{"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/118784","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/38041484","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=404182","label":"url"}],"paper_title":{"en":"Seven-plus hours of daily sedentary time and the subsequent risk of breast cancer: Japan Multi-Institutional Collaborative Cohort Study.","ja":"Seven-plus hours of daily sedentary time and the subsequent risk of breast cancer: Japan Multi-Institutional Collaborative Cohort Study."},"authors":{"en":[{"name":"Tomida Satomi"},{"name":"Koyama Teruhide"},{"name":"Ozaki Etsuko"},{"name":"Takashima Naoyuki"},{"name":"Morita Midori"},{"name":"Sakaguchi Koichi"},{"name":"Naoi Yasuto"},{"name":"Nishida Yuichiro"},{"name":"Hara Megumi"},{"name":"Hishida Asahi"},{"name":"Tamura Takashi"},{"name":"Okada Rieko"},{"name":"Kubo Yoko"},{"name":"Otonari Jun"},{"name":"Ikezaki Hiroaki"},{"name":"Nakamura Yohko"},{"name":"Kusakabe Miho"},{"name":"Tanoue Shiroh"},{"name":"Koriyama Chihaya"},{"name":"Koyanagi Yuriko N"},{"name":"Ito Hidemi"},{"name":"Suzuki Sadao"},{"name":"Otani Takahiro"},{"name":"Miyagawa Naoko"},{"name":"Okami Yukiko"},{"name":"Arisawa Kokichi"},{"name":"Watanabe Takeshi"},{"name":"Kuriki Kiyonori"},{"name":"Wakai Kenji"},{"name":"Matsuo Keitaro"}],"ja":[{"name":"Tomida Satomi"},{"name":"Koyama Teruhide"},{"name":"Ozaki Etsuko"},{"name":"Takashima Naoyuki"},{"name":"Morita Midori"},{"name":"Sakaguchi Koichi"},{"name":"Naoi Yasuto"},{"name":"Nishida Yuichiro"},{"name":"Hara Megumi"},{"name":"Hishida Asahi"},{"name":"Tamura Takashi"},{"name":"Okada Rieko"},{"name":"Kubo Yoko"},{"name":"Otonari Jun"},{"name":"Ikezaki Hiroaki"},{"name":"Nakamura Yohko"},{"name":"Kusakabe Miho"},{"name":"Tanoue Shiroh"},{"name":"Koriyama Chihaya"},{"name":"Koyanagi Yuriko N"},{"name":"Ito Hidemi"},{"name":"Suzuki Sadao"},{"name":"Otani Takahiro"},{"name":"Miyagawa Naoko"},{"name":"Okami Yukiko"},{"name":"有澤 孝吉"},{"name":"渡邊 毅"},{"name":"Kuriki Kiyonori"},{"name":"Wakai Kenji"},{"name":"Matsuo Keitaro"}]},"description":{"en":"This study aimed to investigate the association between daily sedentary time and the risk of breast cancer (BC) in a large Japanese population. The participants were 36,023 women aged 35-69years from the Japan Multi-Institutional Collaborative Cohort Study. Cox proportional hazards analysis was used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for BC incidence in relation to time spent sedentarily (categorical variables: <7 and 7hours/day [h/d]). Additionally, the associations of BC incidence to the joint effect of sedentary time with each component of physical activity, such as leisure-time metabolic equivalents (METs), frequency of leisure-time physical activity, and daily walking time, were examined. During 315,189 person-years of follow-up, 554 incident cases of BC were identified. When compared to participants who spent <7h/d sedentary, those who spent 7h/d sedentary have a significantly higher risk of BC (HR, 1.36; 95% CI, 1.07-1.71). The corresponding HRs among participants who spent 7h/d sedentary with more physical activity, such as 1h/d for leisure-time METs, 3days/week of leisure-time physical activity, and 1h/d of daily walking were 1.58 (95% CI, 1.11-2.25), 1.77 (95% CI, 1.20-2.61), and 1.42 (95% CI, 1.10-1.83), respectively, compared with those who spent <7h/d sedentary. This study found that spending 7h/d of sedentary time is associated with the risk of BC. Neither leisure-time physical activity nor walking had a BC-preventive effect in those with 7h/d of sedentary time.","ja":"This study aimed to investigate the association between daily sedentary time and the risk of breast cancer (BC) in a large Japanese population. The participants were 36,023 women aged 35-69years from the Japan Multi-Institutional Collaborative Cohort Study. Cox proportional hazards analysis was used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for BC incidence in relation to time spent sedentarily (categorical variables: <7 and 7hours/day [h/d]). Additionally, the associations of BC incidence to the joint effect of sedentary time with each component of physical activity, such as leisure-time metabolic equivalents (METs), frequency of leisure-time physical activity, and daily walking time, were examined. During 315,189 person-years of follow-up, 554 incident cases of BC were identified. When compared to participants who spent <7h/d sedentary, those who spent 7h/d sedentary have a significantly higher risk of BC (HR, 1.36; 95% CI, 1.07-1.71). The corresponding HRs among participants who spent 7h/d sedentary with more physical activity, such as 1h/d for leisure-time METs, 3days/week of leisure-time physical activity, and 1h/d of daily walking were 1.58 (95% CI, 1.11-2.25), 1.77 (95% CI, 1.20-2.61), and 1.42 (95% CI, 1.10-1.83), respectively, compared with those who spent <7h/d sedentary. This study found that spending 7h/d of sedentary time is associated with the risk of BC. Neither leisure-time physical activity nor walking had a BC-preventive effect in those with 7h/d of sedentary time."},"publication_date":"2023-12-02","publication_name":{"en":"Cancer Science","ja":"Cancer Science"},"languages":["eng"],"referee":true,"identifiers":{"doi":["10.1111/cas.16020"],"issn":["1349-7006"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/118729","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/37926519","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=403747","label":"url"}],"paper_title":{"en":"Association between awareness of limiting food intake and all-cause mortality: A cohort study in Japan","ja":"Association between awareness of limiting food intake and all-cause mortality: A cohort study in Japan"},"authors":{"en":[{"name":"Nishimoto Daisaku"},{"name":"Ibusuki Rie"},{"name":"Shimoshikiryo Ippei"},{"name":"Shibuya Kenichi"},{"name":"Tanoue Shiroh"},{"name":"Koriyama Chihaya"},{"name":"Takezaki Toshiro"},{"name":"Oze Isao"},{"name":"Ito Hidemi"},{"name":"Hishida Asahi"},{"name":"Tamura Takashi"},{"name":"Kato Yasufumi"},{"name":"Tamada Yudai"},{"name":"Nishida Yuichiro"},{"name":"Shimanoe Chisato"},{"name":"Suzuki Sadao"},{"name":"Nishiyama Takeshi"},{"name":"Ozaki Etsuko"},{"name":"Tomida Satomi"},{"name":"Kuriki Kiyonori"},{"name":"Miyagawa Naoko"},{"name":"Kondo Keiko"},{"name":"Arisawa Kokichi"},{"name":"Watanabe Takeshi"},{"name":"Ikezaki Hiroaki"},{"name":"Otonari Jun"},{"name":"Wakai Kenji"},{"name":"Matsuo Keitaro"}],"ja":[{"name":"Nishimoto Daisaku"},{"name":"Ibusuki Rie"},{"name":"Shimoshikiryo Ippei"},{"name":"Shibuya Kenichi"},{"name":"Tanoue Shiroh"},{"name":"Koriyama Chihaya"},{"name":"Takezaki Toshiro"},{"name":"Oze Isao"},{"name":"Ito Hidemi"},{"name":"Hishida Asahi"},{"name":"Tamura Takashi"},{"name":"Kato Yasufumi"},{"name":"Tamada Yudai"},{"name":"Nishida Yuichiro"},{"name":"Shimanoe Chisato"},{"name":"Suzuki Sadao"},{"name":"Nishiyama Takeshi"},{"name":"Ozaki Etsuko"},{"name":"Tomida Satomi"},{"name":"Kuriki Kiyonori"},{"name":"Miyagawa Naoko"},{"name":"Kondo Keiko"},{"name":"有澤 孝吉"},{"name":"渡邊 毅"},{"name":"Ikezaki Hiroaki"},{"name":"Otonari Jun"},{"name":"Wakai Kenji"},{"name":"Matsuo Keitaro"}]},"description":{"en":"Improving diets requires an awareness of the need to limit foods for which excessive consumption is a health problem. Since there are limited reports on the link between this awareness and mortality risk, we examined the association between awareness of limiting food intake (energy, fat, and sweets) and all-cause mortality in a Japanese cohort study. Participants comprised 58,772 residents (27,294 men; 31,478 women) aged 35-69 years who completed baseline surveys of the Japan Multi-Institutional Collaborative Cohort Study from 2004 to 2014. Hazard ratios (HRs) for all-cause mortality and 95% confidence intervals (CIs) were estimated by sex using a Cox proportional hazard model, with adjustment for related factors. Mediation analysis with fat intake as a mediator was also conducted. The mean follow-up period was 11 years and 2,516 people died. Estimated energy and fat intakes according to the Food Frequency Questionnaire were lower in those with awareness of limiting food intake than in those without this awareness. Women with awareness of limiting fat intake showed a significant decrease in mortality risk (HR=0.73; 95% CI, 0.55 to 0.94). Mediation analysis revealed that this association was due to the direct effect of the awareness of limiting fat intake and that the total effect was not mediated by actual fat intake. Awareness of limiting energy or sweets intake was not related to mortality risk reduction. Awareness of limiting food intake had a limited effect on reducing all-cause mortality risk.","ja":"Improving diets requires an awareness of the need to limit foods for which excessive consumption is a health problem. Since there are limited reports on the link between this awareness and mortality risk, we examined the association between awareness of limiting food intake (energy, fat, and sweets) and all-cause mortality in a Japanese cohort study. Participants comprised 58,772 residents (27,294 men; 31,478 women) aged 35-69 years who completed baseline surveys of the Japan Multi-Institutional Collaborative Cohort Study from 2004 to 2014. Hazard ratios (HRs) for all-cause mortality and 95% confidence intervals (CIs) were estimated by sex using a Cox proportional hazard model, with adjustment for related factors. Mediation analysis with fat intake as a mediator was also conducted. The mean follow-up period was 11 years and 2,516 people died. Estimated energy and fat intakes according to the Food Frequency Questionnaire were lower in those with awareness of limiting food intake than in those without this awareness. Women with awareness of limiting fat intake showed a significant decrease in mortality risk (HR=0.73; 95% CI, 0.55 to 0.94). Mediation analysis revealed that this association was due to the direct effect of the awareness of limiting fat intake and that the total effect was not mediated by actual fat intake. Awareness of limiting energy or sweets intake was not related to mortality risk reduction. Awareness of limiting food intake had a limited effect on reducing all-cause mortality risk."},"publication_date":"2023-11-04","publication_name":{"en":"Journal of Epidemiology","ja":"Journal of Epidemiology"},"languages":["eng"],"referee":true,"identifiers":{"doi":["10.2188/jea.JE20220354"],"issn":["1349-9092"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/37739810","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=403698","label":"url"}],"paper_title":{"en":"Prevalence, Clinical Profiles, and Prognosis of Stiff-Person Syndrome in a Japanese Nationwide Survey.","ja":"Prevalence, Clinical Profiles, and Prognosis of Stiff-Person Syndrome in a Japanese Nationwide Survey."},"authors":{"en":[{"name":"Matsui Naoko"},{"name":"Tanaka Keiko"},{"name":"Ishida Mitsuyo"},{"name":"Yamamoto Yohei"},{"name":"Matsubara Yuri"},{"name":"Saika Reiko"},{"name":"Iizuka Takahiro"},{"name":"Nakamura Koshi"},{"name":"Kuriyama Nagato"},{"name":"Matsui Makoto"},{"name":"Arisawa Kokichi"},{"name":"Nakamura Yosikazu"},{"name":"Kaji Ryuji"},{"name":"Kuwabara Satoshi"},{"name":"Izumi Yuishin"}],"ja":[{"name":"松井 尚子"},{"name":"Tanaka Keiko"},{"name":"Ishida Mitsuyo"},{"name":"Yamamoto Yohei"},{"name":"Matsubara Yuri"},{"name":"Saika Reiko"},{"name":"Iizuka Takahiro"},{"name":"Nakamura Koshi"},{"name":"Kuriyama Nagato"},{"name":"Matsui Makoto"},{"name":"有澤 孝吉"},{"name":"Nakamura Yosikazu"},{"name":"梶 龍兒"},{"name":"Kuwabara Satoshi"},{"name":"和泉 唯信"}]},"description":{"en":"This study provides the current epidemiologic and clinical status of SPS in Japan. The symptom onset to the diagnosis of SPS was longer in patients with high-titer GAD65 antibodies than in those with low-titer GAD65 antibodies. The outcome of patients with SPS was generally favorable, but more aggressive immunotherapies are necessary for GAD65-positive patients with SPS.","ja":"This study provides the current epidemiologic and clinical status of SPS in Japan. The symptom onset to the diagnosis of SPS was longer in patients with high-titer GAD65 antibodies than in those with low-titer GAD65 antibodies. The outcome of patients with SPS was generally favorable, but more aggressive immunotherapies are necessary for GAD65-positive patients with SPS."},"publication_date":"2023-09-22","publication_name":{"en":"Neurology® Neuroimmunology & Neuroinflammation","ja":"Neurology® Neuroimmunology & Neuroinflammation"},"volume":"Vol.10","number":"No.6","starting_page":"e200165","ending_page":"e200165","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1212/NXI.0000000000200165"],"issn":["2332-7812"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/37517992","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=399162","label":"url"}],"paper_title":{"en":"GWAS of folate metabolism with gene-environment interaction analysis revealed the possible role of lifestyles in the control of blood folate metabolites in Japanese - the J-MICC Study.","ja":"GWAS of folate metabolism with gene-environment interaction analysis revealed the possible role of lifestyles in the control of blood folate metabolites in Japanese - the J-MICC Study."},"authors":{"en":[{"name":"Tsukamoto Mineko"},{"name":"Hishida Asahi"},{"name":"Tamura Takashi"},{"name":"Nagayoshi Mako"},{"name":"Okada Rieko"},{"name":"Kubo Yoko"},{"name":"Kato Yasufumi"},{"name":"Hamajima Nobuyuki"},{"name":"Nishida Yuichiro"},{"name":"Shimanoe Chisato"},{"name":"Ibusuki Rie"},{"name":"Shibuya Kenichi"},{"name":"Takashima Naoyuki"},{"name":"Nakamura Yasuyuki"},{"name":"Kusakabe Miho"},{"name":"Nakamura Yohko"},{"name":"Koyanagi Yuriko N"},{"name":"Oze Isao"},{"name":"Nishiyama Takeshi"},{"name":"Suzuki Sadao"},{"name":"Watanabe Isao"},{"name":"Matsui Daisuke"},{"name":"Otonari Jun"},{"name":"Ikezaki Hiroaki"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Arisawa Kokichi"},{"name":"Kuriki Kiyonori"},{"name":"Nakatochi Masahiro"},{"name":"Momozawa Yukihide"},{"name":"Takeuchi Kenji"},{"name":"Wakai Kenji"},{"name":"Matsuo Keitaro"}],"ja":[{"name":"Tsukamoto Mineko"},{"name":"Hishida Asahi"},{"name":"Tamura Takashi"},{"name":"Nagayoshi Mako"},{"name":"Okada Rieko"},{"name":"Kubo Yoko"},{"name":"Kato Yasufumi"},{"name":"Hamajima Nobuyuki"},{"name":"Nishida Yuichiro"},{"name":"Shimanoe Chisato"},{"name":"Ibusuki Rie"},{"name":"Shibuya Kenichi"},{"name":"Takashima Naoyuki"},{"name":"Nakamura Yasuyuki"},{"name":"Kusakabe Miho"},{"name":"Nakamura Yohko"},{"name":"Koyanagi Yuriko N"},{"name":"Oze Isao"},{"name":"Nishiyama Takeshi"},{"name":"Suzuki Sadao"},{"name":"Watanabe Isao"},{"name":"Matsui Daisuke"},{"name":"Otonari Jun"},{"name":"Ikezaki Hiroaki"},{"name":"勝浦-釜野 桜子"},{"name":"有澤 孝吉"},{"name":"Kuriki Kiyonori"},{"name":"Nakatochi Masahiro"},{"name":"Momozawa Yukihide"},{"name":"Takeuchi Kenji"},{"name":"Wakai Kenji"},{"name":"Matsuo Keitaro"}]},"publication_date":"2023-07-29","publication_name":{"en":"Journal of Epidemiology","ja":"Journal of Epidemiology"},"languages":["eng"],"referee":true,"identifiers":{"doi":["10.2188/jea.JE20220341"],"issn":["1349-9092"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=395890","label":"url"}],"paper_title":{"en":"質問紙で調査した成人の身体活動:日本多施設共同コーホート研究(J-MICC Study)","ja":"質問紙で調査した成人の身体活動:日本多施設共同コーホート研究(J-MICC Study)"},"authors":{"en":[{"name":"齋藤 義信"},{"name":"小熊 祐子"},{"name":"中村 翔"},{"name":"成松 宏人"},{"name":"中嶋 綾子"},{"name":"池崎 裕昭"},{"name":"田中 恵太郎"},{"name":"原 めぐみ"},{"name":"玉田 雄大"},{"name":"永吉 真子"},{"name":"田村 高志"},{"name":"菱田 朝陽"},{"name":"尾瀬 功"},{"name":"谷山 祐香里"},{"name":"三上 春夫"},{"name":"永瀬 浩喜"},{"name":"嶽﨑 俊郎"},{"name":"指宿 りえ"},{"name":"鈴木 貞夫"},{"name":"大谷 隆浩"},{"name":"小山 晃英"},{"name":"渡邉 功"},{"name":"栗木 清典"},{"name":"喜多 義邦"},{"name":"高嶋 直敬"},{"name":"Arisawa Kokichi"},{"name":"Kamano Sakurako"},{"name":"竹内 研時"},{"name":"若井 建志"},{"name":".J-MICC研究グループ"}],"ja":[{"name":"齋藤 義信"},{"name":"小熊 祐子"},{"name":"中村 翔"},{"name":"成松 宏人"},{"name":"中嶋 綾子"},{"name":"池崎 裕昭"},{"name":"田中 恵太郎"},{"name":"原 めぐみ"},{"name":"玉田 雄大"},{"name":"永吉 真子"},{"name":"田村 高志"},{"name":"菱田 朝陽"},{"name":"尾瀬 功"},{"name":"谷山 祐香里"},{"name":"三上 春夫"},{"name":"永瀬 浩喜"},{"name":"嶽﨑 俊郎"},{"name":"指宿 りえ"},{"name":"鈴木 貞夫"},{"name":"大谷 隆浩"},{"name":"小山 晃英"},{"name":"渡邉 功"},{"name":"栗木 清典"},{"name":"喜多 義邦"},{"name":"高嶋 直敬"},{"name":"有澤 孝吉"},{"name":"釜野 桜子"},{"name":"竹内 研時"},{"name":"若井 建志"},{"name":".J-MICC研究グループ"}]},"publication_date":"2023-03","publication_name":{"en":"運動疫学研究","ja":"運動疫学研究"},"languages":["jpn"],"referee":true,"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/36710119","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=393376","label":"url"}],"paper_title":{"en":"Coffee and Metabolic Phenotypes: A Cross-sectional Analysis of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study","ja":"Coffee and Metabolic Phenotypes: A Cross-sectional Analysis of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study"},"authors":{"en":[{"name":"Watanabe Takeshi"},{"name":"Arisawa Kokichi"},{"name":"Nguyen Van Tien"},{"name":"Ishizu Masashi"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Hishida Asahi"},{"name":"Tamura Takashi"},{"name":"Kato Yasufumi"},{"name":"Okada Rieko"},{"name":"Ibusuki Rie"},{"name":"Koriyama Chihaya"},{"name":"Suzuki Sadao"},{"name":"Otani Takahiro"},{"name":"Koyama Teruhide"},{"name":"Tomida Satomi"},{"name":"Kuriki Kiyonori"},{"name":"Takashima Naoyuki"},{"name":"Miyagawa Naoko"},{"name":"Wakai Kenji"},{"name":"Matsuo Keitaro"}],"ja":[{"name":"渡邊 毅"},{"name":"有澤 孝吉"},{"name":"TIEN VAN NGUYEN"},{"name":"石津 将"},{"name":"勝浦-釜野 桜子"},{"name":"Hishida Asahi"},{"name":"Tamura Takashi"},{"name":"Kato Yasufumi"},{"name":"Okada Rieko"},{"name":"Ibusuki Rie"},{"name":"Koriyama Chihaya"},{"name":"Suzuki Sadao"},{"name":"Otani Takahiro"},{"name":"Koyama Teruhide"},{"name":"Tomida Satomi"},{"name":"Kuriki Kiyonori"},{"name":"Takashima Naoyuki"},{"name":"Miyagawa Naoko"},{"name":"Wakai Kenji"},{"name":"Matsuo Keitaro"}]},"description":{"en":"To date, the relationship between coffee consumption and metabolic phenotypes has hardly been investigated and remains controversial. Therefore, the aim of this cross-sectional study is to examine the associations between coffee consumption and metabolic phenotypes in a Japanese population. We analyzed the data of 26,363 subjects (aged 35-69 years) in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. Coffee consumption was assessed using a questionnaire. Metabolic Syndrome (MetS) was defined according to the Joint Interim Statement Criteria of 2009, using body mass index (BMI) instead of waist circumference. Subjects stratified by the presence or absence of obesity (normal weight: BMI <25 kg/m; obesity: BMI ≥25 kg/m) were classified by the number of MetS components (metabolically healthy: no components; metabolically unhealthy: one or more components) other than BMI. In multiple logistic regression analyses adjusted for sex, age, and other potential confounders, high coffee consumption (≥3 cups/day) was associated with a lower prevalence of MetS and metabolically unhealthy phenotypes both in normal weight (OR 0.83, 95% CI 0.76-0.90) and obese subjects (OR 0.83, 95% CI 0.69-0.99). Filtered/instant coffee consumption was inversely associated with the prevalence of MetS and metabolically unhealthy phenotypes, whereas canned/bottled/packed coffee consumption was not. The present results suggest that high coffee consumption, particularly filtered/instant coffee, is inversely associated with the prevalence of metabolically unhealthy phenotypes in both normal weight and obese Japanese adults.","ja":"To date, the relationship between coffee consumption and metabolic phenotypes has hardly been investigated and remains controversial. Therefore, the aim of this cross-sectional study is to examine the associations between coffee consumption and metabolic phenotypes in a Japanese population. We analyzed the data of 26,363 subjects (aged 35-69 years) in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. Coffee consumption was assessed using a questionnaire. Metabolic Syndrome (MetS) was defined according to the Joint Interim Statement Criteria of 2009, using body mass index (BMI) instead of waist circumference. Subjects stratified by the presence or absence of obesity (normal weight: BMI <25 kg/m; obesity: BMI ≥25 kg/m) were classified by the number of MetS components (metabolically healthy: no components; metabolically unhealthy: one or more components) other than BMI. In multiple logistic regression analyses adjusted for sex, age, and other potential confounders, high coffee consumption (≥3 cups/day) was associated with a lower prevalence of MetS and metabolically unhealthy phenotypes both in normal weight (OR 0.83, 95% CI 0.76-0.90) and obese subjects (OR 0.83, 95% CI 0.69-0.99). Filtered/instant coffee consumption was inversely associated with the prevalence of MetS and metabolically unhealthy phenotypes, whereas canned/bottled/packed coffee consumption was not. The present results suggest that high coffee consumption, particularly filtered/instant coffee, is inversely associated with the prevalence of metabolically unhealthy phenotypes in both normal weight and obese Japanese adults."},"publication_date":"2023-03","publication_name":{"en":"Nutrition, Metabolism, and Cardiovascular Diseases : NMCD","ja":"Nutrition, Metabolism, and Cardiovascular Diseases : NMCD"},"volume":"Vol.33","number":"No.3","starting_page":"620","ending_page":"630","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.numecd.2022.12.019"],"issn":["1590-3729"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/36725019","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=393188","label":"url"}],"paper_title":{"en":"Association between dietary patterns and serum low density lipoprotein cholesterol in Japanese women and men: The Japan Multi-Institutional Collaborative Cohort (J-MICC) Study","ja":"Association between dietary patterns and serum low density lipoprotein cholesterol in Japanese women and men: The Japan Multi-Institutional Collaborative Cohort (J-MICC) Study"},"authors":{"en":[{"name":"Kitaoka Kaori"},{"name":"Miura Katsuyuki"},{"name":"Takashima Naoyuki"},{"name":"Kadota Aya"},{"name":"Harada Akiko"},{"name":"Nakamura Yasuyuki"},{"name":"Kita Yoshikuni"},{"name":"Yano Yuichiro"},{"name":"Tamura Takashi"},{"name":"Nagayoshi Mako"},{"name":"Okada Rieko"},{"name":"Kubo Yoko"},{"name":"Suzuki Sadao"},{"name":"Nishiyama Takeshi"},{"name":"Tanoue Shiroh"},{"name":"Koriyama Chihaya"},{"name":"Kuriki Kiyonori"},{"name":"Arisawa Kokichi"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Nishida Yuichiro"},{"name":"Shimanoe Chisato"},{"name":"Ozaki Etsuko"},{"name":"Matsui Daisuke"},{"name":"Ikezaki Hiroaki"},{"name":"Otonari Jun"},{"name":"Oze Isao"},{"name":"Koyanagi N. Yuriko"},{"name":"Nakamura Yohko"},{"name":"Kusakabe Miho"},{"name":"Wakai Kenji"},{"name":"Matsuo Keitaro"}],"ja":[{"name":"Kitaoka Kaori"},{"name":"Miura Katsuyuki"},{"name":"Takashima Naoyuki"},{"name":"Kadota Aya"},{"name":"Harada Akiko"},{"name":"Nakamura Yasuyuki"},{"name":"Kita Yoshikuni"},{"name":"Yano Yuichiro"},{"name":"Tamura Takashi"},{"name":"Nagayoshi Mako"},{"name":"Okada Rieko"},{"name":"Kubo Yoko"},{"name":"Suzuki Sadao"},{"name":"Nishiyama Takeshi"},{"name":"Tanoue Shiroh"},{"name":"Koriyama Chihaya"},{"name":"Kuriki Kiyonori"},{"name":"有澤 孝吉"},{"name":"勝浦-釜野 桜子"},{"name":"Nishida Yuichiro"},{"name":"Shimanoe Chisato"},{"name":"Ozaki Etsuko"},{"name":"Matsui Daisuke"},{"name":"Ikezaki Hiroaki"},{"name":"Otonari Jun"},{"name":"Oze Isao"},{"name":"Koyanagi N. Yuriko"},{"name":"Nakamura Yohko"},{"name":"Kusakabe Miho"},{"name":"Wakai Kenji"},{"name":"Matsuo Keitaro"}]},"description":{"en":"The association between dietary patterns and serum low density lipoprotein (LDL) cholesterol would be changing in recent dietary habits in Japan. We investigated the relationship between dietary patterns and serum LDL cholesterol in a large general population. From the baseline survey of Japan Multi-Institutional Collaborative Cohort Study between 2005 and 2013, 27,237 participants (13,994 were women) aged 35-69 years were cross-sectionally analyzed. Using a semi-quantitative food frequency questionnaire, five major sex-specific dietary patterns were identified using factor analysis. We assessed serum LDL cholesterol by quintiles of dietary pattern factor score. We identified dietary patterns; \"vegetable rich pattern\" , \"meat and fried food rich pattern\" and \"high bread and low rice pattern\" in women and men; \"fish and shellfish rich pattern\" and \"high confectioneries and low alcohol pattern\" in men; \"healthy Japanese diet pattern\" and \"high alcohol and low rice pattern\" in women. Serum LDL cholesterol in men was associated with \"high bread and low rice pattern\" score (Q5 was 4.2 mg/dL higher than Q1, p for trend <0.001) and \"high confectioneries and low alcohol pattern\" scores (Q5 was 9.5 mg/dL higher than Q1, p for trend <0.001). In women, serum LDL cholesterol was associated with \"high bread and low rice pattern\" score (Q5 was 7.1 mg/dL higher than Q1, p for trend <0.001). Some recent dietary patterns in Japan were associated with serum LDL cholesterol. Serum LDL cholesterol was associated with high bread and low rice pattern in both sex, and high confectioneries and low alcohol pattern in men.","ja":"The association between dietary patterns and serum low density lipoprotein (LDL) cholesterol would be changing in recent dietary habits in Japan. We investigated the relationship between dietary patterns and serum LDL cholesterol in a large general population. From the baseline survey of Japan Multi-Institutional Collaborative Cohort Study between 2005 and 2013, 27,237 participants (13,994 were women) aged 35-69 years were cross-sectionally analyzed. Using a semi-quantitative food frequency questionnaire, five major sex-specific dietary patterns were identified using factor analysis. We assessed serum LDL cholesterol by quintiles of dietary pattern factor score. We identified dietary patterns; \"vegetable rich pattern\" , \"meat and fried food rich pattern\" and \"high bread and low rice pattern\" in women and men; \"fish and shellfish rich pattern\" and \"high confectioneries and low alcohol pattern\" in men; \"healthy Japanese diet pattern\" and \"high alcohol and low rice pattern\" in women. Serum LDL cholesterol in men was associated with \"high bread and low rice pattern\" score (Q5 was 4.2 mg/dL higher than Q1, p for trend <0.001) and \"high confectioneries and low alcohol pattern\" scores (Q5 was 9.5 mg/dL higher than Q1, p for trend <0.001). In women, serum LDL cholesterol was associated with \"high bread and low rice pattern\" score (Q5 was 7.1 mg/dL higher than Q1, p for trend <0.001). Some recent dietary patterns in Japan were associated with serum LDL cholesterol. Serum LDL cholesterol was associated with high bread and low rice pattern in both sex, and high confectioneries and low alcohol pattern in men."},"publication_date":"2023-02-02","publication_name":{"en":"Journal of Atherosclerosis and Thrombosis","ja":"Journal of Atherosclerosis and Thrombosis"},"languages":["eng"],"referee":true,"identifiers":{"doi":["10.5551/jat.63675"],"issn":["1880-3873"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/36753494","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=393865","label":"url"}],"paper_title":{"en":"Effects of gene-lifestyle interactions on obesity based on a multi-locus risk score: a cross-sectional analysis","ja":"Effects of gene-lifestyle interactions on obesity based on a multi-locus risk score: a cross-sectional analysis"},"authors":{"en":[{"name":"Nakamura Sho"},{"name":"Fang Xuemin"},{"name":"Saito Yoshinobu"},{"name":"Narimatsu Hiroto"},{"name":"Ota Azusa"},{"name":"Ikezaki Hiroaki"},{"name":"Shimanoe Chisato"},{"name":"Tanaka Keitaro"},{"name":"Kubo Yoko"},{"name":"Tsukamoto Mineko"},{"name":"Tamura Takashi"},{"name":"Hishida Asahi"},{"name":"Oze Isao"},{"name":"Koyanagi N. Yuriko"},{"name":"Nakamura Yohko"},{"name":"Kusakabe Miho"},{"name":"Takezaki Toshiro"},{"name":"Nishimoto Daisaku"},{"name":"Suzuki Sadao"},{"name":"Otani Takahiro"},{"name":"Kuriyama Nagato"},{"name":"Matsui Daisuke"},{"name":"Kuriki Kiyonori"},{"name":"Kadota Aya"},{"name":"Nakamura Yasuyuki"},{"name":"Arisawa Kokichi"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Nakatochi Masahiro"},{"name":"Momozawa Yukihide"},{"name":"Kubo Michiaki"},{"name":"Takeuchi Kenji"},{"name":"Wakai Kenji"}],"ja":[{"name":"Nakamura Sho"},{"name":"Fang Xuemin"},{"name":"Saito Yoshinobu"},{"name":"Narimatsu Hiroto"},{"name":"Ota Azusa"},{"name":"Ikezaki Hiroaki"},{"name":"Shimanoe Chisato"},{"name":"Tanaka Keitaro"},{"name":"Kubo Yoko"},{"name":"Tsukamoto Mineko"},{"name":"Tamura Takashi"},{"name":"Hishida Asahi"},{"name":"Oze Isao"},{"name":"Koyanagi N. Yuriko"},{"name":"Nakamura Yohko"},{"name":"Kusakabe Miho"},{"name":"Takezaki Toshiro"},{"name":"Nishimoto Daisaku"},{"name":"Suzuki Sadao"},{"name":"Otani Takahiro"},{"name":"Kuriyama Nagato"},{"name":"Matsui Daisuke"},{"name":"Kuriki Kiyonori"},{"name":"Kadota Aya"},{"name":"Nakamura Yasuyuki"},{"name":"有澤 孝吉"},{"name":"勝浦-釜野 桜子"},{"name":"Nakatochi Masahiro"},{"name":"Momozawa Yukihide"},{"name":"Kubo Michiaki"},{"name":"Takeuchi Kenji"},{"name":"Wakai Kenji"}]},"description":{"en":"The relationship between lifestyle and obesity is a major focus of research. Personalized nutrition, which utilizes evidence from nutrigenomics, such as gene-environment interactions, has been attracting attention in recent years. However, evidence for gene-environment interactions that can inform treatment strategies is lacking, despite some reported interactions involving dietary intake or physical activity. Utilizing gene-lifestyle interactions in practice could aid in optimizing interventions according to genetic risk. This study aimed to elucidate the effects of gene-lifestyle interactions on body mass index (BMI). Cross-sectional data from the Japan Multi-Institutional Collaborative Cohort Study were used. Interactions between a multi-locus genetic risk score (GRS), calculated from 76 ancestry-specific single nucleotide polymorphisms, and nutritional intake or physical activity were assessed using a linear mixed-effect model. The mean (standard deviation) BMI and GRS for all participants (n = 12,918) were 22.9 (3.0) kg/m2 and -0.07 (0.16), respectively. The correlation between GRS and BMI was r(12,916) = 0.13 (95% confidence interval [CI] 0.11-0.15, P < 0.001). An interaction between GRS and saturated fatty acid intake was observed (β = -0.11, 95% CI -0.21 to -0.02). An interaction between GRS and n-3 polyunsaturated fatty acids was also observed in the females with normal-weight subgroup (β = -0.12, 95% CI -0.22 to -0.03). Our results provide evidence of an interaction effect between GRS and nutritional intake and physical activity. This gene-lifestyle interaction provides a basis for developing prevention or treatment interventions for obesity according to individual genetic predisposition.","ja":"The relationship between lifestyle and obesity is a major focus of research. Personalized nutrition, which utilizes evidence from nutrigenomics, such as gene-environment interactions, has been attracting attention in recent years. However, evidence for gene-environment interactions that can inform treatment strategies is lacking, despite some reported interactions involving dietary intake or physical activity. Utilizing gene-lifestyle interactions in practice could aid in optimizing interventions according to genetic risk. This study aimed to elucidate the effects of gene-lifestyle interactions on body mass index (BMI). Cross-sectional data from the Japan Multi-Institutional Collaborative Cohort Study were used. Interactions between a multi-locus genetic risk score (GRS), calculated from 76 ancestry-specific single nucleotide polymorphisms, and nutritional intake or physical activity were assessed using a linear mixed-effect model. The mean (standard deviation) BMI and GRS for all participants (n = 12,918) were 22.9 (3.0) kg/m2 and -0.07 (0.16), respectively. The correlation between GRS and BMI was r(12,916) = 0.13 (95% confidence interval [CI] 0.11-0.15, P < 0.001). An interaction between GRS and saturated fatty acid intake was observed (β = -0.11, 95% CI -0.21 to -0.02). An interaction between GRS and n-3 polyunsaturated fatty acids was also observed in the females with normal-weight subgroup (β = -0.12, 95% CI -0.22 to -0.03). Our results provide evidence of an interaction effect between GRS and nutritional intake and physical activity. This gene-lifestyle interaction provides a basis for developing prevention or treatment interventions for obesity according to individual genetic predisposition."},"publication_date":"2023-01-30","publication_name":{"en":"PLoS ONE","ja":"PLoS ONE"},"volume":"Vol.18","number":"No.2","starting_page":"e0279169","ending_page":"e0279169","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1371/journal.pone.0279169"],"issn":["1932-6203"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/36709979","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=393548","label":"url"}],"paper_title":{"en":"BMI and cardiometabolic traits in Japanese: a Mendelian randomization study","ja":"BMI and cardiometabolic traits in Japanese: a Mendelian randomization study"},"authors":{"en":[{"name":"Nagayoshi Mako"},{"name":"Hishida Asahi"},{"name":"Shimizu Tomonori"},{"name":"Kato Yasufumi"},{"name":"Kubo Yoko"},{"name":"Okada Rieko"},{"name":"Tamura Takashi"},{"name":"Otonari Jun"},{"name":"Ikezaki Hiroaki"},{"name":"Hara Megumi"},{"name":"Nishida Yuichiro"},{"name":"Oze Isao"},{"name":"Koyanagi N. Yuriko"},{"name":"Nakamura Yohko"},{"name":"Kusakabe Miho"},{"name":"Ibusuki Rie"},{"name":"Shibuya Keiichi"},{"name":"Suzuki Sadao"},{"name":"Nishiyama Takeshi"},{"name":"Koyama Teruhide"},{"name":"Ozaki Etsuko"},{"name":"Kuriki Kiyonori"},{"name":"Takashima Naoyuki"},{"name":"Nakamura Yasuyuki"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Arisawa Kokichi"},{"name":"Nakatochi Masahiro"},{"name":"Momozawa Yukihide"},{"name":"Takeuchi Kenji"},{"name":"Wakai Kenji"}],"ja":[{"name":"Nagayoshi Mako"},{"name":"Hishida Asahi"},{"name":"Shimizu Tomonori"},{"name":"Kato Yasufumi"},{"name":"Kubo Yoko"},{"name":"Okada Rieko"},{"name":"Tamura Takashi"},{"name":"Otonari Jun"},{"name":"Ikezaki Hiroaki"},{"name":"Hara Megumi"},{"name":"Nishida Yuichiro"},{"name":"Oze Isao"},{"name":"Koyanagi N. Yuriko"},{"name":"Nakamura Yohko"},{"name":"Kusakabe Miho"},{"name":"Ibusuki Rie"},{"name":"Shibuya Keiichi"},{"name":"Suzuki Sadao"},{"name":"Nishiyama Takeshi"},{"name":"Koyama Teruhide"},{"name":"Ozaki Etsuko"},{"name":"Kuriki Kiyonori"},{"name":"Takashima Naoyuki"},{"name":"Nakamura Yasuyuki"},{"name":"勝浦-釜野 桜子"},{"name":"有澤 孝吉"},{"name":"Nakatochi Masahiro"},{"name":"Momozawa Yukihide"},{"name":"Takeuchi Kenji"},{"name":"Wakai Kenji"}]},"description":{"en":"Although many observational studies have demonstrated significant relationships between obesity and cardiometabolic traits, the causality of these relationships in East Asians remains to be elucidated. We conducted individual-level Mendelian randomization (MR) analyses targeting 14,083 participants in the Japan Multi-Institutional Collaborative Cohort Study, and two-sample MR analyses using summary statistics based on genome-wide association study data from 173,430 Japanese. Using 83 body mass index-related loci, genetic risk scores (GRS) for BMI were calculated, and the effects of BMI on cardiometabolic traits were examined for individual-level MR analyses by the two-stage least squares estimator method. The β-coefficients and standard errors for the per-allele association of each single-nucleotide polymorphism as well as all outcomes, or odds ratios with 95% confidence intervals were calculated in the two-sample MR analyses. In individual-level MR analyses, the GRS of BMI was not significantly associated with any cardiometabolic traits. In two-sample MR analyses, higher BMI was associated with higher risks of higher blood pressure, triglycerides, uric acid, lower high-density-lipoprotein cholesterol and eGFR. The associations of BMI with type 2 diabetes in two-sample MR analyses were inconsistent by different methods, including the directions. The results of this study suggest that, even among the Japanese, an East Asian population with low levels of obesity, higher BMI could be causally associated with the development of a variety of cardiometabolic traits. Causality in those associations should be clarified in future studies with larger populations, especially those of BMI with type 2 diabetes.","ja":"Although many observational studies have demonstrated significant relationships between obesity and cardiometabolic traits, the causality of these relationships in East Asians remains to be elucidated. We conducted individual-level Mendelian randomization (MR) analyses targeting 14,083 participants in the Japan Multi-Institutional Collaborative Cohort Study, and two-sample MR analyses using summary statistics based on genome-wide association study data from 173,430 Japanese. Using 83 body mass index-related loci, genetic risk scores (GRS) for BMI were calculated, and the effects of BMI on cardiometabolic traits were examined for individual-level MR analyses by the two-stage least squares estimator method. The β-coefficients and standard errors for the per-allele association of each single-nucleotide polymorphism as well as all outcomes, or odds ratios with 95% confidence intervals were calculated in the two-sample MR analyses. In individual-level MR analyses, the GRS of BMI was not significantly associated with any cardiometabolic traits. In two-sample MR analyses, higher BMI was associated with higher risks of higher blood pressure, triglycerides, uric acid, lower high-density-lipoprotein cholesterol and eGFR. The associations of BMI with type 2 diabetes in two-sample MR analyses were inconsistent by different methods, including the directions. The results of this study suggest that, even among the Japanese, an East Asian population with low levels of obesity, higher BMI could be causally associated with the development of a variety of cardiometabolic traits. Causality in those associations should be clarified in future studies with larger populations, especially those of BMI with type 2 diabetes."},"publication_date":"2022-12-28","publication_name":{"en":"Journal of Epidemiology","ja":"Journal of Epidemiology"},"languages":["eng"],"referee":true,"identifiers":{"doi":["10.2188/jea.JE20220154"],"issn":["1349-9092"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/36240602","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=392785","label":"url"}],"paper_title":{"en":"Sex- and age-specific all-cause mortality in insomnia with hypnotics: Findings from Japan multi-institutional Collaborative Cohort Study.","ja":"Sex- and age-specific all-cause mortality in insomnia with hypnotics: Findings from Japan multi-institutional Collaborative Cohort Study."},"authors":{"en":[{"name":"Sogawa Rintaro"},{"name":"Shimanoe Chisato"},{"name":"Tanaka Keitaro"},{"name":"Hara Megumi"},{"name":"Nishida Yuichiro"},{"name":"Furukawa Takuma"},{"name":"Nagayoshi Mako"},{"name":"Hishida Asahi"},{"name":"Kubo Yoko"},{"name":"Kato Yasufumi"},{"name":"Oze Isao"},{"name":"Ito Hidemi"},{"name":"Nakamura Yohko"},{"name":"Kusakabe Miho"},{"name":"Tanoue Shiroh"},{"name":"Koriyama Chihaya"},{"name":"Suzuki Sadao"},{"name":"Otani Takahiro"},{"name":"Matsui Daisuke"},{"name":"Watanabe Isao"},{"name":"Kuriki Kiyonori"},{"name":"Takashima Naoyuki"},{"name":"Kadota Aya"},{"name":"Watanabe Takeshi"},{"name":"Arisawa Kokichi"},{"name":"Ikezaki Hiroaki"},{"name":"Otonari Jun"},{"name":"Wakai Kenji"},{"name":"Matsuo Keitaro"}],"ja":[{"name":"Sogawa Rintaro"},{"name":"Shimanoe Chisato"},{"name":"Tanaka Keitaro"},{"name":"Hara Megumi"},{"name":"Nishida Yuichiro"},{"name":"Furukawa Takuma"},{"name":"Nagayoshi Mako"},{"name":"Hishida Asahi"},{"name":"Kubo Yoko"},{"name":"Kato Yasufumi"},{"name":"Oze Isao"},{"name":"Ito Hidemi"},{"name":"Nakamura Yohko"},{"name":"Kusakabe Miho"},{"name":"Tanoue Shiroh"},{"name":"Koriyama Chihaya"},{"name":"Suzuki Sadao"},{"name":"Otani Takahiro"},{"name":"Matsui Daisuke"},{"name":"Watanabe Isao"},{"name":"Kuriki Kiyonori"},{"name":"Takashima Naoyuki"},{"name":"Kadota Aya"},{"name":"渡邊 毅"},{"name":"有澤 孝吉"},{"name":"Ikezaki Hiroaki"},{"name":"Otonari Jun"},{"name":"Wakai Kenji"},{"name":"Matsuo Keitaro"}]},"description":{"en":"Our study revealed sex-age specific associations between hypnotic use and all-cause mortality.","ja":"During the follow-up (mean, 8.4 ± 2.5 years), 1,492 mortalities were recorded, and the prevalence of taking hypnotics was 4.2%. Hypnotic use was associated with significantly greater risk of all-cause mortality, even after adjustment for the covariates (HR, 1.32; 95% CI, 1.07-1.63). The association between hypnotic use and all-cause mortality was robust in males (HR, 1.51; 95% CI, 1.15-1.96), and participants aged <60 years (HR, 1.75; 95% CI, 1.21-2.54)."},"publication_date":"2022-09-28","publication_name":{"en":"Sleep Medicine","ja":"Sleep Medicine"},"volume":"Vol.100","starting_page":"410","ending_page":"418","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.sleep.2022.09.020"],"issn":["1878-5506"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/36162535","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=393995","label":"url"}],"paper_title":{"en":"Association Between Glycemic Traits and Primary Open-Angle Glaucoma: A Mendelian Randomization Study in the Japanese Population","ja":"Association Between Glycemic Traits and Primary Open-Angle Glaucoma: A Mendelian Randomization Study in the Japanese Population"},"authors":{"en":[{"name":"Hanyuda Akiko"},{"name":"Goto Atsushi"},{"name":"Nakatochi Masahiro"},{"name":"Sutoh Yoichi"},{"name":"Narita Akira"},{"name":"Nakano Shiori"},{"name":"Katagiri Ryoko"},{"name":"Wakai Kenji"},{"name":"Takashima Naoyuki"},{"name":"Koyama Teruhide"},{"name":"Arisawa Kokichi"},{"name":"Imoto Issei"},{"name":"Momozawa Yukihide"},{"name":"Tanno Kozo"},{"name":"Shimizu Atsushi"},{"name":"Hozawa Atsushi"},{"name":"Kinoshita Kengo"},{"name":"Yamaji Taiki"},{"name":"Sawada Norie"},{"name":"Iwagami Masao"},{"name":"Yuki Kenya"},{"name":"Tsubota Kazuo"},{"name":"Negishi Kazuno"},{"name":"Matsuo Keitaro"},{"name":"Yamamoto Masayuki"},{"name":"Sasaki Makoto"},{"name":"Tsugane Shoichiro"},{"name":"Iwasaki Motoki"}],"ja":[{"name":"Hanyuda Akiko"},{"name":"Goto Atsushi"},{"name":"Nakatochi Masahiro"},{"name":"Sutoh Yoichi"},{"name":"Narita Akira"},{"name":"Nakano Shiori"},{"name":"Katagiri Ryoko"},{"name":"Wakai Kenji"},{"name":"Takashima Naoyuki"},{"name":"Koyama Teruhide"},{"name":"有澤 孝吉"},{"name":"Imoto Issei"},{"name":"Momozawa Yukihide"},{"name":"Tanno Kozo"},{"name":"Shimizu Atsushi"},{"name":"Hozawa Atsushi"},{"name":"Kinoshita Kengo"},{"name":"Yamaji Taiki"},{"name":"Sawada Norie"},{"name":"Iwagami Masao"},{"name":"Yuki Kenya"},{"name":"Tsubota Kazuo"},{"name":"Negishi Kazuno"},{"name":"Matsuo Keitaro"},{"name":"Yamamoto Masayuki"},{"name":"Sasaki Makoto"},{"name":"Tsugane Shoichiro"},{"name":"Iwasaki Motoki"}]},"description":{"en":"A meta-analysis suggests a relationship between abnormal glucose metabolism and primary open-angle glaucoma (POAG); however, the causal association between them remains controversial. We therefore conducted a Mendelian randomization (MR) study to assess the causal association between genetically predicted glycemic traits and the risk of POAG. Two-sample MR design. We examined the genetically predicted measures of fasting glucose, hemoglobin A1c (HbA1c), and fasting C-peptide, in relation to POAG. For the single nucleotide polymorphism (SNP)-exposure analyses, we meta-analyzed the study-level genome-wide associations of fasting glucose levels (n = 17,289; n of SNPs = 34), HbA1c (n = 52,802; n of SNPs = 43), and fasting C-peptide levels (n=1666; n of SNPs = 17) from the Japanese Consortium of Genetic Epidemiology studies. We used summary statistics from the BioBank Japan projects (n = 3980 POAG cases and 18,815 controls) for the SNP-outcome association. We observed no association of genetically predicted HbA1c and fasting C-peptide with POAG. The MR inverse-variance-weighted (IVW) odds ratios (ORs) were 1.44 (95% confidence interval [CI], 0.78-2.65; P = .25) for HbA1c (per 1% increment) and 0.92 (95% CI, 0.56-1.53; P = .76) for fasting C-peptide (per 2-fold increment). A significant association between fasting glucose (per 10 mg/dL-increment) and POAG was observed according to the MR IVW analysis (OR = 1.48 [95% CI, 1.10-1.79, P = .009]); however, sensitivity analyses, including MR-Egger and weighted-median methods, did not support this association (P > .10). We did not observe strong evidence to support the association between genetically predicted glycemic traits and POAG in the Japanese population.","ja":"A meta-analysis suggests a relationship between abnormal glucose metabolism and primary open-angle glaucoma (POAG); however, the causal association between them remains controversial. We therefore conducted a Mendelian randomization (MR) study to assess the causal association between genetically predicted glycemic traits and the risk of POAG. Two-sample MR design. We examined the genetically predicted measures of fasting glucose, hemoglobin A1c (HbA1c), and fasting C-peptide, in relation to POAG. For the single nucleotide polymorphism (SNP)-exposure analyses, we meta-analyzed the study-level genome-wide associations of fasting glucose levels (n = 17,289; n of SNPs = 34), HbA1c (n = 52,802; n of SNPs = 43), and fasting C-peptide levels (n=1666; n of SNPs = 17) from the Japanese Consortium of Genetic Epidemiology studies. We used summary statistics from the BioBank Japan projects (n = 3980 POAG cases and 18,815 controls) for the SNP-outcome association. We observed no association of genetically predicted HbA1c and fasting C-peptide with POAG. The MR inverse-variance-weighted (IVW) odds ratios (ORs) were 1.44 (95% confidence interval [CI], 0.78-2.65; P = .25) for HbA1c (per 1% increment) and 0.92 (95% CI, 0.56-1.53; P = .76) for fasting C-peptide (per 2-fold increment). A significant association between fasting glucose (per 10 mg/dL-increment) and POAG was observed according to the MR IVW analysis (OR = 1.48 [95% CI, 1.10-1.79, P = .009]); however, sensitivity analyses, including MR-Egger and weighted-median methods, did not support this association (P > .10). We did not observe strong evidence to support the association between genetically predicted glycemic traits and POAG in the Japanese population."},"publication_date":"2022-09-22","publication_name":{"en":"American Journal of Ophthalmology","ja":"American Journal of Ophthalmology"},"volume":"Vol.245","starting_page":"193","ending_page":"201","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.ajo.2022.09.004"],"issn":["1879-1891"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/36229362","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=391698","label":"url"}],"paper_title":{"en":"Irregular sleep and all-cause mortality: a large prospective cohort study","ja":"Irregular sleep and all-cause mortality: a large prospective cohort study"},"authors":{"en":[{"name":"Omichi Chie"},{"name":"Koyama Teruhide"},{"name":"Kadotani Hiroshi"},{"name":"Ozaki Etsuko"},{"name":"Tomida Satomi"},{"name":"Yoshida Tamami"},{"name":"Otonari Jun"},{"name":"Ikezaki Hiroaki"},{"name":"Hara Megumi"},{"name":"Tanaka Keitaro"},{"name":"Tamura Takashi"},{"name":"Nagayoshi Mako"},{"name":"Okada Rieko"},{"name":"Kubo Yoko"},{"name":"Oze Isao"},{"name":"Matsuo Keitaro"},{"name":"Nakamura Yohko"},{"name":"Kusakabe Miho"},{"name":"Ibusuki Rie"},{"name":"Shibuya Kenichi"},{"name":"Suzuki Sadao"},{"name":"Watanabe Miki"},{"name":"Kuriki Kiyonori"},{"name":"Takashima Naoyuki"},{"name":"Kadota Aya"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Arisawa Kokichi"},{"name":"Takeuchi Kenji"},{"name":"Wakai Kenji"}],"ja":[{"name":"Omichi Chie"},{"name":"Koyama Teruhide"},{"name":"Kadotani Hiroshi"},{"name":"Ozaki Etsuko"},{"name":"Tomida Satomi"},{"name":"Yoshida Tamami"},{"name":"Otonari Jun"},{"name":"Ikezaki Hiroaki"},{"name":"Hara Megumi"},{"name":"Tanaka Keitaro"},{"name":"Tamura Takashi"},{"name":"Nagayoshi Mako"},{"name":"Okada Rieko"},{"name":"Kubo Yoko"},{"name":"Oze Isao"},{"name":"Matsuo Keitaro"},{"name":"Nakamura Yohko"},{"name":"Kusakabe Miho"},{"name":"Ibusuki Rie"},{"name":"Shibuya Kenichi"},{"name":"Suzuki Sadao"},{"name":"Watanabe Miki"},{"name":"Kuriki Kiyonori"},{"name":"Takashima Naoyuki"},{"name":"Kadota Aya"},{"name":"勝浦-釜野 桜子"},{"name":"有澤 孝吉"},{"name":"Takeuchi Kenji"},{"name":"Wakai Kenji"}]},"description":{"en":"Previous studies using objective parameters have shown that irregular sleep is associated with the disease incidence, progression, or mortality. This study aimed to determine the association between subjective sleep duration and sleep regularity, with mortality in a large population. Participants were from the Japan Multi-Institutional Collaborative Cohort study. We obtained information from each participant on sleep duration, sleep regularity, and demographics and overall lifestyle using self-administered questionnaires. We defined sleep regularity according to participants' subjective assessment of sleep/wake time regularity. Participants (n = 81,382, mean age: 58.1 ± 9.1years, males: 44.2%) were classified into 6 groups according to sleep duration and sleep regularity. Hazard ratios (HR) for time-to-event of death were calculated using the Cox proportional hazards model. The mean follow-up period was 9.1 years and the mean sleep duration was 6.6 h/day. Irregular sleep significantly increased the risk of all-cause mortality in all models compared with regular sleep (HR 1.30, 95% confidence interval; CI, 1.18-1.44), regardless of sleep duration. Multivariable analysis of the 6 groups by sleep pattern (sleep regularity and duration) showed irregular sleep and sleep durations of <6 h/day, 6 to <8 h/day, or 8 h/day were associated with a 1.2-1.5-fold increases in mortality, compared to regular sleep and sleep duration of 6 to <8 h/day. Our study shows an association between sleep irregularity and all-cause mortality in a large Japanese population. Our findings provide further confirmation of the need to consider not only sleep duration, but also the regularity aspect of sleep schedules.","ja":"Previous studies using objective parameters have shown that irregular sleep is associated with the disease incidence, progression, or mortality. This study aimed to determine the association between subjective sleep duration and sleep regularity, with mortality in a large population. Participants were from the Japan Multi-Institutional Collaborative Cohort study. We obtained information from each participant on sleep duration, sleep regularity, and demographics and overall lifestyle using self-administered questionnaires. We defined sleep regularity according to participants' subjective assessment of sleep/wake time regularity. Participants (n = 81,382, mean age: 58.1 ± 9.1years, males: 44.2%) were classified into 6 groups according to sleep duration and sleep regularity. Hazard ratios (HR) for time-to-event of death were calculated using the Cox proportional hazards model. The mean follow-up period was 9.1 years and the mean sleep duration was 6.6 h/day. Irregular sleep significantly increased the risk of all-cause mortality in all models compared with regular sleep (HR 1.30, 95% confidence interval; CI, 1.18-1.44), regardless of sleep duration. Multivariable analysis of the 6 groups by sleep pattern (sleep regularity and duration) showed irregular sleep and sleep durations of <6 h/day, 6 to <8 h/day, or 8 h/day were associated with a 1.2-1.5-fold increases in mortality, compared to regular sleep and sleep duration of 6 to <8 h/day. Our study shows an association between sleep irregularity and all-cause mortality in a large Japanese population. Our findings provide further confirmation of the need to consider not only sleep duration, but also the regularity aspect of sleep schedules."