{"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=404094","label":"url"}],"paper_title":{"en":"線維化と腫瘍随伴リンパ組織増生を伴う粘表皮癌の1例","ja":"線維化と腫瘍随伴リンパ組織増生を伴う粘表皮癌の1例"},"authors":{"en":[{"name":"富田 満"},{"name":"Ogawa Hirohisa"},{"name":"Tsunematsu Takaaki"},{"name":"Sato Mami"},{"name":"山下 貴央"},{"name":"Kitamura Yoshiaki"},{"name":"Ishimaru Naozumi"},{"name":"Tsuneyama Koichi"},{"name":"Uehara Hisanori"},{"name":"Bando Yoshimi"}],"ja":[{"name":"富田 満"},{"name":"小川 博久"},{"name":"常松 貴明"},{"name":"佐藤 真美"},{"name":"山下 貴央"},{"name":"北村 嘉章"},{"name":"石丸 直澄"},{"name":"常山 幸一"},{"name":"上原 久典"},{"name":"坂東 良美"}]},"publication_date":"2023-10","publication_name":{"en":"診断病理","ja":"診断病理"},"volume":"Vol.40","number":"No.4","starting_page":"336","ending_page":"341","languages":["jpn"],"referee":true,"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://cir.nii.ac.jp/crid/1390577199128886400/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=395908","label":"url"}],"paper_title":{"en":"A Case of Downbeat Nystagmus Induced by Carbamazepine Intoxication","ja":"カルバマゼピン中毒により下眼瞼向き眼振を認めた薬剤性めまい症例"},"authors":{"en":[{"name":"Matsuda Kazunori"},{"name":"Satou Gou"},{"name":"Fukuda Junya"},{"name":"Takaoka Sho"},{"name":"Tomura Miki"},{"name":"Matsuoka Momoyo"},{"name":"Azuma Takahiro"},{"name":"Kitamura Yoshiaki"},{"name":"Imai Takao"},{"name":"Takeda Noriaki"}],"ja":[{"name":"松田 和徳"},{"name":"佐藤 豪"},{"name":"福田 潤弥"},{"name":"高岡 奨"},{"name":"戸村 美紀"},{"name":"松岡 百百世"},{"name":"東 貴弘"},{"name":"北村 嘉章"},{"name":"今井 貴夫"},{"name":"武田 憲昭"}]},"publication_date":"2023-02-28","publication_name":{"en":"Equilibrium Research","ja":"Equilibrium Research"},"volume":"Vol.82","number":"No.1","starting_page":"26","ending_page":"33","languages":["jpn"],"referee":true,"identifiers":{"doi":["10.3757/jser.82.26"],"issn":["0385-5716"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/118240","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/37164712","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=396759","label":"url"}],"paper_title":{"en":"Risk factors of first bite syndrome after surgical resection of parapharyngeal space tumors.","ja":"Risk factors of first bite syndrome after surgical resection of parapharyngeal space tumors."},"authors":{"en":[{"name":"Abe Koji"},{"name":"Uno Atsuhiko"},{"name":"Tamura Koichi"},{"name":"Kanamura Ryo"},{"name":"Ohnishi Hiroki"},{"name":"Ishitani Yuhki"},{"name":"Kondou Eiji"},{"name":"Azuma Takahiro"},{"name":"Satou Gou"},{"name":"Kitamura Yoshiaki"},{"name":"Takeda Noriaki"}],"ja":[{"name":"阿部 晃治"},{"name":"Uno Atsuhiko"},{"name":"田村 公一"},{"name":"金村 亮"},{"name":"大西 皓貴"},{"name":"Ishitani Yuhki"},{"name":"近藤 英司"},{"name":"東 貴弘"},{"name":"佐藤 豪"},{"name":"北村 嘉章"},{"name":"武田 憲昭"}]},"description":{"en":"The present findings suggest that concomitant surgical settings of 1) sympathetic denervation of the parotid gland with ligation of the external carotid artery or injury of the sympathetic nerve plexus around the external carotid artery during its mobilization, and 2) residual parotid gland tissue are risk factors for the development of first bite syndrome after surgical resection of parapharyngeal space tumors. J. Med. Invest. 70 : 150-153, February, 2023.","ja":"The present findings suggest that concomitant surgical settings of 1) sympathetic denervation of the parotid gland with ligation of the external carotid artery or injury of the sympathetic nerve plexus around the external carotid artery during its mobilization, and 2) residual parotid gland tissue are risk factors for the development of first bite syndrome after surgical resection of parapharyngeal space tumors. J. Med. Invest. 70 : 150-153, February, 2023."},"publication_date":"2023-02","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.70","number":"No.1.2","starting_page":"150","ending_page":"153","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.70.150"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/118202","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/36657901","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=395889","label":"url"}],"paper_title":{"en":"Muscle mass, quality, and strength; physical function and activity; and metabolic status in cachectic patients with head and neck cancer.","ja":"Muscle mass, quality, and strength; physical function and activity; and metabolic status in cachectic patients with head and neck cancer."},"authors":{"en":[{"name":"Omae Nao"},{"name":"Yasui-Yamada Sonoko"},{"name":"Furumoto Taiki"},{"name":"Wada Kyoko"},{"name":"Hayashi Haruka"},{"name":"Kitao Midori"},{"name":"Ayaka YAMANAKA"},{"name":"Kubo Miyu"},{"name":"Matsuoka Momoyo"},{"name":"Kamimura Seiichiro"},{"name":"Shimada Aki"},{"name":"Sato Nori"},{"name":"Kitamura Yoshiaki"},{"name":"Katoh Shinsuke"},{"name":"Takeda Noriaki"},{"name":"Hamada Yasuhiro"}],"ja":[{"name":"大前 奈央"},{"name":"山田 苑子"},{"name":"古本 太希"},{"name":"和田 京子"},{"name":"林 遼"},{"name":"北尾 緑"},{"name":"山中 彩夏"},{"name":"久保 みゆ"},{"name":"松岡 百百世"},{"name":"神村 盛一郎"},{"name":"島田 亜紀"},{"name":"佐藤 紀"},{"name":"北村 嘉章"},{"name":"加藤 真介"},{"name":"武田 憲昭"},{"name":"濵田 康弘"}]},"description":{"en":"Cancer cachexia is commonly associated with poor prognosis in patients with head and neck cancer (HNC). However, its pathophysiology and treatment are not well established. The current study aimed to assess the muscle mass/quality/strength, physical function and activity, resting energy expenditure (REE), and respiratory quotient (RQ) in cachectic patients with HNC. This prospective cross-sectional study analyzed 64 patients with HNC. Body composition was measured via direct segmental multifrequency bioelectrical impedance analysis, and muscle quality was assessed using echo intensity on ultrasonography images. Muscle strength was investigated utilizing handgrip strength and isometric knee extension force (IKEF). Physical function was evaluated using the 10-m walking speed test and the five times sit-to-stand (5-STS) test. Physical activity was examined using a wearable triaxial accelerometer. REE and RQ were measured via indirect calorimetry. These parameters were compared between the cachectic and noncachectic groups. In total, 23 (36%) patients were diagnosed with cachexia. The cachectic group had a significantly lower muscle mass than the noncachectic group. Nevertheless, there was no significant difference in terms of fat between the two groups. The cachectic group had a higher quadriceps echo intensity and a lower handgrip strength and IKEF than the noncachectic group. Moreover, they had a significantly slower normal and maximum walking speed and 5-STS speed. The number of steps, total activity time, and time of activity (<3 Mets) did not significantly differ between the two groups. The cachectic group had a shorter time of activity (≥3 Mets) than the noncachectic group. Furthermore, the cachectic group had a significantly higher REE/body weight and REE/fat free mass and a significantly lower RQ than the noncachectic group. The cachectic group had a lower muscle mass/quality/strength and physical function and activity and a higher REE than the noncachectic group. Thus, REE and physical activity should be evaluated to determine energy requirements. The RQ was lower in the cachectic group than that in the noncachectic group, indicating changes in energy substrate. Further studies must be conducted to examine effective nutritional and exercise interventions for patients with cancer cachexia.","ja":"Cancer cachexia is commonly associated with poor prognosis in patients with head and neck cancer (HNC). However, its pathophysiology and treatment are not well established. The current study aimed to assess the muscle mass/quality/strength, physical function and activity, resting energy expenditure (REE), and respiratory quotient (RQ) in cachectic patients with HNC. This prospective cross-sectional study analyzed 64 patients with HNC. Body composition was measured via direct segmental multifrequency bioelectrical impedance analysis, and muscle quality was assessed using echo intensity on ultrasonography images. Muscle strength was investigated utilizing handgrip strength and isometric knee extension force (IKEF). Physical function was evaluated using the 10-m walking speed test and the five times sit-to-stand (5-STS) test. Physical activity was examined using a wearable triaxial accelerometer. REE and RQ were measured via indirect calorimetry. These parameters were compared between the cachectic and noncachectic groups. In total, 23 (36%) patients were diagnosed with cachexia. The cachectic group had a significantly lower muscle mass than the noncachectic group. Nevertheless, there was no significant difference in terms of fat between the two groups. The cachectic group had a higher quadriceps echo intensity and a lower handgrip strength and IKEF than the noncachectic group. Moreover, they had a significantly slower normal and maximum walking speed and 5-STS speed. The number of steps, total activity time, and time of activity (<3 Mets) did not significantly differ between the two groups. The cachectic group had a shorter time of activity (≥3 Mets) than the noncachectic group. Furthermore, the cachectic group had a significantly higher REE/body weight and REE/fat free mass and a significantly lower RQ than the noncachectic group. The cachectic group had a lower muscle mass/quality/strength and physical function and activity and a higher REE than the noncachectic group. Thus, REE and physical activity should be evaluated to determine energy requirements. The RQ was lower in the cachectic group than that in the noncachectic group, indicating changes in energy substrate. Further studies must be conducted to examine effective nutritional and exercise interventions for patients with cancer cachexia."},"publication_date":"2023-02","publication_name":{"en":"Clinical Nutrition ESPEN","ja":"Clinical Nutrition ESPEN"},"volume":"Vol.53","starting_page":"113","ending_page":"119","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.clnesp.2022.12.006"],"issn":["2405-4577"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/118365","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/37164740","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=396760","label":"url"}],"paper_title":{"en":"Repetitive postoperative extubation failure due to dynamic inspiratory airway collapse concomitant with subglottic stenosis in a patient who previously underwent tracheostomy.","ja":"Repetitive postoperative extubation failure due to dynamic inspiratory airway collapse concomitant with subglottic stenosis in a patient who previously underwent tracheostomy."},"authors":{"en":[{"name":"Nakano Yuki"},{"name":"Ueno Yoshitoyo"},{"name":"Ishitani Emi"},{"name":"Sato Koji"},{"name":"Sato Hiroki"},{"name":"Momota Kazuki"},{"name":"Bando Natsuki"},{"name":"Akimoto Yusuke"},{"name":"Nunomura Toshiyuki"},{"name":"Ishihara Manabu"},{"name":"Tane Natsuki"},{"name":"Itagaki Taiga"},{"name":"Kitamura Yoshiaki"},{"name":"Oto Jun"}],"ja":[{"name":"Nakano Yuki"},{"name":"Ueno Yoshitoyo"},{"name":"Ishitani Emi"},{"name":"Sato Koji"},{"name":"Sato Hiroki"},{"name":"Momota Kazuki"},{"name":"Bando Natsuki"},{"name":"Akimoto Yusuke"},{"name":"Nunomura Toshiyuki"},{"name":"Ishihara Manabu"},{"name":"Tane Natsuki"},{"name":"Itagaki Taiga"},{"name":"北村 嘉章"},{"name":"Oto Jun"}]},"description":{"en":"We should be aware of the history of tracheostomy, especially at high tracheostomy sites, even in the absence of respiratory symptoms as risk factors for dynamic inspiratory airway collapse concomitant with subglottic stenosis contributing to repeated respiratory failure after extubation. J. Med. Invest. 70 : 301-305, February, 2023.","ja":"We should be aware of the history of tracheostomy, especially at high tracheostomy sites, even in the absence of respiratory symptoms as risk factors for dynamic inspiratory airway collapse concomitant with subglottic stenosis contributing to repeated respiratory failure after extubation. J. Med. Invest. 70 : 301-305, February, 2023."},"publication_date":"2023","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.70","number":"No.1.2","starting_page":"301","ending_page":"305","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.70.301"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/118239","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/36425390","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85142414132&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=397194","label":"url"}],"paper_title":{"en":"Imaging features of a myoepithelial carcinoma of the nasal cavity: A case report and literature review","ja":"Imaging features of a myoepithelial carcinoma of the nasal cavity: A case report and literature review"},"authors":{"en":[{"name":"Shinya Takayoshi"},{"name":"MATSUSHITA Tomoki"},{"name":"HIROSHIMA Yuka"},{"name":"Otomi Youichi"},{"name":"Kanematsu Yasuhisa"},{"name":"Bando Yoshimi"},{"name":"Uehara Hisanori"},{"name":"Kitamura Yoshiaki"},{"name":"Harada Masafumi"}],"ja":[{"name":"新家 崇義"},{"name":"松下 知樹"},{"name":"廣島 由"},{"name":"音見 暢一"},{"name":"兼松 康久"},{"name":"坂東 良美"},{"name":"上原 久典"},{"name":"北村 嘉章"},{"name":"原田 雅史"}]},"description":{"en":"Myoepithelial carcinoma of the nasal cavity is extremely rare. We report the case of a 66-year-old man with myoepithelial carcinoma of the nasal cavity. Computed tomography (CT) and magnetic resonance imaging revealed a lobulated soft tissue mass with central necrosis and hemorrhage, as well as an invasion of the skull base and left orbit. The patient presented with continuous nasal congestion and heavy head and had no elevated level of squamous cell carcinoma-related antigen. CT, magnetic resonance imaging, or F-fluorodeoxyglucose (FDG) positron emission tomography/CT revealed no evidence of a metastatic lesion. F-FDG accumulation in the tumor was inhomogeneous and moderate. Histopathological examination of the resected specimen confirmed a well-circumscribed solid tumor with septa, a small area of hemorrhage, and necrosis. The subsequent diagnosis was a myoepithelial carcinoma of the left nasal cavity. This case shows that nasal myoepithelial carcinoma might appear as a well-defined lobulated mass with hemorrhagic necrosis and intense contrast enhancement in the solid component. We conjecture that hemorrhagic necrosis and intense enhancement values may be potential markers of nasal myoepithelial carcinoma.","ja":"Myoepithelial carcinoma of the nasal cavity is extremely rare. We report the case of a 66-year-old man with myoepithelial carcinoma of the nasal cavity. Computed tomography (CT) and magnetic resonance imaging revealed a lobulated soft tissue mass with central necrosis and hemorrhage, as well as an invasion of the skull base and left orbit. The patient presented with continuous nasal congestion and heavy head and had no elevated level of squamous cell carcinoma-related antigen. CT, magnetic resonance imaging, or F-fluorodeoxyglucose (FDG) positron emission tomography/CT revealed no evidence of a metastatic lesion. F-FDG accumulation in the tumor was inhomogeneous and moderate. Histopathological examination of the resected specimen confirmed a well-circumscribed solid tumor with septa, a small area of hemorrhage, and necrosis. The subsequent diagnosis was a myoepithelial carcinoma of the left nasal cavity. This case shows that nasal myoepithelial carcinoma might appear as a well-defined lobulated mass with hemorrhagic necrosis and intense contrast enhancement in the solid component. We conjecture that hemorrhagic necrosis and intense enhancement values may be potential markers of nasal myoepithelial carcinoma."},"publication_date":"2022-11-18","publication_name":{"en":"Radiology Case Reports","ja":"Radiology Case Reports"},"volume":"Vol.18","number":"No.1","starting_page":"386","ending_page":"391","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.radcr.2022.10.081"],"issn":["1930-0433"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/117847","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/36080225","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85137579924&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=391803","label":"url"}],"paper_title":{"en":"Betuletol, a propolis component, suppresses IL-33 gene expression and effective against eosinophilia","ja":"Betuletol, a propolis component, suppresses IL-33 gene expression and effective against eosinophilia"},"authors":{"en":[{"name":"Aurpita Shaha"},{"name":"Rezwanul Islam"},{"name":"Tanaka Naonobu"},{"name":"Kashiwada Yoshiki"},{"name":"Fukui Hiroyuki"},{"name":"Takeda Noriaki"},{"name":"Kitamura Yoshiaki"},{"name":"Mizuguchi Hiroyuki"}],"ja":[{"name":"Aurpita Shaha"},{"name":"Rezwanul Islam"},{"name":"田中 直伸"},{"name":"柏田 良樹"},{"name":"福井 裕行"},{"name":"武田 憲昭"},{"name":"北村 嘉章"},{"name":"水口 博之"}]},"description":{"en":"Propolis, a resinous substance produced by honeybees, has been used in folk medicine since ancient times due to its many biological benefits such as antitumor, antioxidant, antimicrobial, anti-inflammatory, and immunomodulatory effects. Propolis contains flavonoids, terpenoids, aromatic aldehydes, and alcohols, which vary with different climate and environmental conditions. In our study, we examined the antiallergic activity of Brazilian green propolis (BGP) and isolated the active compound that can suppress an allergy-sensitive gene, IL-33, expression and eosinophilia. Ethanolic extract of BGP freeze-dried powder was fractionated with several solvent systems, and the active fractions were collected based on activity measurement. The single active compound was found by thin-layer chromatography. Using column chromatography and NMR, the active compound was isolated and identified as 3,5,7-trihydroxy-6,4'-dimethoxyflavone, also known as betuletol. Further, the antiallergic activity of that has been examined in PMA-induced up-regulation of IL-33 gene expression in Swiss 3T3 cells. Our data showed the IL-33 gene suppression both by BGP and the isolated active compound, betuletol. We also found that betuletol suppressed ERK phosphorylation, suggesting it could be effective in suppressing IL-33 mediated eosinophilic chronic inflammation and will provide new insights to develop potent therapeutics against allergic inflammations.","ja":"Propolis, a resinous substance produced by honeybees, has been used in folk medicine since ancient times due to its many biological benefits such as antitumor, antioxidant, antimicrobial, anti-inflammatory, and immunomodulatory effects. Propolis contains flavonoids, terpenoids, aromatic aldehydes, and alcohols, which vary with different climate and environmental conditions. In our study, we examined the antiallergic activity of Brazilian green propolis (BGP) and isolated the active compound that can suppress an allergy-sensitive gene, IL-33, expression and eosinophilia. Ethanolic extract of BGP freeze-dried powder was fractionated with several solvent systems, and the active fractions were collected based on activity measurement. The single active compound was found by thin-layer chromatography. Using column chromatography and NMR, the active compound was isolated and identified as 3,5,7-trihydroxy-6,4'-dimethoxyflavone, also known as betuletol. Further, the antiallergic activity of that has been examined in PMA-induced up-regulation of IL-33 gene expression in Swiss 3T3 cells. Our data showed the IL-33 gene suppression both by BGP and the isolated active compound, betuletol. We also found that betuletol suppressed ERK phosphorylation, suggesting it could be effective in suppressing IL-33 mediated eosinophilic chronic inflammation and will provide new insights to develop potent therapeutics against allergic inflammations."