,
20 International Symposium on Signal Transduction at Blood-Brain Barriers, Sep. 2017.
9. Hiroshi Tatano, Hisami Okumura, Daisuke Kajiura, C Kondo, A Hirayama, Kazuaki Mawatari, Yoshichika Kawai, Masashi Masuda and Yutaka Taketani :
Exploring the impact of consuming different types of meat on metabolome profiles using a GC-MS metabolomics approach,
11th Metabolomics Society Conference, Dublin, Jul. 2016.
10. Erika Nuka, Kohta Ohnishi, Junji Terao, Yoshichika Kawai and Toshiyuki Sakaki :
Polyphenols modulate ATP-induced inflammation in macrophages,
6th International conference on Food Factors (ICoFF2015), Nov. 2015.
11. Kenji Kurokawa, Erika Nuka, Kohta Ohnishi, Shin-ichi Ikushiro, Toshiyuki Sakaki, Zai-Si Ji, Hiroshi Tsuboi, Junji Terao and Yoshichika Kawai :
Anti-inflammatory activity of quercetin and the conjugates at human plasma levels,
6th International conference on Food Factors (ICoFF2015), Nov. 2015.
12. Yoshichika Kawai :
Two distinct pathways for anti-inflammatory activity of quercetin conjugates,
6th International conference on Food Factors (ICoFF2015), Nov. 2015.
13. Yoshichika Kawai :
Dietary flavonoids induce autophagic degradation in macrophages,
7th International conference on Polyphenol and Health (ICPH), Oct. 2015.
14. Junji Terao and Yoshichika Kawai :
Possible riole of -(-) epicatehin gallate in antiatherosclerotic actions of tea catehins,
International Conference on Ocya Shizuoka, Shizuoka, Oct. 2010.
15. Junji Terao, Kaeko Murota and Yoshichika Kawai :
Flavonoid paradox between biological acitivity and bioavailability:insight into their delivery to the target site,
4th International conference on polyphenols and health, Harrogate,UK, Dec. 2009.
16. Junji Terao, Kaeko Murota and Yoshichika Kawai :
Prevention of athrosclerosis by functional food factors,
Itary-Japan Symposium on Foods and, Tokyo, Oct. 2009.
17. Junji Terao and Yoshichika Kawai :
Mechanistic approach to anti-atherosclerotic effect of tea catechins,
2008 Internaitonal Symposium on Chronic Disease and LOHAS Foods, Jeju KOREA, Oct. 2008.
18. Junji Terao, Kaeko Murota and Yoshichika Kawai :
Antioxidative flavonoid quercetin:metabolic conversion behand its antiatheroslcerotic sffect,
International symposium on Lipid peroxidation 2008, Karuizawa, Oct. 2008.
19. Junji Terao, Kaeko Murota and Yoshichika Kawai :
Availability and behavior od dietary flavonoids in the target site,
2nd international symposium on translational research on natural produts and cancer, Lonavala, Mumbai, India, Dec. 2007.
20. Junji Terao, Kaeko Murota and Yoshichika Kawai :
Antioxidant activity and physiological significance of flavonoid metabolites,
The 9th International Conferecen on Mechanisms of antimutagenesis and anticarcinogenesis, Jeju Island, Korea, Dec. 2007.
21. Takashi Kinoshita, Zsolt Lepp, Yuko Shiba, Yoshichika Kawai, Junji Terao and Hiroshi Chuman :
Chemoinformatics and QSAR Study of Flavonoids,
Tokyo, Dec. 2007.
22. Junji Terao, Yoshichika Kawai and Kaeko Murota :
Vegetable flavonoids and cardiovascular disease,
10th _Asian Congress of Nutrition, Taipei, Sep. 2007.
23. Hiroyuki Sakakibara, Yuki Izawa, Jun-ichiro Nakajima, Shujiro Seo, Toshiaki Tamaki, Yoshichika Kawai and Junji Terao :
Antidepressant effects of polyphenol rich herbal medicine, Ginkgo biloba, extracts in behavioral models,
232 nd American Chemical Society Meeting & Exposition, San Francisco, Sep. 2006.
24. Junji Terao and Yoshichika Kawai :
Accumulation of antioxidative flavonoids in the target site,
SFRR's 13th Biennial Meeting, Davos, Switzerland, Aug. 2006.
25. Hiroyuki Sakakibara, Kaori Ishida, Yuki Izawa, Yuko Minami, Satomi Saito, Yoshichika Kawai, Butterweck Veronika, Toshiaki Tamaki, Yutaka Nakaya and Junji Terao :
Effects of Ginkgo biloba Extract on Rat brain Function,
2nd International Conference on Polyphenols and Health, California Davis, Davis, Oct. 2005.
26. Hiroyuki Sakakibara, Kaori Ishida, Yuki Izawa, Yuko Minami, Saito Saromi, Yoshichika Kawai, Butterweck Veronika, Toshiaki Tamaki, Yutaka Nakaya and Junji Terao :
Effects of forced swimming stress on rat brain function,
2005 COE International Conference ''Biological Mechanism for Stress Control'', Tokushima, Aug. 2005.