},"publication_date":"2022-09","publication_name":{"en":"Sleep Health","ja":"Sleep Health"},"volume":"Vol.8","number":"No.6","starting_page":"678","ending_page":"683","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.sleh.2022.08.010"],"issn":["2352-7226"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/117839","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/36123890","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=391417","label":"url"}],"paper_title":{"en":"Genetic polymorphism of pleiotrophin is associated with pain experience in Japanese adults: case-control study","ja":"Genetic polymorphism of pleiotrophin is associated with pain experience in Japanese adults: case-control study"},"authors":{"en":[{"name":"Saita Kosuke"},{"name":"Sumitani Masahiko"},{"name":"Nishizawa Daisuke"},{"name":"Tamura Takashi"},{"name":"Ikeda Kazutaka"},{"name":"Wakai Kenji"},{"name":"Sudo Yoshika"},{"name":"Abe Hiroaki"},{"name":"Otonari Jun"},{"name":"Ikezaki Hiroaki"},{"name":"Takeuchi Kenji"},{"name":"Hisida Asahi"},{"name":"Tanaka Keitaro"},{"name":"Shimanoe Chisato"},{"name":"Takezaki Toshiro"},{"name":"Ibusuki Rie"},{"name":"Oze Isao"},{"name":"Ito Hidemi"},{"name":"Ozaki Etsuko"},{"name":"Matsui Daisuke"},{"name":"Nakamura Yohko"},{"name":"Kusakabe Miho"},{"name":"Suzuki Sadao"},{"name":"Nakagawa-Senda Hiroko"},{"name":"Arisawa Kokichi"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Kuriki Kiyonori"},{"name":"Kita Yoshikuni"},{"name":"Nakamura Yasuyuki"},{"name":"Momozawa Yukihide"},{"name":"Uchida Kanji"}],"ja":[{"name":"Saita Kosuke"},{"name":"Sumitani Masahiko"},{"name":"Nishizawa Daisuke"},{"name":"Tamura Takashi"},{"name":"Ikeda Kazutaka"},{"name":"Wakai Kenji"},{"name":"Sudo Yoshika"},{"name":"Abe Hiroaki"},{"name":"Otonari Jun"},{"name":"Ikezaki Hiroaki"},{"name":"Takeuchi Kenji"},{"name":"Hisida Asahi"},{"name":"Tanaka Keitaro"},{"name":"Shimanoe Chisato"},{"name":"Takezaki Toshiro"},{"name":"Ibusuki Rie"},{"name":"Oze Isao"},{"name":"Ito Hidemi"},{"name":"Ozaki Etsuko"},{"name":"Matsui Daisuke"},{"name":"Nakamura Yohko"},{"name":"Kusakabe Miho"},{"name":"Suzuki Sadao"},{"name":"Nakagawa-Senda Hiroko"},{"name":"有澤 孝吉"},{"name":"勝浦-釜野 桜子"},{"name":"Kuriki Kiyonori"},{"name":"Kita Yoshikuni"},{"name":"Nakamura Yasuyuki"},{"name":"Momozawa Yukihide"},{"name":"Uchida Kanji"}]},"description":{"en":"Genetic factors play a role in individual differences in pain experience. Here, we performed a genome-wide association study (GWAS) to identify novel loci regulating pain processing. We conducted a 2-stage GWAS and the candidate single-nucleotide polymorphisms (SNPs) association study on pain experience using an exploratory cohort of patients with cancer pain. The confirmatory cohort comprised of participants from the general population with and without habitual use of analgesic medication. In the exploratory cohort, we evaluated pain intensity using a numerical rating scale, recorded daily opioid dosages, and calculated pain reduction rate. In the confirmatory cohort, pain experience was defined as habitual nonsteroidal anti-inflammatory drug usage. Using linear regression models, we identified candidate SNP in the exploratory samples, and tested the association between phenotype and experienced pain in the confirmatory samples. We found 1 novel SNP (rs11764598)-located on the gene encoding for pleiotrophin on chromosome 7-that passed the genome-wide suggestive significance at 20% false discovery rate (FDR) correction in the exploratory samples of patients with cancer pain (P = 1.31 × 10-7, FDR = 0.101). We confirmed its significant association with daily analgesic usage in the confirmatory cohort (P = .028), although the minor allele affected pain experience in an opposite manner. We identified a novel genetic variant associated with pain experience. Further studies are required to validate the role of pleiotrophin in pain processing.","ja":"Genetic factors play a role in individual differences in pain experience. Here, we performed a genome-wide association study (GWAS) to identify novel loci regulating pain processing. We conducted a 2-stage GWAS and the candidate single-nucleotide polymorphisms (SNPs) association study on pain experience using an exploratory cohort of patients with cancer pain. The confirmatory cohort comprised of participants from the general population with and without habitual use of analgesic medication. In the exploratory cohort, we evaluated pain intensity using a numerical rating scale, recorded daily opioid dosages, and calculated pain reduction rate. In the confirmatory cohort, pain experience was defined as habitual nonsteroidal anti-inflammatory drug usage. Using linear regression models, we identified candidate SNP in the exploratory samples, and tested the association between phenotype and experienced pain in the confirmatory samples. We found 1 novel SNP (rs11764598)-located on the gene encoding for pleiotrophin on chromosome 7-that passed the genome-wide suggestive significance at 20% false discovery rate (FDR) correction in the exploratory samples of patients with cancer pain (P = 1.31 × 10-7, FDR = 0.101). We confirmed its significant association with daily analgesic usage in the confirmatory cohort (P = .028), although the minor allele affected pain experience in an opposite manner. We identified a novel genetic variant associated with pain experience. Further studies are required to validate the role of pleiotrophin in pain processing."},"publication_date":"2022-08-13","publication_name":{"en":"Medicine","ja":"Medicine"},"volume":"Vol.101","number":"No.37","starting_page":"e30580","ending_page":"e30580","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1097/MD.0000000000030580"],"issn":["1536-5964"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/117591","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/35802721","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=386207","label":"url"}],"paper_title":{"en":"Associations of metabolic syndrome and metabolically unhealthy obesity with cancer mortality: The Japan Multi-Institutional Collaborative Cohort (J-MICC) Study","ja":"Associations of metabolic syndrome and metabolically unhealthy obesity with cancer mortality: The Japan Multi-Institutional Collaborative Cohort (J-MICC) Study"},"authors":{"en":[{"name":"Nguyen Van Tien"},{"name":"Arisawa Kokichi"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Ishizu Masashi"},{"name":"Nagayoshi Mako"},{"name":"Okada Rieko"},{"name":"Hishida Asahi"},{"name":"Tamura Takashi"},{"name":"Hara Megumi"},{"name":"Tanaka Keitaro"},{"name":"Nishimoto Daisaku"},{"name":"Shibuya Keiichi"},{"name":"Koyama Teruhide"},{"name":"Watanabe Isao"},{"name":"Suzuki Sadao"},{"name":"Nishiyama Takeshi"},{"name":"Kuriki Kiyonori"},{"name":"Nakamura Yasuyuki"},{"name":"Saito Yoshino"},{"name":"Ikezaki Hiroaki"},{"name":"Otonari Jun"},{"name":"Koyanagi N. Yuriko"},{"name":"Matsuo Keitaro"},{"name":"Mikami Haruo"},{"name":"Kusakabe Miho"},{"name":"Takeuchi Kenji"},{"name":"Wakai Kenji"}],"ja":[{"name":"Nguyen Van Tien"},{"name":"有澤 孝吉"},{"name":"勝浦-釜野 桜子"},{"name":"石津 将"},{"name":"Nagayoshi Mako"},{"name":"Okada Rieko"},{"name":"Hishida Asahi"},{"name":"Tamura Takashi"},{"name":"Hara Megumi"},{"name":"Tanaka Keitaro"},{"name":"Nishimoto Daisaku"},{"name":"Shibuya Keiichi"},{"name":"Koyama Teruhide"},{"name":"Watanabe Isao"},{"name":"Suzuki Sadao"},{"name":"Nishiyama Takeshi"},{"name":"Kuriki Kiyonori"},{"name":"Nakamura Yasuyuki"},{"name":"Saito Yoshino"},{"name":"Ikezaki Hiroaki"},{"name":"Otonari Jun"},{"name":"Koyanagi N. Yuriko"},{"name":"Matsuo Keitaro"},{"name":"Mikami Haruo"},{"name":"Kusakabe Miho"},{"name":"Takeuchi Kenji"},{"name":"Wakai Kenji"}]},"description":{"en":"The association between metabolic syndrome (MetS) and the risk of death from cancer is still a controversial issue. The purpose of this study was to examine the associations of MetS and metabolically unhealthy obesity (MUHO) with cancer mortality in a Japanese population. We used data from the Japan Multi-Institutional Collaborative Cohort Study. The study population consisted of 28,554 eligible subjects (14,103 men and 14,451 women) aged 35-69 years. MetS was diagnosed based on the criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) and the Japan Society for the Study of Obesity (JASSO), using the body mass index instead of waist circumference. The Cox proportional hazards analysis was used to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for total cancer mortality in relation to MetS and its components. Additionally, the associations of obesity and the metabolic health status with cancer mortality were examined. During an average 6.9-year follow-up, there were 192 deaths from cancer. The presence of MetS was significantly correlated with increased total cancer mortality when the JASSO criteria were used (HR = 1.51, 95% CI 1.04-2.21), but not when the NCEP-ATP III criteria were used (HR = 1.09, 95% CI 0.78-1.53). Metabolic risk factors, elevated fasting blood glucose, and MUHO were positively associated with cancer mortality (P <0.05). MetS diagnosed using the JASSO criteria and MUHO were associated with an increased risk of total cancer mortality in the Japanese population.","ja":"The association between metabolic syndrome (MetS) and the risk of death from cancer is still a controversial issue. The purpose of this study was to examine the associations of MetS and metabolically unhealthy obesity (MUHO) with cancer mortality in a Japanese population. We used data from the Japan Multi-Institutional Collaborative Cohort Study. The study population consisted of 28,554 eligible subjects (14,103 men and 14,451 women) aged 35-69 years. MetS was diagnosed based on the criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) and the Japan Society for the Study of Obesity (JASSO), using the body mass index instead of waist circumference. The Cox proportional hazards analysis was used to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for total cancer mortality in relation to MetS and its components. Additionally, the associations of obesity and the metabolic health status with cancer mortality were examined. During an average 6.9-year follow-up, there were 192 deaths from cancer. The presence of MetS was significantly correlated with increased total cancer mortality when the JASSO criteria were used (HR = 1.51, 95% CI 1.04-2.21), but not when the NCEP-ATP III criteria were used (HR = 1.09, 95% CI 0.78-1.53). Metabolic risk factors, elevated fasting blood glucose, and MUHO were positively associated with cancer mortality (P <0.05). MetS diagnosed using the JASSO criteria and MUHO were associated with an increased risk of total cancer mortality in the Japanese population."},"publication_date":"2022-06-29","publication_name":{"en":"PLoS ONE","ja":"PLoS ONE"},"volume":"Vol.17","number":"No.7","starting_page":"e0269550","ending_page":"e0269550","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1371/journal.pone.0269550"],"issn":["1932-6203"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/35666837","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85136243489&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=391416","label":"url"}],"paper_title":{"en":"Associations of genome-wide polygenic risk score and risk factors with hypertension in a Japanese population","ja":"Associations of genome-wide polygenic risk score and risk factors with hypertension in a Japanese population"},"authors":{"en":[{"name":"Ryosuke Fujii"},{"name":"Asahi Hishida"},{"name":"Masahiro Nakatochi"},{"name":"Yoshiki Tsuboi"},{"name":"Koji Suzuki"},{"name":"Takaaki Kondo"},{"name":"Hiroaki Ikezaki"},{"name":"Megumi Hara"},{"name":"Rieko Okada"},{"name":"Takashi Tamura"},{"name":"Ippei Shimoshikiryo"},{"name":"Sadao Suzuki"},{"name":"Teruhide Koyama"},{"name":"Kiyonori Kuriki"},{"name":"Naoyuki Takashima"},{"name":"Arisawa Kokichi"},{"name":"Yukihide Momozawa"},{"name":"Michiaki Kubo"},{"name":"Kenji Takeuchi"},{"name":"Kenji Wakai"}],"ja":[{"name":"Ryosuke Fujii"},{"name":"Asahi Hishida"},{"name":"Masahiro Nakatochi"},{"name":"Yoshiki Tsuboi"},{"name":"Koji Suzuki"},{"name":"Takaaki Kondo"},{"name":"Hiroaki Ikezaki"},{"name":"Megumi Hara"},{"name":"Rieko Okada"},{"name":"Takashi Tamura"},{"name":"Ippei Shimoshikiryo"},{"name":"Sadao Suzuki"},{"name":"Teruhide Koyama"},{"name":"Kiyonori Kuriki"},{"name":"Naoyuki Takashima"},{"name":"有澤 孝吉"},{"name":"Yukihide Momozawa"},{"name":"Michiaki Kubo"},{"name":"Kenji Takeuchi"},{"name":"Kenji Wakai"}]},"description":{"en":"Although many polygenic risk scores (PRS) for cardiovascular traits have been developed in European populations, it is an urgent task to construct a PRS and to evaluate its ability in non-European populations. We developed a genome-wide PRS for blood pressure in a Japanese population and examined the associations between this PRS and hypertension prevalence. We performed a cross-sectional study in 11 252 Japanese individuals who participated in the J-MICC (Japan Multi-Institutional Collaborative Cohort) study. Using publicly available GWAS summary statistics from Biobank Japan, we developed the PRS in the target data (n=7876). With >30 000 single nucleotide polymorphisms, we evaluated PRS performance in the test data (n=3376). Hypertension was defined as systolic blood pressure of 130 mm Hg or more, or diastolic blood pressure of 85 mm Hg or more, or taking an antihypertensive drug. Compared with the middle PRS quintile, the prevalence of hypertension at the top PRS quintile was higher independently from traditional risk factors (odds ratio, 1.73 [95% CI, 1.32-2.27]). The difference of mean systolic blood pressure and diastolic blood pressure between the middle and the top PRS quintile was 4.55 (95% CI, 2.26-6.85) and 2.32 (95% CI, 0.86-3.78) mm Hg, respectively. Subgroups reflecting combinations of Japanese PRS and modifiable lifestyles and factors (smoking, alcohol intake, sedentary time, and obesity) were associated with the prevalence of hypertension. A European-derived PRS was not associated with hypertension in our participants. A PRS for blood pressure was significantly associated with hypertension and BP traits in a general Japanese population. Our findings also highlighted the importance of a combination of PRS and risk factors for identifying high-risk subgroups.","ja":"Although many polygenic risk scores (PRS) for cardiovascular traits have been developed in European populations, it is an urgent task to construct a PRS and to evaluate its ability in non-European populations. We developed a genome-wide PRS for blood pressure in a Japanese population and examined the associations between this PRS and hypertension prevalence. We performed a cross-sectional study in 11 252 Japanese individuals who participated in the J-MICC (Japan Multi-Institutional Collaborative Cohort) study. Using publicly available GWAS summary statistics from Biobank Japan, we developed the PRS in the target data (n=7876). With >30 000 single nucleotide polymorphisms, we evaluated PRS performance in the test data (n=3376). Hypertension was defined as systolic blood pressure of 130 mm Hg or more, or diastolic blood pressure of 85 mm Hg or more, or taking an antihypertensive drug. Compared with the middle PRS quintile, the prevalence of hypertension at the top PRS quintile was higher independently from traditional risk factors (odds ratio, 1.73 [95% CI, 1.32-2.27]). The difference of mean systolic blood pressure and diastolic blood pressure between the middle and the top PRS quintile was 4.55 (95% CI, 2.26-6.85) and 2.32 (95% CI, 0.86-3.78) mm Hg, respectively. Subgroups reflecting combinations of Japanese PRS and modifiable lifestyles and factors (smoking, alcohol intake, sedentary time, and obesity) were associated with the prevalence of hypertension. A European-derived PRS was not associated with hypertension in our participants. A PRS for blood pressure was significantly associated with hypertension and BP traits in a general Japanese population. Our findings also highlighted the importance of a combination of PRS and risk factors for identifying high-risk subgroups."},"publication_date":"2022-03-12","publication_name":{"en":"Circulation. Genomic and Precision Medicine","ja":"Circulation. Genomic and Precision Medicine"},"volume":"Vol.15","number":"No.4","starting_page":"e003612","ending_page":"e003612","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1161/CIRCGEN.121.003612"],"issn":["2574-8300"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=384366","label":"url"}],"paper_title":{"en":"A genome-wide association study on adherence to low-carbohydrate diets in Japanese","ja":"A genome-wide association study on adherence to low-carbohydrate diets in Japanese"},"authors":{"en":[{"name":"Nakamura Yasuyuki"},{"name":"Tamura Takashi"},{"name":"Narita Akira"},{"name":"Shimizu Atsushi"},{"name":"Sutoh Yoichi"},{"name":"Takashima Naoyuki"},{"name":"Matsui Kenji"},{"name":"Miyagawa Naoko"},{"name":"Kadota Aya"},{"name":"Miura Katsuyuki"},{"name":"Otonari Jun"},{"name":"Ikezaki Hiroaki"},{"name":"Hishida Asahi"},{"name":"Nagayoshi Mako"},{"name":"Okada Rieko"},{"name":"Kubo Yoko"},{"name":"Tanaka Keitaro"},{"name":"Shimanoe Chisato"},{"name":"Ibusuki Rie"},{"name":"Nishimoto Daisaku"},{"name":"Oze Isao"},{"name":"Ito Hidemi"},{"name":"Ozaki Etsuko"},{"name":"Matsui Daisuke"},{"name":"Mikami Haruo"},{"name":"Kusakabe Miho"},{"name":"Suzuki Sadao"},{"name":"Watanabe Miki"},{"name":"Arisawa Kokichi"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Kuriki Kiyonori"},{"name":"Nakatochi Masahiro"},{"name":"Momozawa Yukihide"},{"name":"Kubo Michiaki"},{"name":"Takeuchi Kenji"},{"name":"Wakai Kenji"}],"ja":[{"name":"Nakamura Yasuyuki"},{"name":"Tamura Takashi"},{"name":"Narita Akira"},{"name":"Shimizu Atsushi"},{"name":"Sutoh Yoichi"},{"name":"Takashima Naoyuki"},{"name":"Matsui Kenji"},{"name":"Miyagawa Naoko"},{"name":"Kadota Aya"},{"name":"Miura Katsuyuki"},{"name":"Otonari Jun"},{"name":"Ikezaki Hiroaki"},{"name":"Hishida Asahi"},{"name":"Nagayoshi Mako"},{"name":"Okada Rieko"},{"name":"Kubo Yoko"},{"name":"Tanaka Keitaro"},{"name":"Shimanoe Chisato"},{"name":"Ibusuki Rie"},{"name":"Nishimoto Daisaku"},{"name":"Oze Isao"},{"name":"Ito Hidemi"},{"name":"Ozaki Etsuko"},{"name":"Matsui Daisuke"},{"name":"Mikami Haruo"},{"name":"Kusakabe Miho"},{"name":"Suzuki Sadao"},{"name":"Watanabe Miki"},{"name":"有澤 孝吉"},{"name":"勝浦-釜野 桜子"},{"name":"Kuriki Kiyonori"},{"name":"Nakatochi Masahiro"},{"name":"Momozawa Yukihide"},{"name":"Kubo Michiaki"},{"name":"Takeuchi Kenji"},{"name":"Wakai Kenji"}]},"publication_date":"2022-01-24","publication_name":{"en":"European Journal of Clinical Nutrition","ja":"European Journal of Clinical Nutrition"},"languages":["eng"],"referee":true,"identifiers":{"doi":["10.1038/s41430-022-01090-w"],"issn":["1476-5640"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/117191","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/34997128","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383791","label":"url"}],"paper_title":{"en":"Association of perceived stress and coping strategies with the renal function in middleaged and older Japanese men and women","ja":"Association of perceived stress and coping strategies with the renal function in middleaged and older Japanese men and women"},"authors":{"en":[{"name":"Koga Kayoko"},{"name":"Hara Megumi"},{"name":"Shimanoe Chisato"},{"name":"Nishida Yuichiro"},{"name":"Furukawa Takuma"},{"name":"Iwasaka Chiharu"},{"name":"Tanaka Keitaro"},{"name":"Otonari Jun"},{"name":"Ikezaki Hiroaki"},{"name":"Kubo Yoko"},{"name":"Kato Yasufumi"},{"name":"Tamura Takashi"},{"name":"Hishida Asahi"},{"name":"Matsuo Keitaro"},{"name":"Ito Hidemi"},{"name":"Nakamura Yohko"},{"name":"Kusakabe Miho"},{"name":"Nishimoto Daisaku"},{"name":"Shibuya Keiichi"},{"name":"Suzuki Sadao"},{"name":"Watanabe Miki"},{"name":"Ozaki Etsuko"},{"name":"Matsui Daisuke"},{"name":"Kuriki Kiyonori"},{"name":"Takashima Naoyuki"},{"name":"Kadota Aya"},{"name":"Arisawa Kokichi"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Takeuchi Kenji"},{"name":"Wakai Kenji"}],"ja":[{"name":"Koga Kayoko"},{"name":"Hara Megumi"},{"name":"Shimanoe Chisato"},{"name":"Nishida Yuichiro"},{"name":"Furukawa Takuma"},{"name":"Iwasaka Chiharu"},{"name":"Tanaka Keitaro"},{"name":"Otonari Jun"},{"name":"Ikezaki Hiroaki"},{"name":"Kubo Yoko"},{"name":"Kato Yasufumi"},{"name":"Tamura Takashi"},{"name":"Hishida Asahi"},{"name":"Matsuo Keitaro"},{"name":"Ito Hidemi"},{"name":"Nakamura Yohko"},{"name":"Kusakabe Miho"},{"name":"Nishimoto Daisaku"},{"name":"Shibuya Keiichi"},{"name":"Suzuki Sadao"},{"name":"Watanabe Miki"},{"name":"Ozaki Etsuko"},{"name":"Matsui Daisuke"},{"name":"Kuriki Kiyonori"},{"name":"Takashima Naoyuki"},{"name":"Kadota Aya"},{"name":"有澤 孝吉"},{"name":"勝浦-釜野 桜子"},{"name":"Takeuchi Kenji"},{"name":"Wakai Kenji"}]},"description":{"en":"Elucidating the risk factors for chronic kidney disease is important for preventing end-stage renal disease and reducing mortality. However, little is known about the roles of psychosocial stress and stress coping behaviors in deterioration of the renal function, as measured by the estimated glomerular filtration rate (eGFR). This cross-sectional study of middle-aged and older Japanese men (n = 31,703) and women (n = 38,939) investigated whether perceived stress and coping strategies (emotional expression, emotional support seeking, positive reappraisal, problem solving, and disengagement) were related to the eGFR, with mutual interactions. In multiple linear regression analyses adjusted for age, area, lifestyle factors, and psychosocial variables, we found a significant inverse association between perceived stress and the eGFR in men (P = 0.02), but not women. This male-specific inverse association was slightly attenuated after adjustment for the history of hypertension and diabetes and was more evident in lower levels of emotional expression (P = 0.003). Unexpectedly, problem solving in men (P < 0.001) and positive reappraisal in women (P = 0.002) also showed an inverse association with the eGFR. Perceived stress may affect the eGFR, partly through the development of hypertension and diabetes. The unexpected findings regarding coping strategies require the clarification of the underlying mechanisms, including the hormonal and immunological aspects.","ja":"Elucidating the risk factors for chronic kidney disease is important for preventing end-stage renal disease and reducing mortality. However, little is known about the roles of psychosocial stress and stress coping behaviors in deterioration of the renal function, as measured by the estimated glomerular filtration rate (eGFR). This cross-sectional study of middle-aged and older Japanese men (n = 31,703) and women (n = 38,939) investigated whether perceived stress and coping strategies (emotional expression, emotional support seeking, positive reappraisal, problem solving, and disengagement) were related to the eGFR, with mutual interactions. In multiple linear regression analyses adjusted for age, area, lifestyle factors, and psychosocial variables, we found a significant inverse association between perceived stress and the eGFR in men (P = 0.02), but not women. This male-specific inverse association was slightly attenuated after adjustment for the history of hypertension and diabetes and was more evident in lower levels of emotional expression (P = 0.003). Unexpectedly, problem solving in men (P < 0.001) and positive reappraisal in women (P = 0.002) also showed an inverse association with the eGFR. Perceived stress may affect the eGFR, partly through the development of hypertension and diabetes. The unexpected findings regarding coping strategies require the clarification of the underlying mechanisms, including the hormonal and immunological aspects."},"publication_date":"2022-01-01","publication_name":{"en":"Scientific Reports","ja":"Scientific Reports"},"volume":"Vol.12","number":"No.1","starting_page":"291","ending_page":"291","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1038/s41598-021-04324-2"],"issn":["2045-2322"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/117189","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/35045125","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=384008","label":"url"}],"paper_title":{"en":"Associations of breastfeeding history with metabolic syndrome and cardiovascular risk factors in community-dwelling parous women: The Japan Multi-Institutional Collaborative Cohort Study","ja":"Associations of breastfeeding history with metabolic syndrome and cardiovascular risk factors in community-dwelling parous women: The Japan Multi-Institutional Collaborative Cohort Study"},"authors":{"en":[{"name":"Matsunaga Takashi"},{"name":"Kadomatsu Yuka"},{"name":"Tsukamoto Mineko"},{"name":"Kubo Yoko"},{"name":"Okada Rieko"},{"name":"Nagayoshi Mako"},{"name":"Tamura Takashi"},{"name":"Hishida Asahi"},{"name":"Takezaki Toshiro"},{"name":"Shimoshikiryo Ippei"},{"name":"Suzuki Sadao"},{"name":"Nakagawa Hiroko"},{"name":"Takashima Naoyuki"},{"name":"Saito Yoshino"},{"name":"Kuriki Kiyonori"},{"name":"Arisawa Kokichi"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Kuriyama Nagato"},{"name":"Matsui Daisuke"},{"name":"Mikami Haruo"},{"name":"Nakamura Yohko"},{"name":"Oze Isao"},{"name":"Ito Hidemi"},{"name":"Murata Masayuki"},{"name":"Ikezaki Hiroaki"},{"name":"Nishida Yuichiro"},{"name":"Shimanoe Chisato"},{"name":"Takeuchi Kenji"},{"name":"Wakai Kenji"}],"ja":[{"name":"Matsunaga Takashi"},{"name":"Kadomatsu Yuka"},{"name":"Tsukamoto Mineko"},{"name":"Kubo Yoko"},{"name":"Okada Rieko"},{"name":"Nagayoshi Mako"},{"name":"Tamura Takashi"},{"name":"Hishida Asahi"},{"name":"Takezaki Toshiro"},{"name":"Shimoshikiryo Ippei"},{"name":"Suzuki Sadao"},{"name":"Nakagawa Hiroko"},{"name":"Takashima Naoyuki"},{"name":"Saito Yoshino"},{"name":"Kuriki Kiyonori"},{"name":"有澤 孝吉"},{"name":"勝浦-釜野 桜子"},{"name":"Kuriyama Nagato"},{"name":"Matsui Daisuke"},{"name":"Mikami Haruo"},{"name":"Nakamura Yohko"},{"name":"Oze Isao"},{"name":"Ito Hidemi"},{"name":"Murata Masayuki"},{"name":"Ikezaki Hiroaki"},{"name":"Nishida Yuichiro"},{"name":"Shimanoe Chisato"},{"name":"Takeuchi Kenji"},{"name":"Wakai Kenji"}]},"description":{"en":"The aim of the present study was to investigate the associations between breastfeeding and the prevalence of metabolic syndrome in community-dwelling parous women and to clarify whether the associations depend on age. The present cross-sectional study included 11,118 women, aged 35-69 years. Participants' longest breastfeeding duration for one child and their number of breastfed children were assessed using a self-administered questionnaire, and their total breastfeeding duration was approximated as a product of the number of breastfed children and the longest breastfeeding duration. The longest and the total breastfeeding durations were categorized into none and tertiles above 0 months. Metabolic syndrome and cardiovascular risk factors (obesity, hypertension, dyslipidemia, and hyperglycemia) were defined as primary and secondary outcomes, respectively. Associations between breastfeeding history and metabolic syndrome or each cardiovascular risk factor were assessed using multivariable unconditional logistic regression analysis. Among a total of 11,118 women, 10,432 (93.8%) had ever breastfed, and 1,236 (11.1%) had metabolic syndrome. In participants aged <55 years, an inverse dose-response relationship was found between the number of breastfed children and the prevalence of metabolic syndrome; multivariable-adjusted odds ratios for 1, 2, 3, and ≥4 breastfed children were 0.60 (95% confidence interval [CI]: 0.31 to 1.17), 0.50 (95% CI: 0.29 to 0.87), 0.44 (95% CI: 0.24 to 0.84), and 0.35 (95% CI: 0.14 to 0.89), respectively. The longest and total breastfeeding durations of longer than 0 months were also associated with lower odds of metabolic syndrome relative to no breastfeeding history in participants aged <55 years. In contrast, all measures of breastfeeding history were not significantly associated with metabolic syndrome and cardiovascular risk factors in participants aged ≥55 years old. Breastfeeding history may be related to lower prevalence of metabolic syndrome in middle-aged parous women.","ja":"The aim of the present study was to investigate the associations between breastfeeding and the prevalence of metabolic syndrome in community-dwelling parous women and to clarify whether the associations depend on age. The present cross-sectional study included 11,118 women, aged 35-69 years. Participants' longest breastfeeding duration for one child and their number of breastfed children were assessed using a self-administered questionnaire, and their total breastfeeding duration was approximated as a product of the number of breastfed children and the longest breastfeeding duration. The longest and the total breastfeeding durations were categorized into none and tertiles above 0 months. Metabolic syndrome and cardiovascular risk factors (obesity, hypertension, dyslipidemia, and hyperglycemia) were defined as primary and secondary outcomes, respectively. Associations between breastfeeding history and metabolic syndrome or each cardiovascular risk factor were assessed using multivariable unconditional logistic regression analysis. Among a total of 11,118 women, 10,432 (93.8%) had ever breastfed, and 1,236 (11.1%) had metabolic syndrome. In participants aged <55 years, an inverse dose-response relationship was found between the number of breastfed children and the prevalence of metabolic syndrome; multivariable-adjusted odds ratios for 1, 2, 3, and ≥4 breastfed children were 0.60 (95% confidence interval [CI]: 0.31 to 1.17), 0.50 (95% CI: 0.29 to 0.87), 0.44 (95% CI: 0.24 to 0.84), and 0.35 (95% CI: 0.14 to 0.89), respectively. The longest and total breastfeeding durations of longer than 0 months were also associated with lower odds of metabolic syndrome relative to no breastfeeding history in participants aged <55 years. In contrast, all measures of breastfeeding history were not significantly associated with metabolic syndrome and cardiovascular risk factors in participants aged ≥55 years old. Breastfeeding history may be related to lower prevalence of metabolic syndrome in middle-aged parous women."},"publication_date":"2021-12-27","publication_name":{"en":"PLoS ONE","ja":"PLoS ONE"},"volume":"Vol.17","number":"No.1","starting_page":"e0262252","ending_page":"e0262252","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1371/journal.pone.0262252"],"issn":["1932-6203"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116990","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/34980592","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383792","label":"url"}],"paper_title":{"en":"Effect of the interaction between physical activity and estimated macronutrient intake on HbA1c: population-based cross-sectional and longitudinal studies","ja":"Effect of the interaction between physical activity and estimated macronutrient intake on HbA1c: population-based cross-sectional and longitudinal studies"},"authors":{"en":[{"name":"Furukawa Takuma"},{"name":"Nishida Yuichiro"},{"name":"Hara Megumi"},{"name":"Shimanoe Chisato"},{"name":"Koga Kayoko"},{"name":"Iwasaka Chiharu"},{"name":"Higaki Yasuki"},{"name":"Tanaka Keitaro"},{"name":"Nakashima Ryoko"},{"name":"Ikezaki Hiroaki"},{"name":"Hishida Asahi"},{"name":"Tamura Takashi"},{"name":"Kato Yasufumi"},{"name":"Tamada Yudai"},{"name":"Matsuo Kietaro"},{"name":"Ito Hidemi"},{"name":"Mikami Haruo"},{"name":"Kusakabe Miho"},{"name":"Ibusuki Rie"},{"name":"Shibuya Keiichi"},{"name":"Suzuki Sadao"},{"name":"Nakagawa-Senda Hiroko"},{"name":"Ozaki Etsuko"},{"name":"Matsui Daisuke"},{"name":"Kuriki Kiyonori"},{"name":"Nakamura Yasuyuki"},{"name":"Kadota, Aya"},{"name":"Arisawa Kokichi"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Takeuchi Kenji"},{"name":"Wakai Kenji"}],"ja":[{"name":"Furukawa Takuma"},{"name":"Nishida Yuichiro"},{"name":"Hara Megumi"},{"name":"Shimanoe Chisato"},{"name":"Koga Kayoko"},{"name":"Iwasaka Chiharu"},{"name":"Higaki Yasuki"},{"name":"Tanaka Keitaro"},{"name":"Nakashima Ryoko"},{"name":"Ikezaki Hiroaki"},{"name":"Hishida Asahi"},{"name":"Tamura Takashi"},{"name":"Kato Yasufumi"},{"name":"Tamada Yudai"},{"name":"Matsuo Kietaro"},{"name":"Ito Hidemi"},{"name":"Mikami Haruo"},{"name":"Kusakabe Miho"},{"name":"Ibusuki Rie"},{"name":"Shibuya Keiichi"},{"name":"Suzuki Sadao"},{"name":"Nakagawa-Senda Hiroko"},{"name":"Ozaki Etsuko"},{"name":"Matsui Daisuke"},{"name":"Kuriki Kiyonori"},{"name":"Nakamura Yasuyuki"},{"name":"Kadota, Aya"},{"name":"有澤 孝吉"},{"name":"勝浦-釜野 桜子"},{"name":"Takeuchi Kenji"},{"name":"Wakai Kenji"}]},"description":{"en":"Healthy diet and physical activity (PA) are essential for preventing type 2 diabetes, particularly, a combination of diet and PA. However, reports on interaction between PA and diet, especially from large epidemiological studies, are limited. We investigated the effect of interaction between PA and macronutrient intake on hemoglobin A1c (HbA1c) levels in the general population. We conducted a cross-sectional study of 55 469 men and women without diabetes who participated in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. A self-administered questionnaire ascertained PA and macronutrient intake (carbohydrate, fat, and protein). Multiple linear regression analyses were performed to adjust for confounding variables and examine the interactions. In addition, we conducted a longitudinal study during a 5-year period within a subcohort (n=6881) with accelerometer-assessed PA data. Overall, PA had a weak inverse association (β=-0.00033, p=0.049) and carbohydrate intake had a strong positive association (β=0.00393, p<0.001) with HbA1c. We observed a tendency of interactions between PA and carbohydrate or fat intake, but not protein intake, on HbA1c levels after adjusting for age, sex, study area, total energy intake, alcohol consumption, smoking, and medication for hypertension or hypercholesterolemia (P=0.054, 0.006, and 0.156, respectively). The inverse associations between PA and HbA1c level were more evident in participants with high-carbohydrate (or low-fat) intake than in participants with low-carbohydrate (or high-fat) intake. Although further adjustment for body mass index slightly attenuated the above interactions (P=0.098 for carbohydrate and 0.068 for fat), the associations between PA and HbA1c level in stratified analyses remained unchanged. Similar associations and interactions were reproduced in the longitudinal study. The present results suggest that the effect of PA on HbA1c levels is modified by intake of macronutrient composition.","ja":"Healthy diet and physical activity (PA) are essential for preventing type 2 diabetes, particularly, a combination of diet and PA. However, reports on interaction between PA and diet, especially from large epidemiological studies, are limited. We investigated the effect of interaction between PA and macronutrient intake on hemoglobin A1c (HbA1c) levels in the general population. We conducted a cross-sectional study of 55 469 men and women without diabetes who participated in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. A self-administered questionnaire ascertained PA and macronutrient intake (carbohydrate, fat, and protein). Multiple linear regression analyses were performed to adjust for confounding variables and examine the interactions. In addition, we conducted a longitudinal study during a 5-year period within a subcohort (n=6881) with accelerometer-assessed PA data. Overall, PA had a weak inverse association (β=-0.00033, p=0.049) and carbohydrate intake had a strong positive association (β=0.00393, p<0.001) with HbA1c. We observed a tendency of interactions between PA and carbohydrate or fat intake, but not protein intake, on HbA1c levels after adjusting for age, sex, study area, total energy intake, alcohol consumption, smoking, and medication for hypertension or hypercholesterolemia (P=0.054, 0.006, and 0.156, respectively). The inverse associations between PA and HbA1c level were more evident in participants with high-carbohydrate (or low-fat) intake than in participants with low-carbohydrate (or high-fat) intake. Although further adjustment for body mass index slightly attenuated the above interactions (P=0.098 for carbohydrate and 0.068 for fat), the associations between PA and HbA1c level in stratified analyses remained unchanged. Similar associations and interactions were reproduced in the longitudinal study. The present results suggest that the effect of PA on HbA1c levels is modified by intake of macronutrient composition."},"publication_date":"2021-12-07","publication_name":{"en":"BMJ Open Diabetes Research & Care","ja":"BMJ Open Diabetes Research & Care"},"volume":"Vol.10","number":"No.1","starting_page":"e002479","ending_page":"e002479","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1136/bmjdrc-2021-002479"],"issn":["2052-4897"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/35031776","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=383016","label":"url"}],"paper_title":{"en":"The association of reproductive history with hypertension and obesity depending on menopausal status: the J-MICC Study","ja":"The association of reproductive history with hypertension and obesity depending on menopausal status: the J-MICC Study"},"authors":{"en":[{"name":"Ohashi Mizuki"},{"name":"Miura Katsuyuki"},{"name":"Takashima Naoyuki"},{"name":"Kadota Aya"},{"name":"Saito Yoshino"},{"name":"Tsuji Shunichiro"},{"name":"Murakami Takashi"},{"name":"Kadomatsu Yuka"},{"name":"Nagayoshi Mako"},{"name":"Hara Megumi"},{"name":"Tanaka Keitaro"},{"name":"Tamura Takashi"},{"name":"Hishida Asahi"},{"name":"Takezaki Toshiro"},{"name":"Shimoshikiryo Ippei"},{"name":"Ozaki Etsuko"},{"name":"Watanabe Isao"},{"name":"Suzuki Sadao"},{"name":"Watanabe Miki"},{"name":"Kuriki Kiyonori"},{"name":"Arisawa Kokichi"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Yamasaki Sho"},{"name":"Ikezaki Hiroaki"},{"name":"Oze Isao"},{"name":"Koyanagi N. Yuriko"},{"name":"Mikami Haruo"},{"name":"Nakamura Yohko"},{"name":"Takeuchi Kenji"},{"name":"Kita Yoshikuni"},{"name":"Wakai Kenji"}],"ja":[{"name":"Ohashi Mizuki"},{"name":"Miura Katsuyuki"},{"name":"Takashima Naoyuki"},{"name":"Kadota Aya"},{"name":"Saito Yoshino"},{"name":"Tsuji Shunichiro"},{"name":"Murakami Takashi"},{"name":"Kadomatsu Yuka"},{"name":"Nagayoshi Mako"},{"name":"Hara Megumi"},{"name":"Tanaka Keitaro"},{"name":"Tamura Takashi"},{"name":"Hishida Asahi"},{"name":"Takezaki Toshiro"},{"name":"Shimoshikiryo Ippei"},{"name":"Ozaki Etsuko"},{"name":"Watanabe Isao"},{"name":"Suzuki Sadao"},{"name":"Watanabe Miki"},{"name":"Kuriki Kiyonori"},{"name":"有澤 孝吉"},{"name":"勝浦-釜野 桜子"},{"name":"Yamasaki Sho"},{"name":"Ikezaki Hiroaki"},{"name":"Oze Isao"},{"name":"Koyanagi N. Yuriko"},{"name":"Mikami Haruo"},{"name":"Nakamura Yohko"},{"name":"Takeuchi Kenji"},{"name":"Kita Yoshikuni"},{"name":"Wakai Kenji"}]},"description":{"en":"Previous studies have reported that the number of pregnancies and childbirths affected the risk of cardiovascular diseases (CVDs). However, the influence of reproductive history on hypertension and obesity, which are important risk factors for CVDs, is still unclear. Moreover, this association may vary depending on menopausal status. We evaluated the association of reproductive history with hypertension and obesity using a large cross-sectional dataset from the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study). At the baseline survey, physical data, blood samples, and self-reported health questionnaires were collected. Participants with insufficient data were excluded, and 24,558 women from eight study regions were included in this study. Logistic regression analysis was conducted to evaluate the association of reproductive history with hypertension and obesity using multivariable-adjusted odds ratios. In premenopausal women, childbirth showed a generally protective effect on hypertension but not on obesity. In postmenopausal women, childbirth was positively associated with obesity and hypertension but not with hypertension after adjusting for BMI. In conclusion, reproductive history was associated with hypertension and obesity in a large Japanese population, and this association differed between premenopausal and postmenopausal women.","ja":"Previous studies have reported that the number of pregnancies and childbirths affected the risk of cardiovascular diseases (CVDs). However, the influence of reproductive history on hypertension and obesity, which are important risk factors for CVDs, is still unclear. Moreover, this association may vary depending on menopausal status. We evaluated the association of reproductive history with hypertension and obesity using a large cross-sectional dataset from the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study). At the baseline survey, physical data, blood samples, and self-reported health questionnaires were collected. Participants with insufficient data were excluded, and 24,558 women from eight study regions were included in this study. Logistic regression analysis was conducted to evaluate the association of reproductive history with hypertension and obesity using multivariable-adjusted odds ratios. In premenopausal women, childbirth showed a generally protective effect on hypertension but not on obesity. In postmenopausal women, childbirth was positively associated with obesity and hypertension but not with hypertension after adjusting for BMI. In conclusion, reproductive history was associated with hypertension and obesity in a large Japanese population, and this association differed between premenopausal and postmenopausal women."},"publication_date":"2021-11-10","publication_name":{"en":"Hypertension Research","ja":"Hypertension Research"},"volume":"Vol.45","number":"No.4","starting_page":"708","ending_page":"714","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1038/s41440-021-00820-0"],"issn":["1348-4214"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/117198","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/34976669","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85117937322&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=382785","label":"url"}],"paper_title":{"en":"Association of skipping breakfast and short sleep duration with the prevalence of metabolic syndrome in the general Japanese population: baseline data from the Japan Multi-Institutional Collaborative Cohort Study","ja":"Association of skipping breakfast and short sleep duration with the prevalence of metabolic syndrome in the general Japanese population: baseline data from the Japan Multi-Institutional Collaborative Cohort Study"},"authors":{"en":[{"name":"Katsuura-Kamano Sakurako"},{"name":"Arisawa Kokichi"},{"name":"Uemura Hirokazu"},{"name":"Nguyen Van Tien"},{"name":"Takezaki Toshiro"},{"name":"Ibusuki Rie"},{"name":"Suzuki Sadao"},{"name":"Otani Takahiro"},{"name":"Okada Rieko"},{"name":"Kubo Yoko"},{"name":"Tamura Takashi"},{"name":"Hishida Asahi"},{"name":"Koyama Teruhide"},{"name":"Matsui Daisuke"},{"name":"Kuriki Kiyonori"},{"name":"Takashima Naoyuki"},{"name":"Miyagawa Naoko"},{"name":"Ikezaki Hiroaki"},{"name":"Matsumoto Yuji"},{"name":"Nishida Yuichiro"},{"name":"Shimanoe Chisato"},{"name":"Oze Isao"},{"name":"Matsuo Keitaro"},{"name":"Mikami Haruo"},{"name":"Kusakabe Miho"},{"name":"Takeuchi Kenji"},{"name":"Wakai Kenji"},{"name":"Study (J-MICC) Cohort Collaborative Multi-Institutional Japan the"}],"ja":[{"name":"勝浦-釜野 桜子"},{"name":"有澤 孝吉"},{"name":"上村 浩一"},{"name":"NGUYEN TIEN VAN"},{"name":"Takezaki Toshiro"},{"name":"Ibusuki Rie"},{"name":"Suzuki Sadao"},{"name":"Otani Takahiro"},{"name":"Okada Rieko"},{"name":"Kubo Yoko"},{"name":"Tamura Takashi"},{"name":"Hishida Asahi"},{"name":"Koyama Teruhide"},{"name":"Matsui Daisuke"},{"name":"Kuriki Kiyonori"},{"name":"Takashima Naoyuki"},{"name":"Miyagawa Naoko"},{"name":"Ikezaki Hiroaki"},{"name":"Matsumoto Yuji"},{"name":"Nishida Yuichiro"},{"name":"Shimanoe Chisato"},{"name":"Oze Isao"},{"name":"Matsuo Keitaro"},{"name":"Mikami Haruo"},{"name":"Kusakabe Miho"},{"name":"Takeuchi Kenji"},{"name":"Wakai Kenji"},{"name":"Study (J-MICC) Cohort Collaborative Multi-Institutional Japan the"}]},"description":{"en":"The purpose of the study was to investigate sex-specific associations of skipping breakfast and short sleep duration with metabolic syndrome (MetS) and their interaction. We analyzed baseline data of 14,907 men and 14,873 women aged 35-69 years, who participated in the Japan Multi-Institutional Collaborative Cohort Study from 2005. MetS was diagnosed using a modification of the National Cholesterol Education Program Adult Treatment Panel III revised definition (NCEP-R 2005), using body mass index instead of waist circumference. Breakfast consumption was classified into two categories: ≥6 days/week (consumers) or <6 days/week (skippers). Sleep duration was classified into three categories: <6h, 6 to <8 h, and ≥8 h/day. Multivariate logistic regression analysis was performed to estimate odds ratios (ORs) and 95 % confidence intervals (CIs) and examine the presence of interaction. In men, skipping breakfast and short sleep duration were independently associated with an increased prevalence of MetS (OR 1.26, 95%CI 1.12-1.42 and OR 1.28, 95%CI 1.12-1.45, respectively), obesity, and components of MetS. However, no significant interaction was observed between skipping breakfast and short sleep duration. In women, skipping breakfast and short sleep duration were associated with an increased prevalence of obesity, but not with MetS. These findings indicate that breakfast consumption and moderate sleep duration may be associated with a lower risk of MetS, particularly in men.","ja":"The purpose of the study was to investigate sex-specific associations of skipping breakfast and short sleep duration with metabolic syndrome (MetS) and their interaction. We analyzed baseline data of 14,907 men and 14,873 women aged 35-69 years, who participated in the Japan Multi-Institutional Collaborative Cohort Study from 2005. MetS was diagnosed using a modification of the National Cholesterol Education Program Adult Treatment Panel III revised definition (NCEP-R 2005), using body mass index instead of waist circumference. Breakfast consumption was classified into two categories: ≥6 days/week (consumers) or <6 days/week (skippers). Sleep duration was classified into three categories: <6h, 6 to <8 h, and ≥8 h/day. Multivariate logistic regression analysis was performed to estimate odds ratios (ORs) and 95 % confidence intervals (CIs) and examine the presence of interaction. In men, skipping breakfast and short sleep duration were independently associated with an increased prevalence of MetS (OR 1.26, 95%CI 1.12-1.42 and OR 1.28, 95%CI 1.12-1.45, respectively), obesity, and components of MetS. However, no significant interaction was observed between skipping breakfast and short sleep duration. In women, skipping breakfast and short sleep duration were associated with an increased prevalence of obesity, but not with MetS. These findings indicate that breakfast consumption and moderate sleep duration may be associated with a lower risk of MetS, particularly in men."},"publication_date":"2021-10-25","publication_name":{"en":"Preventive Medicine Reports","ja":"Preventive Medicine Reports"},"volume":"Vol.24","starting_page":"101613","ending_page":"101613","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.pmedr.2021.101613"],"issn":["2211-3355"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.jstage.jst.go.jp/article/jea/advpub/0/advpub_JE20210155/_pdf","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1390577818147551616/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=382236","label":"url"}],"paper_title":{"en":"Moderate-to-vigorous physical activity and sedentary behavior are independently associated with renal function: a cross-sectional study","ja":"Moderate-to-vigorous physical activity and sedentary behavior are independently associated with renal function: a cross-sectional study"},"authors":{"en":[{"name":"Hara Megumi"},{"name":"Nishida Yuichiro"},{"name":"Tanaka Keitaro"},{"name":"Shimanoe Chisato"},{"name":"Koga Kayoko"},{"name":"Furukawa Takuma"},{"name":"Higaki Yasuki"},{"name":"Shinchi Koichi"},{"name":"Ikezaki Hiroaki"},{"name":"Murata Masayuki"},{"name":"Takeuchi Kenji"},{"name":"Tamura Takashi"},{"name":"Hishida Asahi"},{"name":"Tsukamoto Mineko"},{"name":"Kadomatsu Yuka"},{"name":"Matsuo Keitaro"},{"name":"Oze Isao"},{"name":"Haruo Mikami"},{"name":"Miho Kusakabe"},{"name":"Takezaki Toshiro"},{"name":"Ibusuki Rie"},{"name":"Suzuki Sadao"},{"name":"Nakagawa-Senda Hiroko"},{"name":"Matsui Daisuke"},{"name":"Koyama Teruhide"},{"name":"Kuriki Kiyonori"},{"name":"Takashima Naoyuki"},{"name":"Nakamura Yasuyuki"},{"name":"Arisawa Kokichi"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Wakai Kenji"}],"ja":[{"name":"Hara Megumi"},{"name":"Nishida Yuichiro"},{"name":"Tanaka Keitaro"},{"name":"Shimanoe Chisato"},{"name":"Koga Kayoko"},{"name":"Furukawa Takuma"},{"name":"Higaki Yasuki"},{"name":"Shinchi Koichi"},{"name":"Ikezaki Hiroaki"},{"name":"Murata Masayuki"},{"name":"Takeuchi Kenji"},{"name":"Tamura Takashi"},{"name":"Hishida Asahi"},{"name":"Tsukamoto Mineko"},{"name":"Kadomatsu Yuka"},{"name":"Matsuo Keitaro"},{"name":"Oze Isao"},{"name":"Haruo Mikami"},{"name":"Miho Kusakabe"},{"name":"Takezaki Toshiro"},{"name":"Ibusuki Rie"},{"name":"Suzuki Sadao"},{"name":"Nakagawa-Senda Hiroko"},{"name":"Matsui Daisuke"},{"name":"Koyama Teruhide"},{"name":"Kuriki Kiyonori"},{"name":"Takashima Naoyuki"},{"name":"Nakamura Yasuyuki"},{"name":"有澤 孝吉"},{"name":"勝浦-釜野 桜子"},{"name":"Wakai Kenji"}]},"description":{"en":"
Background: Little is known about whether insufficient moderate-to-vigorous physical activity (MVPA) and longer sedentary behavior (SB) are independently associated with estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD), whether they interact with known risk factors for CKD, and the effect of replacing sedentary time with an equivalent duration of physical activity on kidney function.
Methods: We examined the cross-sectional association of MVPA and SB with eGFR and CKD in 66,603 Japanese cohort study in 14 areas from 2004 to 2013. MVPA and SB were estimated using a self-reported questionnaire, and CKD was defined as eGFR <60 mL/min/1.73 m2. Multiple linear regression analyses, logistic regression analyses, and an isotemporal substitution model were applied.
Results: After adjusting for potential confounders, higher MVPA and longer SB were independently associated with higher eGFR (P for trend MVPA <0.0001) and lower eGFR (P for trend SB <0.0001), and a lower odds ratio (OR) of CKD (adjusted OR of MVPA ≥20 MET·h/day, 0.76; 95% confidence interval [CI], 0.68-0.85 compared to MVPA <5 MET·h/day) and a higher OR of CKD (adjusted OR of SB ≥16 h/day, 1.81; 95% CI, 1.52-2.15 compared to SB <7 h/day), respectively. The negative association between MVPA and CKD was stronger in men, and significant interactions between sex and MVPA were detected. Replacing 1 hour of SB with 1 hour of physical activity was associated with about 3 to 4% lower OR of CKD.
Conclusions: These findings indicate that replacing SB with physical activity may benefit kidney function, especially in men, adding to the possible evidence on CKD prevention.
","ja":"Background: Little is known about whether insufficient moderate-to-vigorous physical activity (MVPA) and longer sedentary behavior (SB) are independently associated with estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD), whether they interact with known risk factors for CKD, and the effect of replacing sedentary time with an equivalent duration of physical activity on kidney function.
Methods: We examined the cross-sectional association of MVPA and SB with eGFR and CKD in 66,603 Japanese cohort study in 14 areas from 2004 to 2013. MVPA and SB were estimated using a self-reported questionnaire, and CKD was defined as eGFR <60 mL/min/1.73 m2. Multiple linear regression analyses, logistic regression analyses, and an isotemporal substitution model were applied.
Results: After adjusting for potential confounders, higher MVPA and longer SB were independently associated with higher eGFR (P for trend MVPA <0.0001) and lower eGFR (P for trend SB <0.0001), and a lower odds ratio (OR) of CKD (adjusted OR of MVPA ≥20 MET·h/day, 0.76; 95% confidence interval [CI], 0.68-0.85 compared to MVPA <5 MET·h/day) and a higher OR of CKD (adjusted OR of SB ≥16 h/day, 1.81; 95% CI, 1.52-2.15 compared to SB <7 h/day), respectively. The negative association between MVPA and CKD was stronger in men, and significant interactions between sex and MVPA were detected. Replacing 1 hour of SB with 1 hour of physical activity was associated with about 3 to 4% lower OR of CKD.
Conclusions: These findings indicate that replacing SB with physical activity may benefit kidney function, especially in men, adding to the possible evidence on CKD prevention.