},"publication_date":"2022-08-25","publication_name":{"en":"Molecules","ja":"Molecules"},"volume":"Vol.27","number":"No.17","starting_page":"5459","ending_page":"5459","languages":["eng"],"referee":true,"identifiers":{"doi":["10.3390/molecules27175459"],"issn":["1420-3049"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"http://id.ndl.go.jp/bib/031985476","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1390855035370806400/","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85141839306&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=385521","label":"url"}],"paper_title":{"en":"Clinical Outcomes of Treatment for Tongue Cancer at Tokushima University Hospital","ja":"当科における舌癌の治療成績 (武田憲昭教授退任記念総説集)"},"authors":{"en":[{"name":"蔭山 麻美"},{"name":"Fukuda Junya"},{"name":"Azuma Takahiro"},{"name":"Kanamura Ryo"},{"name":"Kondou Eiji"},{"name":"Satou Gou"},{"name":"Abe Koji"},{"name":"Tamura Koichi"},{"name":"Kitamura Yoshiaki"},{"name":"Takeda Noriaki"}],"ja":[{"name":"蔭山 麻美"},{"name":"福田 潤弥"},{"name":"東 貴弘"},{"name":"金村 亮"},{"name":"近藤 英司"},{"name":"佐藤 豪"},{"name":"阿部 晃治"},{"name":"田村 公一"},{"name":"北村 嘉章"},{"name":"武田 憲昭"}]},"publication_date":"2022-02","publication_name":{"en":"Practica Oto-Rhino-Laryngologica. Suppl.","ja":"耳鼻咽喉科臨床 補冊"},"volume":"Vol.158","number":"No.0","starting_page":"157","ending_page":"162","languages":["jpn"],"referee":true,"identifiers":{"doi":["10.5631/jibirinsuppl.158.157"],"issn":["0912-1870"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"http://id.ndl.go.jp/bib/031985490","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1390573560406757888/","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85141849480&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=385509","label":"url"}],"paper_title":{"en":"Clinical Outcomes of Treatment for Hypopharyngeal Cancer at Tokushima University Hospital","ja":"当科における下咽頭癌の治療成績 (武田憲昭教授退任記念総説集)"},"authors":{"en":[{"name":"ISHITANI Keisuke"},{"name":"Katsuya Fujino"},{"name":"内藤 圭介"},{"name":"Kondou Eiji"},{"name":"Abe Koji"},{"name":"Tamura Koichi"},{"name":"Kitamura Yoshiaki"},{"name":"Takeda Noriaki"}],"ja":[{"name":"石谷 圭佑"},{"name":"藤野 勝也"},{"name":"内藤 圭介"},{"name":"近藤 英司"},{"name":"阿部 晃治"},{"name":"田村 公一"},{"name":"北村 嘉章"},{"name":"武田 憲昭"}]},"publication_date":"2022-02","publication_name":{"en":"Practica Oto-Rhino-Laryngologica. Suppl.","ja":"耳鼻咽喉科臨床 補冊"},"volume":"Vol.158","number":"No.0","starting_page":"163","ending_page":"170","languages":["jpn"],"referee":true,"identifiers":{"doi":["10.5631/jibirinsuppl.158.163"],"issn":["0912-1870"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"http://id.ndl.go.jp/bib/031985500","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1390292085423744640/","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85141835067&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=385500","label":"url"}],"paper_title":{"en":"Hearing Outcomes After Tympanoplasty for Cholesteatoma at Tokushima University Hospital","ja":"当科における真珠腫性中耳炎の手術成績 (武田憲昭教授退任記念総説集)"},"authors":{"en":[{"name":"山本 綾香"},{"name":"Endo Aki"},{"name":"Azuma Takahiro"},{"name":"Kondou Eiji"},{"name":"Satou Gou"},{"name":"Abe Koji"},{"name":"Kitamura Yoshiaki"},{"name":"Takeda Noriaki"}],"ja":[{"name":"山本 綾香"},{"name":"遠藤 亜紀"},{"name":"東 貴弘"},{"name":"近藤 英司"},{"name":"佐藤 豪"},{"name":"阿部 晃治"},{"name":"北村 嘉章"},{"name":"武田 憲昭"}]},"publication_date":"2022-02","publication_name":{"en":"Practica Oto-Rhino-Laryngologica. Suppl.","ja":"耳鼻咽喉科臨床 補冊"},"volume":"Vol.158","number":"No.0","starting_page":"171","ending_page":"174","languages":["jpn"],"referee":true,"identifiers":{"doi":["10.5631/jibirinsuppl.158.171"],"issn":["0912-1870"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"http://id.ndl.go.jp/bib/031985461","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1390855035377180032/","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85141839811&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=385497","label":"url"}],"paper_title":{"en":"Clinical Outcomes of Treatment for Laryngeal Cancer at Tokushima University Hospital","ja":"当科における喉頭癌の治療成績 (武田憲昭教授退任記念総説集)"},"authors":{"en":[{"name":"Kanamura Ryo"},{"name":"Satou Gou"},{"name":"Yamashita Takao"},{"name":"Abe Koji"},{"name":"Tamura Koichi"},{"name":"Kitamura Yoshiaki"},{"name":"Takeda Noriaki"}],"ja":[{"name":"金村 亮"},{"name":"佐藤 豪"},{"name":"山下 貴央"},{"name":"阿部 晃治"},{"name":"田村 公一"},{"name":"北村 嘉章"},{"name":"武田 憲昭"}]},"publication_date":"2022-02","publication_name":{"en":"Practica Oto-Rhino-Laryngologica. Suppl.","ja":"耳鼻咽喉科臨床 補冊"},"volume":"Vol.158","number":"No.0","starting_page":"151","ending_page":"156","languages":["jpn"],"referee":true,"identifiers":{"doi":["10.5631/jibirinsuppl.158.151"],"issn":["0912-1870"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116993","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/35105501","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=385671","label":"url"}],"paper_title":{"en":"New method to evaluate sequelae of static facial asymmetry in patients with facial palsy using three-dimensional scanning analysis.","ja":"New method to evaluate sequelae of static facial asymmetry in patients with facial palsy using three-dimensional scanning analysis."},"authors":{"en":[{"name":"Azuma Takahiro"},{"name":"Fuchigami Teruhiko"},{"name":"Nakamura Katsuhiko"},{"name":"Kondou Eiji"},{"name":"Satou Gou"},{"name":"Kitamura Yoshiaki"},{"name":"Takeda Noriaki"}],"ja":[{"name":"東 貴弘"},{"name":"渕上 輝彦"},{"name":"中村 克彦"},{"name":"近藤 英司"},{"name":"佐藤 豪"},{"name":"北村 嘉章"},{"name":"武田 憲昭"}]},"description":{"en":"The present findings suggest that affected-unaffected side differences in the depth of the nasolabial fold of the measured using three-dimensional scanning analysis can be used as an index of sequelae of static facial asymmetry. It is also suggested that the index can evaluate whether interventions are effective for the treatment of sequelae.","ja":"The present findings suggest that affected-unaffected side differences in the depth of the nasolabial fold of the measured using three-dimensional scanning analysis can be used as an index of sequelae of static facial asymmetry. It is also suggested that the index can evaluate whether interventions are effective for the treatment of sequelae."},"publication_date":"2022-01-29","publication_name":{"en":"Auris, Nasus, Larynx","ja":"Auris, Nasus, Larynx"},"volume":"Vol.49","number":"No.5","starting_page":"755","ending_page":"761","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.anl.2022.01.007"],"issn":["1879-1476"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/118083","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/35155781","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=394666","label":"url"}],"paper_title":{"en":"Efficacy of dual sublingual immunotherapy with Japanese cedar pollen and house dust mite allergens in patients with allergic rhinitis sensitized to multiple allergens.","ja":"Efficacy of dual sublingual immunotherapy with Japanese cedar pollen and house dust mite allergens in patients with allergic rhinitis sensitized to multiple allergens."},"authors":{"en":[{"name":"Fujii Tatsuya"},{"name":"Kitamura Yoshiaki"},{"name":"Kamimura Seiichiro"},{"name":"Ishitani Keisuke"},{"name":"Takeda Noriaki"}],"ja":[{"name":"藤井 達也"},{"name":"北村 嘉章"},{"name":"神村 盛一郎"},{"name":"Ishitani Keisuke"},{"name":"武田 憲昭"}]},"description":{"en":"3b, a case-controlled study.","ja":"3b, a case-controlled study."},"publication_date":"2022-01-21","publication_name":{"en":"Laryngoscope Investigative Otolaryngology","ja":"Laryngoscope Investigative Otolaryngology"},"volume":"Vol.7","number":"No.1","starting_page":"36","ending_page":"42","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1002/lio2.740"],"issn":["2378-8038"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/34996617","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=397205","label":"url"}],"paper_title":{"en":"Long-term changes in serum squamous cell carcinoma antigen levels after surgery in patients with sinonasal inverted papilloma.","ja":"Long-term changes in serum squamous cell carcinoma antigen levels after surgery in patients with sinonasal inverted papilloma."},"authors":{"en":[{"name":"Kitamura Yoshiaki"},{"name":"Kamimura Seiichiro"},{"name":"Fujii Tatsuya"},{"name":"Kanamura Ryo"},{"name":"Fukuda Junya"},{"name":"Kondou Eiji"},{"name":"Azuma Takahiro"},{"name":"Satou Gou"},{"name":"Takeda Noriaki"}],"ja":[{"name":"北村 嘉章"},{"name":"神村 盛一郎"},{"name":"藤井 達也"},{"name":"金村 亮"},{"name":"福田 潤弥"},{"name":"近藤 英司"},{"name":"東 貴弘"},{"name":"佐藤 豪"},{"name":"武田 憲昭"}]},"description":{"en":"These findings suggest that SCCA can be a tumor marker of IP. It is also suggested that postoperative elevation of SCCA levels is a clinical marker for monitoring the recurrence of IP during the follow-up period. A SCCA cut-off value of 1.85 ng/ml postoperatively may predict the subsequent recurrence of IP with high sensitivity and specificity.","ja":"These findings suggest that SCCA can be a tumor marker of IP. It is also suggested that postoperative elevation of SCCA levels is a clinical marker for monitoring the recurrence of IP during the follow-up period. A SCCA cut-off value of 1.85 ng/ml postoperatively may predict the subsequent recurrence of IP with high sensitivity and specificity."},"publication_date":"2022-01-04","publication_name":{"en":"Auris, Nasus, Larynx","ja":"Auris, Nasus, Larynx"},"volume":"Vol.49","number":"No.4","starting_page":"697","ending_page":"702","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.anl.2021.12.004"],"issn":["1879-1476"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116891","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/34511300","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=394667","label":"url"}],"paper_title":{"en":"Development of receptive vocabulary and verbal intelligence in Japanese children with unilateral hearing loss.","ja":"Development of receptive vocabulary and verbal intelligence in Japanese children with unilateral hearing loss."},"authors":{"en":[{"name":"Takeyama Takaaki"},{"name":"Shimada Aki"},{"name":"Sakamoto Yuki"},{"name":"Aoki Toshihito"},{"name":"Kondou Eiji"},{"name":"Nakano Seiichi"},{"name":"Fukuda Junya"},{"name":"Azuma Takahiro"},{"name":"Satou Gou"},{"name":"Okamoto Hidehiko"},{"name":"Kitamura Yoshiaki"},{"name":"Udaka Jiro"},{"name":"Takeda Noriaki"}],"ja":[{"name":"竹山 孝明"},{"name":"島田 亜紀"},{"name":"坂本 幸"},{"name":"青木 俊仁"},{"name":"近藤 英司"},{"name":"中野 誠一"},{"name":"福田 潤弥"},{"name":"東 貴弘"},{"name":"佐藤 豪"},{"name":"Okamoto Hidehiko"},{"name":"北村 嘉章"},{"name":"宇高 二良"},{"name":"武田 憲昭"}]},"description":{"en":"These findings suggest that the development of receptive vocabulary and verbal intelligence was delayed in preschool-age children with UHL and that most of them caught up to exhibit normal language ability after school admission.","ja":"These findings suggest that the development of receptive vocabulary and verbal intelligence was delayed in preschool-age children with UHL and that most of them caught up to exhibit normal language ability after school admission."},"publication_date":"2022-01","publication_name":{"en":"Auris, Nasus, Larynx","ja":"Auris, Nasus, Larynx"},"volume":"Vol.49","number":"No.3","starting_page":"335","ending_page":"341","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.anl.2021.08.002"],"issn":["1879-1476"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/117018","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/35466153","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=395904","label":"url"}],"paper_title":{"en":"Effects of sublingual immunotherapy with tablets or drops containing Japanese cedar pollen antigens on nasal symptoms and sleep disturbance in patients with Japanese cedar pollinosis.","ja":"Effects of sublingual immunotherapy with tablets or drops containing Japanese cedar pollen antigens on nasal symptoms and sleep disturbance in patients with Japanese cedar pollinosis."},"authors":{"en":[{"name":"Fujii Tatsuya"},{"name":"Kitamura Yoshiaki"},{"name":"Kamimura Seiichiro"},{"name":"Takeda Noriaki"}],"ja":[{"name":"藤井 達也"},{"name":"北村 嘉章"},{"name":"神村 盛一郎"},{"name":"武田 憲昭"}]},"description":{"en":"It is suggested that SLIT with JCP tablets improved both nasal symptoms and sleep disturbances at peak pollen period in patients with Japanese cedar pollinosis. SLIT with JCP tablets for one year was more effective than SLIT with JCP drops for two years and prophylactic treatment with antihistamines. J. Med. Invest. 69 : 97-100, February, 2022.","ja":"It is suggested that SLIT with JCP tablets improved both nasal symptoms and sleep disturbances at peak pollen period in patients with Japanese cedar pollinosis. SLIT with JCP tablets for one year was more effective than SLIT with JCP drops for two years and prophylactic treatment with antihistamines. J. Med. Invest. 69 : 97-100, February, 2022."},"publication_date":"2022","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.69","number":"No.1.2","starting_page":"97","ending_page":"100","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.69.97"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"http://repo.lib.tokushima-u.ac.jp/117076","label":"url"},{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/117076","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1390008089768552192/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=385528","label":"url"}],"paper_title":{"en":"Aural stimulation with capsaicin prevented pneumonia in dementia patients","ja":"カプサイシン軟膏による外耳道刺激は高齢認知症患者の肺炎を予防する"},"authors":{"en":[{"name":"Jinnouchi Osamu"},{"name":"Ohnishi Hiroki"},{"name":"Kondou Eiji"},{"name":"Kawata Ikuji"},{"name":"Bando Hiroyasu"},{"name":"Okamoto Hidehiko"},{"name":"Azuma Takahiro"},{"name":"Satou Gou"},{"name":"Kitamura Yoshiaki"},{"name":"Abe Koji"},{"name":"Takeda Noriaki"}],"ja":[{"name":"陣内 自治"},{"name":"大西 皓貴"},{"name":"近藤 英司"},{"name":"川田 育二"},{"name":"坂東 弘康"},{"name":"岡本 秀彦"},{"name":"東 貴弘"},{"name":"佐藤 豪"},{"name":"北村 嘉章"},{"name":"阿部 晃治"},{"name":"武田 憲昭"}]},"publication_date":"2021-09-20","publication_name":{"en":"Nippon Jibiinkoka Tokeibugeka Gakkai Kaiho","ja":"日本耳鼻咽喉科頭頸部外科学会会報"},"volume":"Vol.124","number":"No.9","starting_page":"1317","ending_page":"1318","languages":["jpn"],"referee":true,"identifiers":{"doi":["10.3950/jibiinkotokeibu.124.9_1317"],"issn":["2436-5793"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/117248","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/34578798","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=385407","label":"url"}],"paper_title":{"en":"Dietary Supplementation with Monosodium Glutamate Suppresses Chemotherapy-Induced Downregulation of the T1R3 Taste Receptor Subunit in Head and Neck Cancer Patients.","ja":"Dietary Supplementation with Monosodium Glutamate Suppresses Chemotherapy-Induced Downregulation of the T1R3 Taste Receptor Subunit in Head and Neck Cancer Patients."