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Tokushima UniversityGraduate School of Biomedical Sciences歯学域Oral ScienceBasic DentistryDepartment of Oral Microbiology
Tokushima UniversityFaculty of DentistryCourse in DentistryBasic Oral SciencesOral Microbiology
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Research

Field of Study

Bacteriology, Oral Microbiology

Subject of Study

細菌性肺炎の病態形成機構に基づく新規感染制御法の確立, 上気道定着細菌の全身伝播機構の解明 (レンサ球菌, インフルエンザウイルス, 細菌性肺炎)

Book / Paper

Book:

1. Tomoko Sumitomo and 川端 重忠 :
真菌,口腔微生物学・免疫学 第5版 川端重忠, 小松澤均, 大原直也, 寺尾豊 編,
医歯薬出版株式会社, Dec. 2021.
2. Tomoko Sumitomo and 川端 重忠 :
感染,イラストでわかる歯科医学の基礎 第4版 村上秀明, 西村康, 天野修 監修,
永末書店, Jun. 2021.
3. 寺尾 豊, Tomoko Sumitomo, 中田 匡宣, 磯田 竜太朗 and 川端 重忠 :
病原性レンサ球菌の病原因子の機能解析,生命歯科医学のカッティング・エッジ. 米田俊之 編,
大阪大学出版会, Mar. 2008.

Academic Paper (Judged Full Paper):