"},"publication_date":"2021-09-24","publication_name":{"en":"Journal of Epidemiology","ja":"Journal of Epidemiology"},"volume":"Vol.33","number":"No.6","starting_page":"285","ending_page":"293","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2188/jea.je20210155"],"issn":["0917-5040"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/34565763","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=381812","label":"url"}],"paper_title":{"en":"Sex-specific Relationship between Stress Coping Strategies and All-Cause Mortality: Japan Multi-Institutional Collaborative Cohort Study","ja":"Sex-specific Relationship between Stress Coping Strategies and All-Cause Mortality: Japan Multi-Institutional Collaborative Cohort Study"},"authors":{"en":[{"name":"Nagayoshi Mako"},{"name":"Takeuchi Kenji"},{"name":"Tamada Yudai"},{"name":"Yasufumi Kato"},{"name":"Kubo Yoko"},{"name":"Okada Rieko"},{"name":"Tamura Takashi"},{"name":"Hishida Asahi"},{"name":"Otonari Jun"},{"name":"Ikezaki Hiroaki"},{"name":"Nishida Yuichiro"},{"name":"Shimanoe Chisato"},{"name":"Koyanagi N. Yuriko"},{"name":"Matsuo Keitaro"},{"name":"Haruo Mikami"},{"name":"Miho Kusakabe"},{"name":"Nishimoto Daisaku"},{"name":"Shibuya Keiichi"},{"name":"Suzuki Sadao"},{"name":"Nishiyama Takeshi"},{"name":"Ozaki Etsuko"},{"name":"Watanabe Isao"},{"name":"Kuriki Kiyonori"},{"name":"Takashima Naoyuki"},{"name":"Kadota Aya"},{"name":"Arisawa Kokichi"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Wakai Kenji"},{"name":"Study (J-MICC) Cohort Collaborative Multi-Institutional Japan the"}],"ja":[{"name":"Nagayoshi Mako"},{"name":"Takeuchi Kenji"},{"name":"Tamada Yudai"},{"name":"Yasufumi Kato"},{"name":"Kubo Yoko"},{"name":"Okada Rieko"},{"name":"Tamura Takashi"},{"name":"Hishida Asahi"},{"name":"Otonari Jun"},{"name":"Ikezaki Hiroaki"},{"name":"Nishida Yuichiro"},{"name":"Shimanoe Chisato"},{"name":"Koyanagi N. Yuriko"},{"name":"Matsuo Keitaro"},{"name":"Haruo Mikami"},{"name":"Miho Kusakabe"},{"name":"Nishimoto Daisaku"},{"name":"Shibuya Keiichi"},{"name":"Suzuki Sadao"},{"name":"Nishiyama Takeshi"},{"name":"Ozaki Etsuko"},{"name":"Watanabe Isao"},{"name":"Kuriki Kiyonori"},{"name":"Takashima Naoyuki"},{"name":"Kadota Aya"},{"name":"有澤 孝吉"},{"name":"勝浦-釜野 桜子"},{"name":"Wakai Kenji"},{"name":"Study (J-MICC) Cohort Collaborative Multi-Institutional Japan the"}]},"description":{"en":"Stress coping strategies are related to health outcomes. However, there is no clear evidence for sex differences between stress-coping strategies and mortality. We investigated the relationship between all-cause mortality and stress-coping strategies, focusing on sex differences among Japanese adults. A total of 79,580 individuals aged 35-69 years participated in the Japan Multi-Institutional Collaborative Cohort Study between 2004 and 2014 and were followed up for mortality. The frequency of use of the five coping strategies was assessed using a questionnaire. Sex-specific, multivariable-adjusted hazard ratios (HRs) for using each coping strategy \"sometimes,\" and \"often/very often\" (versus \"very few\" use) were computed for all-cause mortality. Furthermore, relationships were analyzed in specific follow-up periods when the proportion assumption was violated. During the follow-up (median: 8.5 years), 1,861 mortalities were recorded. In women, three coping strategies were related to lower total mortality. The HRs (95% confidence intervals) for \"sometimes\" were 0.81 (0.67-0.97) for emotional expression, 0.79 (0.66-0.95) for emotional support-seeking, and 0.80 (0.66-0.98) for disengagement. Men who \"sometimes\" used emotional expression and sometimes or often used problem-solving and positive reappraisal had a 15-41% lower HRs for all-cause mortality. However, those relationships were dependent on the follow-up period. There was evidence that sex modified the relationships between emotional support-seeking and all-cause mortality (p for interaction = 0.03). In a large Japanese population, selected coping strategies were associated with all-cause mortality. The relationship of emotional support-seeking was different between men and women.","ja":"Stress coping strategies are related to health outcomes. However, there is no clear evidence for sex differences between stress-coping strategies and mortality. We investigated the relationship between all-cause mortality and stress-coping strategies, focusing on sex differences among Japanese adults. A total of 79,580 individuals aged 35-69 years participated in the Japan Multi-Institutional Collaborative Cohort Study between 2004 and 2014 and were followed up for mortality. The frequency of use of the five coping strategies was assessed using a questionnaire. Sex-specific, multivariable-adjusted hazard ratios (HRs) for using each coping strategy \"sometimes,\" and \"often/very often\" (versus \"very few\" use) were computed for all-cause mortality. Furthermore, relationships were analyzed in specific follow-up periods when the proportion assumption was violated. During the follow-up (median: 8.5 years), 1,861 mortalities were recorded. In women, three coping strategies were related to lower total mortality. The HRs (95% confidence intervals) for \"sometimes\" were 0.81 (0.67-0.97) for emotional expression, 0.79 (0.66-0.95) for emotional support-seeking, and 0.80 (0.66-0.98) for disengagement. Men who \"sometimes\" used emotional expression and sometimes or often used problem-solving and positive reappraisal had a 15-41% lower HRs for all-cause mortality. However, those relationships were dependent on the follow-up period. There was evidence that sex modified the relationships between emotional support-seeking and all-cause mortality (p for interaction = 0.03). In a large Japanese population, selected coping strategies were associated with all-cause mortality. The relationship of emotional support-seeking was different between men and women."},"publication_date":"2021-09-08","publication_name":{"en":"Journal of Epidemiology","ja":"Journal of Epidemiology"},"languages":["eng"],"referee":true,"identifiers":{"doi":["10.2188/jea.JE20210220"],"issn":["1349-9092"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116719","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/34440216","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=381287","label":"url"}],"paper_title":{"en":"A Proposal For Practical Diagnosis Of Renal Hypouricemia: Evidenced From Genetic Studies Of Nonfunctional Variants Of URAT1/SLC22A12 Among 30,685 Japanese Individuals","ja":"A Proposal For Practical Diagnosis Of Renal Hypouricemia: Evidenced From Genetic Studies Of Nonfunctional Variants Of URAT1/SLC22A12 Among 30,685 Japanese Individuals"},"authors":{"en":[{"name":"Kawamura Yusuke"},{"name":"Nakayama Akiyoshi"},{"name":"Shimizu Seiko"},{"name":"Toyoda Yu"},{"name":"Nishida Yuichiro"},{"name":"Hishida Asahi"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Shibuya Kenichi"},{"name":"Tamura Takashi"},{"name":"Kawaguchi Makoto"},{"name":"Suzuki Satoko"},{"name":"Iwasawa Satoko"},{"name":"Nakashima Hiroshi"},{"name":"Ibusuki Rie"},{"name":"Uemura Hirokazu"},{"name":"Hara Megumi"},{"name":"Takeuchi Kenji"},{"name":"Takada Tappei"},{"name":"Tsunoda Masashi"},{"name":"Arisawa Kokichi"},{"name":"Takezaki Toshiro"},{"name":"Tanaka Keitaro"},{"name":"Ichida Kimiyoshi"},{"name":"Wakai Kenji"},{"name":"Shinomiya Nariyoshi"},{"name":"Matsuo Hirotaka"}],"ja":[{"name":"Kawamura Yusuke"},{"name":"Nakayama Akiyoshi"},{"name":"Shimizu Seiko"},{"name":"Toyoda Yu"},{"name":"Nishida Yuichiro"},{"name":"Hishida Asahi"},{"name":"勝浦-釜野 桜子"},{"name":"Shibuya Kenichi"},{"name":"Tamura Takashi"},{"name":"Kawaguchi Makoto"},{"name":"Suzuki Satoko"},{"name":"Iwasawa Satoko"},{"name":"Nakashima Hiroshi"},{"name":"Ibusuki Rie"},{"name":"上村 浩一"},{"name":"Hara Megumi"},{"name":"Takeuchi Kenji"},{"name":"Takada Tappei"},{"name":"Tsunoda Masashi"},{"name":"有澤 孝吉"},{"name":"Takezaki Toshiro"},{"name":"Tanaka Keitaro"},{"name":"Ichida Kimiyoshi"},{"name":"Wakai Kenji"},{"name":"Shinomiya Nariyoshi"},{"name":"Matsuo Hirotaka"}]},"description":{"en":"Renal hypouricemia (RHUC) is characterized by a low serum uric acid (SUA) level and high fractional excretion of uric acid (FE). Further studies on FE in hypouricemic individuals are needed for a more accurate diagnosis of RHUC. In 30,685 Japanese health-examination participants, we genotyped the two most common nonfunctional variants of (NFV-), W258X (rs121907892) and R90H (rs121907896), in 1040 hypouricemic individuals (SUA ≤ 3.0 mg/dL) and 2240 individuals with FE data. The effects of NFV- on FE and SUA were also investigated using linear and multiple regression analyses. Frequency of hypouricemic individuals (SUA ≤ 3.0 mg/dL) was 0.97% (male) and 6.94% (female) among 30,685 participants. High frequencies of those having at least one allele of NFV- were observed in 1040 hypouricemic individuals. Furthermore, NFV- significantly increased FE and decreased SUA, enabling FE and SUA levels to be estimated. Conversely, FE and SUA data of hypouricemic individuals are revealed to be useful to predict the number of NFV-. Our findings reveal that specific patterns of FE and SUA data assist with predicting the number of nonfunctional variants of causative genes for RHUC, and can also be useful for practical diagnosis of RHUC even before genetic tests.","ja":"Renal hypouricemia (RHUC) is characterized by a low serum uric acid (SUA) level and high fractional excretion of uric acid (FE). Further studies on FE in hypouricemic individuals are needed for a more accurate diagnosis of RHUC. In 30,685 Japanese health-examination participants, we genotyped the two most common nonfunctional variants of (NFV-), W258X (rs121907892) and R90H (rs121907896), in 1040 hypouricemic individuals (SUA ≤ 3.0 mg/dL) and 2240 individuals with FE data. The effects of NFV- on FE and SUA were also investigated using linear and multiple regression analyses. Frequency of hypouricemic individuals (SUA ≤ 3.0 mg/dL) was 0.97% (male) and 6.94% (female) among 30,685 participants. High frequencies of those having at least one allele of NFV- were observed in 1040 hypouricemic individuals. Furthermore, NFV- significantly increased FE and decreased SUA, enabling FE and SUA levels to be estimated. Conversely, FE and SUA data of hypouricemic individuals are revealed to be useful to predict the number of NFV-. Our findings reveal that specific patterns of FE and SUA data assist with predicting the number of nonfunctional variants of causative genes for RHUC, and can also be useful for practical diagnosis of RHUC even before genetic tests."},"publication_date":"2021-08-09","publication_name":{"en":"Biomedicines","ja":"Biomedicines"},"volume":"Vol.9","number":"No.8","languages":["eng"],"referee":true,"identifiers":{"doi":["10.3390/biomedicines9081012"],"issn":["2227-9059"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/118908","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/34421081","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=381286","label":"url"}],"paper_title":{"en":"Population-Based Impact of Smoking, Drinking, and Genetic Factors on HDL-Cholesterol Levels in J-MICC Study Participants","ja":"Population-Based Impact of Smoking, Drinking, and Genetic Factors on HDL-Cholesterol Levels in J-MICC Study Participants"},"authors":{"en":[{"name":"Nindita Yora"},{"name":"Nakatochi Masahiro"},{"name":"Ibusuki Rie"},{"name":"Shimoshikiryo Ippei"},{"name":"Nishimoto Daisaku"},{"name":"Shimatani Keiichi"},{"name":"Takezaki Toshiro"},{"name":"Ikezaki Hiroaki"},{"name":"Murata Masayuki"},{"name":"Hara Megumi"},{"name":"Nishida Yuichiro"},{"name":"Tamura Takashi"},{"name":"Hishida Asahi"},{"name":"Nagayoshi Mako"},{"name":"Okada Rieko"},{"name":"Matsuo Keitaro"},{"name":"Ito Hidemi"},{"name":"Mikami Haruo"},{"name":"Nakamura Yohko"},{"name":"Otani Takahiro"},{"name":"Suzuki Sadao"},{"name":"Koyama Teruhide"},{"name":"Ozaki Etsuko"},{"name":"Kuriki Kiyonori"},{"name":"Takashima Naoyuki"},{"name":"Miyagawa Naoko"},{"name":"Arisawa Kokichi"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Momozawa Yukihide"},{"name":"Kubo Michiaki"},{"name":"Takeuchi Kenji"},{"name":"Wakai Kenji"},{"name":"Group Study Cohort Collaborative Multi-Institutional Japan the"}],"ja":[{"name":"Nindita Yora"},{"name":"Nakatochi Masahiro"},{"name":"Ibusuki Rie"},{"name":"Shimoshikiryo Ippei"},{"name":"Nishimoto Daisaku"},{"name":"Shimatani Keiichi"},{"name":"Takezaki Toshiro"},{"name":"Ikezaki Hiroaki"},{"name":"Murata Masayuki"},{"name":"Hara Megumi"},{"name":"Nishida Yuichiro"},{"name":"Tamura Takashi"},{"name":"Hishida Asahi"},{"name":"Nagayoshi Mako"},{"name":"Okada Rieko"},{"name":"Matsuo Keitaro"},{"name":"Ito Hidemi"},{"name":"Mikami Haruo"},{"name":"Nakamura Yohko"},{"name":"Otani Takahiro"},{"name":"Suzuki Sadao"},{"name":"Koyama Teruhide"},{"name":"Ozaki Etsuko"},{"name":"Kuriki Kiyonori"},{"name":"Takashima Naoyuki"},{"name":"Miyagawa Naoko"},{"name":"有澤 孝吉"},{"name":"勝浦-釜野 桜子"},{"name":"Momozawa Yukihide"},{"name":"Kubo Michiaki"},{"name":"Takeuchi Kenji"},{"name":"Wakai Kenji"},{"name":"Group Study Cohort Collaborative Multi-Institutional Japan the"}]},"description":{"en":"Environmental and genetic factors are suggested to exhibit factor-based association with HDL-cholesterol (HDL-C) levels. However, the population-based effects of environmental and genetic factors have not been compared clearly. We conducted a cross-sectional study using data from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study to evaluate the population-based impact of smoking, drinking, and genetic factors on low HDL-C. Data from 11,498 men and women aged 35-69 years were collected for a genome-wide association study (GWAS). Sixty-five HDL-C-related SNPs with genome-wide significance (P < 5 × 10) were selected from the GWAS catalog, and seven representative SNPs were defined, and the population-based impact was estimated using population attributable fraction (PAF). We found that smoking, drinking, daily activity, habitual exercise, egg intake, BMI, age, sex and the SNPs CETP rs3764261, APOA5 rs662799, LIPC rs1800588, LPL rs328, ABCA1 rs2575876, LIPG rs3786247, and APOE rs429358 were associated with HDL-C levels. The gene-environmental interactions on smoking and drinking were not statistically significant. The PAF for low HDL-C was the highest in men (63.2%) and in rs3764261 (31.5%) of the genetic factors, and the PAFs of smoking and drinking were 23.1% and 41.8%, respectively. The present study showed that the population-based impact of genomic factor CETP rs3764261 for low HDL-C was higher than that of smoking and lower than that of drinking.","ja":"Environmental and genetic factors are suggested to exhibit factor-based association with HDL-cholesterol (HDL-C) levels. However, the population-based effects of environmental and genetic factors have not been compared clearly. We conducted a cross-sectional study using data from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study to evaluate the population-based impact of smoking, drinking, and genetic factors on low HDL-C. Data from 11,498 men and women aged 35-69 years were collected for a genome-wide association study (GWAS). Sixty-five HDL-C-related SNPs with genome-wide significance (P < 5 × 10) were selected from the GWAS catalog, and seven representative SNPs were defined, and the population-based impact was estimated using population attributable fraction (PAF). We found that smoking, drinking, daily activity, habitual exercise, egg intake, BMI, age, sex and the SNPs CETP rs3764261, APOA5 rs662799, LIPC rs1800588, LPL rs328, ABCA1 rs2575876, LIPG rs3786247, and APOE rs429358 were associated with HDL-C levels. The gene-environmental interactions on smoking and drinking were not statistically significant. The PAF for low HDL-C was the highest in men (63.2%) and in rs3764261 (31.5%) of the genetic factors, and the PAFs of smoking and drinking were 23.1% and 41.8%, respectively. The present study showed that the population-based impact of genomic factor CETP rs3764261 for low HDL-C was higher than that of smoking and lower than that of drinking."},"publication_date":"2021-08-04","publication_name":{"en":"Journal of Epidemiology","ja":"Journal of Epidemiology"},"languages":["eng"],"referee":true,"identifiers":{"doi":["10.2188/jea.JE20210142"],"issn":["1349-9092"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116932","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=384072","label":"url"}],"paper_title":{"en":"A Genome-wide Association Study on Meat Consumption in a Japanese Population- The Japan Multi-Institutional Collaborative Cohort study","ja":"A Genome-wide Association Study on Meat Consumption in a Japanese Population- The Japan Multi-Institutional Collaborative Cohort study"},"authors":{"en":[{"name":"Yasuyuki Nakamura"},{"name":"Akira Narita"},{"name":"Yoichi Sutoh"},{"name":"Nahomi Imaeda"},{"name":"Chiho Goto"},{"name":"Kenji Matsui"},{"name":"Naoyuki Takashima"},{"name":"Aya Kadota"},{"name":"Katsuyuki Miura"},{"name":"Masahiro Nakatochi"},{"name":"Takashi Tamura"},{"name":"Asahi Hishida,"},{"name":"Ryoko Nakashima"},{"name":"Hiroaki Ikezaki"},{"name":"Megumi Hara"},{"name":"Yuichiro Nishida"},{"name":"Toshiro Takezaki"},{"name":"Rie Ibusuki"},{"name":"Isao Oze"},{"name":"Hidemi Ito"},{"name":"Nagato Kuriyama"},{"name":"Etsuko Ozaki"},{"name":"Haruo Mikami"},{"name":"Miho Kusakabe"},{"name":"Hiroko Nakagawa-Senda"},{"name":"Sadao Suzuki"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Arisawa Kokichi"},{"name":"Kiyonori Kuriki"},{"name":"Yukihide Momozawa"},{"name":"Michiaki Kubo"},{"name":"Kenji Takeuchi"},{"name":"Yoshikuni Kita"},{"name":"Kenji Wakai"}],"ja":[{"name":"Yasuyuki Nakamura"},{"name":"Akira Narita"},{"name":"Yoichi Sutoh"},{"name":"Nahomi Imaeda"},{"name":"Chiho Goto"},{"name":"Kenji Matsui"},{"name":"Naoyuki Takashima"},{"name":"Aya Kadota"},{"name":"Katsuyuki Miura"},{"name":"Masahiro Nakatochi"},{"name":"Takashi Tamura"},{"name":"Asahi Hishida,"},{"name":"Ryoko Nakashima"},{"name":"Hiroaki Ikezaki"},{"name":"Megumi Hara"},{"name":"Yuichiro Nishida"},{"name":"Toshiro Takezaki"},{"name":"Rie Ibusuki"},{"name":"Isao Oze"},{"name":"Hidemi Ito"},{"name":"Nagato Kuriyama"},{"name":"Etsuko Ozaki"},{"name":"Haruo Mikami"},{"name":"Miho Kusakabe"},{"name":"Hiroko Nakagawa-Senda"},{"name":"Sadao Suzuki"},{"name":"勝浦-釜野 桜子"},{"name":"有澤 孝吉"},{"name":"Kiyonori Kuriki"},{"name":"Yukihide Momozawa"},{"name":"Michiaki Kubo"},{"name":"Kenji Takeuchi"},{"name":"Yoshikuni Kita"},{"name":"Kenji Wakai"}]},"publication_date":"2021-07-13","publication_name":{"en":"Journal of Nutritional Science","ja":"Journal of Nutritional Science"},"volume":"Vol.10","number":"No.e61","starting_page":"1","ending_page":"9","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1017/jns.2021.49"],"issn":["2048-6790"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/117242","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/34121417","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=374806","label":"url"}],"paper_title":{"en":"Effect of Underlying Cardiometabolic Diseases on the Association Between Sedentary Time and All-cause Mortality in a Large Japanese Population: A Cohort Analysis Based on the J-MICC Study","ja":"Effect of Underlying Cardiometabolic Diseases on the Association Between Sedentary Time and All-cause Mortality in a Large Japanese Population: A Cohort Analysis Based on the J-MICC Study"},"authors":{"en":[{"name":"Koyama Teruhide"},{"name":"Ozaki Etsuko"},{"name":"Kuriyama Nagato"},{"name":"Tomida Satomi"},{"name":"Yoshida Tamami"},{"name":"Uehara Ritei"},{"name":"Tanaka Keitaro"},{"name":"Hara Megumi"},{"name":"Hishida Asahi"},{"name":"Okada Rieko"},{"name":"Kubo Yoko"},{"name":"Oze Isao"},{"name":"Koyanagi Yuriko"},{"name":"Mikami Haruo"},{"name":"Nakamura Yohko"},{"name":"Shimoshikiryo Ippei"},{"name":"Takezaki Toshiro"},{"name":"Suzuki Sadao"},{"name":"Otani Takahiro"},{"name":"Kuriki Kiyonori"},{"name":"Takashima Naoyuki"},{"name":"Kadota Aya"},{"name":"Arisawa Kokichi"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Ikezaki Hiroaki"},{"name":"Murata Masayuki"},{"name":"Takeuchi Kenji"},{"name":"Wakai Kenji"}],"ja":[{"name":"Koyama Teruhide"},{"name":"Ozaki Etsuko"},{"name":"Kuriyama Nagato"},{"name":"Tomida Satomi"},{"name":"Yoshida Tamami"},{"name":"Uehara Ritei"},{"name":"Tanaka Keitaro"},{"name":"Hara Megumi"},{"name":"Hishida Asahi"},{"name":"Okada Rieko"},{"name":"Kubo Yoko"},{"name":"Oze Isao"},{"name":"Koyanagi Yuriko"},{"name":"Mikami Haruo"},{"name":"Nakamura Yohko"},{"name":"Shimoshikiryo Ippei"},{"name":"Takezaki Toshiro"},{"name":"Suzuki Sadao"},{"name":"Otani Takahiro"},{"name":"Kuriki Kiyonori"},{"name":"Takashima Naoyuki"},{"name":"Kadota Aya"},{"name":"有澤 孝吉"},{"name":"勝浦-釜野 桜子"},{"name":"Ikezaki Hiroaki"},{"name":"Murata Masayuki"},{"name":"Takeuchi Kenji"},{"name":"Wakai Kenji"}]},"description":{"en":"Background This study aimed to determine the association between sedentary time and mortality with regard to leisure-time physical activity with or without cardiometabolic diseases such as hypertension, dyslipidemia, and diabetes mellitus. Methods and Results Using data from the J-MICC (Japan Multi-Institutional Collaborative Cohort) Study, 64 456 participants (29 022 men, 35 434 women) were analyzed. Hazard ratios (HRs) and 95% CIs were used to characterize the relative risk of all-cause mortality to evaluate its association with sedentary time (categorical variables: <5, 5 to <7, 7 to <9, ≥9 h/d and 2-hour increments in exposure) according to the self-reported hypertension, dyslipidemia, and diabetes mellitus using a Cox proportional hazards model. A total of 2257 participants died during 7.7 years of follow-up. The corresponding HRs for each 2-hour increment in sedentary time among participants with all factors, no factors, hypertension, dyslipidemia, and diabetes mellitus were 1.153 (95% CI, 1.114-1.194), 1.125 (95% CI, 1.074-1.179), 1.202 (95% CI, 1.129-1.279), 1.176 (95% CI, 1.087-1.273), and 1.272 (95% CI, 1.159-1.396), respectively. Furthermore, when analyzed according to the combined different factors (hypertension, dyslipidemia, and diabetes mellitus), HRs increased with each additional factor, and participants reporting all 3 conditions had the highest HR of 1.417 (95% CI, 1.162-1.728) independently of leisure-time metabolic equivalents. Conclusions The association between sedentary time and increased mortality is stronger among patients with hypertension, dyslipidemia, and diabetes mellitus regardless of leisure-time physical activity in a large Japanese population.","ja":"Background This study aimed to determine the association between sedentary time and mortality with regard to leisure-time physical activity with or without cardiometabolic diseases such as hypertension, dyslipidemia, and diabetes mellitus. Methods and Results Using data from the J-MICC (Japan Multi-Institutional Collaborative Cohort) Study, 64 456 participants (29 022 men, 35 434 women) were analyzed. Hazard ratios (HRs) and 95% CIs were used to characterize the relative risk of all-cause mortality to evaluate its association with sedentary time (categorical variables: <5, 5 to <7, 7 to <9, ≥9 h/d and 2-hour increments in exposure) according to the self-reported hypertension, dyslipidemia, and diabetes mellitus using a Cox proportional hazards model. A total of 2257 participants died during 7.7 years of follow-up. The corresponding HRs for each 2-hour increment in sedentary time among participants with all factors, no factors, hypertension, dyslipidemia, and diabetes mellitus were 1.153 (95% CI, 1.114-1.194), 1.125 (95% CI, 1.074-1.179), 1.202 (95% CI, 1.129-1.279), 1.176 (95% CI, 1.087-1.273), and 1.272 (95% CI, 1.159-1.396), respectively. Furthermore, when analyzed according to the combined different factors (hypertension, dyslipidemia, and diabetes mellitus), HRs increased with each additional factor, and participants reporting all 3 conditions had the highest HR of 1.417 (95% CI, 1.162-1.728) independently of leisure-time metabolic equivalents. Conclusions The association between sedentary time and increased mortality is stronger among patients with hypertension, dyslipidemia, and diabetes mellitus regardless of leisure-time physical activity in a large Japanese population."},"publication_date":"2021-04-09","publication_name":{"en":"Journal of the American Heart Association","ja":"Journal of the American Heart Association"},"volume":"Vol.10","number":"No.13","starting_page":"e018293","ending_page":"e018293","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1161/JAHA.120.018293"],"issn":["2047-9980"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116617","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/33796588","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=376349","label":"url"}],"paper_title":{"en":"Limiting the Pitch Count in Youth Baseball Pitchers Decreases Elbow Pain.","ja":"Limiting the Pitch Count in Youth Baseball Pitchers Decreases Elbow Pain."},"authors":{"en":[{"name":"Matsuura Tetsuya"},{"name":"Takata Yuki"},{"name":"Iwame Toshiyuki"},{"name":"Iwase Jyoji"},{"name":"Yokoyama Kenji"},{"name":"Takao Shoichiro"},{"name":"Nishio Susumu"},{"name":"Arisawa Kokichi"},{"name":"Sairyo Koichi"}],"ja":[{"name":"松浦 哲也"},{"name":"Takata Yuki"},{"name":"岩目 敏幸"},{"name":"岩瀬 穣志"},{"name":"横山 賢二"},{"name":"髙尾 正一郎"},{"name":"Nishio Susumu"},{"name":"有澤 孝吉"},{"name":"西良 浩一"}]},"description":{"en":"A pitch count limit of 70 pitches per day for baseball pitchers 12 years could be more protective against elbow pain and reduced flexion than a limit of 7 innings per day, but it may not be effective for reducing the risk of capitellar OCD.","ja":"A pitch count limit of 70 pitches per day for baseball pitchers 12 years could be more protective against elbow pain and reduced flexion than a limit of 7 innings per day, but it may not be effective for reducing the risk of capitellar OCD."},"publication_date":"2021-03-18","publication_name":{"en":"Orthopaedic Journal of Sports Medicine","ja":"Orthopaedic Journal of Sports Medicine"},"volume":"Vol.9","number":"No.3","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1177/2325967121989108"],"issn":["2325-9671"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=374230","label":"url"}],"paper_title":{"en":"A Genome-wide Association Study on Confection Consumption in a Japanese Population- The Japan Multi-Institutional Collaborative Cohort study","ja":"A Genome-wide Association Study on Confection Consumption in a Japanese Population- The Japan Multi-Institutional Collaborative Cohort study"},"authors":{"en":[{"name":"Suzuki Taro"},{"name":"Nakamura Yasuyuki"},{"name":"Doi Yukio"},{"name":"Narita Akira"},{"name":"Shimizu Atsushi"},{"name":"Imaeda Nahomi"},{"name":"Goto Chiho"},{"name":"Matsui Kenji"},{"name":"Kadota Aya"},{"name":"Miura Katsuyuki"},{"name":"Nakatochi Masahiro"},{"name":"Tanaka Keitaro"},{"name":"Hara Megumi"},{"name":"Ikezaki Hiroaki"},{"name":"Murata Masayuki"},{"name":"Takezaki Toshiro"},{"name":"Nishimoto Daisaku"},{"name":"Matsuo Keitaro"},{"name":"Oze Isao"},{"name":"Kuriyama Nagato"},{"name":"Ozaki Etsuko"},{"name":"Mikami Haruo"},{"name":"Nakamura Yohko"},{"name":"Watanabe Miki"},{"name":"Suzuki Sadao"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Arisawa Kokichi"},{"name":"Kuriki Kiyonori"},{"name":"Momozawa Yukihide"},{"name":"Kubo Michiaki"},{"name":"Takeuchi Kenji"},{"name":"Kita Yoshikuni"},{"name":"Wakai Kenji"}],"ja":[{"name":"Suzuki Taro"},{"name":"Nakamura Yasuyuki"},{"name":"Doi Yukio"},{"name":"Narita Akira"},{"name":"Shimizu Atsushi"},{"name":"Imaeda Nahomi"},{"name":"Goto Chiho"},{"name":"Matsui Kenji"},{"name":"Kadota Aya"},{"name":"Miura Katsuyuki"},{"name":"Nakatochi Masahiro"},{"name":"Tanaka Keitaro"},{"name":"Hara Megumi"},{"name":"Ikezaki Hiroaki"},{"name":"Murata Masayuki"},{"name":"Takezaki Toshiro"},{"name":"Nishimoto Daisaku"},{"name":"Matsuo Keitaro"},{"name":"Oze Isao"},{"name":"Kuriyama Nagato"},{"name":"Ozaki Etsuko"},{"name":"Mikami Haruo"},{"name":"Nakamura Yohko"},{"name":"Watanabe Miki"},{"name":"Suzuki Sadao"},{"name":"勝浦-釜野 桜子"},{"name":"有澤 孝吉"},{"name":"Kuriki Kiyonori"},{"name":"Momozawa Yukihide"},{"name":"Kubo Michiaki"},{"name":"Takeuchi Kenji"},{"name":"Kita Yoshikuni"},{"name":"Wakai Kenji"}]},"publication_date":"2021-02-26","publication_name":{"en":"British Journal of Nutrition","ja":"British Journal of Nutrition"},"languages":["eng"],"referee":true,"identifiers":{"doi":["10.1017/S0007114521000684"],"issn":["0007-1145"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://doi.org/10.2188/jea.JE20200540","label":"url"},{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/118054","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/33612706","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=374051","label":"url"}],"paper_title":{"en":"Assessing the relationship between high-sensitivity C-reactive protein and kidney function employing mendelian randomization in a Japanese community based J-MICC Study","ja":"Assessing the relationship between high-sensitivity C-reactive protein and kidney function employing mendelian randomization in a Japanese community based J-MICC Study"},"authors":{"en":[{"name":"Ryosuke Fujii"},{"name":"Asahi Hishida"},{"name":"Takeshi Nishiyama"},{"name":"Masahiro Nakatochi"},{"name":"Keitaro Matsuo"},{"name":"Hidemi Ito"},{"name":"Yuichiro Nishida"},{"name":"Chisato Shimanoe"},{"name":"Yasuyuki Nakamura"},{"name":"Tanvir Chowdhury Turin"},{"name":"Sadao Suzuki"},{"name":"Miki Watanabe"},{"name":"Rie Ibusuki"},{"name":"Toshiro Takezaki"},{"name":"Haruo Mikami"},{"name":"Yohko Nakamura"},{"name":"Hiroaki Ikezaki"},{"name":"Masayuki Murata"},{"name":"Kiyonori Kuriki"},{"name":"Nagato Kuriyama"},{"name":"Daisuke Matsui"},{"name":"Arisawa Kokichi"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Mineko Tsukamoto"},{"name":"Takashi Tamura"},{"name":"Yoko Kubo"},{"name":"Takaaki Kondo"},{"name":"Yukihide Momozawa"},{"name":"Michiaki Kubo"},{"name":"Kenji Takeuch"},{"name":"Kenji Wakai"},{"name":"J-MICC Study Group"}],"ja":[{"name":"Ryosuke Fujii"},{"name":"Asahi Hishida"},{"name":"Takeshi Nishiyama"},{"name":"Masahiro Nakatochi"},{"name":"Keitaro Matsuo"},{"name":"Hidemi Ito"},{"name":"Yuichiro Nishida"},{"name":"Chisato Shimanoe"},{"name":"Yasuyuki Nakamura"},{"name":"Tanvir Chowdhury Turin"},{"name":"Sadao Suzuki"},{"name":"Miki Watanabe"},{"name":"Rie Ibusuki"},{"name":"Toshiro Takezaki"},{"name":"Haruo Mikami"},{"name":"Yohko Nakamura"},{"name":"Hiroaki Ikezaki"},{"name":"Masayuki Murata"},{"name":"Kiyonori Kuriki"},{"name":"Nagato Kuriyama"},{"name":"Daisuke Matsui"},{"name":"有澤 孝吉"},{"name":"勝浦-釜野 桜子"},{"name":"Mineko Tsukamoto"},{"name":"Takashi Tamura"},{"name":"Yoko Kubo"},{"name":"Takaaki Kondo"},{"name":"Yukihide Momozawa"},{"name":"Michiaki Kubo"},{"name":"Kenji Takeuch"},{"name":"Kenji Wakai"},{"name":"J-MICC Study Group"}]},"description":{"en":"Inflammation is thought to be a risk factor for kidney disease. However, discussion is controversial whether inflammatory status is either a cause or an outcome of chronic kidney disease. We aimed to investigate the causal relationship between high-sensitivity C-reactive protein (hs-CRP) and estimated glomerular filtration rate (eGFR) using mendelian randomization (MR) approaches. A total of 10,521 participants of the Japan Multi-institutional Collaborative Cohort Study was analyzed in this study. We used two-sample MR approaches (the inverse-variance weighted (IVW), the weighted median (WM), and the MR-Egger method) to estimate the effect of genetically determined hs-CRP on kidney function. We selected four and three hs-CRP associated single nucleotide polymorphisms (SNPs) as two instrumental variables (IV): IV and IV, based on SNPs previously identified in European and Asian populations. IV and IV explained 3.4% and 3.9% of the variation in hs-CRP, respectively. Using the IV, genetically determined hs-CRP was not significantly associated with eGFR in the IVW and the WM methods (estimate per 1 unit increase in ln(hs-CRP), 95%CI: 0.000, -0.019 to 0.020 and -0.003, -0.019 to 0.014). For IV, we found similar results using the IVW and the WM methods (estimate, 95% CI: -0.005, -0.020 to 0.010 and -0.004, -0.020 to 0.012). The MR-Egger method also showed no causal relationships between hs-CRP and eGFR (IV: -0.008, -0.058 to 0.042; IV: 0.001, -0.036 to 0.036). Our two-sample MR analyses with different IVs did not support a causal effect of hs-CRP on eGFR.","ja":"Inflammation is thought to be a risk factor for kidney disease. However, discussion is controversial whether inflammatory status is either a cause or an outcome of chronic kidney disease. We aimed to investigate the causal relationship between high-sensitivity C-reactive protein (hs-CRP) and estimated glomerular filtration rate (eGFR) using mendelian randomization (MR) approaches. A total of 10,521 participants of the Japan Multi-institutional Collaborative Cohort Study was analyzed in this study. We used two-sample MR approaches (the inverse-variance weighted (IVW), the weighted median (WM), and the MR-Egger method) to estimate the effect of genetically determined hs-CRP on kidney function. We selected four and three hs-CRP associated single nucleotide polymorphisms (SNPs) as two instrumental variables (IV): IV and IV, based on SNPs previously identified in European and Asian populations. IV and IV explained 3.4% and 3.9% of the variation in hs-CRP, respectively. Using the IV, genetically determined hs-CRP was not significantly associated with eGFR in the IVW and the WM methods (estimate per 1 unit increase in ln(hs-CRP), 95%CI: 0.000, -0.019 to 0.020 and -0.003, -0.019 to 0.014). For IV, we found similar results using the IVW and the WM methods (estimate, 95% CI: -0.005, -0.020 to 0.010 and -0.004, -0.020 to 0.012). The MR-Egger method also showed no causal relationships between hs-CRP and eGFR (IV: -0.008, -0.058 to 0.042; IV: 0.001, -0.036 to 0.036). Our two-sample MR analyses with different IVs did not support a causal effect of hs-CRP on eGFR."},"publication_date":"2021-02-20","publication_name":{"en":"Journal of Epidemiology","ja":"Journal of Epidemiology"},"languages":["eng"],"referee":true,"identifiers":{"doi":["10.2188/jea.JE20200540"],"issn":["0917-5040"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/117822","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/33583934","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=373453","label":"url"}],"paper_title":{"en":"Association between nutrient patterns and fatty liver index: Baseline survey of the Japan Multi-Institutional Collaborative Cohort Study in Tokushima, Japan","ja":"Association between nutrient patterns and fatty liver index: Baseline survey of the Japan Multi-Institutional Collaborative Cohort Study in Tokushima, Japan"},"authors":{"en":[{"name":"Nguyen Tien Van"},{"name":"Arisawa Kokichi"},{"name":"Uemura Hirokazu"},{"name":"Imaeda Naomi"},{"name":"Goto Chiho"},{"name":"Katsuura-Kamano Sakurako"}],"ja":[{"name":"TIEN VAN NGUYEN"},{"name":"有澤 孝吉"},{"name":"上村 浩一"},{"name":"Imaeda Naomi"},{"name":"Goto Chiho"},{"name":"勝浦-釜野 桜子"}]},"description":{"en":"The fatty liver index (FLI) is a good non-invasive approach for fatty liver disease diagnosis. The objective of this study was to examine the associations of nutrient patterns with nonalcoholic fatty liver disease (NAFLD) in a Japanese population. A total of 1,588 subjects (789 men and 799 women) aged 35 to 69 years were recruited in the baseline survey of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study in Tokushima Prefecture. Factor analysis was applied to energy-adjusted intake of 21 nutrients, and nutrient patterns were extracted. Multiple logistic regression analysis was used to analyze the relationships between nutrient patterns and the high FLI category (60). Four nutrient patterns were extracted: Factor 1, vitamins, dietary fiber, iron and potassium pattern; Factor 2, fats and fat-soluble vitamins pattern; Factor 3, saturated fat, calcium, vitamin B and low carbohydrate pattern; and Factor 4, sodium, protein and vitamin D pattern. After adjustment for sex, age, and other potential confounding variables, higher Factor 1 scores were significantly associated with lower odds ratios of NAFLD (P for trend <0.05). Analysis of each component of FLI showed that there were significant inverse associations between Factor 1 scores and high body mass index and large waist circumference. The present findings suggest that a nutrient pattern rich in vitamins, fiber, iron, and potassium was associated with lower prevalence of NAFLD in a Japanese population. Obesity and abdominal obesity may be intermediate variables for the association between this nutrient pattern and NAFLD.","ja":"The fatty liver index (FLI) is a good non-invasive approach for fatty liver disease diagnosis. The objective of this study was to examine the associations of nutrient patterns with nonalcoholic fatty liver disease (NAFLD) in a Japanese population. A total of 1,588 subjects (789 men and 799 women) aged 35 to 69 years were recruited in the baseline survey of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study in Tokushima Prefecture. Factor analysis was applied to energy-adjusted intake of 21 nutrients, and nutrient patterns were extracted. Multiple logistic regression analysis was used to analyze the relationships between nutrient patterns and the high FLI category (60). Four nutrient patterns were extracted: Factor 1, vitamins, dietary fiber, iron and potassium pattern; Factor 2, fats and fat-soluble vitamins pattern; Factor 3, saturated fat, calcium, vitamin B and low carbohydrate pattern; and Factor 4, sodium, protein and vitamin D pattern. After adjustment for sex, age, and other potential confounding variables, higher Factor 1 scores were significantly associated with lower odds ratios of NAFLD (P for trend <0.05). Analysis of each component of FLI showed that there were significant inverse associations between Factor 1 scores and high body mass index and large waist circumference. The present findings suggest that a nutrient pattern rich in vitamins, fiber, iron, and potassium was associated with lower prevalence of NAFLD in a Japanese population. Obesity and abdominal obesity may be intermediate variables for the association between this nutrient pattern and NAFLD."},"publication_date":"2021-01-29","publication_name":{"en":"Journal of Epidemiology","ja":"Journal of Epidemiology"},"volume":"Vol.32","number":"No.8","starting_page":"376","ending_page":"383","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2188/jea.JE20200447"],"issn":["1349-9092"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116290","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/33506574","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=374097","label":"url"}],"paper_title":{"en":"Body mass index and colorectal cancer risk: a Mendelian randomization study","ja":"Body mass index and colorectal cancer risk: a Mendelian randomization study"},"authors":{"en":[{"name":"Suzuki Shiori"},{"name":"Goto Atsushi"},{"name":"Nakatochi Masahiro"},{"name":"Narita Akira"},{"name":"Yamaji Taiki"},{"name":"Sawada Norie"},{"name":"Katagiri Ryoko"},{"name":"Iwagami Masao"},{"name":"Hanyuda Akiko"},{"name":"Hachiya Tsuyoshi"},{"name":"Sutoh Yoichi"},{"name":"Oze Isao"},{"name":"Koyanagi Yuriko"},{"name":"Kasugai Yumiko"},{"name":"Taniyama Yukari"},{"name":"Ito Hidemi"},{"name":"Ikezaki Hiroaki"},{"name":"Nishida Yuichiro"},{"name":"Tamura Takashi"},{"name":"Mikami Haruo"},{"name":"Takezaki Toshiro"},{"name":"Suzuki Sadao"},{"name":"Ozaki Etsuko"},{"name":"Kuriki Kiyonori"},{"name":"Takashima Naoyuki"},{"name":"Arisawa Kokichi"},{"name":"Takeuchi Kenji"},{"name":"Tanno Kozo"},{"name":"Shimizu Atsushi"},{"name":"Tamiya Gen"},{"name":"Hozawa Atsushi"},{"name":"Kinoshita Kengo"},{"name":"Wakai Kenji Sasaki Makoto"},{"name":"Yamamoto Masayuki"},{"name":"Matsuo Keitaro"},{"name":"Tsugane Shoichiro"},{"name":"Iwasaki Motoki"}],"ja":[{"name":"Suzuki Shiori"},{"name":"Goto Atsushi"},{"name":"Nakatochi Masahiro"},{"name":"Narita Akira"},{"name":"Yamaji Taiki"},{"name":"Sawada Norie"},{"name":"Katagiri Ryoko"},{"name":"Iwagami Masao"},{"name":"Hanyuda Akiko"},{"name":"Hachiya Tsuyoshi"},{"name":"Sutoh Yoichi"},{"name":"Oze Isao"},{"name":"Koyanagi Yuriko"},{"name":"Kasugai Yumiko"},{"name":"Taniyama Yukari"},{"name":"Ito Hidemi"},{"name":"Ikezaki Hiroaki"},{"name":"Nishida Yuichiro"},{"name":"Tamura Takashi"},{"name":"Mikami Haruo"},{"name":"Takezaki Toshiro"},{"name":"Suzuki Sadao"},{"name":"Ozaki Etsuko"},{"name":"Kuriki Kiyonori"},{"name":"Takashima Naoyuki"},{"name":"有澤 孝吉"},{"name":"Takeuchi Kenji"},{"name":"Tanno Kozo"},{"name":"Shimizu Atsushi"},{"name":"Tamiya Gen"},{"name":"Hozawa Atsushi"},{"name":"Kinoshita Kengo"},{"name":"Wakai Kenji Sasaki Makoto"},{"name":"Yamamoto Masayuki"},{"name":"Matsuo Keitaro"},{"name":"Tsugane Shoichiro"},{"name":"Iwasaki Motoki"}]},"description":{"en":"Traditional observational studies have reported a positive association between higher body mass index (BMI) and the risk of colorectal cancer (CRC). However, evidence from other approaches to pursue the causal relationship between BMI and CRC is sparse. A two-sample Mendelian randomization (MR) study was undertaken using 68 single nucleotide polymorphisms (SNPs) from the Japanese genome-wide association study (GWAS) and 654 SNPs from the GWAS catalogue for BMI as sets of instrumental variables. For the analysis of SNP-BMI associations, we undertook a meta-analysis with 36 303 participants in the Japanese Consortium of Genetic Epidemiology studies (J-CGE), comprising normal populations. For the analysis of SNP-CRC associations, we utilized 7636 CRC cases and 37 141 controls from five studies in Japan, and undertook a meta-analysis. Mendelian randomization analysis of inverse-variance weighted method indicated that a one-unit (kg/m ) increase in genetically predicted BMI was associated with an odds ratio of 1.13 (95% confidence interval, 1.06-1.20; P value <.001) for CRC using the set of 68 SNPs, and an odds ratio of 1.07 (1.03-1.11, 0.001) for CRC using the set of 654 SNPs. Sensitivity analyses robustly showed increased odds ratios for CRC for every one-unit increase in genetically predicted BMI. Our MR analyses strongly support the evidence that higher BMI influences the risk of CRC. Although Asians are generally leaner than Europeans and North Americans, avoiding higher BMI seems to be important for the prevention of CRC in Asian populations.","ja":"Traditional observational studies have reported a positive association between higher body mass index (BMI) and the risk of colorectal cancer (CRC). However, evidence from other approaches to pursue the causal relationship between BMI and CRC is sparse. A two-sample Mendelian randomization (MR) study was undertaken using 68 single nucleotide polymorphisms (SNPs) from the Japanese genome-wide association study (GWAS) and 654 SNPs from the GWAS catalogue for BMI as sets of instrumental variables. For the analysis of SNP-BMI associations, we undertook a meta-analysis with 36 303 participants in the Japanese Consortium of Genetic Epidemiology studies (J-CGE), comprising normal populations. For the analysis of SNP-CRC associations, we utilized 7636 CRC cases and 37 141 controls from five studies in Japan, and undertook a meta-analysis. Mendelian randomization analysis of inverse-variance weighted method indicated that a one-unit (kg/m ) increase in genetically predicted BMI was associated with an odds ratio of 1.13 (95% confidence interval, 1.06-1.20; P value <.001) for CRC using the set of 68 SNPs, and an odds ratio of 1.07 (1.03-1.11, 0.001) for CRC using the set of 654 SNPs. Sensitivity analyses robustly showed increased odds ratios for CRC for every one-unit increase in genetically predicted BMI. Our MR analyses strongly support the evidence that higher BMI influences the risk of CRC. Although Asians are generally leaner than Europeans and North Americans, avoiding higher BMI seems to be important for the prevention of CRC in Asian populations."},"publication_date":"2021-01-24","publication_name":{"en":"Cancer Science","ja":"Cancer Science"},"volume":"Vol.112","number":"No.4","starting_page":"1579","ending_page":"1588","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1111/cas.14824"],"issn":["1349-7006"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://cir.nii.ac.jp/crid/1390009225620221952/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=374596","label":"url"}],"paper_title":{"en":"Genome-wide association study of serum PSA levels based on 1000Genomes-imputed data in Japanese: the J-MICC Study","ja":"Genome-wide association study of serum PSA levels based on 1000Genomes-imputed data in Japanese: the J-MICC Study"},"authors":{"en":[{"name":"Asahi Hishida"},{"name":"Masahiro Nakatochi"},{"name":"Takashi Tamura"},{"name":"Mako Nagayoshi"},{"name":"Rieko Okada"},{"name":"Yoko Kubo"},{"name":"Mineko Tsukamoto"},{"name":"Yuka Kadomatsu"},{"name":"Sadao Suzuki"},{"name":"Takeshi Nishiyama"},{"name":"Nagato Kuriyama"},{"name":"Isao Watanabe"},{"name":"Toshiro Takezaki"},{"name":"Daisaku Nishimoto"},{"name":"Kiyonori Kuriki"},{"name":"Arisawa Kokichi"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Haruo Mikami"},{"name":"Miho Kusakabe"},{"name":"Isao Oze"},{"name":"Yuriko Koyanagi"},{"name":"Yasuyuki Nakamura"},{"name":"Aya Kadota"},{"name":"Chisato Shimanoe"},{"name":"Keitaro Tanaka"},{"name":"Hiroaki Ikezaki"},{"name":"Masayuki Murata"},{"name":"Michiaki Kubo"},{"name":"Yukihide Momozawa"},{"name":"Kenji Takeuchi"},{"name":"Kenji Wakai"}],"ja":[{"name":"Asahi Hishida"},{"name":"Masahiro Nakatochi"},{"name":"Takashi Tamura"},{"name":"Mako Nagayoshi"},{"name":"Rieko Okada"},{"name":"Yoko Kubo"},{"name":"Mineko Tsukamoto"},{"name":"Yuka Kadomatsu"},{"name":"Sadao Suzuki"},{"name":"Takeshi Nishiyama"},{"name":"Nagato Kuriyama"},{"name":"Isao Watanabe"},{"name":"Toshiro Takezaki"},{"name":"Daisaku Nishimoto"},{"name":"Kiyonori Kuriki"},{"name":"有澤 孝吉"},{"name":"勝浦-釜野 桜子"},{"name":"Haruo Mikami"},{"name":"Miho Kusakabe"},{"name":"Isao Oze"},{"name":"Yuriko Koyanagi"},{"name":"Yasuyuki Nakamura"},{"name":"Aya Kadota"},{"name":"Chisato Shimanoe"},{"name":"Keitaro Tanaka"},{"name":"Hiroaki Ikezaki"},{"name":"Masayuki Murata"},{"name":"Michiaki Kubo"},{"name":"Yukihide Momozawa"},{"name":"Kenji Takeuchi"},{"name":"Kenji Wakai"}]},"publication_date":"2021","publication_name":{"en":"Nagoya Journal of Medical Science","ja":"Nagoya Journal of Medical Science"},"volume":"Vol.83","number":"No.1","starting_page":"183","ending_page":"193","languages":["eng"],"referee":true,"identifiers":{"doi":["10.18999/nagjms.83.1.183"],"issn":["0027-7622"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/33281188","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85097206785&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=372895","label":"url"}],"paper_title":{"en":"A genome-wide association study in Japanese identified one variant associated with a preference for a Japanese dietary pattern","ja":"A genome-wide association study in Japanese identified one variant associated with a preference for a Japanese dietary pattern"},"authors":{"en":[{"name":"Suzuki H"},{"name":"Nakamura Y"},{"name":"Matsuo K"},{"name":"Imaeda N"},{"name":"Goto C"},{"name":"Narita A"},{"name":"Shimizu A"},{"name":"Takashima N"},{"name":"Matsui K"},{"name":"Miura K"},{"name":"Nakatochi M"},{"name":"Hishida A"},{"name":"Tamura T"},{"name":"Kadomatsu Y"},{"name":"Okada R"},{"name":"Nishida Y"},{"name":"Shimanoe C"},{"name":"Nishimoto D"},{"name":"Takezaki T"},{"name":"Oze I"},{"name":"Ito H"},{"name":"Ikezaki H"},{"name":"Murata M"},{"name":"Matsui D"},{"name":"Ozaki E"},{"name":"Mikami H"},{"name":"Nakamura Y"},{"name":"Suzuki S"},{"name":"Watanabe M"},{"name":"Arisawa Kokichi"},{"name":"Uemura H"},{"name":"Kuriki K"},{"name":"Momozawa Y"},{"name":"Kubo M"},{"name":"Kita Y"},{"name":"Takeuchi K"},{"name":"Wakai K"}],"ja":[{"name":"Suzuki H"},{"name":"Nakamura Y"},{"name":"Matsuo K"},{"name":"Imaeda N"},{"name":"Goto C"},{"name":"Narita A"},{"name":"Shimizu A"},{"name":"Takashima N"},{"name":"Matsui K"},{"name":"Miura K"},{"name":"Nakatochi M"},{"name":"Hishida A"},{"name":"Tamura T"},{"name":"Kadomatsu Y"},{"name":"Okada R"},{"name":"Nishida Y"},{"name":"Shimanoe C"},{"name":"Nishimoto D"},{"name":"Takezaki T"},{"name":"Oze I"},{"name":"Ito H"},{"name":"Ikezaki H"},{"name":"Murata M"},{"name":"Matsui D"},{"name":"Ozaki E"},{"name":"Mikami H"},{"name":"Nakamura Y"},{"name":"Suzuki S"},{"name":"Watanabe M"},{"name":"有澤 孝吉"},{"name":"Uemura H"},{"name":"Kuriki K"},{"name":"Momozawa Y"},{"name":"Kubo M"},{"name":"Kita Y"},{"name":"Takeuchi K"},{"name":"Wakai K"}]},"description":{"en":"Individual eating habits may be influenced by genetic factors, in addition to environmental factors. Previous studies suggested that adherence to Japanese food patterns was associated with a decreased risk of all-cause and cardiovascular disease mortality. We conducted a genome-wide association study (GWAS) in a Japanese population to find genetic variations that affect adherence to a Japanese food pattern. We analyzed GWAS data using 14,079 participants from the Japan Multi-Institutional Collaborative Cohort study. We made a Japanese food score based on six food groups. Association of the imputed variants with the Japanese food score was performed by linear regression analysis with adjustments for age, sex, total energy intake, alcohol intake (g/day), and principal components 1-10 omitting variants in the major histocompatibility region. We found one SNP in the 14q11.2 locus that was significantly associated with the Japanese food score with P values <5 × 10. Functional annotation revealed that the expression levels of two genes (BCL2L2, SLC22A17) were significantly inversely associated with this SNP. These genes are known to be related to olfaction and obesity. We found a new SNP that was associated with the Japanese food score in a Japanese population. This SNP is inversely associated with genes link to olfaction and obesity.","ja":"Individual eating habits may be influenced by genetic factors, in addition to environmental factors. Previous studies suggested that adherence to Japanese food patterns was associated with a decreased risk of all-cause and cardiovascular disease mortality. We conducted a genome-wide association study (GWAS) in a Japanese population to find genetic variations that affect adherence to a Japanese food pattern. We analyzed GWAS data using 14,079 participants from the Japan Multi-Institutional Collaborative Cohort study. We made a Japanese food score based on six food groups. Association of the imputed variants with the Japanese food score was performed by linear regression analysis with adjustments for age, sex, total energy intake, alcohol intake (g/day), and principal components 1-10 omitting variants in the major histocompatibility region. We found one SNP in the 14q11.2 locus that was significantly associated with the Japanese food score with P values <5 × 10. Functional annotation revealed that the expression levels of two genes (BCL2L2, SLC22A17) were significantly inversely associated with this SNP. These genes are known to be related to olfaction and obesity. We found a new SNP that was associated with the Japanese food score in a Japanese population. This SNP is inversely associated with genes link to olfaction and obesity."},"publication_date":"2020-12-06","publication_name":{"en":"European Journal of Clinical Nutrition","ja":"European Journal of Clinical Nutrition"},"languages":["eng"],"referee":true,"identifiers":{"doi":["10.1038/s41430-020-00823-z"],"issn":["1476-5640"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116254","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/33116160","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=373039","label":"url"}],"paper_title":{"en":"Association between plasma levels of homocysteine, folate, and vitamin B12, and dietary folate intake and hypertension in a cross-sectional study","ja":"Association between plasma levels of homocysteine, folate, and vitamin B12, and dietary folate intake and hypertension in a cross-sectional study"},"authors":{"en":[{"name":"Tamura Takashi"},{"name":"Kuriyama Nagato"},{"name":"Koyama Teruhide"},{"name":"Ozaki Etsuko"},{"name":"Matsui Daisuke"},{"name":"Kadomatsu Yuka"},{"name":"Tsukamoto Mineko"},{"name":"Kubo Yoko"},{"name":"Okada Rieko"},{"name":"Hishida Asahi"},{"name":"Sasakabe Tae"},{"name":"Kawai Sayo"},{"name":"Naito Mariko"},{"name":"Takashima Naoyuki"},{"name":"Kadota Aya"},{"name":"Tanaka Keitaro"},{"name":"Hara Megumi"},{"name":"Suzuki Sadao"},{"name":"Nakagawa-Senda Hiroko"},{"name":"Takezaki Toshiro"},{"name":"Shimoshikiryo Ippei"},{"name":"Ikezaki Hiroaki"},{"name":"Murata Masayuki"},{"name":"Oze Isao"},{"name":"Ito Hidemi"},{"name":"Mikami Haruo"},{"name":"Nakamura Yohko"},{"name":"Kuriki Kiyonori"},{"name":"Arisawa Kokichi"},{"name":"Uemura Hirokazu"},{"name":"Takeuchi Kenji"},{"name":"Wakai Kenji"}],"ja":[{"name":"Tamura Takashi"},{"name":"Kuriyama Nagato"},{"name":"Koyama Teruhide"},{"name":"Ozaki Etsuko"},{"name":"Matsui Daisuke"},{"name":"Kadomatsu Yuka"},{"name":"Tsukamoto Mineko"},{"name":"Kubo Yoko"},{"name":"Okada Rieko"},{"name":"Hishida Asahi"},{"name":"Sasakabe Tae"},{"name":"Kawai Sayo"},{"name":"Naito Mariko"},{"name":"Takashima Naoyuki"},{"name":"Kadota Aya"},{"name":"Tanaka Keitaro"},{"name":"Hara Megumi"},{"name":"Suzuki Sadao"},{"name":"Nakagawa-Senda Hiroko"},{"name":"Takezaki Toshiro"},{"name":"Shimoshikiryo Ippei"},{"name":"Ikezaki Hiroaki"},{"name":"Murata Masayuki"},{"name":"Oze Isao"},{"name":"Ito Hidemi"},{"name":"Mikami Haruo"},{"name":"Nakamura Yohko"},{"name":"Kuriki Kiyonori"},{"name":"有澤 孝吉"},{"name":"Uemura Hirokazu"},{"name":"Takeuchi Kenji"},{"name":"Wakai Kenji"}]},"description":{"en":"There are few studies examining the association between homocysteine (Hcy) level and the risk of hypertension with consideration for folate and vitamin B as related to Hcy level. We simultaneously examined the associations of plasma levels of Hcy, folate, and vitamin B, and dietary folate intake with the prevalence of hypertension. Participants included 1046 men and 1033 women (mean age ± standard deviation: 56.0 ± 8.9 years) in the Japan Multi-Institutional Collaborative Cohort Study. Dietary folate intake was estimated using a validated food frequency questionnaire. Hypertension was defined based on measured blood pressure and use of antihypertensive medication. A total of 734 participants (35.3%) had hypertension. Multivariate-adjusted odds ratios of hypertension for the highest quartile group of Hcy were 2.36 (95% CI 1.41-3.96) in men and 1.86 (95% CI 1.11-3.11) in women, as compared with the lowest group (P for trend = 0.014 and 0.005, respectively). Dietary folate intake was not correlated with hypertension in both men and women (P for trend = 0.099 and 0.703, respectively). Plasma vitamin B was positively associated with hypertension only in women (P for trend = 0.027). Plasma Hcy level was positively linked with hypertension after controlling for covariates, including folate and vitamin B.","ja":"There are few studies examining the association between homocysteine (Hcy) level and the risk of hypertension with consideration for folate and vitamin B as related to Hcy level. We simultaneously examined the associations of plasma levels of Hcy, folate, and vitamin B, and dietary folate intake with the prevalence of hypertension. Participants included 1046 men and 1033 women (mean age ± standard deviation: 56.0 ± 8.9 years) in the Japan Multi-Institutional Collaborative Cohort Study. Dietary folate intake was estimated using a validated food frequency questionnaire. Hypertension was defined based on measured blood pressure and use of antihypertensive medication. A total of 734 participants (35.3%) had hypertension. Multivariate-adjusted odds ratios of hypertension for the highest quartile group of Hcy were 2.36 (95% CI 1.41-3.96) in men and 1.86 (95% CI 1.11-3.11) in women, as compared with the lowest group (P for trend = 0.014 and 0.005, respectively). Dietary folate intake was not correlated with hypertension in both men and women (P for trend = 0.099 and 0.703, respectively). Plasma vitamin B was positively associated with hypertension only in women (P for trend = 0.027). Plasma Hcy level was positively linked with hypertension after controlling for covariates, including folate and vitamin B."