},"authors":{"en":[{"name":"Shono Hitoshi"},{"name":"Tsutsumi Rie"},{"name":"Beppu Kana"},{"name":"Matsushima Rina"},{"name":"Watanabe Suzuno"},{"name":"Fujimoto Chisa"},{"name":"Kanamura Ryo"},{"name":"Ohnishi Hiroki"},{"name":"Kondou Eiji"},{"name":"Azuma Takahiro"},{"name":"Satou Gou"},{"name":"Kawai Misako"},{"name":"Matsumoto Hideki"},{"name":"Kitamura Yoshiaki"},{"name":"Sakaue Hiroshi"},{"name":"Takeda Noriaki"}],"ja":[{"name":"庄野 仁志"},{"name":"堤 理恵"},{"name":"Beppu Kana"},{"name":"Matsushima Rina"},{"name":"Watanabe Suzuno"},{"name":"藤本 知佐"},{"name":"金村 亮"},{"name":"大西 皓貴"},{"name":"近藤 英司"},{"name":"東 貴弘"},{"name":"佐藤 豪"},{"name":"Kawai Misako"},{"name":"Matsumoto Hideki"},{"name":"北村 嘉章"},{"name":"阪上 浩"},{"name":"武田 憲昭"}]},"description":{"en":"(Background) We investigated the effect of dietary supplementation with monosodium glutamate (MSG) on chemotherapy-induced downregulation of the T1R3 taste receptor subunit expression in the tongue of patients with advanced head and neck cancer. (Methods) Patients undergoing two rounds of chemoradiotherapy were randomly allocated to a control or intervention group (dietary supplementation with MSG at 2.7 g/day during the second round of chemotherapy). The relative expression of T1R3, a subunit of both umami and sweet taste receptors, in the tongue was assessed by quantitative polymerase chain reaction analysis. Dysgeusia was assessed with a visual analog scale and daily energy intake was evaluated. (Results) T1R3 expression levels in the tongue, taste sensitivity, and daily energy intake were significantly reduced after the first round of chemotherapy compared with before treatment. Furthermore, these parameters significantly decreased after the second round of chemotherapy, but the extent of decrease was significantly attenuated in the MSG group compared with the control group. (Conclusions) MSG supplementation suppresses chemotherapy-induced dysgeusia, possibly due to the inhibition of the T1R3-containing taste receptor downregulation in the tongue, thereby increasing energy intake in patients with advanced head and neck cancer.","ja":"(Background) We investigated the effect of dietary supplementation with monosodium glutamate (MSG) on chemotherapy-induced downregulation of the T1R3 taste receptor subunit expression in the tongue of patients with advanced head and neck cancer. (Methods) Patients undergoing two rounds of chemoradiotherapy were randomly allocated to a control or intervention group (dietary supplementation with MSG at 2.7 g/day during the second round of chemotherapy). The relative expression of T1R3, a subunit of both umami and sweet taste receptors, in the tongue was assessed by quantitative polymerase chain reaction analysis. Dysgeusia was assessed with a visual analog scale and daily energy intake was evaluated. (Results) T1R3 expression levels in the tongue, taste sensitivity, and daily energy intake were significantly reduced after the first round of chemotherapy compared with before treatment. Furthermore, these parameters significantly decreased after the second round of chemotherapy, but the extent of decrease was significantly attenuated in the MSG group compared with the control group. (Conclusions) MSG supplementation suppresses chemotherapy-induced dysgeusia, possibly due to the inhibition of the T1R3-containing taste receptor downregulation in the tongue, thereby increasing energy intake in patients with advanced head and neck cancer."},"publication_date":"2021-08-24","publication_name":{"en":"Nutrients","ja":"Nutrients"},"volume":"Vol.13","number":"No.9","starting_page":"2921","ending_page":"2921","languages":["eng"],"referee":true,"identifiers":{"doi":["10.3390/nu13092921"],"issn":["2072-6643"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116494","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/34759144","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=385409","label":"url"}],"paper_title":{"en":"Effects of vocal nodules on acoustic characteristics of voice in children : an acoustic analysis of voice.","ja":"Effects of vocal nodules on acoustic characteristics of voice in children : an acoustic analysis of voice."},"authors":{"en":[{"name":"Aoki Toshihito"},{"name":"Takeyama Takaaki"},{"name":"Sakamoto Yuki"},{"name":"Shimada Aki"},{"name":"Kondou Eiji"},{"name":"Nakano Seiichi"},{"name":"Fukuda Junya"},{"name":"Azuma Takahiro"},{"name":"Satou Gou"},{"name":"Kitamura Yoshiaki"},{"name":"Hosokawa Kiyohito"},{"name":"Udaka Jiro"},{"name":"Takeda Noriaki"}],"ja":[{"name":"青木 俊仁"},{"name":"竹山 孝明"},{"name":"坂本 幸"},{"name":"島田 亜紀"},{"name":"近藤 英司"},{"name":"中野 誠一"},{"name":"福田 潤弥"},{"name":"東 貴弘"},{"name":"佐藤 豪"},{"name":"北村 嘉章"},{"name":"Hosokawa Kiyohito"},{"name":"宇高 二良"},{"name":"武田 憲昭"}]},"description":{"en":"Objective : In the present study, an attempt was made to evaluate the acoustic characteristics of voice in pediatric patients with vocal nodules using acoustic analysis of voice. Methods : Thirty-five pediatric patients with vocal nodules and 32 control children without dysphonia were enrolled in this study. Their voice samples were analyzed using the Multi-Dimensional Voice Program. Acoustic parameters of voice, such as pitch period perturbation quotient (PPQ), amplitude perturbation quotient (APQ), and noise-to-harmonic ratio (NHR), were measured. Results : In phonation at a loudness of over 80 dBA, the PPQ, APQ, and NHR values of the voice significantly increased in children with vocal nodules than in the control children without dysphonia. The sensitivities and specificities of PPQ, APQ, and NHR for prediction of vocal nodules in children were 62.86% and 84.38%, 74.29% and 75.00%, and 31.43% and 93.75%, respectively. Discussion : The present findings suggest that vocal nodules affect vocal fold vibration, resulting in impaired control of pitch and loudness leading to increased noise components. NHR could be used to evaluate the efficacy of treatment, such as voice rehabilitation, in pediatric patients with vocal nodules because of its high specificity for prediction of vocal nodules in children. J. Med. Invest. 68 : 276-279, August, 2021.","ja":"Objective : In the present study, an attempt was made to evaluate the acoustic characteristics of voice in pediatric patients with vocal nodules using acoustic analysis of voice. Methods : Thirty-five pediatric patients with vocal nodules and 32 control children without dysphonia were enrolled in this study. Their voice samples were analyzed using the Multi-Dimensional Voice Program. Acoustic parameters of voice, such as pitch period perturbation quotient (PPQ), amplitude perturbation quotient (APQ), and noise-to-harmonic ratio (NHR), were measured. Results : In phonation at a loudness of over 80 dBA, the PPQ, APQ, and NHR values of the voice significantly increased in children with vocal nodules than in the control children without dysphonia. The sensitivities and specificities of PPQ, APQ, and NHR for prediction of vocal nodules in children were 62.86% and 84.38%, 74.29% and 75.00%, and 31.43% and 93.75%, respectively. Discussion : The present findings suggest that vocal nodules affect vocal fold vibration, resulting in impaired control of pitch and loudness leading to increased noise components. NHR could be used to evaluate the efficacy of treatment, such as voice rehabilitation, in pediatric patients with vocal nodules because of its high specificity for prediction of vocal nodules in children. J. Med. Invest. 68 : 276-279, August, 2021."},"publication_date":"2021-08","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.68","number":"No.3.4","starting_page":"276","ending_page":"279","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.68.276"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/115938","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/32928603","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=385399","label":"url"}],"paper_title":{"en":"Vestibular and cochlear nerve enhancement on MRI and its correlation with vestibulocochlear functional deficits in patients with Ramsay Hunt syndrome.","ja":"Vestibular and cochlear nerve enhancement on MRI and its correlation with vestibulocochlear functional deficits in patients with Ramsay Hunt syndrome."},"authors":{"en":[{"name":"Takahashi Mika"},{"name":"Satou Gou"},{"name":"Toda Naoki"},{"name":"Azuma Takahiro"},{"name":"Nakamura Katsuhiko"},{"name":"Iwasaki Hidetaka"},{"name":"Miyoshi Hitomi"},{"name":"Matsuda Kazunori"},{"name":"Kitamura Yoshiaki"},{"name":"Abe Koji"},{"name":"Takao Shoichiro"},{"name":"Harada Masafumi"},{"name":"Takeda Noriaki"}],"ja":[{"name":"髙橋 美香"},{"name":"佐藤 豪"},{"name":"戸田 直紀"},{"name":"東 貴弘"},{"name":"中村 克彦"},{"name":"岩﨑 英隆"},{"name":"Miyoshi Hitomi"},{"name":"松田 和徳"},{"name":"北村 嘉章"},{"name":"阿部 晃治"},{"name":"髙尾 正一郎"},{"name":"原田 雅史"},{"name":"武田 憲昭"}]},"description":{"en":"In patients with RHS, the origin of vertigo may be superior vestibular neuritis, which is affected by reactive varicella-zoster virus from the geniculate ganglion of the facial nerve through the faciovestibular anastomosis. The results also suggested that in some RHS patients, inferior vestibular neuritis contributes to the development of vertigo and that the origin of refractory sensorineural hearing loss is cochlear neuritis.","ja":"Among RHS patients, 79%, 53%, 17% and 26% showed CP in the caloric test, abnormal responses to oVEMP and cVEMP, and refractory sensorineural hearing loss, respectively. SIinc rates of the SVN were significantly increased in RHS patients with CP in the caloric test, and with abnormal responses to oVEMP and cVEMP. SIinc rates of the SVN tended to increase in RHS patients with refractory sensorineural hearing loss (p = 0.052). SIinc rates of the IVN were significantly increased in RHS patients with abnormal responses to oVEMP and cVEMP, and refractory sensorineural hearing loss, but not in those with CP in the caloric test. SIinc rates of the CN were significantly increased in RHS patients with CP in the caloric test, abnormal response to oVEMP and refractory sensorineural hearing loss, but not in those with abnormal response to cVEMP."},"publication_date":"2021-06","publication_name":{"en":"Auris, Nasus, Larynx","ja":"Auris, Nasus, Larynx"},"volume":"Vol.48","number":"No.3","starting_page":"347","ending_page":"352","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.anl.2020.08.027"],"issn":["1879-1476"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://www.jstage.jst.go.jp/article/jibirin/114/5/114_391/_pdf","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1390569382247330944/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=385577","label":"url"}],"paper_title":{"en":"A Case of Hereditary Angioedema who Underwent Endoscopic Sinus Surgery Under General Anesthesia","ja":"全身麻酔下に内視鏡下鼻内副鼻腔手術を行った遺伝性血管性浮腫例"},"authors":{"en":[{"name":"Kamimura Seiichiro"},{"name":"Fujino Katsuya"},{"name":"Naito Keisuke"},{"name":"Kitamura Yoshiaki"},{"name":"Takeda Noriaki"}],"ja":[{"name":"神村 盛一郎"},{"name":"藤野 勝也"},{"name":"内藤 圭介"},{"name":"北村 嘉章"},{"name":"武田 憲昭"}]},"description":{"en":"
Hereditary angioedema (HAE) is an inherited disease characterized by angioedema, that is caused by a genetic abnormality of C1-inhibitor (C1-INH). Decrease or functional abnormality of the C1-INH protein leads to excessive production of bradykinin, which causes increased vascular permeability. Patients with HAE present with edema of the face, arms and legs, as also of the larynx and gastrointestinal tract. Notably, airway stenosis caused by laryngeal edema can be fatal. Upper airway surgery under general anesthesia in patients with HAE carries the risk of airway stenosis caused by surgical site edema and by laryngeal edema due to tracheal intubation. In one guideline for the management of HAE, administration of C1-INH (Berinert®P) prior to surgery is recommended as prophylaxis against the development of angioedema.
A 68-year-old female patient with HAE (type 1) was referred to our department with the chief complaint of pain in the right maxilla. She had undergone Caldwell-Luc surgery for sinusitis as a 13-year-old. CT showed two cysts in the right maxilla, and she was diagnosed as having maxillary cysts and scheduled for surgery. As she suffered from frequent attacks of HAE, we administered C1-INH to the patient prior to surgery, according to a guideline for the management of HAE, and the patient underwent endoscopic sinus surgery (ESS) under general anesthesia without HAE attacks during the perioperative period.
ESS under general anesthesia in a patient with HAE carries the risk of angioedema developing at the surgical site and laryngeal edema developing as a result of tracheal intubation. We could safely perform ESS without angioedema developing in the perioperative period, by prophylactic administration of C1-INH according to a guideline for the management of HAE.
","ja":"Hereditary angioedema (HAE) is an inherited disease characterized by angioedema, that is caused by a genetic abnormality of C1-inhibitor (C1-INH). Decrease or functional abnormality of the C1-INH protein leads to excessive production of bradykinin, which causes increased vascular permeability. Patients with HAE present with edema of the face, arms and legs, as also of the larynx and gastrointestinal tract. Notably, airway stenosis caused by laryngeal edema can be fatal. Upper airway surgery under general anesthesia in patients with HAE carries the risk of airway stenosis caused by surgical site edema and by laryngeal edema due to tracheal intubation. In one guideline for the management of HAE, administration of C1-INH (Berinert®P) prior to surgery is recommended as prophylaxis against the development of angioedema.
A 68-year-old female patient with HAE (type 1) was referred to our department with the chief complaint of pain in the right maxilla. She had undergone Caldwell-Luc surgery for sinusitis as a 13-year-old. CT showed two cysts in the right maxilla, and she was diagnosed as having maxillary cysts and scheduled for surgery. As she suffered from frequent attacks of HAE, we administered C1-INH to the patient prior to surgery, according to a guideline for the management of HAE, and the patient underwent endoscopic sinus surgery (ESS) under general anesthesia without HAE attacks during the perioperative period.
ESS under general anesthesia in a patient with HAE carries the risk of angioedema developing at the surgical site and laryngeal edema developing as a result of tracheal intubation. We could safely perform ESS without angioedema developing in the perioperative period, by prophylactic administration of C1-INH according to a guideline for the management of HAE.
"},"publication_date":"2021-05","publication_name":{"en":"Practica Oto-Rhino-Laryngologica","ja":"耳鼻咽喉科臨床"},"volume":"Vol.114","number":"No.5","starting_page":"391","ending_page":"396","languages":["jpn"],"referee":true,"identifiers":{"doi":["10.5631/jibirin.114.391"],"issn":["0032-6313"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116888","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/33799856","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=385405","label":"url"}],"paper_title":{"en":"Effects of Betahistine on the Development of Vestibular Compensation after Unilateral Labyrinthectomy in Rats.","ja":"Effects of Betahistine on the Development of Vestibular Compensation after Unilateral Labyrinthectomy in Rats."},"authors":{"en":[{"name":"Fukuda Junya"},{"name":"Matsuda Kazunori"},{"name":"Satou Gou"},{"name":"Kitahara Tadashi"},{"name":"Matsuoka Momoyo"},{"name":"Azuma Takahiro"},{"name":"Kitamura Yoshiaki"},{"name":"Tomita Koichi"},{"name":"Takeda Noriaki"}],"ja":[{"name":"福田 潤弥"},{"name":"松田 和徳"},{"name":"佐藤 豪"},{"name":"Kitahara Tadashi"},{"name":"Matsuoka Momoyo"},{"name":"東 貴弘"},{"name":"北村 嘉章"},{"name":"冨田 江一"},{"name":"武田 憲昭"}]},"description":{"en":"These findings suggest that betahistine facilitated the late, but not the initial, process of VC in UL rats.","ja":"These findings suggest that betahistine facilitated the late, but not the initial, process of VC in UL rats."},"publication_date":"2021-03-11","publication_name":{"en":"Brain Sciences","ja":"Brain Sciences"},"volume":"Vol.11","number":"No.3","starting_page":"360","ending_page":"360","languages":["eng"],"referee":true,"identifiers":{"doi":["10.3390/brainsci11030360"],"issn":["2076-3425"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/115970","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/33994462","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=385398","label":"url"}],"paper_title":{"en":"A new combined index of SUVmax of lymph node in PET / CT by a weighting coefficient plus its maximum minor axis in CECT to evaluate occult lymph node metastasis in clinical N0 patients with tongue cancer.","ja":"A new combined index of SUVmax of lymph node in PET / CT by a weighting coefficient plus its maximum minor axis in CECT to evaluate occult lymph node metastasis in clinical N0 patients with tongue cancer."},"authors":{"en":[{"name":"Kanamura Ryo"},{"name":"Suzuki Motoyuki"},{"name":"Otozai Shinji"},{"name":"Yoshii Tadashi"},{"name":"Okamoto Hidehiko"},{"name":"Kitamura Yoshiaki"},{"name":"Abe Koji"},{"name":"Fujii Takashi"},{"name":"Takeda Noriaki"}],"ja":[{"name":"金村 亮"},{"name":"Suzuki Motoyuki"},{"name":"Otozai Shinji"},{"name":"Yoshii Tadashi"},{"name":"Okamoto Hidehiko"},{"name":"北村 嘉章"},{"name":"阿部 晃治"},{"name":"Fujii Takashi"},{"name":"武田 憲昭"}]},"description":{"en":"To predict occult nodal metastasis in clinical N0 patients with tongue cancer, we developed combined index (CI) : SUVmax of the largest lymph node in PET / CT by weighting coefficient plus its maximum minor axis (< 10 mm) in contrast-enhanced CT (CECT). In this retrospective study, 57 clinical N0 patients with tongue cancer, who underwent elective supraomohyoid neck dissection at cervical levels of I-III were enrolled. The cutoff value of SUVmax of 2.0 obtained using receiver operating characteristic (ROC) analysis predicted the postoperative positive cervical levels containing metastatic lymph nodes from clinical N0 cervical levels in tongue cancer patients with a sensitivity of 54.5% and a specificity of 78.2%. The cutoff value of CI with weighting coefficient of 1.5 obtained using ROC analysis was 9.8 at the maximum area under the curve of 0.750. The cutoff value of 9.8 predicted the postoperative positive cervical levels containing metastatic lymph nodes from clinical N0 cervical levels in tongue cancer patients with a sensitivity of 68.2% and a specificity of 81.5%. These findings suggest that CI of functional PET / CT and morphological CECT components might improve the diagnostic performance of occult nodal metastasis to select clinical N0 patients with tongue cancer preferable for elective neck dissection. J. Med. Invest. 