Portrait

教授 : 六反 一仁

氏名:六反  一仁 (ろくたん  かずひと)
Name:Kazuhito  Rokutan
肩書:教授
学位:博士
出身大学:京都府立医科大学 (1979年3月)
出身大学院(修士):KPUM
出身大学院(博士):( not registered )
性別:男性
E-mail:ŗōkūtāņ (@) bāśīċ ₍.₎ mėđ ₍.₎ tōkūśhīmā-ū ₍.₎ āċ ₍.₎ jp
WebPage:( not registered )
学歴:
( not registered )
職歴:
( not registered )
担当授業(2010年度入学生分):
基礎生物学 (2010徳島大学基礎科目群/共通教育)
基礎生物学 (2010徳島大学基礎科目群/共通教育)
ストレス制御医学 (2010医科学教育部 プロテオミクス医科学専攻/博士課程)
ストレス制御医学演習 (2010医科学教育部 プロテオミクス医科学専攻/博士課程)
ヒューマンサイエンス(形態と機能) (2010医科学教育部 医科学専攻/修士課程, 2010口腔科学教育部 口腔科学専攻/博士課程, 2010保健科学教育部 保健学専攻 看護学領域/博士前期課程, 2010保健科学教育部 保健学専攻 医用情報科学領域/博士前期課程, 2010保健科学教育部 保健学専攻 医用検査学領域/博士前期課程, 2010保健科学教育部 保健学専攻 看護学領域生涯健康支援学領域/博士後期課程, 2010保健科学教育部 保健学専攻 医用情報科学領域/博士後期課程, 2010保健科学教育部 保健学専攻 医用検査学領域/博士後期課程)
プロテオミクス医学応用入門実習 (2010医科学教育部 プロテオミクス医科学専攻/博士課程)
基礎医学(1) (2010医学部 医学科/学部課程)
生体制御医学実験実習 (2010医科学教育部 プロテオミクス医科学専攻/博士課程)
課題探求演習 (2010医科学教育部 医科学専攻/修士課程)
研究:
( not registered )
所属学会:
( not registered )
社会活動:
( not registered )
研究業績:
Book:
  1. Kyoichi Kishi, Arinobu Yamauchi, Fujiko Shizuka, Yasuhiro Kido, Takeshi Nikawa and Kazuhito Rokutan : Serotonin in the Central Nervous System and Periphery, --- Effect of macronutrient intakes on brain serotonin metabolite as measured by in vivo microdialysis in the rat ---, Elsevier, Tokyo, April 1995.
Academic Paper (Judged Full Paper):
  1. Shigetada Teshima, Kazuhito Rokutan, Masayuki Takahashi, Takeshi Nikawa, Yasuhiro Kido and Kyoichi Kishi : Alteration of the Respiratory Burst and Phagocytosis of Macrophages under Protein Malnutrition, Journal of Nutritional Science and Vitaminology, Vol.41, No.1, pp.127-137, 1995.
  2. Arinobu Yamauchi, Fujiko Shizuka, Takashi Yamamoto, Takeshi Nikawa, Yasuhiro Kido, Kazuhito Rokutan and Kyoichi Kishi : Amino acids and glucose differentially increased extracellular 5-hydroxyindoleacetic acid of the rat brain., Journal of Nutritional Science and Vitaminology, Vol.41, No.3, pp.325-340, 1995.
  3. Eiji Takeda, Kazumi Takata, Hisami Yamanaka, Yutaka Taketani, Kyoko Morita, Ken-ichi Miyamoto, Masayuki Shono, Shigetada Teshima and Kazuhito Rokutan : Vitamin D3 elicits calcium response and activates blood monocyte-derived macrophages from patients with vitamin D dependent rickets type 2, FEBS Letters, Vol.396, pp.157-160, 1996.
  4. Shigetada Teshima, Kazuhito Rokutan, Masayuki Takahashi, Takeshi Nikawa and Kyoichi Kishi : Induction of heat shock proteins and their possible roles in macrophages during activation by macrophage colony-stimulating factor, Biochemical Journal, Vol.315, pp.497-504, 1996.
  5. Eiji Takeda, Kazumi Takata, Hisami Yamanaka, Yutaka Taketani, Kyoko Morita, Ken-ichi Miyamoto, Masayuki Shono, Shigetada Teshima and Kazuhito Rokutan : Vitamin D3 elicits calcium response and activates blood monocyte-derived macrophages from patients with vitamin D dependent rickets type 2, FEBS Letters, Vol.396, pp.157-160, 1996.
  6. Kazuhito Rokutan, Tetsuya Hirakawa, Shigetada Teshima, Soichi Honda and Kyoichi Kishi : Glutathione Depletion Impairs Transcriptional Activation of Heat Shock Genes in Primary Cultures of Guinea Pig Gastric Mucosal Cells, Journal of Clinical Investigation, Vol.97, No.10, pp.2242-2250, 1996.
  7. Tetsuya Hirakawa, Kazuhito Rokutan, Takeshi Nikawa and Kyoichi Kishi : Geranylgeranylacetone induces heat shock proteins. in cultured guinea pig gastric mucosal cells and rat gastric mucosa, Gastroenterology, Vol.111, No.2, pp.345-357, 1996.
  8. Yasuhiro Kido, Takayoshi Tsukahara, Kazuhito Rokutan, Fujiko Shizuka and Kyoichi Kishi : Japanese allowance is sufficient for moderate physical exercise in young men., Journal of Nutritional Science and Vitaminology, Vol.43, No.1, pp.59-71, 1997.
  9. Kazuhito Rokutan, Shigetada Teshima, Mami Miyoshi, Takeshi Nikawa and Kyoichi Kishi : Oxidant-lnduced Activation of Nuclear Factor-Kappa B in Cultured Guinea Pig Gastric Epithelial Cells, Digestive Diseases and Sciences, Vol.42, No.9, pp.1880-1889, 1997.