},"publication_date":"2020-10-28","publication_name":{"en":"Scientific Reports","ja":"Scientific Reports"},"volume":"Vol.10","number":"No.1","starting_page":"18499","ending_page":"18499","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1038/s41598-020-75267-3"],"issn":["2045-2322"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=372215","label":"url"}],"paper_title":{"en":"Population-specific and transethnic genome-wide analyses reveal distinct and shared genetic risks of coronary artery disease","ja":"Population-specific and transethnic genome-wide analyses reveal distinct and shared genetic risks of coronary artery disease"},"authors":{"en":[{"name":"Satoshi Koyama"},{"name":"Kaoru Ito"},{"name":"Chikashi Terao"},{"name":"Masato Akiyama"},{"name":"Momoko Horikoshi"},{"name":"Yukihide Momozawa"},{"name":"Hiroshi Matsunaga"},{"name":"Hirotaka Ieki"},{"name":"Kouichi Ozaki"},{"name":"Yoshihiro Onouchi"},{"name":"Atsushi Takahashi"},{"name":"Seitaro Nomura"},{"name":"Hiroyuki Morita"},{"name":"Hiroshi Akazawa"},{"name":"Changhoon Kim"},{"name":"Jeong-sun Seo"},{"name":"Koichiro Higasa"},{"name":"Motoki Iwasaki"},{"name":"Taiki Yamaji"},{"name":"Norie Sawada"},{"name":"Shoichiro Tsugane"},{"name":"Teruhide Koyama"},{"name":"Hiroaki Ikezaki"},{"name":"Naoyuki Takashima"},{"name":"Keitaro Tanaka"},{"name":"Arisawa Kokichi"},{"name":"Kiyonori Kuriki"},{"name":"Mariko Naito"},{"name":"Kenji Wakai"},{"name":"Shinichiro Suna"},{"name":"Yasuhiko Sakata"},{"name":"Hiroshi Sato"},{"name":"Masatsugu Hori"},{"name":"Yasushi Sakata"},{"name":"Koichi Matsuda"},{"name":"Yoshinori Murakami"},{"name":"Hiroyuki Aburatani"},{"name":"Michiaki Kubo"},{"name":"Fumihiko Matsuda"},{"name":"Yoichiro Kamatani"},{"name":"Issei Komuro"}],"ja":[{"name":"Satoshi Koyama"},{"name":"Kaoru Ito"},{"name":"Chikashi Terao"},{"name":"Masato Akiyama"},{"name":"Momoko Horikoshi"},{"name":"Yukihide Momozawa"},{"name":"Hiroshi Matsunaga"},{"name":"Hirotaka Ieki"},{"name":"Kouichi Ozaki"},{"name":"Yoshihiro Onouchi"},{"name":"Atsushi Takahashi"},{"name":"Seitaro Nomura"},{"name":"Hiroyuki Morita"},{"name":"Hiroshi Akazawa"},{"name":"Changhoon Kim"},{"name":"Jeong-sun Seo"},{"name":"Koichiro Higasa"},{"name":"Motoki Iwasaki"},{"name":"Taiki Yamaji"},{"name":"Norie Sawada"},{"name":"Shoichiro Tsugane"},{"name":"Teruhide Koyama"},{"name":"Hiroaki Ikezaki"},{"name":"Naoyuki Takashima"},{"name":"Keitaro Tanaka"},{"name":"有澤 孝吉"},{"name":"Kiyonori Kuriki"},{"name":"Mariko Naito"},{"name":"Kenji Wakai"},{"name":"Shinichiro Suna"},{"name":"Yasuhiko Sakata"},{"name":"Hiroshi Sato"},{"name":"Masatsugu Hori"},{"name":"Yasushi Sakata"},{"name":"Koichi Matsuda"},{"name":"Yoshinori Murakami"},{"name":"Hiroyuki Aburatani"},{"name":"Michiaki Kubo"},{"name":"Fumihiko Matsuda"},{"name":"Yoichiro Kamatani"},{"name":"Issei Komuro"}]},"publication_date":"2020-10-05","publication_name":{"en":"Nature Genetics","ja":"Nature Genetics"},"languages":["eng"],"referee":true,"identifiers":{"doi":["10.1038/s41588-020-0705-3"],"issn":["1546-1718"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/32991979","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85094214635&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=372432","label":"url"}],"paper_title":{"en":"Association between alcohol intake pattern and metabolic syndrome components and simulated change by alcohol intake reduction: A cross-sectional study from the Japan Multi-Institutional Collaborative Cohort Study","ja":"Association between alcohol intake pattern and metabolic syndrome components and simulated change by alcohol intake reduction: A cross-sectional study from the Japan Multi-Institutional Collaborative Cohort Study"},"authors":{"en":[{"name":"Shimoshikiryo I"},{"name":"Ibusuki R"},{"name":"Shimatani K"},{"name":"Nishimoto D"},{"name":"Takezaki T"},{"name":"Nishida Y"},{"name":"Shimanoe C"},{"name":"Hishida A"},{"name":"Tamura T"},{"name":"Okada R"},{"name":"Kubo Y"},{"name":"Ozaki E"},{"name":"Matsui D"},{"name":"Suzuki S"},{"name":"Nakagawa-Senda H"},{"name":"Kuriki K"},{"name":"Kita Y"},{"name":"Takashima N"},{"name":"Arisawa Kokichi"},{"name":"Uemura H"},{"name":"Ikezaki H"},{"name":"Furusyo N"},{"name":"Oze I"},{"name":"Koyanagi YN"},{"name":"Mikami H"},{"name":"Nakamura Y"},{"name":"Naito M"},{"name":"Wakai K"}],"ja":[{"name":"Shimoshikiryo I"},{"name":"Ibusuki R"},{"name":"Shimatani K"},{"name":"Nishimoto D"},{"name":"Takezaki T"},{"name":"Nishida Y"},{"name":"Shimanoe C"},{"name":"Hishida A"},{"name":"Tamura T"},{"name":"Okada R"},{"name":"Kubo Y"},{"name":"Ozaki E"},{"name":"Matsui D"},{"name":"Suzuki S"},{"name":"Nakagawa-Senda H"},{"name":"Kuriki K"},{"name":"Kita Y"},{"name":"Takashima N"},{"name":"有澤 孝吉"},{"name":"Uemura H"},{"name":"Ikezaki H"},{"name":"Furusyo N"},{"name":"Oze I"},{"name":"Koyanagi YN"},{"name":"Mikami H"},{"name":"Nakamura Y"},{"name":"Naito M"},{"name":"Wakai K"}]},"publication_date":"2020-09-26","publication_name":{"en":"Alcohol","ja":"Alcohol"},"volume":"Vol.S0741-8329","number":"No.20","starting_page":"30284","ending_page":"6","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.alcohol.2020.09.002"],"issn":["0741-8329"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/32963210","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1390285697597241344/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=372212","label":"url"}],"paper_title":{"en":"Study profile of the Japan Multi-institutional Collaborative Cohort (J-MICC) Study","ja":"Study profile of the Japan Multi-institutional Collaborative Cohort (J-MICC) Study"},"authors":{"en":[{"name":"Takeuchi Kenji"},{"name":"Naito Mariko"},{"name":"Kawai Sayo"},{"name":"Tsukamoto Mineko"},{"name":"Kadomatsu Yuka"},{"name":"Kubo Yoko"},{"name":"Okada Rieko"},{"name":"Nagayoshi Mako"},{"name":"Tamura Takashi"},{"name":"Hishida Asahi"},{"name":"Nakatochi Masahiro"},{"name":"Sasakabe Tae"},{"name":"Hashimoto Shuji"},{"name":"Eguchi Hidetaka"},{"name":"Momozawa Yukihide"},{"name":"Ikezaki Hiroaki"},{"name":"Murata Masayuki"},{"name":"Furusyo Norihiro"},{"name":"Tanaka Keitaro"},{"name":"Hara Megumi"},{"name":"Nishida Yuichiro"},{"name":"Matsuo Keitaro"},{"name":"Ito Hidemi"},{"name":"Oze Isao"},{"name":"Mikami Haruo"},{"name":"Nakamura Yohko"},{"name":"Kusakabe Miho"},{"name":"Takezaki Toshiro"},{"name":"Ibusuki Rie"},{"name":"Shimoshikiryo Ippei"},{"name":"Suzuki Sadao"},{"name":"Nishiyama Takeshi"},{"name":"Watanabe Miki"},{"name":"Koyama Teruhide"},{"name":"Ozaki Etsuko"},{"name":"Watanabe Isao"},{"name":"Kuriki Kiyonori"},{"name":"Kita Yoshikuni"},{"name":"Ueshima Hirotsugu"},{"name":"Matsui Kenji"},{"name":"Arisawa Kokichi"},{"name":"Uemura Hirokazu"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Nakamura Sho"},{"name":"Narimatsu Hiroto"},{"name":"Hamajima Nobuyuki"},{"name":"Tanaka Hideo"},{"name":"Wakai Kenji"}],"ja":[{"name":"Takeuchi Kenji"},{"name":"Naito Mariko"},{"name":"Kawai Sayo"},{"name":"Tsukamoto Mineko"},{"name":"Kadomatsu Yuka"},{"name":"Kubo Yoko"},{"name":"Okada Rieko"},{"name":"Nagayoshi Mako"},{"name":"Tamura Takashi"},{"name":"Hishida Asahi"},{"name":"Nakatochi Masahiro"},{"name":"Sasakabe Tae"},{"name":"Hashimoto Shuji"},{"name":"Eguchi Hidetaka"},{"name":"Momozawa Yukihide"},{"name":"Ikezaki Hiroaki"},{"name":"Murata Masayuki"},{"name":"Furusyo Norihiro"},{"name":"Tanaka Keitaro"},{"name":"Hara Megumi"},{"name":"Nishida Yuichiro"},{"name":"Matsuo Keitaro"},{"name":"Ito Hidemi"},{"name":"Oze Isao"},{"name":"Mikami Haruo"},{"name":"Nakamura Yohko"},{"name":"Kusakabe Miho"},{"name":"Takezaki Toshiro"},{"name":"Ibusuki Rie"},{"name":"Shimoshikiryo Ippei"},{"name":"Suzuki Sadao"},{"name":"Nishiyama Takeshi"},{"name":"Watanabe Miki"},{"name":"Koyama Teruhide"},{"name":"Ozaki Etsuko"},{"name":"Watanabe Isao"},{"name":"Kuriki Kiyonori"},{"name":"Kita Yoshikuni"},{"name":"Ueshima Hirotsugu"},{"name":"Matsui Kenji"},{"name":"有澤 孝吉"},{"name":"上村 浩一"},{"name":"勝浦-釜野 桜子"},{"name":"Nakamura Sho"},{"name":"Narimatsu Hiroto"},{"name":"Hamajima Nobuyuki"},{"name":"Tanaka Hideo"},{"name":"Wakai Kenji"}]},"description":{"en":"The Japan Multi-institutional Collaborative Cohort (J-MICC) study was launched in 2005 to examine gene-environment interactions in lifestyle-related diseases, including cancers, among the Japanese. This report describes the study design and baseline profile of the study participants. The participants of the J-MICC Study were individuals aged 35 to 69 years enrolled from respondents to study announcements in specified regions, inhabitants attending health checkup examinations provided by local governments, visitors at health checkup centers, and first-visit patients at a cancer hospital in Japan. At the time of the baseline survey, from 2005 to 2014, we obtained comprehensive information regarding demographics, education, alcohol consumption, smoking, sleeping, exercise, food intake frequency, medication and supplement use, personal and family disease history, psychological stress, and female reproductive history, and collected peripheral blood samples. The baseline survey included 92,610 adults (mean age: 55.2 [9.4] years, 44.1% men) from 14 study regions in 12 prefectures. The participation rate was 33.5%, with participation ranging from 19.7% to 69.8% in different study regions. The largest number of participants was in the age groups of 65-69 years for men and 60-64 years for women. There were differences in body mass index, educational attainment, alcohol consumption, smoking, and sleep duration between men and women. The J-MICC Study collected lifestyle and clinical data and biospecimens from over 90,000 participants. This cohort is expected to be a valuable resource for the national and international scientific community in providing evidence to support longer healthy lives.","ja":"The Japan Multi-institutional Collaborative Cohort (J-MICC) study was launched in 2005 to examine gene-environment interactions in lifestyle-related diseases, including cancers, among the Japanese. This report describes the study design and baseline profile of the study participants. The participants of the J-MICC Study were individuals aged 35 to 69 years enrolled from respondents to study announcements in specified regions, inhabitants attending health checkup examinations provided by local governments, visitors at health checkup centers, and first-visit patients at a cancer hospital in Japan. At the time of the baseline survey, from 2005 to 2014, we obtained comprehensive information regarding demographics, education, alcohol consumption, smoking, sleeping, exercise, food intake frequency, medication and supplement use, personal and family disease history, psychological stress, and female reproductive history, and collected peripheral blood samples. The baseline survey included 92,610 adults (mean age: 55.2 [9.4] years, 44.1% men) from 14 study regions in 12 prefectures. The participation rate was 33.5%, with participation ranging from 19.7% to 69.8% in different study regions. The largest number of participants was in the age groups of 65-69 years for men and 60-64 years for women. There were differences in body mass index, educational attainment, alcohol consumption, smoking, and sleep duration between men and women. The J-MICC Study collected lifestyle and clinical data and biospecimens from over 90,000 participants. This cohort is expected to be a valuable resource for the national and international scientific community in providing evidence to support longer healthy lives."},"publication_date":"2020-09-19","publication_name":{"en":"Journal of Epidemiology","ja":"Journal of Epidemiology"},"volume":"Vol.31","number":"No.12","starting_page":"660","ending_page":"668","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2188/jea.JE20200147"],"issn":["1349-9092"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=372211","label":"url"}],"paper_title":{"en":"A genome-wide association study on fish consumption in a Japanese population-the Japan Multi-Institutional Collaborative Cohort study","ja":"A genome-wide association study on fish consumption in a Japanese population-the Japan Multi-Institutional Collaborative Cohort study"},"authors":{"en":[{"name":"Suzuki Taro"},{"name":"Nakamura Yasuyuki"},{"name":"Matsuo Keitaro"},{"name":"Oze Isao"},{"name":"Doi Yukio"},{"name":"Narita Akira"},{"name":"Shimizu Atsushi"},{"name":"Imaeda Nahomi"},{"name":"Goto Chiho"},{"name":"Matsui Kenji"},{"name":"Nakatochi Masahiro"},{"name":"Miura Katsuyuki"},{"name":"Takashima Naoyuki"},{"name":"Kuriki Kiyonori"},{"name":"Shimanoe Chisato"},{"name":"Tanaka Keitaro"},{"name":"Ikezaki Hiroaki"},{"name":"Murata Masayuki"},{"name":"Ibusuki Rie"},{"name":"Takezaki Toshiro"},{"name":"Koyanagi Yuriko"},{"name":"Ito Hidemi"},{"name":"Matsui Daisuke"},{"name":"Koyama Teruhide"},{"name":"Mikami Haruo"},{"name":"Nakamura Yohko"},{"name":"Suzuki Sadao"},{"name":"Nishiyama Takeshi"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Arisawa Kokichi"},{"name":"Takeuchi Kenji"},{"name":"Tamura Takashi"},{"name":"Okada Rieko"},{"name":"Kubo Yoko"},{"name":"Momozawa Yukihide"},{"name":"Kubo Michiaki"},{"name":"Kita Yoshikuni"},{"name":"Wakai Kenji"}],"ja":[{"name":"Suzuki Taro"},{"name":"Nakamura Yasuyuki"},{"name":"Matsuo Keitaro"},{"name":"Oze Isao"},{"name":"Doi Yukio"},{"name":"Narita Akira"},{"name":"Shimizu Atsushi"},{"name":"Imaeda Nahomi"},{"name":"Goto Chiho"},{"name":"Matsui Kenji"},{"name":"Nakatochi Masahiro"},{"name":"Miura Katsuyuki"},{"name":"Takashima Naoyuki"},{"name":"Kuriki Kiyonori"},{"name":"Shimanoe Chisato"},{"name":"Tanaka Keitaro"},{"name":"Ikezaki Hiroaki"},{"name":"Murata Masayuki"},{"name":"Ibusuki Rie"},{"name":"Takezaki Toshiro"},{"name":"Koyanagi Yuriko"},{"name":"Ito Hidemi"},{"name":"Matsui Daisuke"},{"name":"Koyama Teruhide"},{"name":"Mikami Haruo"},{"name":"Nakamura Yohko"},{"name":"Suzuki Sadao"},{"name":"Nishiyama Takeshi"},{"name":"勝浦-釜野 桜子"},{"name":"有澤 孝吉"},{"name":"Takeuchi Kenji"},{"name":"Tamura Takashi"},{"name":"Okada Rieko"},{"name":"Kubo Yoko"},{"name":"Momozawa Yukihide"},{"name":"Kubo Michiaki"},{"name":"Kita Yoshikuni"},{"name":"Wakai Kenji"}]},"publication_date":"2020-09-07","publication_name":{"en":"European Journal of Clinical Nutrition","ja":"European Journal of Clinical Nutrition"},"languages":["eng"],"referee":true,"identifiers":{"doi":["10.1038/s41430-020-00702-7"],"issn":["1476-5640"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/32469254","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=394057","label":"url"}],"paper_title":{"en":"Transethnic Meta-Analysis of Genome-Wide Association Studies Identifies Three New Loci and Characterizes Population-Specific Differences for Coronary Artery Disease","ja":"Transethnic Meta-Analysis of Genome-Wide Association Studies Identifies Three New Loci and Characterizes Population-Specific Differences for Coronary Artery Disease"},"authors":{"en":[{"name":"Matsunaga Hiroshi"},{"name":"Ito Kaoru"},{"name":"Akiyama Masato"},{"name":"Takahashi Atsushi"},{"name":"Koyama Satoshi"},{"name":"Nomura Seitaro"},{"name":"Ieki Hirotaka"},{"name":"Ozaki Kouichi"},{"name":"Onouchi Yoshihiro"},{"name":"Sakaue Saori"},{"name":"Suna Shinichiro"},{"name":"Ogishima Soichi"},{"name":"Yamamoto Masayuki"},{"name":"Hozawa Atsushi"},{"name":"Satoh Mamoru"},{"name":"Sasaki Makoto"},{"name":"Yamaji Taiki"},{"name":"Sawada Norie"},{"name":"Iwasaki Motoki"},{"name":"Tsugane Shoichiro"},{"name":"Tanaka Keitaro"},{"name":"Arisawa Kokichi"},{"name":"Ikezaki Hiroaki"},{"name":"Takashima Naoyuki"},{"name":"Naito Mariko"},{"name":"Wakai Kenji"},{"name":"Tanaka Hideo"},{"name":"Sakata Yasuhiko"},{"name":"Morita Hiroyuki"},{"name":"Sakata Yasushi"},{"name":"Matsuda Koichi"},{"name":"Murakami Yoshinori"},{"name":"Akazawa Hiroshi"},{"name":"Kubo Michiaki"},{"name":"Kamatani Yoichiro"},{"name":"Komuro Issei"}],"ja":[{"name":"Matsunaga Hiroshi"},{"name":"Ito Kaoru"},{"name":"Akiyama Masato"},{"name":"Takahashi Atsushi"},{"name":"Koyama Satoshi"},{"name":"Nomura Seitaro"},{"name":"Ieki Hirotaka"},{"name":"Ozaki Kouichi"},{"name":"Onouchi Yoshihiro"},{"name":"Sakaue Saori"},{"name":"Suna Shinichiro"},{"name":"Ogishima Soichi"},{"name":"Yamamoto Masayuki"},{"name":"Hozawa Atsushi"},{"name":"Satoh Mamoru"},{"name":"Sasaki Makoto"},{"name":"Yamaji Taiki"},{"name":"Sawada Norie"},{"name":"Iwasaki Motoki"},{"name":"Tsugane Shoichiro"},{"name":"Tanaka Keitaro"},{"name":"有澤 孝吉"},{"name":"Ikezaki Hiroaki"},{"name":"Takashima Naoyuki"},{"name":"Naito Mariko"},{"name":"Wakai Kenji"},{"name":"Tanaka Hideo"},{"name":"Sakata Yasuhiko"},{"name":"Morita Hiroyuki"},{"name":"Sakata Yasushi"},{"name":"Matsuda Koichi"},{"name":"Murakami Yoshinori"},{"name":"Akazawa Hiroshi"},{"name":"Kubo Michiaki"},{"name":"Kamatani Yoichiro"},{"name":"Komuro Issei"}]},"description":{"en":"Genome-wide association studies provided many biological insights into coronary artery disease (CAD), but these studies were mainly performed in Europeans. Genome-wide association studies in diverse populations have the potential to advance our understanding of CAD. We conducted 2 genome-wide association studies for CAD in the Japanese population, which included 12 494 cases and 28 879 controls and 2808 cases and 7261 controls, respectively. Then, we performed transethnic meta-analysis using the results of the coronary artery disease genome-wide replication and meta-analysis plus the coronary artery disease 1000 Genomes meta-analysis with UK Biobank. We then explored the pathophysiological significance of these novel loci and examined the differences in CAD-susceptibility loci between Japanese and Europeans. We identified 3 new loci on chromosome 1q21 (), 10q26 (), and 11q22 (-). Quantitative trait locus analyses suggested the association of and - with atherosclerotic immune cells. Tissue/cell type enrichment analysis showed the involvement of arteries, adrenal glands, and fat tissues in the development of CAD. We next compared the odds ratios of lead variants for myocardial infarction at 76 genome-wide significant loci in the transethnic meta-analysis and a moderate correlation between Japanese and Europeans, where 8 loci showed a difference. Finally, we performed tissue/cell type enrichment analysis using East Asian-frequent and European-frequent variants according to the risk allele frequencies and identified significant enrichment of adrenal glands in the East Asian-frequent group while the enrichment of arteries and fat tissues was found in the European-frequent group. These findings indicate biological differences in CAD susceptibility between Japanese and Europeans. We identified 3 new loci for CAD and highlighted the genetic differences between the Japanese and European populations. Moreover, our transethnic analyses showed both shared and unique genetic architectures between the Japanese and Europeans. While most of the underlying genetic bases for CAD are shared, further analyses in diverse populations will be needed to elucidate variations fully.","ja":"Genome-wide association studies provided many biological insights into coronary artery disease (CAD), but these studies were mainly performed in Europeans. Genome-wide association studies in diverse populations have the potential to advance our understanding of CAD. We conducted 2 genome-wide association studies for CAD in the Japanese population, which included 12 494 cases and 28 879 controls and 2808 cases and 7261 controls, respectively. Then, we performed transethnic meta-analysis using the results of the coronary artery disease genome-wide replication and meta-analysis plus the coronary artery disease 1000 Genomes meta-analysis with UK Biobank. We then explored the pathophysiological significance of these novel loci and examined the differences in CAD-susceptibility loci between Japanese and Europeans. We identified 3 new loci on chromosome 1q21 (), 10q26 (), and 11q22 (-). Quantitative trait locus analyses suggested the association of and - with atherosclerotic immune cells. Tissue/cell type enrichment analysis showed the involvement of arteries, adrenal glands, and fat tissues in the development of CAD. We next compared the odds ratios of lead variants for myocardial infarction at 76 genome-wide significant loci in the transethnic meta-analysis and a moderate correlation between Japanese and Europeans, where 8 loci showed a difference. Finally, we performed tissue/cell type enrichment analysis using East Asian-frequent and European-frequent variants according to the risk allele frequencies and identified significant enrichment of adrenal glands in the East Asian-frequent group while the enrichment of arteries and fat tissues was found in the European-frequent group. These findings indicate biological differences in CAD susceptibility between Japanese and Europeans. We identified 3 new loci for CAD and highlighted the genetic differences between the Japanese and European populations. Moreover, our transethnic analyses showed both shared and unique genetic architectures between the Japanese and Europeans. While most of the underlying genetic bases for CAD are shared, further analyses in diverse populations will be needed to elucidate variations fully."},"publication_date":"2020-06","publication_name":{"en":"Circulation. Genomic and Precision Medicine","ja":"Circulation. Genomic and Precision Medicine"},"volume":"Vol.13","number":"No.3","starting_page":"e002670","ending_page":"e002670","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1161/CIRCGEN.119.002670"],"issn":["2574-8300"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116245","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/32486113","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=366173","label":"url"}],"paper_title":{"en":"Association of dietary acid load with the prevalence of metabolic syndrome among participants in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study","ja":"Association of dietary acid load with the prevalence of metabolic syndrome among participants in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study"},"authors":{"en":[{"name":"Arisawa Kokichi"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Uemura Hirokazu"},{"name":"Tien Van Nguyen"},{"name":"Hishida Asahi"},{"name":"Tamura Takashi"},{"name":"Kubo Yoko"},{"name":"Tsukamoto Mineko"},{"name":"Tanaka Keitaro"},{"name":"Hara Megumi"},{"name":"Takezaki Toshiro"},{"name":"Nishimoto Daisaku"},{"name":"Koyama Teruhide"},{"name":"Ozaki Etsuko"},{"name":"Suzuki Sadao"},{"name":"Nishiyama Takeshi"},{"name":"Kuriki Kiyonori"},{"name":"Kadota Aya"},{"name":"Takashima Naoyuki"},{"name":"Ikezaki Hiroaki"},{"name":"Murata Masayuki"},{"name":"Oze Isao"},{"name":"Matsuo Keitaro"},{"name":"Mikami Haruo"},{"name":"Nakamura Yohko"},{"name":"Takeuchi Kenji"},{"name":"Wakai Kenji"}],"ja":[{"name":"有澤 孝吉"},{"name":"勝浦-釜野 桜子"},{"name":"上村 浩一"},{"name":"Tien Van Nguyen"},{"name":"Hishida Asahi"},{"name":"Tamura Takashi"},{"name":"Kubo Yoko"},{"name":"Tsukamoto Mineko"},{"name":"Tanaka Keitaro"},{"name":"Hara Megumi"},{"name":"Takezaki Toshiro"},{"name":"Nishimoto Daisaku"},{"name":"Koyama Teruhide"},{"name":"Ozaki Etsuko"},{"name":"Suzuki Sadao"},{"name":"Nishiyama Takeshi"},{"name":"Kuriki Kiyonori"},{"name":"Kadota Aya"},{"name":"Takashima Naoyuki"},{"name":"Ikezaki Hiroaki"},{"name":"Murata Masayuki"},{"name":"Oze Isao"},{"name":"Matsuo Keitaro"},{"name":"Mikami Haruo"},{"name":"Nakamura Yohko"},{"name":"Takeuchi Kenji"},{"name":"Wakai Kenji"}]},"description":{"en":"The association between dietary acid load and metabolic syndrome (MetS) has not been fully investigated. A cross-sectional study was performed on 14,042 men and 14,105 women (aged 35-69 years) who participated in a baseline survey of the Japan Multi-Institutional Collaborative Cohort study. Dietary acid load was assessed using the net-endogenous-acid-production (NEAP) score that is closely correlated with the rate of renal net acid excretion. MetS was diagnosed according to the Joint Interim Statement Criteria of 2009 using body-mass index instead of waist circumference. After adjusting for potential confounders, higher NEAP scores were associated with a significantly increased odds ratio (OR) of MetS, obesity, high blood pressure, and high fasting blood glucose. These associations remained significant after further adjustment for carbohydrate intake or two nutrient-pattern scores significantly associated with MetS. After adjustment for fiber, iron, potassium, and vitamin pattern scores, the OR of MetS for the highest quartile of NEAP scores, relative to the lowest quartile, was 1.25 (95% confidence interval 1.12-1.39). There was no significant interaction between sex, age, or body-mass index and NEAP. Higher dietary acid load was associated with a higher prevalence of MetS and several of its components, independently of carbohydrate intake or nutrient patterns.","ja":"The association between dietary acid load and metabolic syndrome (MetS) has not been fully investigated. A cross-sectional study was performed on 14,042 men and 14,105 women (aged 35-69 years) who participated in a baseline survey of the Japan Multi-Institutional Collaborative Cohort study. Dietary acid load was assessed using the net-endogenous-acid-production (NEAP) score that is closely correlated with the rate of renal net acid excretion. MetS was diagnosed according to the Joint Interim Statement Criteria of 2009 using body-mass index instead of waist circumference. After adjusting for potential confounders, higher NEAP scores were associated with a significantly increased odds ratio (OR) of MetS, obesity, high blood pressure, and high fasting blood glucose. These associations remained significant after further adjustment for carbohydrate intake or two nutrient-pattern scores significantly associated with MetS. After adjustment for fiber, iron, potassium, and vitamin pattern scores, the OR of MetS for the highest quartile of NEAP scores, relative to the lowest quartile, was 1.25 (95% confidence interval 1.12-1.39). There was no significant interaction between sex, age, or body-mass index and NEAP. Higher dietary acid load was associated with a higher prevalence of MetS and several of its components, independently of carbohydrate intake or nutrient patterns."},"publication_date":"2020-05","publication_name":{"en":"Nutrients","ja":"Nutrients"},"volume":"Vol.12","number":"No.6","starting_page":"1605","ending_page":"1605","languages":["eng"],"referee":true,"identifiers":{"doi":["10.3390/nu12061605"],"issn":["2072-6643"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/31481698","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85071937967&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=363568","label":"url"}],"paper_title":{"en":"Combined effect of weight gain within normal weight range and parental hypertension on the prevalence of hypertension; from the J-MICC Study.","ja":"Combined effect of weight gain within normal weight range and parental hypertension on the prevalence of hypertension; from the J-MICC Study."},"authors":{"en":[{"name":"Okada Rieko"},{"name":"Kadomatsu Yuka"},{"name":"Tsukamoto Mineko"},{"name":"Sasakabe Tae"},{"name":"Kawai Sayo"},{"name":"Tamura Takashi"},{"name":"Hishida Asahi"},{"name":"Ikezaki Hiroaki"},{"name":"Furusyo Norihiro"},{"name":"Tanaka Keitaro"},{"name":"Hara Megumi"},{"name":"Suzuki Sadao"},{"name":"Watanabe Miki"},{"name":"Takezaki Toshiro"},{"name":"Nishimoto Daisaku"},{"name":"Matsui Daisuke"},{"name":"Watanabe Isao"},{"name":"Kuriki Kiyonori"},{"name":"Takashima Naoyuki"},{"name":"Nakamura Yasuyuki"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Arisawa Kokichi"},{"name":"Mikami Haruo"},{"name":"Nakamura Yoko"},{"name":"Oze Isao"},{"name":"Koyanagi N. Yuriko"},{"name":"Naito Mariko"},{"name":"Wakai Kenji"},{"name":"Japan Multi-Institutional Collaborative Cohort (J-MICC) Study"}],"ja":[{"name":"Okada Rieko"},{"name":"Kadomatsu Yuka"},{"name":"Tsukamoto Mineko"},{"name":"Sasakabe Tae"},{"name":"Kawai Sayo"},{"name":"Tamura Takashi"},{"name":"Hishida Asahi"},{"name":"Ikezaki Hiroaki"},{"name":"Furusyo Norihiro"},{"name":"Tanaka Keitaro"},{"name":"Hara Megumi"},{"name":"Suzuki Sadao"},{"name":"Watanabe Miki"},{"name":"Takezaki Toshiro"},{"name":"Nishimoto Daisaku"},{"name":"Matsui Daisuke"},{"name":"Watanabe Isao"},{"name":"Kuriki Kiyonori"},{"name":"Takashima Naoyuki"},{"name":"Nakamura Yasuyuki"},{"name":"勝浦-釜野 桜子"},{"name":"有澤 孝吉"},{"name":"Mikami Haruo"},{"name":"Nakamura Yoko"},{"name":"Oze Isao"},{"name":"Koyanagi N. Yuriko"},{"name":"Naito Mariko"},{"name":"Wakai Kenji"},{"name":"Japan Multi-Institutional Collaborative Cohort (J-MICC) Study"}]},"description":{"en":"The aim of this study is to show the combined effect of weight gain within normal weight range in adulthood and parental HT on the prevalence of HT. The study subjects were 44,998 individuals (19,039 men and 25,959 women) with normal weight (body mass index [BMI] 18.5-24.9) aged 35-69 years who participated in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. They were categorized into six groups by weight gain from age 20 years (<10 kg, and ≥10 kg) and by the number of parents having HT (no parent, one parent, and both parents). Odds ratios for HT were estimated after adjustment for age, sex, current BMI, estimated daily sodium intake, and other confounding factors. The prevalence of HT (31.5% in total subjects) gradually increased with greater weight gain from age 20 years and with greater number of parents with HT. Subjects who gained weight ≥10 kg and having both parents with HT showed the highest risk of having HT compared with those who gained weight <10 kg without parental HT (59.8% vs. 24.9%, odds ratio 4.25, 95% CI 3.53-5.13 after adjustment). This association was similarly observed in any category of age, sex, and BMI. Subjects who gained weight within normal range of BMI and having one or both parent(s) with HT showed the higher risk of having HT independent of their attained BMI in their middle ages. Thus, subjects having parent(s) with HT should avoid gaining their weight during adulthood, even within normal range of BMI, to reduce the risk of having HT.","ja":"The aim of this study is to show the combined effect of weight gain within normal weight range in adulthood and parental HT on the prevalence of HT. The study subjects were 44,998 individuals (19,039 men and 25,959 women) with normal weight (body mass index [BMI] 18.5-24.9) aged 35-69 years who participated in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. They were categorized into six groups by weight gain from age 20 years (<10 kg, and ≥10 kg) and by the number of parents having HT (no parent, one parent, and both parents). Odds ratios for HT were estimated after adjustment for age, sex, current BMI, estimated daily sodium intake, and other confounding factors. The prevalence of HT (31.5% in total subjects) gradually increased with greater weight gain from age 20 years and with greater number of parents with HT. Subjects who gained weight ≥10 kg and having both parents with HT showed the highest risk of having HT compared with those who gained weight <10 kg without parental HT (59.8% vs. 24.9%, odds ratio 4.25, 95% CI 3.53-5.13 after adjustment). This association was similarly observed in any category of age, sex, and BMI. Subjects who gained weight within normal range of BMI and having one or both parent(s) with HT showed the higher risk of having HT independent of their attained BMI in their middle ages. Thus, subjects having parent(s) with HT should avoid gaining their weight during adulthood, even within normal range of BMI, to reduce the risk of having HT."},"publication_date":"2020-02","publication_name":{"en":"Journal of Human Hypertension","ja":"Journal of Human Hypertension"},"volume":"Vol.34","number":"No.2","starting_page":"125","ending_page":"131","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1038/s41371-019-0230-y"],"issn":["1476-5527"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/114939","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/31988393","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=363561","label":"url"}],"paper_title":{"en":"Identification of a novel uterine leiomyoma GWAS locus in a Japanese population.","ja":"Identification of a novel uterine leiomyoma GWAS locus in a Japanese population."},"authors":{"en":[{"name":"Sakai K"},{"name":"Tanikawa C"},{"name":"Hirasawa A"},{"name":"Chiyoda T"},{"name":"Yamagami W"},{"name":"Kataoka F"},{"name":"Susumu N"},{"name":"Terao C"},{"name":"Kamatani Y"},{"name":"Takahashi A"},{"name":"Momozawa Y"},{"name":"Hirata M"},{"name":"Kubo M"},{"name":"Fuse N"},{"name":"Takai-Igarashi T"},{"name":"Shimizu A"},{"name":"Fukushima A"},{"name":"Kadota A"},{"name":"Arisawa Kokichi"},{"name":"Ikezaki H"},{"name":"Wakai K"},{"name":"Yamaji T"},{"name":"Sawada N"},{"name":"Iwasaki M"},{"name":"Tsugane S"},{"name":"Aoki D"},{"name":"Matsuda K"}],"ja":[{"name":"Sakai K"},{"name":"Tanikawa C"},{"name":"Hirasawa A"},{"name":"Chiyoda T"},{"name":"Yamagami W"},{"name":"Kataoka F"},{"name":"Susumu N"},{"name":"Terao C"},{"name":"Kamatani Y"},{"name":"Takahashi A"},{"name":"Momozawa Y"},{"name":"Hirata M"},{"name":"Kubo M"},{"name":"Fuse N"},{"name":"Takai-Igarashi T"},{"name":"Shimizu A"},{"name":"Fukushima A"},{"name":"Kadota A"},{"name":"有澤 孝吉"},{"name":"Ikezaki H"},{"name":"Wakai K"},{"name":"Yamaji T"},{"name":"Sawada N"},{"name":"Iwasaki M"},{"name":"Tsugane S"},{"name":"Aoki D"},{"name":"Matsuda K"}]},"description":{"en":"Uterine leiomyoma is one of the most common gynaecologic benign tumours, but its genetic basis remains largely unknown. Six previous GWAS identified 33 genetic factors in total. Here, we performed a two-staged GWAS using 13,746 cases and 70,316 controls from the Japanese population, followed by a replication analysis using 3,483 cases and 4,795 controls. The analysis identified 9 significant loci, including a novel locus on 12q23.2 (rs17033114, P = 6.12 × 10 with an OR of 1.177 (1.141-1.213), LINC00485). Subgroup analysis indicated that 5 loci (3q26.2, 5p15.33, 10q24.33, 11p15.5, 13q14.11) exhibited a statistically significant effect among multiple leiomyomas, and 2 loci (3q26.2, 10q24.33) exhibited a significant effect among submucous leiomyomas. Pleiotropic analysis indicated that all 9 loci were associated with at least one proliferative disease, suggesting the role of these loci in the common neoplastic pathway. Furthermore, the risk T allele of rs2251795 (3q26.2) was associated with longer telomere length in both normal and tumour tissues. Our findings elucidated the significance of genetic factors in the pathogenesis of leiomyoma.","ja":"Uterine leiomyoma is one of the most common gynaecologic benign tumours, but its genetic basis remains largely unknown. Six previous GWAS identified 33 genetic factors in total. Here, we performed a two-staged GWAS using 13,746 cases and 70,316 controls from the Japanese population, followed by a replication analysis using 3,483 cases and 4,795 controls. The analysis identified 9 significant loci, including a novel locus on 12q23.2 (rs17033114, P = 6.12 × 10 with an OR of 1.177 (1.141-1.213), LINC00485). Subgroup analysis indicated that 5 loci (3q26.2, 5p15.33, 10q24.33, 11p15.5, 13q14.11) exhibited a statistically significant effect among multiple leiomyomas, and 2 loci (3q26.2, 10q24.33) exhibited a significant effect among submucous leiomyomas. Pleiotropic analysis indicated that all 9 loci were associated with at least one proliferative disease, suggesting the role of these loci in the common neoplastic pathway. Furthermore, the risk T allele of rs2251795 (3q26.2) was associated with longer telomere length in both normal and tumour tissues. Our findings elucidated the significance of genetic factors in the pathogenesis of leiomyoma."},"publication_date":"2020-01-27","publication_name":{"en":"Scientific Reports","ja":"Scientific Reports"},"volume":"Vol.10","number":"No.1","starting_page":"1197","ending_page":"1197","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1038/s41598-020-58066-8"],"issn":["2045-2322"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/30922534","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=363570","label":"url"}],"paper_title":{"en":"Correlation between playing position, elbow physical findings and elbow pain in elementary school baseball players: Results of a multi-regional study in Japan.","ja":"Correlation between playing position, elbow physical findings and elbow pain in elementary school baseball players: Results of a multi-regional study in Japan."},"authors":{"en":[{"name":"Matsuura Tetsuya"},{"name":"Chosa E"},{"name":"Tajika T"},{"name":"Masatomi T"},{"name":"Arimitsu S"},{"name":"Yamamoto A"},{"name":"Nagasawa M"},{"name":"Arisawa Kokichi"},{"name":"Takagishi K"}],"ja":[{"name":"松浦 哲也"},{"name":"Chosa E"},{"name":"Tajika T"},{"name":"Masatomi T"},{"name":"Arimitsu S"},{"name":"Yamamoto A"},{"name":"Nagasawa M"},{"name":"有澤 孝吉"},{"name":"Takagishi K"}]},"description":{"en":"Elbow injuries are common in young baseball players and evaluating the characteristics of young baseball players in a large-scale population is necessary. However, few studies have compared playing position, length of baseball experience, physical findings, and elbow pain in young baseball players. This retrospective multi-regional cohort study sought to document the physical findings at the elbow in Japanese elementary school baseball players and to examine the relationship between playing position, length of baseball experience, physical findings at the elbow, and elbow pain. In 2014, 720 fifth-grade baseball players from four regions in Japan were invited to participate in a questionnaire survey and undergo physical examination to obtain data on position played, length of baseball experience, presence of elbow pain, and physical findings at the elbow, including range of motion, tenderness, and valgus stress test results. Potential risk factors associated with elbow pain and correlations between physical findings and playing position, length of baseball experience, and elbow pain were investigated. The 720 subjects had a mean age of 10.4 years and 29.4% reported having experienced elbow pain for ≥1 week. Risk factors for elbow pain included playing pitcher and catcher, playing pitcher and fielder, and length of baseball experience. The most frequent finding was limitation of flexion (21.1%) followed by tenderness of the medial epicondyle (18.3%) and a positive valgus stress test (14.3%). These three findings were also significantly associated with elbow pain. Elbow extension was limited in 14.9% of subjects but there was no correlation with length of baseball experience or elbow pain. Our data show that elementary school baseball players who experienced elbow pain are likely to have valgus stress overload. Elbow pain might be prevented by not playing pitcher and catcher.","ja":"Elbow injuries are common in young baseball players and evaluating the characteristics of young baseball players in a large-scale population is necessary. However, few studies have compared playing position, length of baseball experience, physical findings, and elbow pain in young baseball players. This retrospective multi-regional cohort study sought to document the physical findings at the elbow in Japanese elementary school baseball players and to examine the relationship between playing position, length of baseball experience, physical findings at the elbow, and elbow pain. In 2014, 720 fifth-grade baseball players from four regions in Japan were invited to participate in a questionnaire survey and undergo physical examination to obtain data on position played, length of baseball experience, presence of elbow pain, and physical findings at the elbow, including range of motion, tenderness, and valgus stress test results. Potential risk factors associated with elbow pain and correlations between physical findings and playing position, length of baseball experience, and elbow pain were investigated. The 720 subjects had a mean age of 10.4 years and 29.4% reported having experienced elbow pain for ≥1 week. Risk factors for elbow pain included playing pitcher and catcher, playing pitcher and fielder, and length of baseball experience. The most frequent finding was limitation of flexion (21.1%) followed by tenderness of the medial epicondyle (18.3%) and a positive valgus stress test (14.3%). These three findings were also significantly associated with elbow pain. Elbow extension was limited in 14.9% of subjects but there was no correlation with length of baseball experience or elbow pain. Our data show that elementary school baseball players who experienced elbow pain are likely to have valgus stress overload. Elbow pain might be prevented by not playing pitcher and catcher."},"publication_date":"2020-01","publication_name":{"en":"Journal of Orthopaedic Science","ja":"Journal of Orthopaedic Science"},"volume":"Vol.25","number":"No.1","starting_page":"122","ending_page":"126","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.jos.2019.02.020"],"issn":["1436-2023"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/115573","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/31839644","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=363565","label":"url"}],"paper_title":{"en":"Impact of PSCA polymorphisms on the risk of duodenal ulcer.","ja":"Impact of PSCA polymorphisms on the risk of duodenal ulcer."},"authors":{"en":[{"name":"Usui Y"},{"name":"Matsuo K"},{"name":"Oze I"},{"name":"Ugai T"},{"name":"Koyanagi Y"},{"name":"Maeda Y"},{"name":"Ito H"},{"name":"Hishida A"},{"name":"Takeuchi K"},{"name":"Tamura T"},{"name":"Tsukamoto M"},{"name":"Kadomatsu Y"},{"name":"Hara M"},{"name":"Nishida Y"},{"name":"Shimoshikiryo I"},{"name":"Takezaki T"},{"name":"Ozaki E"},{"name":"Matsui D"},{"name":"Watanabe I"},{"name":"Suzuki S"},{"name":"Watanabe M"},{"name":"Nakagawa-Senda H"},{"name":"Mikami H"},{"name":"Nakamura Y"},{"name":"Arisawa Kokichi"},{"name":"Uemura Hirokazu"},{"name":"Kuriki K"},{"name":"Takashima N"},{"name":"Kadota A"},{"name":"Ikezaki H"},{"name":"Murata M"},{"name":"Nakatochi M"},{"name":"Momozawa Y"},{"name":"Kubo M"},{"name":"Wakai K"}],"ja":[{"name":"Usui Y"},{"name":"Matsuo K"},{"name":"Oze I"},{"name":"Ugai T"},{"name":"Koyanagi Y"},{"name":"Maeda Y"},{"name":"Ito H"},{"name":"Hishida A"},{"name":"Takeuchi K"},{"name":"Tamura T"},{"name":"Tsukamoto M"},{"name":"Kadomatsu Y"},{"name":"Hara M"},{"name":"Nishida Y"},{"name":"Shimoshikiryo I"},{"name":"Takezaki T"},{"name":"Ozaki E"},{"name":"Matsui D"},{"name":"Watanabe I"},{"name":"Suzuki S"},{"name":"Watanabe M"},{"name":"Nakagawa-Senda H"},{"name":"Mikami H"},{"name":"Nakamura Y"},{"name":"有澤 孝吉"},{"name":"上村 浩一"},{"name":"Kuriki K"},{"name":"Takashima N"},{"name":"Kadota A"},{"name":"Ikezaki H"},{"name":"Murata M"},{"name":"Nakatochi M"},{"name":"Momozawa Y"},{"name":"Kubo M"},{"name":"Wakai K"}]},"publication_date":"2019-12-14","publication_name":{"en":"Journal of Epidemiology","ja":"Journal of Epidemiology"},"starting_page":"JE20190184","ending_page":"JE20190184","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2188/jea.JE20190184"],"issn":["1349-9092"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/114985","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/31289104","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=361068","label":"url"}],"paper_title":{"en":"Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout.","ja":"Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout."},"authors":{"en":[{"name":"Kawamura Yusuke"},{"name":"Nakaoka Hirofumi"},{"name":"Nakayama Akiyoshi"},{"name":"Okada Yukinori"},{"name":"Yamamoto Ken"},{"name":"Higashino Toshihide"},{"name":"Sakiyama Masayuki"},{"name":"Shimizu Toru"},{"name":"Ooyama Hiroshi"},{"name":"Ooyama Keiko"},{"name":"Nagase Mitsuo"},{"name":"Hidaka Yuji"},{"name":"Shirahama Yuko"},{"name":"Hosomichi Kazuyoshi"},{"name":"Nishida Yuichiro"},{"name":"Shimoshikiryo Ippei"},{"name":"Hishida Asahi"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Shimizu Seiko"},{"name":"Kawaguchi Makoto"},{"name":"Uemura Hirokazu"},{"name":"Ibusuki Rie"},{"name":"Hara Megumi"},{"name":"Naito Mariko"},{"name":"Takao Mikiya"},{"name":"Nakajima Mayuko"},{"name":"Iwasawa Satoko"},{"name":"Nakashima Hiroshi"},{"name":"Ohnaka Keizo"},{"name":"Nakamura Takahiro"},{"name":"Stiburkova Blanka"},{"name":"Merriman R. Tony"},{"name":"Nakatochi Masahiro"},{"name":"Ichihara Sahoko"},{"name":"Yokota Mitsuhiro"},{"name":"Takada Tappei"},{"name":"Saitoh Tatsuya"},{"name":"Kamatani Yoichiro"},{"name":"Takahashi Atsushi"},{"name":"Arisawa Kokichi"},{"name":"Takezaki Toshiro"},{"name":"Tanaka Keitaro"},{"name":"Wakai Kenji"},{"name":"Kubo Michiaki"},{"name":"Hosoya Tatsuo"},{"name":"Ichida Kimiyoshi"},{"name":"Inoue Ituro"},{"name":"Shinomiya Nariyoshi"},{"name":"Matsuo Hirotaka"}],"ja":[{"name":"Kawamura Yusuke"},{"name":"Nakaoka Hirofumi"},{"name":"Nakayama Akiyoshi"},{"name":"Okada Yukinori"},{"name":"Yamamoto Ken"},{"name":"Higashino Toshihide"},{"name":"Sakiyama Masayuki"},{"name":"Shimizu Toru"},{"name":"Ooyama Hiroshi"},{"name":"Ooyama Keiko"},{"name":"Nagase Mitsuo"},{"name":"Hidaka Yuji"},{"name":"Shirahama Yuko"},{"name":"Hosomichi Kazuyoshi"},{"name":"Nishida Yuichiro"},{"name":"Shimoshikiryo Ippei"},{"name":"Hishida Asahi"},{"name":"勝浦-釜野 桜子"},{"name":"Shimizu Seiko"},{"name":"Kawaguchi Makoto"},{"name":"上村 浩一"},{"name":"Ibusuki Rie"},{"name":"Hara Megumi"},{"name":"Naito Mariko"},{"name":"Takao Mikiya"},{"name":"Nakajima Mayuko"},{"name":"Iwasawa Satoko"},{"name":"Nakashima Hiroshi"},{"name":"Ohnaka Keizo"},{"name":"Nakamura Takahiro"},{"name":"Stiburkova Blanka"},{"name":"Merriman R. Tony"},{"name":"Nakatochi Masahiro"},{"name":"Ichihara Sahoko"},{"name":"Yokota Mitsuhiro"},{"name":"Takada Tappei"},{"name":"Saitoh Tatsuya"},{"name":"Kamatani Yoichiro"},{"name":"Takahashi Atsushi"},{"name":"有澤 孝吉"},{"name":"Takezaki Toshiro"},{"name":"Tanaka Keitaro"},{"name":"Wakai Kenji"},{"name":"Kubo Michiaki"},{"name":"Hosoya Tatsuo"},{"name":"Ichida Kimiyoshi"},{"name":"Inoue Ituro"},{"name":"Shinomiya Nariyoshi"},{"name":"Matsuo Hirotaka"}]},"description":{"en":"The first ever genome-wide association study (GWAS) of clinically defined gout cases and asymptomatic hyperuricaemia (AHUA) controls was performed to identify novel gout loci that aggravate AHUA into gout. We carried out a GWAS of 945 clinically defined gout cases and 1003 AHUA controls followed by 2 replication studies. In total, 2860 gout cases and 3149 AHUA controls (all Japanese men) were analysed. We also compared the ORs for each locus in the present GWAS (gout vs AHUA) with those in the previous GWAS (gout vs normouricaemia). This new approach enabled us to identify two novel gout loci (rs7927466 of and rs9952962 of ) and one suggestive locus (rs12980365 of ) at the genome-wide significance level (p<5.0 10). The present study also identified the loci of , and . One of them, rs671 of , was identified as a gout locus by GWAS for the first time. Comparing ORs for each locus in the present versus the previous GWAS revealed three 'gout vs AHUA GWAS'-specific loci (, and ) to be clearly associated with mechanisms of gout development which distinctly differ from the known gout risk loci that basically elevate serum uric acid level. This meta-analysis is the first to reveal the loci associated with crystal-induced inflammation, the last step in gout development that aggravates AHUA into gout. Our findings should help to elucidate the molecular mechanisms of gout development and assist the prevention of gout attacks in high-risk AHUA individuals.","ja":"The first ever genome-wide association study (GWAS) of clinically defined gout cases and asymptomatic hyperuricaemia (AHUA) controls was performed to identify novel gout loci that aggravate AHUA into gout. We carried out a GWAS of 945 clinically defined gout cases and 1003 AHUA controls followed by 2 replication studies. In total, 2860 gout cases and 3149 AHUA controls (all Japanese men) were analysed. We also compared the ORs for each locus in the present GWAS (gout vs AHUA) with those in the previous GWAS (gout vs normouricaemia). This new approach enabled us to identify two novel gout loci (rs7927466 of and rs9952962 of ) and one suggestive locus (rs12980365 of ) at the genome-wide significance level (p<5.0 10). The present study also identified the loci of , and . One of them, rs671 of , was identified as a gout locus by GWAS for the first time. Comparing ORs for each locus in the present versus the previous GWAS revealed three 'gout vs AHUA GWAS'-specific loci (, and ) to be clearly associated with mechanisms of gout development which distinctly differ from the known gout risk loci that basically elevate serum uric acid level. This meta-analysis is the first to reveal the loci associated with crystal-induced inflammation, the last step in gout development that aggravates AHUA into gout. Our findings should help to elucidate the molecular mechanisms of gout development and assist the prevention of gout attacks in high-risk AHUA individuals."},"publication_date":"2019-07-08","publication_name":{"en":"Annals of the Rheumatic Diseases","ja":"Annals of the Rheumatic Diseases"},"volume":"Vol.78","number":"No.10","starting_page":"1430","ending_page":"1437","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1136/annrheumdis-2019-215521"],"issn":["1468-2060"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/30146708","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=352766","label":"url"}],"paper_title":{"en":"Association of genetic risk score and chronic kidney disease in a Japanese population","ja":"Association of genetic risk score and chronic kidney disease in a Japanese population"},"authors":{"en":[{"name":"Fujii R"},{"name":"Hishida A"},{"name":"Nakatochi M"},{"name":"Furusyo N"},{"name":"Murata M"},{"name":"Tanaka K"},{"name":"Shimanoe C"},{"name":"Suzuki S"},{"name":"Watanabe M"},{"name":"Kuriyama N"},{"name":"Koyama T"},{"name":"Takezaki T"},{"name":"Shimoshikiryo I"},{"name":"Arisawa Kokichi"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Takashima N"},{"name":"Turin TC,"},{"name":"Kuriki K"},{"name":"Endoh K"},{"name":"Mikami H"},{"name":"Nakamura Y"},{"name":"Oze I"},{"name":"Ito H"},{"name":"Kubo M"},{"name":"Momozawa Y"},{"name":"Kondo T"},{"name":"Naito M"},{"name":"Wakai K"}],"ja":[{"name":"Fujii R"},{"name":"Hishida A"},{"name":"Nakatochi M"},{"name":"Furusyo N"},{"name":"Murata M"},{"name":"Tanaka K"},{"name":"Shimanoe C"},{"name":"Suzuki S"},{"name":"Watanabe M"},{"name":"Kuriyama N"},{"name":"Koyama T"},{"name":"Takezaki T"},{"name":"Shimoshikiryo I"},{"name":"有澤 孝吉"},{"name":"勝浦-釜野 桜子"},{"name":"Takashima N"},{"name":"Turin TC,"},{"name":"Kuriki K"},{"name":"Endoh K"},{"name":"Mikami H"},{"name":"Nakamura Y"},{"name":"Oze I"},{"name":"Ito H"},{"name":"Kubo M"},{"name":"Momozawa Y"},{"name":"Kondo T"},{"name":"Naito M"},{"name":"Wakai K"}]},"description":{"en":"Chronic kidney disease (CKD) is a public health problem worldwide including Japan. Recent genome-wide association studies have discovered CKD susceptibility variants. We developed a genetic risk score (GRS) based on CKD-associated variants and assessed a possibility that the GRS can improve the discrimination capability for the prevalence of CKD in a Japanese population. The present study consists of 11 283 participants randomly selected from 12 Japan Multi-Institutional Collaborative Cohort Study sites. Individual GRS was constructed combining 18 single-nucleotide polymorphisms identified in a Japanese population. Participants with eGFR <60 mL/min per 1.73 m was defined as case (stage 3 CKD or higher) in this study. Logistic regression analysis was used to examine the association between the GRS and CKD risk with adjustment for sex, age, hypertension and type 2 diabetes mellitus. The frequency of individuals with CKD was 8.3%, which was relatively low compared with those previously reported in a Japanese population. The odds ratio of having CKD was 1.120 (95% confidence interval: 1.042-1.203) per 10 GRS increment in the fully adjusted model (P = 0.002). The C-statistic was significantly increased in the model with the GRS, comparing with the model without the GRS (0.720 vs 0.719, P = 0.008). Increment of the GRS was associated with increased risk of CKD. Additionally, the GRS significantly improved the discriminatory ability of CKD prevalence in a Japanese population; however, the improvement of discriminatory ability brought about by the GRS seemed to be small compared with that of non-genetic CKD risk factors.","ja":"Chronic kidney disease (CKD) is a public health problem worldwide including Japan. Recent genome-wide association studies have discovered CKD susceptibility variants. We developed a genetic risk score (GRS) based on CKD-associated variants and assessed a possibility that the GRS can improve the discrimination capability for the prevalence of CKD in a Japanese population. The present study consists of 11 283 participants randomly selected from 12 Japan Multi-Institutional Collaborative Cohort Study sites. Individual GRS was constructed combining 18 single-nucleotide polymorphisms identified in a Japanese population. Participants with eGFR <60 mL/min per 1.73 m was defined as case (stage 3 CKD or higher) in this study. Logistic regression analysis was used to examine the association between the GRS and CKD risk with adjustment for sex, age, hypertension and type 2 diabetes mellitus. The frequency of individuals with CKD was 8.3%, which was relatively low compared with those previously reported in a Japanese population. The odds ratio of having CKD was 1.120 (95% confidence interval: 1.042-1.203) per 10 GRS increment in the fully adjusted model (P = 0.002). The C-statistic was significantly increased in the model with the GRS, comparing with the model without the GRS (0.720 vs 0.719, P = 0.008). Increment of the GRS was associated with increased risk of CKD. Additionally, the GRS significantly improved the discriminatory ability of CKD prevalence in a Japanese population; however, the improvement of discriminatory ability brought about by the GRS seemed to be small compared with that of non-genetic CKD risk factors."