68 : 154-158, February, 2021.","ja":"To predict occult nodal metastasis in clinical N0 patients with tongue cancer, we developed combined index (CI) : SUVmax of the largest lymph node in PET / CT by weighting coefficient plus its maximum minor axis (< 10 mm) in contrast-enhanced CT (CECT). In this retrospective study, 57 clinical N0 patients with tongue cancer, who underwent elective supraomohyoid neck dissection at cervical levels of I-III were enrolled. The cutoff value of SUVmax of 2.0 obtained using receiver operating characteristic (ROC) analysis predicted the postoperative positive cervical levels containing metastatic lymph nodes from clinical N0 cervical levels in tongue cancer patients with a sensitivity of 54.5% and a specificity of 78.2%. The cutoff value of CI with weighting coefficient of 1.5 obtained using ROC analysis was 9.8 at the maximum area under the curve of 0.750. The cutoff value of 9.8 predicted the postoperative positive cervical levels containing metastatic lymph nodes from clinical N0 cervical levels in tongue cancer patients with a sensitivity of 68.2% and a specificity of 81.5%. These findings suggest that CI of functional PET / CT and morphological CECT components might improve the diagnostic performance of occult nodal metastasis to select clinical N0 patients with tongue cancer preferable for elective neck dissection. J. Med. Invest. 68 : 154-158, February, 2021."},"publication_date":"2021-02","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.68","number":"No.1.2","starting_page":"154","ending_page":"158","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.68.154"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/33461852","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=385401","label":"url"}],"paper_title":{"en":"Effects of sublingual immunotherapy on nasal symptoms and sleep disturbance in patients with Japanese cedar pollinosis.","ja":"Effects of sublingual immunotherapy on nasal symptoms and sleep disturbance in patients with Japanese cedar pollinosis."},"authors":{"en":[{"name":"Fujii Tatsuya"},{"name":"Kitamura Yoshiaki"},{"name":"Kamimura Seiichiro"},{"name":"Naito Keisuke"},{"name":"Takeda Noriaki"}],"ja":[{"name":"藤井 達也"},{"name":"北村 嘉章"},{"name":"神村 盛一郎"},{"name":"Naito Keisuke"},{"name":"武田 憲昭"}]},"description":{"en":"These findings suggested that SLIT with JC pollen extract suppressed nasal symptoms in patients with JC pollinosis, leading to improvements in AR-related sleep disturbance and daytime troubles with daily life.","ja":"These findings suggested that SLIT with JC pollen extract suppressed nasal symptoms in patients with JC pollinosis, leading to improvements in AR-related sleep disturbance and daytime troubles with daily life."},"publication_date":"2021-01-15","publication_name":{"en":"Auris, Nasus, Larynx","ja":"Auris, Nasus, Larynx"},"volume":"Vol.48","number":"No.4","starting_page":"653","ending_page":"658","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.anl.2021.01.004"],"issn":["1879-1476"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/116050","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/33614927","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=385391","label":"url"}],"paper_title":{"en":"Effects of narrow-band UVB on nasal symptom and upregulation of histamine H1 receptor mRNA in allergic rhinitis model rats","ja":"Effects of narrow-band UVB on nasal symptom and upregulation of histamine H1 receptor mRNA in allergic rhinitis model rats"},"authors":{"en":[{"name":"Kamimura Seiichiro"},{"name":"Kitamura Yoshiaki"},{"name":"Fujii Tatsuya"},{"name":"Okamoto Kentaro"},{"name":"Sanada Nanae"},{"name":"Okajima Natsuki"},{"name":"Wakugawa Tomoharu"},{"name":"Fukui Hiroyuki"},{"name":"Mizuguchi Hiroyuki"},{"name":"Takeda Noriaki"}],"ja":[{"name":"神村 盛一郎"},{"name":"北村 嘉章"},{"name":"藤井 達也"},{"name":"Okamoto Kentaro"},{"name":"Sanada Nanae"},{"name":"Okajima Natsuki"},{"name":"Wakugawa Tomoharu"},{"name":"福井 裕行"},{"name":"水口 博之"},{"name":"武田 憲昭"}]},"description":{"en":"NA.","ja":"Intranasal pre-irradiation with narrow-band UVB dose-dependently inhibited sneezes and upregulation of H1R gene expression of the nasal mucosa in AR model rats, suggesting that the inhibition of nasal upregulation of H1R gene expression suppressed nasal symptom. The suppression after narrow-band UVB irradiation at a dose of 600 mJ/cm"},"publication_date":"2021-01-08","publication_name":{"en":"Laryngoscope Investigative Otolaryngology","ja":"Laryngoscope Investigative Otolaryngology"},"volume":"Vol.6","number":"No.1","starting_page":"34","ending_page":"41","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1002/lio2.518"],"issn":["2378-8038"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/115983","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/33994477","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=385392","label":"url"}],"paper_title":{"en":"Differential cytokine profiles in pediatric patients with PFAPA syndrome and recurrent tonsillitis.","ja":"Differential cytokine profiles in pediatric patients with PFAPA syndrome and recurrent tonsillitis."},"authors":{"en":[{"name":"Nakano Seiichi"},{"name":"Kondou Eiji"},{"name":"Iwasaki Hidetaka"},{"name":"Akizuki Hironori"},{"name":"Matsuda Kazunori"},{"name":"Azuma Takahiro"},{"name":"Satou Gou"},{"name":"Kitamura Yoshiaki"},{"name":"Abe Koji"},{"name":"Takeda Noriaki"}],"ja":[{"name":"中野 誠一"},{"name":"近藤 英司"},{"name":"岩﨑 英隆"},{"name":"秋月 裕則"},{"name":"松田 和徳"},{"name":"東 貴弘"},{"name":"佐藤 豪"},{"name":"北村 嘉章"},{"name":"阿部 晃治"},{"name":"武田 憲昭"}]},"description":{"en":"Objective : An attempt was made to identify characteristic cytokine profiles to distinguish periodic fever with aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPAS) from recurrent tonsillitis, of which clinical manifestations are similar to those of PFAPAS in children. Methods : Serum concentrations of IL-6, IL-4 and IFN-γ were measured during febrile episodes in pediatric patients. Results : The levels of IL-6 during febrile episodes were markedly increased above the upper limit of normal ranges in patients with both PFAPAS and recurrent tonsillitis, but there were no significant differences between groups. The levels of IL-4 during febrile episodes in PFAPAS patients were significantly lower than those in recurrent tonsillitis patients. The levels of IFN-γ during febrile episodes in PFAPAS patients were significantly higher than those in recurrent tonsillitis patients. Conclusion : In pediatric patients with PFAPAS, despite an increase of IL-6, IL-4 was suppressed with a marked increase of IFN-γ during febrile episodes. On the contrary, in febrile pediatric patients with recurrent tonsillitis, both IL-6 and IL-4, but not IFN-γ were increased. The characteristic cytokine profiles of IL-6, IL-4 and IFN-γ can be used for differential diagnosis of PFAPAS from recurrent tonsillitis in children in clinical ear, nose and throat (ENT) settings. J. Med. Invest. 68 : 38-41, February, 2021.","ja":"Objective : An attempt was made to identify characteristic cytokine profiles to distinguish periodic fever with aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPAS) from recurrent tonsillitis, of which clinical manifestations are similar to those of PFAPAS in children. Methods : Serum concentrations of IL-6, IL-4 and IFN-γ were measured during febrile episodes in pediatric patients. Results : The levels of IL-6 during febrile episodes were markedly increased above the upper limit of normal ranges in patients with both PFAPAS and recurrent tonsillitis, but there were no significant differences between groups. The levels of IL-4 during febrile episodes in PFAPAS patients were significantly lower than those in recurrent tonsillitis patients. The levels of IFN-γ during febrile episodes in PFAPAS patients were significantly higher than those in recurrent tonsillitis patients. Conclusion : In pediatric patients with PFAPAS, despite an increase of IL-6, IL-4 was suppressed with a marked increase of IFN-γ during febrile episodes. On the contrary, in febrile pediatric patients with recurrent tonsillitis, both IL-6 and IL-4, but not IFN-γ were increased. The characteristic cytokine profiles of IL-6, IL-4 and IFN-γ can be used for differential diagnosis of PFAPAS from recurrent tonsillitis in children in clinical ear, nose and throat (ENT) settings. J. Med. Invest. 68 : 38-41, February, 2021."},"publication_date":"2021","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.68","number":"No.1.2","starting_page":"38","ending_page":"41","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.68.38"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://cir.nii.ac.jp/crid/1391975831221875712/","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=373462","label":"url"}],"paper_title":{"en":"Transnasal Endoscopic Surgery for Juvenile Angiofibroma Involving the Pterygopalatine Fossa","ja":"経鼻内視鏡手術にて摘出した翼口蓋窩に進展した若年性血管線維腫例"},"authors":{"en":[{"name":"Kageyama Asami"},{"name":"Kitamura Yoshiaki"},{"name":"Koda Hirokazu"},{"name":"Nakano Seiichi"},{"name":"Kamimura Seiichiro"},{"name":"Matsuda Kazunori"},{"name":"Abe Koji"},{"name":"Takeda Noriaki"}],"ja":[{"name":"蔭山 麻美"},{"name":"北村 嘉章"},{"name":"幸田 裕和"},{"name":"中野 誠一"},{"name":"神村 盛一郎"},{"name":"松田 和徳"},{"name":"阿部 晃治"},{"name":"武田 憲昭"}]},"description":{"en":"Juvenile angiofibroma (JA) is an uncommon, locally invasive, highly vascular and benign tumor that occurs in adolescent males. Established external surgical procedures for resection of JA include lateral rhinotomy, midfacial degloving, and transpalatal or infratemporal approaches; however, transnasal endoscopic approaches are increasingly being used because of advances in surgical techniques and endoscopic instrumentation. We report the case of a 14-year-old male who presented with left nasal obstruction and repeated epistaxis. A smooth reddish and hemorrhagic tumor was found in the left posterior nasal cavity. Computed tomography and magnetic resonance imaging showed a markedly enhanced tumor of approximately 40 mm in diameter that had obstructed the left posterior nasal cavity and nasopharynx, with occupancy of the pterygopalatine fossa. The case was diagnosed as Radkowski stage IIB. Preoperative embolization was performed to reduce tumor vascularity and improve visualization for surgical removal. Transnasal endoscopic surgery was used to resect the tumor en bloc after clipping the left maxillary artery. Intraoperative bleeding was 80 mL. To prevent recurrence, careful attention must be paid to tumor invasion into the Vidian canal. The postoperative course of our patient was uneventful, and there has been no evidence of recurrence for over one and a half years since surgery.
","ja":"若年性血管線維腫は思春期男子に好発し,頻回の鼻出血や鼻閉をきたす比較的稀な良性腫瘍である.治療の第一選択は手術であるが,非常に血流に富む腫瘍のため,従来は経上顎洞法,外側鼻切開法,経口蓋法などが行われてきた.近年は手術手技や機器の発展に伴い内視鏡下摘出術の適応が広がってきている.今回,我々は経鼻内視鏡手術で摘出した翼口蓋窩に進展した若年性血管線維腫例を経験したので報告する.症例は14歳男性で左鼻閉と反復する鼻出血を主訴に近医耳鼻科を受診し,左鼻腔内に腫瘍性病変を指摘され,当科紹介となった.初診時の鼻内所見では左鼻腔後方に表面平滑な赤色腫瘤を認めた.画像所見にて左鼻腔後方から上咽頭,そして翼口蓋窩を占拠する著明な造影効果のある腫瘤を認め,血管造影で栄養血管を確認し若年性血管線維腫のRadkowskiの分類StageIIBと診断した.術中の出血を抑制するために,手術当日に選択的血管塞栓療法を施行した.経鼻内視鏡下に腫瘍を一塊に摘出し,術中の出血を80 mlに抑制できた.若年性血管線維腫の再発部位は翼突管が最多であると報告されており,摘出術では翼突管への腫瘍の残存に注意する必要があると考えられた.
"},"publication_date":"2020-12","publication_name":{"en":"Japanese Journal of Rhinology","ja":"日本鼻科学会会誌"},"volume":"Vol.59","number":"No.4","starting_page":"318","ending_page":"324","languages":["jpn"],"referee":true,"identifiers":{"doi":["10.7248/jjrhi.59.318"],"issn":["0910-9153"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=375741","label":"url"}],"paper_title":{"en":"レンコンエキスパウダー摂取による鼻と眼のアレルギー症状軽減効果の検証―プラセボ対照ランダム化二重盲検並行群間比較試験―","ja":"レンコンエキスパウダー摂取による鼻と眼のアレルギー症状軽減効果の検証―プラセボ対照ランダム化二重盲検並行群間比較試験―"},"authors":{"en":[{"name":"永峰 賢一"},{"name":"竹内 心"},{"name":"中川 秀紀"},{"name":"海老原 淑子"},{"name":"Wakugawa Tomoharu"},{"name":"Kitamura Yoshiaki"},{"name":"Fukui Hiroyuki"},{"name":"Mizuguchi Hiroyuki"},{"name":"Takeda Noriaki"}],"ja":[{"name":"永峰 賢一"},{"name":"竹内 心"},{"name":"中川 秀紀"},{"name":"海老原 淑子"},{"name":"湧川 朝治"},{"name":"北村 嘉章"},{"name":"福井 裕行"},{"name":"水口 博之"},{"name":"武田 憲昭"}]},"publication_date":"2020-09","publication_name":{"en":"Japanese Pharmacology & Therapeutics","ja":"薬理と治療"},"volume":"Vol.48","number":"No.9","starting_page":"1559","ending_page":"1569","languages":["jpn"],"referee":true,"identifiers":{"issn":["0386-3603"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=375636","label":"url"}],"paper_title":{"en":"Identification and characterization of the anti-allergic compound from lotus root.","ja":"Identification and characterization of the anti-allergic compound from lotus root."},"authors":{"en":[{"name":"Tomoharu Wakugawa"},{"name":"Kenichi Nagamine"},{"name":"Miharu Hiramatsu"},{"name":"Mayuko Takeda"},{"name":"Chika Kawata"},{"name":"Yoshiki Kashiwada"},{"name":"Keiko Shinohara"},{"name":"Eiji Sawada"},{"name":"Masami Yabumoto"},{"name":"Fujino Hiromichi"},{"name":"Kitamura Yoshiaki"},{"name":"Fukui Hiroyuki"},{"name":"Takeda Noriaki"},{"name":"Mizuguchi Hiroyuki"}],"ja":[{"name":"湧川 朝治"},{"name":"Kenichi Nagamine"},{"name":"Miharu Hiramatsu"},{"name":"Mayuko Takeda"},{"name":"Chika Kawata"},{"name":"Yoshiki Kashiwada"},{"name":"Keiko Shinohara"},{"name":"Eiji Sawada"},{"name":"Masami Yabumoto"},{"name":"藤野 裕道"},{"name":"北村 嘉章"},{"name":"福井 裕行"},{"name":"武田 憲昭"},{"name":"水口 博之"}]},"publication_date":"2020-08","publication_name":{"en":"Traditional & Kampo Medicine","ja":"Traditional & Kampo Medicine"},"volume":"Vol.7","number":"No.2","starting_page":"85","ending_page":"95","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1002/tkm2.1249"],"issn":["2053-4515"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/115430","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/33148907","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=373460","label":"url"}],"paper_title":{"en":"Effects of corticosteroid on mRNA levels of histamine H1 receptor in nasal mucosa of healthy participants and HeLa cells.","ja":"Effects of corticosteroid on mRNA levels of histamine H1 receptor in nasal mucosa of healthy participants and HeLa cells."},"authors":{"en":[{"name":"Kitamura Yoshiaki"},{"name":"Kamimura Seiichiro"},{"name":"Fujii Tatsuya"},{"name":"Mizuguchi Hiroyuki"},{"name":"Naito Keisuke"},{"name":"Kondou Eiji"},{"name":"Matsuda Kazunori"},{"name":"Azuma Takahiro"},{"name":"Satou Gou"},{"name":"Fukui Hiroyuki"},{"name":"Takeda Noriaki"}],"ja":[{"name":"北村 嘉章"},{"name":"神村 盛一郎"},{"name":"藤井 達也"},{"name":"水口 博之"},{"name":"Naito Keisuke"},{"name":"近藤 英司"},{"name":"松田 和徳"},{"name":"東 貴弘"},{"name":"佐藤 豪"},{"name":"福井 裕行"},{"name":"武田 憲昭"}]},"description":{"en":"The purpose of this study is to examine the effect of intranasal corticosteroid (INCS) administration on histamine H1 receptor (H1R) gene expression in the nasal mucosa of healthy participants and the effects of dexamethasone on basal and histamine-induced H1R mRNA expression, and histamine-induced phosphorylation of extracellular signal-regulated kinase (ERK) in HeLa cells. Sixteen healthy participants were given INCS once daily for a week. After pretreatment of dexamethasone, HeLa cells were treated with histamine. Levels of H1R mRNA and phosphorylation of ERK were measured using real time PCR and immunoblot analysis, respectively. Levels of H1R mRNA in the nasal mucosa of healthy participants receiving INCS was significantly decreased. Dexamethasone suppressed basal levels of H1R mRNA, and histamine-induced up-regulation of H1R mRNA and ERK phosphorylation in HeLa cells. These data suggested that corticosteroid inhibited both basal transcription and histamine-induced transcriptional activation of H1R through its suppression of ERK phosphorylation in the signaling pathway involved in H1R gene transcription. It is further suggested that pre-seasonal prophylactic administration of INCS suppresses both basal and pollen-induced upregulation of H1R gene expression in the nasal mucosa of patients with pollinosis, leading to prevention of the exacerbation of nasal symptoms during peak pollen season. J. Med. Invest. 67 : 311-314, August, 2020.","ja":"The purpose of this study is to examine the effect of intranasal corticosteroid (INCS) administration on histamine H1 receptor (H1R) gene expression in the nasal mucosa of healthy participants and the effects of dexamethasone on basal and histamine-induced H1R mRNA expression, and histamine-induced phosphorylation of extracellular signal-regulated kinase (ERK) in HeLa cells. Sixteen healthy participants were given INCS once daily for a week. After pretreatment of dexamethasone, HeLa cells were treated with histamine. Levels of H1R mRNA and phosphorylation of ERK were measured using real time PCR and immunoblot analysis, respectively. Levels of H1R mRNA in the nasal mucosa of healthy participants receiving INCS was significantly decreased. Dexamethasone suppressed basal levels of H1R mRNA, and histamine-induced up-regulation of H1R mRNA and ERK phosphorylation in HeLa cells. These data suggested that corticosteroid inhibited both basal transcription and histamine-induced transcriptional activation of H1R through its suppression of ERK phosphorylation in the signaling pathway involved in H1R gene transcription. It is further suggested that pre-seasonal prophylactic administration of INCS suppresses both basal and pollen-induced upregulation of H1R gene expression in the nasal mucosa of patients with pollinosis, leading to prevention of the exacerbation of nasal symptoms during peak pollen season. J. Med. Invest. 67 : 311-314, August, 2020."},"publication_date":"2020-08","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.67","number":"No.3.4","starting_page":"311","ending_page":"314","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.67.311"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/115427","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/33148904","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=373459","label":"url"}],"paper_title":{"en":"Identification of pyrogallol from Awa-tea as an anti-allergic compound that suppresses nasal symptoms and IL-9 gene expression.","ja":"Identification of pyrogallol from Awa-tea as an anti-allergic compound that suppresses nasal symptoms and IL-9 gene expression."