1. Takahara Yuki, Tomoko Sumitomo, Kono Masamitsu, Takemura Moe, Akamatsu Yukako, Hirose Yujiro, Yamaguchi Masaya, Nakata Masanobu, Hotomi Muneki and Kawabata Shigetada :
Pneumolysin contributes to dysfunction of nasal epithelial barrier for promotion of pneumococcal dissemination into brain tissue,
mSphere, Vol.inpress, 2024.
2. Dalia Talat, Tomoko Sumitomo, Mariko Honda-Ogawa, Yuki Takahara, Yasushi Mori, Masaya Yamaguchi, Masanobu Nakata, Madiha S Ibrahim and Shigetada Kawabata :
Two-component regulatory system TCS08 of a serotype 4 strain in pneumococcal pneumonia pathogenesis,
Journal of Oral Biosciences, Vol.66, No.3, 567-574, 2024.
(DOI: 10.1016/j.job.2024.06.001,   PubMed: 38885903,   Elsevier: Scopus)
3. Katsuki Takebe, Mamoru Suzuki, Takeshi Sangawa, Bernd Kreikemeyer, Masaya Yamaguchi, Narikazu Uzawa, Tomoko Sumitomo, Shigetada Kawabata and Masanobu Nakata :
Analysis of FctB3 crystal structure and insight into its structural stabilization and pilin linkage mechanisms,
Archives of Microbiology, Vol.206, No.1, 4, 2023.
(DOI: 10.1007/s00203-023-03727-1,   PubMed: 37994962)
4. Seiko Kubota, Masanobu Nakata, Yujiro Hirose, Masaya Yamaguchi, Bernd Kreikemeyer, Narikazu Uzawa, Tomoko Sumitomo and Shigetada Kawabata :
Involvement of ribonuclease Y in pilus production by M49 Streptococcus pyogenes strain via modulation of messenger RNA level of transcriptional regulator,
Microbiology and Immunology, Vol.67, No.7, 319-333, 2023.
(DOI: 10.1111/1348-0421.13069,   PubMed: 37138376,   Elsevier: Scopus)
5. Yukako Akamatsu, Takami Akagi, Tomoko Sumitomo, Yuki Takahara, Shigehisa Akiyama, Shigetada Kawabata and Mitsuru Akashi :
Construction of human three-dimensional lung model using layer-by-layer method.,
Tissue Engineering. Part C, Methods, Vol.29, No.3, 95-102, 2023.
(DOI: 10.1089/ten.TEC.2022.0184,   PubMed: 36721369)
6. Nobuo Okahashi, Tomoko Sumitomo, Masanobu Nakata, Hirotaka Kuwata and Shigetada Kawabata :
Oral mitis group streptococci reduce infectivity of influenza A virus via acidification and H2O2 production.,
PLoS ONE, Vol.17, No.11, e0276293, 2022.
(DOI: 10.1371/journal.pone.0276293,   PubMed: 36350830)
7. Bergmann René, Gulotta Giuseppe, Andreoni Federica, Tomoko Sumitomo, Kawabata Shigetada, Zinkernagel S. Annelies, Chhatwal S. Gursharan, Nizet Victor, Rohde Manfred and Uchiyama Satoshi :
The Group A Streptococcus Interleukin-8 Protease SpyCEP Promotes Bacterial Intracellular Survival by Evasion of Autophagy,
Infectious Microbes and Diseases, Vol.4, No.3, 116-123, 2022.
(DOI: 10.1097/IM9.0000000000000098,   Elsevier: Scopus)
8. Moe Takemura, Masaya Yamaguchi, Momoko Kobayashi, Tomoko Sumitomo, Yujiro Hirose, Daisuke Okuzaki, Masayuki Ono, Daisuke Motooka, Kana Goto, Masanobu Nakata, Narikazu Uzawa and Shigetada Kawabata :
Pneumococcal BgaA Promotes Host Organ Bleeding and Coagulation in a Mouse Sepsis Model.,
Frontiers in Cellular and Infection Microbiology, Vol.12, 2022.
(DOI: 10.3389/fcimb.2022.844000,   PubMed: 35846740)
9. Nobuo Okahashi, Tomoko Sumitomo, Masanobu Nakata and Shigetada Kawabata :
Secondary streptococcal infection following influenza.,
Microbiology and Immunology, Vol.66, No.6, 253-263, 2022.
(DOI: 10.1111/1348-0421.12965,   PubMed: 35088451)
10. Tomoko Sumitomo, Masanobu Nakata, Satoshi Nagase, Yuki Takahara, Mariko Honda-Ogawa, Yasushi Mori, Yukako Akamatsu, Masaya Yamaguchi, Shigefumi Okamoto and Shigetada Kawabata :
GP96 Drives Exacerbation of Secondary Bacterial Pneumonia following Influenza A Virus Infection.,
mBio, Vol.12, No.3, 2021.
(DOI: 10.1128/mBio.03269-20,   PubMed: 34061598)
11. Yujiro Hirose, Masaya Yamaguchi, Tomoko Sumitomo, Masanobu Nakata, Tomoki Hanada, Daisuke Okuzaki, Daisuke Motooka, Yasushi Mori, Hiroshi Kawasaki, Alison Coady, Satoshi Uchiyama, Masanobu Hiraoka, H Raymond Zurich, Masayuki Amagai, Victor Nizet and Shigetada Kawabata :
Streptococcus pyogenes upregulates arginine catabolism to exert its pathogenesis on the skin surface.,
Cell Reports, Vol.34, No.13, 2021.
(DOI: 10.1016/j.celrep.2021.108924,   PubMed: 33789094)
12. Hirose Yujiro, Yamaguchi Masaya, Takemoto Norihiko, Miyoshi-Akiyama Tohru, Tomoko Sumitomo, Nakata Masanobu, Ikebe Tadayoshi, Hanada Tomoki, Yamaguchi Takahiro, Kawahara Ryuji, Okuno Rumi, Otsuka Hitoshi, Matsumoto Yuko, Terashima Yuji, Kazawa Yu, Nakanishi Noriko, Uchida Kaoru, Akiyama Yumi, Iwabuchi Kaori, Nakagawa Chikara, Yamamoto Kazunari, Nizet Victor and Kawabata Shigetada :
Genetic Characterization of Streptococcus pyogenes emm89 Strains Isolated in Japan From 2011 to 2019,
Infectious Microbes and Diseases, Vol.2, No.4, 160-166, 2020.
(DOI: 10.1097/im9.0000000000000038,   CiNii: 1360572092721321088)
13. Masaya Yamaguchi, Moe Takemura, Kotaro Higashi, Kana Goto, Yujiro Hirose, Tomoko Sumitomo, Masanobu Nakata, Narikazu Uzawa and Shigetada Kawabata :
Role of BgaA as a Pneumococcal Virulence Factor Elucidated by Molecular Evolutionary Analysis.,
Frontiers in Microbiology, Vol.11, 2020.
(DOI: 10.3389/fmicb.2020.582437,   PubMed: 33072054)
14. Masanobu Nakata, Tomoko Sumitomo, Nadja Patenge, Bernd Kreikemeyer and Shigetada Kawabata :
Thermosensitive pilus production by FCT type 3 Streptococcus pyogenes controlled by Nra regulator translational efficiency.,
Molecular Microbiology, Vol.113, No.1, 173-189, 2019.