},"publication_date":"2019-06","publication_name":{"en":"Nephrology","ja":"Nephrology"},"volume":"Vol.24","number":"No.6","starting_page":"670","ending_page":"673","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1111/nep.13479"],"issn":["1440-1797"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/114285","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/30859748","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85062790988&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=352744","label":"url"}],"paper_title":{"en":"Trajectories of class-switching-related egg and cow's milk allergen-specific immunoglobulin isotype formation and its modification by eczema with low- and high-affinity immunoglobulin E during early infancy","ja":"Trajectories of class-switching-related egg and cow's milk allergen-specific immunoglobulin isotype formation and its modification by eczema with low- and high-affinity immunoglobulin E during early infancy"},"authors":{"en":[{"name":"Irahara Makoto"},{"name":"Shinahara Wakako"},{"name":"Sugimoto Mayumi"},{"name":"Ogawa Yukiko"},{"name":"Shitsukawa Keiji"},{"name":"Kubota Kenji"},{"name":"Yang Limin"},{"name":"Ohya Yukihiro"},{"name":"Saito Hirohisa"},{"name":"Kagami Shoji"},{"name":"Arisawa Kokichi"},{"name":"Kido Hiroshi"}],"ja":[{"name":"苛原 誠"},{"name":"Shinahara Wakako"},{"name":"杉本 真弓"},{"name":"Ogawa Yukiko"},{"name":"Shitsukawa Keiji"},{"name":"Kubota Kenji"},{"name":"Yang Limin"},{"name":"Ohya Yukihiro"},{"name":"Saito Hirohisa"},{"name":"香美 祥二"},{"name":"有澤 孝吉"},{"name":"木戸 博"}]},"description":{"en":"Allergen-specific immunoglobulin isotype formation associated with immunoglobulin class-switching during the lactation period is the immunological background for food allergy in infants. We analyzed the serial changes in the production of feeding type-related egg- and milk-specific immunoglobulin isotypes from birth to 6 months of age with or without eczema in 84 infants. Allergen-specific immunoglobulin G1 (IgG1), IgG2, IgG3, IgG4, IgA, and IgE levels of hen's egg and bovine milk were measured in cord blood and blood samples from infants at 2, 4, and 6 months of age by the densely carboxylated protein microarray. Formula and mixed feeding were associated with a rapid increase in cow's milk allergen-specific immunoglobulins and feeding type-related significant differences in casein-specific immunoglobulin levels were detected. Breast and mixed feeding were associated with slow but significant increase in ovalbumin-specific IgG1 and IgE levels, but not other immunoglobulins. We found two different immunoglobulin isotype formation at 6 months of age with low- or high-affinity IgE against ovalbumin. One isotype formation pattern had relatively high ovalbumin-specific IgG1 levels, detectable IgG2, and low-affinity IgE, while the other had low ovalbumin-specific IgG1 levels, undetectable IgG2, and high levels of high-affinity IgE. The incidence of eczema was significantly higher in the latter pattern (84.6%), compared with the remaining infants (42.2%). Feeding practice-related allergen sensitization and immunoglobulin isotype formation were identified during the lactation period. The development of eczema during the lactation period could potentially modify the immunoglobulin isotype formation with high levels of high-affinity IgE.","ja":"Allergen-specific immunoglobulin isotype formation associated with immunoglobulin class-switching during the lactation period is the immunological background for food allergy in infants. We analyzed the serial changes in the production of feeding type-related egg- and milk-specific immunoglobulin isotypes from birth to 6 months of age with or without eczema in 84 infants. Allergen-specific immunoglobulin G1 (IgG1), IgG2, IgG3, IgG4, IgA, and IgE levels of hen's egg and bovine milk were measured in cord blood and blood samples from infants at 2, 4, and 6 months of age by the densely carboxylated protein microarray. Formula and mixed feeding were associated with a rapid increase in cow's milk allergen-specific immunoglobulins and feeding type-related significant differences in casein-specific immunoglobulin levels were detected. Breast and mixed feeding were associated with slow but significant increase in ovalbumin-specific IgG1 and IgE levels, but not other immunoglobulins. We found two different immunoglobulin isotype formation at 6 months of age with low- or high-affinity IgE against ovalbumin. One isotype formation pattern had relatively high ovalbumin-specific IgG1 levels, detectable IgG2, and low-affinity IgE, while the other had low ovalbumin-specific IgG1 levels, undetectable IgG2, and high levels of high-affinity IgE. The incidence of eczema was significantly higher in the latter pattern (84.6%), compared with the remaining infants (42.2%). Feeding practice-related allergen sensitization and immunoglobulin isotype formation were identified during the lactation period. The development of eczema during the lactation period could potentially modify the immunoglobulin isotype formation with high levels of high-affinity IgE."},"publication_date":"2019-06","publication_name":{"en":"Immunity, Inflammation and Disease","ja":"Immunity, Inflammation and Disease"},"volume":"Vol.7","number":"No.2","starting_page":"74","ending_page":"85","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1002/iid3.245"],"issn":["2050-4527"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/115659","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/31052301","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85065674765&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=351226","label":"url"}],"paper_title":{"en":"Associations of nutrient patterns with the prevalence of metabolic syndrome: Results from the baseline data of the Japan Multi-Institutional Collaborative Cohort Study","ja":"Associations of nutrient patterns with the prevalence of metabolic syndrome: Results from the baseline data of the Japan Multi-Institutional Collaborative Cohort Study"},"authors":{"en":[{"name":"Iwasaki Yuki"},{"name":"Arisawa Kokichi"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Uemura Hirokazu"},{"name":"Tsukamoto Mineko"},{"name":"Kadomatsu Yuka"},{"name":"Okada Rieko"},{"name":"Hishida Asahi"},{"name":"Tanaka Keitaro"},{"name":"Hara Megumi"},{"name":"Takezaki Toshiro"},{"name":"Shimatani Keiichi"},{"name":"Ozaki Etsuko"},{"name":"Koyama Teruhide"},{"name":"Suzuki Sadao"},{"name":"Nakagawa-Senda Hiroko"},{"name":"Kuriki Kiyonori"},{"name":"Miyagawa Naoko"},{"name":"Kadota Aya"},{"name":"Ikezaki Hiroaki"},{"name":"Furusyo Norihiro"},{"name":"Oze Isao"},{"name":"Ito Hidemi"},{"name":"Mikami Haruo"},{"name":"Nakamura Yohko"},{"name":"Wakai Kenji"}],"ja":[{"name":"岩﨑 夕貴"},{"name":"有澤 孝吉"},{"name":"勝浦-釜野 桜子"},{"name":"上村 浩一"},{"name":"Tsukamoto Mineko"},{"name":"Kadomatsu Yuka"},{"name":"Okada Rieko"},{"name":"Hishida Asahi"},{"name":"Tanaka Keitaro"},{"name":"Hara Megumi"},{"name":"Takezaki Toshiro"},{"name":"Shimatani Keiichi"},{"name":"Ozaki Etsuko"},{"name":"Koyama Teruhide"},{"name":"Suzuki Sadao"},{"name":"Nakagawa-Senda Hiroko"},{"name":"Kuriki Kiyonori"},{"name":"Miyagawa Naoko"},{"name":"Kadota Aya"},{"name":"Ikezaki Hiroaki"},{"name":"Furusyo Norihiro"},{"name":"Oze Isao"},{"name":"Ito Hidemi"},{"name":"Mikami Haruo"},{"name":"Nakamura Yohko"},{"name":"Wakai Kenji"}]},"description":{"en":"The association between nutrient patterns and metabolic syndrome (MetS) has not been examined in a Japanese population. A cross-sectional study was performed on 30,108 participants (aged 35-69 years) in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. Dietary intake was assessed using a 46-item food frequency questionnaire. MetS was diagnosed according to the Joint Interim Statement Criteria of 2009, using body mass index instead of waist circumference. Factor analysis was applied to energy-adjusted intake of 21 nutrients, and three nutrient patterns were extracted: Factor 1 (fiber, potassium and vitamins pattern); Factor 2 (fats and fat-soluble vitamins pattern); and Factor 3 (saturated fatty acids, calcium and vitamin B pattern). In multiple logistic regression analysis adjusted for sex, age, and other potential confounders, Factor 1 scores were associated with a significantly reduced odds ratio (OR) of MetS and all five components. Factor 2 scores were associated with significantly increased prevalence of MetS, obesity, and high blood pressure. Factor 3 scores were significantly associated with lower OR of MetS, high blood pressure, high serum triglycerides and low HDL cholesterol levels. Analysis of nutrient patterns may be useful to assess the overall quality of diet and its association with MetS.","ja":"The association between nutrient patterns and metabolic syndrome (MetS) has not been examined in a Japanese population. A cross-sectional study was performed on 30,108 participants (aged 35-69 years) in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. Dietary intake was assessed using a 46-item food frequency questionnaire. MetS was diagnosed according to the Joint Interim Statement Criteria of 2009, using body mass index instead of waist circumference. Factor analysis was applied to energy-adjusted intake of 21 nutrients, and three nutrient patterns were extracted: Factor 1 (fiber, potassium and vitamins pattern); Factor 2 (fats and fat-soluble vitamins pattern); and Factor 3 (saturated fatty acids, calcium and vitamin B pattern). In multiple logistic regression analysis adjusted for sex, age, and other potential confounders, Factor 1 scores were associated with a significantly reduced odds ratio (OR) of MetS and all five components. Factor 2 scores were associated with significantly increased prevalence of MetS, obesity, and high blood pressure. Factor 3 scores were significantly associated with lower OR of MetS, high blood pressure, high serum triglycerides and low HDL cholesterol levels. Analysis of nutrient patterns may be useful to assess the overall quality of diet and its association with MetS."},"publication_date":"2019-04-26","publication_name":{"en":"Nutrients","ja":"Nutrients"},"volume":"Vol.11","number":"No.5","starting_page":"990","ending_page":"990","languages":["eng"],"referee":true,"identifiers":{"doi":["10.3390/nu11050990"],"issn":["2072-6643"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/31011988","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85064647979&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=351219","label":"url"}],"paper_title":{"en":"Independent relationships of daily life activity and leisure-time exercise with metabolic syndrome and its traits in the general Japanese population.","ja":"Independent relationships of daily life activity and leisure-time exercise with metabolic syndrome and its traits in the general Japanese population."},"authors":{"en":[{"name":"Uemura Hirokazu"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Iwasaki Yuki"},{"name":"Arisawa Kokichi"},{"name":"Hishida Asahi"},{"name":"Okada Rieko"},{"name":"Tamura Takashi"},{"name":"Kubo Yoko"},{"name":"Ito Hidemi"},{"name":"Oze Isao"},{"name":"Shimanoe Chisato"},{"name":"Nishida Yuichiro"},{"name":"Nakamura Yasuyuki"},{"name":"Takashima Naoyuki"},{"name":"Suzuki Sadao"},{"name":"Nakagawa-Senda Hiroko"},{"name":"Nishimoto Daisaku"},{"name":"Takezaki Toshiro"},{"name":"Mikami Haruo"},{"name":"Nakamura Yohko"},{"name":"Furusyo Norihiro"},{"name":"Ikezaki Hiroaki"},{"name":"Ozaki Etsuko"},{"name":"Koyama Teruhide"},{"name":"Kuriki Kiyonori"},{"name":"Endoh Kaori"},{"name":"Naito Mariko"},{"name":"Wakai Kenji"}],"ja":[{"name":"上村 浩一"},{"name":"勝浦-釜野 桜子"},{"name":"岩﨑 夕貴"},{"name":"有澤 孝吉"},{"name":"Hishida Asahi"},{"name":"Okada Rieko"},{"name":"Tamura Takashi"},{"name":"Kubo Yoko"},{"name":"Ito Hidemi"},{"name":"Oze Isao"},{"name":"Shimanoe Chisato"},{"name":"Nishida Yuichiro"},{"name":"Nakamura Yasuyuki"},{"name":"Takashima Naoyuki"},{"name":"Suzuki Sadao"},{"name":"Nakagawa-Senda Hiroko"},{"name":"Nishimoto Daisaku"},{"name":"Takezaki Toshiro"},{"name":"Mikami Haruo"},{"name":"Nakamura Yohko"},{"name":"Furusyo Norihiro"},{"name":"Ikezaki Hiroaki"},{"name":"Ozaki Etsuko"},{"name":"Koyama Teruhide"},{"name":"Kuriki Kiyonori"},{"name":"Endoh Kaori"},{"name":"Naito Mariko"},{"name":"Wakai Kenji"}]},"description":{"en":"Our results suggest that higher daily life activity and higher moderate-intensity exercise may be independently associated with a lower risk of metabolic syndrome in Japanese adults.","ja":"Our results suggest that higher daily life activity and higher moderate-intensity exercise may be independently associated with a lower risk of metabolic syndrome in Japanese adults."},"publication_date":"2019-04-22","publication_name":{"en":"Endocrine","ja":"Endocrine"},"volume":"Vol.64","number":"No.3","starting_page":"552","ending_page":"563","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s12020-019-01926-9"],"issn":["1559-0100"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/115068","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/30993211","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85068744369&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=351224","label":"url"}],"paper_title":{"en":"Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals.","ja":"Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals."},"authors":{"en":[{"name":"Nakatochi Masahiro"},{"name":"Kanai Masahiro"},{"name":"Nakayama Akiyoshi"},{"name":"Hishida Asahi"},{"name":"Kawamura Yusuke"},{"name":"Ichihara Sahoko"},{"name":"Akiyama Masato"},{"name":"Ikezaki Hiroaki"},{"name":"Furusyo Norihiro"},{"name":"Shimizu Seiko"},{"name":"Yamamoto Ken"},{"name":"Hirata Makoto"},{"name":"Okada Rieko"},{"name":"Kawai Sayo"},{"name":"Kawaguchi Makoto"},{"name":"Nishida Yuichiro"},{"name":"Shimanoe Chisato"},{"name":"Ibusuki Rie"},{"name":"Takezaki Toshiro"},{"name":"Nakajima Mayuko"},{"name":"Takao Mikiya"},{"name":"Ozaki Etsuko"},{"name":"Matsui Daisuke"},{"name":"Nishiyama Takeshi"},{"name":"Suzuki Sadao"},{"name":"Takashima Naoyuki"},{"name":"Kita Yoshikuni"},{"name":"Endoh Kaori"},{"name":"Kuriki Kiyonori"},{"name":"Uemura Hirokazu"},{"name":"Arisawa Kokichi"},{"name":"Oze Isao"},{"name":"Matsuo Keitaro"},{"name":"Nakamura Yohko"},{"name":"Mikami Haruo"},{"name":"Tamura Takashi"},{"name":"Nakashima Hiroshi"},{"name":"Nakamura Takahiro"},{"name":"Kato Norihiro"},{"name":"Matsuda Koichi"},{"name":"Murakami Yoshinori"},{"name":"Matsubara Tatsuaki"},{"name":"Naito Mariko"},{"name":"Kubo Michiaki"},{"name":"Kamatani Yoichiro"},{"name":"Shinomiya Nariyoshi"},{"name":"Yokota Mitsuhiro"},{"name":"Wakai Kenji"},{"name":"Okada Yukinori"},{"name":"Matsuo Hirotaka"}],"ja":[{"name":"Nakatochi Masahiro"},{"name":"Kanai Masahiro"},{"name":"Nakayama Akiyoshi"},{"name":"Hishida Asahi"},{"name":"Kawamura Yusuke"},{"name":"Ichihara Sahoko"},{"name":"Akiyama Masato"},{"name":"Ikezaki Hiroaki"},{"name":"Furusyo Norihiro"},{"name":"Shimizu Seiko"},{"name":"Yamamoto Ken"},{"name":"Hirata Makoto"},{"name":"Okada Rieko"},{"name":"Kawai Sayo"},{"name":"Kawaguchi Makoto"},{"name":"Nishida Yuichiro"},{"name":"Shimanoe Chisato"},{"name":"Ibusuki Rie"},{"name":"Takezaki Toshiro"},{"name":"Nakajima Mayuko"},{"name":"Takao Mikiya"},{"name":"Ozaki Etsuko"},{"name":"Matsui Daisuke"},{"name":"Nishiyama Takeshi"},{"name":"Suzuki Sadao"},{"name":"Takashima Naoyuki"},{"name":"Kita Yoshikuni"},{"name":"Endoh Kaori"},{"name":"Kuriki Kiyonori"},{"name":"上村 浩一"},{"name":"有澤 孝吉"},{"name":"Oze Isao"},{"name":"Matsuo Keitaro"},{"name":"Nakamura Yohko"},{"name":"Mikami Haruo"},{"name":"Tamura Takashi"},{"name":"Nakashima Hiroshi"},{"name":"Nakamura Takahiro"},{"name":"Kato Norihiro"},{"name":"Matsuda Koichi"},{"name":"Murakami Yoshinori"},{"name":"Matsubara Tatsuaki"},{"name":"Naito Mariko"},{"name":"Kubo Michiaki"},{"name":"Kamatani Yoichiro"},{"name":"Shinomiya Nariyoshi"},{"name":"Yokota Mitsuhiro"},{"name":"Wakai Kenji"},{"name":"Okada Yukinori"},{"name":"Matsuo Hirotaka"}]},"description":{"en":"Gout is a common arthritis caused by elevated serum uric acid (SUA) levels. Here we investigated loci influencing SUA in a genome-wide meta-analysis with 121,745 Japanese subjects. We identified 8948 variants at 36 genomic loci (<5 × 10) including eight novel loci. Of these, missense variants of and were predicted to be damaging to the function of these proteins; another five loci-, , , , and -are related to cell metabolism, proliferation, or oxidative stress; and the remaining locus, , is unknown. We also identified 132 correlated genes whose expression levels are associated with SUA-increasing alleles. These genes are enriched for the UniProt transport term, suggesting the importance of transport-related genes in SUA regulation. Furthermore, trans-ethnic meta-analysis across our own meta-analysis and the Global Urate Genetics Consortium has revealed 15 more novel loci associated with SUA. Our findings provide insight into the pathogenesis, treatment, and prevention of hyperuricemia/gout.","ja":"Gout is a common arthritis caused by elevated serum uric acid (SUA) levels. Here we investigated loci influencing SUA in a genome-wide meta-analysis with 121,745 Japanese subjects. We identified 8948 variants at 36 genomic loci (<5 × 10) including eight novel loci. Of these, missense variants of and were predicted to be damaging to the function of these proteins; another five loci-, , , , and -are related to cell metabolism, proliferation, or oxidative stress; and the remaining locus, , is unknown. We also identified 132 correlated genes whose expression levels are associated with SUA-increasing alleles. These genes are enriched for the UniProt transport term, suggesting the importance of transport-related genes in SUA regulation. Furthermore, trans-ethnic meta-analysis across our own meta-analysis and the Global Urate Genetics Consortium has revealed 15 more novel loci associated with SUA. Our findings provide insight into the pathogenesis, treatment, and prevention of hyperuricemia/gout."},"publication_date":"2019-04-08","publication_name":{"en":"Communications Biology","ja":"Communications Biology"},"volume":"Vol.2","starting_page":"115","ending_page":"115","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1038/s42003-019-0339-0"],"issn":["2399-3642"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/114540","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/30630405","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=352741","label":"url"}],"paper_title":{"en":"Dioxins levels in human blood after implementation of measures against dioxin exposure in Japan","ja":"Dioxins levels in human blood after implementation of measures against dioxin exposure in Japan"},"authors":{"en":[{"name":"Muzembo Andre Basilua"},{"name":"Iwai-shimada Miyuki"},{"name":"Isobe Tomohiko"},{"name":"Arisawa Kokichi"},{"name":"Shima Masayuki"},{"name":"Fukushima Tetsuhito"},{"name":"Nakayama F. Shoji"}],"ja":[{"name":"Muzembo Andre Basilua"},{"name":"Iwai-shimada Miyuki"},{"name":"Isobe Tomohiko"},{"name":"有澤 孝吉"},{"name":"Shima Masayuki"},{"name":"Fukushima Tetsuhito"},{"name":"Nakayama F. Shoji"}]},"description":{"en":"Over the past few decades, the Japanese Ministry of the Environment has been biomonitoring dioxins in the general Japanese population and, in response to public concerns, has taken measures to reduce dioxin exposure. The objectives of this study were to assess the current dioxin dietary intake and corresponding body burden in the Japanese and compare Japanese dioxin data from 2011 to 2016 and 2002-2010 surveys. We also examined the relationship between blood dioxins and health parameters/clinical biomarkers. From 2011 to 2016, cross-sectional dioxin surveys were conducted on 490 Japanese (242 males and 248 females, aged 49.9 ± 7.6 years) from 15 Japanese prefectures. Blood (n = 490) and food samples (n = 90) were measured for 29 dioxin congeners including polychlorinated dibenzo-para-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and coplanar polychlorinated biphenyls (Co-PCBs) using gas chromatography coupled with high-resolution mass spectrometry. Using the 2006 World Health Organization toxic equivalence factors, the toxic equivalents (TEQs) were calculated. Clinical biomarkers and anthropometric parameters were also measured and information on lifestyle behaviours collected. Data imputations were applied to account for blood dioxins below the detection limit. The median (95% confidence interval or CI) blood levels and dioxin dietary intake was respectively 9.4 (8.8-9.9) pg TEQ/g lipid and 0.3 (0.2-0.4) pg TEQ/kg body weight/day. The median blood dioxin level in the 2011-2016 survey was found to have decreased by 41.3% compared to the 2002-2010 surveys. Participants who were older were found to be more likely to have higher dioxin levels. Blood dioxins were also significantly associated with body mass index, triglycerides, docosahexaenoic acid, eicosapentaenoic acid, and dihomo-gamma-linoleic acid levels in blood. Furthermore, associations between blood dioxin and dietary dioxin intake were evident in the unadjusted models. However, after adjusting for confounders, blood dioxins were not found to be associated with dietary dioxin intake. Blood dioxin levels declined over the past decade. This study showed that the measures and actions undertaken in Japan have possibly contributed to these reductions in the body burden of dioxins in the Japanese population.","ja":"Over the past few decades, the Japanese Ministry of the Environment has been biomonitoring dioxins in the general Japanese population and, in response to public concerns, has taken measures to reduce dioxin exposure. The objectives of this study were to assess the current dioxin dietary intake and corresponding body burden in the Japanese and compare Japanese dioxin data from 2011 to 2016 and 2002-2010 surveys. We also examined the relationship between blood dioxins and health parameters/clinical biomarkers. From 2011 to 2016, cross-sectional dioxin surveys were conducted on 490 Japanese (242 males and 248 females, aged 49.9 ± 7.6 years) from 15 Japanese prefectures. Blood (n = 490) and food samples (n = 90) were measured for 29 dioxin congeners including polychlorinated dibenzo-para-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and coplanar polychlorinated biphenyls (Co-PCBs) using gas chromatography coupled with high-resolution mass spectrometry. Using the 2006 World Health Organization toxic equivalence factors, the toxic equivalents (TEQs) were calculated. Clinical biomarkers and anthropometric parameters were also measured and information on lifestyle behaviours collected. Data imputations were applied to account for blood dioxins below the detection limit. The median (95% confidence interval or CI) blood levels and dioxin dietary intake was respectively 9.4 (8.8-9.9) pg TEQ/g lipid and 0.3 (0.2-0.4) pg TEQ/kg body weight/day. The median blood dioxin level in the 2011-2016 survey was found to have decreased by 41.3% compared to the 2002-2010 surveys. Participants who were older were found to be more likely to have higher dioxin levels. Blood dioxins were also significantly associated with body mass index, triglycerides, docosahexaenoic acid, eicosapentaenoic acid, and dihomo-gamma-linoleic acid levels in blood. Furthermore, associations between blood dioxin and dietary dioxin intake were evident in the unadjusted models. However, after adjusting for confounders, blood dioxins were not found to be associated with dietary dioxin intake. Blood dioxin levels declined over the past decade. This study showed that the measures and actions undertaken in Japan have possibly contributed to these reductions in the body burden of dioxins in the Japanese population."},"publication_date":"2019-01-10","publication_name":{"en":"Environmental Health and Preventive Medicine","ja":"Environmental Health and Preventive Medicine"},"volume":"Vol.24","number":"No.1","starting_page":"6","ending_page":"6","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1186/s12199-018-0755-7"],"issn":["1347-4715"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/30611367","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85058150155&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=349291","label":"url"}],"paper_title":{"en":"Cumulative Incidence of Osteochondritis Dissecans of the Capitellum in Preadolescent Baseball Players.","ja":"Cumulative Incidence of Osteochondritis Dissecans of the Capitellum in Preadolescent Baseball Players."},"authors":{"en":[{"name":"Matsuura Tetsuya"},{"name":"Iwame Toshiyuki"},{"name":"Suzue Naoto"},{"name":"Takao Shoichiro"},{"name":"Nishio Susumu"},{"name":"Arisawa Kokichi"},{"name":"Sairyo Koichi"}],"ja":[{"name":"松浦 哲也"},{"name":"岩目 敏幸"},{"name":"鈴江 直人"},{"name":"髙尾 正一郎"},{"name":"Nishio Susumu"},{"name":"有澤 孝吉"},{"name":"西良 浩一"}]},"description":{"en":"Level III, local nonrandom sample cohort.","ja":"The risk of OCD of the capitellum developing within a 1-year period in preadolescent baseball players was 1.8%. Players aged 10 to 11 years had a significantly greater risk of capitellar OCD development than those aged 6 to 9 years."},"publication_date":"2019-01","publication_name":{"en":"Arthroscopy : the Journal of Arthroscopic & Related Surgery","ja":"Arthroscopy : the Journal of Arthroscopic & Related Surgery"},"volume":"Vol.35","number":"No.1","starting_page":"60","ending_page":"66","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.arthro.2018.08.034"],"issn":["1526-3231"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/30102679","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=352743","label":"url"}],"paper_title":{"en":"Genomewide Association Study of Leisure-Time Exercise Behavior in Japanese Adults","ja":"Genomewide Association Study of Leisure-Time Exercise Behavior in Japanese Adults"},"authors":{"en":[{"name":"Hara M"},{"name":"Hachiya T"},{"name":"Sutoh Y"},{"name":"Matsuo K"},{"name":"Nishida Y"},{"name":"Shimanoe C"},{"name":"Tanaka K"},{"name":"Shimizu A"},{"name":"Ohnaka K"},{"name":"Kawaguchi T"},{"name":"Oze I"},{"name":"Matsuda F"},{"name":"Ito H"},{"name":"Kawai S"},{"name":"Hishida A"},{"name":"Okada R"},{"name":"Sasakabe T"},{"name":"Hirata A"},{"name":"Ibusuki R"},{"name":"Nindita Y"},{"name":"Furusyo N"},{"name":"Ikezaki H"},{"name":"Kuriyama N"},{"name":"Ozaki E"},{"name":"Mikami H"},{"name":"Nakamura Y"},{"name":"Suzuki S"},{"name":"Hosono A"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Arisawa Kokichi"},{"name":"Kuriki K"},{"name":"Endoh K"},{"name":"Takashima N"},{"name":"Kadota A"},{"name":"Nakatochi M"},{"name":"Momozawa Y"},{"name":"Kubo M"},{"name":"Naito M"},{"name":"Wakai K"}],"ja":[{"name":"Hara M"},{"name":"Hachiya T"},{"name":"Sutoh Y"},{"name":"Matsuo K"},{"name":"Nishida Y"},{"name":"Shimanoe C"},{"name":"Tanaka K"},{"name":"Shimizu A"},{"name":"Ohnaka K"},{"name":"Kawaguchi T"},{"name":"Oze I"},{"name":"Matsuda F"},{"name":"Ito H"},{"name":"Kawai S"},{"name":"Hishida A"},{"name":"Okada R"},{"name":"Sasakabe T"},{"name":"Hirata A"},{"name":"Ibusuki R"},{"name":"Nindita Y"},{"name":"Furusyo N"},{"name":"Ikezaki H"},{"name":"Kuriyama N"},{"name":"Ozaki E"},{"name":"Mikami H"},{"name":"Nakamura Y"},{"name":"Suzuki S"},{"name":"Hosono A"},{"name":"勝浦-釜野 桜子"},{"name":"有澤 孝吉"},{"name":"Kuriki K"},{"name":"Endoh K"},{"name":"Takashima N"},{"name":"Kadota A"},{"name":"Nakatochi M"},{"name":"Momozawa Y"},{"name":"Kubo M"},{"name":"Naito M"},{"name":"Wakai K"}]},"description":{"en":"Although several genetic factors may play a role in leisure-time exercise behavior, there is currently no evidence of a significant genomewide association, and candidate gene replication studies have produced inconsistent results. We conducted a two-stage genomewide association study and candidate single-nucleotide polymorphisms (SNP) association study on leisure-time exercise behavior using 13,980 discovery samples from the Japan Multi-Institutional Collaborative Cohort (J-MICC) study, and 2036 replication samples from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center-2 study. Leisure-time physical activity was measured using a self-administered questionnaire that inquired about the type, frequency and duration of exercise. Participants with ≥4 MET·h·wk of leisure-time physical activity were defined as exhibiting leisure-time exercise behavior. Association testing using mixed linear regression models was performed on the discovery and replication samples, after which the results were combined in a meta-analysis. In addition, we tested six candidate genetic variants derived from previous genomewide association study. We found that one novel SNP (rs10252228) located in the intergenic region between NPSR1 and DPY19L1 was significantly associated with leisure-time exercise behavior in discovery samples. This association was also significant in replication samples (combined P value by meta-analysis = 2.2 × 10). Several SNP linked with rs10252228 were significantly associated with gene expression of DPY19L1 and DP19L2P1 in skeletal muscle, heart, whole blood, and the nervous system. Among the candidate SNP, rs12612420 in DNAPTP6 demonstrated nominal significance in discovery samples but not in replication samples. We identified a novel genetic variant associated with regular leisure-time exercise behavior. Further functional studies are required to validate the role of these variants in exercise behavior.","ja":"Although several genetic factors may play a role in leisure-time exercise behavior, there is currently no evidence of a significant genomewide association, and candidate gene replication studies have produced inconsistent results. We conducted a two-stage genomewide association study and candidate single-nucleotide polymorphisms (SNP) association study on leisure-time exercise behavior using 13,980 discovery samples from the Japan Multi-Institutional Collaborative Cohort (J-MICC) study, and 2036 replication samples from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center-2 study. Leisure-time physical activity was measured using a self-administered questionnaire that inquired about the type, frequency and duration of exercise. Participants with ≥4 MET·h·wk of leisure-time physical activity were defined as exhibiting leisure-time exercise behavior. Association testing using mixed linear regression models was performed on the discovery and replication samples, after which the results were combined in a meta-analysis. In addition, we tested six candidate genetic variants derived from previous genomewide association study. We found that one novel SNP (rs10252228) located in the intergenic region between NPSR1 and DPY19L1 was significantly associated with leisure-time exercise behavior in discovery samples. This association was also significant in replication samples (combined P value by meta-analysis = 2.2 × 10). Several SNP linked with rs10252228 were significantly associated with gene expression of DPY19L1 and DP19L2P1 in skeletal muscle, heart, whole blood, and the nervous system. Among the candidate SNP, rs12612420 in DNAPTP6 demonstrated nominal significance in discovery samples but not in replication samples. We identified a novel genetic variant associated with regular leisure-time exercise behavior. Further functional studies are required to validate the role of these variants in exercise behavior."},"publication_date":"2018-12","publication_name":{"en":"Medicine and Science in Sports and Exercise","ja":"Medicine and Science in Sports and Exercise"},"volume":"Vol.50","number":"No.12","starting_page":"2433","ending_page":"2441","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1249/MSS.0000000000001712"],"issn":["0195-9131"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/115592","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/30508907","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=352742","label":"url"}],"paper_title":{"en":"Association of exposure level to passive smoking with hypertension among lifetime nonsmokers in Japan: a cross-sectional study","ja":"Association of exposure level to passive smoking with hypertension among lifetime nonsmokers in Japan: a cross-sectional study"},"authors":{"en":[{"name":"Tamura T"},{"name":"Kadomatsu Y"},{"name":"Tsukamoto M"},{"name":"Okada R"},{"name":"Sasakabe T"},{"name":"Kawai S"},{"name":"Hishida A"},{"name":"Hara M"},{"name":"Tanaka K"},{"name":"Shimoshikiryo I"},{"name":"Takezaki T"},{"name":"Watanabe I"},{"name":"Matsui D"},{"name":"Nishiyama T"},{"name":"Suzuki S"},{"name":"Endoh K"},{"name":"Kuriki K"},{"name":"Kita Y"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Arisawa Kokichi"},{"name":"Ikezaki H"},{"name":"Furusyo N"},{"name":"Koyanagi YN"},{"name":"Oze I"},{"name":"Nakamura Y"},{"name":"Mikami H"},{"name":"Naito M"},{"name":"Wakai K"},{"name":".Japan Multi-Institutional Collaborative Cohort (J-MICC) Study"}],"ja":[{"name":"Tamura T"},{"name":"Kadomatsu Y"},{"name":"Tsukamoto M"},{"name":"Okada R"},{"name":"Sasakabe T"},{"name":"Kawai S"},{"name":"Hishida A"},{"name":"Hara M"},{"name":"Tanaka K"},{"name":"Shimoshikiryo I"},{"name":"Takezaki T"},{"name":"Watanabe I"},{"name":"Matsui D"},{"name":"Nishiyama T"},{"name":"Suzuki S"},{"name":"Endoh K"},{"name":"Kuriki K"},{"name":"Kita Y"},{"name":"勝浦-釜野 桜子"},{"name":"有澤 孝吉"},{"name":"Ikezaki H"},{"name":"Furusyo N"},{"name":"Koyanagi YN"},{"name":"Oze I"},{"name":"Nakamura Y"},{"name":"Mikami H"},{"name":"Naito M"},{"name":"Wakai K"},{"name":".Japan Multi-Institutional Collaborative Cohort (J-MICC) Study"}]},"description":{"en":"Brief exposure to passive smoking immediately elevates blood pressure. However, little is known about the association between exposure to passive smoking and chronic hypertension. We aimed to examine this association in a cross-sectional study, after controlling multiple potential confounders.Participants included 32,098 lifetime nonsmokers (7,216 men and 24,882 women) enrolled in the Japan Multi-Institutional Collaborative Cohort Study. Passive smoking was assessed using a self-administered questionnaire. The single question about exposure to passive smoking had five response options: \"sometimes or almost never,\" \"almost every day, 2 hours/day or less,\" \"almost every day, 2 to 4 hours/day,\" \"almost every day, 4 to 6 hours/day,\" and \"almost every day, 6 hours/day or longer.\" Hypertension was defined as any of the following: systolic blood pressure ≥140 mmHg, diastolic blood pressure ≥90 mmHg, or use of antihypertensive medication. Multivariate-adjusted odds ratio (OR) and 95% confidence interval (CI) for hypertension were estimated by exposure level to passive smoking using unconditional logistic regression models.The multivariate-adjusted OR for hypertension in those exposed almost every day was 1.11 (95% CI: 1.03-1.20) compared with those exposed sometimes or almost never. The OR for a 1-hour per day increase in exposure was 1.03 (95% CI: 1.01-1.06, Pfor trend = .006). This association was stronger in men than in women; the ORs were 1.08 (95% CI: 1.01-1.15, Pfor trend = .036) and 1.03 (95% CI: 1.00-1.05, Pfor trend = .055), respectively.Our findings suggest importance of tobacco smoke control for preventing hypertension.","ja":"Brief exposure to passive smoking immediately elevates blood pressure. However, little is known about the association between exposure to passive smoking and chronic hypertension. We aimed to examine this association in a cross-sectional study, after controlling multiple potential confounders.Participants included 32,098 lifetime nonsmokers (7,216 men and 24,882 women) enrolled in the Japan Multi-Institutional Collaborative Cohort Study. Passive smoking was assessed using a self-administered questionnaire. The single question about exposure to passive smoking had five response options: \"sometimes or almost never,\" \"almost every day, 2 hours/day or less,\" \"almost every day, 2 to 4 hours/day,\" \"almost every day, 4 to 6 hours/day,\" and \"almost every day, 6 hours/day or longer.\" Hypertension was defined as any of the following: systolic blood pressure ≥140 mmHg, diastolic blood pressure ≥90 mmHg, or use of antihypertensive medication. Multivariate-adjusted odds ratio (OR) and 95% confidence interval (CI) for hypertension were estimated by exposure level to passive smoking using unconditional logistic regression models.The multivariate-adjusted OR for hypertension in those exposed almost every day was 1.11 (95% CI: 1.03-1.20) compared with those exposed sometimes or almost never. The OR for a 1-hour per day increase in exposure was 1.03 (95% CI: 1.01-1.06, Pfor trend = .006). This association was stronger in men than in women; the ORs were 1.08 (95% CI: 1.01-1.15, Pfor trend = .036) and 1.03 (95% CI: 1.00-1.05, Pfor trend = .055), respectively.Our findings suggest importance of tobacco smoke control for preventing hypertension."},"publication_date":"2018-11","publication_name":{"en":"Medicine","ja":"Medicine"},"volume":"Vol.97","number":"No.48","starting_page":"e13241","ending_page":"e13241","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1097/MD.0000000000013241"],"issn":["1536-5964"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/112443","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/29941884","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=340200","label":"url"}],"paper_title":{"en":"Inverse association between soy food consumption, especially fermented soy products intake and soy isoflavone, and arterial stiffness in Japanese men.","ja":"Inverse association between soy food consumption, especially fermented soy products intake and soy isoflavone, and arterial stiffness in Japanese men."},"authors":{"en":[{"name":"Uemura Hirokazu"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Nakamoto Mariko"},{"name":"Yamaguchi Miwa"},{"name":"Fujioka Miho"},{"name":"Iwasaki Yuki"},{"name":"Arisawa Kokichi"}],"ja":[{"name":"上村 浩一"},{"name":"勝浦-釜野 桜子"},{"name":"中本 真理子"},{"name":"Yamaguchi Miwa"},{"name":"藤岡 美穂"},{"name":"岩﨑 夕貴"},{"name":"有澤 孝吉"}]},"description":{"en":"Studies on the associations between soy food consumption and arterial stiffness are rare. The aim of the present study was to evaluate their associations in Japanese men. A total of 652 eligible men, aged 35-69 years, who underwent the measurement of brachial-ankle pulse wave velocity (baPWV) as an index of arterial stiffness were evaluated in this cross-sectional study. Information on their lifestyle characteristics, including dietary behavior, was obtained from a structured self-administered questionnaire. The frequency of total soy products as well as fermented and non-fermented soy products intakes was calculated, and the amounts of soy protein and soy isoflavone intakes were also estimated; these were then divided into tertiles and their associations with baPWV values were evaluated using general linear models. Higher frequency of fermented soy products intake was associated with decreased baPWV after adjusting for the multivariable covariates (P value for trend was 0.002, in Model 3). This association did not alter after further adjustment with a biomarker of systemic inflammation (serum high-sensitivity C-reactive protein (hs-CRP)) (P value for trend was 0.001, in Model 4). Total soy isoflavone consumption was also inversely associated with baPWV even after adjusting for multivariable covariates including serum hs-CRP (P value for trend was 0.043, in Model 4); however total soy protein consumption was not. These results demonstrated that greater consumption of soy food, especially fermented soy products and soy isoflavone was associated with reduced arterial stiffness, independent of systemic inflammation, in Japanese men.","ja":"Studies on the associations between soy food consumption and arterial stiffness are rare. The aim of the present study was to evaluate their associations in Japanese men. A total of 652 eligible men, aged 35-69 years, who underwent the measurement of brachial-ankle pulse wave velocity (baPWV) as an index of arterial stiffness were evaluated in this cross-sectional study. Information on their lifestyle characteristics, including dietary behavior, was obtained from a structured self-administered questionnaire. The frequency of total soy products as well as fermented and non-fermented soy products intakes was calculated, and the amounts of soy protein and soy isoflavone intakes were also estimated; these were then divided into tertiles and their associations with baPWV values were evaluated using general linear models. Higher frequency of fermented soy products intake was associated with decreased baPWV after adjusting for the multivariable covariates (P value for trend was 0.002, in Model 3). This association did not alter after further adjustment with a biomarker of systemic inflammation (serum high-sensitivity C-reactive protein (hs-CRP)) (P value for trend was 0.001, in Model 4). Total soy isoflavone consumption was also inversely associated with baPWV even after adjusting for multivariable covariates including serum hs-CRP (P value for trend was 0.043, in Model 4); however total soy protein consumption was not. These results demonstrated that greater consumption of soy food, especially fermented soy products and soy isoflavone was associated with reduced arterial stiffness, independent of systemic inflammation, in Japanese men."},"publication_date":"2018-06-25","publication_name":{"en":"Scientific Reports","ja":"Scientific Reports"},"volume":"Vol.8","number":"No.1","starting_page":"9667","ending_page":"9667","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1038/s41598-018-28038-0"],"issn":["2045-2322"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/112230","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/30282853","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=339858","label":"url"}],"paper_title":{"en":"Recent decreasing trends of exposure to PCDDs/PCDFs/dioxin-like PCBs in general populations, and associations with diabetes, metabolic syndrome, and gout/hyperuricemia","ja":"Recent decreasing trends of exposure to PCDDs/PCDFs/dioxin-like PCBs in general populations, and associations with diabetes, metabolic syndrome, and gout/hyperuricemia"},"authors":{"en":[{"name":"Arisawa Kokichi"}],"ja":[{"name":"有澤 孝吉"}]},"description":{"en":"The author reviewed recent reports about the blood levels and dietary intake of polychlorinated dibenzo-p-dioxins (PCDDs)/furans (PCDFs)/dioxin-like polychlorinated biphenyls (DL-PCBs) to investigate the trends of dioxin exposure, and epidemiologic studies on the associations of blood levels of dioxins with metabolic diseases. In recent years, dietary intake of dioxins has been decreasing, and the means are equal to or less than 1.0 pg Toxic Equivalents (TEQ)/kg/day in the general populations of several countries. The blood levels of dioxins are also decreasing, probably because of reduced dietary intake. Many cross-sectional studies reported positive associations between blood levels of some isomers or TEQ-based concentrations of PCDDs/PCDFs/DL-PCBs and diabetes in general populations. Three cohort studies on populations with heavy exposure and two nested case-control studies on general populations have also been published, but the results are inconsistent. Three large-scale cross-sectional studies and two cohort studies reported an association between blood levels of some isomers or TEQ-based concentrations of PCDDs/PCDFs/DL-PCBs and metabolic syndrome. In addition, three cross-sectional studies reported significant positive associations with gout/hyperuricemia. Further prospective studies and experimental studies are needed to establish cause-effect relationships, and to clarify the biological mechanisms for the association between background exposure to dioxins and potential health effects. J. Med. Invest. 65:151-161, August, 2018.","ja":"The author reviewed recent reports about the blood levels and dietary intake of polychlorinated dibenzo-p-dioxins (PCDDs)/furans (PCDFs)/dioxin-like polychlorinated biphenyls (DL-PCBs) to investigate the trends of dioxin exposure, and epidemiologic studies on the associations of blood levels of dioxins with metabolic diseases. In recent years, dietary intake of dioxins has been decreasing, and the means are equal to or less than 1.0 pg Toxic Equivalents (TEQ)/kg/day in the general populations of several countries. The blood levels of dioxins are also decreasing, probably because of reduced dietary intake. Many cross-sectional studies reported positive associations between blood levels of some isomers or TEQ-based concentrations of PCDDs/PCDFs/DL-PCBs and diabetes in general populations. Three cohort studies on populations with heavy exposure and two nested case-control studies on general populations have also been published, but the results are inconsistent. Three large-scale cross-sectional studies and two cohort studies reported an association between blood levels of some isomers or TEQ-based concentrations of PCDDs/PCDFs/DL-PCBs and metabolic syndrome. In addition, three cross-sectional studies reported significant positive associations with gout/hyperuricemia. Further prospective studies and experimental studies are needed to establish cause-effect relationships, and to clarify the biological mechanisms for the association between background exposure to dioxins and potential health effects. J. Med. Invest. 65:151-161, August, 2018."},"publication_date":"2018-06-14","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.65","number":"No.3.4","starting_page":"151","ending_page":"161","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.65.151"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/29337417","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85042582939&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=339859","label":"url"}],"paper_title":{"en":"Guillan-Barre syndrome in local area in Japan, 2006-2015: an epidemiological and clinical study of 108 patients","ja":"Guillan-Barre syndrome in local area in Japan, 2006-2015: an epidemiological and clinical study of 108 patients"},"authors":{"en":[{"name":"Matsui Naoko"},{"name":"Nodera Hiroyuki"},{"name":"Kuzume D"},{"name":"Iwasa N"},{"name":"Unai Y"},{"name":"Sakai W"},{"name":"Miyazaki Y"},{"name":"Yamazaki H"},{"name":"Osaki Yusuke"},{"name":"Mori A"},{"name":"Furukawa T"},{"name":"Tsukamoto-Miyashiro A"},{"name":"Shimatani Y"},{"name":"Yamasaki M"},{"name":"Izumi Yuishin"},{"name":"Kusunoki S"},{"name":"Arisawa Kokichi"},{"name":"Kaji Ryuji"}],"ja":[{"name":"松井 尚子"},{"name":"野寺 裕之"},{"name":"Kuzume D"},{"name":"Iwasa N"},{"name":"Unai Y"},{"name":"Sakai W"},{"name":"Miyazaki Y"},{"name":"Yamazaki H"},{"name":"大崎 裕亮"},{"name":"Mori A"},{"name":"Furukawa T"},{"name":"Tsukamoto-Miyashiro A"},{"name":"Shimatani Y"},{"name":"Yamasaki M"},{"name":"和泉 唯信"},{"name":"Kusunoki S"},{"name":"有澤 孝吉"},{"name":"梶 龍兒"}]},"description":{"en":"Many epidemiological studies of Guillain-Barré syndrome (GBS) and Fisher syndrome (FS) have been conducted in Europe and America. In contrast, epidemiological studies are rare in Asia where the GBS subtypes differ from those in Western countries. This study was undertaken to clarify the incidence of GBS and FS in a local area in Japan as well as their seasonal trends. Seventy-one GBS and 37 FS patients were recorded from 2006 to 2015 in an area of approximately 1.5 million inhabitants in Japan. The incidence, seasonal trends and clinical features of GBS and FS were examined. The incidence rate of GBS was 0.42 cases per 100 000 person-years and that of FS was 0.22 cases per 100 000 person-years. The incidence of GBS increased with age and FS affected predominantly patients aged from 45 to 64 years old. There was some seasonal clustering of acute motor axonal neuropathy (AMAN) and FS in spring and summer, but it was not significant. AMAN and FS patients had a high frequency of preceding infection (AMAN, 68% gastrointestinal infection; FS, 65% upper respiratory infection). Antecedent respiratory infection was significantly associated with FS as an outcome. Serum antibodies to ganglioside GM1 were detected in 71% of AMAN patients and antibodies to GQ1b were detected in 81% of FS patients. Our study offers evidence of a lower incidence of GBS and a higher incidence of FS in a local area in Japan than in Western countries.","ja":"Many epidemiological studies of Guillain-Barré syndrome (GBS) and Fisher syndrome (FS) have been conducted in Europe and America. In contrast, epidemiological studies are rare in Asia where the GBS subtypes differ from those in Western countries. This study was undertaken to clarify the incidence of GBS and FS in a local area in Japan as well as their seasonal trends. Seventy-one GBS and 37 FS patients were recorded from 2006 to 2015 in an area of approximately 1.5 million inhabitants in Japan. The incidence, seasonal trends and clinical features of GBS and FS were examined. The incidence rate of GBS was 0.42 cases per 100 000 person-years and that of FS was 0.22 cases per 100 000 person-years. The incidence of GBS increased with age and FS affected predominantly patients aged from 45 to 64 years old. There was some seasonal clustering of acute motor axonal neuropathy (AMAN) and FS in spring and summer, but it was not significant. AMAN and FS patients had a high frequency of preceding infection (AMAN, 68% gastrointestinal infection; FS, 65% upper respiratory infection). Antecedent respiratory infection was significantly associated with FS as an outcome. Serum antibodies to ganglioside GM1 were detected in 71% of AMAN patients and antibodies to GQ1b were detected in 81% of FS patients. Our study offers evidence of a lower incidence of GBS and a higher incidence of FS in a local area in Japan than in Western countries."},"publication_date":"2018-05-25","publication_name":{"en":"European Journal of Neurology","ja":"European Journal of Neurology"},"volume":"Vol.25","number":"No.5","starting_page":"718","ending_page":"724","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1111/ene.13569"],"issn":["1468-1331"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/29779033","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=339854","label":"url"}],"paper_title":{"en":"Genome-wide association study on renal function traits: Results from the Japan Multi-Institutional Collaborative Cohort Study","ja":"Genome-wide association study on renal function traits: Results from the Japan Multi-Institutional Collaborative Cohort Study"},"authors":{"en":[{"name":"Hishida A"},{"name":"Nakatochi M"},{"name":"Akiyama M"},{"name":"Kamatani Y"},{"name":"Nishiyama T"},{"name":"Ito H"},{"name":"Oze I"},{"name":"Nishida Y"},{"name":"Hara M"},{"name":"Takashima N"},{"name":"Turin TC"},{"name":"Watanabe M"},{"name":"Suzuki S"},{"name":"Ibusuki R"},{"name":"Shimoshikiryo I"},{"name":"Nakamura Y"},{"name":"Mikami H"},{"name":"Ikezaki H"},{"name":"Furusyo N"},{"name":"Kuriki K"},{"name":"Endoh K"},{"name":"Koyama T"},{"name":"Matsui D"},{"name":"Uemura Hirokazu"},{"name":"Arisawa Kokichi"},{"name":"Sasakabe T"},{"name":"Okada R"},{"name":"Kawai S"},{"name":"Naito M"},{"name":"Momozawa Y"},{"name":"Kubo M"},{"name":"Wakai K"},{"name":"Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group"}],"ja":[{"name":"Hishida A"},{"name":"Nakatochi M"},{"name":"Akiyama M"},{"name":"Kamatani Y"},{"name":"Nishiyama T"},{"name":"Ito H"},{"name":"Oze I"},{"name":"Nishida Y"},{"name":"Hara M"},{"name":"Takashima N"},{"name":"Turin TC"},{"name":"Watanabe M"},{"name":"Suzuki S"},{"name":"Ibusuki R"},{"name":"Shimoshikiryo I"},{"name":"Nakamura Y"},{"name":"Mikami H"},{"name":"Ikezaki H"},{"name":"Furusyo N"},{"name":"Kuriki K"},{"name":"Endoh K"},{"name":"Koyama T"},{"name":"Matsui D"},{"name":"上村 浩一"},{"name":"有澤 孝吉"},{"name":"Sasakabe T"},{"name":"Okada R"},{"name":"Kawai S"},{"name":"Naito M"},{"name":"Momozawa Y"},{"name":"Kubo M"},{"name":"Wakai K"},{"name":"Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group"}]},"description":{"en":"Chronic kidney disease (CKD) is a rapidly growing, worldwide public health problem. Recent advances in genome-wide-association studies (GWAS) revealed several genetic loci associated with renal function traits worldwide. We investigated the association of genetic factors with the levels of serum creatinine (SCr) and the estimated glomerular filtration rate (eGFR) in Japanese population-based cohorts analyzing the GWAS imputed data with 11,221 subjects and 12,617,569 variants, and replicated the findings with the 148,829 hospital-based Japanese subjects. In the discovery phase, 28 variants within 4 loci (chromosome [chr] 2 with 8 variants including rs3770636 in the LDL receptor related protein 2 gene locus, on chr 5 with 2 variants including rs270184, chr 17 with 15 variants including rs3785837 in the BCAS3 gene locus, and chr 18 with 3 variants including rs74183647 in the nuclear factor of -activated T-cells 1 gene locus) reached the suggestive level of p < 1 × 10-6 in association with eGFR and SCr, and 2 variants on chr 4 (including rs78351985 in the microsomal triglyceride transfer protein gene locus) fulfilled the suggestive level in association with the risk of CKD. In the replication phase, 25 variants within 3 loci (chr 2 with 7 variants, chr 17 with 15 variants and chr 18 with 3 variants) in association with eGFR and SCr, and 2 variants on chr 4 associated with the risk of CKD became nominally statistically significant after Bonferroni correction, among which 15 variants on chr 17 and 3 variants on chr 18 reached genome-wide significance of p < 5 × 10-8 in the combined study meta-analysis. The associations of the loci on chr 2 and 18 with eGFR and SCr as well as that on chr 4 with CKD risk have not been previously reported in the Japanese and East Asian populations. Although the present GWAS of renal function traits included the largest sample of Japanese participants to date, we did not identify novel loci for renal traits. However, we identified the novel associations of the genetic loci on chr 2, 4, and 18 with renal function traits in the Japanese population, suggesting these are transethnic loci. Further investigations of these associations are expected to further validate our findings for the potential establishment of personalized prevention of renal disease in the Japanese and East Asian populations.","ja":"Chronic kidney disease (CKD) is a rapidly growing, worldwide public health problem. Recent advances in genome-wide-association studies (GWAS) revealed several genetic loci associated with renal function traits worldwide. We investigated the association of genetic factors with the levels of serum creatinine (SCr) and the estimated glomerular filtration rate (eGFR) in Japanese population-based cohorts analyzing the GWAS imputed data with 11,221 subjects and 12,617,569 variants, and replicated the findings with the 148,829 hospital-based Japanese subjects. In the discovery phase, 28 variants within 4 loci (chromosome [chr] 2 with 8 variants including rs3770636 in the LDL receptor related protein 2 gene locus, on chr 5 with 2 variants including rs270184, chr 17 with 15 variants including rs3785837 in the BCAS3 gene locus, and chr 18 with 3 variants including rs74183647 in the nuclear factor of -activated T-cells 1 gene locus) reached the suggestive level of p < 1 × 10-6 in association with eGFR and SCr, and 2 variants on chr 4 (including rs78351985 in the microsomal triglyceride transfer protein gene locus) fulfilled the suggestive level in association with the risk of CKD. In the replication phase, 25 variants within 3 loci (chr 2 with 7 variants, chr 17 with 15 variants and chr 18 with 3 variants) in association with eGFR and SCr, and 2 variants on chr 4 associated with the risk of CKD became nominally statistically significant after Bonferroni correction, among which 15 variants on chr 17 and 3 variants on chr 18 reached genome-wide significance of p < 5 × 10-8 in the combined study meta-analysis. The associations of the loci on chr 2 and 18 with eGFR and SCr as well as that on chr 4 with CKD risk have not been previously reported in the Japanese and East Asian populations. Although the present GWAS of renal function traits included the largest sample of Japanese participants to date, we did not identify novel loci for renal traits. However, we identified the novel associations of the genetic loci on chr 2, 4, and 18 with renal function traits in the Japanese population, suggesting these are transethnic loci. Further investigations of these associations are expected to further validate our findings for the potential establishment of personalized prevention of renal disease in the Japanese and East Asian populations."