},"authors":{"en":[{"name":"Nakano Tomohiro"},{"name":"Ikeda Mitsuhiro"},{"name":"Wakugawa Tomoharu"},{"name":"Kashiwada Yoshiki"},{"name":"Kaminuma Osamu"},{"name":"Kitamura Noriko"},{"name":"Yabumoto Masam"},{"name":"Fujino Hiromichi"},{"name":"Kitamura Yoshiaki"},{"name":"Fukui Hiroyuki"},{"name":"Takeda Noriaki"},{"name":"Mizuguchi Hiroyuki"}],"ja":[{"name":"Nakano Tomohiro"},{"name":"Ikeda Mitsuhiro"},{"name":"Wakugawa Tomoharu"},{"name":"Kashiwada Yoshiki"},{"name":"Kaminuma Osamu"},{"name":"Kitamura Noriko"},{"name":"Yabumoto Masam"},{"name":"Fujino Hiromichi"},{"name":"北村 嘉章"},{"name":"福井 裕行"},{"name":"武田 憲昭"},{"name":"水口 博之"}]},"description":{"en":"As the expression level of allergic disease sensitive genes are correlated with the severity of allergic symptoms, suppression of these gene expressions could be promising therapeutics. We demonstrated that protein kinase Cδ / heat shock protein 90-mediated H1R gene expression signaling and nuclear factor of activated T-cells (NFAT)-mediated IL-9 gene expression signaling are responsible for the pathogenesis of pollinosis. Treatment with Awa-tea combined with wild grape hot water extract suppressed these signaling and alleviated nasal symptoms in toluene-2,4-diisocyanate (TDI)-sensitized rats. However, the underlying mechanism of its anti-allergic activity is not elucidated yet. Here, we sought to identify an anti-allergic compound from Awa-tea and pyrogallol was identified as an active compound. Pyrogallol strongly suppressed ionomycin-induced up-regulation of IL-9 gene expression in RBL-2H3 cells. Treatment with pyrogallol in combination with epinastine alleviated nasal symptoms and suppressed up-regulation of IL-9 gene expression in TDI-sensitized rats. Pyrogallol itself did not inhibit calcineurin phosphatase activity. However, pyrogallol suppressed ionomycin-induced dephosphorylation and nuclear translocation of NFAT. These data suggest pyrogallol is an anti-allergic compound in Awa-tea and it suppressed NFAT-mediated IL-9 gene expression through the inhibition of dephosphorylation of NFAT. This might be the underlying mechanism of the therapeutic effects of combined therapy of pyrogallol with antihistamine. J. Med. Invest. 67 : 289-297, August, 2020.","ja":"As the expression level of allergic disease sensitive genes are correlated with the severity of allergic symptoms, suppression of these gene expressions could be promising therapeutics. We demonstrated that protein kinase Cδ / heat shock protein 90-mediated H1R gene expression signaling and nuclear factor of activated T-cells (NFAT)-mediated IL-9 gene expression signaling are responsible for the pathogenesis of pollinosis. Treatment with Awa-tea combined with wild grape hot water extract suppressed these signaling and alleviated nasal symptoms in toluene-2,4-diisocyanate (TDI)-sensitized rats. However, the underlying mechanism of its anti-allergic activity is not elucidated yet. Here, we sought to identify an anti-allergic compound from Awa-tea and pyrogallol was identified as an active compound. Pyrogallol strongly suppressed ionomycin-induced up-regulation of IL-9 gene expression in RBL-2H3 cells. Treatment with pyrogallol in combination with epinastine alleviated nasal symptoms and suppressed up-regulation of IL-9 gene expression in TDI-sensitized rats. Pyrogallol itself did not inhibit calcineurin phosphatase activity. However, pyrogallol suppressed ionomycin-induced dephosphorylation and nuclear translocation of NFAT. These data suggest pyrogallol is an anti-allergic compound in Awa-tea and it suppressed NFAT-mediated IL-9 gene expression through the inhibition of dephosphorylation of NFAT. This might be the underlying mechanism of the therapeutic effects of combined therapy of pyrogallol with antihistamine. J. Med. Invest. 67 : 289-297, August, 2020."},"publication_date":"2020-08","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.67","number":"No.3.4","starting_page":"289","ending_page":"297","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.67.289"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://cir.nii.ac.jp/crid/1390285300155408000/","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85087378859&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=373463","label":"url"}],"paper_title":{"en":"A Case of Rosai-Dorfman Disease with Multiple Extranodal Lesion","ja":"多発する節外病変を認めたRosai-Dorfman病例"},"authors":{"en":[{"name":"Yamamoto Ayaka"},{"name":"Azuma Takahiro"},{"name":"Kamimura Seiichiro"},{"name":"Kitamura Yoshiaki"},{"name":"Takeda Noriaki"}],"ja":[{"name":"山本 綾香"},{"name":"東 貴弘"},{"name":"神村 盛一郎"},{"name":"北村 嘉章"},{"name":"武田 憲昭"}]},"description":{"en":"Rosai-Dorfman disease is a rare histiocytic disorder characterized by accumulation of histiocytes in the affected tissue. Herein we report on a case of Rosai-Dorfman disease with multiple lymphadenopathy and multiple extranodal lesions. A 22-year-old woman was referred to our hospital with bilateral submandibular swelling and a localized swelling in the root of the nose. Endoscopic examination revealed mass lesions in both nasal cavities and the subglottic area. A full-body CT revealed multiple nasal masses, cervical lymphadenopathy, and an intrathymic mass. We diagnosed her as having Rosai-Dorfman disease based on the histopathological findings of accumulation of histiocytes and emperipolesis in the nasal lesion and cervical lymph node specimens. Histopathological examination is required for the diagnosis of Rosai-Dorfman disease. After steroid treatment for 3 months, reduction in the size of the lymph nodes in the neck, nasal cavity lesions, and intrathymic mass was noted. However, the size of the subglottic mass remained almost unchanged. In this case, steroid treatment was mostly effective on the lesions. In case of airway obstruction due to increase in the size of the subglottic mass, surgical resection should be indicated.
","ja":"Rosai-Dorfman disease is a rare histiocytic disorder characterized by accumulation of histiocytes in the affected tissue. Herein we report on a case of Rosai-Dorfman disease with multiple lymphadenopathy and multiple extranodal lesions. A 22-year-old woman was referred to our hospital with bilateral submandibular swelling and a localized swelling in the root of the nose. Endoscopic examination revealed mass lesions in both nasal cavities and the subglottic area. A full-body CT revealed multiple nasal masses, cervical lymphadenopathy, and an intrathymic mass. We diagnosed her as having Rosai-Dorfman disease based on the histopathological findings of accumulation of histiocytes and emperipolesis in the nasal lesion and cervical lymph node specimens. Histopathological examination is required for the diagnosis of Rosai-Dorfman disease. After steroid treatment for 3 months, reduction in the size of the lymph nodes in the neck, nasal cavity lesions, and intrathymic mass was noted. However, the size of the subglottic mass remained almost unchanged. In this case, steroid treatment was mostly effective on the lesions. In case of airway obstruction due to increase in the size of the subglottic mass, surgical resection should be indicated.
"},"publication_date":"2020-05","publication_name":{"en":"Practica Oto-Rhino-Laryngologica","ja":"耳鼻咽喉科臨床"},"volume":"Vol.113","number":"No.5","starting_page":"323","ending_page":"329","languages":["jpn"],"referee":true,"identifiers":{"doi":["10.5631/jibirin.113.323"],"issn":["0032-6313"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=375893","label":"url"}],"paper_title":{"en":"ヒスタミンH1受容体とIL-33遺伝子発現亢進に対する小青竜湯の抑制効果","ja":"ヒスタミンH1受容体とIL-33遺伝子発現亢進に対する小青竜湯の抑制効果"},"authors":{"en":[{"name":"Nakano Seiichi"},{"name":"Kitamura Yoshiaki"},{"name":"Kamimura Seiichiro"},{"name":"Mizuguchi Hiroyuki"},{"name":"Fukui Hiroyuki"},{"name":"Takeda Noriaki"}],"ja":[{"name":"中野 誠一"},{"name":"北村 嘉章"},{"name":"神村 盛一郎"},{"name":"水口 博之"},{"name":"福井 裕行"},{"name":"武田 憲昭"}]},"publication_date":"2020-04-09","publication_name":{"en":"Japanese Journal of Rhinology","ja":"日本鼻科学会会誌"},"volume":"Vol.59","number":"No.1","starting_page":"73","ending_page":"74","languages":["jpn"],"referee":true,"identifiers":{"doi":["10.7248/jjrhi.59.73"],"issn":["1883-7077"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/32022628","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=373394","label":"url"}],"paper_title":{"en":"Daily auricular stimulation with capsaicin ointment improved cough reflex sensitivity in elderly patients with dysphagia: a pilot study.","ja":"Daily auricular stimulation with capsaicin ointment improved cough reflex sensitivity in elderly patients with dysphagia: a pilot study."},"authors":{"en":[{"name":"Ohnishi Hiroki"},{"name":"Jinnouchi Osamu"},{"name":"Agawa Seiji"},{"name":"Kondou Eiji"},{"name":"Kawata Ikuji"},{"name":"Okamoto Hidehiko"},{"name":"Azuma Takahiro"},{"name":"Satou Gou"},{"name":"Kitamura Yoshiaki"},{"name":"Abe Koji"},{"name":"Takeda Noriaki"}],"ja":[{"name":"Ohnishi Hiroki"},{"name":"陣内 自治"},{"name":"Agawa Seiji"},{"name":"近藤 英司"},{"name":"Kawata Ikuji"},{"name":"Okamoto Hidehiko"},{"name":"東 貴弘"},{"name":"佐藤 豪"},{"name":"北村 嘉章"},{"name":"阿部 晃治"},{"name":"武田 憲昭"}]},"description":{"en":"Daily auricular stimulation with capsaicin ointment would be a safe and effective intervention to prevent pneumonia in elderly with a risk of aspiration.","ja":"Daily auricular stimulation with capsaicin ointment would be a safe and effective intervention to prevent pneumonia in elderly with a risk of aspiration."},"publication_date":"2020-02-05","publication_name":{"en":"Acta Oto-Laryngologica","ja":"Acta Oto-Laryngologica"},"volume":"Vol.140","number":"No.3","starting_page":"249","ending_page":"253","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1080/00016489.2020.1716993"],"issn":["1651-2251"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/114758","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/32378624","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=373392","label":"url"}],"paper_title":{"en":"Electroneurography cannot predict when facial synkinesis develops in patients with facial palsy.","ja":"Electroneurography cannot predict when facial synkinesis develops in patients with facial palsy."},"authors":{"en":[{"name":"Azuma Takahiro"},{"name":"Nakamura Katsuhiko"},{"name":"Takahashi Mika"},{"name":"Miyoshi Hitomi"},{"name":"Toda Naoki"},{"name":"Iwasaki Hidetaka"},{"name":"Fuchigami Teruhiko"},{"name":"Satou Gou"},{"name":"Kitamura Yoshiaki"},{"name":"Abe Koji"},{"name":"Takeda Noriaki"}],"ja":[{"name":"東 貴弘"},{"name":"中村 克彦"},{"name":"髙橋 美香"},{"name":"Miyoshi Hitomi"},{"name":"戸田 直紀"},{"name":"岩﨑 英隆"},{"name":"Fuchigami Teruhiko"},{"name":"佐藤 豪"},{"name":"北村 嘉章"},{"name":"阿部 晃治"},{"name":"武田 憲昭"}]},"description":{"en":"The objective of this study is to clarify when facial palsy patients with lower value of Electroneurography (ENoG) should begin the rehabilitation to prevent the development of facial synkinesis. For this purpose, we examined the relationship between the value of ENoG measured 10-14 days after facial palsy onset and the onset day of the development of oral-ocular synkinesis. Sixteen patients with facial palsy including 11 with Bell's palsy and 5 with Ramsay Hunt syndrome (7 men and 9 women ; 15-73 years old ; mean age, 41.6 years) were enrolled in this study. There was no correlation between ENoG value and the onset day of the development of oral-ocular synkinesis (ρ = .09, p = .73). Oral-ocular synkinesis began to develop in 4.0 ± 0.7 months (mean ± SD ; range : 3.1-5.0 months) after facial palsy onset regardless of ENoG value. In conclusion, ENoG value cannot predict when facial synkinesis develops in patients with facial palsy. We recommend that facial palsy patients with a high risk for the development of synkinesis begin the biofeedback rehabilitation with mirror to prevent the development of facial synkinesis 3 months after facial palsy onset. J. Med. Invest. 67 : 87-89, February, 2020.","ja":"The objective of this study is to clarify when facial palsy patients with lower value of Electroneurography (ENoG) should begin the rehabilitation to prevent the development of facial synkinesis. For this purpose, we examined the relationship between the value of ENoG measured 10-14 days after facial palsy onset and the onset day of the development of oral-ocular synkinesis. Sixteen patients with facial palsy including 11 with Bell's palsy and 5 with Ramsay Hunt syndrome (7 men and 9 women ; 15-73 years old ; mean age, 41.6 years) were enrolled in this study. There was no correlation between ENoG value and the onset day of the development of oral-ocular synkinesis (ρ = .09, p = .73). Oral-ocular synkinesis began to develop in 4.0 ± 0.7 months (mean ± SD ; range : 3.1-5.0 months) after facial palsy onset regardless of ENoG value. In conclusion, ENoG value cannot predict when facial synkinesis develops in patients with facial palsy. We recommend that facial palsy patients with a high risk for the development of synkinesis begin the biofeedback rehabilitation with mirror to prevent the development of facial synkinesis 3 months after facial palsy onset. J. Med. Invest. 67 : 87-89, February, 2020."},"publication_date":"2020-02","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.67","number":"No.1.2","starting_page":"87","ending_page":"89","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.67.87"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/31280931","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=365513","label":"url"}],"paper_title":{"en":"Aural stimulation with capsaicin prevented pneumonia in dementia patients.","ja":"Aural stimulation with capsaicin prevented pneumonia in dementia patients."},"authors":{"en":[{"name":"Jinnouchi Osamu"},{"name":"Ohnishi Hiroki"},{"name":"Kondou Eiji"},{"name":"Kawata Ikuji"},{"name":"Bando Hiroyasu"},{"name":"Okamoto Hidehiko"},{"name":"Azuma Takahiro"},{"name":"Satou Gou"},{"name":"Kitamura Yoshiaki"},{"name":"Abe Koji"},{"name":"Takeda Noriaki"}],"ja":[{"name":"陣内 自治"},{"name":"大西 皓貴"},{"name":"近藤 英司"},{"name":"Kawata Ikuji"},{"name":"Bando Hiroyasu"},{"name":"Okamoto Hidehiko"},{"name":"東 貴弘"},{"name":"佐藤 豪"},{"name":"北村 嘉章"},{"name":"阿部 晃治"},{"name":"武田 憲昭"}]},"description":{"en":"These findings suggest that daily long-term aural stimulation with capsaicin ointment enhanced the cough reflex via Arnold's ear-cough reflex as a glottis protective measure, resulting in the reduction of incidence of pneumonia in elderly dementia patients at high risk of aspiration. The daily aural stimulation with capsaicin ointment may be a safe and promising intervention to prevent aspiration pneumonia in elderly people, especially those who cannot undergo swallowing exercise.","ja":"These findings suggest that daily long-term aural stimulation with capsaicin ointment enhanced the cough reflex via Arnold's ear-cough reflex as a glottis protective measure, resulting in the reduction of incidence of pneumonia in elderly dementia patients at high risk of aspiration. The daily aural stimulation with capsaicin ointment may be a safe and promising intervention to prevent aspiration pneumonia in elderly people, especially those who cannot undergo swallowing exercise."},"publication_date":"2020-02","publication_name":{"en":"Auris, Nasus, Larynx","ja":"Auris, Nasus, Larynx"},"volume":"Vol.47","number":"No.1","starting_page":"154","ending_page":"157","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.anl.2019.06.008"],"issn":["1879-1476"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/113985","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/30990106","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=365493","label":"url"}],"paper_title":{"en":"A new immunohistochemical method to evaluate the development of vestibular compensation after unilateral labyrinthectomy in rats.","ja":"A new immunohistochemical method to evaluate the development of vestibular compensation after unilateral labyrinthectomy in rats."},"authors":{"en":[{"name":"Matsuda Kazunori"},{"name":"Kitahara Tadashi"},{"name":"Ito Taeko"},{"name":"Fukushima Munehisa"},{"name":"Fukuda Junya"},{"name":"Satou Gou"},{"name":"Kitamura Yoshiaki"},{"name":"Abe Koji"},{"name":"Uno Atsuhiko"},{"name":"Tomita Koichi"},{"name":"Sakata-Haga Hiromi"},{"name":"Fukui Yoshihiro"},{"name":"Takeda Noriaki"}],"ja":[{"name":"松田 和徳"},{"name":"Kitahara Tadashi"},{"name":"Ito Taeko"},{"name":"Fukushima Munehisa"},{"name":"福田 潤弥"},{"name":"佐藤 豪"},{"name":"北村 嘉章"},{"name":"阿部 晃治"},{"name":"Uno Atsuhiko"},{"name":"冨田 江一"},{"name":"坂田 ひろみ"},{"name":"福井 義浩"},{"name":"武田 憲昭"}]},"description":{"en":"These findings suggested that the number of MK801-induced Fos-LIR neurons in contra-MVe was decreased in concordance with the restoration of ipsi-MVe-activity during the late process of VC after UL and that thioperamide accelerated the late, but not the initial process of VC.","ja":"These findings suggested that the number of MK801-induced Fos-LIR neurons in contra-MVe was decreased in concordance with the restoration of ipsi-MVe-activity during the late process of VC after UL and that thioperamide accelerated the late, but not the initial process of VC."},"publication_date":"2019-04-16","publication_name":{"en":"Acta Oto-Laryngologica","ja":"Acta Oto-Laryngologica"},"volume":"Vol.139","number":"No.6","starting_page":"505","ending_page":"510","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1080/00016489.2019.1599140"],"issn":["1651-2251"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://cir.nii.ac.jp/crid/1390283659826292992/","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-85077213217&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=365516","label":"url"}],"paper_title":{"en":"Effect of Surgical Training Using a Virtual Reality Temporal Bone Simulator in Medical Education","ja":"医学教育におけるバーチャルリアリティーを用いた側頭骨手術シミュレーション実習の効果"},"authors":{"en":[{"name":"Satou Gou"},{"name":"Kamimura Seiichiro"},{"name":"Kondou Eiji"},{"name":"Shimada Aki"},{"name":"Matsuda Kazunori"},{"name":"Azuma Takahiro"},{"name":"Kitamura Yoshiaki"},{"name":"Abe Koji"},{"name":"Takeda Noriaki"}],"ja":[{"name":"佐藤 豪"},{"name":"神村 盛一郎"},{"name":"近藤 英司"},{"name":"島田 亜紀"},{"name":"松田 和徳"},{"name":"東 貴弘"},{"name":"北村 嘉章"},{"name":"阿部 晃治"},{"name":"武田 憲昭"}]},"description":{"en":"To estimate the effects of a virtual reality temporal bone simulator in medical education.