  10. Takeshi Nikawa, Kazuhito Rokutan, Kayo Nanba, Kaori Tokuoka, Shigetada Teshima, Michael J Engle, David H Alpers and Kyoichi Kishi : Vitamin A Up-Regulates Expression of Bone-Type Alkaline Phosphatase in a Rat Small Intestinal Crypt Cell Line and Fetal Rat Small Intestine, Biochemical and Molecular Roles of Nutrients, Vol.128, pp.1869-1877, 1998.
  11. Kazuhito Rokutan, Shigetada Teshima, Mami Miyoshi, Tomoko Kawai, Takeshi Nikawa and Kyoichi Kishi : Glutathione depletion inhibits oxidant-induced activation of nuclear factor-kappa B,AP-1,and c-Jun/ATF-2 in cultured guinea-pig gastric epithelial cells, Journal of Gastroenterology, Vol.33, pp.646-655, 1998.
  12. Shigetada Teshima, Kazuhito Rokutan, Takeshi Nikawa and Kyoichi Kishi : Guinea pig gastric mucosal cells produce abundant superoxide anion through an NADPH oxidase-like system, Gastroenterology., Vol.115, No.5, pp.1186-1196, 1998.
  13. Shigetada Teshima, Kazuhito Rokutan, Takeshi Nikawa and Kyoichi Kishi : Macrophage Colony-Stimulating Factor Stimulates Synthesis and Secretion of a Mouse Homolog of a Human IgE-Dependent Histamine-Releasing Factor by Macrophages In Vitro and In Vivo, The Journal of Immunology, Vol.161, No.11, pp.6356-6366, 1998.
  14. Takeshi Nikawa, Kenji Odahara, Hiroyuki Koizumi, Yasuhiro Kido, Shigetada Teshima, Kazuhito Rokutan and Kyoichi Kishi : Vitamin A Prevents the Decline in Immunoglobulin A and Th2 Cytokine Levels in Small Intestinal Mucosa of Protein-Malnourished Mice1, Biochemical and Molecular Action of Nutrients, Vol.129, pp.934-941, 1999.
  15. Shigetada Teshima, Shohko Tsunawaki and Kazuhito Rokutan : Helicobacter pylori lipopolysaccharide enhances the expression of NADPH oxidase components in cultured guinea pig gastric mucosal cells, FEBS Letters, Vol.452, pp.243-246, 1999.
  16. Kazuhito Rokutan, Shigetada Teshima, Tomoko Kawai, Tsukasa Kawahara, Kenji Kusumoto, Tohru Mizushima and Kyoichi Kishi : Geranylgeranylacetone stimulates mucin synthesis in cultured guinea pig gastric pit cells by inducing a neuronal nitric oxide synthase, Journal of Gastroenterology, Vol.35, pp.673-681, 2000.
  17. Tomoko Kawai, Shigetada Teshima, Kenji Kusumoto, Tsukasa Kawahara, Kazumi Kondo, Kyoichi Kishi and Kazuhito Rokutan : A non-toxic heat shock protein 70 inducer, geranyl-geranyl-acetone,restores the heat shock response in gastric mucosa of protein-malnourished rats, The Journal of Laboratory and Clinical Medicine, Vol.136, No.2, pp.138-148, 2000.
  18. Kazuhito Rokutan, Mami Miyoshi, Shigetada Teshima, Tomoko Kawai, Tsukasa Kuwahara and Kyoichi Kishi : Phenylarsine oxide inhibits heat shock protein 70 induction in cultured guinea pig gastric mucosal cells, American Journal of Physiology, Cell Physiology, Vol.279, No.5, pp.C1506-C1515, 2000.
  19. Shigetada Teshima, Hiromu Kutsumi, Tsukasa Kawahara, Kyoichi Kishi and Kazuhito Rokutan : Regulation of growth and apoptosis of cultured guinea pig gastric mucosal cells by mitogenic oxidase 1, American Joural of Physiology - Gastrointestinal and Liver Physiology, Vol.279, No.6, pp.G1169-G1176, 2000.
  20. Takeshi Nikawa, Madoka Ikemoto, Kaori Tokuoka, Shigetada Teshima, Alpers H. David, Yoshihiro Masui, Kyoichi Kishi and Kazuhito Rokutan : Interleukin-1β enhances retinoic acid-mediated expression of bone-type alkaline phosphatase in rat IEC-6 cells, American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol.280, No.3, pp.510-517, 2001.
  21. Madoka Ikemoto, Takeshi Nikawa, Shinichi Takeda, Chiho Watanabe, Takako Kitano, Baldwin M. Kenneth, Ryutaro Izumi, Ikuya Nonaka, Takae Towatari, Shigetada Teshima, Kazuhito Rokutan and Kyoichi Kishi : Space Shuttle flight (STS-90) enhances dagradation of rat myosin heavy chain in association with activation of ubiquitin-proteasome pathway, The FASEB Journal, Vol.15, No.7, pp.1279-1281, 2001.
  22. Shizuo Ikeyama, Kenji Kusumoto, Hidenori Miyake, Kazuhito Rokutan and Seiki Tashiro : A non-toxic heat shock protein 70 inducer, geranylgeranylacetone,suppresses apoptosis of cultured rat hepatocytes caused by hydrogen peroxide and ethanol, Journal of Hepatology, Vol.35, No.1, pp.53-61, 2001.
  23. Tsukasa Kawahara, Shigetada Teshima, Ayuko Oka, Toshiro Sugiyama, Kyoichi Kishi and Kazuhito Rokutan : Type 1 Helicobacter pylori Lipopolysaccharide Stimulates Toll-Like Receptor 4 and Activates Mitogen Oxidase 1 in Gastric PIt Cells, Infection and Immunity, Vol.69, No.7, pp.4382-4389, 2001.
  24. Takeshi Nikawa, Madoka Ikemoto, Mihoko Kano, Kaori Tokuoka, Katsuya Hirasaka, Shoji Uehara, Kiyoshi Takatsu, Kazuhito Rokutan and Kyoichi Kishi : Impaired Vitamin A-Mediated Mucosal IgA Response in IL-5 Receptor-Knockout Mice, Biochemical and Biophysical Research Communications, Vol.285, No.2, pp.546-549, 2001.