(DOI: 10.1111/mmi.14408,   PubMed: 31633834)
15. Yujiro Hirose, Masaya Yamaguchi, Daisuke Okuzaki, Daisuke Motooka, Hiroshi Hamamoto, Tomoki Hanada, Tomoko Sumitomo, Masanobu Nakata and Shigetada Kawabata :
Streptococcus pyogenes Transcriptome Changes in the Inflammatory Environment of Necrotizing Fasciitis.,
Applied and Environmental Microbiology, Vol.85, No.21, 2019.
(DOI: 10.1128/AEM.01428-19,   PubMed: 31471300)
16. Masaya Yamaguchi, Yujiro Hirose, Moe Takemura, Masayuki Ono, Tomoko Sumitomo, Masanobu Nakata, Yutaka Terao and Shigetada Kawabata :
Evades Host Cell Phagocytosis and Limits Host Mortality Through Its Cell Wall Anchoring Protein PfbA.,
Frontiers in Cellular and Infection Microbiology, Vol.9, 2019.
(DOI: 10.3389/fcimb.2019.00301,   PubMed: 31482074)
17. Masaya Yamaguchi, Kana Goto, Yujiro Hirose, Yuka Yamaguchi, Tomoko Sumitomo, Masanobu Nakata, Kazuhiko Nakano and Shigetada Kawabata :
Identification of evolutionarily conserved virulence factor by selective pressure analysis of Streptococcus pneumoniae.,
Communications Biology, Vol.2, 96, 2019.
(DOI: 10.1038/s42003-019-0340-7,   PubMed: 30886906)
18. Tomoko Sumitomo, Yasushi Mori, Yuumi Nakamura, Mariko Honda-Ogawa, Seitaro Nakagawa, Masaya Yamaguchi, Hiroyuki Matsue, Yutaka Terao, Masanobu Nakata and Shigetada Kawabata :
Streptococcal Cysteine Protease-Mediated Cleavage of Desmogleins Is Involved in the Pathogenesis of Cutaneous Infection.,
Frontiers in Cellular and Infection Microbiology, Vol.8, 2018.
(DOI: 10.3389/fcimb.2018.00010,   PubMed: 29416987)
19. Yujiro Hirose, Masaya Yamaguchi, Kana Goto, Tomoko Sumitomo, Masanobu Nakata and Shigetada Kawabata :
Competence-induced protein Ccs4 facilitates pneumococcal invasion into brain tissue and virulence in meningitis.,
Virulence, Vol.9, No.1, 1576-1587, 2018.
(DOI: 10.1080/21505594.2018.1526530,   PubMed: 30251911)
20. Satoshi Nagase, Miki Matsue, Yasushi Mori, Mariko Honda-Ogawa, Kayo Sugitani, Tomoko Sumitomo, Masanobu Nakata, Shigetada Kawabata and Shigefumi Okamoto :
Comparison of antimicrobial spectrum and mechanisms of organic virgin coconut oil and lauric acid against bacteria,
Journal of Wellness and Health Care, Vol.41, No.1, 87-95, 2017.
(DOI: 10.24517/00048862,   CiNii: 1390572174913608192)
21. Masaya Yamaguchi, Masanobu Nakata, Ryuichi Sumioka, Yujiro Hirose, Satoshi Wada, Yukihiro Akeda, Tomoko Sumitomo and Shigetada Kawabata :
Zinc metalloproteinase ZmpC suppresses experimental pneumococcal meningitis by inhibiting bacterial invasion of central nervous systems.,
Virulence, Vol.8, No.8, 1516-1524, 2017.
(DOI: 10.1080/21505594.2017.1328333,   PubMed: 28489958)
22. Ryuichi Sumioka, Masanobu Nakata, Nobuo Okahashi, Yixuan Li, Satoshi Wada, Masaya Yamaguchi, Tomoko Sumitomo, Mikako Hayashi and Shigetada Kawabata :
Streptococcus sanguinis induces neutrophil cell death by production of hydrogen peroxide.,
PLoS ONE, Vol.12, No.2, 2017.
(DOI: 10.1371/journal.pone.0172223,   PubMed: 28222125)
23. Mariko Honda-Ogawa, Tomoko Sumitomo, Yasushi Mori, Talat Dalia Hamd, Taiji Ogawa, Masaya Yamaguchi, Masanobu Nakata and Shigetada Kawabata :
Endopeptidase O Contributes to Evasion from Complement-mediated Bacteriolysis via Binding to Human Complement Factor C1q.,
The Journal of Biological Chemistry, Vol.292, No.10, 4244-4254, 2017.
(DOI: 10.1074/jbc.M116.749275,   PubMed: 28154192)
24. Yuichi Oogai, Masaya Yamaguchi, Miki Kawada-Matsuo, Tomoko Sumitomo, Shigetada Kawabata and Hitoshi Komatsuzawa :
Lysine and Threonine Biosynthesis from Aspartate Contributes to Staphylococcus aureus Growth in Calf Serum.,
Applied and Environmental Microbiology, Vol.82, No.20, 6150-6157, 2016.
(DOI: 10.1128/AEM.01399-16,   PubMed: 27520813)
25. Masaya Yamaguchi, Yujiro Hirose, Masanobu Nakata, Satoshi Uchiyama, Yuka Yamaguchi, Kana Goto, Tomoko Sumitomo, Amanda L. Lewis, Shigetada Kawabata and Victor Nizet :
Evolutionary inactivation of a sialidase in group B Streptococcus,
Scientific Reports, Vol.6, No.6, 28852, 2016.
(DOI: 10.1038/srep28852,   PubMed: 27352769)
26. Tomoko Sumitomo, Masanobu Nakata, Miharu Higashino, Masaya Yamaguchi and Shigetada Kawabata :
Group A Streptococcus exploits human plasminogen for bacterial translocation across epithelial barrier via tricellular tight junctions,
Scientific Reports, Vol.6, 20069, 2016.
(DOI: 10.1038/srep20069,   PubMed: 26822058)
27. Tomoko Sumitomo :
Group A Streptococcus translocates across an epithelial barrier via degradation of intercellular junctions,
Journal of Oral Biosciences, Vol.57, No.3, 135-138, 2015.
28. Chisato Morita, Ryuichi Sumioka, Masanobu Nakata, Nobuo Okahashi, Satoshi Wada, Takashi Yamashiro, Mikako Hayashi, Shigeyuki Hamada, Tomoko Sumitomo and Shigetada Kawabata :
Cell wall-anchored nuclease of Streptococcus sanguinis contributes to escape from neutrophil extracellular trap-mediated bacteriocidal activity.,
PLoS ONE, Vol.9, No.8, e103125, 2014.
(DOI: 10.1371/journal.pone.0103125,   PubMed: 25084357)
29. Nobuo Okahashi, Tomoko Sumitomo, Masanobu Nakata, Atsuo Sakurai, Hirotaka Kuwata and Shigetada Kawabata :
Hydrogen peroxide contributes to the epithelial cell death induced by the oral mitis group of streptococci.,
PLoS ONE, Vol.9, No.1, 2014.
(DOI: 10.1371/journal.pone.0088136,   PubMed: 24498253)
30. Nobuo Okahashi, Masanobu Nakata, Tomoko Sumitomo, Yutaka Terao and Shigetada Kawabata :