Proceeding of Domestic Conference:

1. Moe Fujimoto, Kohta Ohnishi, Maiko Sakai, Teppei Fukuda, Aika Ohnishi, Masashi Masuda, Hisami Okumura, Yoshichika Kawai and Yutaka Taketani :
Exploration of bioactive food factors for the control of autophagy flux,
日本農芸化学会2019年度大会, Mar. 2019.
2. Maiko Sakai, Kohta Ohnishi and Yoshichika Kawai :
イソラムネチンはmTORC2シグナル依存的にマクロファージ様細胞におけるリソソーム活性を亢進する,
第23回日本フードファクター学会学術集会, Sep. 2018.
3. 吉田 里沙, Masashi Masuda, 森 優樹, 新井田 裕樹, 足立 雄一郎, Kohta Ohnishi, Yoshichika Kawai, Takeshi Nikawa, 山本 浩範 and Yutaka Taketani :
スルフォラファンのリポファジーを介した脂肪分解効果,
Food Congress 2018, Sep. 2018.
4. Yuuki Niida, Masashi Masuda, Aika Yoshizawa, Yuichiroh Adachi, Takayuki Uchida, Kohta Ohnishi, Yoshichika Kawai, Takeshi Nikawa, Hironori Yamamoto and Yutaka Taketani :
慢性腎臓病に伴う骨格筋の飽和脂肪酸蓄積はオートファジー不全を介して筋萎縮を誘発する,
日本ビタミン学会第70回大会(高槻現代劇場), Jun. 2018.
5. Saya Okamoto, Maya Daioku, Kohta Ohnishi and Yoshichika Kawai :
一重項酸素によって生じるリノール酸10-/12-リノール酸ヒドロペルオキシド異性体の単離とその分解物の探索,
第71回日本酸化ストレス学会/第18回日本NO学会 合同学術集会, May 2018.
6. Risa Yoshida, Yuuki Niida, Yuichiroh Adachi, 酒井 晶子, Hisami Okumura, Kohta Ohnishi, Takayuki Uchida, Yoshichika Kawai, Hironori Yamamoto, Takeshi Nikawa, Yutaka Taketani and Masashi Masuda :
スルフォラファンのリポファジーを介した脂肪分解効果,
第72回日本栄養・食糧学会大会(岡山県立大学), May 2018.
7. Fukuda Taishi and Yoshichika Kawai :
Interaction of Quercetin Glucuronides with Macrophages and Its Contribution to Anti-inflammatory Activity,
第22回日本フードファクター学会(JSoFF), Dec. 2017.
8. Saito Hideki and Yoshichika Kawai :
Analysis of anti-inflammatory effect of polyphenols in grape beverages and identification of the active compounds,
第22回日本フードファクター学会(JSoFF), Dec. 2017.
9. Fukuda Taishi and Yoshichika Kawai :
マクロファージにおけるケルセチングルクロン酸抱合体の脱抱合と抗炎症活性,
日本農芸化学会関西・中四国・西日本支部2017年度合同支部大阪大会, Sep. 2017.
10. Arai Hikaru, Koike Taisuke and Yoshichika Kawai :
天然フラボノイド・タキシフォリンの化学的特性と生体利用性の解析,
日本農芸化学会中四国支部第48回講演会, Jun. 2017.
11. 新井田 祐樹, Masashi Masuda, 吉澤 和香, Yimamu Ilimulati, 吉田 里沙, 甲谷 芹奈, Hisami Okumura, Yoshichika Kawai, Yutaka Taketani and Hironori Yamamoto :
骨格筋脂質代謝異常が慢性腎臓病に伴うProtein Energy Wasting (CKD-PEW) を誘発する,
第71回 日本栄養・食糧学会大会, May 2017.
12. Naomi Kanoh, 國末 成美, 宗正 晋太郎, 村田 芳行, Yoshichika Kawai, 佐藤 あやの, 守屋 央朗 and 中村 宜督 :
食品成分ベンジルイソチオシアネートによる動原体を標的とした大腸がん細胞増殖阻害作用,
日本農芸化学会2017年度大会, Mar. 2017.
13. 額 惠理香, Kohta Ohnishi, Junji Terao and Yoshichika Kawai :
アデノシン類によるマクロファージ炎症促進作用に対するポリフェノールの効果,
日本農芸化学会2017年度大会, Mar. 2017.
14. 額 惠理香, Junji Terao and Yoshichika Kawai :
アデノシン類による炎症促進機構に対するポリフェノールの作用,
第21回日本フードファクター学会学術集会, Nov. 2016.
15. Hiroshi Tatano, Hisami Okumura, Daisuke Kajiura, 近藤 千佳, 平山 明由, Kazuaki Mawatari, Yoshichika Kawai, Masashi Masuda and Yutaka Taketani :
GC-MSを用いた肉の種類別の摂取バイオマーカーの探索,
第10回メタボロームシンポジウム, Oct. 2016.
16. 齋藤 豪紀 and Yoshichika Kawai :
ブドウ飲料中に含まれるポリフェノールの抗炎症作用の解析,
日本農芸化学会2016年度中四国支部大会, Sep. 2016.
17. 額 惠理香, Junji Terao and Yoshichika Kawai :
アデノシン類による炎症促進機構に対するポリフェノールの作用,
第22回フードサイエンスフォーラム学術集会, Sep. 2016.
18. 額惠 理香, 大西 康太, Junji Terao and Yoshichika Kawai :
アデノシン類が促進するマクロファージ炎症応答に対する食品由来ポリフェノールの作用,
第70回日本栄養・食糧学会大会, May 2016.
19. Rie Mukai, 鈴木 里穂, 田中 義章, 嶺川 祥子, Yoshichika Kawai and Junji Terao :
ケルセチン抱合体代謝物に対する腎臓の脱抱合化反応の解析,
日本農芸化学会2016年度大会, Mar. 2015.
20. Rie Mukai, 水口 八重子, 藤倉 温, 河野 尚平, Takeshi Nikawa, Yoshichika Kawai and Junji Terao :
ケルセチンの経口摂取による廃用性筋萎縮予防の可能性,
第65回日本栄養・食糧学会大会, May 2011.
21. Rie Mukai, 水口 八重子, 藤倉 温, 河村 知志, Hisao Nemoto, Yoshichika Kawai, Junji Terao and 侯 徳興 :
プレニル化ケルセチンの筋萎縮予防効果とその特徴,
日本農芸学会, Mar. 2011.
22. 廣隅 公治, 馬島 彬, Tatsusada Yoshida, 志葉 優子, Yoshichika Kawai, Junji Terao and Hiroshi Chuman :
非経験的分子軌道法によるフェノール水素原子のラジカル引き抜き反応の分子論的考察およびフラボノイドの構造活性相関への応用,
第38回構造活性相関シンポジウム, 72-74, Oct. 2010.
23. Rie Mukai, 大塚 聖子, 川畑 球一, 石坂 朱里, Yoshichika Kawai and Junji Terao :
神経細胞において誘導される酸化ストレスに対するケルセチンの作用,
第64回日本栄養・食糧学会大会, May 2010.
24. Koji Hirozumi, Tatsusada Yoshida, Yoshichika Kawai, Junji Terao and Hiroshi Chuman :
QSAR of DPPH Activity of Flavonoids Based on Ab Initio MO Studies of Hydrogen Radical Abstraction of Phenols,
第37回構造活性相関シンポジウム, Nov. 2009.
25. Takashi Kinoshita, Zsolt Lepp, Yoshichika Kawai, Junji Terao and Hiroshi Chuman :
An Integrated Database of Flavonoides,
CBI学会2007年大会, Oct. 2007.