  25. Tsukasa Kawahara, Yuki Kuwano, Shigetada Kondo, Toshiro Sugiyama, Tomoko Kawai, Takeshi Nikawa, Kyoichi Kishi and Kazuhito Rokutan : Helicobacter pylori lipopolysaccharide from type 1, but not type 2 strains, stimulates apoptosis of cultured gastric mucosal cells, The Journal of Medical Investigation, Vol.48, No.3,4, pp.167-174, 2001.
  26. Tsukasa Kawahara, Yuki Kuwano, Shigetada Kondo, Tomoko Kawai, Takeshi Nikawa, Kyoichi Kishi and Kazuhito Rokutan : Toll-like receptor 4 regulates gastric pit cell responses to Helicobacter pylori infection, The Journal of Medical Investigation, Vol.48, No.3,4, pp.190-197, 2001.
  27. Tsukasa Kawahara, Shigetada Teshima, Yuki Kuwano, Ayuko Oka, Kyoichi Kishi and Kazuhito Rokutan : Helicobacter pylori lipopolysaccharide induces apoptosis of cultured guinea pig gastric mucosal cells, American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol.281, No.3, pp.726-734, 2001.
  28. Wataru Tomisato, Shinji Tsutsumi, Kazuhito Rokutan, Tomofusa Tsuchiya and Tohru Mizushima : NSAIDs induce both necrosis and apoptosis in guinea pig gastric mucosal cells in primary culture, American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol.281, No.4, pp.1092-1100, 2001.
  29. Kosuke Oikawa, Tetsuya Ohbayashi, Junsei Mimura, Yoshiaki Fujii-Kuriyama, Shigetada Teshima, Kazuhito Rokutan, Kiyoshi Mukai and Masahiko Kuroda : Dioxin Stimulates Synthesis and Secretion of IgE-Dependent Histamine-Releasing Factor, Biochemical and Biophysical Research Communications, Vol.290, No.3, pp.984-987, 2002.
  30. Shinji Tsutsumi, Wataru Tomisato, Tatsunori Takano, Kazuhito Rokutan, Tomofusa Tsuchiya and Tohru Mizushima : Gastric irritant-induced apoptosis in guinea pig gastric mucosal cells in primary culture, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol.1589, No.2, pp.168-180, 2002.
  31. Hironobu Oda, Hidenori Miyake, Takashi Iwata, Kenji Kusumoto, Kazuhito Rokutan and Seiki Tashiro : Geranylgeranylacetone Suppresses Inflammatory Responses and Improves Survival After Massive Hepatectomy in Rats, Journal of Gastrointestinal Surgery, Vol.6, No.3, pp.464-472, 2002.
  32. Takeshi Nikawa, Madoka Ikemoto, Takashi Sakai, Mihoko Kano, Takako Kitano, Tsukasa Kawahara, Shigetada Teshima, Kazuhito Rokutan and Kyoichi Kishi : Effects of a Soy Protein Diet on Exercise-Induced Muscle Protein Catabolism in Rats, Nutrition, Vol.18, No.6, pp.490-495, 2002.
  33. Takeshi Nikawa, Madoka Ikemoto, Takashi Sakai, Mihoko Kano, Takako Kitano, Tsukasa Kawahara, Shigetada Teshima, Kazuhito Rokutan and Kyoichi Kishi : Effects of a soy protein diet on exercise-induced muscle protein catabolism in rats, Journal of Nutrition, Vol.18, No.6, pp.490-495, 2002.
  34. L.S. Yoshida, S. Nishida, T. Shimoyama, T. Kawahara, Kazuhito Rokutan and S. Tsunawaki : Expression of a p67phox homolog in Caco-2 cells giving O2-reconstituting ability to cytochrome b558 together with recombinant p47phox, Biochemical and Biophysical Research Communications, Vol.296, No.5, pp.1322-1328, 2002.
  35. Chamulitrat Walee, Schmidt Rainer, Tomakidi Pascal, Stremmel Wolfgang, Chunglok Warangkana, Tsukasa Kawahara and Kazuhito Rokutan : Association of gp91phox homolog Nox1 with anchorage-independent growth and MAP kinase-activation of transformed human keratinocytes, Oncogene, Vol.22, No.38, pp.6045-6053, 2003.
  36. Hidenori Miyake, Masahiko Fujii, Katsuya Sasaki, Tsutomu Ando, Shizuo Ikeyama, Takashi Iwata, Kazuhito Rokutan and Seiki Tashiro : Heat Shock Protein 70 Induction in Hepatocytes after Right Portal Vein Embolization, Hepato-Gastroenterology, Vol.50, No.54, pp.2084-2087, 2003.
  37. LS Yoshida, S Nishida, T Shimoyama, T Kawahara, S Kondo-Teshima, Kazuhito Rokutan, T Kobayashi and S Tsunawaki : Superoxide generation by Nox1 in guinea pig gastric mucosal cells involves a component with p67(phox)-ability., Biological and Pharmaceutical Bulletin, Vol.27, pp.147-155, 2004.
  38. Kazuo Yoneda, Kazuhito Rokutan, Yoichi Nakamura, Hiroaki Yanagawa, Shigetada Kondo and Saburo Sone : Stimulation of human bronchial epithelial cells by IgE-dependent histamine-releasing factor, The American Journal of Physiology - Lung Cellular and Molecular Physiology, Vol.286, No.1, pp.174-181, 2004.
  39. Satiko Lucia Yoshida, Satoshi Nishida, Takashi Shimoyama, Tsukasa Kawahara, Shigetada Kondo, Kazuhito Rokutan, Toshihiro Kobayashi and Shohko Tsunawaki : Superoxide Generation by Nox1 in Guinea Pig Gastric Mucosal Cells Involves a Component with p67phox-Ability, Biological and Pharmaceutical Bulletin, Vol.27, No.2, pp.147-155, 2004.