Hydrogen peroxide produced by oral Streptococci induces macrophage cell death.,
PLoS ONE, Vol.8, No.5, 2013.
(DOI: 10.1371/journal.pone.0062563,   PubMed: 23658745)
31. Mariko Honda-Ogawa, Taiji Ogawa, Yutaka Terao, Tomoko Sumitomo, Masanobu Nakata, Kazunori Ikebe, Yoshinobu Maeda and Shigetada Kawabata :
Cysteine proteinase from Streptococcus pyogenes enables evasion of innate immunity via degradation of complement factors.,
The Journal of Biological Chemistry, Vol.288, No.22, 15854-15864, 2013.
(DOI: 10.1074/jbc.M113.469106,   PubMed: 23589297)
32. Tomoko Sumitomo, Masanobu Nakata, Miharu Higashino, Yutaka Terao and Shigetada Kawabata :
Group A streptococcal cysteine protease cleaves epithelial junctions and contributes to bacterial translocation.,
The Journal of Biological Chemistry, Vol.288, No.19, 13317-13324, 2013.
(DOI: 10.1074/jbc.M113.459875,   PubMed: 23532847)
33. Richard Keiji Kimura, Masanobu Nakata, Tomoko Sumitomo, Bernd Kreikemeyer, Andreas Podbielski, Yutaka Terao and Shigetada Kawabata :
Involvement of T6 pili in biofilm formation by serotype M6 Streptococcus pyogenes.,
Journal of Bacteriology, Vol.194, No.4, 804-812, 2011.
(DOI: 10.1128/JB.06283-11,   PubMed: 22155780)
34. Tomoko Sumitomo, Masanobu Nakata, Masaya Yamaguchi, Yutaka Terao and Shigetada Kawabata :
S-carboxymethylcysteine inhibits adherence of Streptococcus pneumoniae to human alveolar epithelial cells.,
Journal of Medical Microbiology, Vol.61, No.Pt 1, 101-108, 2011.
(DOI: 10.1099/jmm.0.033688-0,   PubMed: 21890513)
35. Masanobu Nakata, Richard Keiji Kimura, Tomoko Sumitomo, Satoshi Wada, Akinari Sugauchi, Eiji Oiki, Miharu Higashino, Bernd Kreikemeyer, Andreas Podbielski, Nobuo Okahashi, Shigeyuki Hamada, Ryutaro Isoda, Yutaka Terao and Shigetada Kawabata :
Assembly mechanism of FCT region type 1 pili in serotype M6 Streptococcus pyogenes.,
The Journal of Biological Chemistry, Vol.286, No.43, 37566-37577, 2011.
(DOI: 10.1074/jbc.M111.239780,   PubMed: 21880740)
36. Nobuo Okahashi, Masanobu Nakata, Yutaka Terao, Ryutaro Isoda, Atsuo Sakurai, Tomoko Sumitomo, Masaya Yamaguchi, K Richard Kimura, Eiji Oiki, Shigetada Kawabata and Takashi Ooshima :
Pili of oral Streptococcus sanguinis bind to salivary amylase and promote the biofilm formation.,
Microbial Pathogenesis, Vol.50, No.3-4, 148-154, 2011.
(DOI: 10.1016/j.micpath.2011.01.005,   PubMed: 21238567)
37. Tomoko Sumitomo, Masanobu Nakata, Miharu Higashino, Yingji Jin, Yutaka Terao, Yukako Fujinaga and Shigetada Kawabata :
Streptolysin S contributes to group A streptococcal translocation across an epithelial barrier.,
The Journal of Biological Chemistry, Vol.286, No.4, 2750-2761, 2010.
(DOI: 10.1074/jbc.M110.171504,   PubMed: 21084306)
38. Nobuo Okahashi, Masanobu Nakata, Atsuo Sakurai, Yutaka Terao, Tomonori Hoshino, Masaya Yamaguchi, Ryutaro Isoda, Tomoko Sumitomo, Kazuhiko Nakano, Shigetada Kawabata and Takashi Ooshima :
Pili of oral Streptococcus sanguinis bind to fibronectin and contribute to cell adhesion.,
Biochemical and Biophysical Research Communications, Vol.391, No.2, 1192-1196, 2009.
(DOI: 10.1016/j.bbrc.2009.12.029,   PubMed: 20004645)
39. Akihiro Shirai, Tomoko Sumitomo, Mayuko Kurimoto, Hideaki Maseda and Hiroki Kourai :
The mode of the antifungal activity of gemini-pyridinium salt against yeast,
Biocontrol Science, Vol.14, No.1, 13-20, 2009.
(DOI: 10.4265/bio.14.13,   PubMed: 19344094)
40. Masanobu Nakata, Thomas Köller, Karin Moritz, Deborah Ribardo, Ludwig Jonas, S Kevin McIver, Tomoko Sumitomo, Yutaka Terao, Shigetada Kawabata, Andreas Podbielski and Bernd Kreikemeyer :
Mode of expression and functional characterization of FCT-3 pilus region-encoded proteins in Streptococcus pyogenes serotype M49.,
Infection and Immunity, Vol.77, No.1, 32-44, 2008.
(DOI: 10.1128/IAI.00772-08,   PubMed: 18852238)
41. Akihiro Shirai, Tomoko Sumitomo, 岡村 菜穂, 大久保 彰洋, 湯浅 明彦, Hideaki Maseda and Hiroki Kourai :
銀担持アクリル繊維を含む抗菌紙の魚病原因細菌に対する殺菌特性,
Journal of Antibacterial and Antifungal Agents, Japan, Vol.36, No.9, 579-585, 2008.
(CiNii: 1520009410063770496)
42. Tomoko Sumitomo, Akihiro Shirai, Takuya Maeda, Hideaki Nagamune and Hiroki Kourai :
Construction of a leftover bath water model for microbial testing,
Biocontrol Science, Vol.11, No.3, 107-114, 2006.
(DOI: 10.4265/bio.11.107,   PubMed: 17017128)
43. Tomoko Sumitomo, Hideaki Nagamune, Takuya Maeda and Hiroki Kourai :
Correlation between the Bacterioclastic Action of a Bis-quaternary Ammonium Compound and Outer Membrane Proteins,
Biocontrol Science, Vol.11, No.3, 115-124, 2006.
(DOI: 10.4265/bio.11.115,   PubMed: 17017129,   CiNii: 1390282679441112960)
44. Akihiro Shirai, Tomoko Sumitomo, Munehiro Yoshida, Tomoyo Kaimura, Hideaki Nagamune, Takuya Maeda and Hiroki Kourai :
Synthesis and biological properties of gemini quaternary ammonium compounds,5,5'-[2,2'-(α,ω-polymethylnedicarbonyldioxy)diethyl]bis(3-alkyl-4-methylthiazolium iodide) and 5,5'- [2,2'-(ρ-phenylenedicarbonyldioxy)diethyl] bis(3-alkyl-4-methylthiazolium bromide),
Chemical & Pharmaceutical Bulletin, Vol.54, No.5, 639-645, 2006.
(DOI: 10.1248/cpb.54.639,   PubMed: 16651758)
45. Tomoko Sumitomo, 幸坂 葵, 中 秀雄, Takuya Maeda and Hiroki Kourai :
繊維製品の抗真菌性試験,
Journal of Antibacterial and Antifungal Agents, Japan, Vol.34, No.3, 141-147, 2006.