Two hundred and thirty-five medical students undergoing bedside learning were recruited in this study for two years. The same instructor provided the training during the first year, while several instructors provided the training, based on a guidance manual, during the second year. We examined the students' knowledge of anatomy of the temporal bone and administered a questionnaire to determine their comprehension of surgical procedures involving the temporal bone after the training as compared to the level of understanding before the training.
The percentage of correct answers in the examination of anatomical knowledge about the temporal bone after the simulation in the first and second year improved from 51.8% to 83.9% and 49.4% to 80.0%, respectively. The percentages of medical students who responded with \"well understood\" or \"I think I understood\" to questions in the questionnaire on comprehension of surgical procedures involving the temporal bone in the first and second year were 84.3% and 76.4% for mastoidectomy, 74.8% and 66.4% for tympanotomy and 67.8% and 52.3% for cochleostomy, respectively. The anatomical and surgical comprehension levels, except for the case of cochleostomy, did not differ between students who received instructions from several instructors and those who received from the same instructor in this study. The training using a virtual reality temporal bone simulator was useful to improve the students' anatomical knowledge about the temporal bone and their comprehension of surgical procedures involving the temporal bone, and to unify the training content, regardless of the instructor because of standardization and customization of the surgical procedure. Thus, the training using a virtual reality temporal bone simulator is one of the most effective tools of medical education for both medical students and instructors.
","ja":"To estimate the effects of a virtual reality temporal bone simulator in medical education.
Two hundred and thirty-five medical students undergoing bedside learning were recruited in this study for two years. The same instructor provided the training during the first year, while several instructors provided the training, based on a guidance manual, during the second year. We examined the students' knowledge of anatomy of the temporal bone and administered a questionnaire to determine their comprehension of surgical procedures involving the temporal bone after the training as compared to the level of understanding before the training.
The percentage of correct answers in the examination of anatomical knowledge about the temporal bone after the simulation in the first and second year improved from 51.8% to 83.9% and 49.4% to 80.0%, respectively. The percentages of medical students who responded with \"well understood\" or \"I think I understood\" to questions in the questionnaire on comprehension of surgical procedures involving the temporal bone in the first and second year were 84.3% and 76.4% for mastoidectomy, 74.8% and 66.4% for tympanotomy and 67.8% and 52.3% for cochleostomy, respectively. The anatomical and surgical comprehension levels, except for the case of cochleostomy, did not differ between students who received instructions from several instructors and those who received from the same instructor in this study. The training using a virtual reality temporal bone simulator was useful to improve the students' anatomical knowledge about the temporal bone and their comprehension of surgical procedures involving the temporal bone, and to unify the training content, regardless of the instructor because of standardization and customization of the surgical procedure. Thus, the training using a virtual reality temporal bone simulator is one of the most effective tools of medical education for both medical students and instructors.
"},"publication_date":"2019","publication_name":{"en":"Journal of Otolaryngology of Japa","ja":"日本耳鼻咽喉科学会会報"},"volume":"Vol.122","number":"No.11","starting_page":"1423","ending_page":"1429","languages":["jpn"],"referee":true,"identifiers":{"doi":["10.3950/jibiinkoka.122.1423"],"issn":["0030-6622"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/114034","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/31656280","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=365497","label":"url"}],"paper_title":{"en":"Short-term pre-operative systemic administration with low-dose of steroid does not make a false-negative diagnosis of definite eosinophilic chronic rhinosinusitis after endoscopic sinus surgery.","ja":"Short-term pre-operative systemic administration with low-dose of steroid does not make a false-negative diagnosis of definite eosinophilic chronic rhinosinusitis after endoscopic sinus surgery."},"authors":{"en":[{"name":"Fujimoto Chisa"},{"name":"Tamura Koichi"},{"name":"Takaishi Shizuka"},{"name":"Kawata Ikuji"},{"name":"Kitamura Yoshiaki"},{"name":"Takeda Noriaki"}],"ja":[{"name":"藤本 知佐"},{"name":"田村 公一"},{"name":"Takaishi Shizuka"},{"name":"Kawata Ikuji"},{"name":"北村 嘉章"},{"name":"武田 憲昭"}]},"description":{"en":"According to JESREC criteria, definite eosinophilic chronic rhinosinusitis (ECRS) is postoperatively diagnosed based on over 70 eosinophils in high power magnification fields of the resected nasal polyps in patients with probable ECRS. Preoperative systemic administration with steroid is a standard practice, because it reduced intraoperative bleeding during endoscopic sinus surgery (ESS) in patients with ECRS. However, it was recently reported that systemic administration with steroid decreased the number of eosinophils in the nasal polyps, leading to a false negative diagnosis of definite ECRS. To overcome the risk, we have adopted short-term pre-operative systemic administration with low-dose of steroid and examined if our steroid administration makes a false-negative diagnosis. We performed a retrospective chart review of 42 patients with probable ECRS. Eleven patients were administered with 0.5 mg of bethametasone for 7 days before ESS, and other 31 patients were not administered. The average number of eosinophils in nasal polyps in patients who were administered with steroid was 188 ± 167, which was not different from 199 ± 149 in the patients who were not administered. These findings suggest that short-term preoperative administration with low-dose of steroid has few risk of a false-negative diagnosis of definite ECRS. J. Med. Invest. 66 : 233-236, August, 2019.","ja":"According to JESREC criteria, definite eosinophilic chronic rhinosinusitis (ECRS) is postoperatively diagnosed based on over 70 eosinophils in high power magnification fields of the resected nasal polyps in patients with probable ECRS. Preoperative systemic administration with steroid is a standard practice, because it reduced intraoperative bleeding during endoscopic sinus surgery (ESS) in patients with ECRS. However, it was recently reported that systemic administration with steroid decreased the number of eosinophils in the nasal polyps, leading to a false negative diagnosis of definite ECRS. To overcome the risk, we have adopted short-term pre-operative systemic administration with low-dose of steroid and examined if our steroid administration makes a false-negative diagnosis. We performed a retrospective chart review of 42 patients with probable ECRS. Eleven patients were administered with 0.5 mg of bethametasone for 7 days before ESS, and other 31 patients were not administered. The average number of eosinophils in nasal polyps in patients who were administered with steroid was 188 ± 167, which was not different from 199 ± 149 in the patients who were not administered. These findings suggest that short-term preoperative administration with low-dose of steroid has few risk of a false-negative diagnosis of definite ECRS. J. Med. Invest. 66 : 233-236, August, 2019."},"publication_date":"2019","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.66","number":"No.3.4","starting_page":"233","ending_page":"236","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.66.233"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/112928","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/30301597","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=353059","label":"url"}],"paper_title":{"en":"Effects of irradiation with narrowband-ultraviolet B on up-regulation of histamine H1 receptor mRNA and induction of apoptosis in HeLa cells and nasal mucosa of rats.","ja":"Effects of irradiation with narrowband-ultraviolet B on up-regulation of histamine H1 receptor mRNA and induction of apoptosis in HeLa cells and nasal mucosa of rats."},"authors":{"en":[{"name":"Fujii Tatsuya"},{"name":"Kitamura Yoshiaki"},{"name":"Mizuguchi Hiroyuki"},{"name":"Okamoto Kentaroh"},{"name":"Sanada Nanae"},{"name":"Yamada Takuya"},{"name":"Sugiyama Manabu"},{"name":"Michinaga Shotaro"},{"name":"Kitayama Mika"},{"name":"Fukui Hiroyuki"},{"name":"Takeda Noriaki"}],"ja":[{"name":"藤井 達也"},{"name":"北村 嘉章"},{"name":"水口 博之"},{"name":"Okamoto Kentaroh"},{"name":"Sanada Nanae"},{"name":"Yamada Takuya"},{"name":"Sugiyama Manabu"},{"name":"Michinaga Shotaro"},{"name":"Kitayama Mika"},{"name":"福井 裕行"},{"name":"武田 憲昭"}]},"description":{"en":"once a day for three days suppressed TDI-induced sneezes and up-regulation of H1R mRNA in nasal mucosa without induction of apoptosis. These findings suggest that repeated intranasal irradiation with low dose of NB-UVB could be clinically used as phototherapy of AR.","ja":", irradiation with 310 nm NB-UVB induced apoptosis. Western blot analysis showed that the suppressive effect of NB-UVB irradiation on H1R gene expression was through the inhibition of ERK phosphorylation. In TDI-sensitized rat, intranasal irradiation with 310 nm NB-UVB at an estimated dose of 100 mJ/cm"},"publication_date":"2018-09-10","publication_name":{"en":"Journal of Pharmacological Sciences","ja":"Journal of Pharmacological Sciences"},"volume":"Vol.138","number":"No.1","starting_page":"54","ending_page":"62","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.jphs.2018.08.011"],"issn":["1347-8648"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/30175778","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=353061","label":"url"}],"paper_title":{"en":"Receptor and Interleukin-9 Gene Expressions Responsible for the Pathogenesis of the Allergic Rhinitis.","ja":"Receptor and Interleukin-9 Gene Expressions Responsible for the Pathogenesis of the Allergic Rhinitis."},"authors":{"en":[{"name":"Shaha Aurpita"},{"name":"Mizuguchi Hiroyuki"},{"name":"Kitamura Yoshiaki"},{"name":"Fujino Hiromichi"},{"name":"Yabumoto Masami"},{"name":"Takeda Noriaki"},{"name":"Fukui Hiroyuki"}],"ja":[{"name":"Shaha Aurpita"},{"name":"水口 博之"},{"name":"北村 嘉章"},{"name":"藤野 裕道"},{"name":"Yabumoto Masami"},{"name":"武田 憲昭"},{"name":"福井 裕行"}]},"description":{"en":"phosphorylation of PKCδ in HeLa cells. In RBL-2H3 cells, RJ and BGPP also suppressed NFAT-mediated IL-9 gene expression. These results suggest that RJ and BGPP improve allergic symptoms by suppressing PKCδ and NFAT signaling pathways, two important signal pathways for the AR pathogenesis, and suggest that RJ and BGPP could be good therapeutics against AR.","ja":"phosphorylation of PKCδ in HeLa cells. In RBL-2H3 cells, RJ and BGPP also suppressed NFAT-mediated IL-9 gene expression. These results suggest that RJ and BGPP improve allergic symptoms by suppressing PKCδ and NFAT signaling pathways, two important signal pathways for the AR pathogenesis, and suggest that RJ and BGPP could be good therapeutics against AR."},"publication_date":"2018","publication_name":{"en":"Biological & Pharmaceutical Bulletin","ja":"Biological & Pharmaceutical Bulletin"},"volume":"Vol.41","number":"No.9","starting_page":"1440","ending_page":"1447","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1248/bpb.b18-00325"],"issn":["1347-5215"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/112246","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/30282868","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=353060","label":"url"}],"paper_title":{"en":"Effect of wild grape on the signaling of histamine H1 receptor gene expression responsible for the pathogenesis of allergic rhinitis.","ja":"Effect of wild grape on the signaling of histamine H1 receptor gene expression responsible for the pathogenesis of allergic rhinitis."},"authors":{"en":[{"name":"Islam Rezwanul"},{"name":"Mizuguchi Hiroyuki"},{"name":"Shaha Aurpita"},{"name":"Nishida Kohei"},{"name":"Yabumoto Masami"},{"name":"Ikeda Hisashi"},{"name":"Fujino Hiromichi"},{"name":"Kitamura Yoshiaki"},{"name":"Fukui Hiroyuki"},{"name":"Takeda Noriaki"}],"ja":[{"name":"Islam Rezwanul"},{"name":"水口 博之"},{"name":"Shaha Aurpita"},{"name":"Nishida Kohei"},{"name":"Yabumoto Masami"},{"name":"Ikeda Hisashi"},{"name":"藤野 裕道"},{"name":"北村 嘉章"},{"name":"福井 裕行"},{"name":"武田 憲昭"}]},"description":{"en":"receptor (H1R) and IL-9 gene expressions, respectively, are responsible for the pathogenesis of allergic rhinitis. We explore anti-allergic compounds that suppress these signaling pathways and found that wild grape (WG) contains such compounds. Here, we investigated the effect of WG hot water extract (WGE) on the signaling pathways for PKCδ-mediated H1R and NFAT-mediated IL-9 gene expressions. WGE suppressed histamine/PMA-induced H1R gene up-regulation in HeLa cells. Toluene-2,4-diisocyanate (TDI)-induced H1R mRNA elevation in TDI-sensitized rats was also suppressed by WGE treatment. Treatment with WGE in combination with Awa-tea, suppresses NFAT signaling-mediated IL-9 gene, markedly alleviated nasal symptoms. Furthermore, WGE suppressed PMA-induced IL-33 gene up-regulation in Swiss 3T3 cells. Data suggest that combination of WGE, suppresses PKCδ signaling with Awa-tea, suppresses NFAT signaling would have distinct clinical and therapeutic advantages as a substitute for anti-allergic drugs. In addition, as the expression level of IL-33 mRNA was correlated with the blood eosinophils number in patients with pollinosis, WG could alleviate eosinophilic inflammation through the suppression of IL-33 gene expression. J. Med. Invest. 65:242-250, August, 2018.","ja":"receptor (H1R) and IL-9 gene expressions, respectively, are responsible for the pathogenesis of allergic rhinitis. We explore anti-allergic compounds that suppress these signaling pathways and found that wild grape (WG) contains such compounds. Here, we investigated the effect of WG hot water extract (WGE) on the signaling pathways for PKCδ-mediated H1R and NFAT-mediated IL-9 gene expressions. WGE suppressed histamine/PMA-induced H1R gene up-regulation in HeLa cells. Toluene-2,4-diisocyanate (TDI)-induced H1R mRNA elevation in TDI-sensitized rats was also suppressed by WGE treatment. Treatment with WGE in combination with Awa-tea, suppresses NFAT signaling-mediated IL-9 gene, markedly alleviated nasal symptoms. Furthermore, WGE suppressed PMA-induced IL-33 gene up-regulation in Swiss 3T3 cells. Data suggest that combination of WGE, suppresses PKCδ signaling with Awa-tea, suppresses NFAT signaling would have distinct clinical and therapeutic advantages as a substitute for anti-allergic drugs. In addition, as the expression level of IL-33 mRNA was correlated with the blood eosinophils number in patients with pollinosis, WG could alleviate eosinophilic inflammation through the suppression of IL-33 gene expression. J. Med. Invest. 65:242-250, August, 2018."},"publication_date":"2018","publication_name":{"en":"The Journal of Medical Investigation : JMI","ja":"The Journal of Medical Investigation : JMI"},"volume":"Vol.65","number":"No.3.4","starting_page":"242","ending_page":"250","languages":["eng"],"referee":true,"identifiers":{"doi":["10.2152/jmi.65.242"],"issn":["1349-6867"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/27319356","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=328062","label":"url"}],"paper_title":{"en":"Effects of repeated snowboard exercise in virtual reality with time lags of visual scene behind body rotation on head stability and subjective slalom run performance in healthy young subjects","ja":"Effects of repeated snowboard exercise in virtual reality with time lags of visual scene behind body rotation on head stability and subjective slalom run performance in healthy young subjects"},"authors":{"en":[{"name":"Wada Yoshiro"},{"name":"Nishiike Suetaka"},{"name":"Kitahara Tadashi"},{"name":"Yamanaka Toshiaki"},{"name":"Imai Takao"},{"name":"Ito Taeko"},{"name":"Satou Gou"},{"name":"Matsuda Kazunori"},{"name":"Kitamura Yoshiaki"},{"name":"Takeda Noriaki"}],"ja":[{"name":"Wada Yoshiro"},{"name":"Nishiike Suetaka"},{"name":"Kitahara Tadashi"},{"name":"Yamanaka Toshiaki"},{"name":"Imai Takao"},{"name":"Ito Taeko"},{"name":"佐藤 豪"},{"name":"松田 和徳"},{"name":"北村 嘉章"},{"name":"武田 憲昭"}]},"description":{"en":"After repeated snowboard exercises in the virtual reality (VR) world with increasing time lags in trials 3-8, it is suggested that the adaptation to repeated visual-vestibulosomatosensory conflict in the VR world improved dynamic posture control and motor performance in the real world without the development of motion sickness. The VR technology was used and the effects of repeated snowboard exercise examined in the VR world with time lags between visual scene and body rotation on the head stability and slalom run performance during exercise in healthy subjects. Forty-two healthy young subjects participated in the study. After trials 1 and 2 of snowboard exercise in the VR world without time lag, trials 3-8 were conducted with 0.1, 0.2, 0.3, 0.4, 0.5, and 0.6 s time lags of the visual scene that the computer creates behind board rotation, respectively. Finally, trial 9 was conducted without time lag. Head linear accelerations and subjective slalom run performance were evaluated. The standard deviations of head linear accelerations in inter-aural direction were significantly increased in trial 8, with a time lag of 0.6 s, but significantly decreased in trial 9 without a time lag, compared with those in trial 2 without a time lag. The subjective scores of slalom run performance were significantly decreased in trial 8, with a time lag of 0.6 s, but significantly increased in trial 9 without a time lag, compared with those in trial 2 without a time lag. Motion sickness was not induced in any subjects.","ja":"After repeated snowboard exercises in the virtual reality (VR) world with increasing time lags in trials 3-8, it is suggested that the adaptation to repeated visual-vestibulosomatosensory conflict in the VR world improved dynamic posture control and motor performance in the real world without the development of motion sickness. The VR technology was used and the effects of repeated snowboard exercise examined in the VR world with time lags between visual scene and body rotation on the head stability and slalom run performance during exercise in healthy subjects. Forty-two healthy young subjects participated in the study. After trials 1 and 2 of snowboard exercise in the VR world without time lag, trials 3-8 were conducted with 0.1, 0.2, 0.3, 0.4, 0.5, and 0.6 s time lags of the visual scene that the computer creates behind board rotation, respectively. Finally, trial 9 was conducted without time lag. Head linear accelerations and subjective slalom run performance were evaluated. The standard deviations of head linear accelerations in inter-aural direction were significantly increased in trial 8, with a time lag of 0.6 s, but significantly decreased in trial 9 without a time lag, compared with those in trial 2 without a time lag. The subjective scores of slalom run performance were significantly decreased in trial 8, with a time lag of 0.6 s, but significantly increased in trial 9 without a time lag, compared with those in trial 2 without a time lag. Motion sickness was not induced in any subjects."