  40. Tsukasa Kawahara, Yuki Kuwano, Shigetada Kondo, Ryu Takeya, Hideki Sumimoto, Kyoichi Kishi, Shohko Tsunawaki, Toshiya Hirayama and Kazuhito Rokutan : Role of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 1 in Oxidative Burst Response to Toll-Like Receptor 5 Signaling in Large Intestinal Epithelial Cells, The Journal of Immunology, Vol.172, No.5, pp.3051-3058, 2004.
  41. Chamulitrat Walee, Stermmel Wolfgang, Tsukasa Kawahara, Kazuhito Rokutan, Hirotada Fujii, Wingler Kirstin, Schmidt H.H.W. Harald and Schmidt Rainer : A Constitutive NADPH Oxidase-Like System Containing gp91 phox Homologs in Human Keratinocytes, The Journal of Investigative Dermatology, Vol.122, No.4, pp.1000-1009, 2004.
  42. Eiji Takeda, Junji Terao, Nakaya Yukaka, Ken-ichi Miyamoto, Yoshinobu Baba, Hiroshi Chuman, Ryuji Kaji, Tetsuro Ohmori and Kazuhito Rokutan : Stress control and human nutrition, The Journal of Medical Investigation, Vol.51, No.3, p.4, 2004.
  43. Shigetada Kondo, Kazumi Kondo, Prado-Lourenco Leonel, Gonzalez-Herrera Gabriela Irma, Kazuhito Rokutan, bayard Francis, Arnal Jean-Francois and Prats Anne-Catherine : Hyperglycemia upregulates translation of the fibroblast growth factor 2 mRNA in mouse aorta via internal ribosome entry site, The FASEB Journal, Vol.18, No.13, pp.1583-1585, 2004.
  44. Kazunori Sekine, Kazuhito Rokutan and Noriaki Takeda : Microarray Analysis of Stress-Related Gene Expression in Patients with Ménière's Disease, ORL; Journal for Oto-Rhino-Laryngology and Its Related Specialties, Vol.67, No.5, pp.294-299, 2005.
  45. Yutaka Nakaya, Y Hata, K Ishida, Akira Takahashi, Kyoko Morita and Kazuhito Rokutan : Approach to novel functional foods for stress control 2. Microarray assessment of exercise in healthy volunteers., The Journal of Medical Investigation, Vol.52, No.Suppl, pp.242-243, 2005.
  46. Junichi Iga, Shu-ichi Ueno, K Yamauchi, I Motoki, S Tayoshi, K Ohta, H Song, Kyoko Morita, Kazuhito Rokutan and Tetsuro Ohmori : Serotonin transporter mRNA expression in peripheral leukocytes of patients with major depression before and after treatment with paroxetine., Neuroscience Letters, Vol.389, No.1, pp.12-16, 2005.
  47. M Fukuyama, Kazuhito Rokutan, T Sano, H Miyake, M Shimada and S Tashiro : Overexpression of a novel superoxide-producing enzyme, NADPH oxidase 1, in adenoma and well differentiated adenocarcinoma of the human colon., Cancer Letters, Vol.221, No.1, pp.97-104, 2005.
  48. Tsukasa Kawahara, Motoyuki Kohjima, Yuki Kuwano, Hisano Mino, Shigetada Kondo, Ryu Takeya, Shohko Tsunawaki, Akihiro Wada, Hideki Sumimoto and Kazuhito Rokutan : Helicobacter pylori lipopolysaccharide activates Rac1 and transcription of NADPH oxidase Nox1 and its organizer NOXO1 in guines pig gastric mucosal cells, American Journal of Physiology, Cell Physiology, Vol.288, No.2, pp.450-457, 2005.
  49. Kenji Kusumoto, Tsukasa Kawahara, Yuki Kuwano, Shigetada Kondo, Kyoko Morita, Kyoichi Kishi and Kazuhito Rokutan : Ecabet sodium inhibits Helicobacter pylori lipopolysaccharide-induced activation of NADPH oxidase 1 or apoptosis of guinea pig gastric mucosal cells, American Journal of Physiology - Gastrointestinal and Liver Physiology, Vol.288, No.2, pp.G300-G307, 2005.
  50. Mitsutoshi Fukuyama, Kazuhito Rokutan, Toshiaki Sano, Hidenori Miyake, Mitsuo Shimada and Seiki Tashiro : Overexpression of a novel superoxide-producing enzyme,NADPH oxidase 1,in adenoma and well differentiated adenocarcinoma of the human colon, Cancer Letters, Vol.221, No.1, pp.97-104, 2005.
  51. Tetsuro Ago, Takanari Kitazono, Junya Kuroda, Yasuhiro Kumai, Masahiro Kamouchi, Hiroaki Ooboshi, Masanori Wakisaka, Tsukasa Kawahara, Kazuhito Rokutan, Setsuro Ibayashi and Mitsuo Iida : NAD(P)H Oxidases in Rat Basilar Arterial Endothelial Cells, Stroke, Vol.36, No.5, pp.1040-1046, 2005.
  52. Atsuo Sekiyama, Haruyasu Ueda, Shin-ichiro Kashiwamura, Ryuji Sekiyama, Masatoshi Takeda, Kazuhito Rokutan and Haruki Okamura : A Stress-Induced, Superoxide-Mediated Caspase-1 Activation Pathway Causes Plasma IL-18 Upregulation, Immunity, Vol.22, No.6, pp.669-677, 2005.
  53. Kyoko Morita, Toshiro Saito, Masayuki Ohta, Testsuro Ohmori, Kaori Kawai, Shigetada Teshima-Kondo and Kazuhito Rokutan : Expression of analysis of psychological stress-associated genes in peripheral blood leukocytes, Neuroscience Letters, Vol.381, No.1-2, pp.57-62, 2005.