Review, Commentary:

1. Tomoko Sumitomo and Shigetada Kawabata :
Respiratory tract barrier dysfunction in viral-bacterial co-infection cases,
Japanese Dental Science Review, Vol.60, 44-52, Dec. 2024.
(Tokushima University Institutional Repository: 119256,   DOI: 10.1016/j.jdsr.2023.12.006)
2. Tomoko Sumitomo and 川端 重忠 :
インフルエンザに合併する細菌性肺炎の重要性,
歯界月報, Vol.848, 1-6, 2022.
(CiNii: 1010294643572774016)
3. Tomoko Sumitomo :
化膿レンサ球菌の上皮バリア突破機構,
Nihon Saikingaku Zasshi, Vol.72, No.3, 213-218, 2017.
(DOI: 10.3412/jsb.72.213,   PubMed: 28845032)
4. Tomoko Sumitomo :
細胞間隙経路を介した化膿レンサ球菌の上皮バリア突破機構,
大阪大学歯学雑誌, Vol.60, No.1, 15-19, 2015.
5. Tomoko Sumitomo :
細胞間隙経路を介した化膿レンサ球菌の上皮バリア突破機構,
大阪大学歯学雑誌, Vol.60, No.1, 15-19, 2015.
6. Tomoko Sumitomo and 川端 重忠 :
劇症型溶血性レンサ球菌感染症の発症に寄与する細菌因子.特集「いわゆるヒト喰いバクテリアと劇症型感染症」,
Antibiotics and Chemotherapy, Vol.29, No.7, 1430-1437, 2013.
7. Tomoko Sumitomo and 川端 重忠 :
レンサ球菌の新たな理解に向けて. 特集「病原体の感染戦略における新たな知見」,
Antibiotics and Chemotherapy, Vol.23, No.11, 1741-1747, 2007.
8. Takuya Maeda, Tomoko Sumitomo and Hiroki Kourai :
食品衛生と界面活性剤4,
Journal of Antibacterial and Antifungal Agents, Japan, Vol.33, No.10, 550-560, Oct. 2005.