},"publication_date":"2018-05-18","publication_name":{"en":"American Journal of Nephrology","ja":"American Journal of Nephrology"},"volume":"Vol.47","number":"No.5","starting_page":"305","ending_page":"314","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1159/000488946"],"issn":["1421-9670"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=339855","label":"url"}],"paper_title":{"en":"A genome-wide association study of coping behaviors suggests FBXO45 is associated with emotional espression","ja":"A genome-wide association study of coping behaviors suggests FBXO45 is associated with emotional espression"},"authors":{"en":[{"name":"Shimanoe C"},{"name":"Hachiya T"},{"name":"Hara M"},{"name":"Nishida Y"},{"name":"Tanaka K"},{"name":"Sutoh Y"},{"name":"Shimizu A"},{"name":"Hishida R"},{"name":"Kawai S"},{"name":"Okada R"},{"name":"Tamura T"},{"name":"Matsuo K"},{"name":"Ito H"},{"name":"Ozaki E"},{"name":"Matsui D"},{"name":"Ibuseki R"},{"name":"Shimoshikiryo I"},{"name":"Takashima N"},{"name":"Kadota A"},{"name":"Arisawa Kokichi"},{"name":"Uemura Hirokazu"},{"name":"Suzuki S"},{"name":"Watanabe M"},{"name":"Kuriki K"},{"name":"Endoh K"},{"name":"Mikami H"},{"name":"Nakamura Y"},{"name":"Momoxawa Y"},{"name":"Kubo M"},{"name":"Nakatochi M"},{"name":"Naito M"},{"name":"Wakai K"}],"ja":[{"name":"Shimanoe C"},{"name":"Hachiya T"},{"name":"Hara M"},{"name":"Nishida Y"},{"name":"Tanaka K"},{"name":"Sutoh Y"},{"name":"Shimizu A"},{"name":"Hishida R"},{"name":"Kawai S"},{"name":"Okada R"},{"name":"Tamura T"},{"name":"Matsuo K"},{"name":"Ito H"},{"name":"Ozaki E"},{"name":"Matsui D"},{"name":"Ibuseki R"},{"name":"Shimoshikiryo I"},{"name":"Takashima N"},{"name":"Kadota A"},{"name":"有澤 孝吉"},{"name":"上村 浩一"},{"name":"Suzuki S"},{"name":"Watanabe M"},{"name":"Kuriki K"},{"name":"Endoh K"},{"name":"Mikami H"},{"name":"Nakamura Y"},{"name":"Momoxawa Y"},{"name":"Kubo M"},{"name":"Nakatochi M"},{"name":"Naito M"},{"name":"Wakai K"}]},"publication_date":"2018-04-17","publication_name":{"en":"Genes, Brain, and Behavior","ja":"Genes, Brain, and Behavior"},"starting_page":"e12481","ending_page":"e12481","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1111/gbb.12481"],"issn":["1601-183X"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/110919","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/29151477","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=323880","label":"url"}],"paper_title":{"en":"Nutrient-derived dietary patterns and their association with metabolic syndrome in a Japanese population","ja":"Nutrient-derived dietary patterns and their association with metabolic syndrome in a Japanese population"},"authors":{"en":[{"name":"Bahari Tirani"},{"name":"Uemura Hirokazu"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Yamaguchi Miwa"},{"name":"Nakamoto Mariko"},{"name":"Miki Keisuke"},{"name":"Ishizu Masashi"},{"name":"Arisawa Kokichi"}],"ja":[{"name":"Tirani Bahari"},{"name":"上村 浩一"},{"name":"勝浦-釜野 桜子"},{"name":"Yamaguchi Miwa"},{"name":"中本 真理子"},{"name":"三木 啓輔"},{"name":"石津 将"},{"name":"有澤 孝吉"}]},"description":{"en":"Nutrients have been proposed to be related to metabolic syndrome (MetS). The aims of this study were to identify dietary patterns that correlated with several nutrients using reduced rank regression (RRR) and to examine the association between extracted dietary patterns and prevalence of MetS in a Japanese population. The study population comprised 1,092 Japanese men and women (35-69 years old) who had participated in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study in Tokushima Prefecture. Dietary patterns were derived with RRR using 46 food items as predictors and six established nutrients (potassium, calcium, vitamin D, vitamin C, insoluble dietary fiber, and carotene) as response variables. Associations between extracted dietary patterns and MetS were then examined with logistic regression models. Among the six dietary patterns, dietary pattern 1 (DP1) explained the largest proportion (60.1%) of variance in the six nutrients. Therefore, only DP1 was selected for further analysis. DP1 was characterized by high intake frequency of vegetables, fruits, fish and small fish, natto (fermented soybeans), and deep-fried tofu. After adjustment for potential confounders, significant inverse associations were found between DP1 score and MetS (odds ratio [OR] for each quartile: 1.00, 0.58, 0.60, 0.52; P = 0.02); DP1 and high blood pressure (P = 0.0002); and DP1 and high blood glucose (P = 0.02). A dietary pattern characterized by high intake of vegetables, fruits, fish and small fish, natto, and deep-fried tofu was associated with reduced prevalence of MetS in a Japanese population.","ja":"Nutrients have been proposed to be related to metabolic syndrome (MetS). The aims of this study were to identify dietary patterns that correlated with several nutrients using reduced rank regression (RRR) and to examine the association between extracted dietary patterns and prevalence of MetS in a Japanese population. The study population comprised 1,092 Japanese men and women (35-69 years old) who had participated in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study in Tokushima Prefecture. Dietary patterns were derived with RRR using 46 food items as predictors and six established nutrients (potassium, calcium, vitamin D, vitamin C, insoluble dietary fiber, and carotene) as response variables. Associations between extracted dietary patterns and MetS were then examined with logistic regression models. Among the six dietary patterns, dietary pattern 1 (DP1) explained the largest proportion (60.1%) of variance in the six nutrients. Therefore, only DP1 was selected for further analysis. DP1 was characterized by high intake frequency of vegetables, fruits, fish and small fish, natto (fermented soybeans), and deep-fried tofu. After adjustment for potential confounders, significant inverse associations were found between DP1 score and MetS (odds ratio [OR] for each quartile: 1.00, 0.58, 0.60, 0.52; P = 0.02); DP1 and high blood pressure (P = 0.0002); and DP1 and high blood glucose (P = 0.02). A dietary pattern characterized by high intake of vegetables, fruits, fish and small fish, natto, and deep-fried tofu was associated with reduced prevalence of MetS in a Japanese population."},"publication_date":"2018-04","publication_name":{"en":"Journal of Epidemiology","ja":"Journal of Epidemiology"},"volume":"Vol.28","number":"No.4","starting_page":"194","ending_page":"201","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2188/jea.JE20170010"],"issn":["1349-9092"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/112437","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/29367735","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=339856","label":"url"}],"paper_title":{"en":"A genome-wide association study in the Japanese population idetifies the 12q24 locus for habitual coffee consumption: the J-MICC Study","ja":"A genome-wide association study in the Japanese population idetifies the 12q24 locus for habitual coffee consumption: the J-MICC Study"},"authors":{"en":[{"name":"Nakagawa-Senda H"},{"name":"Hachiya T"},{"name":"Shimizu A"},{"name":"Hosono S"},{"name":"Oze I"},{"name":"Watanabe M"},{"name":"Matsuo K"},{"name":"Ito M"},{"name":"Hara M"},{"name":"Nishida Y"},{"name":"Endoh K"},{"name":"Kuriki K"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Arisawa Kokichi"},{"name":"Nindita Y"},{"name":"Ibusuki R"},{"name":"Suzuki S"},{"name":"Hosono A"},{"name":"Mikami H"},{"name":"Nakamura Y"},{"name":"Takashima N"},{"name":"Nakamura Y"},{"name":"Kuriyama N"},{"name":"Ozaki E"},{"name":"Furusyo N"},{"name":"Ikezaki H"},{"name":"Nakatochi N"},{"name":"Sasakabe N"},{"name":"Kawai S"},{"name":"Okada R"},{"name":"Hishida A"},{"name":"Naito M"},{"name":"Wakai K"},{"name":"Momozawa Y"},{"name":"Kubo M"},{"name":"Tanaka K"}],"ja":[{"name":"Nakagawa-Senda H"},{"name":"Hachiya T"},{"name":"Shimizu A"},{"name":"Hosono S"},{"name":"Oze I"},{"name":"Watanabe M"},{"name":"Matsuo K"},{"name":"Ito M"},{"name":"Hara M"},{"name":"Nishida Y"},{"name":"Endoh K"},{"name":"Kuriki K"},{"name":"勝浦-釜野 桜子"},{"name":"有澤 孝吉"},{"name":"Nindita Y"},{"name":"Ibusuki R"},{"name":"Suzuki S"},{"name":"Hosono A"},{"name":"Mikami H"},{"name":"Nakamura Y"},{"name":"Takashima N"},{"name":"Nakamura Y"},{"name":"Kuriyama N"},{"name":"Ozaki E"},{"name":"Furusyo N"},{"name":"Ikezaki H"},{"name":"Nakatochi N"},{"name":"Sasakabe N"},{"name":"Kawai S"},{"name":"Okada R"},{"name":"Hishida A"},{"name":"Naito M"},{"name":"Wakai K"},{"name":"Momozawa Y"},{"name":"Kubo M"},{"name":"Tanaka K"}]},"description":{"en":"Coffee is one of the most widely consumed beverages worldwide, and its role in human health has received much attention. Although genome-wide association studies (GWASs) have investigated genetic variants associated with coffee consumption in European populations, no such study has yet been conducted in an Asian population. Here, we conducted a GWAS to identify common genetic variations that affected coffee consumption in a Japanese population of 11,261 participants recruited as a part of the Japan Multi-Institutional Collaborative Cohort (J-MICC) study. Coffee consumption was collected using a self-administered questionnaire, and converted from categories to cups/day. In the discovery stage (n = 6,312), we found 2 independent loci (12q24.12-13 and 5q33.3) that met suggestive significance (P < 1 × 10). In the replication stage (n = 4,949), the lead variant for the 12q24.12-13 locus (rs2074356) was significantly associated with habitual coffee consumption (P = 2.2 × 10), whereas the lead variant for the 5q33.3 locus (rs1957553) was not (P = 0.53). A meta-analysis of the discovery and replication populations, and the combined analysis using all subjects, revealed that rs2074356 achieved genome-wide significance (P = 2.2 × 10 for a meta-analysis). These findings indicate that the 12q24.12-13 locus is associated with coffee consumption among a Japanese population.","ja":"Coffee is one of the most widely consumed beverages worldwide, and its role in human health has received much attention. Although genome-wide association studies (GWASs) have investigated genetic variants associated with coffee consumption in European populations, no such study has yet been conducted in an Asian population. Here, we conducted a GWAS to identify common genetic variations that affected coffee consumption in a Japanese population of 11,261 participants recruited as a part of the Japan Multi-Institutional Collaborative Cohort (J-MICC) study. Coffee consumption was collected using a self-administered questionnaire, and converted from categories to cups/day. In the discovery stage (n = 6,312), we found 2 independent loci (12q24.12-13 and 5q33.3) that met suggestive significance (P < 1 × 10). In the replication stage (n = 4,949), the lead variant for the 12q24.12-13 locus (rs2074356) was significantly associated with habitual coffee consumption (P = 2.2 × 10), whereas the lead variant for the 5q33.3 locus (rs1957553) was not (P = 0.53). A meta-analysis of the discovery and replication populations, and the combined analysis using all subjects, revealed that rs2074356 achieved genome-wide significance (P = 2.2 × 10 for a meta-analysis). These findings indicate that the 12q24.12-13 locus is associated with coffee consumption among a Japanese population."},"publication_date":"2018-01-24","publication_name":{"en":"Scientific Reports","ja":"Scientific Reports"},"volume":"Vol.8","number":"No.1","starting_page":"1493","ending_page":"1493","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1038/s41598-018-19914-w"],"issn":["2045-2322"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/111900","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/29371759","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1390282679650033664/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=330347","label":"url"}],"paper_title":{"en":"Dietary calcium intake is associated with serum high-sensitivity C-reactive protein level in the general Japanese population","ja":"Dietary calcium intake is associated with serum high-sensitivity C-reactive protein level in the general Japanese population"},"authors":{"en":[{"name":"Katsuura-Kamano Sakurako"},{"name":"Uemura Hirokazu"},{"name":"Yamaguchi Miwa"},{"name":"Nakamoto Mariko"},{"name":"Bahari Tirani"},{"name":"Miki Keisuke"},{"name":"Ishizu Masashi"},{"name":"Sawachika Fusakazu"},{"name":"Arisawa Kokichi"}],"ja":[{"name":"勝浦-釜野 桜子"},{"name":"上村 浩一"},{"name":"山口 美輪"},{"name":"中本 真理子"},{"name":"Tirani Bahari"},{"name":"三木 啓輔"},{"name":"石津 将"},{"name":"澤近 房和"},{"name":"有澤 孝吉"}]},"description":{"en":"The beneficial effects of dietary calcium intake on high-sensitivity C-reactive protein levels, a risk factor of cardiovascular disease, have not been fully elucidated. This study investigated the associations between dietary calcium intake and serum high-sensitivity C-reactive protein levels in the general Japanese population. We analyzed the data of 2,019 subjects (1,194 men and 825 women) aged 35 to 69 years in a cross-sectional study of the Japan Multi-Institutional Collaborative Cohort Study. Nutrients intake including calcium were estimated using a validated food-frequency questionnaire. Analysis using a general linear model revealed that dietary calcium intake was inversely associated with serum high-sensitivity C-reactive protein levels ( for trend <0.001) after adjustment for age, sex, research group, leisure-time physical activity, smoking habit, drinking habit, dietary intakes (energy, dietary fiber, saturated fatty acids and vitamin D) and menopausal status. The association was slightly attenuated after additional adjustment for body mass index; however, remained significant ( for trend = 0.008). There were no significant interactions between dietary calcium intakes and sex, body mass index, or vitamin D intake for high-sensitivity C-reactive protein levels. This study have demonstrated that dietary calcium intake was inversely associated with serum high-sensitivity C-reactive protein levels in the general population.","ja":"The beneficial effects of dietary calcium intake on high-sensitivity C-reactive protein levels, a risk factor of cardiovascular disease, have not been fully elucidated. This study investigated the associations between dietary calcium intake and serum high-sensitivity C-reactive protein levels in the general Japanese population. We analyzed the data of 2,019 subjects (1,194 men and 825 women) aged 35 to 69 years in a cross-sectional study of the Japan Multi-Institutional Collaborative Cohort Study. Nutrients intake including calcium were estimated using a validated food-frequency questionnaire. Analysis using a general linear model revealed that dietary calcium intake was inversely associated with serum high-sensitivity C-reactive protein levels ( for trend <0.001) after adjustment for age, sex, research group, leisure-time physical activity, smoking habit, drinking habit, dietary intakes (energy, dietary fiber, saturated fatty acids and vitamin D) and menopausal status. The association was slightly attenuated after additional adjustment for body mass index; however, remained significant ( for trend = 0.008). There were no significant interactions between dietary calcium intakes and sex, body mass index, or vitamin D intake for high-sensitivity C-reactive protein levels. This study have demonstrated that dietary calcium intake was inversely associated with serum high-sensitivity C-reactive protein levels in the general population."},"publication_date":"2018-01","publication_name":{"en":"Journal of Clinical Biochemistry and Nutrition","ja":"Journal of Clinical Biochemistry and Nutrition"},"volume":"Vol.62","number":"No.1","starting_page":"89","ending_page":"93","languages":["eng"],"referee":true,"identifiers":{"doi":["10.3164/jcbn.17-48"],"issn":["0912-0009"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/111414","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/29593198","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1390282679224674560/","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85044467994&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=337836","label":"url"}],"paper_title":{"en":"Associations between intake of dietary fermented soy food and concentrations of inflammatory markers: a cross-sectional study in Japanese workers","ja":"Associations between intake of dietary fermented soy food and concentrations of inflammatory markers: a cross-sectional study in Japanese workers"},"authors":{"en":[{"name":"Xiaolin Yang"},{"name":"Nakamoto Mariko"},{"name":"Shuto Emi"},{"name":"Hata Akiko"},{"name":"Nanako Aki"},{"name":"Shikama Yosuke"},{"name":"Bandou Yukiko"},{"name":"Ichihara Takako"},{"name":"Minagawa Takako"},{"name":"Kuwamura Yumi"},{"name":"Tamura Ayako"},{"name":"Uemura Hirokazu"},{"name":"Arisawa Kokichi"},{"name":"Funaki Makoto"},{"name":"Sakai Tohru"}],"ja":[{"name":"楊 琳"},{"name":"中本 真理子"},{"name":"首藤 恵泉"},{"name":"秦 明子"},{"name":"Nanako Aki"},{"name":"四釜 洋介"},{"name":"坂東 由記子"},{"name":"市原 多香子"},{"name":"南川 貴子"},{"name":"桑村 由美"},{"name":"田村 綾子"},{"name":"上村 浩一"},{"name":"有澤 孝吉"},{"name":"船木 真理"},{"name":"酒井 徹"}]},"description":{"en":"Epidemiological investigations have shown that consumption of soybeans or soy foods reduces the risk of the development of cardiovascular disease, cancer and osteoporosis. The aim of this study was to determine the associations between different soy foods and inflammatory markers, including high-sensitivity C-reactive protein (hs-CRP), interleukin (IL)-6, and IL-18, in Japanese workers. The cross-sectional study included 1,426 Japanese workers (1,053 men and 373 women) aged 20 to 64 years. Intake of 12 soy foods was estimated by a validated food frequency questionnaire. Associations of total soy foods, fermented soy food, non-fermented soy food, soy isoflavone with hs-CRP, IL-6, and IL-18 levels were examined by general linear model regression analysis. We found that total fermented soy food intake was inversely associated with multivariable-adjusted geometric concentration of IL-6 in men (Q1:1.03 pg/mL, Q5:0.94 pg /mL;P for trend = 0.031). Furthermore, it was shown that IL-6 concentrations were inversely associated with miso intake (β = -0.068;p = 0.034) and soy sauce intake in men (β = -0.074;p = 0.018). This study suggests that intake of total fermented soy food, miso and soy sauce be associated with IL-6 concentrations in Japanese men. J. Med. Invest. 65:74-80, February, 2018.","ja":"Epidemiological investigations have shown that consumption of soybeans or soy foods reduces the risk of the development of cardiovascular disease, cancer and osteoporosis. The aim of this study was to determine the associations between different soy foods and inflammatory markers, including high-sensitivity C-reactive protein (hs-CRP), interleukin (IL)-6, and IL-18, in Japanese workers. The cross-sectional study included 1,426 Japanese workers (1,053 men and 373 women) aged 20 to 64 years. Intake of 12 soy foods was estimated by a validated food frequency questionnaire. Associations of total soy foods, fermented soy food, non-fermented soy food, soy isoflavone with hs-CRP, IL-6, and IL-18 levels were examined by general linear model regression analysis. We found that total fermented soy food intake was inversely associated with multivariable-adjusted geometric concentration of IL-6 in men (Q1:1.03 pg/mL, Q5:0.94 pg /mL;P for trend = 0.031). Furthermore, it was shown that IL-6 concentrations were inversely associated with miso intake (β = -0.068;p = 0.034) and soy sauce intake in men (β = -0.074;p = 0.018). This study suggests that intake of total fermented soy food, miso and soy sauce be associated with IL-6 concentrations in Japanese men. J. Med. Invest. 65:74-80, February, 2018."},"publication_date":"2018","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.65","number":"No.1-2","starting_page":"74","ending_page":"80","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.65.74"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/29086206","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=334531","label":"url"}],"paper_title":{"en":"Radiotherapy for vaginal cancer: a multi-institutional survey study of the Japanese Radiation Oncology Study Group","ja":"Radiotherapy for vaginal cancer: a multi-institutional survey study of the Japanese Radiation Oncology Study Group"},"authors":{"en":[{"name":"Ikushima Hitoshi"},{"name":"Masaru Wakatsuki"},{"name":"Takuro Ariga"},{"name":"Yuko Kaneyasu"},{"name":"Sunao Tokumaru"},{"name":"Fumiaki Isohashi"},{"name":"Noriko Ii"},{"name":"Takashi Uno"},{"name":"Yatsuya Ohno"},{"name":"Arisawa Kokichi"},{"name":"Takafumi Toita"}],"ja":[{"name":"生島 仁史"},{"name":"Masaru Wakatsuki"},{"name":"Takuro Ariga"},{"name":"Yuko Kaneyasu"},{"name":"Sunao Tokumaru"},{"name":"Fumiaki Isohashi"},{"name":"Noriko Ii"},{"name":"Takashi Uno"},{"name":"Yatsuya Ohno"},{"name":"有澤 孝吉"},{"name":"Takafumi Toita"}]},"description":{"en":"Our aim was to assess the patterns of practice and treatment outcomes of definitive radiotherapy (RT) for vaginal cancer in Japan. RT methods and outcomes of patients with vaginal cancer treated with definitive RT or chemoradiotherapy at 10 institutes of the Japanese Radiation Oncology Study Group between January 2000 and March 2010 were retrospectively evaluated. A total of 90 patients were enrolled in the study. The clinical stages were I, II, III, and IVA in 34, 36, 16, and 4 patients, respectively. Seventy patients were treated with three-dimensional conformal RT (3DCRT) and brachytherapy (BT), 12 with BT alone, and 8 with 3DCRT alone. Chemotherapy was administered to 29 patients. The 5-year overall survival and local control rates were 77 and 83% with a median follow-up period of 94 months for surviving or lost patients. The 5-year overall survival rates according to stage were 94, 71, 56, and 75% for stages I, II, III, and IVA, respectively. The 5-year local control rates according to stage were 94, 77, 74, and 75% for stages I, II, III, and IVA, respectively. Twenty-nine percent (6 of 21 patients) of local recurrences occurred between 5 and 10 years after RT. The 10-year local control rate of all patients was 71%. Significant prognostic factors for overall survival by univariate and multi-variate analyses were performance status, tumor size, and pelvic lymph node metastasis. Grade 3 late radiation morbidity of the rectum, pelvic bone, urinary bladder, and skin developed in 9% (8 of 90 patients). Good outcomes similar to those of cervical cancer can be achieved with definitive RT delivered by 3DCRT and/or BT for vaginal cancer. Long follow-up is necessary for a continuing risk of local recurrence after 5 years.","ja":"Our aim was to assess the patterns of practice and treatment outcomes of definitive radiotherapy (RT) for vaginal cancer in Japan. RT methods and outcomes of patients with vaginal cancer treated with definitive RT or chemoradiotherapy at 10 institutes of the Japanese Radiation Oncology Study Group between January 2000 and March 2010 were retrospectively evaluated. A total of 90 patients were enrolled in the study. The clinical stages were I, II, III, and IVA in 34, 36, 16, and 4 patients, respectively. Seventy patients were treated with three-dimensional conformal RT (3DCRT) and brachytherapy (BT), 12 with BT alone, and 8 with 3DCRT alone. Chemotherapy was administered to 29 patients. The 5-year overall survival and local control rates were 77 and 83% with a median follow-up period of 94 months for surviving or lost patients. The 5-year overall survival rates according to stage were 94, 71, 56, and 75% for stages I, II, III, and IVA, respectively. The 5-year local control rates according to stage were 94, 77, 74, and 75% for stages I, II, III, and IVA, respectively. Twenty-nine percent (6 of 21 patients) of local recurrences occurred between 5 and 10 years after RT. The 10-year local control rate of all patients was 71%. Significant prognostic factors for overall survival by univariate and multi-variate analyses were performance status, tumor size, and pelvic lymph node metastasis. Grade 3 late radiation morbidity of the rectum, pelvic bone, urinary bladder, and skin developed in 9% (8 of 90 patients). Good outcomes similar to those of cervical cancer can be achieved with definitive RT delivered by 3DCRT and/or BT for vaginal cancer. Long follow-up is necessary for a continuing risk of local recurrence after 5 years."},"publication_date":"2017-10-30","publication_name":{"en":"International Journal of Clinical Oncology","ja":"International Journal of Clinical Oncology"},"starting_page":"1","ending_page":"7","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s10147-017-1205-z"],"issn":["1437-7772"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/111912","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/28637371","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=324759","label":"url"}],"paper_title":{"en":"Association between Dietary Patterns and Serum Adiponectin: A Cross-Sectional Study in a Japanese Population","ja":"Association between Dietary Patterns and Serum Adiponectin: A Cross-Sectional Study in a Japanese Population"},"authors":{"en":[{"name":"Bahari Tirani"},{"name":"Uemura Hirokazu"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Yamaguchi Miwa"},{"name":"Nakamoto Mariko"},{"name":"Miki Keisuke"},{"name":"Sawachika Fusakazu"},{"name":"Arisawa Kokichi"}],"ja":[{"name":"Bahari Tirani"},{"name":"上村 浩一"},{"name":"勝浦-釜野 桜子"},{"name":"Yamaguchi Miwa"},{"name":"中本 真理子"},{"name":"Miki Keisuke"},{"name":"Sawachika Fusakazu"},{"name":"有澤 孝吉"}]},"description":{"en":"The aim of this study was to evaluate the associations between dietary pattern, adiponectin and insulin resistance. The study population consisted of 612 men and women aged 35-69 years old who had participated in the baseline survey of Japan Multi-Institutional Collaborative Cohort (J-MICC) Study in Tokushima Prefecture. Diets and lifestyle related variables were assessed by questionnaires. Multiple regression analyses were used to analyse the relations between dietary patterns and high molecular weight (HMW) adiponectin. For further analysis, path analysis was used to test the hypothesised model of association between dietary pattern, serum adiponectin and insulin resistance. The result showed that higher score of bread and dairy pattern was directly associated with increased serum level of adiponectin in women, which was inversely related to homeostasis model assessment of insulin resistance (HOMA-IR). In conclusion, higher consumption of bread and dairy products, and low intake of rice may be associated with increased serum adiponectin in women.","ja":"The aim of this study was to evaluate the associations between dietary pattern, adiponectin and insulin resistance. The study population consisted of 612 men and women aged 35-69 years old who had participated in the baseline survey of Japan Multi-Institutional Collaborative Cohort (J-MICC) Study in Tokushima Prefecture. Diets and lifestyle related variables were assessed by questionnaires. Multiple regression analyses were used to analyse the relations between dietary patterns and high molecular weight (HMW) adiponectin. For further analysis, path analysis was used to test the hypothesised model of association between dietary pattern, serum adiponectin and insulin resistance. The result showed that higher score of bread and dairy pattern was directly associated with increased serum level of adiponectin in women, which was inversely related to homeostasis model assessment of insulin resistance (HOMA-IR). In conclusion, higher consumption of bread and dairy products, and low intake of rice may be associated with increased serum adiponectin in women."},"publication_date":"2017-06-21","publication_name":{"en":"International Journal of Food Sciences and Nutrition","ja":"International Journal of Food Sciences and Nutrition"},"starting_page":"1","ending_page":"10","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1080/09637486.2017.1338249"],"issn":["1465-3478"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/112329","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/28575103","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=326398","label":"url"}],"paper_title":{"en":"Relationships of serum high-sensitivity C-reactive protein and body size with insulin resistance in a Japanese cohort.","ja":"Relationships of serum high-sensitivity C-reactive protein and body size with insulin resistance in a Japanese cohort."},"authors":{"en":[{"name":"Uemura Hirokazu"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Yamaguchi Miwa"},{"name":"Bahari Tirani"},{"name":"Ishizu Masashi"},{"name":"Fujioka Miho"},{"name":"Arisawa Kokichi"}],"ja":[{"name":"上村 浩一"},{"name":"勝浦-釜野 桜子"},{"name":"Yamaguchi Miwa"},{"name":"Tirani Bahari"},{"name":"石津 将"},{"name":"藤岡 美穂"},{"name":"有澤 孝吉"}]},"description":{"en":"Impacts of chronic systemic inflammation and body size and their interaction effect on insulin resistance in Asian populations, in whom obesity is less common, are not fully understood. This study evaluated combined relationships of systemic inflammation and body size with insulin resistance in a Japanese cohort. We analyzed cross-sectional data from 1,074 eligible subjects (536 men and 538 women) aged 35-69 years who participated in the baseline survey of a cohort study in Tokushima Prefecture, Japan. Systemic inflammation level was assessed by serum high-sensitivity C-reactive protein (hs-CRP), and the degree of insulin resistance and beta-cell function were evaluated by the homeostasis model assessment insulin resistance (HOMA-IR) and beta-cell function (HOMA- ), respectively. Overweight and obesity were defined as a body mass index (BMI) of 23.0-24.9 kg/m2 and ·25.0 kg/m2, respectively. Associations between serum hs-CRP (assessed as quartiles and additionally continuous values after log-transformation) and indices of glucose homeostasis were analysed adjusting for probable covariates, including BMI (quartiles). Combined associations of serum hs-CRP ( median, >median) and body size (normal, overweight, obese) with insulin resistance as well as their interaction effect on insulin resistance were also evaluated. Serum hs-CRP was dose-dependently associated with HOMA-IR, but not HOMA- , after adjustment for probable covariates, including BMI. Subjects with obesity and elevated serum hs-CRP (>median) showed a high multivariable-adjusted HOMA-IR value of 1.32 (95% confidence interval (CI) 1.23, 1.41) compared with subjects with normal BMI and low serum hs-CRP ( median) whose multivariable-adjusted HOMA-IR value was 1.14 (95% CI 1.06, 1.21). The interaction effect between body size (normal, overweight, obese) and serum hs-CRP ( median, >median) on HOMA-IR was significant (P for interaction <0.001). Our study suggests that elevated systemic inflammation is dose-dependently associated with increased insulin resistance, independent of the known risk factors, in a Japanese population. Concomitant obesity and elevated systemic inflammation may synergistically contribute to increased insulin resistance.","ja":"Impacts of chronic systemic inflammation and body size and their interaction effect on insulin resistance in Asian populations, in whom obesity is less common, are not fully understood. This study evaluated combined relationships of systemic inflammation and body size with insulin resistance in a Japanese cohort. We analyzed cross-sectional data from 1,074 eligible subjects (536 men and 538 women) aged 35-69 years who participated in the baseline survey of a cohort study in Tokushima Prefecture, Japan. Systemic inflammation level was assessed by serum high-sensitivity C-reactive protein (hs-CRP), and the degree of insulin resistance and beta-cell function were evaluated by the homeostasis model assessment insulin resistance (HOMA-IR) and beta-cell function (HOMA- ), respectively. Overweight and obesity were defined as a body mass index (BMI) of 23.0-24.9 kg/m2 and ·25.0 kg/m2, respectively. Associations between serum hs-CRP (assessed as quartiles and additionally continuous values after log-transformation) and indices of glucose homeostasis were analysed adjusting for probable covariates, including BMI (quartiles). Combined associations of serum hs-CRP ( median, >median) and body size (normal, overweight, obese) with insulin resistance as well as their interaction effect on insulin resistance were also evaluated. Serum hs-CRP was dose-dependently associated with HOMA-IR, but not HOMA- , after adjustment for probable covariates, including BMI. Subjects with obesity and elevated serum hs-CRP (>median) showed a high multivariable-adjusted HOMA-IR value of 1.32 (95% confidence interval (CI) 1.23, 1.41) compared with subjects with normal BMI and low serum hs-CRP ( median) whose multivariable-adjusted HOMA-IR value was 1.14 (95% CI 1.06, 1.21). The interaction effect between body size (normal, overweight, obese) and serum hs-CRP ( median, >median) on HOMA-IR was significant (P for interaction <0.001). Our study suggests that elevated systemic inflammation is dose-dependently associated with increased insulin resistance, independent of the known risk factors, in a Japanese population. Concomitant obesity and elevated systemic inflammation may synergistically contribute to increased insulin resistance."},"publication_date":"2017-06-02","publication_name":{"en":"PLoS ONE","ja":"PLoS ONE"},"volume":"Vol.12","number":"No.6","starting_page":"e0178672","ending_page":"e0178672","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1371/journal.pone.0178672"],"issn":["1932-6203"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/111894","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/28277893","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=324048","label":"url"}],"paper_title":{"en":"Risk factors for shoulder and elbow pain in youth baseball players.","ja":"Risk factors for shoulder and elbow pain in youth baseball players."},"authors":{"en":[{"name":"Matsuura Tetsuya"},{"name":"Iwame Toshiyuki"},{"name":"Suzue Naoto"},{"name":"Arisawa Kokichi"},{"name":"Sairyo Koichi"}],"ja":[{"name":"松浦 哲也"},{"name":"岩目 敏幸"},{"name":"鈴江 直人"},{"name":"有澤 孝吉"},{"name":"西良 浩一"}]},"description":{"en":"This study sought to quantify the 1-year cumulative incidence of shoulder and elbow pain among youth baseball players and identify risk factors associated with the occurrence of shoulder and elbow pain. In total, 900 youth baseball players (aged 7-11 years) were enrolled in a 1-year prospective follow-up study. One year later, the players were asked whether they had experienced episodes of shoulder or elbow pain and the following risk factors for such pain were investigated: age, position, length of baseball experience, training hours per week, and history of shoulder or elbow pain. Data for the groups with and without shoulder or elbow pain were analyzed using multivariate logistic regression models. Episodes of shoulder pain were reported by 18.3% of players and episodes of elbow pain were reported by 35.2% of players. Multivariate analysis showed that shoulder pain was associated with pitcher position, catcher position, longer training hours per week, and history of shoulder and elbow pain, and that elbow pain was associated with age, pitcher position, catcher position, longer training hours per week, and history of elbow pain. Length of baseball experience was not associated with shoulder or elbow pain. History of elbow pain, pitcher position, catcher position, and longer training hours per week were associated with both types of pain. History of shoulder pain was associated with shoulder pain but not elbow pain. Age was associated with elbow pain but not shoulder pain.","ja":"This study sought to quantify the 1-year cumulative incidence of shoulder and elbow pain among youth baseball players and identify risk factors associated with the occurrence of shoulder and elbow pain. In total, 900 youth baseball players (aged 7-11 years) were enrolled in a 1-year prospective follow-up study. One year later, the players were asked whether they had experienced episodes of shoulder or elbow pain and the following risk factors for such pain were investigated: age, position, length of baseball experience, training hours per week, and history of shoulder or elbow pain. Data for the groups with and without shoulder or elbow pain were analyzed using multivariate logistic regression models. Episodes of shoulder pain were reported by 18.3% of players and episodes of elbow pain were reported by 35.2% of players. Multivariate analysis showed that shoulder pain was associated with pitcher position, catcher position, longer training hours per week, and history of shoulder and elbow pain, and that elbow pain was associated with age, pitcher position, catcher position, longer training hours per week, and history of elbow pain. Length of baseball experience was not associated with shoulder or elbow pain. History of elbow pain, pitcher position, catcher position, and longer training hours per week were associated with both types of pain. History of shoulder pain was associated with shoulder pain but not elbow pain. Age was associated with elbow pain but not shoulder pain."},"publication_date":"2017-05","publication_name":{"en":"The Physician and Sportsmedicine","ja":"The Physician and Sportsmedicine"},"volume":"Vol.45","number":"No.2","starting_page":"140","ending_page":"144","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1080/00913847.2017.1300505"],"issn":["2326-3660"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/114554","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/29176272","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=323883","label":"url"}],"paper_title":{"en":"Modification of the associations of alcohol intake with serum low-density lipoprotein cholesterol and triglycerides by ALDH2 and ADH1B polymorphisms in Japanese men","ja":"Modification of the associations of alcohol intake with serum low-density lipoprotein cholesterol and triglycerides by ALDH2 and ADH1B polymorphisms in Japanese men"},"authors":{"en":[{"name":"Sasakabe Tae"},{"name":"Wakai Kenji"},{"name":"Kawai Sayo"},{"name":"Hishida Asahi"},{"name":"Naito Mariko"},{"name":"Suzuki Sadao"},{"name":"Nindita Yora"},{"name":"Arisawa Kokichi"},{"name":"Kita Yoshikuni"},{"name":"Hara Megumi"},{"name":"Kuriyama Nagato"},{"name":"Hirata Akie"},{"name":"Mikami Haruo"},{"name":"Oze Isao"},{"name":"Kubo Michiaki"},{"name":"Tanaka Hideo"},{"name":"Hamajima Nobuyuki"}],"ja":[{"name":"Sasakabe Tae"},{"name":"Wakai Kenji"},{"name":"Kawai Sayo"},{"name":"Hishida Asahi"},{"name":"Naito Mariko"},{"name":"Suzuki Sadao"},{"name":"Nindita Yora"},{"name":"有澤 孝吉"},{"name":"Kita Yoshikuni"},{"name":"Hara Megumi"},{"name":"Kuriyama Nagato"},{"name":"Hirata Akie"},{"name":"Mikami Haruo"},{"name":"Oze Isao"},{"name":"Kubo Michiaki"},{"name":"Tanaka Hideo"},{"name":"Hamajima Nobuyuki"}]},"description":{"en":"Although beneficial associations have been reported between moderate alcohol intake and the serum lipid profile, it is unclear whether polymorphisms in alcohol-metabolizing enzymes can modify these associations. Here, we assessed the effects of ADH1B His48Arg (rs1229984), ALDH2 Glu504Lys (rs671), and their combination on these associations. Furthermore, we examined if the findings for ALDH2 could be replicated. We categorized 889 male participants in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study into two groups based on presence or absence of minor allele(s) or four groups based on genotype combinations. We performed regression analyses of serum lipid concentrations on alcohol intake, with multivariable adjustment. The replication study was conducted among 2,562 men in the Shizuoka part of the J-MICC Study. The ALDH2 Glu/Lys or Lys/Lys groups showed significant decreases in serum low-density lipoprotein (LDL) cholesterol with increasing alcohol consumption; the coefficient per intake increase of 10 g/day was -2.49 mg/dL (95% confidence interval [CI], -3.85 to -1.13), and a significant interaction with the polymorphism was confirmed (P for interaction = 0.006). This inverse correlation was more evident among the ADH1B His/His + ALDH2 Glu/Lys or Lys/Lys groups (-3.24 mg/dL, 95% CI, -5.03 to -1.45). Serum triglycerides were positively associated with alcohol consumption in the ADH1B His/His group (P for interaction = 0.020). The stronger association between serum LDL cholesterol and alcohol consumption in the ALDH2 Glu/Lys or Lys/Lys groups was replicated. The ALDH2 Glu504Lys polymorphism can modify the association between alcohol intake and serum LDL cholesterol in Japanese men.","ja":"Although beneficial associations have been reported between moderate alcohol intake and the serum lipid profile, it is unclear whether polymorphisms in alcohol-metabolizing enzymes can modify these associations. Here, we assessed the effects of ADH1B His48Arg (rs1229984), ALDH2 Glu504Lys (rs671), and their combination on these associations. Furthermore, we examined if the findings for ALDH2 could be replicated. We categorized 889 male participants in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study into two groups based on presence or absence of minor allele(s) or four groups based on genotype combinations. We performed regression analyses of serum lipid concentrations on alcohol intake, with multivariable adjustment. The replication study was conducted among 2,562 men in the Shizuoka part of the J-MICC Study. The ALDH2 Glu/Lys or Lys/Lys groups showed significant decreases in serum low-density lipoprotein (LDL) cholesterol with increasing alcohol consumption; the coefficient per intake increase of 10 g/day was -2.49 mg/dL (95% confidence interval [CI], -3.85 to -1.13), and a significant interaction with the polymorphism was confirmed (P for interaction = 0.006). This inverse correlation was more evident among the ADH1B His/His + ALDH2 Glu/Lys or Lys/Lys groups (-3.24 mg/dL, 95% CI, -5.03 to -1.45). Serum triglycerides were positively associated with alcohol consumption in the ADH1B His/His group (P for interaction = 0.020). The stronger association between serum LDL cholesterol and alcohol consumption in the ALDH2 Glu/Lys or Lys/Lys groups was replicated. The ALDH2 Glu504Lys polymorphism can modify the association between alcohol intake and serum LDL cholesterol in Japanese men."},"publication_date":"2017-04-05","publication_name":{"en":"Journal of Epidemiology","ja":"Journal of Epidemiology"},"volume":"Vol.28","number":"No.4","starting_page":"185","ending_page":"193","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2188/jea.JE20160189"],"issn":["1349-9092"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/112349","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/28361994","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=382017","label":"url"}],"paper_title":{"en":"Systemic inflammation and family history in relation to the prevalence of type 2 diabetes based on an alternating decision tree","ja":"Systemic inflammation and family history in relation to the prevalence of type 2 diabetes based on an alternating decision tree"},"authors":{"en":[{"name":"Uemura Hirokazu"},{"name":"GHAIBEH AHMAD AMMAR"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Yamaguchi Miwa"},{"name":"Tirani Bahari"},{"name":"Ishizu Masashi"},{"name":"Moriguchi Hiroki"},{"name":"Arisawa Kokichi"}],"ja":[{"name":"上村 浩一"},{"name":"ガイベ アハマド アンマール"},{"name":"勝浦-釜野 桜子"},{"name":"山口 美輪"},{"name":"Tirani Bahari"},{"name":"石津 将"},{"name":"森口 博基"},{"name":"有澤 孝吉"}]},"description":{"en":"To investigate unknown patterns associated with type 2 diabetes in the Japanese population, we first used an alternating decision tree (ADTree) algorithm, a powerful classification algorithm from data mining, for the data from 1,102 subjects aged 35-69 years. On the basis of the investigated patterns, we then evaluated the associations of serum high-sensitivity C-reactive protein (hs-CRP) as a biomarker of systemic inflammation and family history of diabetes (negative, positive or unknown) with the prevalence of type 2 diabetes because their detailed associations have been scarcely reported. Elevated serum hs-CRP levels were proportionally associated with the increased prevalence of type 2 diabetes after adjusting for probable covariates, including body mass index and family history of diabetes (P for trend = 0.016). Stratified analyses revealed that elevated serum hs-CRP levels were proportionally associated with increased prevalence of diabetes in subjects without a family history of diabetes (P for trend = 0.020) but not in those with a family history or with an unknown family history of diabetes. Our study demonstrates that systemic inflammation was proportionally associated with increased prevalence of type 2 diabetes even after adjusting for body mass index, especially in subjects without a family history of diabetes.","ja":"To investigate unknown patterns associated with type 2 diabetes in the Japanese population, we first used an alternating decision tree (ADTree) algorithm, a powerful classification algorithm from data mining, for the data from 1,102 subjects aged 35-69 years. On the basis of the investigated patterns, we then evaluated the associations of serum high-sensitivity C-reactive protein (hs-CRP) as a biomarker of systemic inflammation and family history of diabetes (negative, positive or unknown) with the prevalence of type 2 diabetes because their detailed associations have been scarcely reported. Elevated serum hs-CRP levels were proportionally associated with the increased prevalence of type 2 diabetes after adjusting for probable covariates, including body mass index and family history of diabetes (P for trend = 0.016). Stratified analyses revealed that elevated serum hs-CRP levels were proportionally associated with increased prevalence of diabetes in subjects without a family history of diabetes (P for trend = 0.020) but not in those with a family history or with an unknown family history of diabetes. Our study demonstrates that systemic inflammation was proportionally associated with increased prevalence of type 2 diabetes even after adjusting for body mass index, especially in subjects without a family history of diabetes."},"publication_date":"2017-03","publication_name":{"en":"Scientific Reports","ja":"Scientific Reports"},"volume":"Vol.7","starting_page":"45502","ending_page":"45502","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1038/srep45502"],"issn":["2045-2322"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/111196","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/27644574","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-84987918312&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=320101","label":"url"}],"paper_title":{"en":"Analysis of the prognostic factors of extensive disease small-cell lung cancer patients in Tokushima University Hospital","ja":"Analysis of the prognostic factors of extensive disease small-cell lung cancer patients in Tokushima University Hospital"},"authors":{"en":[{"name":"Ogino Hirokazu"},{"name":"Hanibuchi Masaki"},{"name":"Kakiuchi Souji"},{"name":"Saijo Atsuro"},{"name":"Tezuka Toshifumi"},{"name":"Toyoda Yuko"},{"name":"Tobiume Makoto"},{"name":"Otsuka Kenji"},{"name":"Sakaguchi Satoshi"},{"name":"Goto Hisatsugu"},{"name":"Arisawa Kokichi"},{"name":"Nishioka Yasuhiko"}],"ja":[{"name":"荻野 広和"},{"name":"埴淵 昌毅"},{"name":"柿内 聡司"},{"name":"西條 敦郎"},{"name":"手塚 敏史"},{"name":"豊田 優子"},{"name":"飛梅 亮"},{"name":"Otsuka Kenji"},{"name":"坂口 暁"},{"name":"後東 久嗣"},{"name":"有澤 孝吉"},{"name":"西岡 安彦"}]},"description":{"en":"Small-cell lung cancer (SCLC) presents aggressive clinical behavior, and its prognosis is still poor. Previously, performance status (PS), or the existence of brain, bone, or liver metastasis were reported to be unfavorable prognostic factors. Given the recent progress of treatment modalities such as radiotherapy techniques and bone modifying agents, the prognostic factors might be different from previous findings. Therefore, we analyzed the prognostic factors of extensive disease SCLC (ED-SCLC) in recent years. ED-SCLC patients treated in Tokushima University Hospital between 2010 and 2016 were analyzed. Log-rank test and the Cox proportional hazards regression model was used in univariate and multivariate analysis, respectively. Totally, 79 patients were analyzed. In the univariate analysis, age, PS, interstitial pneumonia (IP), liver metastasis, pleural dissemination, neutrophil counts, hypoalbuminemia, hypercalcemia and several liver and biliary enzymes were identified as poor prognostic factors. In the multivariate analysis, age, PS, IP, and liver and biliary enzymes were identified. Moreover, the PS in patients with liver metastasis was significantly worsened. In this study, we newly demonstrated that IP was a significant poor prognostic factor of ED-SCLC. Although liver metastasis was not extracted in multivariate analysis, it may have an impact on the prognosis of ED-SCLC. J. Med. Invest. 63: 286-293, August, 2016.","ja":"Small-cell lung cancer (SCLC) presents aggressive clinical behavior, and its prognosis is still poor. Previously, performance status (PS), or the existence of brain, bone, or liver metastasis were reported to be unfavorable prognostic factors. Given the recent progress of treatment modalities such as radiotherapy techniques and bone modifying agents, the prognostic factors might be different from previous findings. Therefore, we analyzed the prognostic factors of extensive disease SCLC (ED-SCLC) in recent years. ED-SCLC patients treated in Tokushima University Hospital between 2010 and 2016 were analyzed. Log-rank test and the Cox proportional hazards regression model was used in univariate and multivariate analysis, respectively. Totally, 79 patients were analyzed. In the univariate analysis, age, PS, interstitial pneumonia (IP), liver metastasis, pleural dissemination, neutrophil counts, hypoalbuminemia, hypercalcemia and several liver and biliary enzymes were identified as poor prognostic factors. In the multivariate analysis, age, PS, IP, and liver and biliary enzymes were identified. Moreover, the PS in patients with liver metastasis was significantly worsened. In this study, we newly demonstrated that IP was a significant poor prognostic factor of ED-SCLC. Although liver metastasis was not extracted in multivariate analysis, it may have an impact on the prognosis of ED-SCLC. J. Med. Invest. 63: 286-293, August, 2016."},"publication_date":"2016-08","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.63","number":"No.3 4","starting_page":"286","ending_page":"293","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.63.286"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/111893","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/26831221","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-84964284130&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=311107","label":"url"}],"paper_title":{"en":"Epidemiology of shoulder and elbow pain in youth baseball players.","ja":"Epidemiology of shoulder and elbow pain in youth baseball players."},"authors":{"en":[{"name":"Matsuura Tetsuya"},{"name":"Suzue Naoto"},{"name":"Iwame Toshiyuki"},{"name":"Arisawa Kokichi"},{"name":"Fukuta Shoji"},{"name":"Sairyo Koichi"}],"ja":[{"name":"松浦 哲也"},{"name":"鈴江 直人"},{"name":"岩目 敏幸"},{"name":"有澤 孝吉"},{"name":"福田 昇司"},{"name":"西良 浩一"}]},"description":{"en":"There are relatively few published epidemiological studies examining the differences in the risk of shoulder and elbow pain in young baseball players. The purpose of this study was to investigate risk factors for shoulder and elbow pain in child and adolescent baseball players.","ja":"In over 1000 baseball players aged 7 to 12 years, 15.9% reported episodes of shoulder pain, while 29.2% reported elbow pain in the throwing arm. The associated risk factors were different for each type of pain. Shoulder pain was associated with increased age while elbow pain was associated with increased age, increased years of baseball experience, and playing catcher."},"publication_date":"2016-02-19","publication_name":{"en":"The Physician and Sportsmedicine","ja":"The Physician and Sportsmedicine"},"volume":"Vol.44","number":"No.2","starting_page":"97","ending_page":"100","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1080/00913847.2016.1149422"],"issn":["2326-3660"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/111150","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/27040050","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-84962163463&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=297909","label":"url"}],"paper_title":{"en":"Changes in foot function, disease activity, and disability after forefoot resection arthroplasty in patients with rheumatoid arthritis","ja":"Changes in foot function, disease activity, and disability after forefoot resection arthroplasty in patients with rheumatoid arthritis"},"authors":{"en":[{"name":"Sawachika Fusakazu"},{"name":"Uemura Hirokazu"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Yamaguchi Miwa"},{"name":"Bahari Tirani"},{"name":"Miki Keisuke"},{"name":"Todo Satoshi"},{"name":"Inoo Masayuki"},{"name":"Onishi Ikuko"},{"name":"Kurata Noriyuki"},{"name":"Arisawa Kokichi"}],"ja":[{"name":"澤近 房和"},{"name":"上村 浩一"},{"name":"勝浦-釜野 桜子"},{"name":"山口 美輪"},{"name":"Tirani Bahari"},{"name":"三木 啓輔"},{"name":"Todo Satoshi"},{"name":"Inoo Masayuki"},{"name":"Onishi Ikuko"},{"name":"Kurata Noriyuki"},{"name":"有澤 孝吉"}]},"description":{"en":"The purpose of this study was to investigate the changes in foot function, disease activity, and disability in patients with RA after resection arthroplasty of the forefoot (arthroplasty). Arthroplasty was performed on 11 patients with RA. All study patients underwent clinical assessment to measure disease activity (Disease Activity Score in 28 Joints-C-reactive protein, DAS28-CRP), disability (Health Assessment Questionnaire-Disability Index, HAQ-DI) and foot function (Foot Function Index, FFI) at the following stages: preoperatively and 1, 3, and 12 months after surgery. Following arthroplasty, foot function improved significantly, as assessed by FFI total and subscales (pain, disability, and limitation of activity) (P<0.001, P<0.001, P<0.001, and P=0.002, respectively). Disease activity was significantly improved in relation to DAS28-CRP and its subscales of number of swollen joints and patient global assessment (PtGA) (P=0.033, P=0.008, and P=0.038, respectively). There was no significant difference in disability, as assessed by the HAQ-DI and its subscale, HAQ-walking (P=0.150 and P=0.597, respectively). Foot function improved significantly after arthroplasty, and was maintained at 12 months postoperatively. Additionally, our study showed that disease activity and its subscale PtGA improved after arthroplasty.","ja":"The purpose of this study was to investigate the changes in foot function, disease activity, and disability in patients with RA after resection arthroplasty of the forefoot (arthroplasty). Arthroplasty was performed on 11 patients with RA. All study patients underwent clinical assessment to measure disease activity (Disease Activity Score in 28 Joints-C-reactive protein, DAS28-CRP), disability (Health Assessment Questionnaire-Disability Index, HAQ-DI) and foot function (Foot Function Index, FFI) at the following stages: preoperatively and 1, 3, and 12 months after surgery. Following arthroplasty, foot function improved significantly, as assessed by FFI total and subscales (pain, disability, and limitation of activity) (P<0.001, P<0.001, P<0.001, and P=0.002, respectively). Disease activity was significantly improved in relation to DAS28-CRP and its subscales of number of swollen joints and patient global assessment (PtGA) (P=0.033, P=0.008, and P=0.038, respectively). There was no significant difference in disability, as assessed by the HAQ-DI and its subscale, HAQ-walking (P=0.150 and P=0.597, respectively). Foot function improved significantly after arthroplasty, and was maintained at 12 months postoperatively. Additionally, our study showed that disease activity and its subscale PtGA improved after arthroplasty."},"publication_date":"2016-02","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.63","number":"No.1,2","starting_page":"38","ending_page":"44","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.63.38"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/114964","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/26567959","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-84947600413&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=306099","label":"url"}],"paper_title":{"en":"The Shigatosin 2 production level in enterohemorrhagic Escherichia coli O157:H7 is correlated with the subtypes of toxin-encoding phage","ja":"The Shigatosin 2 production level in enterohemorrhagic Escherichia coli O157:H7 is correlated with the subtypes of toxin-encoding phage"},"authors":{"en":[{"name":"Ogura Yoshitoshi"},{"name":"Mondal Islam Shakhinur"},{"name":"Islam Rakibul Md"},{"name":"Mako Toshihiro"},{"name":"Arisawa Kokichi"},{"name":"Katsura Keisuke"},{"name":"Ooka Tadasuke"},{"name":"Gotoh Yasuhiro"},{"name":"Murase Kazunori"},{"name":"Ohnishi Makoto"},{"name":"Hayashi Tetsuya"}],"ja":[{"name":"Ogura Yoshitoshi"},{"name":"Mondal Islam Shakhinur"},{"name":"Islam Rakibul Md"},{"name":"Mako Toshihiro"},{"name":"有澤 孝吉"},{"name":"Katsura Keisuke"},{"name":"Ooka Tadasuke"},{"name":"Gotoh Yasuhiro"},{"name":"Murase Kazunori"},{"name":"Ohnishi Makoto"},{"name":"Hayashi Tetsuya"}]},"description":{"en":"Enterohemorrhagic E. coli (EHEC) causes diarrhea and hemorrhagic colitis with life-threatening complications, such as hemolytic uremic syndrome. Their major virulence factor is Shiga toxin (Stx), which is encoded by bacteriophages. Of the two types of Stx, the production of Stx2, particularly that of Stx2a (a subtype of Stx2), is a major risk factor for severe EHEC infections, but the Stx2 production level is highly variable between strains. Here, we define four major and two minor subtypes of Stx2a-encoding phages according to their replication proteins. The subtypes are correlated with Stx2a titers produced by the host O157 strains, suggesting a critical role of the phage subtype in determining the Stx2a production level. We further show that one of the two subclades in the clade 8, a proposed hyper-virulent lineage of O157, carries the Stx2 phage subtype that confers the highest Stx2 production to the host strain. The presence of this subclade may explain the proposed high virulence potential of clade 8. These results provide novel insights into the variation in virulence among O157 strains and highlight the role of phage variation in determining the production level of the virulence factors that phages encode.","ja":"Enterohemorrhagic E. coli (EHEC) causes diarrhea and hemorrhagic colitis with life-threatening complications, such as hemolytic uremic syndrome. Their major virulence factor is Shiga toxin (Stx), which is encoded by bacteriophages. Of the two types of Stx, the production of Stx2, particularly that of Stx2a (a subtype of Stx2), is a major risk factor for severe EHEC infections, but the Stx2 production level is highly variable between strains. Here, we define four major and two minor subtypes of Stx2a-encoding phages according to their replication proteins. The subtypes are correlated with Stx2a titers produced by the host O157 strains, suggesting a critical role of the phage subtype in determining the Stx2a production level. We further show that one of the two subclades in the clade 8, a proposed hyper-virulent lineage of O157, carries the Stx2 phage subtype that confers the highest Stx2 production to the host strain. The presence of this subclade may explain the proposed high virulence potential of clade 8. These results provide novel insights into the variation in virulence among O157 strains and highlight the role of phage variation in determining the production level of the virulence factors that phages encode."