  54. Kyoko Morita, Toshiro Saito, Masayuki Ohta, Tetsuro Ohmori, Kaori Kawai, Shigetada Kondo and Kazuhito Rokutan : Expression analysis of psychological stress-associated genes in peripheral blood leukocytes, Neuroscience Letters, Vol.381, No.1-2, pp.57-62, 2005.
  55. 武田 憲昭, 関根 和教, 佐藤 豪, 六反 一仁 : メニエール病患者におけるストレス関連遺伝子発現変化のDNAマイクロアレイ解析, 厚生労働省科学研究補助金，特定疾患対策研究事業，前庭機能異常に関する調査研究，平成17年度報告書, 148-152頁, 2006年.
  56. Kazuhito Rokutan, T Kawahara, Y Kuwano, K Tominaga, A Seiyama and S Teshima-Kondo : NADPH Oxidase in the gastrointestinal tract: A potential role of Nox1 in innate immune response and carcinogenesis., Antioxid. Redox Signaling, Vol.8, No.9,10, pp.1573-1582, 2006.
  57. F Teramoto, Kazuhito Rokutan, Y Sugano, K Oku, E Kishino, K Fujita, K Hara, K Kishi, M Fukunaga and T Morita : Long-term administration of 4G-beta-D-galactosylsucrose (lactosucrose) enhances intestinal calcium absorption in young women: a randomized, placebo-controlled 96-wk study., Journal of Nutritional Science and Vitaminology, Vol.52, No.5, pp.337-346, 2006.
  58. R Shimooka, Y Kido, N Chiba, J Tanaka, Kazuhito Rokutan, H Furocji, K Hirasaka, T Nikawa and K Kishi : Soy protein diet prevents hypermethioninemia caused by portacaval shunt in rats., The Journal of Medical Investigation, Vol.53, No.3-4, pp.255-263, 2006.
  59. T Wada, Hiroyoshi Sei, K Kusumoto, K Kitaoka, S Chikahisa, Kazuhito Rokutan and Y Morita : Geranylgeranylacetone, an inducer of HSP 70, attenuates REM sleep rebound after sleep deprivation., Brain Research Bulletin, Vol.69, No.4, pp.388-392, 2006.
  60. Atsuo Sekiyama, Haruyasu Ueda, Shin-ichiro Kashiwamura, Kensei Nishida, Seiko Yamaguchi, Hideyuki Sasaki, Yuki Kuwano, Kaori Kawai, Shigetada Kondo, Kazuhito Rokutan and Haruki Okamura : A role of the adrenal gland in stress-induced up-regulation of cytokines in plasma, Journal of Neuroimmunology, Vol.171, No.1-2, pp.38-44, 2006.
  61. Yuki Kuwano, Tsukasa Kawahara, Hironori Yamamoto, Shigetada Kondo, Kumiko Tominaga, Kiyoshi Masuda, Kyoichi Kishi, Kyoko Morita and Kazuhito Rokutan : Interferon-γ activates transcription of NADPH oxidase 1 gene and upregulates production of superoxide anion by human large intestinal epithelial cells, American Journal of Physiology, Cell Physiology, Vol.290, No.2, pp.C433-C443, 2006.
  62. Junichi Iga, Shu-ichi Ueno, Ken Yamauchi, Shusuke Numata, Ikuyo Motoki, Sumiko Tayoshi, Sawako Kinouchi, Koshi Ohta, Hongwei Song, Kyoko Morita, Kazuhito Rokutan, Hirotaka Tanaba, Akira Sano and Tetsuro Ohmori : Gene expression and association analysis of LIM (PDLIM5) in major depression., Neuroscience Letters, Vol.400, No.3, pp.203-207, 2006.
  63. Tomoko Kawai, Kyoko Morita, Kiyoshi Masuda, Kensei Nishida, Michiyo Shikishima, M Ohta, T Saito and Kazuhito Rokutan : Gene expression signature in peripheral blood cells from medical students exposed to chronic psychological stress., Biol Psychol., Vol.2007 doi:10.1016/j.biopsycho, 2007.
  64. Junichi Iga, Shu-ichi Ueno, K Yamauchi, S Numata, I Motoki, S Tayoshi, S Kinouchi, K Ohta, H Song, Kyoko Morita, Kazuhito Rokutan, H Tanaba and Tetsuro Ohmori : Gene expression and association analysis of LIM (PDLIM5) in major depression., Neuroscience Letters, Vol.400, No.3, pp.203-207, 2007.
  65. Sachiko Chikahisa, Tominaga Kumiko, Tomoko Kawai, Kazuyoshi Kitaoka, Oishi Katsutaka, Ishida Norio, Kazuhito Rokutan and Hiroyoshi Sei : Bezafibrate, a PPARs agonist, decreases body temperature and enhances EEG delta oscillation during sleep in mice., Endocrinology, Vol.140, No.10, pp.5262-5271, 2008.
  66. Satoru Dakeshita, Tomoko Kawai, Hirokazu Uemura, Mineyoshi Hiyoshi, Etsuko Oguma, Hyogo Horiguchi, Fujio Kayama, Keiko Aoshima, Satoshi Shirahama, Kazuhito Rokutan and Kokichi Arisawa : Gene expression signatures in peripheral blood cells from Japanese women exposed to environmental cadmium, Toxicology, Vol.257, No.1,2, pp.25-32, 2009.
  67. Tomoko Kawai, Kyoko Morita, Kiyoshi Masuda, Kensei Nishida, Michiyo Shikishima, M Ohta, T Saito and Kazuhito Rokutan : Gene expression signature in peripheral blood cells from medical students exposed to chronic psychological stress., Biol Psychol, Vol.in press, .
  68. Tomoko Kawai, Kyoko Morita, Kiyoshi Masuda, Kensei Nishida, Atsuo Sekiyama, S Teshima-Kondo, M Ohta, T Saito and Kazuhito Rokutan : Physical exercise-associated gene expression signatures in peripheral blood., Clin J Sport Med., Vol.in press, .