Proceeding of International Conference:

1. Yamaguchi Masaya, Higashi Kotaro, Takebe Katsuki, Nakata Masanobu, Tomoko Sumitomo and Kawabata Shigetada :
Structural analysis of inactive hyaluronidase of Streptococcus pyogenes,
The 16th Japan-Korea International Symposium on Microbiology, Aug. 2024.
2. Higashi Kotaro, Yamaguchi Masaya, Takebe Katsuki, Nakata Masanobu, Tomoko Sumitomo, Suzuki Mamoru, Nizet Victor and Kawabata Shigetada :
Hyaluronidase in Streptococcus pyogenes analysis based on structural biology and molecular phylogenetics,
Society for Glycobiology 2023 Annual meeting, Nov. 2023.
3. Raras Ajeng Enggardipta, Minato Akizuki, Tomoko Sumitomo, Kazumitsu Sekine, Kenichi Hamada and Hiromichi Yumoto :
Comparison of Chitosan with Different Molecular Weights as Possible Antibiofilm Materials Against Enterococcus faecalis Biofilms,
The 22nd Scientific Congress of the Asian Pacific Endodontic Confederation (APEC) 2023, Aug. 2023.
4. Tomoko Sumitomo and Hiroki Kourai :
Bacterioclastic Action of a Gemini-Quaternary Ammonium Compound,
Membrane Stress Biotechnology Symposium, Sep. 2006.

Proceeding of Domestic Conference:

1. Okamura Keekushan, Iwata Mana, Kato Kohsuke, Tomoko Sumitomo and Kawaguchi Atsushi :
Activation mechanism of commensal Streptococcus pneumoniae by macrophage differentiation upon influenza A virus infection,
第70回日本ウイルス学会学術集会, Sep. 2023.
2. 中村 勇紀, 岩田 真奈, 加藤 広介, Tomoko Sumitomo and 川口 敦史 :
上気道常在細菌を起因としたA型インフルエンザウイルス感染による二次性細菌性肺炎マウス モデルの開発,
第70回日本ウイルス学会学術集会, Sep. 2023.
3. 大野 誠之, 山口 雅也, 元岡 大祐, 広瀬 雄二郎, 東 孝太郎, 秋山 徹, Tomoko Sumitomo, 池辺 忠義, 山口 貴弘, 河原 隆二, 奥野 ルミ, 大塚 仁, 松本 裕子, 賀澤 優 and 川端 重忠 :
オミクス解析 を用いたemm89型化膿レンサ球菌侵襲性感染症の発症に関与する,
第8回口腔微生物研究会, Sep. 2023.
4. Tomoko Sumitomo and 川端 重忠 :
新規感染制御法の確立に向けた細菌性肺炎の重症化機構の解明,
第65回歯科基礎医学会学術大会, Sep. 2023.
5. 中田 匡宣, 窪田 星子, 広瀬 雄二郎, 山口 雅也, Tomoko Sumitomo and 川端 重忠 :
化膿レンサ球菌のRNase Yによる線毛産生量の調節,
第65回歯科基礎医学会学術大会, Sep. 2023.
6. 松本 愛理, 大貝 悠一, Tomoko Sumitomo and 中田 匡宣 :
ミティス群 レンサ球菌が産生する細胞外小胞の作用特性の解明,
第65回歯科基礎医学会学術大会, Sep. 2023.
7. 武部 克希, 鈴木 守, 東 孝太郎, 山口 雅也, Tomoko Sumitomo, 川端 重忠 and 中田 匡宣 :
Streptococcus sanguinis が産生する線毛タンパク質のX線結晶構造解析,
第65回歯科基礎医学会学術大会, Sep. 2023.
8. 松本 愛理, 大貝 悠一, Atsushi Tabata, Tomoko Sumitomo and 中田 匡宣 :
ミティス群レンサ球菌における細胞外小胞の産生とその作用特性,
第75回九州微生物研究フォーラム2023, Sep. 2023.
9. 大野 誠之, 山口 雅也, 元岡 大祐, 広瀬 雄二郎, 東 孝太郎, 秋山 徹, Tomoko Sumitomo, 池辺 忠義, 山口 貴弘, 河原 隆二, 奥野 ルミ, 大塚 仁, 松本 裕子, 賀澤 優, 中西 典子 and 川端 重忠 :
日本および世界のemm89型化膿レンサ球菌侵襲性感染症に関与する遺伝因子 の比較,
第53回レンサ球菌研究会, Jul. 2023.
10. 大野 誠之, 山口 雅也, 元岡 大祐, 広瀬 雄二郎, 東 孝太郎, 秋山 徹, Tomoko Sumitomo, 池辺 忠義, 奥野 ルミ and 川端 重忠 :
侵襲性に関与するemm89型化膿レンサ球菌の因子の探索と分子生物学的解析,
第96回日本細菌学会総会, Mar. 2023.
11. Tomoko Sumitomo :
インフルエンザに合併する細菌性肺炎の重症化分子機構,
第2回 日本医学会連合「Rising Star」リトリート, Mar. 2023.
12. Shoko Ueta, 栗本 麻友子, Tomoko Sumitomo, Akihiro Shirai, Hideaki Maseda and Hiroki Kourai :
酵母に対するジェミニ型第四アンモニウム塩系薬剤の殺菌機構,
第119回徳島生物学会, Dec. 2007.
13. 森下 裕生, 室巻 良彦, Tomoko Sumitomo, Akihiro Shirai, Hideaki Maseda and Hiroki Kourai :
ジェミニ型第四アンモニウム塩系薬剤の毒性と化学構造の定量的構造活性相関解析,
日本防菌防黴学会 第34回年次大会, Aug. 2007.
14. 岡村 菜穂, Tomoko Sumitomo, 大久保 彰洋, 湯浅 明彦, Akihiro Shirai, Hideaki Maseda and Hiroki Kourai :
魚病細菌に対する光触媒抗菌紙の殺菌特性,
日本防菌防黴学会 第34回年次大会, Aug. 2007.
15. Akihiro Shirai, 栗本 麻友子, Tomoko Sumitomo, Hideaki Maseda and Hiroki Kourai :
酵母に対するジェミニ型ピリジニウム塩系薬剤の殺菌機構,
日本防菌防黴学会 第34回年次大会, Aug. 2007.
16. Hideaki Maseda, 小中 瑠実, Hideaki Nagamune, Tomoko Sumitomo, Takuya Maeda and Hiroki Kourai :
Serratia marcescens の消毒剤および抗生物質に対する耐性機構の解明,
日本細菌学会, Mar. 2007.
17. 古小路 夏美, Tomoko Sumitomo, Hideaki Maseda, Takuya Maeda and Hiroki Kourai :
多剤交叉耐性Achromobacter sp.の耐性化機構の解明,
日本防菌防黴学会2006年度若手の会, Oct. 2006.
18. 北浦 真希, Tomoko Sumitomo, Takuya Maeda, Hideaki Maseda and Hiroki Kourai :
セラチアに対するジェミニ型第四アンモニウム塩系薬剤の殺菌機構の解明,
日本防菌防黴学会2006年度若手の会, Oct. 2006.
19. Shoko Ueta, Mayuko Kurimoto, Tomoko Sumitomo, Takuya Maeda, Hideaki Maseda and Hiroki Kourai :
酵母に対するジェミニ型第四アンモニウム塩系薬剤の殺菌機構,
日本防菌防黴学会2006年度若手の会, Oct. 2006.
20. 岡村 菜穂, Tomoko Sumitomo, Takuya Maeda, Hideaki Maseda and Hiroki Kourai :
gemini型第四アンモニウム塩の枯草菌(Bacillus subtilis)に対する殺菌機構の解明,
日本防菌防黴学会2006年度若手の会, Oct. 2006.
21. 渡辺 裕子, Tomoko Sumitomo, Takuya Maeda, Hideaki Nagamune and Hiroki Kourai :
セラチアの殺菌消毒剤耐性化機構,
日本防菌防黴学会, Nov. 2005.
22. 数藤 萌, 岡本 好子, Tomoko Sumitomo, Takuya Maeda and Hiroki Kourai :
MRSAに対するGemini型第四アンモニウム塩の殺菌機構,
日本防菌防黴学会, Nov. 2005.
23. 福居 麻弓, 射本 康夫, 才所 未来, 辻 陽平, 山本 ゆかり, Tomoko Sumitomo, Takuya Maeda and Hiroki Kourai :
Gemini型第四アンモニウム塩の抗菌特性,
日本防菌防黴学会, Nov. 2005.
24. Tomoko Sumitomo, Akihiro Shirai, Hideaki Nagamune, Takuya Maeda and Hiroki Kourai :
ビス型第四アンモニウム塩系薬剤の殺菌メカニズムの解明,
日本防菌防黴学会 第32回年次大会, May 2005.
25. Tomoko Sumitomo, Akihiro Shirai, 藪原 忠男, 吉成 安純, 唐木 真理, 渡辺 裕子, 浅田 舞子, 栗本 麻友子, 野々宮 正晃, 浜川 智江, 林 正道, 三上 勝弘 and Hiroki Kourai :
微生物試験用モデル残り湯の構築,
日本防菌防黴学会 第32回年次大会, May 2005.
26. Tomoko Sumitomo, Akihiro Shirai, 藪原 忠男, 吉成 安純, 唐木 真理, 渡辺 裕子, 浅田 舞子, 栗本 麻友子, 野々宮 正晃, 浜川 智江, 林 正道, 三上 勝弘 and Hiroki Kourai :
風呂残り湯の微生物学的及び化学的解析,
日本防菌防黴学会 第32回年次大会, May 2005.
27. Tomoko Sumitomo, Akihiro Shirai, Takuya Maeda, Hideaki Nagamune and Hiroki Kourai :
ビス型第四アンモニウム塩系殺菌剤の殺菌メカニズムの解明,
日本防菌防黴学会 2004年度若手の会, Oct. 2004.
28. 山口 文子, Tomoko Sumitomo, Takuya Maeda, Hideaki Nagamune and Hiroki Kourai :
ビス型第四級アンモニウム塩系薬剤の殺菌メカニズム,
日本防菌防黴学会 第31回年次大会, Vol.IIDp-10, May 2004.
29. Tomoko Sumitomo, Hideaki Nagamune, Takuya Maeda and Hiroki Kourai :
ビス型第四級アンモニウム塩系薬剤の細胞破壊作用とOmpEの関連性,
日本防菌防黴学会 第31回年次大会, Vol.IIDp-8, May 2004.
30. Tomoko Sumitomo, Hiroki Kourai, 山仲 浩二, 曽田 勇作 and 青木 美保 :
空気殺菌装置の開発と殺菌評価,
日本防菌防黴学会 第30回年次大会, May 2003.