Et cetera, Workshop:

1. Maiko Sakai, Kohta Ohnishi and Yoshichika Kawai :
マクロファージのリソソーム活性を亢進する食品成分の探索と作用機序の解析,
第257回徳島医学会学術集会(平成30年度夏期), Aug. 2018.

Patent:

1. Yoshichika Kawai and Junji Terao : 抗ケルセチンモノクローナル抗体,その産生細胞,ケルセチンの検出方法及び検出試薬, (Oct. 2005), 2005-298972.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • Study on biological activity of food-derived nucleic acids in intestinal immune system (Project/Area Number: 15K14730 )
  • Study on the interaction between target cells and polyphenol conjugates underlying the molecular mechanism of their biological activity (Project/Area Number: 26292069 )
  • Evaluation of inflammatory responses by mitochondrial DNA adducts (Project/Area Number: 25660103 )
  • Screening of food factors that target the quality control system of mitochondria (Project/Area Number: 23658118 )
  • Evaluatuion ofstress-inducedactivation of quercetinand its multifunctional dynamics (Project/Area Number: 22380077 )
  • Study for target molecules of poIyphenoIs to evaluate their functions and safety. (Project/Area Number: 19688007 )
  • Relationship between metabolic conversion of dietary flavonoids and their functions on oxidative stress (Project/Area Number: 19380075 )
  • 食品の抗酸化機能評価を目指した酸化ストレス産物の一斉解析法の開発 (Project/Area Number: 17780104 )
  • 食品の酸化ストレス制御機能評価をめざしたパーオキシリピドーム解析 (Project/Area Number: 16658057 )
  • Accumulation and Metabolism of Antioxidative Flavonoids on Oxidative Stress-Targeted Organs and Expression Mechanism of Their Activity (Project/Area Number: 16380089 )
  • Search by Researcher Number (50380027)