  69. Sawako Kinouchi, Junichi Iga, Ueno Shi-Ichi, Ymauchi Ken, Shusuke Numata, Song Hongwei, Satsuki Sumitani, Shibuya-Tayoshi Sumiko, Mari Haku, Toshiyuki Yasui, Minoru Irahara, Morita Kyoki, Kazuhito Rokutan and Tetsuro Ohmori : FKBP5,SERT and COMY mRNA expressions in the peripheral leukocytes during menstruction cycle in healthy reproductive females, Neuroscience Letters, Vol.434, pp.124-128, .
Review, Commentary:
  1. 二川 健, 六反 一仁 : 消化管粘膜細胞と細胞増殖因子:小腸上皮細胞と増殖因子, G.I.Research, Vol.3, No.2, 50-56頁, 1995年2月.
  2. 二川 健, 六反 一仁 : 消化器疾患ー分子生物学的アプローチ発生・生理への分子生物学的アプローチー小腸上皮細胞の分化と分子生物学:レチノイン酸とTGF-βによる分子誘導機序を中心として, 医学のあゆみ, Vol.176, No.13, 833-836頁, 1996年3月.
  3. Kazuhito Rokutan, Tetsuya Hirakawa, Shigetada Teshima, Yoko Nakano, Mami Miyoshi, Tomoko Kawai, Emi Konda, Hiroko Morinaga, Takeshi Nikawa and Kyoichi Kishi : Implications of heat shock/stress proteins for medicine and disease, The Journal of Medical Investigation, Vol.44, pp.137-147, 1998.
  4. 岸 恭一, 六反 一仁, 二川 健 : ストレスと栄養:ストレスと蛋白質栄養, ストレス科学, Vol.13, No.3, 86-93頁, 1998年12月.
  5. 二川 健, 手嶋 茂忠, 六反 一仁, 岸 恭一 : 代謝・免疫器官としての腸管:腸管局所免疫に対するビタミンAの効果, 小児外科, Vol.32, No.2, 167-173頁, 2000年2月.
  6. 岸 恭一, 二川 健, 六反 一仁 : アミノ酸生理作用:とくにシステイン, 臨床栄養, Vol.100, No.2, 150-154頁, 2002年2月.
  7. 六反 一仁 : 分子シャペロン誘導剤を用いた消化器疾患の治療戦略, 日本薬理学雑誌, Vol.121, No.1, 15-20頁, 2003年1月.
  8. 岸 恭一, 六反 一仁, 二川 健, 近藤 茂忠 : 生体におけるアミノ酸代謝, 肝胆膵, Vol.47, No.1, 9-16頁, 2003年7月.
  9. 六反 一仁 : 外部からの刺激に対する細胞の環境適応応答のしくみ, --- 熱ショック応答を中心に ---, G.I.Research, Vol.12, No.4, 60-65頁, 2004年8月.
  10. Eiji Takeda, Junji Terao, Yutaka Nakaya, Ken-ichi Miyamoto, Yoshinobu Baba, Hiroshi Chuman, Ryuji Kaji, Tetsuro Ohmori and Kazuhito Rokutan : Stress control and human nutrition, The Journal of Medical Investigation, Vol.51, No.3,4, pp.139-145, Aug. 2004.
  11. 楠本 健二, 増田 清志, 近藤 茂忠, 森田 恭子, 六反 一仁 : HSPは消化管防御機構にどのように関与するのか?, 分子消化器病, Vol.1, No.3, 209-213頁, 2004年9月.
  12. 森田 恭子, 関山 敦生, 六反 一仁 : ストレスと神経·内分泌ネットワーク, 脳と神経, Vol.57, No.5, 397-406頁, 2005年5月.
  13. Kazuhito Rokutan, Kyoko Morita, Kiyoshi Masuda, Kumiko Tominaga, Michiyo Shikishima, Shigetada Kondo, Tetsuro Omori and Atsuo Sekiyama : Gene expression profiling in peripheral blood leukocytes as a new approach for assessment of human stress response, The Journal of Medical Investigation, Vol.52, No.3,4, pp.137-144, Aug. 2005.
Proceeding of International Conference:
  1. Takeshi Nikawa, Atsuko Sakai, M Emgle, David H. Alpers, Kazuhito Rokutan and Kyoichi Kishi : Stimulatory action of retinoic acid on differentiation of rat small intestinal cells, Annual Meeting of the American Gastroenterological Association, San Diego, May 1995.
  2. Takeshi Nikawa, Shigetada Teshima, David H. Alpers, Kyoichi Kishi and Kazuhito Rokutan : Involvement of inflammatory cytokines in retinoic acid-mediated maturation of small intestinal epithelial cells, Annual Meeting of the American Gastroenterological Association, San Francisco, May 1996.
  3. Takeshi Nikawa, Kazuhito Rokutan, Shigetada Teshima, David H. Alpers and Kyoichi Kishi : Inflammatory cytokines are involved in retinoic acid-mediated maturation of small intestinal epithelial cells, 12th Federation of Asian and Oseanian Biochemists and Molecular Biologists, Tokushima, Oct. 1996.
  4. Takeshi Nikawa, K Tokuoka, Shigetada Teshima, Madoka Ikemoto, Takae Towatari, David H. Alpers, Kazuhito Rokutan and Kyoichi Kishi : Synergistic effects of retinoic acid and IL-1 on expression of the bone-type alkaline phosphatase and retinoid receptors in small intestinal epithelial IEC-6 cells, Annual Meeting of the American Association of the American Gastroenterological Association, Orlando, May 1999.
  5. Takeshi Nikawa, Madoka Ikemoto, Chiho Watanabe, Takako Kitano, Shigetada Teshima, Kazuhito Rokutan, Kyoichi Kishi, Shinichi Takeda, Ikuya Nonaka, Kenneth M. Baldwin and Ryutaro Izumi : Tail-suspension stimulates expression of muscle proteases and cysteine supplementation prevents loss of muscle weight in tail-suspended rats, 21th Annual Gravitational Physiology Meeting, Nagoya, April 2000.