},"publication_date":"2016-07-20","publication_name":{"en":"Acta Oto-Laryngologica","ja":"Acta Oto-Laryngologica"},"volume":"Vol.136","number":"No.11","starting_page":"1121","ending_page":"1124","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1080/00016489.2016.1193890"],"issn":["1651-2251"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/26824787","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=320813","label":"url"}],"paper_title":{"en":"Irradiation with narrowband-ultraviolet B suppresses phorbol ester-induced up-regulation of H1 receptor mRNA in HeLa cells","ja":"Irradiation with narrowband-ultraviolet B suppresses phorbol ester-induced up-regulation of H1 receptor mRNA in HeLa cells"},"authors":{"en":[{"name":"Kitamura Yoshiaki"},{"name":"Mizuguchi Hiroyuki"},{"name":"Okamoto Kentaro"},{"name":"Kitayama, Mika"},{"name":"Fujii Tatsuya"},{"name":"Fujioka, Akira"},{"name":"Matsushita Toshio"},{"name":"Mukai Takashi"},{"name":"Kubo Yoshiaki"},{"name":"Kubo Nobuo"},{"name":"Fukui Hiroyuki"},{"name":"Takeda Noriaki"}],"ja":[{"name":"北村 嘉章"},{"name":"水口 博之"},{"name":"Okamoto Kentaro"},{"name":"Kitayama, Mika"},{"name":"藤井 達也"},{"name":"Fujioka, Akira"},{"name":"Matsushita Toshio"},{"name":"向井 孝志"},{"name":"久保 宜明"},{"name":"Kubo Nobuo"},{"name":"福井 裕行"},{"name":"武田 憲昭"}]},"description":{"en":"Conclusion These findings suggest that low dose irradiation with 310 nm NB-UVB specifically suppressed the up-regulation of H1R gene expression without inducing apoptosis and that UVB of shorter or longer wavelength than 310 nm NB-UVB had no such effects. Objective To develop a narrowband-ultraviolet B(NB-UVB) phototherapy for allergic rhinitis, this study investigated the effects of irradiation with NB-UVB at wavelength of 310 nm on phorbol-12-myristate-13-acetate (PMA)-induced up-regulation of histamine H1 receptor (H1R) mRNA in HeLa cells. Methods The mRNA levels of H1R in HeLa cells were measured using real-time RT-PCR. Apoptosis were evaluated with DNA fragmentation assay. Results PMA induced a significant increase in H1R mRNA expression in HeLa cells. Irradiation with 305 nm UVB and 310 nm NB-UVB, but not with 315 nm UVB at doses of 200 and 300 mJ/cm(2) significantly suppressed PMA-induced up-regulation of H1R mRNA. At a dose of 200 mJ/cm(2), irradiation with 305 nm UVB, but not with 310 nm NB-UVB, induced apoptosis, although exposure of the cells to both 305 and 310 nm UVB induced apoptosis at a dose of 300 mJ/cm(2) after PMA treatment in HeLa cells. Conversely, irradiation with 315 nm UVB at doses of 200 and 300 mJ/cm(2) did not induce apoptosis.","ja":"Conclusion These findings suggest that low dose irradiation with 310 nm NB-UVB specifically suppressed the up-regulation of H1R gene expression without inducing apoptosis and that UVB of shorter or longer wavelength than 310 nm NB-UVB had no such effects. Objective To develop a narrowband-ultraviolet B(NB-UVB) phototherapy for allergic rhinitis, this study investigated the effects of irradiation with NB-UVB at wavelength of 310 nm on phorbol-12-myristate-13-acetate (PMA)-induced up-regulation of histamine H1 receptor (H1R) mRNA in HeLa cells. Methods The mRNA levels of H1R in HeLa cells were measured using real-time RT-PCR. Apoptosis were evaluated with DNA fragmentation assay. Results PMA induced a significant increase in H1R mRNA expression in HeLa cells. Irradiation with 305 nm UVB and 310 nm NB-UVB, but not with 315 nm UVB at doses of 200 and 300 mJ/cm(2) significantly suppressed PMA-induced up-regulation of H1R mRNA. At a dose of 200 mJ/cm(2), irradiation with 305 nm UVB, but not with 310 nm NB-UVB, induced apoptosis, although exposure of the cells to both 305 and 310 nm UVB induced apoptosis at a dose of 300 mJ/cm(2) after PMA treatment in HeLa cells. Conversely, irradiation with 315 nm UVB at doses of 200 and 300 mJ/cm(2) did not induce apoptosis."},"publication_date":"2016-04","publication_name":{"en":"Acta Oto-Laryngologica","ja":"Acta Oto-Laryngologica"},"volume":"Vol.136","number":"No.4","starting_page":"409","ending_page":"413","languages":["eng"],"referee":true,"identifiers":{"doi":["10.3109/00016489.2015.1129555"],"issn":["1651-2251"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/113027","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/26980430","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-84960076791&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=311115","label":"url"}],"paper_title":{"en":"Antihistamines suppress upregulation of histidine decarboxylase gene expression with potencies different from their binding affinities for histamine H1 receptor in toluene 2,4-diisocyanate-sensitized rats.","ja":"Antihistamines suppress upregulation of histidine decarboxylase gene expression with potencies different from their binding affinities for histamine H1 receptor in toluene 2,4-diisocyanate-sensitized rats."},"authors":{"en":[{"name":"Mizuguchi Hiroyuki"},{"name":"Das AK"},{"name":"Maeyama Kazutaka"},{"name":"Dev S"},{"name":"Shahriar M"},{"name":"Kitamura Yoshiaki"},{"name":"Takeda Noriaki"},{"name":"Fukui Hiroyuki"}],"ja":[{"name":"水口 博之"},{"name":"Das AK"},{"name":"前山 一隆"},{"name":"Dev S"},{"name":"Shahriar M"},{"name":"北村 嘉章"},{"name":"武田 憲昭"},{"name":"福井 裕行"}]},"description":{"en":"Antihistamines inhibit histamine signaling by blocking histamine H1 receptor (H1R) or suppressing H1R signaling as inverse agonists. The H1R gene is upregulated in patients with pollinosis, and its expression level is correlated with the severity of nasal symptoms. Here, we show that antihistamine suppressed upregulation of histidine decarboxylase (HDC) mRNA expression in patients with pollinosis, and its expression level was correlated with that of H1R mRNA. Certain antihistamines, including mepyramine and diphenhydramine, suppress toluene-2,4-diisocyanate (TDI)-induced upregulation of HDC gene expression and increase HDC activity in TDI-sensitized rats. However, d-chlorpheniramine did not demonstrate any effect. The potencies of antihistamine suppressive effects on HDC mRNA elevation were different from their H1R receptor binding affinities. In TDI-sensitized rats, the potencies of antihistamine inhibitory effects on sneezing in the early phase were related to H1R binding. In contrast, the potencies of their inhibitory effects on sneezing in the late phase were correlated with those of suppressive effects on HDC mRNA elevation. Data suggest that in addition to the antihistaminic and inverse agonistic activities, certain antihistamines possess additional properties unrelated to receptor binding and alleviate nasal symptoms in the late phase by inhibiting synthesis and release of histamine by suppressing HDC gene transcription.","ja":"Antihistamines inhibit histamine signaling by blocking histamine H1 receptor (H1R) or suppressing H1R signaling as inverse agonists. The H1R gene is upregulated in patients with pollinosis, and its expression level is correlated with the severity of nasal symptoms. Here, we show that antihistamine suppressed upregulation of histidine decarboxylase (HDC) mRNA expression in patients with pollinosis, and its expression level was correlated with that of H1R mRNA. Certain antihistamines, including mepyramine and diphenhydramine, suppress toluene-2,4-diisocyanate (TDI)-induced upregulation of HDC gene expression and increase HDC activity in TDI-sensitized rats. However, d-chlorpheniramine did not demonstrate any effect. The potencies of antihistamine suppressive effects on HDC mRNA elevation were different from their H1R receptor binding affinities. In TDI-sensitized rats, the potencies of antihistamine inhibitory effects on sneezing in the early phase were related to H1R binding. In contrast, the potencies of their inhibitory effects on sneezing in the late phase were correlated with those of suppressive effects on HDC mRNA elevation. Data suggest that in addition to the antihistaminic and inverse agonistic activities, certain antihistamines possess additional properties unrelated to receptor binding and alleviate nasal symptoms in the late phase by inhibiting synthesis and release of histamine by suppressing HDC gene transcription."},"publication_date":"2016-02-11","publication_name":{"en":"Journal of Pharmacological Sciences","ja":"Journal of Pharmacological Sciences"},"volume":"Vol.130","number":"No.4","starting_page":"212","ending_page":"218","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.jphs.2016.02.002"],"issn":["1347-8648"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/113026","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/26874672","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=311114","label":"url"}],"paper_title":{"en":"Suplatast tosilate alleviates nasal symptoms through the suppression of nuclear factor of activated T-cells-mediated IL-9 gene expression in toluene-2,4-diisocyanate-sensitized rats.","ja":"Suplatast tosilate alleviates nasal symptoms through the suppression of nuclear factor of activated T-cells-mediated IL-9 gene expression in toluene-2,4-diisocyanate-sensitized rats."},"authors":{"en":[{"name":"Mizuguchi Hiroyuki"},{"name":"Orimoto N"},{"name":"Kadota T"},{"name":"Kominami T"},{"name":"Das AK"},{"name":"Sawada A"},{"name":"Tamada M"},{"name":"Miyagi K"},{"name":"Adachi T"},{"name":"Matsumoto M"},{"name":"Kosaka T"},{"name":"Kitamura Yoshiaki"},{"name":"Takeda Noriaki"},{"name":"Fukui Hiroyuki"}],"ja":[{"name":"水口 博之"},{"name":"Orimoto N"},{"name":"Kadota T"},{"name":"Kominami T"},{"name":"Das AK"},{"name":"Sawada A"},{"name":"Tamada M"},{"name":"Miyagi K"},{"name":"Adachi T"},{"name":"Matsumoto M"},{"name":"Kosaka T"},{"name":"北村 嘉章"},{"name":"武田 憲昭"},{"name":"福井 裕行"}]},"description":{"en":"Histamine H1 receptor (H1R) gene is upregulated in patients with pollinosis; its expression level is highly correlated with the nasal symptom severity. Antihistamines are widely used as allergy treatments because they inhibit histamine signaling by blocking H1R or suppressing H1R signaling as inverse agonists. However, long-term treatment with antihistamines does not completely resolve toluene-2,4-diisocyanate (TDI)-induced nasal symptoms, although it can decrease H1R gene expression to the basal level, suggesting additional signaling is responsible for the pathogenesis of the allergic symptoms. Here, we show that treatment with suplatast tosilate in combination with antihistamines markedly alleviates nasal symptoms in TDI-sensitized rats. Suplatast suppressed TDI-induced upregulation of IL-9 gene expression. Suplatast also suppressed ionomycin/phorbol-12-myristate-13-acetate-induced upregulation of IL-2 gene expression in Jurkat cells, in which calcineurin (CN)/nuclear factor of activated T-cells (NFAT) signaling is known to be involved. Immunoblot analysis demonstrated that suplatast inhibited binding of NFAT to DNA. Furthermore, suplatast suppressed ionomycin-induced IL-9 mRNA upregulation in RBL-2H3 cells, in which CN/NFAT signaling is also involved. These data suggest that suplatast suppressed NFAT-mediated IL-9 gene expression in TDI-sensitized rats and this might be the underlying mechanism of the therapeutic effects of combined therapy of suplatast with antihistamine.","ja":"Histamine H1 receptor (H1R) gene is upregulated in patients with pollinosis; its expression level is highly correlated with the nasal symptom severity. Antihistamines are widely used as allergy treatments because they inhibit histamine signaling by blocking H1R or suppressing H1R signaling as inverse agonists. However, long-term treatment with antihistamines does not completely resolve toluene-2,4-diisocyanate (TDI)-induced nasal symptoms, although it can decrease H1R gene expression to the basal level, suggesting additional signaling is responsible for the pathogenesis of the allergic symptoms. Here, we show that treatment with suplatast tosilate in combination with antihistamines markedly alleviates nasal symptoms in TDI-sensitized rats. Suplatast suppressed TDI-induced upregulation of IL-9 gene expression. Suplatast also suppressed ionomycin/phorbol-12-myristate-13-acetate-induced upregulation of IL-2 gene expression in Jurkat cells, in which calcineurin (CN)/nuclear factor of activated T-cells (NFAT) signaling is known to be involved. Immunoblot analysis demonstrated that suplatast inhibited binding of NFAT to DNA. Furthermore, suplatast suppressed ionomycin-induced IL-9 mRNA upregulation in RBL-2H3 cells, in which CN/NFAT signaling is also involved. These data suggest that suplatast suppressed NFAT-mediated IL-9 gene expression in TDI-sensitized rats and this might be the underlying mechanism of the therapeutic effects of combined therapy of suplatast with antihistamine."},"publication_date":"2016-01-06","publication_name":{"en":"Journal of Pharmacological Sciences","ja":"Journal of Pharmacological Sciences"},"volume":"Vol.130","number":"No.3","starting_page":"151","ending_page":"158","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.jphs.2015.12.008"],"issn":["1347-8648"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/26619301","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-84948402928&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=311109","label":"url"}],"paper_title":{"en":"A novel benzofuran, 4-methoxybenzofuran-5-carboxamide, from Tephrosia purpurea suppressed histamine H1 receptor gene expression through a protein kinase C--dependent signaling pathway.","ja":"A novel benzofuran, 4-methoxybenzofuran-5-carboxamide, from Tephrosia purpurea suppressed histamine H1 receptor gene expression through a protein kinase C--dependent signaling pathway."},"authors":{"en":[{"name":"Shill Chandra Manik"},{"name":"Mizuguchi Hiroyuki"},{"name":"Karmakar Sanmoy"},{"name":"Kadota Takuya"},{"name":"Mukherjee K. Pulok"},{"name":"Kashiwada Yoshiki"},{"name":"Kitamura Yoshiaki"},{"name":"Nemoto Hisao"},{"name":"Takeda Noriaki"},{"name":"Fukui Hiroyuki"}],"ja":[{"name":"Shill Chandra Manik"},{"name":"水口 博之"},{"name":"Karmakar Sanmoy"},{"name":"Kadota Takuya"},{"name":"Mukherjee K. Pulok"},{"name":"柏田 良樹"},{"name":"北村 嘉章"},{"name":"根本 尚夫"},{"name":"武田 憲昭"},{"name":"福井 裕行"}]},"description":{"en":"Histamine H1 receptor (H1R) gene is upregulated in patients with allergic rhinitis (AR), and its expression level is strongly correlated with the severity of allergic symptoms. We previously reported isolation of the putative anti-allergic compound, 4-methoxybenzofuran-5-carboxamide (MBCA) from Tephrosia purpurea and its chemical synthesis (Shill et al., Bioorg Med Chem 2015;23:6869-6874). However, the mechanism underlying its anti-allergic activity remains to be elucidated. Here, we report the mechanism of MBCA on phorbol 12-myristate-13-acetate (PMA)- or histamine-induced upregulation of H1R gene expression in HeLa cells, and in vivo effects of MBCA were also determined in toluene-2,4-diisocyanate (TDI)-sensitized rats. MBCA suppressed PMA- and histamine-induced upregulation of H1R expression at both mRNA and protein levels and inhibited PMA-induced phosphorylation of PKCδ at Tyr(311) and subsequent translocation to the Golgi. Furthermore, MBCA ameliorated allergic symptoms and suppressed the elevation of H1R and helper T cell type 2 (Th2) cytokine mRNAs in TDI-sensitized rats. Data suggest that MBCA alleviates nasal symptoms in TDI-sensitized rats through the inhibition of H1R and Th2 cytokine gene expression. The mechanism of its H1R gene suppression underlies the inhibition of PKCδ activation.","ja":"Histamine H1 receptor (H1R) gene is upregulated in patients with allergic rhinitis (AR), and its expression level is strongly correlated with the severity of allergic symptoms. We previously reported isolation of the putative anti-allergic compound, 4-methoxybenzofuran-5-carboxamide (MBCA) from Tephrosia purpurea and its chemical synthesis (Shill et al., Bioorg Med Chem 2015;23:6869-6874). However, the mechanism underlying its anti-allergic activity remains to be elucidated. Here, we report the mechanism of MBCA on phorbol 12-myristate-13-acetate (PMA)- or histamine-induced upregulation of H1R gene expression in HeLa cells, and in vivo effects of MBCA were also determined in toluene-2,4-diisocyanate (TDI)-sensitized rats. MBCA suppressed PMA- and histamine-induced upregulation of H1R expression at both mRNA and protein levels and inhibited PMA-induced phosphorylation of PKCδ at Tyr(311) and subsequent translocation to the Golgi. Furthermore, MBCA ameliorated allergic symptoms and suppressed the elevation of H1R and helper T cell type 2 (Th2) cytokine mRNAs in TDI-sensitized rats. Data suggest that MBCA alleviates nasal symptoms in TDI-sensitized rats through the inhibition of H1R and Th2 cytokine gene expression. The mechanism of its H1R gene suppression underlies the inhibition of PKCδ activation."