},"publication_date":"2015-11-16","publication_name":{"en":"Scientific Reports","ja":"Scientific Reports"},"volume":"Vol.5","starting_page":"16663","ending_page":"16663","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1038/srep16663"],"issn":["2045-2322"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/114965","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/26524967","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-84946600223&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=305285","label":"url"}],"paper_title":{"en":"Genetic variants of SLC17A1 are associated with cholesterol homeostasis and hyperhomocysteinaemia in Japanese men","ja":"Genetic variants of SLC17A1 are associated with cholesterol homeostasis and hyperhomocysteinaemia in Japanese men"},"authors":{"en":[{"name":"Koyama Teruhide"},{"name":"Matsui Daisuke"},{"name":"Kuriyama Nagato"},{"name":"Ozaki Etsuko"},{"name":"Tanaka Keitaro"},{"name":"Oze Isao"},{"name":"Hamajima Nobuyuki"},{"name":"Wakai Kenji"},{"name":"Okada Rieko"},{"name":"Arisawa Kokichi"},{"name":"Mikami Haruo"},{"name":"Shimatani Keiichi"},{"name":"Hirata Akie"},{"name":"Takashima Naoyuki"},{"name":"Suzuki Sadao"},{"name":"Nagata Chisato"},{"name":"Kubo Michiaki"},{"name":"Tanaka Hideo"}],"ja":[{"name":"Koyama Teruhide"},{"name":"Matsui Daisuke"},{"name":"Kuriyama Nagato"},{"name":"Ozaki Etsuko"},{"name":"Tanaka Keitaro"},{"name":"Oze Isao"},{"name":"Hamajima Nobuyuki"},{"name":"Wakai Kenji"},{"name":"Okada Rieko"},{"name":"有澤 孝吉"},{"name":"Mikami Haruo"},{"name":"Shimatani Keiichi"},{"name":"Hirata Akie"},{"name":"Takashima Naoyuki"},{"name":"Suzuki Sadao"},{"name":"Nagata Chisato"},{"name":"Kubo Michiaki"},{"name":"Tanaka Hideo"}]},"description":{"en":"Hyperuricaemia is an undisputed and highly predictive biomarker for cardiovascular risk. SLC17A1, expressed in the liver and kidneys, harbours potent candidate single nucleotide polymorphisms that decrease uric acid levels. Therefore, we examined SLC17A1 polymorphisms (rs1165196, rs1179086, and rs3757131), which might suppress cardiovascular risk factors and that are involved in liver functioning, via a large-scale pooled analysis of the Japanese general population in a cross-sectional study. Using data from the Japan Multi-Institutional Collaborative Cohort Study, we identified 1842 participants of both sexes, 35-69-years-old, having the requisite data, and analysed their SLC17A1 genotypes. In men, logistic regression analyses revealed that minor alleles in SLC17A1 polymorphisms (rs1165196 and rs3757131) were associated with a low-/high-density lipoprotein cholesterol ratio >2.0 (rs1165196: odds ratio [OR], 0.703; 95% confidence interval [CI], 0.536-0.922; rs3757131: OR, 0.658; 95% CI, 0.500-0.866), and with homocysteine levels of >10.0 nmol/mL (rs1165196: OR, 0.544; 95% CI, 0.374-0.792; rs3757131: OR, 0.509; 95% CI, 0.347-0.746). Therefore, these polymorphisms had dominant negative effects on cholesterol homeostasis and hyperhomocysteinaemia, in men, independent of alcohol consumption, physical activity, or daily energy and nutrition intake. Thus, genetic variants of SLC17A1 are potential biomarkers for altered cholesterol homeostasis and hyperhomocysteinaemia in Japanese men.","ja":"Hyperuricaemia is an undisputed and highly predictive biomarker for cardiovascular risk. SLC17A1, expressed in the liver and kidneys, harbours potent candidate single nucleotide polymorphisms that decrease uric acid levels. Therefore, we examined SLC17A1 polymorphisms (rs1165196, rs1179086, and rs3757131), which might suppress cardiovascular risk factors and that are involved in liver functioning, via a large-scale pooled analysis of the Japanese general population in a cross-sectional study. Using data from the Japan Multi-Institutional Collaborative Cohort Study, we identified 1842 participants of both sexes, 35-69-years-old, having the requisite data, and analysed their SLC17A1 genotypes. In men, logistic regression analyses revealed that minor alleles in SLC17A1 polymorphisms (rs1165196 and rs3757131) were associated with a low-/high-density lipoprotein cholesterol ratio >2.0 (rs1165196: odds ratio [OR], 0.703; 95% confidence interval [CI], 0.536-0.922; rs3757131: OR, 0.658; 95% CI, 0.500-0.866), and with homocysteine levels of >10.0 nmol/mL (rs1165196: OR, 0.544; 95% CI, 0.374-0.792; rs3757131: OR, 0.509; 95% CI, 0.347-0.746). Therefore, these polymorphisms had dominant negative effects on cholesterol homeostasis and hyperhomocysteinaemia, in men, independent of alcohol consumption, physical activity, or daily energy and nutrition intake. Thus, genetic variants of SLC17A1 are potential biomarkers for altered cholesterol homeostasis and hyperhomocysteinaemia in Japanese men."},"publication_date":"2015-11-03","publication_name":{"en":"Scientific Reports","ja":"Scientific Reports"},"volume":"Vol.5","starting_page":"15888","ending_page":"15888","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1038/srep15888"],"issn":["2045-2322"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/26497775","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=305164","label":"url"}],"paper_title":{"en":"Association between brain-muscle-ARNT-like protein-2 (BMAL2) gene polymorphism and type 2 diabetes mellitus in obese Japanese individuals: A cross-sectional analysis of the Japan Multi-Institutional Collaborative Cohort Study","ja":"Association between brain-muscle-ARNT-like protein-2 (BMAL2) gene polymorphism and type 2 diabetes mellitus in obese Japanese individuals: A cross-sectional analysis of the Japan Multi-Institutional Collaborative Cohort Study"},"authors":{"en":[{"name":"Yamaguchi Miwa"},{"name":"Uemura Hirokazu"},{"name":"Arisawa Kokichi"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Hamajima Nobuyuki"},{"name":"Hishida Asahi"},{"name":"Suma Shino"},{"name":"Oze Isao"},{"name":"Nakamura Kazuyo"},{"name":"Takashima Naoyuki"},{"name":"Suzuki Sadao"},{"name":"Ibusuki Rie"},{"name":"Mikami Haruo"},{"name":"Ohnaka Keizo"},{"name":"Kuriyama Nagato"},{"name":"Kubo Michiaki"},{"name":"Tanaka Hideo"}],"ja":[{"name":"山口 美輪"},{"name":"上村 浩一"},{"name":"有澤 孝吉"},{"name":"勝浦-釜野 桜子"},{"name":"Hamajima Nobuyuki"},{"name":"Hishida Asahi"},{"name":"Suma Shino"},{"name":"Oze Isao"},{"name":"Nakamura Kazuyo"},{"name":"Takashima Naoyuki"},{"name":"Suzuki Sadao"},{"name":"Ibusuki Rie"},{"name":"Mikami Haruo"},{"name":"Ohnaka Keizo"},{"name":"Kuriyama Nagato"},{"name":"Kubo Michiaki"},{"name":"Tanaka Hideo"}]},"description":{"en":"Brain-muscle-Arnt-like protein-1 (BMAL1) and BMAL2 genes are essential components of the circadian clock, and are considered to be involved in glucose homeostasis. We examined whether single nucleotide polymorphisms (SNPs) of BMAL1 and BMAL2 were associated with the prevalence of type 2 diabetes (T2DM) in the general Japanese population. We studied 2467 subjects (1232 men and 1235 women, 35-69 years old), including 105 men and 57 women with T2DM, from the participants of the Japan Multi-institutional Collaborative Cohort Study. The association between SNPs in the BMAL1 (rs11022775 and rs2290035) and BMAL2 (rs7958822) genes and T2DM were analyzed by multiple logistic regression after adjustment for potential confounders. Analysis was also performed after stratification by body mass index (≥25kg/m(2) and <25kg/m(2)) to investigate an interaction between genotypes and obesity. The A/G and A/A genotypes of BMAL2 rs7958822 showed significantly higher adjusted odds ratios (OR) for T2DM than the G/G genotype among obese men (OR=2.2, 95% confidence intervals [CI] 1.1, 4.6, P for interaction=0.0495) and obese women (OR=2.7, 95% CI 1.1, 6.7, P for interaction=0.199). There were no significant associations between BMAL1 rs11022775 or rs2290035 genotypes and T2DM. To the best of our knowledge, this is the first study to show the significant association between BMAL2 rs7958822 genotype and T2DM among obese subjects.","ja":"Brain-muscle-Arnt-like protein-1 (BMAL1) and BMAL2 genes are essential components of the circadian clock, and are considered to be involved in glucose homeostasis. We examined whether single nucleotide polymorphisms (SNPs) of BMAL1 and BMAL2 were associated with the prevalence of type 2 diabetes (T2DM) in the general Japanese population. We studied 2467 subjects (1232 men and 1235 women, 35-69 years old), including 105 men and 57 women with T2DM, from the participants of the Japan Multi-institutional Collaborative Cohort Study. The association between SNPs in the BMAL1 (rs11022775 and rs2290035) and BMAL2 (rs7958822) genes and T2DM were analyzed by multiple logistic regression after adjustment for potential confounders. Analysis was also performed after stratification by body mass index (≥25kg/m(2) and <25kg/m(2)) to investigate an interaction between genotypes and obesity. The A/G and A/A genotypes of BMAL2 rs7958822 showed significantly higher adjusted odds ratios (OR) for T2DM than the G/G genotype among obese men (OR=2.2, 95% confidence intervals [CI] 1.1, 4.6, P for interaction=0.0495) and obese women (OR=2.7, 95% CI 1.1, 6.7, P for interaction=0.199). There were no significant associations between BMAL1 rs11022775 or rs2290035 genotypes and T2DM. To the best of our knowledge, this is the first study to show the significant association between BMAL2 rs7958822 genotype and T2DM among obese subjects."},"publication_date":"2015-10-25","publication_name":{"en":"Diabetes Research and Clinical Practice","ja":"Diabetes Research and Clinical Practice"},"languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.diabres.2015.10.009"],"issn":["1872-8227"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/26374515","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=307745","label":"url"}],"paper_title":{"en":"A variant of the CLOCK gene and related haplotypes are associated with the prevalence of type 2 diabetes in the Japanese population.","ja":"A variant of the CLOCK gene and related haplotypes are associated with the prevalence of type 2 diabetes in the Japanese population."},"authors":{"en":[{"name":"Uemura Hirokazu"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Yamaguchi Miwa"},{"name":"Arisawa Kokichi"},{"name":"Hamajima Nobuyuki"},{"name":"Hishida Asahi"},{"name":"Kawai Sayo"},{"name":"Oze Isao"},{"name":"Shinchi Koichi"},{"name":"Takashima Naoyuki"},{"name":"Suzuki Sadao"},{"name":"Nakahata Noriko"},{"name":"Mikami Haruo"},{"name":"Ohnaka Keizo"},{"name":"Kuriyama Nagato"},{"name":"Kubo Michiaki"},{"name":"Tanaka Hideo"}],"ja":[{"name":"上村 浩一"},{"name":"勝浦-釜野 桜子"},{"name":"山口 美輪"},{"name":"有澤 孝吉"},{"name":"Hamajima Nobuyuki"},{"name":"Hishida Asahi"},{"name":"Kawai Sayo"},{"name":"Oze Isao"},{"name":"Shinchi Koichi"},{"name":"Takashima Naoyuki"},{"name":"Suzuki Sadao"},{"name":"Nakahata Noriko"},{"name":"Mikami Haruo"},{"name":"Ohnaka Keizo"},{"name":"Kuriyama Nagato"},{"name":"Kubo Michiaki"},{"name":"Tanaka Hideo"}]},"description":{"en":"Circadian rhythm disruption is recognized as the cause of various health disorders. This study evaluated associations between single nucleotide polymorphisms in the core circadian gene, CLOCK, and prevalent type 2 diabetes in the Japanese population. We analyzed cross-sectional data from 2,485 subjects (1,243 men and 1,242 women; age, 35-69 years) who were enrolled in the baseline surveys of the Japan Multi-institutional Collaborative Cohort (J-MICC) Study. Associations between 3 CLOCK gene polymorphisms (rs1801260, rs3736544, and rs4864548) and prevalent obesity (BMI ≥25 kg/m(2) ), overweight (BMI ≥23 kg/m(2) ), and diabetes were evaluated by logistic regression analyses; haplotype analysis and stratified analyses for prevalent diabetes were also conducted. Compared to those who were homozygous for the respective major alleles, subjects with the rs1801260 minor allele C showed a significantly higher odds ratio (95% CI) of 1.5 (1.1-2.1) for prevalent diabetes, after adjustment for potential confounding factors, including BMI. When stratified by overweight, the associations between rs1801260 and prevalent diabetes were marked and significant in non-overweight subjects but were not significant in overweight subjects. The TGA (rs1801260 - rs3736544 - rs4864548) haplotype was associated with lower prevalence of diabetes, and the CGG haplotype was associated with higher prevalence of diabetes. CLOCK gene variants and related haplotypes are associated with prevalent type 2 diabetes in the Japanese population in whom obesity is less common, and the association between a CLOCK gene variants at rs1801260 and prevalent diabetes is enhanced in normal-build subjects.","ja":"Circadian rhythm disruption is recognized as the cause of various health disorders. This study evaluated associations between single nucleotide polymorphisms in the core circadian gene, CLOCK, and prevalent type 2 diabetes in the Japanese population. We analyzed cross-sectional data from 2,485 subjects (1,243 men and 1,242 women; age, 35-69 years) who were enrolled in the baseline surveys of the Japan Multi-institutional Collaborative Cohort (J-MICC) Study. Associations between 3 CLOCK gene polymorphisms (rs1801260, rs3736544, and rs4864548) and prevalent obesity (BMI ≥25 kg/m(2) ), overweight (BMI ≥23 kg/m(2) ), and diabetes were evaluated by logistic regression analyses; haplotype analysis and stratified analyses for prevalent diabetes were also conducted. Compared to those who were homozygous for the respective major alleles, subjects with the rs1801260 minor allele C showed a significantly higher odds ratio (95% CI) of 1.5 (1.1-2.1) for prevalent diabetes, after adjustment for potential confounding factors, including BMI. When stratified by overweight, the associations between rs1801260 and prevalent diabetes were marked and significant in non-overweight subjects but were not significant in overweight subjects. The TGA (rs1801260 - rs3736544 - rs4864548) haplotype was associated with lower prevalence of diabetes, and the CGG haplotype was associated with higher prevalence of diabetes. CLOCK gene variants and related haplotypes are associated with prevalent type 2 diabetes in the Japanese population in whom obesity is less common, and the association between a CLOCK gene variants at rs1801260 and prevalent diabetes is enhanced in normal-build subjects."},"publication_date":"2015-09-16","publication_name":{"en":"Journal of Diabetes","ja":"Journal of Diabetes"},"volume":"Vol.8","number":"No.5","starting_page":"667","ending_page":"676","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1111/1753-0407.12344"],"issn":["1753-0407"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/25382603","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-84936988645&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=286392","label":"url"}],"paper_title":{"en":"Inverse association between soy food consumption and insulin resistance in Japanese adults","ja":"Inverse association between soy food consumption and insulin resistance in Japanese adults"},"authors":{"en":[{"name":"Nakamoto Mariko"},{"name":"Uemura Hirokazu"},{"name":"Sakai Tohru"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Yamaguchi Miwa"},{"name":"Hiyoshi Mineyoshi"},{"name":"Arisawa Kokichi"}],"ja":[{"name":"中本 真理子"},{"name":"上村 浩一"},{"name":"酒井 徹"},{"name":"勝浦-釜野 桜子"},{"name":"山口 美輪"},{"name":"Hiyoshi Mineyoshi"},{"name":"有澤 孝吉"}]},"description":{"en":"The purpose of the present study was to examine the association between soya food consumption and insulin resistance using baseline data of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study in Tokushima, Japan. This cross-sectional study included 1274 subjects, aged 34-70 years at baseline, living in Tokushima Prefecture between 2008 and 2013. Fasting blood samples were collected and information on lifestyle characteristics including soya food intake and medical history were obtained using a structured self-administered questionnaire. The homeostasis model assessment of insulin resistance (HOMA-IR) was measured and those with HOMA-IR ≥ 2.5 were defined as having insulin resistance. Multiple logistic regression models were used to analyse the association between soya product intake and the prevalence of insulin resistance. Rural communities located in Tokushima Prefecture, Japan, between 2008 and 2013. A total of 1148 adults (565 men and 583 women), aged 34-70 years. The frequency of intake of miso soup, total non-fried soya products and total soya products showed significant inverse dose-response relationships with insulin resistance, after adjustments for potential confounders. When soya product intake was calculated as soya protein and isoflavone, the odds ratios of insulin resistance decreased significantly as the estimated intake of soya protein increased. Furthermore, significant inverse dose-response relationships were observed for total non-fried soya products and total soya products, after adjustment for total vegetable or total fibre consumption. The present results indicate that the intake of soya products and non-fried soya products is associated with reduced insulin resistance in the Japanese population.","ja":"The purpose of the present study was to examine the association between soya food consumption and insulin resistance using baseline data of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study in Tokushima, Japan. This cross-sectional study included 1274 subjects, aged 34-70 years at baseline, living in Tokushima Prefecture between 2008 and 2013. Fasting blood samples were collected and information on lifestyle characteristics including soya food intake and medical history were obtained using a structured self-administered questionnaire. The homeostasis model assessment of insulin resistance (HOMA-IR) was measured and those with HOMA-IR ≥ 2.5 were defined as having insulin resistance. Multiple logistic regression models were used to analyse the association between soya product intake and the prevalence of insulin resistance. Rural communities located in Tokushima Prefecture, Japan, between 2008 and 2013. A total of 1148 adults (565 men and 583 women), aged 34-70 years. The frequency of intake of miso soup, total non-fried soya products and total soya products showed significant inverse dose-response relationships with insulin resistance, after adjustments for potential confounders. When soya product intake was calculated as soya protein and isoflavone, the odds ratios of insulin resistance decreased significantly as the estimated intake of soya protein increased. Furthermore, significant inverse dose-response relationships were observed for total non-fried soya products and total soya products, after adjustment for total vegetable or total fibre consumption. The present results indicate that the intake of soya products and non-fried soya products is associated with reduced insulin resistance in the Japanese population."},"publication_date":"2015-08","publication_name":{"en":"Public Health Nutrition","ja":"Public Health Nutrition"},"volume":"Vol.18","number":"No.11","starting_page":"2031","ending_page":"2040","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1017/S136898001400247X"],"issn":["1475-2727"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/25523094","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-84920944244&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=290254","label":"url"}],"paper_title":{"en":"Associations between polymorphisms of interleukin-6 and related cytokine genes and serum liver damage markers: a cross-sectional study in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study","ja":"Associations between polymorphisms of interleukin-6 and related cytokine genes and serum liver damage markers: a cross-sectional study in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study"},"authors":{"en":[{"name":"Sugimoto Y"},{"name":"Wakai K"},{"name":"Nakagawa H"},{"name":"Suma S"},{"name":"Sasakabe T"},{"name":"Sakamoto T"},{"name":"Takashima N"},{"name":"Suzuki S"},{"name":"Ogawa S"},{"name":"Ohnaka K"},{"name":"Kuriyama N"},{"name":"Arisawa Kokichi"},{"name":"Mikami H"},{"name":"Kubo M"},{"name":"Hosono S"},{"name":"Hamajima N"},{"name":"Tanaka H"},{"name":"J-MICC Study Group"}],"ja":[{"name":"Sugimoto Y"},{"name":"Wakai K"},{"name":"Nakagawa H"},{"name":"Suma S"},{"name":"Sasakabe T"},{"name":"Sakamoto T"},{"name":"Takashima N"},{"name":"Suzuki S"},{"name":"Ogawa S"},{"name":"Ohnaka K"},{"name":"Kuriyama N"},{"name":"有澤 孝吉"},{"name":"Mikami H"},{"name":"Kubo M"},{"name":"Hosono S"},{"name":"Hamajima N"},{"name":"Tanaka H"},{"name":"J-MICC Study Group"}]},"description":{"en":"Cytokines, including interleukin-6 (IL-6), play an important role in the liver. The aim of this study was to investigate associations between common polymorphisms in potential functional promoters of cytokine genes and liver damage markers among enrollees of a large Japanese cohort study. Subjects included 3257 Japanese individuals (1608 men and 1649 women, aged 35-69 years). Six single nucleotide polymorphisms (SNPs) in the promoter regions of five cytokine genes, IL1B (T-31C), IL6 (C-634G), IL8 (T-251A), IL10 (T-819C), tumor necrosis factor-A (TNFA) (T-1031C), and TNFA (C-857T), were genotyped by polymerase chain reaction. Information regarding alcohol intake, smoking habits, height, and weight was collected by a self-administered questionnaire. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were measured during a routine health check-up. Of the six SNPs genotyped, an IL6 polymorphism (rs1800796, C-634G) was most strongly associated with a liver damage marker, AST. Mean serum AST was significantly different among the three genotypes (mean ± SD, 22.7 ± 7.3 IU/L for CC, 22.8 ± 7.7 IU/L for CG, and 24.3 ± 8.6 IU/L for GG, p=0.011 by analysis of variance). The differences remained significant after adjustment for potential confounders by general linear models. The variations in mean serum AST and ALT levels were marked especially among men. Thus, the functional polymorphism IL6 C-634G may affect serum AST and ALT levels, possibly through different IL-6 production.","ja":"Cytokines, including interleukin-6 (IL-6), play an important role in the liver. The aim of this study was to investigate associations between common polymorphisms in potential functional promoters of cytokine genes and liver damage markers among enrollees of a large Japanese cohort study. Subjects included 3257 Japanese individuals (1608 men and 1649 women, aged 35-69 years). Six single nucleotide polymorphisms (SNPs) in the promoter regions of five cytokine genes, IL1B (T-31C), IL6 (C-634G), IL8 (T-251A), IL10 (T-819C), tumor necrosis factor-A (TNFA) (T-1031C), and TNFA (C-857T), were genotyped by polymerase chain reaction. Information regarding alcohol intake, smoking habits, height, and weight was collected by a self-administered questionnaire. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were measured during a routine health check-up. Of the six SNPs genotyped, an IL6 polymorphism (rs1800796, C-634G) was most strongly associated with a liver damage marker, AST. Mean serum AST was significantly different among the three genotypes (mean ± SD, 22.7 ± 7.3 IU/L for CC, 22.8 ± 7.7 IU/L for CG, and 24.3 ± 8.6 IU/L for GG, p=0.011 by analysis of variance). The differences remained significant after adjustment for potential confounders by general linear models. The variations in mean serum AST and ALT levels were marked especially among men. Thus, the functional polymorphism IL6 C-634G may affect serum AST and ALT levels, possibly through different IL-6 production."},"publication_date":"2015-01","publication_name":{"en":"Gene","ja":"Gene"},"volume":"Vol.557","number":"No.2","starting_page":"158","ending_page":"162","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.gene.2014.12.025"],"issn":["1879-0038"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/25437895","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=290649","label":"url"}],"paper_title":{"en":"Relationships of elevated levels of serum hepatic enzymes and alcohol intake with arterial stiffness in men.","ja":"Relationships of elevated levels of serum hepatic enzymes and alcohol intake with arterial stiffness in men."},"authors":{"en":[{"name":"Uemura Hirokazu"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Yamaguchi Miwa"},{"name":"Arisawa Kokichi"}],"ja":[{"name":"上村 浩一"},{"name":"勝浦-釜野 桜子"},{"name":"山口 美輪"},{"name":"有澤 孝吉"}]},"description":{"en":"The present study aimed to evaluate the relationships between elevated serum levels of hepatic enzymes and arterial stiffness and to investigate whether alcohol intake had a modifying effect on these relationships in Japanese men. A total of 647 eligible men aged 35-69 years who underwent measurement of brachial-ankle pulse wave velocity (baPWV) as an index of arterial stiffness were evaluated. Information on their lifestyle characteristics were obtained from a structured self-administered questionnaire. Serum biochemical factors, including alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT), were determined. The serum ALT and GGT levels were divided into tertiles, and their associations with baPWV values were evaluated using general linear models adjusted for potential confounding factors. The interaction effects between serum hepatic enzymes and alcohol intake on baPWV were further evaluated. Elevated serum ALT and GGT levels were proportionally associated with increased baPWV after adjusting for the multivariable covariates (P values for trend, 0.004 and 0.003, respectively). Further analyses revealed that the proportional associations between serum levels of hepatic enzymes and baPWV were striking in the subjects without alcohol intake but not in those with alcohol intake. The interaction effect between serum GGT level and alcohol intake on baPWV was significant (P for interaction, 0.042). These results demonstrate that elevated serum ALT and GGT levels are associated with increased arterial stiffness, independent of the classical atherosclerotic risk factors in Japanese men, and that the association of elevated serum GGT level with arterial stiffness differs according to alcohol intake.","ja":"The present study aimed to evaluate the relationships between elevated serum levels of hepatic enzymes and arterial stiffness and to investigate whether alcohol intake had a modifying effect on these relationships in Japanese men. A total of 647 eligible men aged 35-69 years who underwent measurement of brachial-ankle pulse wave velocity (baPWV) as an index of arterial stiffness were evaluated. Information on their lifestyle characteristics were obtained from a structured self-administered questionnaire. Serum biochemical factors, including alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT), were determined. The serum ALT and GGT levels were divided into tertiles, and their associations with baPWV values were evaluated using general linear models adjusted for potential confounding factors. The interaction effects between serum hepatic enzymes and alcohol intake on baPWV were further evaluated. Elevated serum ALT and GGT levels were proportionally associated with increased baPWV after adjusting for the multivariable covariates (P values for trend, 0.004 and 0.003, respectively). Further analyses revealed that the proportional associations between serum levels of hepatic enzymes and baPWV were striking in the subjects without alcohol intake but not in those with alcohol intake. The interaction effect between serum GGT level and alcohol intake on baPWV was significant (P for interaction, 0.042). These results demonstrate that elevated serum ALT and GGT levels are associated with increased arterial stiffness, independent of the classical atherosclerotic risk factors in Japanese men, and that the association of elevated serum GGT level with arterial stiffness differs according to alcohol intake."},"publication_date":"2014-11-22","publication_name":{"en":"Atherosclerosis","ja":"Atherosclerosis"},"volume":"Vol.238","number":"No.1","starting_page":"83","ending_page":"88","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.atherosclerosis.2014.11.021"],"issn":["1879-1484"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/25241219","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=290650","label":"url"}],"paper_title":{"en":"Family history of stroke is potentially associated with arterial stiffness in the Japanese population.","ja":"Family history of stroke is potentially associated with arterial stiffness in the Japanese population."},"authors":{"en":[{"name":"Uemura Hirokazu"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Yamaguchi Miwa"},{"name":"Nakamoto Mariko"},{"name":"Hiyoshi Mineyoshi"},{"name":"Arisawa Kokichi"}],"ja":[{"name":"上村 浩一"},{"name":"勝浦-釜野 桜子"},{"name":"山口 美輪"},{"name":"中本 真理子"},{"name":"Hiyoshi Mineyoshi"},{"name":"有澤 孝吉"}]},"description":{"en":"Studies on the association between family history of cardiovascular disease and arterial stiffness are rare. This study evaluated the possible relationship between family history of cardiovascular disease and arterial stiffness in the Japanese population, by measuring brachial-ankle pulse wave velocity (ba-PWV). A total of 1004 eligible subjects (664 men and 340 women) aged 35-69 years, who were enrolled in the baseline survey of a cohort study in Tokushima Prefecture (Japan) and who underwent ba-PWV measurement, were analysed. Information about their lifestyle characteristics and first-degree family histories of ischaemic heart disease (i.e. myocardial infarction or angina pectoris), stroke or hypertension were obtained from a structural self-administered questionnaire. Subjects of both sexes with a family history of stroke showed significantly higher multivariable-adjusted means of ba-PWV than those without that trait (P values were 0.001 in men and 0.002 in women), while those with a family history of ischaemic heart disease did not. Subjects of both sexes with a family history of hypertension showed significantly higher age-adjusted means of ba-PWV than those without that trait, although these differences disappeared after further adjusting for blood pressure or multivariable covariates. When family histories of these diseases were inserted simultaneously into the same model, these results did not alter substantially. A family history of stroke might be associated with increased arterial stiffness, independent of other known atherosclerotic risk factors, including hypertensive elements, in both sexes in the Japanese population.","ja":"Studies on the association between family history of cardiovascular disease and arterial stiffness are rare. This study evaluated the possible relationship between family history of cardiovascular disease and arterial stiffness in the Japanese population, by measuring brachial-ankle pulse wave velocity (ba-PWV). A total of 1004 eligible subjects (664 men and 340 women) aged 35-69 years, who were enrolled in the baseline survey of a cohort study in Tokushima Prefecture (Japan) and who underwent ba-PWV measurement, were analysed. Information about their lifestyle characteristics and first-degree family histories of ischaemic heart disease (i.e. myocardial infarction or angina pectoris), stroke or hypertension were obtained from a structural self-administered questionnaire. Subjects of both sexes with a family history of stroke showed significantly higher multivariable-adjusted means of ba-PWV than those without that trait (P values were 0.001 in men and 0.002 in women), while those with a family history of ischaemic heart disease did not. Subjects of both sexes with a family history of hypertension showed significantly higher age-adjusted means of ba-PWV than those without that trait, although these differences disappeared after further adjusting for blood pressure or multivariable covariates. When family histories of these diseases were inserted simultaneously into the same model, these results did not alter substantially. A family history of stroke might be associated with increased arterial stiffness, independent of other known atherosclerotic risk factors, including hypertensive elements, in both sexes in the Japanese population."},"publication_date":"2014-09-16","publication_name":{"en":"Archives of Cardiovascular Diseases","ja":"Archives of Cardiovascular Diseases"},"volume":"Vol.107","number":"No.12","starting_page":"654","ending_page":"663","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.acvd.2014.07.047"],"issn":["1875-2128"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/25192171","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=290654","label":"url"}],"paper_title":{"en":"Association between dietary calcium intake and arterial stiffness according to dietary vitamin D intake in men.","ja":"Association between dietary calcium intake and arterial stiffness according to dietary vitamin D intake in men."},"authors":{"en":[{"name":"Uemura Hirokazu"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Yamaguchi Miwa"},{"name":"Nakamoto Mariko"},{"name":"Hiyoshi Mineyoshi"},{"name":"Arisawa Kokichi"}],"ja":[{"name":"上村 浩一"},{"name":"勝浦-釜野 桜子"},{"name":"山口 美輪"},{"name":"中本 真理子"},{"name":"Hiyoshi Mineyoshi"},{"name":"有澤 孝吉"}]},"description":{"en":"Studies on the associations of dietary Ca and vitamin D intakes with arterial stiffness are scarce. In the present study, these associations were evaluated in Japanese men. Data from a total of 535 eligible men, aged 35-69 years, who participated in the baseline survey of a cohort study in Tokushima Prefecture, Japan, and underwent brachial-ankle pulse wave velocity (ba-PWV) measurements were analysed. ba-PWV is a measure of arterial stiffness and is recognised as a marker of atherosclerotic vascular damage. Information regarding the cohort's lifestyle characteristics including dietary behaviour over the past year was obtained from a structured self-administered questionnaire. Dietary Ca and vitamin D intakes were adjusted for total energy intake using the residual method and divided into quartiles; the highest quartile was used as the reference. General linear models were used to evaluate the associations between dietary Ca and vitamin D intakes and ba-PWV values adjusted for probable covariates. The association between dietary Ca intake and ba-PWV was further evaluated using similar general linear models stratified by dietary vitamin D intake (median or below/above median). Dietary Ca intake was found to be significantly inversely associated with ba-PWV after adjusting for probable covariates (P for trend = 0·020). However, no such association was observed between dietary vitamin D intake and ba-PWV. The inverse association between dietary Ca intake and ba-PWV was striking in subjects with higher dietary vitamin D intake. However, no association was found in subjects with lower dietary vitamin D intake. These results indicate that adequate dietary Ca and vitamin D intakes may be protective against the development of arterial stiffness in Japanese men.","ja":"Studies on the associations of dietary Ca and vitamin D intakes with arterial stiffness are scarce. In the present study, these associations were evaluated in Japanese men. Data from a total of 535 eligible men, aged 35-69 years, who participated in the baseline survey of a cohort study in Tokushima Prefecture, Japan, and underwent brachial-ankle pulse wave velocity (ba-PWV) measurements were analysed. ba-PWV is a measure of arterial stiffness and is recognised as a marker of atherosclerotic vascular damage. Information regarding the cohort's lifestyle characteristics including dietary behaviour over the past year was obtained from a structured self-administered questionnaire. Dietary Ca and vitamin D intakes were adjusted for total energy intake using the residual method and divided into quartiles; the highest quartile was used as the reference. General linear models were used to evaluate the associations between dietary Ca and vitamin D intakes and ba-PWV values adjusted for probable covariates. The association between dietary Ca intake and ba-PWV was further evaluated using similar general linear models stratified by dietary vitamin D intake (median or below/above median). Dietary Ca intake was found to be significantly inversely associated with ba-PWV after adjusting for probable covariates (P for trend = 0·020). However, no such association was observed between dietary vitamin D intake and ba-PWV. The inverse association between dietary Ca intake and ba-PWV was striking in subjects with higher dietary vitamin D intake. However, no association was found in subjects with lower dietary vitamin D intake. These results indicate that adequate dietary Ca and vitamin D intakes may be protective against the development of arterial stiffness in Japanese men."},"publication_date":"2014-09-05","publication_name":{"en":"British Journal of Nutrition","ja":"British Journal of Nutrition"},"volume":"Vol.112","number":"No.8","starting_page":"1333","ending_page":"1340","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1017/S0007114514002153"],"issn":["1475-2662"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"http://ci.nii.ac.jp/naid/130004822739/","label":"url"},{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/109582","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/25264052","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1390282679219931776/","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-84907552290&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=275761","label":"url"}],"paper_title":{"en":"Associations of dietary patterns with metabolic syndrome and insulin resistance: a cross-sectional study in a Japanese population","ja":"Associations of dietary patterns with metabolic syndrome and insulin resistance: a cross-sectional study in a Japanese population"},"authors":{"en":[{"name":"Arisawa Kokichi"},{"name":"Uemura Hirokazu"},{"name":"Yamaguchi Miwa"},{"name":"Nakamoto Mariko"},{"name":"Hiyoshi Mineyoshi"},{"name":"Sawachika Fusakazu"},{"name":"Katsuura-Kamano Sakurako"}],"ja":[{"name":"有澤 孝吉"},{"name":"上村 浩一"},{"name":"山口 美輪"},{"name":"Nakamoto Mariko"},{"name":"日吉 峰麗"},{"name":"澤近 房和"},{"name":"勝浦-釜野 桜子"}]},"description":{"en":"The associations of dietary patterns with metabolic syndrome (MetS) and insulin resistance have not been fully investigated in the Japanese population. A cross-sectional study was performed on 513 subjects without treatment for diabetes who had participated in the baseline survey of a cohort study in Tokushima Prefecture, Japan. Frequencies of consumption of 46 foods and beverages were assessed using a questionnaire. MetS was diagnosed using the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria. Logistic and linear regression analyses were used to examine the associations of the dietary patterns with the prevalence of MetS, its components, and the Homeostasis Model of Assessment-Insulin Resistance (HOMA-IR). Using principal component analysis, four dietary patterns were extracted: prudent diet (high intake of vegetables and fruits); high fat/Western (high intake of fried foods, fried dishes and meat); bread and dairy products; and seafood patterns. After adjustment for sex, age, and other potential confounders, prudent diet pattern scores were inversely correlated with the prevalence of reduced serum high-density lipoprotein cholesterol (P=0.04) and high blood pressure (P=0.05), and bread and dairy products pattern scores were correlated with a lower prevalence of abdominal obesity (P=0.04) and high plasma glucose (P=0.04). The high fat/Western pattern was positively correlated with HOMA-IR (P=0.04). Prudent dietary pattern and bread and dairy products pattern may be correlated with a lower prevalence of some components of MetS. A high fat/Western dietary pattern may be positively associated with insulin resistance in the Japanese population.","ja":"The associations of dietary patterns with metabolic syndrome (MetS) and insulin resistance have not been fully investigated in the Japanese population. A cross-sectional study was performed on 513 subjects without treatment for diabetes who had participated in the baseline survey of a cohort study in Tokushima Prefecture, Japan. Frequencies of consumption of 46 foods and beverages were assessed using a questionnaire. MetS was diagnosed using the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria. Logistic and linear regression analyses were used to examine the associations of the dietary patterns with the prevalence of MetS, its components, and the Homeostasis Model of Assessment-Insulin Resistance (HOMA-IR). Using principal component analysis, four dietary patterns were extracted: prudent diet (high intake of vegetables and fruits); high fat/Western (high intake of fried foods, fried dishes and meat); bread and dairy products; and seafood patterns. After adjustment for sex, age, and other potential confounders, prudent diet pattern scores were inversely correlated with the prevalence of reduced serum high-density lipoprotein cholesterol (P=0.04) and high blood pressure (P=0.05), and bread and dairy products pattern scores were correlated with a lower prevalence of abdominal obesity (P=0.04) and high plasma glucose (P=0.04). The high fat/Western pattern was positively correlated with HOMA-IR (P=0.04). Prudent dietary pattern and bread and dairy products pattern may be correlated with a lower prevalence of some components of MetS. A high fat/Western dietary pattern may be positively associated with insulin resistance in the Japanese population."},"publication_date":"2014-08","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.61","number":"No.3,4","starting_page":"333","ending_page":"344","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.61.333"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/24880622","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-84906935301&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=278543","label":"url"}],"paper_title":{"en":"A polymorphism near MC4R gene (rs17782313) is associated with serum triglyceride levels in the general Japanese population: the J-MICC Study","ja":"A polymorphism near MC4R gene (rs17782313) is associated with serum triglyceride levels in the general Japanese population: the J-MICC Study"},"authors":{"en":[{"name":"Kamano Sakurako"},{"name":"Uemura Hirokazu"},{"name":"Arisawa Kokichi"},{"name":"Yamaguchi Miwa"},{"name":"Nobuyuki Hamajima"},{"name":"Kenji Wakai"},{"name":"Rieko Okada"},{"name":"Sadao Suzuki"},{"name":"Naoto Taguchi"},{"name":"Yoshikuni Kita"},{"name":"Keizo Ohnaka"},{"name":"Tara Sefanya Kairupan"},{"name":"Daisuke Matsui"},{"name":"Isao Oze"},{"name":"Haruo Mikami"},{"name":"Michiaki Kubo"},{"name":"Hideo Tanaka"}],"ja":[{"name":"釜野 桜子"},{"name":"上村 浩一"},{"name":"有澤 孝吉"},{"name":"山口 美輪"},{"name":"Nobuyuki Hamajima"},{"name":"Kenji Wakai"},{"name":"Rieko Okada"},{"name":"Sadao Suzuki"},{"name":"Naoto Taguchi"},{"name":"Yoshikuni Kita"},{"name":"Keizo Ohnaka"},{"name":"Tara Sefanya Kairupan"},{"name":"Daisuke Matsui"},{"name":"Isao Oze"},{"name":"Haruo Mikami"},{"name":"Michiaki Kubo"},{"name":"Hideo Tanaka"}]},"description":{"en":"Previously reported associations of a common polymorphism near melanocortin-4 receptor (MC4R) gene (rs17782313) with BMI/obesity were inconsistent, especially in East Asia, and the associations of the polymorphism with serum lipid levels have not been fully elucidated. This study evaluated the association between rs17782313 and obesity-related traits and serum lipid levels in the general Japanese population. A total of 2,035 subjects (aged 35-69 years, 1,024 males and 1,011 females) enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. We examined the associations between near MC4R polymorphism (rs17782313) and obesity-related traits [height, weight, body mass index (BMI), weight change from 20 years old], serum lipid levels (triglycerides, total and HDL-cholesterol), and intake of nutrients (total energy and macronutrients). Polymorphism of rs17782313 (minor C allele) was positively associated with serum triglyceride levels (P for trend = 0.020) adjusted for age and sex. Analysis using a general linear model revealed that the number of minor C alleles was positively associated with serum triglyceride levels after adjustment for age, sex, and potential confounders (P for trend = 0.004). Statistical significance did not change after further adjustment for total energy intake and BMI. There was no significant association between rs17782313 and obesity-related traits including BMI. Interactions between rs17782313 and sex, BMI, or total energy intake for triglyceride levels were not significant. To our knowledge, this study demonstrated for the first time that rs17782313 was associated with serum triglyceride levels in Asian population. Further studies are needed to confirm this result.","ja":"Previously reported associations of a common polymorphism near melanocortin-4 receptor (MC4R) gene (rs17782313) with BMI/obesity were inconsistent, especially in East Asia, and the associations of the polymorphism with serum lipid levels have not been fully elucidated. This study evaluated the association between rs17782313 and obesity-related traits and serum lipid levels in the general Japanese population. A total of 2,035 subjects (aged 35-69 years, 1,024 males and 1,011 females) enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. We examined the associations between near MC4R polymorphism (rs17782313) and obesity-related traits [height, weight, body mass index (BMI), weight change from 20 years old], serum lipid levels (triglycerides, total and HDL-cholesterol), and intake of nutrients (total energy and macronutrients). Polymorphism of rs17782313 (minor C allele) was positively associated with serum triglyceride levels (P for trend = 0.020) adjusted for age and sex. Analysis using a general linear model revealed that the number of minor C alleles was positively associated with serum triglyceride levels after adjustment for age, sex, and potential confounders (P for trend = 0.004). Statistical significance did not change after further adjustment for total energy intake and BMI. There was no significant association between rs17782313 and obesity-related traits including BMI. Interactions between rs17782313 and sex, BMI, or total energy intake for triglyceride levels were not significant. To our knowledge, this study demonstrated for the first time that rs17782313 was associated with serum triglyceride levels in Asian population. Further studies are needed to confirm this result."},"publication_date":"2014-06-01","publication_name":{"en":"Endocrine","ja":"Endocrine"},"volume":"Vol.47","number":"No.1","starting_page":"81","ending_page":"89","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s12020-014-0306-y"],"issn":["1355-008X"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/24755715","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-84899673057&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=277784","label":"url"}],"paper_title":{"en":"Serum hepatic enzyme activity and alcohol drinking status in relation to the prevalence of metabolic syndrome in the general Japanese population.","ja":"Serum hepatic enzyme activity and alcohol drinking status in relation to the prevalence of metabolic syndrome in the general Japanese population."},"authors":{"en":[{"name":"Uemura Hirokazu"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Yamaguchi Miwa"},{"name":"Sawachika Fusakazu"},{"name":"Arisawa Kokichi"}],"ja":[{"name":"上村 浩一"},{"name":"勝浦-釜野 桜子"},{"name":"山口 美輪"},{"name":"澤近 房和"},{"name":"有澤 孝吉"}]},"description":{"en":"Studies on the combined associations of elevated serum hepatic enzyme activity and alcohol drinking with metabolic syndrome are rare. Our objectives were to evaluate the associations of elevated serum hepatic enzyme activity with the prevalence of metabolic syndrome in the general Japanese population and whether alcohol drinking had a modifying effect on these associations. We conducted a cross-sectional study with 1,027 men and 1,152 women throughout Japan during 2002-2010. Biochemical factors including alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) were determined in overnight fasting blood, and a survey on lifestyle was conducted by questionnaire. Serum ALT and GGT levels were divided into tertiles in men and women, and their associations with the prevalence of metabolic syndrome were evaluated by logistic regressions. Elevated serum ALT and GGT, even within the reference range, were independently associated with increased metabolic syndrome prevalence and were associated with most of its components in both sexes, except for the association between GGT and low high-density lipoprotein (HDL) cholesterol in men. Stratified analyses by alcohol drinking status revealed that within the same tertile category of serum ALT and GGT, subjects classified as alcohol abstainers showed higher adjusted odds ratios for metabolic syndrome prevalence than those classified as regular alcohol drinkers in both sexes. The interaction effects of serum GGT with alcohol drinking status on metabolic syndrome prevalence were significant in both sexes. These results suggest that elevated serum ALT and GGT, even within the reference range, are independently associated with increased metabolic syndrome prevalence, especially in alcohol abstainers, in Japanese men and women.","ja":"Studies on the combined associations of elevated serum hepatic enzyme activity and alcohol drinking with metabolic syndrome are rare. Our objectives were to evaluate the associations of elevated serum hepatic enzyme activity with the prevalence of metabolic syndrome in the general Japanese population and whether alcohol drinking had a modifying effect on these associations. We conducted a cross-sectional study with 1,027 men and 1,152 women throughout Japan during 2002-2010. Biochemical factors including alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) were determined in overnight fasting blood, and a survey on lifestyle was conducted by questionnaire. Serum ALT and GGT levels were divided into tertiles in men and women, and their associations with the prevalence of metabolic syndrome were evaluated by logistic regressions. Elevated serum ALT and GGT, even within the reference range, were independently associated with increased metabolic syndrome prevalence and were associated with most of its components in both sexes, except for the association between GGT and low high-density lipoprotein (HDL) cholesterol in men. Stratified analyses by alcohol drinking status revealed that within the same tertile category of serum ALT and GGT, subjects classified as alcohol abstainers showed higher adjusted odds ratios for metabolic syndrome prevalence than those classified as regular alcohol drinkers in both sexes. The interaction effects of serum GGT with alcohol drinking status on metabolic syndrome prevalence were significant in both sexes. These results suggest that elevated serum ALT and GGT, even within the reference range, are independently associated with increased metabolic syndrome prevalence, especially in alcohol abstainers, in Japanese men and women."},"publication_date":"2014-04-22","publication_name":{"en":"PLoS ONE","ja":"PLoS ONE"},"volume":"Vol.9","number":"No.4","starting_page":"e95981","ending_page":"e95981","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1371/journal.pone.0095981"],"issn":["1932-6203"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/105906","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/24741683","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-84893935930&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=288179","label":"url"}],"paper_title":{"en":"Are multifocal motor neuropathy patients underdiagnosed? An epidemiological survey in Japan","ja":"Are multifocal motor neuropathy patients underdiagnosed? An epidemiological survey in Japan"},"authors":{"en":[{"name":"Miyashiro Ai"},{"name":"Matsui Naoko"},{"name":"Shimatani Yoshimitsu"},{"name":"Nodera Hiroyuki"},{"name":"Izumi Yuishin"},{"name":"Kawabata Satoshi"},{"name":"Imai Tomihiro"},{"name":"Baba Masayuki"},{"name":"Komori Tetsuo"},{"name":"Sonoo Masahiro"},{"name":"Maezaki Takahiro"},{"name":"Kawamata Jun"},{"name":"Hitomi Takefumi"},{"name":"Kohara Nobuo"},{"name":"Arimura Kimiyoshi"},{"name":"Hashimoto Shuji"},{"name":"Arisawa Kokichi"},{"name":"Kusunoki Susumu"},{"name":"Kaji Ryuji"}],"ja":[{"name":"宮城 愛"},{"name":"松井 尚子"},{"name":"島谷 佳光"},{"name":"野寺 裕之"},{"name":"和泉 唯信"},{"name":"Kawabata Satoshi"},{"name":"Imai Tomihiro"},{"name":"Baba Masayuki"},{"name":"Komori Tetsuo"},{"name":"Sonoo Masahiro"},{"name":"Maezaki Takahiro"},{"name":"Kawamata Jun"},{"name":"Hitomi Takefumi"},{"name":"Kohara Nobuo"},{"name":"Arimura Kimiyoshi"},{"name":"Hashimoto Shuji"},{"name":"有澤 孝吉"},{"name":"Kusunoki Susumu"},{"name":"梶 龍兒"}]},"description":{"en":"Our objective was to do an epidemiologic survey of patients with multifocal motor neuropathy (MMN) in comparison with those with amyotrophic lateral sclerosis (ALS) in Japan. In this retrospective study, we examined 46 patients with MMN and 1,051 patients with ALS from major neuromuscular centers in Japan from 2005 to 2009. Diagnosis was based on the European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS) and the revised El Escorial criteria. The efficacy of intravenous immunoglobulin (IVIg) was also taken into consideration in the diagnosis of MMN. The ratio of MMN to ALS patients (0-0.10) varied among the centers, but mostly converged to 0.05. The prevalence was estimated to be 0.29 MMN patients and 6.63 ALS patients per 100,000 population. The frequency of MMN patients was around 1 out of 20 ALS patients, and MMN was possibly underdiagnosed in some centers.","ja":"Our objective was to do an epidemiologic survey of patients with multifocal motor neuropathy (MMN) in comparison with those with amyotrophic lateral sclerosis (ALS) in Japan. In this retrospective study, we examined 46 patients with MMN and 1,051 patients with ALS from major neuromuscular centers in Japan from 2005 to 2009. Diagnosis was based on the European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS) and the revised El Escorial criteria. The efficacy of intravenous immunoglobulin (IVIg) was also taken into consideration in the diagnosis of MMN. The ratio of MMN to ALS patients (0-0.10) varied among the centers, but mostly converged to 0.05. The prevalence was estimated to be 0.29 MMN patients and 6.63 ALS patients per 100,000 population. The frequency of MMN patients was around 1 out of 20 ALS patients, and MMN was possibly underdiagnosed in some centers."},"publication_date":"2014-03","publication_name":{"en":"Muscle & Nerve","ja":"Muscle & Nerve"},"volume":"Vol.49","number":"No.3","starting_page":"357","ending_page":"361","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1002/mus.23930"],"issn":["0148-639X"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/24164272","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=277785","label":"url"}],"paper_title":{"en":"Effect of ultra-low-dose estradiol and dydrogesterone on arterial stiffness in postmenopausal women.","ja":"Effect of ultra-low-dose estradiol and dydrogesterone on arterial stiffness in postmenopausal women."