  6. Takeshi Nikawa, Madoka Ikemoto, Takako Kitano, Mihoko Kano, Shigetada Teshima, Kazuhito Rokutan, Kyoichi Kishi, Shinichi Takeda, Ikuya Nonaka, Kenneth M. Baldwin, Ryutaro Izumi and Takae Towatari : Speaceflight and unweighting enhance degradation of rat myosin heavy chain in association with activation of ubiquitin-proteasome pathway and antiozidative nutrient prevents muscle protein degradation in tail-suspended rats, 17th International Congress of Nutrition, Wien, Aug. 2001.
  7. Takeshi Nikawa, Madoka Ikemoto, Takako Kitano, Mihoko Kano, Shigetada Teshima, Kazuhito Rokutan, Kyoichi Kishi, Shinichi Takeda, Ikuya Nonaka, Kenneth M. Baldwin, Ryutaro Izumi and Takae Towatari : Space Shuttle flight enhances degradation of rat myosin heavy chain in association with activation of ubiquitin-proteasome pathway, 2nd iInternational Society of Proteolysis, Munich, Geramany, Oct. 2001.
  8. Kazuhito Rokutan : Roles of Nox1 in innate immune response and cancer development in the gastrointestinal tract, 1st Internatinal Conference on NAD(P)H oxidase, Frankfurt, May 2002.
  9. Kazuhito Rokutan : Pathophysiology of Nox1 in the gastrointestinal tract, Second Internatinal Conference on NAD(P)H oxidase, Atlanta, March 2004.
  10. Kazuhito Rokutan : Role of heat shock proteins in mastric mucosal protection, Shandon Digestive Disease Week(DDW)Plenary Lecture, Shandon, Aug. 2004.
  11. Kazunori Sekine, Kyoko Morita, Masuda Kiyoshi, Gou Satou, Kazuhito Rokutan and Noriaki Takeda : Microarray analysis of stress-related gene expression in patients with Ménière's disease, 24TH Barany Society Meeting, Uppsala, Sweden, June 2006.
Proceeding of Domestic Conference:
  1. 六反 一仁 : スーパーオキシドと細胞情報伝達, 第26回日本過酸化脂質·フリーラジカル学会大会, 2002年.
  2. 六反 一仁 : 消化管とストレス応答, --- ー環境適応反応を誘導する新規ストレス関連遺伝子ー ---, 第34回日本消化吸収学会総会, 2003年.
  3. 六反 一仁 : ストレスのゲノミクス·バイオインフォマテイクス技術の開発とその臨床応用, 第20回日本ストレス学会学術総会, 2004年.
  4. 関根 和教, 六反 一仁, 武田 憲昭 : ストレス解析用DNAチップを用いたメニエール病患者のストレス評価, 第106回日本耳鼻咽喉科学会, 2005年5月.
  5. 関根 和教, 佐藤 豪, 六反 一仁, 武田 憲昭 : メニエール病患者におけるストレス関連遺伝子発現変化のDNAマイクロアレイ解析, 第64回日本めまい平衡医学会, 2005年11月.
Et cetra, Workshop:
  1. 岸 恭一, 六反 一仁, 二川 健 : 運動による筋傷害の成因とその予防に対する栄養学的アプローチ, 文部省科学研究費一般研究C, 1988年.
  2. 二川 健, 六反 一仁 : サイトカインを介した小腸特異酵素の発現とその分子機構, 文部省科学研究費 一般研究C, 1996年.
  3. 岸 恭一, 六反 一仁, 木戸 康博, 二川 健 : 脳微小透析法による非特異的栄養素摂取調節構の解明, 文部省科学研究費 一般研究C, 1996年.
  4. 岸 恭一, 六反 一仁, 木戸 康博, 二川 健 : 微小重力環境下の筋萎縮の予防に対する栄養学的アプローチ, 日本宇宙環境利用推進センターフロンティア共同研究, 1996年.
  5. 二川 健, 岸 恭一, 六反 一仁, 埜中 征哉 : 蛋白質分解酵素阻害剤による無重力下の筋萎縮および骨粗鬆症の治療, 日本宇宙フォーラム公募地上研究, 1997年.
  6. 岸 恭一, 二川 健, 六反 一仁, 埜中 征哉 : 無重力による筋萎縮に有効な宇宙食の開発, 日本宇宙フォーラム公募地上研究, 1997年.
  7. 岸 恭一, 六反 一仁, 二川 健, 手嶋 茂忠 : 廃用性萎縮筋におけるミトコンドリア遺伝子の発現異常とその栄養学的改善法, 文部省科学研究費 基盤研究C, 1999年.
  8. 二川 健, 岸 恭一, 六反 一仁, 手嶋 茂忠, 埜中 征哉, 武田 伸一 : 無重力により発現の変動する新規筋肉内遺伝子の解析, 日本宇宙フォーラム公募地上研究, 2000年.
  9. 二川 健, 岸 恭一, 六反 一仁, 柴原 進 : N末端法則を用いたジペプチドによる筋内ユビキチン蛋白質分解系の制御とその臨床応用, 文部科学省科学研究費 基盤研究C, 2001年.
  10. 岸 恭一, 二川 健, 六反 一仁 : 無重力により変動する筋肉内遺伝子群をターゲットとした新しい筋肉保護食品(剤)の開発, 文部科学省科学研究費 基盤研修C, 2001年.
Report:
  1. 二川 健, 山本 孝, 山内 有信, 大野 誉子, 難波 佳世, 木戸 康博, 岸 恭一, 六反 一仁 : 運動に伴うフリーラジカル傷害の抑制に対する大豆たん白質の効果, 大豆たん白質研究会会誌, Vol.15, 45-50頁, 大阪, 1994年12月.