},"publication_date":"2016-01","publication_name":{"en":"International Immunopharmacology","ja":"International Immunopharmacology"},"volume":"Vol.30","starting_page":"18","ending_page":"26","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.intimp.2015.11.021"],"issn":["1878-1705"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/109692","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/26598006","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=311106","label":"url"}],"paper_title":{"en":"Effects of antihistamine on up-regulation of histamine H1 receptor mRNA in the nasal mucosa of patients with pollinosis induced by controlled cedar pollen challenge in an environmental exposure unit.","ja":"Effects of antihistamine on up-regulation of histamine H1 receptor mRNA in the nasal mucosa of patients with pollinosis induced by controlled cedar pollen challenge in an environmental exposure unit."},"authors":{"en":[{"name":"Kitamura Yoshiaki"},{"name":"Nakagawa H"},{"name":"Fujii Tatsuya"},{"name":"Sakoda T"},{"name":"Enomoto T"},{"name":"Mizuguchi Hiroyuki"},{"name":"Fukui Hiroyuki"},{"name":"Takeda Noriaki"}],"ja":[{"name":"北村 嘉章"},{"name":"Nakagawa H"},{"name":"藤井 達也"},{"name":"Sakoda T"},{"name":"Enomoto T"},{"name":"水口 博之"},{"name":"福井 裕行"},{"name":"武田 憲昭"}]},"description":{"en":"In the present study, we examined the effects of antihistamine on the up-regulation of H1R mRNA in the nasal mucosa of patients with pollinosis induced by controlled exposure to pollen using an environmental exposure unit. Out of 20 patients, we designated 14 responders, whose levels of H1R mRNA in the nasal mucosa were increased after the first pollen exposure and excluded 6 non-responders. Accordingly, the first exposure to pollen without treatment significantly induced both nasal symptoms and the up-regulation of H1R mRNA in the nasal mucosa of the responders. Subsequently, prophylactic administration of antihistamine prior to the second pollen exposure significantly inhibited both of the above effects in the responders. Moreover, the nasal expression of H1R mRNA before the second pollen exposure in the responders pretreated with antihistamine was significantly decreased, as compared with that before the first pollen exposure without treatment. These findings suggest that antihistamines suppressed histamine-induced transcriptional activation of H1R gene in the nasal mucosa, in addition to their blocking effect against histamine on H1R, resulting in a decrease of nasal symptoms. These findings further suggest that by their inverse agonistic activity, antihistamines suppress the basal transcription of nasal H1R in the absence of histamine in responders.","ja":"In the present study, we examined the effects of antihistamine on the up-regulation of H1R mRNA in the nasal mucosa of patients with pollinosis induced by controlled exposure to pollen using an environmental exposure unit. Out of 20 patients, we designated 14 responders, whose levels of H1R mRNA in the nasal mucosa were increased after the first pollen exposure and excluded 6 non-responders. Accordingly, the first exposure to pollen without treatment significantly induced both nasal symptoms and the up-regulation of H1R mRNA in the nasal mucosa of the responders. Subsequently, prophylactic administration of antihistamine prior to the second pollen exposure significantly inhibited both of the above effects in the responders. Moreover, the nasal expression of H1R mRNA before the second pollen exposure in the responders pretreated with antihistamine was significantly decreased, as compared with that before the first pollen exposure without treatment. These findings suggest that antihistamines suppressed histamine-induced transcriptional activation of H1R gene in the nasal mucosa, in addition to their blocking effect against histamine on H1R, resulting in a decrease of nasal symptoms. These findings further suggest that by their inverse agonistic activity, antihistamines suppress the basal transcription of nasal H1R in the absence of histamine in responders."},"publication_date":"2015-10-30","publication_name":{"en":"Journal of Pharmacological Sciences","ja":"Journal of Pharmacological Sciences"},"volume":"Vol.129","number":"No.3","starting_page":"183","ending_page":"187","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1016/j.jphs.2015.10.007"],"issn":["1347-8648"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/26422579","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=319396","label":"url"}],"paper_title":{"en":"Effects of chemotherapy on gene expression of lingual taste receptors in patients with head and neck cancer.","ja":"Effects of chemotherapy on gene expression of lingual taste receptors in patients with head and neck cancer."},"authors":{"en":[{"name":"Tsutsumi Rie"},{"name":"Goda Masakazu"},{"name":"Fujimoto Chisa"},{"name":"Kanno Kyoko"},{"name":"Nobe Misaki"},{"name":"Kitamura Yoshiaki"},{"name":"Abe Koji"},{"name":"Kawai Misako"},{"name":"Matsumoto Hideki"},{"name":"Sakai Tohru"},{"name":"Takeda Noriaki"}],"ja":[{"name":"堤 理恵"},{"name":"合田 正和"},{"name":"藤本 知佐"},{"name":"神農 今日子"},{"name":"Nobe Misaki"},{"name":"北村 嘉章"},{"name":"阿部 晃治"},{"name":"Kawai Misako"},{"name":"Matsumoto Hideki"},{"name":"酒井 徹"},{"name":"武田 憲昭"}]},"description":{"en":"We aimed to test the hypothesis that chemotherapy changes the gene expression of taste receptors in the tongue to induce dysgeusia in patients with head and neck cancer. Prospective observation study. We enrolled 21 patients who received chemoradiotherapy and five patients who underwent radiotherapy for head and neck cancer. The messenger RNA (mRNA) levels of the taste receptor subunits T1R1, T1R2, T1R3, and T2R5 were measured in lingual mucosa scrapings obtained with a small spatula. The perception thresholds of umami, sweet, and bitter tastes were assessed by the whole mouth gustatory test. In four patients with severe stomatitis induced by chemoradiotherapy, the mRNA levels of T1R1, T1R2, T1R3, and T2R5 in the lingual mucosa were significantly decreased. However, in 17 patients with mild/moderate stomatitis, the mRNA levels of T1R3 were significantly and transiently decreased, whereas those of T1R1 and T1R2 remained unchanged and those of T2R5 mRNA were significantly and transiently increased after chemotherapy. There was a significant negative correlation between the perception thresholds of umami or sweet tastes and lingual mRNA levels of T1R3 in patients with mild/moderate stomatitis after chemotherapy. Although the perception threshold of bitter taste remained unchanged, lingual mRNA levels of T2R5 were significantly increased in patients who complained of phantogeusia after chemotherapy. Chemotherapy specifically changed the gene expression of T1R3 and T2R5 in head and neck cancer patients with mild/moderate stomatitis, resulting in both dysgeusia of umami and sweet tastes as well as phantogeusia. 4. Laryngoscope, 126:E103-E109, 2016.","ja":"We aimed to test the hypothesis that chemotherapy changes the gene expression of taste receptors in the tongue to induce dysgeusia in patients with head and neck cancer. Prospective observation study. We enrolled 21 patients who received chemoradiotherapy and five patients who underwent radiotherapy for head and neck cancer. The messenger RNA (mRNA) levels of the taste receptor subunits T1R1, T1R2, T1R3, and T2R5 were measured in lingual mucosa scrapings obtained with a small spatula. The perception thresholds of umami, sweet, and bitter tastes were assessed by the whole mouth gustatory test. In four patients with severe stomatitis induced by chemoradiotherapy, the mRNA levels of T1R1, T1R2, T1R3, and T2R5 in the lingual mucosa were significantly decreased. However, in 17 patients with mild/moderate stomatitis, the mRNA levels of T1R3 were significantly and transiently decreased, whereas those of T1R1 and T1R2 remained unchanged and those of T2R5 mRNA were significantly and transiently increased after chemotherapy. There was a significant negative correlation between the perception thresholds of umami or sweet tastes and lingual mRNA levels of T1R3 in patients with mild/moderate stomatitis after chemotherapy. Although the perception threshold of bitter taste remained unchanged, lingual mRNA levels of T2R5 were significantly increased in patients who complained of phantogeusia after chemotherapy. Chemotherapy specifically changed the gene expression of T1R3 and T2R5 in head and neck cancer patients with mild/moderate stomatitis, resulting in both dysgeusia of umami and sweet tastes as well as phantogeusia. 4. Laryngoscope, 126:E103-E109, 2016."},"publication_date":"2015-09-30","publication_name":{"en":"The Laryngoscope","ja":"The Laryngoscope"},"volume":"Vol.126","number":"No.3","starting_page":"E103","ending_page":"E109","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1002/lary.25679"],"issn":["1531-4995"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/26391399","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=311105","label":"url"}],"paper_title":{"en":"Disruption of Heat Shock Protein 90 (Hsp90)-Protein Kinase Cδ (PKCδ) Interaction by (-)-Maackiain Suppresses Histamine H1 Receptor Gene Transcription in HeLa Cells","ja":"Disruption of Heat Shock Protein 90 (Hsp90)-Protein Kinase Cδ (PKCδ) Interaction by (-)-Maackiain Suppresses Histamine H1 Receptor Gene Transcription in HeLa Cells"},"authors":{"en":[{"name":"Nariai Yuki"},{"name":"Mizuguchi Hiroyuki"},{"name":"Ogasawara T"},{"name":"Nagai H"},{"name":"Sasaki Y"},{"name":"Okamoto Y"},{"name":"Yoshimura Yoshiyuki"},{"name":"Kitamura Yoshiaki"},{"name":"Nemoto Hisao"},{"name":"Takeda Noriaki"},{"name":"Fukui Hiroyuki"}],"ja":[{"name":"成相 祐希"},{"name":"水口 博之"},{"name":"Ogasawara T"},{"name":"Nagai H"},{"name":"Sasaki Y"},{"name":"Okamoto Y"},{"name":"吉村 好之"},{"name":"北村 嘉章"},{"name":"根本 尚夫"},{"name":"武田 憲昭"},{"name":"福井 裕行"}]},"description":{"en":"The histamine H1 receptor (H1R) gene is an allergic disease sensitive gene, and its expression level is strongly correlated with the severity of allergic symptoms. (-)-Maackiain was identified as a Kujin-derived anti-allergic compound that suppresses the up-regulation of the H1R gene. However, the underlying mechanism of H1R gene suppression remains unknown. Here, we sought to identify a target protein of (-)-maackiain and investigate its mechanism of action. A fluorescence quenching assay and immunoblot analysis identified heat shock protein 90 (Hsp90) as a target protein of (-)-maackiain. A pull-down assay revealed that (-)-maackiain disrupted the interaction of Hsp90 with PKCδ, resulting in the suppression of phorbol 12-myristate 13-acetate (PMA)-induced up-regulation of H1R gene expression in HeLa cells. Additional Hsp90 inhibitors, including 17-(allylamino)-17-demethoxygeldanamycin, celastrol, and novobiocin also suppressed PMA-induced H1R gene up-regulation. 17-(Allylamino)-17-demethoxygeldanamycin inhibited PKCδ translocation to the Golgi and phosphorylation of Tyr(311) on PKCδ. These data suggest that (-)-maackiain is a novel Hsp90 pathway inhibitor. The underlying mechanism of the suppression of PMA-induced up-regulation of H1R gene expression by (-)-maackiain and Hsp90 inhibitors is the inhibition of PKCδ activation through the disruption of Hsp90-PKCδ interaction. Involvement of Hsp90 in H1R gene up-regulation suggests that suppression of the Hsp90 pathway could be a novel therapeutic strategy for allergic rhinitis.","ja":"The histamine H1 receptor (H1R) gene is an allergic disease sensitive gene, and its expression level is strongly correlated with the severity of allergic symptoms. (-)-Maackiain was identified as a Kujin-derived anti-allergic compound that suppresses the up-regulation of the H1R gene. However, the underlying mechanism of H1R gene suppression remains unknown. Here, we sought to identify a target protein of (-)-maackiain and investigate its mechanism of action. A fluorescence quenching assay and immunoblot analysis identified heat shock protein 90 (Hsp90) as a target protein of (-)-maackiain. A pull-down assay revealed that (-)-maackiain disrupted the interaction of Hsp90 with PKCδ, resulting in the suppression of phorbol 12-myristate 13-acetate (PMA)-induced up-regulation of H1R gene expression in HeLa cells. Additional Hsp90 inhibitors, including 17-(allylamino)-17-demethoxygeldanamycin, celastrol, and novobiocin also suppressed PMA-induced H1R gene up-regulation. 17-(Allylamino)-17-demethoxygeldanamycin inhibited PKCδ translocation to the Golgi and phosphorylation of Tyr(311) on PKCδ. These data suggest that (-)-maackiain is a novel Hsp90 pathway inhibitor. The underlying mechanism of the suppression of PMA-induced up-regulation of H1R gene expression by (-)-maackiain and Hsp90 inhibitors is the inhibition of PKCδ activation through the disruption of Hsp90-PKCδ interaction. Involvement of Hsp90 in H1R gene up-regulation suggests that suppression of the Hsp90 pathway could be a novel therapeutic strategy for allergic rhinitis."},"publication_date":"2015-09-21","publication_name":{"en":"The Journal of Biological Chemistry","ja":"The Journal of Biological Chemistry"},"volume":"Vol.290","number":"No.45","starting_page":"27393","ending_page":"27402","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1074/jbc.M115.657023"],"issn":["1083-351X"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"https://repo.lib.tokushima-u.ac.jp/ja/115685","label":"url"},{"@id":"https://www.ncbi.nlm.nih.gov/pubmed/26516579","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=311101","label":"url"}],"paper_title":{"en":"Maackiain is a novel antiallergic compound that suppresses transcriptional upregulation of the histamine H1 receptor and interleukin-4 genes.","ja":"Maackiain is a novel antiallergic compound that suppresses transcriptional upregulation of the histamine H1 receptor and interleukin-4 genes."},"authors":{"en":[{"name":"Mizuguchi Hiroyuki"},{"name":"Nariai Y"},{"name":"Kato S"},{"name":"Nakano T"},{"name":"Kanayama T"},{"name":"Kashiwada Yoshiki"},{"name":"Nemoto Hisao"},{"name":"Kawazoe Kazuyoshi"},{"name":"Takaishi Yoshihisa"},{"name":"Kitamura Yoshiaki"},{"name":"Takeda Noriaki"},{"name":"Fukui Hiroyuki"}],"ja":[{"name":"水口 博之"},{"name":"Nariai Y"},{"name":"Kato S"},{"name":"Nakano T"},{"name":"Kanayama T"},{"name":"柏田 良樹"},{"name":"根本 尚夫"},{"name":"川添 和義"},{"name":"高石 喜久"},{"name":"北村 嘉章"},{"name":"武田 憲昭"},{"name":"福井 裕行"}]},"description":{"en":"Kujin contains antiallergic compounds that inhibit upregulation of histamine H1 receptor (H1R) and interleukin (IL)-4 gene expression. However, the underlying mechanism remains unknown. We sought to identify a Kujin-derived antiallergic compound and investigate its mechanism of action. The H1R and IL-4 mRNA levels were determined by real-time quantitative RT-PCR. To investigate the effects of maackiain in vivo, toluene-2,4-diisocyanate (TDI)-sensitized rats were used as a nasal hypersensitivity animal model. We identified (-)-maackiain as the responsible component. Synthetic maackiain showed stereoselectivity for the suppression of IL-4 gene expression but not for H1R gene expression, suggesting distinct target proteins for transcriptional signaling. (-)-Maackiain inhibited of PKCδ translocation to the Golgi and phosphorylation of Tyr(311) on PKCδ, which led to the suppression of H1R gene transcription. However, (-)-maackiain did not show any antioxidant activity or inhibition of PKCδ enzymatic activity per se. Pretreatment with maackiain alleviated nasal symptoms and suppressed TDI-induced upregulations of H1R and IL-4 gene expressions in TDI-sensitized rats. These data suggest that (-)-maackiain is a novel antiallergic compound that alleviates nasal symptoms in TDI-sensitized allergy model rats through the inhibition of H1R and IL-4 gene expression. The molecular mechanism underlying its suppressive effect for H1R gene expression is mediated by the inhibition of PKCδ activation.","ja":"Kujin contains antiallergic compounds that inhibit upregulation of histamine H1 receptor (H1R) and interleukin (IL)-4 gene expression. However, the underlying mechanism remains unknown. We sought to identify a Kujin-derived antiallergic compound and investigate its mechanism of action. The H1R and IL-4 mRNA levels were determined by real-time quantitative RT-PCR. To investigate the effects of maackiain in vivo, toluene-2,4-diisocyanate (TDI)-sensitized rats were used as a nasal hypersensitivity animal model. We identified (-)-maackiain as the responsible component. Synthetic maackiain showed stereoselectivity for the suppression of IL-4 gene expression but not for H1R gene expression, suggesting distinct target proteins for transcriptional signaling. (-)-Maackiain inhibited of PKCδ translocation to the Golgi and phosphorylation of Tyr(311) on PKCδ, which led to the suppression of H1R gene transcription. However, (-)-maackiain did not show any antioxidant activity or inhibition of PKCδ enzymatic activity per se. Pretreatment with maackiain alleviated nasal symptoms and suppressed TDI-induced upregulations of H1R and IL-4 gene expressions in TDI-sensitized rats. These data suggest that (-)-maackiain is a novel antiallergic compound that alleviates nasal symptoms in TDI-sensitized allergy model rats through the inhibition of H1R and IL-4 gene expression. The molecular mechanism underlying its suppressive effect for H1R gene expression is mediated by the inhibition of PKCδ activation."},"publication_date":"2015-08-10","publication_name":{"en":"Pharmacology Research & Perspectives","ja":"Pharmacology Research & Perspectives"},"volume":"Vol.3","number":"No.5","starting_page":"e00166","ending_page":"e00166","languages":["eng"],"referee":true,"identifiers":{"doi":["10.1002/prp2.166"],"issn":["2052-1707"]},"published_paper_type":"scientific_journal"}} {"insert":{"user_id":"B000344441","type":"published_papers"},"force":{"see_also":[{"@id":"http://ci.nii.ac.jp/naid/130005072175/","label":"url"},{"@id":"https://cir.nii.ac.jp/crid/1390282679247226880/","label":"url"},{"@id":"https://www.scopus.com/record/display.url?eid=2-s2.0-84930268027&origin=inward","label":"url"},{"@id":"https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=307373","label":"url"}],"paper_title":{"en":"A Case of Adenomatoid Odontogenic Tumor in the Maxillary Canine","ja":"上顎犬歯から発生した腺様歯原性腫瘍例"},"authors":{"en":[{"name":"内藤 圭介"},{"name":"島田 亜紀"},{"name":"Goda Masakazu"},{"name":"Endo Aki"},{"name":"Kitamura Yoshiaki"},{"name":"Abe Koji"},{"name":"Takeda Noriaki"}],"ja":[{"name":"内藤 圭介"},{"name":"島田 亜紀"},{"name":"合田 正和"},{"name":"遠藤 亜紀"},{"name":"北村 嘉章"},{"name":"阿部 晃治"},{"name":"武田 憲昭"}]},"description":{"en":"The adenomatoid odontogenic tumor (AOT) is a rare benign odontogenic tumor that is mostly found in jawbone. It is generally found in the incisor region of the maxilla of young females. It rarely extends into the paranasal sinuses. This article describes a case of AOT found in the maxilla and occupying the maxillary sinus and nasal cavity.