},"authors":{"en":[{"name":"Matsui Sumika"},{"name":"Yasui Toshiyuki"},{"name":"Tani A"},{"name":"Katou Takeshi"},{"name":"Uemura Hirokazu"},{"name":"Kuwahara Akira"},{"name":"Matsuzaki Toshiya"},{"name":"Arisawa Kokichi"},{"name":"Irahara Minoru"}],"ja":[{"name":"松井 寿美佳"},{"name":"安井 敏之"},{"name":"Tani A"},{"name":"加藤 剛志"},{"name":"上村 浩一"},{"name":"桑原 章"},{"name":"松崎 利也"},{"name":"有澤 孝吉"},{"name":"苛原 稔"}]},"description":{"en":"Abstract Background Ultra-low-dose estradiol is known to improve menopausal symptoms and increase bone mineral density. However, the effect of ultra-low-dose estradiol on vascular function has not been clarified. Objectives We examined the effects of ultra-low-dose estradiol on brachial-ankle pulse wave velocity (baPWV) and circulating markers of cardiovascular risk. Patients and methods Twenty-eight postmenopausal women were enrolled in this study. Fourteen women received oral estradiol (0.5 mg) and dydrogesterone (5 mg) every day for 12 months (ultra-low-dose group) as hormone replacement therapy (HRT) and 14 women as a control group did not receive HRT. The baPWV, lipid profiles, homeostasis model assessment of insulin resistance (HOMA-IR) and vascular inflammatory markers were measured. Results The baPWV level significantly decreased in the ultra-low-dose group (p = 0.037), while the baPWV level did not significantly change in the control group. HOMA-IR tended to decrease in the ultra-low-dose group (p = 0.076). Systolic blood pressure and diastolic blood pressure did not change significantly in either group. Conclusion An HRT regimen using oral ultra-low-dose estradiol and dydrogesterone has an effect on arterial stiffness and insulin resistance.","ja":"Abstract Background Ultra-low-dose estradiol is known to improve menopausal symptoms and increase bone mineral density. However, the effect of ultra-low-dose estradiol on vascular function has not been clarified. Objectives We examined the effects of ultra-low-dose estradiol on brachial-ankle pulse wave velocity (baPWV) and circulating markers of cardiovascular risk. Patients and methods Twenty-eight postmenopausal women were enrolled in this study. Fourteen women received oral estradiol (0.5 mg) and dydrogesterone (5 mg) every day for 12 months (ultra-low-dose group) as hormone replacement therapy (HRT) and 14 women as a control group did not receive HRT. The baPWV, lipid profiles, homeostasis model assessment of insulin resistance (HOMA-IR) and vascular inflammatory markers were measured. Results The baPWV level significantly decreased in the ultra-low-dose group (p = 0.037), while the baPWV level did not significantly change in the control group. HOMA-IR tended to decrease in the ultra-low-dose group (p = 0.076). Systolic blood pressure and diastolic blood pressure did not change significantly in either group. Conclusion An HRT regimen using oral ultra-low-dose estradiol and dydrogesterone has an effect on arterial stiffness and insulin resistance."},"publication_date":"2013-12-16","publication_name":{"en":"Climacteric","ja":"Climacteric"},"volume":"Vol.17","number":"No.2","starting_page":"191","ending_page":"196","languages":["eng"],"referee":true,"identifiers":{"doi":["10.3109/13697137.2013.856399"],"issn":["1473-0804"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=277788","label":"url"}],"paper_title":{"en":"A family history of diabetes is not associated with arterial stiffness in non-diabetic Japanese population","ja":"A family history of diabetes is not associated with arterial stiffness in non-diabetic Japanese population"},"authors":{"en":[{"name":"Uemura Hirokazu"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Yamaguchi Miwa"},{"name":"Nakamoto Mariko"},{"name":"Mineyoshi Hiyoshi"},{"name":"Fusakazu Sawachika"},{"name":"Arisawa Kokichi"}],"ja":[{"name":"上村 浩一"},{"name":"勝浦-釜野 桜子"},{"name":"山口 美輪"},{"name":"中本 真理子"},{"name":"Mineyoshi Hiyoshi"},{"name":"澤近 房和"},{"name":"有澤 孝吉"}]},"publication_date":"2013-11-21","publication_name":{"en":"Open Journal of Epidemiology","ja":"Open Journal of Epidemiology"},"volume":"Vol.3","number":"No.4","starting_page":"Article","ending_page":"ID:39843,7pages","languages":["eng"],"referee":true,"identifiers":{"doi":["10.4236/ojepi.2013.34025"],"issn":["2165-7459"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/23014754","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=279321","label":"url"}],"paper_title":{"en":"Association between blood levels of PCDDs/PCDFs/dioxin-like PCBs and history of allergic and other diseases in the Japanese population.","ja":"Association between blood levels of PCDDs/PCDFs/dioxin-like PCBs and history of allergic and other diseases in the Japanese population."},"authors":{"en":[{"name":"Nakamoto Mariko"},{"name":"Arisawa Kokichi"},{"name":"Uemura Hirokazu"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Takami Hidenobu"},{"name":"Sawachika Fusakazu"},{"name":"Yamaguchi Miwa"},{"name":"Juta Tomoya"},{"name":"Sakai Tohru"},{"name":"Toda Eisaku"},{"name":"Mori Kei"},{"name":"Hasegawa Manabu"},{"name":"Tanto Masaharu"},{"name":"Shima Masayuki"},{"name":"Sumiyoshi Yoshio"},{"name":"Morinaga Kenji"},{"name":"Kodama Kazunori"},{"name":"Suzuki Takaichiro"},{"name":"Nagai Masaki"},{"name":"Satoh Hiroshi"}],"ja":[{"name":"中本 真理子"},{"name":"有澤 孝吉"},{"name":"上村 浩一"},{"name":"勝浦-釜野 桜子"},{"name":"Takami Hidenobu"},{"name":"Sawachika Fusakazu"},{"name":"山口 美輪"},{"name":"Juta Tomoya"},{"name":"酒井 徹"},{"name":"Toda Eisaku"},{"name":"Mori Kei"},{"name":"Hasegawa Manabu"},{"name":"Tanto Masaharu"},{"name":"Shima Masayuki"},{"name":"Sumiyoshi Yoshio"},{"name":"Morinaga Kenji"},{"name":"Kodama Kazunori"},{"name":"Suzuki Takaichiro"},{"name":"Nagai Masaki"},{"name":"Satoh Hiroshi"}]},"description":{"en":"Previous studies reported that exposure to dioxins was associated with an increased risk of various diseases in general populations. The aim of this study was to examine the association between levels of dioxins in blood and allergic and other diseases. We conducted a cross-sectional study on 1,063 men and 1,201 women (aged 15-76 years), who were living throughout Japan and not occupationally exposed to dioxins, during 2002-2010. In fasting blood samples, polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like PCBs (DL-PCBs) were analyzed by isotope dilution high-resolution gas chromatography/mass spectrometry. We obtained information on life style and self-reported history of diseases using a questionnaire. Blood pressure, blood levels of hemoglobin A1c, and serum lipids were also measured. Multiple logistic regression models were used to analyze the association between dioxin levels in blood and various diseases. Toxic equivalents of PCDDs/PCDFs and total dioxins showed significant inverse dose-response relationships with atopic dermatitis, after adjustments for potential confounders. The highest quartile for total dioxins had an adjusted odds ratio of 0.26 (95 % confidence interval 0.08-0.70) compared to the reference group (first quartile). The odds ratios for hypertension, diabetes mellitus, hyperlipidemia, gout in men, and gynecologic diseases in women significantly increased with increasing toxic equivalents of PCDDs/PCDFs, DL-PCBs, and total dioxins in blood. The present findings suggest that background exposure to dioxins was associated with reduced risk of atopic dermatitis. The results also support the idea that low-level exposure to dioxins is associated with an increased risk of diabetes, hypertension, and hyperlipidemia.","ja":"Previous studies reported that exposure to dioxins was associated with an increased risk of various diseases in general populations. The aim of this study was to examine the association between levels of dioxins in blood and allergic and other diseases. We conducted a cross-sectional study on 1,063 men and 1,201 women (aged 15-76 years), who were living throughout Japan and not occupationally exposed to dioxins, during 2002-2010. In fasting blood samples, polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like PCBs (DL-PCBs) were analyzed by isotope dilution high-resolution gas chromatography/mass spectrometry. We obtained information on life style and self-reported history of diseases using a questionnaire. Blood pressure, blood levels of hemoglobin A1c, and serum lipids were also measured. Multiple logistic regression models were used to analyze the association between dioxin levels in blood and various diseases. Toxic equivalents of PCDDs/PCDFs and total dioxins showed significant inverse dose-response relationships with atopic dermatitis, after adjustments for potential confounders. The highest quartile for total dioxins had an adjusted odds ratio of 0.26 (95 % confidence interval 0.08-0.70) compared to the reference group (first quartile). The odds ratios for hypertension, diabetes mellitus, hyperlipidemia, gout in men, and gynecologic diseases in women significantly increased with increasing toxic equivalents of PCDDs/PCDFs, DL-PCBs, and total dioxins in blood. The present findings suggest that background exposure to dioxins was associated with reduced risk of atopic dermatitis. The results also support the idea that low-level exposure to dioxins is associated with an increased risk of diabetes, hypertension, and hyperlipidemia."},"publication_date":"2013-11","publication_name":{"en":"International Archives of Occupational and Environmental Health","ja":"International Archives of Occupational and Environmental Health"},"volume":"Vol.86","number":"No.8","starting_page":"849","ending_page":"859","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1007/s00420-012-0819-8"],"issn":["1432-1246"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=283272","label":"url"}],"paper_title":{"en":"Elbow Injuries in Youth Baseball Players without Prior Elbow Pain : a One-year Prospective Study","ja":"Elbow Injuries in Youth Baseball Players without Prior Elbow Pain : a One-year Prospective Study"},"authors":{"en":[{"name":"Matsuura Tetsuya"},{"name":"Suzue Naoto"},{"name":"Kashiwaguchi Shinji"},{"name":"Arisawa Kokichi"},{"name":"Yasui Natsuo"}],"ja":[{"name":"松浦 哲也"},{"name":"鈴江 直人"},{"name":"柏口 新二"},{"name":"有澤 孝吉"},{"name":"安井 夏生"}]},"publication_date":"2013-10","publication_name":{"en":"Orthopaedic Journal of Sports Medicine","ja":"Orthopaedic Journal of Sports Medicine"},"volume":"Vol.1","number":"No.Oct","starting_page":"1","ending_page":"5","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1177/2325967113509948"],"issn":["2325-9671"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/23886980","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=268824","label":"url"}],"paper_title":{"en":"Abundant daily non-sedentary activity is associated with reduced prevalence of metabolic syndrome and insulin resistance.","ja":"Abundant daily non-sedentary activity is associated with reduced prevalence of metabolic syndrome and insulin resistance."},"authors":{"en":[{"name":"Uemura Hirokazu"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Yamaguchi Miwa"},{"name":"Nakamoto Mariko"},{"name":"Hiyoshi M"},{"name":"Arisawa Kokichi"}],"ja":[{"name":"上村 浩一"},{"name":"勝浦-釜野 桜子"},{"name":"山口 美輪"},{"name":"中本 真理子"},{"name":"Hiyoshi M"},{"name":"有澤 孝吉"}]},"description":{"en":"Background: Non-exercise activity thermogenesis (NEAT) has recently drawn attention because of its potential to prevent weight gain. Aim: This study evaluated the relationships between the duration of daily non-sedentary activities and the prevalence of metabolic syndrome and insulin resistance in the Japanese population. Material/Subjects and Methods: A total of 518 eligible subjects (380 men and 138 women) who attended the Tokushima Prefectural General Health Checkup Center and participated in the baseline survey of a cohort study conducted in Tokushima Prefecture, Japan were analyzed. Information about lifestyle characteristics including leisure-time exercise and daily non-exercise activities was obtained from a questionnaire. Logistic and multiple linear regression analyses were performed to evaluate the associations between the duration of daily non-exercise non-sedentary activities (beyond sitting) and prevalence of metabolic syndrome (and its components) and insulin resistance. Results: Subjects with longer duration of daily non-sedentary activities had significantly lower adjusted odds ratios for metabolic syndrome (P for trend = 0.024), abdominal obesity (P for trend = 0.023), and low HDL-cholesterol levels (P for trend = 0.002), after adjustment for sex, age, and other probable covariates including leisure-time exercise. Longer duration of daily non-sedentary activities was further associated with lower Homeostasis Model of Assessment-Insulin Resistance (HOMA-IR) values (P for trend = 0.009). Conclusions: Our results suggest that abundant daily non-sedentary activity might be associated with a lower prevalence of metabolic syndrome, especially for the components of central obesity and low HDL-cholesterol levels, and with a lower prevalence of insulin resistance, independent of leisure-time exercise.","ja":"Background: Non-exercise activity thermogenesis (NEAT) has recently drawn attention because of its potential to prevent weight gain. Aim: This study evaluated the relationships between the duration of daily non-sedentary activities and the prevalence of metabolic syndrome and insulin resistance in the Japanese population. Material/Subjects and Methods: A total of 518 eligible subjects (380 men and 138 women) who attended the Tokushima Prefectural General Health Checkup Center and participated in the baseline survey of a cohort study conducted in Tokushima Prefecture, Japan were analyzed. Information about lifestyle characteristics including leisure-time exercise and daily non-exercise activities was obtained from a questionnaire. Logistic and multiple linear regression analyses were performed to evaluate the associations between the duration of daily non-exercise non-sedentary activities (beyond sitting) and prevalence of metabolic syndrome (and its components) and insulin resistance. Results: Subjects with longer duration of daily non-sedentary activities had significantly lower adjusted odds ratios for metabolic syndrome (P for trend = 0.024), abdominal obesity (P for trend = 0.023), and low HDL-cholesterol levels (P for trend = 0.002), after adjustment for sex, age, and other probable covariates including leisure-time exercise. Longer duration of daily non-sedentary activities was further associated with lower Homeostasis Model of Assessment-Insulin Resistance (HOMA-IR) values (P for trend = 0.009). Conclusions: Our results suggest that abundant daily non-sedentary activity might be associated with a lower prevalence of metabolic syndrome, especially for the components of central obesity and low HDL-cholesterol levels, and with a lower prevalence of insulin resistance, independent of leisure-time exercise."},"publication_date":"2013-07-26","publication_name":{"en":"Journal of Endocrinological Investigation","ja":"Journal of Endocrinological Investigation"},"languages":["eng"],"referee":true,"identifiers":{"doi":["10.3275/9066"],"issn":["1720-8386"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/23859993","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=268823","label":"url"}],"paper_title":{"en":"Consumption of coffee, not green tea, is inversely associated with arterial stiffness in Japanese men.","ja":"Consumption of coffee, not green tea, is inversely associated with arterial stiffness in Japanese men."},"authors":{"en":[{"name":"Uemura Hirokazu"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Yamaguchi Miwa"},{"name":"Nakamoto Mariko"},{"name":"Hiyoshi M"},{"name":"Arisawa Kokichi"}],"ja":[{"name":"上村 浩一"},{"name":"勝浦-釜野 桜子"},{"name":"山口 美輪"},{"name":"中本 真理子"},{"name":"Hiyoshi M"},{"name":"有澤 孝吉"}]},"description":{"en":"Background/Objectives:Studies on the associations between coffee and green tea consumption and arterial stiffness are rare. This study evaluated the possible relationships between coffee and green tea consumption and brachial-ankle pulse wave velocity (ba-PWV) values in Japanese men.Subjects/Methods:In total, 540 eligible men who enrolled in the baseline survey of a cohort study in Tokushima Prefecture, Japan, and who underwent ba-PWV measurement were analyzed. Information about lifestyle characteristics including coffee and green tea intake were obtained from a structural self-administered questionnaire. Multiple linear regression analyses were used to evaluate the associations between coffee and green tea consumption and ba-PWV.Results:Subjects with greater coffee consumption were younger and showed higher proportions of current smoking and alcohol consumption. Subjects with greater green tea consumption were older and showed lower proportions of current smoking and alcohol consumption. Greater coffee consumption was significantly inversely associated with ba-PWV after the adjustment for probable covariates, including serum low-density lipoprotein cholesterol and high-density lipoprotein cholesterol (P for trend =0.031). After additional adjustment for serum triglycerides, this inverse association persisted, but was somewhat attenuated (P for trend =0.050). In contrast, green tea consumption was not associated with ba-PWV.Conclusions:Coffee consumption was inversely associated with arterial stiffness independent of known atherosclerotic risk factors, and this association was partly mediated by reduced circulating triglycerides. Further prospective or interventional studies are needed to confirm the causal association.European Journal of Clinical Nutrition advance online publication, 17 July 2013; doi:10.1038/ejcn.2013.132.","ja":"Background/Objectives:Studies on the associations between coffee and green tea consumption and arterial stiffness are rare. This study evaluated the possible relationships between coffee and green tea consumption and brachial-ankle pulse wave velocity (ba-PWV) values in Japanese men.Subjects/Methods:In total, 540 eligible men who enrolled in the baseline survey of a cohort study in Tokushima Prefecture, Japan, and who underwent ba-PWV measurement were analyzed. Information about lifestyle characteristics including coffee and green tea intake were obtained from a structural self-administered questionnaire. Multiple linear regression analyses were used to evaluate the associations between coffee and green tea consumption and ba-PWV.Results:Subjects with greater coffee consumption were younger and showed higher proportions of current smoking and alcohol consumption. Subjects with greater green tea consumption were older and showed lower proportions of current smoking and alcohol consumption. Greater coffee consumption was significantly inversely associated with ba-PWV after the adjustment for probable covariates, including serum low-density lipoprotein cholesterol and high-density lipoprotein cholesterol (P for trend =0.031). After additional adjustment for serum triglycerides, this inverse association persisted, but was somewhat attenuated (P for trend =0.050). In contrast, green tea consumption was not associated with ba-PWV.Conclusions:Coffee consumption was inversely associated with arterial stiffness independent of known atherosclerotic risk factors, and this association was partly mediated by reduced circulating triglycerides. Further prospective or interventional studies are needed to confirm the causal association.European Journal of Clinical Nutrition advance online publication, 17 July 2013; doi:10.1038/ejcn.2013.132."},"publication_date":"2013-07-17","publication_name":{"en":"European Journal of Clinical Nutrition","ja":"European Journal of Clinical Nutrition"},"languages":["eng"],"referee":true,"identifiers":{"doi":["10.1038/ejcn.2013.132"],"issn":["1476-5640"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/23874065","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=273558","label":"url"}],"paper_title":{"en":"Polymorphisms in genes encoding antioxidant enzymes (SOD2, CAT, GPx, TXNRD, SEPP1, SEP15 and SELS) and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study","ja":"Polymorphisms in genes encoding antioxidant enzymes (SOD2, CAT, GPx, TXNRD, SEPP1, SEP15 and SELS) and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study"},"authors":{"en":[{"name":"Hishida A"},{"name":"Okada R"},{"name":"Naito M"},{"name":"Morita E"},{"name":"Wakai T"},{"name":"Hamajima N"},{"name":"Hosono S"},{"name":"Nanri H"},{"name":"Turin TC"},{"name":"Suzuki S"},{"name":"Kuwabara K"},{"name":"Mikami H"},{"name":"Budhathoki S"},{"name":"Watanabe I"},{"name":"Arisawa Kokichi"},{"name":"Kubo M"},{"name":"Tanaka H"}],"ja":[{"name":"Hishida A"},{"name":"Okada R"},{"name":"Naito M"},{"name":"Morita E"},{"name":"Wakai T"},{"name":"Hamajima N"},{"name":"Hosono S"},{"name":"Nanri H"},{"name":"Turin TC"},{"name":"Suzuki S"},{"name":"Kuwabara K"},{"name":"Mikami H"},{"name":"Budhathoki S"},{"name":"Watanabe I"},{"name":"有澤 孝吉"},{"name":"Kubo M"},{"name":"Tanaka H"}]},"description":{"en":"Chronic kidney disease (CKD) is well known as a strong risk factor for both of end-stage renal disease and cardiovascular disease. To clarify the association of polymorphisms in the genes encoding antioxidant enzymes (SOD2, CAT, GPx, TXNRD, SEPP1, SEP15 and SELS) with the risk of CKD in Japanese, we examined this association using the cross-sectional data of Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. The subjects were 3,285 men and women, aged 35-69 years, selected from J-MICC Study participants for whom genotyping were conducted by multiplex polymerase chain reaction-based Invader assay. The prevalence of CKD was determined for CKD stages 3-5 (eGFR <60 ml/min/1.73 m(2)). When those with CAT C-262T C/C were defined as reference, those with CAT C-262T C/T demonstrated the OR for CKD of 0.67 (95% CI 0.43-1.06) with the marginally significant trend for decreased odds ratio with increasing numbers of T allele (p = 0.070). There were no significant associations between the other polymorphisms with CKD risk. The present study found a marginally significant trend of the decreased risk of CKD with increasing numbers of T allele of CAT, which may suggest the possibility of personalized risk estimation of this life-limiting disease in the near future.","ja":"Chronic kidney disease (CKD) is well known as a strong risk factor for both of end-stage renal disease and cardiovascular disease. To clarify the association of polymorphisms in the genes encoding antioxidant enzymes (SOD2, CAT, GPx, TXNRD, SEPP1, SEP15 and SELS) with the risk of CKD in Japanese, we examined this association using the cross-sectional data of Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. The subjects were 3,285 men and women, aged 35-69 years, selected from J-MICC Study participants for whom genotyping were conducted by multiplex polymerase chain reaction-based Invader assay. The prevalence of CKD was determined for CKD stages 3-5 (eGFR <60 ml/min/1.73 m(2)). When those with CAT C-262T C/C were defined as reference, those with CAT C-262T C/T demonstrated the OR for CKD of 0.67 (95% CI 0.43-1.06) with the marginally significant trend for decreased odds ratio with increasing numbers of T allele (p = 0.070). There were no significant associations between the other polymorphisms with CKD risk. The present study found a marginally significant trend of the decreased risk of CKD with increasing numbers of T allele of CAT, which may suggest the possibility of personalized risk estimation of this life-limiting disease in the near future."},"publication_date":"2013-07","publication_name":{"en":"Journal of Clinical Biochemistry and Nutrition","ja":"Journal of Clinical Biochemistry and Nutrition"},"volume":"Vol.53","number":"No.1","starting_page":"15","ending_page":"20","languages":["eng"],"referee":true,"identifiers":{"doi":["10.3164/jcbn.13-17"],"issn":["1880-5086"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/105887","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/23574777","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=279320","label":"url"}],"paper_title":{"en":"Consumption of seafood, serum liver enzymes, and blood levels of PFOS and PFOA in the Japanese population.","ja":"Consumption of seafood, serum liver enzymes, and blood levels of PFOS and PFOA in the Japanese population."},"authors":{"en":[{"name":"Yamaguchi Miwa"},{"name":"Arisawa Kokichi"},{"name":"Uemura Hirokazu"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Takami Hidenobu"},{"name":"Sawachika Fusakazu"},{"name":"Nakamoto Mariko"},{"name":"Juta Tomoya"},{"name":"Toda Eisaku"},{"name":"Mori Kei"},{"name":"Hasegawa Manabu"},{"name":"Tanto Masaharu"},{"name":"Shima Masayuki"},{"name":"Sumiyoshi Yoshio"},{"name":"Morinaga Kenji"},{"name":"Kodama Kazunori"},{"name":"Suzuki Takaichiro"},{"name":"Nagai Masaki"},{"name":"Satoh Hiroshi"}],"ja":[{"name":"山口 美輪"},{"name":"有澤 孝吉"},{"name":"上村 浩一"},{"name":"勝浦-釜野 桜子"},{"name":"髙見 栄喜"},{"name":"澤近 房和"},{"name":"中本 真理子"},{"name":"十田 朋也"},{"name":"Toda Eisaku"},{"name":"Mori Kei"},{"name":"Hasegawa Manabu"},{"name":"Tanto Masaharu"},{"name":"Shima Masayuki"},{"name":"Sumiyoshi Yoshio"},{"name":"Morinaga Kenji"},{"name":"Kodama Kazunori"},{"name":"Suzuki Takaichiro"},{"name":"Nagai Masaki"},{"name":"Satoh Hiroshi"}]},"description":{"en":"Perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) have been shown to accumulate in the human body. The purpose of the present study was to examine the factors associated with the blood levels of PFOS and PFOA. A cross-sectional study was performed on 307 men and 301 women (aged 16-76 years) living in 15 prefectures in Japan. Blood levels of PFOS and PFOA were measured by liquid chromatography-mass spectrometry. Hepatic enzymes (-GTP, GOT, and GPT) and -3 polyunsaturated fatty acids (DHA and EPA) levels in serum were also measured. Associations between the levels of PFOS and PFOA in blood and the intake frequency of 41 kinds of dishes, foods and beverages and the serum levels of liver enzymes and -3 polyunsaturated fatty acids were examined using rank correlations. Frequency of intake of boiled fish in broth, sliced raw fish and coastal fish showed significant positive correlations with PFOS concentrations in blood after adjustments for potential confounders. Serum levels of GOT, GPT, DHA and EPA showed significant positive correlations with PFOS and PFOA in blood. There was also a significant regional difference in the blood levels of PFOS and 2013PFOA, with medians being highest in the Tokai/Hokuriku/Kinki region. These findings suggest that the concentrations of PFOS in blood were mainly associated with fish consumption and that the levels of PFOS and PFOA were associated with the serum levels of liver enzymes in Japanese populations. Further investigations are required to clarify the reason for the regional differences in blood levels of PFOS and PFOA in Japan.","ja":"Perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) have been shown to accumulate in the human body. The purpose of the present study was to examine the factors associated with the blood levels of PFOS and PFOA. A cross-sectional study was performed on 307 men and 301 women (aged 16-76 years) living in 15 prefectures in Japan. Blood levels of PFOS and PFOA were measured by liquid chromatography-mass spectrometry. Hepatic enzymes (-GTP, GOT, and GPT) and -3 polyunsaturated fatty acids (DHA and EPA) levels in serum were also measured. Associations between the levels of PFOS and PFOA in blood and the intake frequency of 41 kinds of dishes, foods and beverages and the serum levels of liver enzymes and -3 polyunsaturated fatty acids were examined using rank correlations. Frequency of intake of boiled fish in broth, sliced raw fish and coastal fish showed significant positive correlations with PFOS concentrations in blood after adjustments for potential confounders. Serum levels of GOT, GPT, DHA and EPA showed significant positive correlations with PFOS and PFOA in blood. There was also a significant regional difference in the blood levels of PFOS and 2013PFOA, with medians being highest in the Tokai/Hokuriku/Kinki region. These findings suggest that the concentrations of PFOS in blood were mainly associated with fish consumption and that the levels of PFOS and PFOA were associated with the serum levels of liver enzymes in Japanese populations. Further investigations are required to clarify the reason for the regional differences in blood levels of PFOS and PFOA in Japan."},"publication_date":"2013-04-09","publication_name":{"en":"Journal of Occupational Health","ja":"Journal of Occupational Health"},"volume":"Vol.55","number":"No.3","starting_page":"184","ending_page":"194","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1539/joh.12-0264-OA"],"issn":["1348-9585"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/23408455","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=260992","label":"url"}],"paper_title":{"en":"Genome-wide association study of the genetic factors related to confectionery intake: potential roles of the ADIPOQ gene","ja":"Genome-wide association study of the genetic factors related to confectionery intake: potential roles of the ADIPOQ gene"},"authors":{"en":[{"name":"Wakai K"},{"name":"Matsuo K"},{"name":"Matsuda F"},{"name":"Yamada R"},{"name":"Takahashi M"},{"name":"Kawaguchi T"},{"name":"Yatabe Y"},{"name":"Ito H"},{"name":"Hosono S"},{"name":"Tajima K"},{"name":"Naito M"},{"name":"Morita E"},{"name":"Yin G"},{"name":"Sakamoto T"},{"name":"Takashima N"},{"name":"Suzuki S"},{"name":"Nakahata N"},{"name":"Mikami H"},{"name":"Ohnaka K"},{"name":"Watanabe Y"},{"name":"Arisawa Kokichi"},{"name":"Kubo M"},{"name":"Hamajima N"},{"name":"Tanaka H"},{"name":"the J-MICC Study Group"}],"ja":[{"name":"Wakai K"},{"name":"Matsuo K"},{"name":"Matsuda F"},{"name":"Yamada R"},{"name":"Takahashi M"},{"name":"Kawaguchi T"},{"name":"Yatabe Y"},{"name":"Ito H"},{"name":"Hosono S"},{"name":"Tajima K"},{"name":"Naito M"},{"name":"Morita E"},{"name":"Yin G"},{"name":"Sakamoto T"},{"name":"Takashima N"},{"name":"Suzuki S"},{"name":"Nakahata N"},{"name":"Mikami H"},{"name":"Ohnaka K"},{"name":"Watanabe Y"},{"name":"有澤 孝吉"},{"name":"Kubo M"},{"name":"Hamajima N"},{"name":"Tanaka H"},{"name":"the J-MICC Study Group"}]},"description":{"en":"Objective: The excessive consumption of confectionery might have adverse effects on human health. To screen genetic factors associated with confectionery-intake frequency, a genome-wide association study (GWAS) in Japan was conducted. Design and Methods: For the discovery phase (stage 1), we conducted a GWAS of 939 noncancer patients in a cancer hospital. Additive models were used to test associations between genotypes of approximately 500,000 single-nucleotide polymorphisms (SNPs) and the confectionery-intake score (based on intake frequency). We followed-up association signals with P < 1 × 10(-5) and minor allele frequency >0.01 in stage 1 by genotyping the SNPs of 4,491 participants in a cross-sectional study within a cohort (replication phase [stage 2]). Results: We identified 12 SNPs in stage 1 that were potentially related to confectionery intake. In stage 2, this association was replicated for one SNP (rs822396; P = 0.049 for stage 2 and 4.2 × 10(-5) for stage 1+2) in intron 1 of the ADIPOQ gene, which encodes the adipokine adiponectin. Conclusions: Given the biological plausibility and previous relevant findings, the association of an SNP in the ADIPOQ gene with a preference for confectionery is worthy of follow-up and provides a good working hypothesis for experimental testing.","ja":"Objective: The excessive consumption of confectionery might have adverse effects on human health. To screen genetic factors associated with confectionery-intake frequency, a genome-wide association study (GWAS) in Japan was conducted. Design and Methods: For the discovery phase (stage 1), we conducted a GWAS of 939 noncancer patients in a cancer hospital. Additive models were used to test associations between genotypes of approximately 500,000 single-nucleotide polymorphisms (SNPs) and the confectionery-intake score (based on intake frequency). We followed-up association signals with P < 1 × 10(-5) and minor allele frequency >0.01 in stage 1 by genotyping the SNPs of 4,491 participants in a cross-sectional study within a cohort (replication phase [stage 2]). Results: We identified 12 SNPs in stage 1 that were potentially related to confectionery intake. In stage 2, this association was replicated for one SNP (rs822396; P = 0.049 for stage 2 and 4.2 × 10(-5) for stage 1+2) in intron 1 of the ADIPOQ gene, which encodes the adipokine adiponectin. Conclusions: Given the biological plausibility and previous relevant findings, the association of an SNP in the ADIPOQ gene with a preference for confectionery is worthy of follow-up and provides a good working hypothesis for experimental testing."},"publication_date":"2013-03","publication_name":{"en":"Obesity","ja":"Obesity"},"volume":"Vol.21","number":"No.11","starting_page":"2413","ending_page":"2419","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1002/oby.20316"],"issn":["1930-739X"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/23260717","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=260989","label":"url"}],"paper_title":{"en":"Human gastroenteritis outbreak associated with Escherichia albertii, Japan","ja":"Human gastroenteritis outbreak associated with Escherichia albertii, Japan"},"authors":{"en":[{"name":"Ooka T"},{"name":"Tokuoka E"},{"name":"Furukawa M"},{"name":"Nagamura T"},{"name":"Ogura Y"},{"name":"Arisawa Kokichi"},{"name":"Harada S"},{"name":"Hayashi T"}],"ja":[{"name":"Ooka T"},{"name":"Tokuoka E"},{"name":"Furukawa M"},{"name":"Nagamura T"},{"name":"Ogura Y"},{"name":"有澤 孝吉"},{"name":"Harada S"},{"name":"Hayashi T"}]},"description":{"en":"Although Escherichia albertii is an emerging intestinal pathogen, it has been associated only with sporadic human infections. In this study, we determined that a human gastroenteritis outbreak at a restaurant in Japan had E. albertii as the major causative agent.","ja":"Although Escherichia albertii is an emerging intestinal pathogen, it has been associated only with sporadic human infections. In this study, we determined that a human gastroenteritis outbreak at a restaurant in Japan had E. albertii as the major causative agent."},"publication_date":"2013-03","publication_name":{"en":"Emerging Infectious Diseases","ja":"Emerging Infectious Diseases"},"volume":"Vol.19","number":"No.1","starting_page":"144","ending_page":"146","languages":["eng"],"referee":true,"identifiers":{"doi":["10.3201/eid1901.120646"],"issn":["1080-6059"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/24288525","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-84888874108&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=340021","label":"url"}],"paper_title":{"en":"Polymorphisms in PPAR genes (PPARD, PPARG and PPARGC1A) and risk of chronic kidney disease in Japanese: cross-sectional data from the J-MICC Study","ja":"Polymorphisms in PPAR genes (PPARD, PPARG and PPARGC1A) and risk of chronic kidney disease in Japanese: cross-sectional data from the J-MICC Study"},"authors":{"en":[{"name":"Hishida A"},{"name":"Wakai K"},{"name":"Naito M"},{"name":"Tamura T"},{"name":"Kawai S"},{"name":"Hamajima N"},{"name":"Oze I"},{"name":"Imaizumu T"},{"name":"Turin T"},{"name":"Suzuki S"},{"name":"Kheradmand M"},{"name":"Mikami H"},{"name":"Ohnaka K"},{"name":"Watanabe Y"},{"name":"Arisawa Kokichi"},{"name":"Kubo M"},{"name":"Tanaka H"}],"ja":[{"name":"Hishida A"},{"name":"Wakai K"},{"name":"Naito M"},{"name":"Tamura T"},{"name":"Kawai S"},{"name":"Hamajima N"},{"name":"Oze I"},{"name":"Imaizumu T"},{"name":"Turin T"},{"name":"Suzuki S"},{"name":"Kheradmand M"},{"name":"Mikami H"},{"name":"Ohnaka K"},{"name":"Watanabe Y"},{"name":"有澤 孝吉"},{"name":"Kubo M"},{"name":"Tanaka H"}]},"description":{"en":"Chronic kidney disease (CKD) is well known as a strong risk factor for both end stage renal disease and cardiovascular disease. To clarify the association of polymorphisms in the PPAR genes (PPARD, PPARG, and PPARGC1A) with the risk of CKD in Japanese, we examined this association among the Japanese subjects using the cross-sectional data of J-MICC (Japan Multi-Institutional Collaborative Cohort) Study. The subjects for this analysis were 3,285 men and women, aged 35-69 years, selected from J-MICC Study participants; genotyping was conducted by multiplex polymerase chain reaction-based Invader assay. The prevalence of CKD was determined for CKD stages 3-5 (defined as eGFR < 60 ml/min/1.73 m(2)). Participants with CKD accounted for 17.3% of the study population. When those with PPARD T-842C T/T were defined as reference, those with PPARD T-842C T/C and C/C demonstrated the OR for CKD of 1.26 (95%CI 1.04-1.53) and 1.31 (95%CI 0.83-2.06), respectively. There were no significant associations between the polymorphisms in other PPAR genes and the risk of CKD. The present study found a significantly increased risk of CKD in those with the C allele of PPARD T-842C, which may suggest the possibility of personalized risk estimation of this life-limiting disease in the near future.","ja":"Chronic kidney disease (CKD) is well known as a strong risk factor for both end stage renal disease and cardiovascular disease. To clarify the association of polymorphisms in the PPAR genes (PPARD, PPARG, and PPARGC1A) with the risk of CKD in Japanese, we examined this association among the Japanese subjects using the cross-sectional data of J-MICC (Japan Multi-Institutional Collaborative Cohort) Study. The subjects for this analysis were 3,285 men and women, aged 35-69 years, selected from J-MICC Study participants; genotyping was conducted by multiplex polymerase chain reaction-based Invader assay. The prevalence of CKD was determined for CKD stages 3-5 (defined as eGFR < 60 ml/min/1.73 m(2)). Participants with CKD accounted for 17.3% of the study population. When those with PPARD T-842C T/T were defined as reference, those with PPARD T-842C T/C and C/C demonstrated the OR for CKD of 1.26 (95%CI 1.04-1.53) and 1.31 (95%CI 0.83-2.06), respectively. There were no significant associations between the polymorphisms in other PPAR genes and the risk of CKD. The present study found a significantly increased risk of CKD in those with the C allele of PPARD T-842C, which may suggest the possibility of personalized risk estimation of this life-limiting disease in the near future."},"publication_date":"2013-01-01","publication_name":{"en":"PPAR Research","ja":"PPAR Research"},"volume":"Vol.2013","starting_page":"980471","ending_page":"980471","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1155/2013/980471"],"issn":["1687-4757"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/23047663","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=248929","label":"url"}],"paper_title":{"en":"Inverse Correlation between Coffee Consumption and Prevalence of Metabolic Syndrome: Baseline Survey of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study in Tokushima, Japan","ja":"Inverse Correlation between Coffee Consumption and Prevalence of Metabolic Syndrome: Baseline Survey of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study in Tokushima, Japan"},"authors":{"en":[{"name":"Takami Hidenobu"},{"name":"Nakamoto Mariko"},{"name":"Uemura Hirokazu"},{"name":"Katsuura Sakurako"},{"name":"Yamaguchi Miwa"},{"name":"Hiyoshi Mineyoshi"},{"name":"Sawachika Fusakazu"},{"name":"Juta Tomoya"},{"name":"Arisawa Kokichi"}],"ja":[{"name":"髙見 栄喜"},{"name":"中本 真理子"},{"name":"上村 浩一"},{"name":"勝浦 桜子"},{"name":"山口 美輪"},{"name":"Hiyoshi Mineyoshi"},{"name":"澤近 房和"},{"name":"十田 朋也"},{"name":"有澤 孝吉"}]},"description":{"en":"It is unclear whether consumption of coffee and green tea is associated with metabolic syndrome. This cross-sectional study enrolled 554 adults who had participated in the baseline survey of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study in Tokushima Prefecture, Japan. Consumption of coffee and green tea was assessed using a questionnaire. Metabolic syndrome was diagnosed using the criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) and the Japan Society for the Study of Obesity (JASSO). Logistic regression analysis was used to examine the association between consumption of coffee and green tea and prevalence of metabolic syndrome and its components. After adjustment for sex, age, and other potential confounders, greater coffee consumption was associated with a significantly lower prevalence of metabolic syndrome, as defined by NCEP ATP III criteria (P for trend = 0.03). Participants who drank more coffee had a lower odds ratio (OR) for high serum triglycerides (P for trend = 0.02), but not for increased waist circumference or high blood pressure. Using JASSO criteria, moderate coffee consumption (1.5 to <3 cups/day) was associated with a significantly lower OR for high plasma glucose (OR = 0.51, 95% CI 0.28-0.93). Green tea consumption was not associated with the prevalence of metabolic syndrome or any of its components. Coffee consumption was inversely correlated with metabolic syndrome diagnosed using NCEP ATP III criteria, mainly because it was associated with lower serum triglyceride levels. This association highlights the need for further prospective studies of the causality of these relationships.","ja":"It is unclear whether consumption of coffee and green tea is associated with metabolic syndrome. This cross-sectional study enrolled 554 adults who had participated in the baseline survey of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study in Tokushima Prefecture, Japan. Consumption of coffee and green tea was assessed using a questionnaire. Metabolic syndrome was diagnosed using the criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) and the Japan Society for the Study of Obesity (JASSO). Logistic regression analysis was used to examine the association between consumption of coffee and green tea and prevalence of metabolic syndrome and its components. After adjustment for sex, age, and other potential confounders, greater coffee consumption was associated with a significantly lower prevalence of metabolic syndrome, as defined by NCEP ATP III criteria (P for trend = 0.03). Participants who drank more coffee had a lower odds ratio (OR) for high serum triglycerides (P for trend = 0.02), but not for increased waist circumference or high blood pressure. Using JASSO criteria, moderate coffee consumption (1.5 to <3 cups/day) was associated with a significantly lower OR for high plasma glucose (OR = 0.51, 95% CI 0.28-0.93). Green tea consumption was not associated with the prevalence of metabolic syndrome or any of its components. Coffee consumption was inversely correlated with metabolic syndrome diagnosed using NCEP ATP III criteria, mainly because it was associated with lower serum triglyceride levels. This association highlights the need for further prospective studies of the causality of these relationships."},"publication_date":"2013-01","publication_name":{"en":"Journal of Epidemiology","ja":"Journal of Epidemiology"},"volume":"Vol.23","number":"No.1","starting_page":"12","ending_page":"20","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2188/jea.JE20120053"],"issn":["1349-9092"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=304027","label":"url"}],"paper_title":{"en":"Diagnostic spectrum of multifocal motor neuropathy","ja":"Diagnostic spectrum of multifocal motor neuropathy"},"authors":{"en":[{"name":"Matsui Naoko"},{"name":"Miyashiro Ai"},{"name":"Shimatani Yoshimitsu"},{"name":"Nodera Hiroyuki"},{"name":"Izumi Yuishin"},{"name":"Kuwabara Satoshi"},{"name":"Baba Masayuki"},{"name":"Komori Tetsuo"},{"name":"Sonoo Masahiro"},{"name":"Mezaki Takahiro"},{"name":"Kawamata Jun"},{"name":"Hitomi Takefumi"},{"name":"Imai Tomihiro"},{"name":"Kohara Nobuo"},{"name":"Arimura Kimiyoshi"},{"name":"Arisawa Kokichi"},{"name":"Kusunoki Susumu"},{"name":"Kaji Ryuji"}],"ja":[{"name":"松井 尚子"},{"name":"宮城 愛"},{"name":"島谷 佳光"},{"name":"野寺 裕之"},{"name":"和泉 唯信"},{"name":"Kuwabara Satoshi"},{"name":"Baba Masayuki"},{"name":"Komori Tetsuo"},{"name":"Sonoo Masahiro"},{"name":"Mezaki Takahiro"},{"name":"Kawamata Jun"},{"name":"Hitomi Takefumi"},{"name":"Imai Tomihiro"},{"name":"Kohara Nobuo"},{"name":"Arimura Kimiyoshi"},{"name":"有澤 孝吉"},{"name":"Kusunoki Susumu"},{"name":"梶 龍兒"}]},"publication_date":"2013","publication_name":{"en":"Clinical & Experimental Neuroimmunology","ja":"Clinical & Experimental Neuroimmunology"},"volume":"Vol.4","number":"No.2","starting_page":"210","ending_page":"215","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1111/cen3.12025"],"issn":["1759-1961"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/23945417","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-84883773457&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=268738","label":"url"}],"paper_title":{"en":"Relationship of dietary factors and habits with sleep-wake regularity.","ja":"Relationship of dietary factors and habits with sleep-wake regularity."},"authors":{"en":[{"name":"Yamaguchi Miwa"},{"name":"Uemura Hirokazu"},{"name":"Katsuura-Kamano Sakurako"},{"name":"Nakamoto Mariko"},{"name":"Hiyoshi Mineyoshi"},{"name":"Takami Hidenobu"},{"name":"Sawachika Fusakazu"},{"name":"Juta Tomoya"},{"name":"Arisawa Kokichi"}],"ja":[{"name":"山口 美輪"},{"name":"上村 浩一"},{"name":"勝浦-釜野 桜子"},{"name":"中本 真理子"},{"name":"Hiyoshi Mineyoshi"},{"name":"髙見 栄喜"},{"name":"澤近 房和"},{"name":"十田 朋也"},{"name":"有澤 孝吉"}]},"description":{"en":"The purpose of this study was to evaluate the associations between dietary factors and sleep-wake regularity in the Japanese population. We analyzed 1368 eligible subjects (931 men and 437 women) aged 35-69 years who had participated in the baseline survey of a cohort study in Tokushima Prefecture, Japan. Information on individual lifestyle characteristics, including dietary habits and sleep-wake regularity, was obtained by a selfadministrated questionnaire. Logistic regression analyses were performed to evaluate adjusted associations of the intake energy ratios of macronutrients, as well as intake frequency, and the amount of staple foods with sleepwake regularity. The lowest quartile of protein intake as well as the highest quartile of carbohydrates showed significantly higher multivariable-adjusted odds ratios of 2.1 (95% confidence interval, 1.3-3.3) and 2.1 (1.3-3.5), respectively, for poor sleep-wake regularity compared with the respective second quartile that is thought to be moderate intake. Regarding intake of staple foods, low weekly intake frequency at breakfast (<5 times/week), the lowest intake amount (<1 bowl or slice/roll) at breakfast, and the highest intake amount (>=2 bowls or slices/ rolls) at lunch and dinner exhibited significantly high adjusted odds ratios for poor sleep-wake regularity. Additionally adjusting for sleep duration, these results did not substantially alter. Our results suggested that low intake energy ratio of proteins and high intake energy ratio of carbohydrates, skipping intake of the staple foods at breakfast, and excessive intake amount of the staple foods at lunch and dinner may be associated with poor sleep-wake regularity.","ja":"The purpose of this study was to evaluate the associations between dietary factors and sleep-wake regularity in the Japanese population. We analyzed 1368 eligible subjects (931 men and 437 women) aged 35-69 years who had participated in the baseline survey of a cohort study in Tokushima Prefecture, Japan. Information on individual lifestyle characteristics, including dietary habits and sleep-wake regularity, was obtained by a selfadministrated questionnaire. Logistic regression analyses were performed to evaluate adjusted associations of the intake energy ratios of macronutrients, as well as intake frequency, and the amount of staple foods with sleepwake regularity. The lowest quartile of protein intake as well as the highest quartile of carbohydrates showed significantly higher multivariable-adjusted odds ratios of 2.1 (95% confidence interval, 1.3-3.3) and 2.1 (1.3-3.5), respectively, for poor sleep-wake regularity compared with the respective second quartile that is thought to be moderate intake. Regarding intake of staple foods, low weekly intake frequency at breakfast (<5 times/week), the lowest intake amount (<1 bowl or slice/roll) at breakfast, and the highest intake amount (>=2 bowls or slices/ rolls) at lunch and dinner exhibited significantly high adjusted odds ratios for poor sleep-wake regularity. Additionally adjusting for sleep duration, these results did not substantially alter. Our results suggested that low intake energy ratio of proteins and high intake energy ratio of carbohydrates, skipping intake of the staple foods at breakfast, and excessive intake amount of the staple foods at lunch and dinner may be associated with poor sleep-wake regularity."},"publication_date":"2013","publication_name":{"en":"Asia Pacific Journal of Clinical Nutrition","ja":"Asia Pacific Journal of Clinical Nutrition"},"volume":"Vol.22","number":"No.3","starting_page":"457","ending_page":"465","languages":["eng"],"referee":true,"identifiers":{"doi":["10.6133/apjcn.2013.22.3.01"],"issn":["0964-7058"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/23122449","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=260991","label":"url"}],"paper_title":{"en":"eNOS genotype modifies the effect of leisure-time physical activity on serum triglyceride levels in a Japanese population","ja":"eNOS genotype modifies the effect of leisure-time physical activity on serum triglyceride levels in a Japanese population"},"authors":{"en":[{"name":"Higashibata T"},{"name":"Hamajima N"},{"name":"Naito M"},{"name":"Kawai S"},{"name":"Yin G"},{"name":"Suzuki S"},{"name":"Kita Y"},{"name":"Niimura H"},{"name":"Imaizumi T"},{"name":"Ohnaka K"},{"name":"Arisawa Kokichi"},{"name":"Shigeta M"},{"name":"Ito H"},{"name":"Mikami H"},{"name":"Kubo M"},{"name":"Tanaka H"},{"name":"Wakai K"}],"ja":[{"name":"Higashibata T"},{"name":"Hamajima N"},{"name":"Naito M"},{"name":"Kawai S"},{"name":"Yin G"},{"name":"Suzuki S"},{"name":"Kita Y"},{"name":"Niimura H"},{"name":"Imaizumi T"},{"name":"Ohnaka K"},{"name":"有澤 孝吉"},{"name":"Shigeta M"},{"name":"Ito H"},{"name":"Mikami H"},{"name":"Kubo M"},{"name":"Tanaka H"},{"name":"Wakai K"}]},"description":{"en":"Nitric oxide is a key molecule not only in the cardiovascular system, but also in the metabolic-endocrine system. The purpose of this study was to examine possible associations of the NOS3 T-786C polymorphism (rs2070744) with serum lipid levels on the basis of lifestyle factors for tailoring prevention of dyslipidemia. For this cross-sectional study, a total of 2226 subjects aged 35 to 69 years (1084 men and 1142 women) were selected from Japanese participants in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. They were recruited in eight areas throughout Japan between February 2004 and November 2008. In a stratified analysis by leisure-time physical activity, the likelihood of hypertriglyceridemia (serum triglyceride levels ≥ 150 mg/dL) among subjects with the C allele was significantly lower than those without it in the active group (OR = 0.43, 95% CI = 0.22-0.84 in the fasting group), but not in the sedentary group. A gene-environment interaction between the T-786C polymorphism and leisure-time physical activity for hypertriglyceridemia was significant (P = 0.007 in the fasting group). Additionally, serum triglyceride levels (mean ± SD) across leisure-time physical activity classes decreased significantly only in the TC + CC genotype group (111 ± 60 mg/dL for sedentary, 95 ± 48 mg/dL for moderately active, 88 ± 44 mg/dL for very active, P for trend = 0.008 in the fasting group), but not in the TT genotype group. Total cholesterol, high-density lipoprotein (HDL) cholesterol, and non-HDL cholesterol levels had no significant association with the polymorphism. This study suggests that the NOS3 T-786C polymorphism modifies the effect of leisure-time physical activity on serum triglyceride levels.","ja":"Nitric oxide is a key molecule not only in the cardiovascular system, but also in the metabolic-endocrine system. The purpose of this study was to examine possible associations of the NOS3 T-786C polymorphism (rs2070744) with serum lipid levels on the basis of lifestyle factors for tailoring prevention of dyslipidemia. For this cross-sectional study, a total of 2226 subjects aged 35 to 69 years (1084 men and 1142 women) were selected from Japanese participants in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. They were recruited in eight areas throughout Japan between February 2004 and November 2008. In a stratified analysis by leisure-time physical activity, the likelihood of hypertriglyceridemia (serum triglyceride levels ≥ 150 mg/dL) among subjects with the C allele was significantly lower than those without it in the active group (OR = 0.43, 95% CI = 0.22-0.84 in the fasting group), but not in the sedentary group. A gene-environment interaction between the T-786C polymorphism and leisure-time physical activity for hypertriglyceridemia was significant (P = 0.007 in the fasting group). Additionally, serum triglyceride levels (mean ± SD) across leisure-time physical activity classes decreased significantly only in the TC + CC genotype group (111 ± 60 mg/dL for sedentary, 95 ± 48 mg/dL for moderately active, 88 ± 44 mg/dL for very active, P for trend = 0.008 in the fasting group), but not in the TT genotype group. Total cholesterol, high-density lipoprotein (HDL) cholesterol, and non-HDL cholesterol levels had no significant association with the polymorphism. This study suggests that the NOS3 T-786C polymorphism modifies the effect of leisure-time physical activity on serum triglyceride levels."},"publication_date":"2012-12","publication_name":{"en":"Lipids in Health and Disease","ja":"Lipids in Health and Disease"},"volume":"Vol.11","starting_page":"150","ending_page":"150","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1186/1476-511X-11-150"],"issn":["1476-511X"]},"published_paper_type":"scientific_journal"},"priority":"input_data"} {"insert":{"type":"published_papers"},"similar_merge":{"see_also":[{"@id":"http://id.ndl.go.jp/bib/024222598","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1390001204908494592/","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-84873382013&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=266143","label":"url"}],"paper_title":{"en":"Evaluation of the Sugar Content in the Side Dishes Served in Elementary School Lunches","ja":"小学校給食の副食に含まれる糖質量の検討"},"authors":{"en":[{"name":"Yamaguchi Miwa"},{"name":"Kuroda Akio"},{"name":"Kotani Yumiko"},{"name":"Matsumura Akiko"},{"name":"Kamano Sakurako"},{"name":"Uemura Hirokazu"},{"name":"Yokota Ichiro"},{"name":"Kagami Shoji"},{"name":"Arisawa Kokichi"},{"name":"Matsuhisa Munehide"}],"ja":[{"name":"山口 美輪"},{"name":"黒田 暁生"},{"name":"小谷 裕美子"},{"name":"松村 晃子"},{"name":"釜野 桜子"},{"name":"上村 浩一"},{"name":"横田 一郎"},{"name":"香美 祥二"},{"name":"有澤 孝吉"},{"name":"松久 宗英"}]},"description":{"en":"Kuroda et al. proposed a simple method for calculating the carbohydrate content based on a food exchange list (Shokuhin Koukanhyou), with a sugar content of dietary staples of 40 % for rice, 50 % for bread, and 20 % for boiled noodles and a side dish containing 20 g sugar. This study focused on the sugar content in in school lunches, which have a nutrient composition that is different from diabetic meals. The total energy content of school lunches and the sugar content in their side dishes were investigated in 42 school lunches served in elementary school. The average energy intake in the total lunch increased depending on the school grade (670±44 to 752±50 kcal; means±standard deviation). On the other hand, the sugar content of side dishes increased from 29.7±7.5 g in the 1st-2nd grade to 31.2±8.1 g in the 5th-6th grade, thus it could be estimated to be 30 g regardless of the energy intake. Two hundred milliliters of milk containing approximately 10 g of carbohydrate was served in every school lunch, which accounted for the 10 g increase in comparison to hospital lunches. These results indicate that the sugar content in the side dishes of elementary school lunches can be estimated to be 30 g regardless of the energy intake.