  2. 平川 哲也, 山田 昌彦, 手嶋 茂忠, 坂井 敦子, 山本 孝, 二川 健, 木戸 康博, 岸 恭一, 六反 一仁 : 胃粘膜細胞のストレス反応の分子機構:グルタチオンによるストレス蛋白質遺伝子の転写調節について, Ther Res, Vol.16, No.S1, 173-177頁, 1995年5月.
  3. 平川 哲也, 六反 一仁, 手嶋 茂忠, 二川 健, 木戸 康博, 岸 恭一 : ストレスたん白質の誘導におよぼす大豆たん白質の影響, 大豆たん白質研究会会誌, Vol.16, 4-8頁, 大阪, 1995年12月.
  4. 二川 健, 手嶋 茂忠, 坂井 敦子, 木戸 康博, 岸 恭一, 六反 一仁, David H. Alpers : レチノイン酸による小腸上皮細胞株の分化誘導, Ther Res 1996, Vol.17, No.S1, S125-S129頁, 1996年5月.
  5. 木戸 康博, 岡田 邦彦, 小田原 賢二, 二川 健, 六反 一仁, 岸 恭一 : ラット腸粘膜IgA量に及ぼすタンパク質欠乏とコレラ毒素の影響, 必須アミノ酸研究, Vol.146, 40-46頁, 1996年11月.
  6. 手嶋 茂忠, 六反 一仁, 三好 真美, 平川 哲也, 二川 健, 岸 恭一 : レドックス感受性転写因子NF-κBによる胃粘膜上皮細胞の酸化ストレス応答, Ther Res, Vol.18, No.S1, 185-189頁, 1997年5月.
  7. 手嶋 茂忠, 六反 一仁, 二川 健, 岸 恭一 : マクロファージコロニー刺激因子によるIgE依存症ヒスタミン放出因子の誘導, Ther Res, Vol.19, No.S1, S166-S169頁, 1998年5月.
  8. 新田 早美, 米原 小枝, 六反 一仁, 二川 健, 岸 恭一 : 高脂肪食投与ラットの体脂肪蓄積に及ぼす大豆タンパク質と運動の効果, 必須アミノ酸研究, Vol.152, 71-76頁, 1998年10月.
  9. 河合 智子, 六反 一仁, 二川 健, 岸 恭一 : 急性ストレス負荷時の胃粘膜におけるストレス蛋白質の誘導のメカニズムとその生理作用について, Cyto-protection Biol, Vol.16, 13-16頁, 1998年12月.
  10. 二川 健, 池本 円, 渡辺 千穂, 北野 貴子, 手嶋 茂忠, 六反 一仁, 岸 恭一 : 微小重力による筋萎縮とタンパク質分解酵素, 必須アミノ酸研究, Vol.155, 37-59頁, 1999年11月.
  11. 六反 一仁, 河合 智子, 森永 寛子, 佐藤 光恵, 楠本 健二, 河原 司, 近藤 和美, 二川 健, 岸 恭一 : タンパク質栄養と熱ショック応答, 必須アミノ酸研究, Vol.156, 12-19頁, 1999年12月.
  12. 岸 恭一, 六反 一仁, 二川 健, 手嶋 茂忠 : タンパク質必要量算定の現状と問題点, 必須アミノ酸研究, Vol.156, 1-8頁, 1999年12月.
  13. 森永 寛子, 手嶋 茂忠, 佐藤 光恵, 近藤 和美, 二川 健, 岸 恭一, 六反 一仁 : 新規アレルギー関連サイトカイン(IgE依存症ヒスタミン放出因子)産出に及ぼすM-CSFの役割, Ther Res, Vol.21, No.S1, S26-S2頁, 2000年5月.
  14. 岸 恭一, 二川 健, 池本 円, 渡辺 千穂, 北野 貴子, Keeneth M. Baldwin, 泉 龍太郎, 埜中 征哉, 手嶋 茂忠, 六反 一仁, 武田 伸一 : 無重力による筋萎縮に有効な宇宙食の開発, 宇宙環境利用に関する公募地上研究(平成10年度終了分)成果報告書, 241-258頁, 2000年7月.
  15. 二川 健, 北野 貴子, 池本 円, 手嶋 茂忠, 六反 一仁, 岸 恭一, 泉 龍太郎, Keeneth M. Baldwin, 武田 伸一 : 重力により発現の変動する新規筋肉内遺伝子の解析, 必須アミノ酸研究所, Vol.158, 61-65頁, 2000年8月.
  16. 二川 健, 池本 円, 北野 貴子, 加納 美保子, 香川 和代, 武田 伸一, 埜中 征哉, 泉 龍太郎, Keeneth M. Baldwin, 手嶋 茂忠, 六反 一仁, 岸 恭一 : 微少重力環境下の骨格筋における蛋白質分解とプロテアーゼの発現, Space Utilization Research, Vol.17, 7-9頁, 2001年5月.
  17. Takeshi Nikawa, Madoka Ikemoto, Chiho Watanabe, Takako Kitano, Keeneth M. Baldwin, Ryutaro Izumi, Ikuya Nonaka, Shigetada Teshima, Kazuhito Rokutan, Shinichi Takeda and Kyoichi Kishi : Development of effective space food against weightlessness-induced muscle atrophy, The Progress Report of Ground Research Announcement for Space Utilization, Dec. 2001.
  18. 二川 健, 池本 円, 平坂 勝也, 加納 美保子, 山本 多恵子, 田中 礼子, 鎌田 まり子, 六反 一仁, 岸 恭一 : 尾部懸垂による筋肉内酸化ストレスと筋蛋白質のユビキチン化に対するシステインの阻害効果, 必須アミノ酸研究, Vol.164, 56-61頁, 2002年5月.
  19. 二川 健, 平坂 勝也, 加納 美保子, 浅野間 友紀, 水澤 典子, 六反 一仁, 岸 恭一, 小川 貴之, 安井 夏生, 池本 円, 武田 伸一, 埜中 征哉 : 宇宙フライトラットの骨格筋で発現の増大する新規遺伝子Sfigのフローニング, 必須アミノ酸研究, Vol.166, 1-6頁, 2003年3月.
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