Et cetera, Workshop:

1. 大野 誠之, 山口 雅也, 元岡 大祐, 広瀬 雄二郎, 東 孝太郎, 秋山 徹, Tomoko Sumitomo, 池辺 忠義, 山口 貴弘, 河原 隆二, 奥野 ルミ, 大塚 仁, 松本 裕子, 賀澤 優, 中西 典子 and 川端 重忠 :
日本および世界のemm89型化膿レンサ球菌侵襲性感染症に関与する遺伝因子の比較,
第53回レンサ球菌研究会, Jul. 2023.

Patent:

1. Hiroki Kourai and Tomoko Sumitomo : 抗ウイルス剤, 2007-053943 (Mar. 2007), 2008-214268 (Sep. 2008), .

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • BacPROTACsを活用した歯周病原性バイオフィルム制御技術の創生 (Project/Area Number: 24K22190 )
  • 肺炎球菌の細胞壁分解能が病態形成と薬剤耐性獲得に果たす役割の解明 (Project/Area Number: 23K27764 )
  • 細菌の耐性化機構を回避するファージ療法の創出 (Project/Area Number: 22K19618 )
  • 高齢者気道組織を再現する動物モデルを用いた肺炎発症機構の解明と診断法への応用 (Project/Area Number: 23K24559 )
  • レンサ球菌のニッチ拡大機構の解明と新規感染制御法の探索 (Project/Area Number: 23K24520 )
  • Single-cell analysis of the host transcriptional response during pneumococcal infection (Project/Area Number: 20K21675 )
  • Exploration of novel regulatory mechanisms of translation in bacteria (Project/Area Number: 19K22715 )
  • Investigation of novel infection control strategy based on bacterial evolutional information (Project/Area Number: 19K22710 )
  • Molecular mechanisms underlying streptococcal infections for development of preventive and therapeutic measures (Project/Area Number: 19H03825 )
  • Exploration of a novel dissemination route for development of therapeutic strategies against bacterial meningitis (Project/Area Number: 18K19643 )
  • Exploration of pathogenicity caused by association and antigenicity of fibrous protein polymers present on the bacterial cell surface (Project/Area Number: 17K19751 )
  • Streptococcal translocation across epithelial barrier via tricellular junction (Project/Area Number: 17K11610 )
  • Analysis of interaction between streptococci and host during bacterial dissemination (Project/Area Number: 17H04369 )
  • Role of streptococcal arginie deiminase in the evasion of host immunity (Project/Area Number: 16K15787 )
  • Molecular epidemiological analysis of Streptococcus pneumoniae in Southeast Asian countries (Project/Area Number: 16H05847 )
  • Exploration of streptococcal factors related with onset of bacteremia and systemic dissemination (Project/Area Number: 15H05012 )
  • Analysis of ornithine rhamnolipid-like pigment from oral bacteria (Project/Area Number: 26670800 )
  • Analysis of streptococcal translocation across epithelial barrier via paracellular route (Project/Area Number: 26462780 )
  • Analysis of expression mechanisms and adhesive functions of streptococal pili (Project/Area Number: 26462779 )
  • Group A Streptococcus translocates across an epithelial barrier (Project/Area Number: 24791961 )
  • Dvelopment of novel adjuvant which constructed by DNA origami technology (Project/Area Number: 24659836 )
  • Role of cyclodextrin in oral bacteria-associated systemic illness (Project/Area Number: 24659812 )
  • Exploration of bacterial factors that inactivate complement regulatory factors and induce invasive infectious diseases (Project/Area Number: 24390410 )
  • Analysis of virulence regulatory mechanism of group A streptococcal ncRNA (Project/Area Number: 23592700 )
  • Group A streptococci translocates across epithelial barrier via intercellular junction cleavage (Project/Area Number: 20791336 )
  • Functional analysis of adhesins and colonization factors produced by human pathogenic streptococci (Project/Area Number: 20390465 )
  • Protective immunity against group Astreptococcus infection following immunization with fibronectin-binding proteins (Project/Area Number: 18390489 )
  • Search by Researcher Number (50423421)